Compound synergistic active insecticide

Abstract

The invention belongs to the technical field of insecticides, and particularly relates to a compound synergistic active insecticide. The invention relates to a compound synergistic active insecticidal composition. The active component of the compound synergistic active insecticidal composition is prepared by compounding an active component a and an active component b according to a mass ratio of (1-100): (200-1), the active ingredient a is diethyl aminoethyl hexanoate; and the active ingredient b is guadipyr or spinetoram. The diethylaminoethyl hexanoate and the guadipyr or the spinetoram are compounded, the killing effect of the diethylaminoethyl hexanoate and the guadipyr or the spinetoram is superior to that of single diethylaminoethyl hexanoate, guadipyr or spinetoram, and it is indicated that the insecticidal composition has high activity, and the prevention and removal effect on crop pests can be improved. On the basis, the dosage of the pesticide in unit area can be reduced, so that the problems of environmental pollution, pesticide residues and the like are relieved, and the method has important significance for developing green and efficient novel pesticides.

Description

Technical Field

[0001] The invention belongs to the technical field of insecticides, and in particular relates to a compound synergistic active insecticide. Background Art

[0002] Penpyrafenib is a novel neonicotinoid insecticide developed in my country. It cleverly combines the active structures of neonicotinoids and semicarbazone insecticides into the same molecule to obtain a nitroaminoguanidine insecticide with the insecticidal activity characteristics of both neonicotinoids and sodium channel inhibitors 2. Penpyrafenib is effective against all developmental stages of pests, including eggs, through contact killing. It has the characteristics of a broad insecticidal spectrum, rapid effect and high efficiency, and has multiple targets, and is friendly to the environment and non-target organisms.

[0003] Spinetoram is a macrolide antibiotic insecticide developed by Dow AgroSciences, USA. Its mechanism of action is nicotinic acetylcholine receptors. It stimulates the nervous system of pests by changing the function of aminobutyric acid ion channels and nicotine, causing system paralysis and leading to the death of pests. Spinetoram can be used to control leaf miners, western flower thrips, thrips, beet armyworms, pear borers, cotton bollworms, corn borers, citrus fruit flies, pear psyllids and tobacco budworms on crops such as cruciferous crops, vegetables, fruit trees, grapes, corn, soybeans, sugarcane, strawberries and cotton. Spinetoram is a biological insecticide purified from the metabolites of actinomycetes, with low toxicity, low residual amount in the environment and good environmental compatibility.

[0004] Although pyrimidine and spinetoram have the above advantages, the long-term use of these two pesticides alone has caused various target pests to develop resistance to them to varying degrees, resulting in reduced or even ineffective control of the pesticides. Although increasing the dosage of pesticides per unit area can improve the control effect of the target in a short period of time, this will aggravate the resistance of target pests and also increase environmental pollution and pesticide residues. Therefore, it is necessary to develop new green and efficient pesticides.

[0005] Diethylaminoethyl is a plant growth regulator that can increase the activity of plant peroxidase and nitrate reductase, increase the content of chlorophyll to accelerate photosynthesis, promote the division and elongation of plant cells, promote the development of root system, and regulate the balance of nutrients in the body. Diethylaminoethyl can be compounded with multiple elements and can also be compounded with fungicides to enhance the disease resistance of plants and improve the bactericidal effect. The patent of prior art CN113367134A also discloses that diethylaminoethyl has a control effect on banana thrips.

[0006] So far, there are no reports on the combination of ampicillin and pyraclostrobin or spinetoram.

[0007] The information disclosed in this background technology section is only intended to enhance the understanding of the overall background of the invention and should not be regarded as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to a person skilled in the art. Summary of the invention

[0008] The object of the present invention is to provide a composite synergistic active insecticide to solve the problems existing in the use of pyraclostrobin or spinetoram alone.

[0009] To achieve the above object, the present invention provides the following technical solutions:

[0010] A compounded and synergistic active insecticide composition, wherein the active ingredients of the compounded and synergistic active insecticide composition are compounded by active ingredient a and active ingredient b in a mass ratio of 1-100:200-1; the active ingredient a is diethylaminoethyl hexanoate; and the active ingredient b is pyraclostrobin or spinetoram.

