Supercritical extraction system for paclitaxel

Abstract

The invention provides a paclitaxel supercritical extraction system applied to the field of extraction, in the extraction process, a rotating kettle in an extraction tank is driven by a driving mechanism to rotate, a heavy liquid releaser in the rotating kettle is driven by a reversing mechanism to rotate in the direction opposite to the rotating direction of the rotating kettle, and the flow of heavy liquid is metered by a flowmeter; the magnetic attraction force between the electromagnetic rings is adjusted, the heavy liquid releaser is driven to descend, and the staggered overlapping area of the heavy liquid releasing face and the light liquid releasing face is adjusted. The contact area of the heavy liquid releasing face and the light liquid releasing face is changed in real time along with metering data of the flow meter; therefore, the staggered overlapping area of the heavy liquid release surface and the light liquid release surface can be adjusted in real time, the rotation rate of the rotary kettle and the heavy liquid releaser can be adjusted in real time, materials are accurately put, the phenomenon that the reaction materials are insufficient or excessive is avoided, and the device has self-adaptive intelligent adjustability, has market prospects and is suitable for application and popularization.

Description

Technical Field

[0001] The present application relates to the field of extraction, and in particular to a paclitaxel supercritical extraction system. Background Art

[0002] At present, the commonly used existing technology in the industry is as follows: In 1971, American chemists Wani et al. isolated paclitaxel, a taxane diterpene compound with high anticancer activity, from the bark of Taxus brevifolia (T. brevifolia) produced in North America, and found that paclitaxel has a unique anti-tumor effect.

[0003] Extraction of paclitaxel from yew is one of its main sources. The characteristic of paclitaxel extracted from yew is that its structure is consistent with that of paclitaxel approved by the FDA for marketing.

[0004] At present, most of the methods for extracting paclitaxel from yew are to use organic solvents such as ethyl acetate, dichloromethane, acetone, chloroform, etc. to extract the yew raw materials multiple times, and then extract and separate the extracts with organic solvents after the extracts are recovered to obtain the paclitaxel-containing extract. The prominent problems of this method are: Paclitaxel in yew has low content, many structural analogs, and is a large molecule and heat-sensitive substance. Affected by environmental conditions such as temperature, organic solvents, acid, and alkali, it is easy to degrade or isomerize to other taxanes during the extraction process. These characteristics bring great difficulties to extraction and separation, especially the proportion of light liquid and heavy liquid in the extraction process. Insufficient contact between the two during the reaction will lead to waste of materials. How to explore and choose a production process that is low-cost, more environmentally friendly, and avoids long-term heating to extract paclitaxel has important practical significance. For this reason, we propose a paclitaxel supercritical extraction system to solve the above problems. Summary of the invention

[0005] The purpose of the present application is to design a paclitaxel supercritical extraction system, which can automatically adjust the contact area and stirring rate of heavy liquid and light liquid according to the input rate of materials, thereby achieving the purpose of improving extraction efficiency and saving materials. Compared with the prior art, a paclitaxel supercritical extraction system is provided, which includes an extraction tank, a condensation tower, an evaporation tower and a control cabinet. The extract of the extraction tank is evaporated, condensed and collected through the evaporation tower and the condensation tower in turn. A rotary kettle is rotatably connected in the extraction tank, and the rotary kettle is used to adjust the mixing ratio of the extracted heavy liquid and the extracted light liquid. A heavy liquid releaser and a light liquid releaser are arranged in the rotary kettle. The heavy liquid releaser and the light liquid releaser are arranged oppositely. The heavy liquid releaser and the light liquid releaser are both multi-layer annular wave cavity structures. Each annular structure of the heavy liquid releaser is provided with a heavy liquid release surface and a heavy liquid vertical surface. Each annular structure of the light liquid releaser is provided with a light liquid vertical surface and a light liquid release surface. The heavy liquid release surface and the light liquid release surface are inclined and arranged oppositely. Release holes are provided on the heavy liquid release surface and the light liquid release surface. A light liquid inlet is provided at the bottom of the extraction tank, and a light liquid pipe is connected to the output end of the light liquid inlet. The light liquid pipe extends to the bottom of the light liquid releaser and is connected thereto. A driving mechanism for driving the rotating kettle to rotate centrifugally in the extraction tank is provided at the top of the extraction tank. A heavy liquid pipe is provided at the top of the rotating kettle, and the heavy liquid pipe is connected thereto. An adjusting mechanism for adjusting the staggered overlapping spacing between the heavy liquid releaser and the light liquid releaser is also provided at the top of the rotating kettle.

