Process for synthesizing alpha-sodium formyl-beta-formylaminopropionitrile by using liquid sodium methoxide and application thereof

Abstract

The invention provides a process for synthesizing alpha-sodium formyl-beta-formylaminopropionitrile by using liquid sodium methoxide and application of the process, and relates to the technical field of synthesis of alpha-sodium formyl-beta-formylaminopropionitrile, the process comprises the following steps: pre-acylating beta-aminopropionitrile and methyl formate to obtain beta-formylaminopropionitrile, adding methyl formate into the beta-formylaminopropionitrile, and reacting to obtain alpha-sodium formyl-beta-formylaminopropionitrile; the method comprises the following steps: taking beta-formylaminopropionitrile, adding liquid sodium methoxide into the beta-formylaminopropionitrile, mixing to obtain beta-formylaminopropionitrile sodium salt, and formylating the beta-formylaminopropionitrile sodium salt and methyl formate to obtain the alpha-sodium formyl-beta-formylaminopropionitrile. The invention solves the technical problems of high loss rate of methyl formate, high process safety risk caused by carbon monoxide, and difficult control of operation environment caused by moisture absorption spontaneous combustion of solid sodium methylate and dust drifting during synthesis of alpha-sodium formyl-beta-formylaminopropionitrile in the prior art.

Description

Technical Field

[0001] The invention relates to the technical field of synthesis of α-sodium formyl-β-formylamino propionitrile, in particular to a process for synthesizing α-sodium formyl-β-formylamino propionitrile by utilizing liquid sodium methoxide and application thereof. Background Art

[0002] At present, the process for synthesizing α-sodium formyl-β-formylaminopropionitrile by sodium methoxide is as follows: first, 1 mol of aminopropionitrile is mixed with 4.5 mol of methyl formate, and then the temperature is controlled at 0-8°C, and 1.3 mol of solid sodium methoxide is slowly added. After the addition is completed, the resulting mixed solution is added to an autoclave, the temperature is raised to 60°C, the pressure is controlled to be about 2MPa, and the reaction is kept warm for 6 hours, and then the temperature is lowered to below 20°C, the crude α-sodium formyl-β-formylaminopropionitrile is filtered out, and then a small amount of methyl formate is used for rinsing and drying to obtain the finished α-sodium formyl-β-formylaminopropionitrile (abbreviated as sodium formyl).

[0003] However, the above process has the following disadvantages: during the process of feeding solid sodium methoxide, due to the presence of a large amount of methyl formate, it will react with sodium methoxide, resulting in the decomposition of part of the methyl formate, resulting in a high loss rate of methyl formate; at the same time, the decomposition process will produce a large amount of carbon monoxide, resulting in a high process safety risk; in addition, solid sodium methoxide is prone to spontaneous combustion after absorbing moisture, which poses a certain safety risk, and the labor intensity of feeding solid sodium methoxide is high, and the dust spreading will also make the on-site operating environment difficult to control.

[0004] In view of this, the present invention is proposed. Summary of the invention

[0005] One of the purposes of the present invention is to provide a process for synthesizing α-sodium formyl-β-formylaminopropionitrile by using liquid sodium methoxide, which can solve the technical problems in the prior art that the methyl formate loss rate is high during the synthesis of α-sodium formyl-β-formylaminopropionitrile, the process safety risk caused by carbon monoxide is high, and the solid sodium methoxide absorbs moisture and spontaneously ignites, and the dust is scattered, causing the operating environment to be difficult to control.

[0006] The second object of the present invention is to provide an application of a process for synthesizing α-sodium formyl-β-formylamino propionitrile by using liquid sodium methoxide, which is beneficial to avoiding the loss of methyl formate, improving production safety and reducing manual labor intensity, and is also beneficial to controlling the on-site operating environment.

[0007] In order to achieve the above-mentioned purpose of the present invention, the following technical solutions are particularly adopted:

[0008] In the first aspect, a process for synthesizing α-sodium formyl-β-formylamino propionitrile using liquid sodium methoxide comprises the following steps:

[0009] β-aminopropionitrile is first pre-acylated with methyl formate to obtain β-formylaminopropionitrile, and then the β-formylaminopropionitrile is added into liquid sodium methoxide to obtain β-formylaminopropionitrile sodium salt, and then the β-formylaminopropionitrile sodium salt is formylated with methyl formate to obtain the α-sodium formyl-β-formylaminopropionitrile.

