Traditional Chinese medicine tea substitute drink and application thereof

Abstract

The invention provides a traditional Chinese medicine tea substitute drink and application thereof.The traditional Chinese medicine tea substitute drink is prepared from 14-20 parts of milkvetch roots, 10-13 parts of honeysuckle flowers, 8-10 parts of mulberry leaves, 10-13 parts of reed rhizomes, 4-6 parts of mint and 2-4 parts of honey-fried licorice roots, and the milkvetch roots are pretreated through the following method that 1-3 times of 30%-70% ethanol solution is added into the milkvetch roots to be heated and refluxed for 1-3 h; and drying the filter residue and the extracting solution under reduced pressure, and crushing to obtain the traditional Chinese medicine composition. Components used by the traditional Chinese medicine tea substitute are all medicinal and edible traditional Chinese medicines, radix astragali and other medicines are reasonably matched to avoid excessive tonifying and excessive internal heat of a single formula, and the traditional Chinese medicine tea substitute can be taken after being mixed with water for a long time; astragalus membranaceus is dried after being soaked in ethanol, the utilization rate of bioactive components is high, and the qi tonifying effect is good.

Description

Technical Field

[0001] The present invention relates to the technical field of Chinese medicine preparations, and in particular to a Chinese medicine tea substitute and application thereof. Background Art

[0002] With the development of society, people's living standards are constantly improving; at the same time, due to factors such as fierce social competition, high pressure, and improper diet, the number of people in sub-health status has increased sharply, with poor resistance and prone to qi deficiency syndrome.

[0003] Qi deficiency syndrome is a common basic symptom in clinical practice. It refers to the deficiency of vital energy. The functions of Qi such as promotion, warming, consolidation, defense, and qi transformation as well as the functions of internal organs and tissues are all declined. The main symptoms include fatigue, shortness of breath, laziness to speak, poor appetite, loose stools, spontaneous sweating, and weak pulse. It may be caused by malnutrition, excessive work and consumption.

[0004] Chinese herbal tea substitutes, also known as tea preparations, refer to the combination of tea and Chinese herbal medicine, or the processing of Chinese herbal medicine (single or compound) into coarse or fine powder as needed, and the drinking of the mixture by decocting it with water or brewing it with boiling water. It has the characteristics of small side effects, safety and reliability, simple and economical methods, and sustained and stable therapeutic effects, and plays an irreplaceable role in "preventive treatment".

[0005] At present, the types of tea substitutes on the market are mostly health care products, which can no longer meet the needs of modern society. In view of this, the present invention is proposed. Summary of the invention

[0006] The problem solved by the invention is how to treat people with qi deficiency who have poor resistance and are susceptible to influenza.

[0007] In order to solve the above problems, the present invention provides a Chinese medicine tea substitute, which consists of 14-20 parts of astragalus, 10-13 parts of honeysuckle, 8-10 parts of mulberry leaves, 10-13 parts of reed roots, 4-6 parts of mint, and 2-4 parts of licorice; wherein the astragalus is pretreated by the following method: 1-3 times of 30%-70% ethanol solution is added to the astragalus, heated under reflux for 1-3h, and the filtrate and extract are dried under reduced pressure and then crushed to obtain the tea.

[0008] The sources, medicinal properties and effects of each raw material drug of the present invention are as follows:

[0009] Astragalus: The dried root of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge. of the Leguminosae family is sweet and slightly warm in nature, and enters the lung and spleen meridians. It has the effects of tonifying Qi and raising Yang, consolidating the exterior and stopping sweating, promoting diuresis and reducing swelling, promoting body fluid and nourishing blood, relieving stagnation and relieving numbness, expelling toxins and discharging pus, and astringing sores and promoting tissue regeneration.

[0010] Honeysuckle: The dried buds or just-opened flowers of Lonicera japonica Thunb., Lonicerahypoglauca Miq., Lonicera confusa DC. or Lonicera adasystyla Rehd. of the Caprifoliaceae family. It is cold in nature, sweet in taste, and enters the lung, heart, and stomach meridians. It has the effects of clearing away heat and detoxifying, anti-inflammatory, and tonifying deficiency and treating wind.