[0006] During the extraction process, the rotary kettle in the extraction tank rotates under the drive of the driving mechanism, and the heavy liquid releaser in the rotary kettle rotates in the opposite direction of the rotation direction of the rotary kettle under the drive of the reversing mechanism. At this time, heavy liquid is input into the heavy liquid pipe, and the heavy liquid flow rate is measured by the flowmeter and fed back to the control cabinet. The control cabinet adjusts the magnetic attraction between the electromagnetic rings according to the design value, and then uses the magnetic attraction between the electromagnetic rings to drive the heavy liquid releaser to overcome the tensioning spring and drop to a spacing corresponding to the proportion of the heavy liquid flow rate. At this time, the relative spacing between the heavy liquid releaser and the light liquid releaser is adjusted, and the staggered overlapping area of ​​the heavy liquid release surface and the light liquid release surface is changed. Driven by the reversing mechanism, the heavy liquid output by the heavy liquid releaser uses centrifugal force to sputter out of the release hole, impacting the light liquid output by the light liquid releaser, and performing the extraction operation. At the same time, the relative rotation of the liquid releaser and the rotary kettle can realize sufficient stirring and contact between the heavy liquid and the light liquid, thereby effectively improving the extraction efficiency.

[0007] Furthermore, the driving mechanism is a stirring motor fixed on the top of the extraction tank, the driving shaft of the stirring motor extends into the extraction tank and is fixedly connected to the top of the rotating kettle, and the rotating kettle, heavy liquid pipe and light liquid pipe are all coaxially arranged with the driving shaft of the stirring motor.

[0008] Furthermore, an adjusting column is fixed on the top of the heavy liquid releaser, a limiting ring matching the adjusting column is fixed on the top of the rotating kettle, the adjusting column is slidably connected to the inner side of the limiting ring, and a reverse mechanism is fixed on the top of the rotating kettle for driving the heavy liquid releaser to rotate in the opposite direction of the rotation direction of the rotating kettle.

[0009] Furthermore, a tension spring is fixed between the limit ring and the adjusting column, an electromagnetic ring is fixed on both the limit ring and the adjusting column, a flow meter is also fixed on the heavy liquid pipe, and the flow meter and the electromagnetic ring are electrically connected to the control cabinet through wires.

[0010] Furthermore, the tensioning spring is a high-strength fatigue-resistant spring structure, and the tensioning spring has an elastic force that drives the heavy liquid releaser to move upward and away from the light liquid releaser. The two electromagnetic rings have magnetic repulsion when powered.

[0011] Furthermore, the output end of the heavy liquid pipe is also connected to a shunt pipe, and the shunt pipe is used to evenly distribute the heavy liquid output from the heavy liquid pipe to the heavy liquid releaser.

[0012] Furthermore, the reverse mechanism includes a reverse motor fixed on the top of the rotary kettle, a driving gear column is fixed to the output end of the reverse motor, and a driven gear ring meshing with the driving gear column is fixed to the top of the adjustment column.

[0013] Furthermore, a buoyancy box is fixed at the bottom of the light liquid releaser. The buoyancy box is a closed cavity structure. The light liquid pipe passes through the buoyancy box and is connected to the light liquid releaser.