[0010] Furthermore, the molar ratio of β-aminopropionitrile to methyl formate in the preacylation is 1:1.01.

[0011] Furthermore, the molar ratio of the sodium methoxide to β-aminopropionitrile is 1.3:1.

[0012] Furthermore, the molar ratio of methyl formate to β-aminopropionitrile in the formylation is 3.5:1.

[0013] Further, the formylation temperature is 55°C-65°C;

[0014] The formylation time is 5 hours to 7 hours.

[0015] Further, the formylation temperature is 60°C;

[0016] The formylation time was 6 hours.

[0017] Furthermore, the formylation pressure is 1 MPa-3 MPa.

[0018] Furthermore, the formylation pressure is 2 MPa.

[0019] Furthermore, before the formylation, the process also includes a step of concentrating the methanol mixed in the sodium salt of β-formylaminopropionitrile.

[0020] A second aspect is an application of any of the above-mentioned processes in chemical production.

[0021] Compared with the prior art, the present invention has at least the following beneficial effects:

[0022] The process for synthesizing α-sodium formyl-β-formylaminopropionitrile by using liquid sodium methoxide provided by the present invention adopts a step-by-step reaction mode, firstly pre-acylates β-aminopropionitrile with methyl formate to generate a mixed solution of β-formylaminopropionitrile and methanol, and then adds liquid sodium methoxide to the mixed solution to pre-mix it into a sodium salt. Since there is substantially no methyl formate in the system after the reaction, when pre-mixing with liquid sodium methoxide, the problem of methyl formate loss caused by the reaction and decomposition of methyl formate with sodium methoxide can be effectively avoided, and at the same time, no excessive methyl formate is decomposed by the reaction of sodium methoxide to generate carbon monoxide, and the carbon monoxide can be effectively reduced. The safety risk of the process is reduced; in addition, liquid sodium methoxide is used instead of solid sodium methoxide for premixing, and the liquid sodium methoxide can be fed in a closed pipeline, which can not only reduce the labor intensity of the operators, but also avoid the risk of spontaneous combustion due to moisture absorption during the feeding process of solid sodium methoxide, which effectively reduces the safety risk of the process, and there is no sodium methoxide dust floating in the closed pipeline feeding, which is conducive to improving the on-site operating environment; then, negative pressure concentration can be used to recover part of the methanol mixed in the sodium salt, and then the obtained concentrated solution is added with methyl formate for formylation, thereby obtaining α-sodium formyl-β-formylaminopropionitrile;

[0023] The application of the process for synthesizing α-sodium formyl-β-formylaminopropionitrile by using liquid sodium methoxide provided by the present invention is beneficial to avoiding the loss of methyl formate, improving production safety and reducing manual labor intensity, and is also beneficial to controlling the on-site operating environment. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] In order to more clearly illustrate the specific implementation methods of the present invention or the technical solutions in the prior art, the drawings required for use in the specific implementation methods or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are some implementation methods of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0025] Figure 1 A schematic diagram of a preacylation reaction provided in one embodiment of the present invention;

[0026] Figure 2 A schematic diagram of a reaction of adding liquid sodium methoxide to β-formylaminopropionitrile to premix the sodium salt provided in one embodiment of the present invention;

[0027] Figure 3 A schematic diagram of a formylation reaction provided in one embodiment of the present invention. DETAILED DESCRIPTION

[0028] The technical solution of the present invention will be clearly and completely described below in conjunction with the embodiments. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0029] According to a first aspect of the present invention, there is provided a process for synthesizing α-sodium formyl-β-formylamino propionitrile using liquid sodium methoxide, comprising the following steps:

[0030] β-aminopropionitrile was pre-acylated with methyl formate. Figure 1 , to obtain β-formylaminopropionitrile, and then take the β-formylaminopropionitrile and add liquid sodium methoxide to mix, see Figure 2 , to obtain β-formylaminopropionitrile sodium salt, and then the β-formylaminopropionitrile sodium salt is formylated with methyl formate, see Figure 3 , to obtain α-sodium formyl-β-formylaminopropionitrile.