[0011] Mulberry leaves: The dried leaves of Morus alba L., a plant of the Moraceae family, are cold in nature, sweet and bitter in taste, and have the effects of dispersing wind-heat, clearing the lungs and moistening dryness, clearing the liver and improving eyesight.

[0012] Reed root: The dried rhizome of Phragmites communis Trin., a grass plant, has sweet and cold properties. It enters the lung and stomach meridians. It has the effects of clearing away heat and purging fire, promoting the production of body fluids and quenching thirst, relieving restlessness, stopping vomiting, and promoting urination.

[0013] Mint: The dried aerial part of the mint Mentha haplocalyx Briq. of the Lamiaceae family. It is cool in nature and has the effects of dispersing wind-heat, clearing the head, moistening the throat, clearing rashes, calming the liver and promoting qi.

[0014] Licorice: The root and rhizome of Glycyrrhiza uralensis Fisch., a plant of the Leguminosae family and the genus Glycyrrhiza. It is sweet and flat in nature, and enters the heart, lung, spleen, and stomach meridians. It has the effects of tonifying the spleen and replenishing qi, clearing away heat and detoxifying, removing phlegm and relieving cough, relieving acute pain, and harmonizing various medicines.

[0015] The Chinese herbal tea substitute of the present invention uses astragalus to replenish qi to "strengthen the body", and uses honeysuckle, mulberry leaves, reed roots and mint to assist the main medicine in the formula to play a strengthening effect. It "strengthens the body" on the basis of "eliminating evil", and "strengthens the body" and "eliminating evil" are carried out simultaneously to improve human immunity, which is in line with the compatibility principle of traditional Chinese medicine for preventing and treating diseases.

[0016] Preferably, it is composed of 15 parts of astragalus, 12 parts of honeysuckle, 9 parts of mulberry leaves, 12 parts of reed roots, 5 parts of mint, and 3 parts of roasted licorice.

[0017] Preferably, the Chinese medicine tea substitute is prepared by the following method: crush the astragalus and heat it with 1-3 times v / ml 30-70% ethanol solution for 1-3h, collect the extract and repeat the operation once, combine the extract and reduce the pressure and dry it together with the filter residue, then crush it, crush other Chinese medicines that are both medicine and food and mix them with the astragalus residue, and then pack the obtained crushed material into tea bags (10g / bag), and take it after brewing or decocting. Preferably, the concentration of the ethanol solution is 60%.

[0018] The use of the above-mentioned Chinese medicinal tea substitute in the preparation of a health product for preventing and treating qi deficiency. Preferably, the qi deficiency is caused by excessive fatigue and / or improper diet.

[0019] Compared with the prior art, the technical effects of the present invention are: 1) the components used are all Chinese medicines of the same origin as food and medicine, and the rational combination of astragalus and other medicines can avoid excessive tonic and internal heat from a single prescription, and the medicine can be taken with water for a long time; 2) the astragalus is soaked in ethanol and then dried, so the utilization rate of the bioactive ingredients is high and the qi-tonifying effect is good; 3) when honeysuckle, reed root and astragalus are used together, they have a better qi-tonifying effect than using each of them alone, and there is a synergistic effect between the two to further improve the effect of preventing and treating qi deficiency. DETAILED DESCRIPTION

[0020] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and understandable, the specific embodiments of the present invention are described in detail below. In the absence of conflict, the technical features of the present invention can be combined with each other.

[0021] Qi is the most basic substance that makes up the human body. It is distributed in all the internal organs, meridians and other tissues and organs throughout the body. It is everywhere and plays multiple roles such as promotion, gasification and nutrition at all times, thereby generating and maintaining various life activities. However, with the development of society, the pace of life is accelerating, and a large number of people are in sub-health status and are prone to Qi deficiency due to excessive fatigue and irregular work and rest.