[0014] Furthermore, the rotating kettle is spindle-shaped, with a rotating ring provided in the middle of the rotating kettle, centrifugal inclined surfaces provided on the upper and lower sides of the rotating ring, a slip ring corresponding to the rotating ring provided on the inner wall of the extraction tank, the slip ring is a sealed slip ring structure, and the extraction tank is divided into two upper and lower sealed spaces by the slip ring, the sealed space located in the upper part is provided with a light liquid outlet, and the sealed space located in the lower part is provided with a heavy liquid outlet, and the centrifugal inclined surfaces are respectively connected to the corresponding sealed spaces.

[0015] Furthermore, a filter screen is fixed at the bottom of the extraction tank, and the extraction tank is used to filter the heavy liquid separated by centrifugal inclined plane.

[0016] Compared with the prior art, the advantages of this application are: (1) In the extraction process of the present invention, the rotary kettle in the extraction tank rotates under the drive of the driving mechanism, and the heavy liquid releaser in the rotary kettle rotates in the opposite direction of the rotation direction of the rotary kettle under the drive of the reverse mechanism. At this time, heavy liquid is input into the heavy liquid pipe, and the heavy liquid flow rate is measured by the flowmeter and fed back to the control cabinet. The control cabinet adjusts the magnetic attraction between the electromagnetic rings according to the design value, and then uses the magnetic attraction between the electromagnetic rings to drive the heavy liquid releaser to overcome the tensioning spring and descend to a spacing corresponding to the proportion of the heavy liquid flow rate. At this time, the relative spacing between the heavy liquid releaser and the light liquid releaser is adjusted, and the staggered overlapping area of ​​the heavy liquid release surface and the light liquid release surface is changed. Under the drive of the reverse mechanism, the heavy liquid output by the heavy liquid releaser is splashed out of the release hole by centrifugal force, impacting the light liquid output by the light liquid releaser, and performing the extraction operation. At the same time, the relative rotation of the liquid releaser and the rotary kettle can realize sufficient stirring and contact between the heavy liquid and the light liquid, thereby effectively improving the extraction efficiency.

[0017] (2) Since the contact area between the heavy liquid release surface and the light liquid release surface changes in real time with the metering data of the flow meter, the staggered overlapping area of ​​the heavy liquid release surface and the light liquid release surface can be adjusted in real time, and the rotation rate of the rotary kettle and the heavy liquid releaser can be adjusted in real time, thereby achieving accurate delivery of heavy liquid and light liquid during the extraction process to avoid insufficient or excessive reaction materials. The method has adaptive intelligent adjustability, market prospects, and is suitable for promotion and application.

[0018] (3) Through the design with a float, when the light liquid transported by the light liquid pipe is transported to the light liquid releaser and released through the light liquid release surface, the excess light liquid is filled between the light liquid releaser and the rotating kettle, and then the buoyancy of the float in the light liquid can be used to drive the light liquid releaser to move upward, thereby achieving the purpose of automatically adjusting the distance between the light liquid releaser and the heavy liquid releaser according to the input amount of light liquid.

[0019] (4) The centrifugal slope is a permeable membrane structure. The light liquid and heavy liquid after the extraction reaction will be separated due to density. During the rotation of the rotary kettle, centrifugal force is generated, causing the light liquid and heavy liquid to naturally separate up and down along the centrifugal slope, and are separated into a sealed space by centrifugal force, and separated by the light liquid outlet and the heavy liquid outlet, thereby effectively improving the separation efficiency after the extraction is reversed. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 This is a schematic diagram of the front structure of this application; Figure 2 It is a side structural schematic diagram of this application; Figure 3 It is a schematic diagram of the cross-sectional structure of this application; Figure 4 for Figure 3 The enlarged structural diagram of the middle A part; Figure 5 for Figure 3 A schematic diagram of the enlarged structure of the middle B part; Figure 6 It is a schematic diagram of the structure of the rotary kettle proposed in this application; Figure 7 This is a schematic diagram of the rotary kettle explosion structure proposed in this application; Figure 8 It is a schematic diagram of the structure of the heavy liquid releaser and the light liquid releaser proposed in this application; Fig. 9 Schematic diagram of the light liquid and heavy liquid paths during the work of this application.