[0031] The invention adopts a step-by-step reaction mode, which not only reduces the problem of high methyl formate loss rate in the premixing process, but also avoids the potential safety hazard caused by carbon monoxide generated by the decomposition of methyl formate. In addition, liquid sodium methoxide is used to replace solid sodium methoxide, which not only reduces manual labor intensity, but also improves the on-site operating environment, and eliminates the potential safety hazard caused by spontaneous combustion of solid sodium methoxide due to moisture absorption.

[0032] In a preferred embodiment, the molar ratio of β-aminopropionitrile to methyl formate in the preacylation may be 1:1.01, but is not limited thereto; the molar ratio of sodium methoxide to β-aminopropionitrile may be 1.3:1, but is not limited thereto; the molar ratio of methyl formate to β-aminopropionitrile in the formylation may be 3.5:1, but is not limited thereto.

[0033] The molar ratio of the raw materials in the present invention can ensure that there is substantially no excess methyl formate in the reaction system, and when the raw materials are premixed with liquid sodium methoxide, the problem of methyl formate loss caused by the decomposition of methyl formate and sodium methoxide is avoided, and the generation of carbon monoxide by the reaction of methyl formate and sodium methoxide is avoided, which is beneficial to reducing the safety risk of the process, and can ensure that the alpha-sodium formyl-beta-formylaminopropionitrile has a higher reaction yield.

[0034] In a preferred embodiment, the formylation temperature can be 55°C-65°C, and typical but non-limiting temperatures include 55°C, 56°C, 57°C, 58°C, 59°C, 60°C, 61°C, 62°C, 63°C, 64°C, and 65°C; the formylation time can be 5 hours to 7 hours, and typical but non-limiting times include 5 hours, 6 hours, and 7 hours.

[0035] In a preferred embodiment, the formylation temperature may be 60° C. and the formylation time may be 6 hours, which is more conducive to sufficient formylation and more conducive to further improving the reaction yield of α-sodium formyl-β-formylaminopropionitrile.

[0036] In a preferred embodiment, the formylation pressure can be 1 MPa-3 MPa, and its typical but non-limiting pressure is, for example, 1 MPa, 2 MPa, 3 MPa, and can be further preferably 2 MPa, which is more conducive to further improving the reaction yield of α-sodium formyl-β-formylaminopropionitrile.

[0037] In the present invention, the step of concentrating the methanol mixed in the sodium salt of β-formylaminopropionitrile is further included before formylation, which is more conducive to sufficient formylation.

[0038] A typical process for synthesizing α-sodium formyl-β-formylamino propionitrile using liquid sodium methoxide comprises the following steps:

[0039] 1 mol of β-aminopropionitrile is first mixed with 1.01 mol of methyl formate for pre-acylation reaction to generate a mixed solution of β-formylaminopropionitrile and methanol, and then the mixed solution is added with 1.3 mol of liquid sodium methoxide to pre-mix into sodium salt, and then a part of the methanol generated by the reaction is collected by negative pressure concentration, and the concentrated amount is 71% of the amount of methanol in the liquid sodium methoxide. The concentrated solution obtained by concentration is then added to an autoclave, and 3.5 mol of methyl formate is pumped into the autoclave, and then the temperature is raised to 60° C. and reacted for 6 hours under insulation, while controlling the pressure to 2 MPa. After the reaction is completed, the temperature is lowered to below 20° C. to filter out the crude α-sodium formyl-β-formylaminopropionitrile product, and after rinsing with a small amount of methyl formate, the product is dried to obtain the finished α-sodium formyl-β-formylaminopropionitrile (abbreviated as sodium formyl).

[0040] According to a second aspect of the present invention, there is provided an application of any of the above-mentioned processes in chemical production.

[0041] The application of the process for synthesizing α-sodium formyl-β-formylaminopropionitrile by using liquid sodium methoxide provided by the present invention is beneficial to avoiding the loss of methyl formate, improving production safety and reducing manual labor intensity, and is also beneficial to controlling the on-site operating environment.

[0042] The present invention is further described below by way of examples. Unless otherwise specified, the materials in the examples are prepared according to existing methods or directly purchased from the market.