[0011] More specifically, when the active ingredient b is pyraclostrobin, the mass ratio of the active ingredient a to the active ingredient b is 1-5:60-1.

[0012] More specifically, when the active ingredient b is spinetoram, the mass ratio of the active ingredient a to the active ingredient b is 1:20-1.

[0013] The present invention also provides an insecticide, which is prepared by adding the active ingredients of the compounded synergistic active insecticide composition to auxiliary ingredients allowed to be added in pesticide science. It should be noted that the auxiliary ingredients allowed to be added in pesticide science include dispersants, wetting agents, fillers, solvents, cosolvents, disintegrants, binders, thickeners, defoamers, film formers, antifreeze agents, preservatives, colorants, synergists and other auxiliary ingredients.

[0014] More specifically, the mass of the active ingredients of the composite synergistic active insecticide composition accounts for 1-60% of the total mass of the insecticide.

[0015] Compared with the prior art, the present invention has the following beneficial effects:

[0016] (1) The present invention compounds diethylaminoethyl with pyrimidine or spinetoram, which is superior to single diethylaminoethyl, pyrimidine or spinetoram in killing agricultural pests such as western flower thrips and tobacco thrips, indicating that the insecticide combination of the present invention has high activity and can improve the control effect on crop pests. On this basis, the dosage of pesticides per unit area can be reduced, thereby alleviating problems such as environmental pollution and pesticide residues, which is of great significance for the development of green and efficient new pesticides.

[0017] (2) The mechanism of action of the aminoethyl hexadecene of the present invention is different from that of pyraclostrobin or spinetoram, and the risk of drug resistance caused by long-term single use can be overcome, and the service life of the agent can be extended, which is of great significance for the comprehensive control of crop pests. DETAILED DESCRIPTION

[0018] The following is a clear and complete description of the technical solution of the patent of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by technicians in this field without creative work are within the scope of protection of the present invention.

[0019] Example :Indoor biological activity test of diethylaminoethyl hexanoate compound

[0020] 1. Test reagents

[0021] 98% aminoethyl hexanoate technical (Zhengzhou Zhengshi Chemical Products Co., Ltd.), 96% pyraclostrobin technical (Hefei Xingyu Chemical Co., Ltd.), 81.2% spinetoram technical (Corteva Agricultural Technology Co., Ltd.)

[0022] The original drug of the test agent is first dissolved in dimethyl sulfoxide, and then diluted with a 0.1% Tween-80 aqueous solution to form a single-dose mother solution with a single-dose mother solution concentration of 5000 mg / L. Set up multiple groups of proportions, and each single dose and each group of mixed proportions are set with 5 gradient mass concentration gradients according to the equal ratio method, and each mass concentration solution is 50mL for standby; the above test agents are prepared and used immediately.

[0023] 2. Test pests

[0024] Western Flower Thrips and Nicotiana tabacum were collected from vegetable planting areas. After six generations of continuous feeding with fresh and clean cabbage leaves, 2nd instar nymphs of uniform size were selected as test subjects. Feeding conditions: temperature 25±1℃, relative humidity 60±5%, light-dark cycle 14h / 10h.

[0025] 3. Test method: (Refer to "NY / T 1154.6-2006 Pesticide Indoor Bioassay Test Guidelines Insecticides Part 6: Insecticide Activity Test Insect Immersion Method")

[0026] The test insects were immersed in the liquid for 10 seconds and then taken out. The excess liquid was absorbed with filter paper and then transferred to the original breeding conditions for breeding. Each treatment was repeated 3 times, and 30 insects were immersed in each repetition. The treatment containing only 0.1% Tween-80 aqueous solution was set as a blank control. After 48 hours of treatment, the death of the test insects was investigated, and the total number of insects and the number of dead insects in each treatment were recorded respectively. The corrected mortality rate of each treatment was calculated based on this. The DPS software was used to perform regression analysis on the logarithmic value of the concentration of each treatment agent and the corrected mortality probability value, and the LC of each treatment agent was calculated. 50 .