[0022] Chinese herbal tea substitutes are referred to as "medicinal tea". They are a traditional dosage form in my country. They are prepared by mixing single or compound Chinese herbal medicines with tea leaves (or without tea leaves), decocting or brewing them, and then drinking them. Since the Spring and Autumn Period and the Warring States Period, Chinese herbal tea substitutes have a history of nearly thousands of years and have become a major feature of medical prevention and treatment of diseases and health care. However, there is currently no targeted tea substitute to meet the needs of preventing and treating qi deficiency syndrome.

[0023] Example 1

[0024] A Chinese medicine tea substitute, the dosage of each component is as follows: 15g of astragalus, 12g of honeysuckle, 9g of mulberry leaf, 12g of reed root, 5g of mint, 3g of licorice root. The preparation method is as follows: the above Chinese medicines with medicinal and edible properties are crushed separately and mixed, and then the crushed materials are packaged into tea bags (10g / bag), and then taken after brewing or decocting.

[0025] Example 2

[0026] A Chinese medicine tea substitute, the dosage of each component is as follows: 15g of astragalus, 12g of honeysuckle, 9g of mulberry leaf, 12g of reed root, 5g of mint, and 3g of licorice root. The preparation method is as follows: after crushing the astragalus, heat it to 55°C with 1.5 times v / ml of 100% ethanol solution and reflux it for 1 hour, separate the extract and repeat the operation once, crush the drug residue after vacuum drying, crush other Chinese medicines with medicinal and edible properties and mix them with the astragalus drug residue, and then pack the obtained crushed material into tea bags (10g / bag), and take it after brewing or decocting.

[0027] Example 3

[0028] A Chinese medicine tea substitute, the dosage of each component is as follows: 15g of Astragalus, 12g of Honeysuckle, 9g of Mulberry Leaf, 12g of Phragmites, 5g of Mint, and 3g of Radix Glycyrrhizae Preparata. The preparation method is as follows: after crushing the Astragalus, heat it to 55°C with 1.5 times v / ml of 100% ethanol solution and reflux it for 1 hour, collect the extract and repeat the operation once, combine the extracts, dry them under reduced pressure and then crush them, crush other Chinese medicines that are both medicine and food and mix them with the Astragalus residue, and then pack the obtained crushed material into tea bags (10g / bag), and take it after brewing or decocting.

[0029] Example 4

[0030] A Chinese herbal tea substitute, comprising the following components in the following amounts: 15 g of astragalus, 12 g of honeysuckle, 9 g of mulberry leaf, 12 g of reed root, 5 g of mint and 3 g of licorice root, and prepared by the following method: crushing the astragalus, heating it to 55°C with 1.5 times v / m1 of 100% ethanol solution and reflux it for 1 hour, collecting the extract and repeating the operation once, combining the extract and drying it together with the filter residue under reduced pressure and then crushing it, crushing other Chinese herbal medicines that are both medicine and food and mixing them evenly with the astragalus residue, and then packaging the crushed material into tea bags (10 g / bag), which can be taken after brewing or decocting.

[0031] Example 5

[0032] A Chinese herbal tea substitute, comprising the following components in the following amounts: 15 g of astragalus, 12 g of honeysuckle, 9 g of mulberry leaf, 12 g of reed root, 5 g of mint and 3 g of licorice root, and prepared by the following method: crushing the astragalus, heating it to 55°C with 1.5 times v / m1 of 80% ethanol solution and reflux it for 1 hour, collecting the extract and repeating the operation once, combining the extract and drying it together with the filter residue under reduced pressure and then crushing it, crushing other Chinese herbal medicines that are both medicine and food and mixing them evenly with the astragalus residue, and then packaging the crushed material into tea bags (10 g / bag), which can be taken after brewing or decocting.