[0043] Example 1

[0044] A process for synthesizing α-sodium formyl-β-formylaminopropionitrile using liquid sodium methoxide, wherein the process parameters and product yield are shown in Table 1, comprises the following steps:

[0045] (1) Add 150 g of β-aminopropionitrile and 137 g of methyl formate (content 95%) into a 500 ml pre-acylation reaction flask, start stirring, and react at a temperature of 35° C. for 6 hours to obtain a mixed solution of β-formylaminopropionitrile and methanol;

[0046] (2) Add 520 g of liquid sodium methoxide (content 29%) to a 1000 ml rotary evaporation flask, and add the mixed solution of β-formylaminopropionitrile and methanol obtained in step (1) under stirring;

[0047] (3) using negative pressure to concentrate and condense the material in the 1000 ml rotary evaporator to collect 369 g of methanol, and the concentrated hot water temperature is 80° C. to obtain a concentrated β-formylaminopropionitrile sodium salt methanol solution;

[0048] (4) pouring the solution obtained in step (3) into a 1000 ml high pressure reactor;

[0049] (5) 463 g of methyl formate was pumped into the autoclave of step (4) using a high-pressure pump, and then the temperature was raised to 65° C., the pressure in the autoclave was 2.6 MPa, and the reaction was carried out under heat preservation for 6 hours;

[0050] (6) After the heat preservation reaction is completed, the temperature of the materials in the high-pressure reactor is lowered to below 20°C;

[0051] (7) After the autoclave is discharged, the contents are filtered and the resulting filter cake is rinsed with 100 g of methyl formate;

[0052] (8) The filtered cake was dried to obtain 352 g of α-sodium-substituted formyl-β-formylaminopropionitrile product (i.e., sodium-substituted product), with a detected content of 79% and a yield of 87.7%.

[0053] Example 2

[0054] A process for synthesizing α-sodium formyl-β-formylaminopropionitrile using liquid sodium methoxide, wherein the process parameters and product yield are shown in Table 1, comprises the following steps:

[0055] (1) Add 150 g of β-aminopropionitrile and 137 g of methyl formate (content 95%) into a 500 ml pre-acylation reaction flask, start stirring, and react at a temperature of 35° C. for 6 hours to obtain a mixed solution of β-formylaminopropionitrile and methanol;

[0056] (2) Add 520 g of liquid sodium methoxide (content 29%) to a 1000 ml rotary evaporation flask, and add the mixed solution of β-formylaminopropionitrile and methanol obtained in step (1) under stirring;

[0057] (3) using negative pressure to concentrate and condense the material in the 1000 ml rotary evaporator to collect 369 g of methanol, and the concentrated hot water temperature is 50° C. to obtain a concentrated β-formylaminopropionitrile sodium salt methanol solution;

[0058] (4) pouring the solution obtained in step (3) into a 1000 ml high pressure reactor;

[0059] (5) 463 g of methyl formate was pumped into the autoclave of step (4) using a high-pressure pump, and then the temperature was raised to 60° C., the pressure in the autoclave was 2 MPa, and the reaction was carried out under heat preservation for 6 hours;

[0060] (6) After the heat preservation reaction is completed, the temperature of the materials in the high-pressure reactor is lowered to below 20°C;

[0061] (7) After the autoclave is discharged, the contents are filtered and the resulting filter cake is rinsed with 100 g of methyl formate;

[0062] (8) The filtered cake was dried to obtain 360 g of α-sodium-substituted formyl-β-formylaminopropionitrile product (i.e., sodium-substituted product), with a detected content of 80% and a yield of 90.87%.

[0063] Comparative Example 1

[0064] A process for synthesizing α-sodium formyl-β-formylamino propionitrile, the process parameters and product yield are shown in Table 1, comprising the following steps:

[0065] (1) Premixing: Add 150 g of β-aminopropionitrile and 600 g of methyl formate (content 95%) to a 1000 ml reaction flask, start stirring, place the reaction flask in a freezer to cool to 5° C.-8° C., then slowly add 157 g of solid sodium methoxide (content 96%). This process must be completed in a fume hood because methyl formate continues to decompose to produce carbon monoxide.