[0021] Explanation of the numbers in the figure: extraction tank 1, filter screen plate 11, light liquid pipe 12, condensation tower 2, control cabinet 3, evaporation tower 4, stirring motor 5, rotary kettle 6, rotating ring 61, centrifugal inclined surface 611, limit ring 62, electromagnetic ring 621, heavy liquid releaser 7, adjusting column 701, driven gear ring 71, tensioning spring 72, driving gear column 73, heavy liquid release surface 74, heavy liquid vertical surface 75, heavy liquid pipe 8, flow meter 81, diverter pipe 82, light liquid releaser 9, float box 901, light liquid vertical surface 91, light liquid release surface 92. DETAILED DESCRIPTION

[0022] The embodiments will be combined with the drawings in the specification to clearly and completely describe the technical solution of the present application. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without making any creative work shall fall within the scope of protection of the present application.

[0023] The first implementation method:

[0024] The present invention provides a paclitaxel supercritical extraction system, please refer to Figure 1-9 , comprising an extraction tank 1, a condensation tower 2, an evaporation tower 4 and a control cabinet 3, the extract of the extraction tank 1 is evaporated, condensed and collected through the evaporation tower 4 and the condensation tower 2 in turn, the extraction tank 1 is provided with a rotary kettle 6 which is rotatably connected, the rotary kettle 6 is used to adjust the mixing ratio of the extracted heavy liquid and the extracted light liquid, the rotary kettle 6 is provided with a heavy liquid releaser 7 and a light liquid releaser 9, the heavy liquid releaser 7 and the light liquid releaser 9 are arranged opposite to each other, the heavy liquid releaser 7 and the light liquid releaser 9 are both multi-layer annular wave cavity structures, each annular structure of the heavy liquid releaser 7 is provided with a heavy liquid release surface 74 and a heavy liquid vertical surface 75, each annular structure of the light liquid releaser 9 is provided with a light liquid vertical surface 91 and a light liquid release surface 92, the heavy liquid release surface 74 and the light liquid release surface 92 are inclined and arranged opposite to each other, and the heavy liquid release surface 74 and the light liquid release surface 92 are both provided with release holes; A light liquid inlet is provided at the bottom of the extraction tank 1, and a light liquid pipe 12 is connected to the output end of the light liquid inlet. The light liquid pipe 12 extends to the bottom of the light liquid releaser 9 and is connected thereto. A driving mechanism for driving the rotating kettle 6 to rotate centrifugally in the extraction tank 1 is provided at the top of the extraction tank 1. A heavy liquid pipe 8 is provided at the top of the rotating kettle 6. The heavy liquid pipe 8 is connected to the heavy liquid releaser 7. An adjusting mechanism for adjusting the staggered overlapping spacing between the heavy liquid releaser 7 and the light liquid releaser 9 is also provided at the top of the rotating kettle 6.

[0025] Before extraction in this system, the raw materials need to be put into the extraction tank. Each tank of dry yew is filled with about 1.5 tons of raw materials, and about 4.3 tons of methanol are added for leaching. The temperature is 42-50℃, and each cycle of leaching is more than 3 hours. After the leaching is completed, the extract is discharged into the extract storage tank for steam blowing. The temperature is controlled at 70-90℃ and the pressure is less than 0.2Mpa. The residual methanol solution is recovered. After the slag blowing is completed, the waste residue is moved to the waste yard for centralized treatment, and then concentrated. The concentration temperature is controlled at 50-65℃ and the vacuum degree is controlled at -0.07±00.1Mpa. When the extract is concentrated to a specific gravity of 0.95~1.05, the concentrate is released into a dedicated storage tank.

[0026] Then, the measured leaching concentrate is injected into the extraction tank 1, ethyl acetate is added (material: ethyl acetate = 1:1), extracted three times, and evaporated, condensed and collected through the evaporation tower 4 and the condensation tower 2.