[0033] Example 6

[0034] A Chinese herbal tea substitute, comprising the following components in the following amounts: 15 g of astragalus, 12 g of honeysuckle, 9 g of mulberry leaf, 12 g of reed root, 5 g of mint and 3 g of licorice root, and prepared by the following method: crushing the astragalus, heating it to 55°C with 1.5 times v / m1 of 60% ethanol solution and reflux it for 1 hour, collecting the extract and repeating the operation once, combining the extract and drying it together with the filter residue under reduced pressure and then crushing it, crushing other Chinese herbal medicines that are both medicine and food and mixing them evenly with the astragalus residue, and then packaging the crushed material into tea bags (10 g / bag), which can be taken after brewing or decocting.

[0035] Comparative Example 1

[0036] A Chinese herbal tea substitute, comprising the following components in the following amounts: 15 g of astragalus, 24 g of honeysuckle, 9 g of mulberry leaf, 5 g of mint and 3 g of licorice root, and prepared by the following method: crushing the astragalus, heating it to 55°C with 1.5 times v / m1 of 60% ethanol solution and reflux it for 1 hour, collecting the extract and repeating the operation once, combining the extract and drying it together with the filter residue under reduced pressure and then crushing it, crushing other Chinese herbal medicines that are both medicine and food and mixing them evenly with the astragalus residue, and then packaging the crushed material into tea bags (10 g / bag), which can be taken after brewing or decocting.

[0037] Comparative Example 2

[0038] A Chinese herbal tea substitute, comprising the following components in the following amounts: 15 g of astragalus, 9 g of mulberry leaf, 24 g of reed root, 5 g of mint and 3 g of licorice root, and prepared by the following method: crushing the astragalus, heating it to 55°C with 1.5 times v / m1 of 60% ethanol solution and reflux it for 1 hour, collecting the extract and repeating the operation once, combining the extract and drying it together with the filter residue under reduced pressure and then crushing it, crushing other Chinese herbal medicines that are both medicine and food and mixing them evenly with the astragalus residue, and then packaging the obtained crushed material into tea bags (10 g / bag), which can be taken after brewing or decocting.

[0039] Comparative Example 3

[0040] A Chinese herbal tea substitute, comprising the following components in the following amounts: 15 g of astragalus, 12 g of honeysuckle, 9 g of mulberry leaf, 12 g of reed root, 5 g of mint and 3 g of licorice root, and prepared by the following method: crushing the astragalus, heating it to 55°C with 1.5 times v / m1 of 40% ethanol solution and reflux it for 1 hour, collecting the extract and repeating the operation once, combining the extract and drying it together with the filter residue under reduced pressure and then crushing it, crushing other Chinese herbal medicines that are both medicine and food and mixing them evenly with the astragalus residue, and then packaging the crushed material into tea bags (10 g / bag), which can be taken after brewing or decocting.

[0041] Comparative Example 4

[0042] Take 10g of Astragalus respectively, grind them and pack them into tea bags (10g / bag).

[0043] Experimental example

[0044] 1.1 Experimental reagents:

[0045] Medication for modeling: Senna leaf water dilution. Put tap water into a beaker, place it on an electric stove and boil it. Quickly soak senna leaves in the boiling water at a ratio of 10g senna leaves to 50mL water. After cooling, filter out the senna leaves and store the remaining liquid at 4℃ for later use.

[0046] Experimental drugs: 10 g of tea bags prepared in Examples 1-6 and Comparative Examples 1-4 were placed in a round-bottom flask, 5 times the amount of double distilled water was added, and the mixture was heated to 90°C and extracted for 15 min. Then, 3 times the amount of double distilled water was added to the residue and heated to 90°C and extracted for 10 min. The extracts were combined and concentrated to 20 ml under reduced pressure on a rotary evaporator for later use.

[0047] 1.2 Grouping and modeling

[0048] 1.2.1 Animal grouping

[0049] One hundred and seventeen female Wistar rats were randomly divided into 11 groups according to their body weight. Group A was the blank control group, group B was the model control group, and groups C1-C10 were the treatment groups.