[0066] (2) Reaction: After the premixing and feeding is completed, the materials in the premixing reaction flask are added to a 1000 ml high-pressure reactor, and then the reactor is heated to 60° C., the pressure in the reactor is 2 MPa, and the reaction is carried out under heat preservation for 6 hours;

[0067] (3) After the heat preservation reaction is completed, the temperature of the materials in the high-pressure reactor is lowered to below 20°C, and then the residual pressure in the reactor is discharged. The residual pressure in the reactor is the carbon monoxide produced by the decomposition of methyl formate, and it needs to be discharged into a fume hood;

[0068] (4) After the autoclave is discharged, the material in the autoclave is filtered and the filter cake is rinsed with 100 g of methyl formate;

[0069] (5) The filtered cake was dried to obtain 353 g of α-sodium-substituted formyl-β-formylaminopropionitrile product (i.e., sodium-substituted product), with a detected content of 79.5% and a yield of 89.05%.

[0070] Comparative Example 2

[0071] A process for synthesizing α-sodium formyl-β-formylamino propionitrile, the process parameters and product yield are shown in Table 1, comprising the following steps:

[0072] (1) Add 150 g of β-aminopropionitrile and 520 g of liquid sodium methoxide (content 29%) into a 1000 ml autoclave and start stirring;

[0073] (2) Then, 30 kg / cm 2 G of CO (carbon monoxide), then the temperature is raised to 60°C, the pressure in the reactor is 30Mpa, and the reaction is carried out under insulation for 10 hours;

[0074] (3) After the heat preservation reaction is completed, the temperature of the materials in the high-pressure reactor is lowered to below 20° C., and then the residual pressure in the reactor is released;

[0075] (4) After the autoclave is discharged, the material in the autoclave is filtered and the filter cake is rinsed with 100 g of methyl formate;

[0076] (5) The filtered cake was dried to obtain 350 g of α-sodium-substituted formyl-β-formylaminopropionitrile finished product (i.e., sodium-substituted product), with a detected content of 80% and a yield of 88.35%.

[0077] Comparative Example 3

[0078] A process for synthesizing α-sodium formyl-β-formylamino propionitrile, the process parameters and product yield are shown in Table 1, comprising the following steps:

[0079] (1) Add 150 g of β-aminopropionitrile and 520 g of liquid sodium methoxide (content 29%) into a 1000 ml autoclave and start stirring;

[0080] (2) Then, 50 kg / cm 2 G of CO (carbon monoxide), then the temperature is raised to 60°C, the pressure in the reactor is 50Mpa, and the reaction is carried out under insulation for 10 hours;

[0081] (3) After the heat preservation reaction is completed, the temperature of the materials in the high-pressure reactor is lowered to below 20° C., and then the residual pressure in the reactor is released;

[0082] (4) After the autoclave is discharged, the material in the autoclave is filtered and the filter cake is rinsed with 100 g of methyl formate;

[0083] (5) The filtered cake was dried to obtain 358 g of α-sodium-substituted formyl-β-formylaminopropionitrile finished product (i.e., sodium-substituted product), with a detected content of 79.5% and a yield of 89.8%.

[0084] Table 1

[0085]

[0086] As can be seen from the above data results, in the process of Comparative Example 1, 1 mol of β-aminopropionitrile was mixed with 4.5 mol of methyl formate, and then 1.3 mol of solid sodium methoxide was added. After heating to 60 ℃ and keeping warm for 6 hours, the temperature was lowered, filtered and dried to obtain 353g of sodium-substituted product with a content of 79.5% and a yield of 89.05%. When the process is premixed, methyl formate decomposes to produce a certain amount of carbon monoxide, resulting in certain safety hazards. The addition of solid sodium methoxide causes the labor intensity of the operator to be large, and solid sodium methoxide is easy to absorb moisture and spontaneously combust, which has certain safety hazards. In the process of Comparative Example 2, 1 mol of β-aminopropionitrile was mixed with 1.3 mol of liquid sodium methoxide, and then carbon monoxide was introduced. After heating to 60 ℃ and keeping warm for 10 hours, the temperature was lowered, filtered and dried to obtain 350g of sodium-substituted product with a content of 80% and a yield of 88.35%. Although the process uses The use of liquid sodium methoxide eliminates the generation of carbon monoxide during the premixing process, reduces the labor intensity of adding solid sodium methoxide, and avoids the risk of spontaneous combustion of solid sodium methoxide due to moisture absorption. However, the process requires the introduction of carbon monoxide to first carbonylate the methanol in the liquid sodium methoxide to generate methyl formate, and then the methyl formate reacts with aminopropionitrile. The introduction of carbon monoxide requires high operating pressure and a long reaction cycle. In the process of Comparative Example 3, 1 mol of β-aminopropionitrile is mixed with 1.3 mol of liquid sodium methoxide, and then carbon monoxide is introduced. The temperature is raised to 60°C and kept warm for 10 hours, then cooled, filtered and dried to obtain 358 g of sodium product with a content of 79.5% and a yield of 89.8%. Although the carbon monoxide introduction pressure is increased and the sodium recovery rate is slightly improved, the introduction of carbon monoxide requires higher operating pressure and a long reaction cycle.