[0027] It should be noted that, in the present embodiment, the driving mechanism is a stirring motor 5 fixed on the top of the extraction tank 1, the driving shaft of the stirring motor 5 extends into the extraction tank 1 and is fixedly connected to the top of the rotating kettle 6, and the rotating kettle 6, the heavy liquid pipe 8, and the light liquid pipe 12 are all coaxially arranged with the driving shaft of the stirring motor 5.

[0028] Among them, an adjusting column 701 is fixed on the top of the heavy liquid releaser 7, a limiting ring 62 matching the adjusting column 701 is fixed on the top of the rotating kettle 6, the adjusting column 701 is slidably connected to the inner side of the limiting ring 62, and a reverse mechanism is fixed on the top of the rotating kettle 6 for driving the heavy liquid releaser 7 to rotate in the opposite direction of the rotation direction of the rotating kettle 6.

[0029] A tensioning spring 72 is fixed between the limit ring 62 and the adjusting column 701, and an electromagnetic ring 621 is fixed on both the limit ring 62 and the adjusting column 701. A flow meter 81 is also fixed on the heavy liquid pipe 8. The flow meter 81 and the electromagnetic ring 621 are electrically connected to the control cabinet 3 through wires. The tensioning spring 72 is a high-strength fatigue-resistant spring structure. The tensioning spring 72 has an elastic force that drives the heavy liquid releaser 7 to move upward and away from the light liquid releaser 9. The two electromagnetic rings 621 have magnetic repulsion when power is on.

[0030] In the extraction process of the present invention, the rotary kettle 6 in the extraction tank 1 rotates under the drive of the driving mechanism, and the heavy liquid releaser 7 in the rotary kettle 6 rotates in the opposite direction of the rotation direction of the rotary kettle 6 under the drive of the reverse mechanism. At this time, heavy liquid is input into the heavy liquid pipe 8, and the heavy liquid flow rate is measured by the flowmeter 81 and fed back to the control cabinet 3. The control cabinet 3 adjusts the magnetic attraction between the electromagnetic rings 621 according to the design value, and then uses the magnetic attraction between the electromagnetic rings 621 to drive the heavy liquid releaser 7 to overcome the tensioning spring 72 and drop to a spacing corresponding to the heavy liquid flow rate. At this time, the relative spacing between the heavy liquid releaser 7 and the light liquid releaser 9 is adjusted, and the staggered overlapping area of ​​the heavy liquid release surface 74 and the light liquid release surface 92 is changed. Under the drive of the reverse mechanism, the heavy liquid output by the heavy liquid releaser 7 uses centrifugal force to sputter out of the release hole, impacting the light liquid output by the light liquid releaser 9, and performing the extraction operation. At the same time, the relative rotation of the liquid releaser 7 and the rotary kettle 6 can realize the full stirring contact between the heavy liquid and the light liquid, thereby effectively improving the extraction efficiency; Since the contact area between the heavy liquid release surface 74 and the light liquid release surface 92 changes in real time with the metering data of the flow meter 81, the staggered overlapping area of ​​the heavy liquid release surface 74 and the light liquid release surface 92 can be adjusted in real time, and the rotation speed of the rotating kettle 6 and the heavy liquid releaser 7 can be adjusted in real time, thereby achieving precise delivery of heavy liquid and light liquid during the extraction process to avoid insufficient or excessive reaction materials. It has adaptive intelligent adjustability, market prospects, and is suitable for promotion and application.

[0031] The second implementation method:

[0032] The present invention provides a paclitaxel supercritical extraction system, please refer to Figure 1-9 , wherein the components identical or corresponding to those in Embodiment 1 are marked with the corresponding reference numerals in Embodiment 1. For the sake of simplicity, only the differences from Embodiment 1 are described below: The output end of the heavy liquid pipe 8 is also connected to a shunt pipe 82, which is used to evenly distribute the heavy liquid output from the heavy liquid pipe 8 to the heavy liquid releaser 7. The reverse mechanism includes a reverse motor fixed on the top of the rotary kettle 6, and a driving gear column 73 is fixed on the output end of the reverse motor. A driven gear ring 71 meshing with the driving gear column 73 is fixed on the top of the adjusting column 701.