[0050] 1.2.2 Modeling method

[0051] Qi deficiency syndrome is a common basic syndrome in TCM clinical practice. There are currently a variety of methods for establishing animal models of Qi deficiency. This experiment uses senna leaf gavage + swimming to simulate the Qi deficiency syndrome caused by overwork. The specific experimental methods are as follows:

[0052] The experimental animals were placed in an animal laboratory at room temperature (20+2°C), 4-5 animals per cage, free to eat and drink, and adapted to the experimental environment for 1-3 days. Modeling began on the 4th day. The rats in groups B and C were gavaged with 3 mL of senna leaf water extract every day and swam for 15 minutes. The water depth was about 75 cm and the water temperature was 21±1°C. Each group had 9 rats. On the 7th day of the experiment, the rats in groups C1-C10 were gavaged with 3 ml of the extract concentrate of Examples 1-7 and Comparative Examples 1-4 every day, and the rats in the normal group were gavaged with 3 ml of pure water every day. While gavage, the same modeling factors were continued every day until the end of the experiment on the 25th day.

[0053] 1.2.3 Statistical methods

[0054] All data were calculated using SPSS 16.0 software, and the measurement data were expressed as mean ± standard deviation. p ≤ 0.05 indicated statistical significance.

[0055] 1.3 Experimental tests and results

[0056] 1.3.1 Exhaustive swimming test

[0057] On the 25th day of the experiment, the rats were weighed, and a lead wire (8% of the rats' body weight) was tied to the rats' tails. The rats were subjected to an exhaustive swimming test in water at a temperature of (30±1)°C and a depth of 30 cm. When the rats were exhausted (the tip of the rats' noses were submerged in the water for 10 seconds), they were promptly fished out and dried with a dry towel. The exhaustive swimming time was recorded. The results are shown in Table 1.

[0058] Table 1 Exhaustive swimming time data of different groups

[0059] Group Medication Exhaustive swimming time / s Group Medication Exhaustive swimming time / s A - 912±126 C5 Example 5 <![CDATA[876±163 abc ]]> B Pure water <![CDATA[683±157 c ]]> C6 Example 6 <![CDATA[889±148 abd ]]> C1 Example 1 <![CDATA[795±139 ac ]]> C7 Comparative Example 1 <![CDATA[753±161 ac ]]> C2 Example 2 <![CDATA[747±145 bc ]]> C8 Comparative Example 2 <![CDATA[761±149 ac ]]> C3 Example 3 <![CDATA[792±123 ac ]]> C9 Comparative Example 3 <![CDATA[861±169 abc <!-- 4 -->]]> C4 Example 4 <![CDATA[865±151 abc ]]> C10 Comparative Example 4 <![CDATA[722±143 ac ]]>

[0060] a- compared with group B, p < 0.05; b- compared with group C1, p < 0.05; c- compared with group A, p < 0.05; d- compared with group A, p > 0.05.

[0061] 1.3.2 Levels of inflammatory factors

[0062] IL-2 and TNF-α are both factors related to the body's immunity and inflammation. IL-2 is mainly secreted by activated T cells. As the "third" signal necessary for T cell activation, it binds to the IL-2 receptor on the cell surface in an autocrine form, playing a vital role in the activation and proliferation of T cells. TNF-α can promote T cells to produce various inflammatory factors, thereby promoting the occurrence of inflammatory responses, and can also reflect the level of intravascular inflammation.

[0063] After the exhaustive swimming time experiment, the rats were fasted for 12 hours. The next day, the rats' eyeballs were removed to collect blood, and the blood was placed in a non-anticoagulant centrifuge tube and centrifuged at 4°C and 3500r / min for 15 minutes to separate the serum. The ELISA kit was used to analyze the IL-2 and TNF-α of the serum samples of the rats in each group according to the instructions of the kit. The results are shown in Table 2.

[0064] Table 2 Comparison of inflammatory factor levels in rats of different groups

[0065]

[0066]

[0067] a- compared with group B, p < 0.05; b- compared with group C1, p < 0.05; c- compared with group A, p < 0.05; d- compared with group A, p > 0.05.