[0087] In the process of Example 1, β-aminopropionitrile and methyl formate are first subjected to a pre-acylation reaction in a molar ratio of 1:1.01 to generate a mixed solution of β-formylaminopropionitrile and methanol, to which 1.3 moles of liquid sodium methoxide are added, and then a portion of the methanol generated by the reaction is collected by negative pressure concentration, the concentrated amount being 71% of the amount of methanol in the liquid sodium methoxide (concentration temperature 80°C), after which the concentrated solution is added to an autoclave, and 3.5 moles of methyl formate are pumped into the autoclave, and then the temperature is raised to 65°C and kept for 6 hours, then cooled, filtered and dried to obtain 352g of a sodium-substituted product with a content of 79% and a yield of 87.7%. The process adopts a step-by-step reaction, wherein aminopropionitrile and an equal molar amount of methyl formate are first pre-acylated to generate formylaminopropionitrile and methanol, which are then premixed with liquid sodium methoxide, and the premixing process completely eliminates the decomposition loss of methyl formate and the potential safety hazards caused by the output of carbon monoxide, and the premixing process uses Liquid sodium methoxide completely avoids the labor intensity of adding solid sodium methoxide, and also avoids the risk of spontaneous combustion of solid sodium methoxide due to moisture absorption, and the process can realize the application of liquid sodium methoxide in the sodium generation synthesis process without using carbon monoxide; in the process of Example 2, β-aminopropionitrile and methyl formate are first subjected to a pre-acylation reaction at a molar ratio of 1:1.01 to generate a mixed solution of β-formylaminopropionitrile and methanol, to which 1.3 moles of liquid sodium methoxide are added, and then a part of the methanol generated by the reaction is collected by negative pressure concentration, and the concentrated amount is 71% of the methanol amount in the liquid sodium methoxide (concentration temperature is 50°C), and then the concentrated solution is added to a high-pressure reactor, and then 3.5 moles of methyl formate is pumped into the high-pressure reactor, and then the temperature is raised to 60°C and kept for 6 hours, and then the temperature is lowered, filtered and dried to obtain 360g of a sodium generation product with a content of 80% and a yield of 90.87%. Compared with Example 1, the yield of the sodium generation product of the process is higher.

[0088] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A process for synthesizing α-sodium formyl-β-formylamino propionitrile using liquid sodium methoxide, characterized in that: The following steps are involved: β-aminopropionitrile is first pre-acylated with methyl formate to obtain β-formylaminopropionitrile, and then the β-formylaminopropionitrile is added into liquid sodium methoxide to obtain β-formylaminopropionitrile sodium salt, and then the β-formylaminopropionitrile sodium salt is formylated with methyl formate to obtain the α-sodium formyl-β-formylaminopropionitrile.

2. The process according to claim 1, characterized in that The molar ratio of β-aminopropionitrile to methyl formate in the preacylation is 1:1.

01.

3. The process according to claim 2, characterized in that The molar ratio of the sodium methoxide to β-aminopropionitrile is 1.3:

1.

4. The process according to claim 3, characterized in that The molar ratio of methyl formate to β-aminopropionitrile in the formylation is 3.5:

1.

5. The process according to any one of claims 1 to 4, characterized in that The formylation temperature is 55°C-65°C; The formylation time is 5 hours to 7 hours.

6. The process according to claim 5, characterized in that The formylation temperature is 60°C; The formylation time was 6 hours.

7. The process according to claim 5, characterized in that The formylation pressure is 1 MPa-3 MPa.

8. The process according to claim 7, characterized in that The formylation pressure was 2 MPa.

9. The process according to claim 1, characterized in that The method also includes the step of concentrating the methanol mixed in the sodium salt of β-formylaminopropionitrile before the formylation.

10. Use of the process according to any one of claims 1 to 9 in chemical production.

Images