[0033] It should be noted that, in this embodiment, a buoyancy box 901 is fixed to the bottom of the light liquid releaser 9 , and the buoyancy box 901 is a closed cavity structure. The light liquid pipe 12 passes through the buoyancy box 901 and is connected to the light liquid releaser 9 .

[0034] Through the design with the float 901, when the light liquid transported by the light liquid pipe 12 is transported to the light liquid releaser 9 and released through the light liquid release surface 92, the excess light liquid is filled between the light liquid releaser 9 and the rotary kettle 6, and then the buoyancy of the float 901 in the light liquid can be used to drive the light liquid releaser 9 to move upward, so as to achieve the purpose of automatically adjusting the distance between the light liquid releaser 9 and the heavy liquid releaser 7 according to the input amount of light liquid.

[0035] Furthermore, the rotating kettle 6 is spindle-shaped, and a rotating ring 61 is provided in the middle of the rotating kettle 6. Centrifugal slopes 611 are provided on the upper and lower sides of the rotating ring 61. A slip ring corresponding to the rotating ring 61 is provided on the inner wall of the extraction tank 1. The slip ring is a sealed slip ring structure. The extraction tank 1 is divided into two upper and lower sealed spaces by the slip ring. The upper sealed space is provided with a light liquid outlet, and the lower sealed space is provided with a heavy liquid outlet. The centrifugal slopes 611 are respectively connected to the corresponding sealed spaces. A filter screen plate 11 is also fixed to the bottom of the extraction tank 1. The extraction tank 1 is used to filter the heavy liquid separated by the centrifugal slope 611.

[0036] Among them, the centrifugal slope 611 is a permeable membrane structure. The light liquid and the heavy liquid after the extraction reaction will be stratified due to density. During the rotation of the rotary kettle 6, centrifugal force is generated, so that the light liquid and the heavy liquid are naturally stratified up and down along the centrifugal slope 611, and separated into a sealed space by centrifugal force, and separated by the light liquid outlet and the heavy liquid outlet, thereby effectively improving the separation efficiency after the extraction is reversed.

[0037] The above is only the best implementation method adopted by this application in combination with current actual needs, but the protection scope of this application is not limited to this.

Claims

1. A paclitaxel supercritical extraction system, comprising an extraction tank (1), a condensation tower (2), an evaporation tower (4) and a control cabinet (3), characterized in that: The extract of the extraction tank (1) is evaporated, condensed and collected in turn through an evaporation tower (4) and a condensation tower (2). The extraction tank (1) is provided with a rotary kettle (6) which is rotatably connected thereto. The rotary kettle (6) is used to adjust the mixing ratio of the extracted heavy liquid and the extracted light liquid. The rotary kettle (6) is provided with a heavy liquid releaser (7) and a light liquid releaser (9). The heavy liquid releaser (7) and the light liquid releaser (9) are arranged opposite to each other. The heavy liquid releaser (7) and the light liquid releaser (9) both present a multi-layer annular wave cavity structure. Each annular structure of the heavy liquid releaser (7) is provided with a heavy liquid release surface (74) and a heavy liquid vertical surface (75). Each annular structure of the light liquid releaser (9) is provided with a light liquid vertical surface (91) and a light liquid release surface (92). The heavy liquid release surface (74) and the light liquid release surface (92) are inclined and arranged opposite to each other. Release holes are provided on the heavy liquid release surface (74) and the light liquid release surface (92). The bottom of the extraction tank (1) is provided with a light liquid inlet, the output end of the light liquid inlet is connected to a light liquid pipe (12), the light liquid pipe (12) extends to the bottom of the light liquid releaser (9) and is connected thereto, the top of the extraction tank (1) is provided with a driving mechanism for driving the rotating kettle (6) to rotate centrifugally in the extraction tank (1), the top of the rotating kettle (6) is provided with a heavy liquid pipe (8), the heavy liquid pipe (8) is connected thereto and is connected thereto with the heavy liquid releaser (7), the top of the rotating kettle (6) is also provided with a regulating mechanism for staggered overlap of the heavy liquid releaser (7) and the light liquid releaser (9) The rotary kettle (6) is spindle-shaped, a rotary ring (61) is provided in the middle of the rotary kettle (6), centrifugal inclined surfaces (611) are provided on both upper and lower sides of the rotary ring (61), a slip ring corresponding to the rotary ring (61) is provided on the inner wall of the extraction tank (1), the slip ring is a sealing slip ring structure, the extraction tank (1) is divided into upper and lower sealed spaces by the slip ring, the sealed space located at the upper part is provided with a light liquid outlet, and the sealed space located at the lower part is provided with a heavy liquid outlet, and the centrifugal inclined surfaces (611) are respectively connected to the corresponding sealed spaces.