[0068] As can be seen from the above table, 1) compared with the blank control group, the exhaustive swimming time and IL-2 and TNF-α data of rats in group B as the model control group were significantly different, indicating that the successful modeling can be used to study the preventive and therapeutic effects of tea substitutes on qi deficiency syndrome, and the ratio of TNF-α and IL-2 was extremely significant, which can be used to reflect the treatment effect.

[0069] 2) Compared with group C1, the exhausted swimming time of rats in group C2, which used alcohol extract of Astragalus as the raw material of tea substitute, was comparable to that of group B-model group, while TNF-α / IL-2 was slightly lower but not significantly different; at the same time, the exhausted swimming time and TNF-α / IL-2 of rats in group C3 were comparable to those of group C1, indicating that in the traditional sense, the use of Astragalus for invigorating Qi mainly depends on water extract, which is consistent with the cognition that Astragalus is a commonly used Qi-invigorating drug; and in group C4, after alcohol extraction of Astragalus, the extract and filter residue were dried under reduced pressure and crushed to prepare a tea substitute. The exhausted swimming time and TNF-α / IL-2 of rats after oral administration were significantly different from those of group C1, indicating that after alcohol extraction, Astragalus was dried and crushed together with the residue, there was a synergistic effect between the two, and the Qi-invigorating effect was significantly improved.

[0070] 3) Compared with group C1, there were significant differences in the exhaustive swimming time and TNF-α / IL-2 of rats in groups C5 and C6; while there were no statistical differences in the exhaustive swimming time and TNF-α / IL-2 of rats in group C6 and group A. The possible reasons are: different ethanol concentrations lead to different types and contents of extracted active ingredients, which affect the final qi-replenishing effect; after 60% ethanol extraction, the alcohol-soluble components and some water-soluble components enter the extract and adhere to the surface of the particles after reduced pressure drying. After water extraction, they can smoothly enter the water and be absorbed, with a good synergistic effect.

[0071] 4) Compared with group C7, there were significant differences in the exhaustive swimming time and TNF-α / IL-2 of rats in groups C8-C9, indicating that the qi-invigorating effect of choosing either honeysuckle or reed root in Chinese herbal tea was poor, while the effect was significantly improved when the two were added in a 1:1 ratio, indicating a synergistic effect. Astragalus is a commonly used qi-invigorating drug, but the exhaustive swimming time and TNF-α / IL-2 of rats in group C10 were slightly higher than those in the model group, but the difference was not significant, indicating that for qi deficiency caused by excessive fatigue, the qi-invigorating effect of using astragalus alone is not ideal. At the same time, in the experiment, rats in group C10 often had adverse reactions such as dry and red eyes.

[0072] Although the present invention is disclosed as above, the present invention is not limited thereto. Any person skilled in the art can make various changes and modifications without departing from the spirit and scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the scope defined by the claims.

Claims

1. A Chinese medicine tea substitute, characterized in that: The invention comprises 14-20 parts of astragalus, 10-13 parts of honeysuckle, 8-10 parts of mulberry leaves, 10-13 parts of reed roots, 4-6 parts of mint and 2-4 parts of licorice. The astragalus is pretreated by the following method: 1-3 times of 30%-70% ethanol solution is added to the astragalus, heated under reflux for 1-3h, and the filtered residue and the extract are dried under reduced pressure and then crushed to obtain the obtained product.

2. The Chinese medicinal tea substitute according to claim 1-2, characterized in that: It consists of 15 parts of astragalus, 12 parts of honeysuckle, 9 parts of mulberry leaves, 12 parts of reed roots, 5 parts of mint and 3 parts of roasted liquorice.

3. Use of the Chinese herbal tea substitute according to claims 1-2 in the preparation of health products for preventing and treating qi deficiency.

4. The use according to claim 3, characterized in that: The Qi deficiency is caused by excessive fatigue.

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