[0027] 4. Calculation method

[0028]

[0029] In the above formula: P--mortality rate, unit is %; K--number of dead insects; N--total number of insects treated.

[0030]

[0031] In the above formula: P1--corrected mortality rate, unit is %; P t --Treatment mortality rate, in %; P0--blank control mortality rate, in %.

[0032] 5. Pharmaceutical evaluation

[0033] The co-toxicity coefficient (CTC value) of the mixture was calculated according to the Sun Yunpei method, and the combined effect was divided according to the standard: co-toxicity coefficient (CTC) ≥ 120 showed synergistic effect; co-toxicity coefficient (CTC) ≤ 80 showed antagonistic effect; 80 < co-toxicity coefficient (CTC) < 120 showed additive effect. The results are shown in Table 1-2.

[0034] Table 1 Indoor bioactivity test of amikacin and pentamethylenetetracycline against western flower thrips

[0035]

[0036] As shown in Table 1, when the mass ratio is 1:60 or 5:1, the co-toxicity coefficient of the combination of ampicillin and pentamethylenetetracycline to western flower thrips is between 80-120, showing an additive effect; when the mass ratio is 1-3:40-1, the co-toxicity coefficient of the combination of ampicillin and pentamethylenetetracycline to western flower thrips is greater than 120, showing a synergistic effect, which can improve the control effect on western flower thrips, especially when the mass ratio is 1:10, the co-toxicity coefficient reaches 918.526, showing a significant synergistic effect.

[0037] Table 2 Indoor bioactivity test of aminoethyl hexanoate and spinetoram against Thrips tabaci

[0038]

[0039] It can be seen from Table 2 that when the mass ratio is 1:20 or 1:1, the co-toxicity coefficient of aminoethyl hexanoate and spinetoram on Thrips tabaci is between 80-120, showing an additive effect; when the mass ratio is 3:1, the co-toxicity coefficient of aminoethyl hexanoate and spinetoram on Thrips tabaci is less than 80, showing an antagonistic effect; when the mass ratio is 1:10-3, the co-toxicity coefficient of aminoethyl hexanoate and spinetoram on Thrips tabaci is greater than 120, showing a synergistic effect, which can improve the control effect on Thrips tabaci.

[0040] In summary, the present invention compounds diethylaminoethyl with pyrimidine or spinetoram, which is superior to single diethylaminoethyl, pyrimidine or spinetoram in killing agricultural pests such as western flower thrips and tobacco thrips, indicating that the insecticide combination of the present invention has high activity and can improve the control effect on crop pests. On this basis, the dosage of pesticides per unit area can be reduced, thereby alleviating problems such as environmental pollution and pesticide residues, which is of great significance to the development of green and efficient new pesticides.

Claims

1. A composite synergistic active insecticide composition, characterized in that: The active ingredient of the compounded synergistic active insecticide composition is compounded by active ingredient a and active ingredient b in a mass ratio of 1-100:200-1; The active ingredient a is diethylaminoethyl ester; The active ingredient b is pyraclostrobin or spinetoram.

2. The compounded synergistic active insecticide composition according to claim 1, characterized in that: When the active ingredient b is pyraclostrobin, the mass ratio of the active ingredient a to the active ingredient b is 1-5:60-1.

3. The compounded synergistic active insecticide composition according to claim 1, characterized in that: When the active ingredient b is spinetoram, the mass ratio of the active ingredient a to the active ingredient b is 1:20-1.

4. An insecticide, characterized in that The insecticide is prepared by using the active ingredients of the compound synergistic active insecticide composition according to any one of claims 1 to 3 and auxiliary ingredients allowed to be added in pesticide science.

5. The insecticide according to claim 4, characterized in that The mass of the active ingredients of the composite synergistic active insecticide composition accounts for 1-60% of the total mass of the insecticide.

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