2. A paclitaxel supercritical extraction system according to claim 1, characterized in that: The driving mechanism is a stirring motor (5) fixed on the top of the extraction tank (1); the driving shaft of the stirring motor (5) extends into the extraction tank (1) and is fixedly connected to the top of the rotary kettle (6); the rotary kettle (6), the heavy liquid pipe (8), and the light liquid pipe (12) are all coaxially arranged with the driving shaft of the stirring motor (5).

3. A paclitaxel supercritical extraction system according to claim 1, characterized in that: An adjusting column (701) is fixed on the top of the heavy liquid releaser (7), a limiting ring (62) matching the adjusting column (701) is fixed on the top of the rotating kettle (6), the adjusting column (701) is slidably connected to the inner side of the limiting ring (62), and a reversing mechanism for driving the heavy liquid releaser (7) to rotate in the opposite direction of the rotating kettle (6) is fixed on the top of the rotating kettle (6).

4. A paclitaxel supercritical extraction system according to claim 3, characterized in that: A tension spring (72) is fixed between the limit ring (62) and the adjustment column (701), an electromagnetic ring (621) is fixed on both the limit ring (62) and the adjustment column (701), a flow meter (81) is also fixed on the heavy liquid pipe (8), and the flow meter (81) and the electromagnetic ring (621) are electrically connected to the control cabinet (3) through wires.

5. A paclitaxel supercritical extraction system according to claim 3, characterized in that: The tension spring (72) is a high-strength fatigue-resistant spring structure. The tension spring (72) has an elastic force that drives the heavy liquid releaser (7) to move upward and away from the light liquid releaser (9). The two electromagnetic rings (621) have a magnetic repulsion force when powered.

6. A paclitaxel supercritical extraction system according to claim 1, characterized in that: The output end of the heavy liquid pipe (8) is also connected to a shunt pipe (82), and the shunt pipe (82) is used to evenly distribute the heavy liquid output from the heavy liquid pipe (8) into the heavy liquid releaser (7).

7. A paclitaxel supercritical extraction system according to claim 3, characterized in that: The reverse mechanism comprises a reverse motor fixed on the top of the rotary kettle (6), a driving gear column (73) is fixed on the output end of the reverse motor, and a driven gear ring (71) meshing with the driving gear column (73) is fixed on the top of the adjustment column (701).

8. The paclitaxel supercritical extraction system according to claim 1, characterized in that: A buoyancy box (901) is fixed at the bottom of the light liquid releaser (9), and the buoyancy box (901) is a closed cavity structure. The light liquid pipe (12) passes through the buoyancy box (901) and is connected to the light liquid releaser (9).

9. A paclitaxel supercritical extraction system according to claim 1, characterized in that: A filter screen plate (11) is also fixed to the bottom of the extraction tank (1), and the extraction tank (1) is used to filter the heavy liquid separated by centrifugation on the centrifugal inclined surface (611).

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