Anti-hair loss essence and preparation method thereof

Abstract

The present application relates to the field of scalp nourishment, and discloses an anti-hair loss essence and a preparation method thereof. The anti-hair loss essence comprises component A, component B, component C, component D and component E, and the weight percentage of each component added is as follows: component A: thickener 0.4-0.6%, moisturizer 0.3-0.7%, and solvent supplemented to 100%; component B: skin protectant (1) 1.5-3.5%, niacinamide 0.3-0.7%, skin protectant (2) 0.08-0.12%; component C: solvent 35-45%, fragrance 0.1-0.3%, tetrahydropiperine 0.03-0.07%, matrine 0.005-0.015%; component D: anti-hair loss agent 4-6%, preservative 0.3-1.0%; component E: skin penetrant 0.01-0.1%. The anti-hair loss essence has the advantages of improving the scalp's absorption effect on the traditional Chinese medicine composition, improving scalp health, and reducing hair loss.

Description

Technical Field

[0001] The present application relates to the technical field of scalp nourishment, and in particular to an anti-hair loss essence and a preparation method thereof. Background Art

[0002] With the development of society, the pressure of life and work is increasing. Coupled with irregular work and rest schedules, as well as external factors such as environmental pollution, the number of people suffering from hair loss in my country is increasing, and the age of hair loss is getting younger and younger, forcing people to pay attention to the problem of hair loss. Currently, treatments such as anti-hair loss drugs and hair transplants are expensive. During the treatment process, if the hair is not properly cared for or exposed to external stimuli, it may cause hair loss again.

[0003] To prevent or improve hair loss, anti-hair loss products containing Chinese herbal extracts have emerged on the market. These products significantly reduce the scalp's irritation and can improve scalp health, hair quality, and hair loss prevention and growth. However, due to the scalp's inadequate absorption of these extracts, the herbs are often wasted, resulting in significant discrepancies between the expected effectiveness and the desired results. Summary of the Invention

[0004] In order to improve the scalp's absorption effect on the traditional Chinese medicine composition, the present application provides an anti-hair loss essence and a preparation method thereof.

[0005] In the first aspect, the present application provides an anti-hair loss essence lotion, which adopts the following technical solution:

[0006] An anti-hair loss essence lotion comprises component A, component B, component C, component D and component E. The total weight percentage of the raw materials in each component is 100%, and the weight percentage of each component added is as follows:

[0007] Component A: 0.4-0.6% thickener, 0.3-0.7% moisturizer, and solvent to make up to 100% of the weight of the anti-hair loss essence, the solvent is water;

[0008] Component B: skin protectant (1) 1.5-3.5%, niacinamide 0.3-0.7%, skin protectant (2) 0.08-0.12%;

[0009] The skin protectant (1) is prepared from the following raw materials in percentage by weight: 3-7% of Polygonum multiflorum root extract, 2-4% of propylene glycol, 0.4-0.8% of 1,2-hexanediol, 0.4-0.7% of phenoxyethanol, 0.04-0.08% of ethylhexylglycerin, and water is added to 100% of the weight of the skin protectant (1);

[0010] The skin protectant (2) is prepared from the following raw materials in percentage by weight: 10-20% glycerin, 1-4% tea extract, 0.4-0.8% 1,2-hexanediol, 0.3-0.7% phenoxyethanol, 0.04-0.08% ethylhexylglycerin, and water is added to make up to 100% of the weight of the skin protectant (2);

[0011] Component C: solvent 35-45%, fragrance 0.1-0.3%, tetrahydropiperine 0.03-0.07%, matrine 0.005-0.015%;

[0012] Component D: anti-hair loss agent 4-6%, preservative 0.3-1.0%;

[0013] The anti-hair loss agent is prepared from the following raw materials in percentage by weight: 15-21% 1,3-propylene glycol, 15-21% Platycladus orientalis leaf extract, 0.4-0.8% hydrogenated castor oil, 0.08-0.12% disodium EDTA, and water is added to 100% of the weight of the anti-hair loss agent; component E: 0.01-0.1% skin penetrant; the skin penetrant is prepared from the following raw materials in percentage by weight: 50-90% poloxamer and 10-50% sodium hyaluronate.

[0014] By adopting the above technical solution, this application mainly reduces hair loss by repairing hair follicles and soothing the scalp, and improving the health of the scalp and hair follicles. Poloxamer is a new type of high molecular non-ionic surfactant, which is a polyoxyethylene polyoxypropylene ether block polymer. It is often used as a pharmaceutical excipient for oral use. It can play the role of emulsification stabilization, solubilization, absorption promotion, sustained release, solid dispersant, etc. It is non-irritating to the skin and non-hemolytic. Studies have found that when poloxamer and sodium hyaluronate are simultaneously applied to the anti-hair loss essence, the mutual synergistic effect of the two substances greatly improves the anti-hair loss effect of the anti-hair loss essence. Sodium hyaluronate is a physiologically active substance widely present in animals and humans. It is distributed in human skin, synovial fluid, umbilical cord, aqueous humor and vitreous body. When applied to anti-hair loss serums, it was found to be highly moisturizing for the scalp. Adding it together with poloxamer revealed that sodium hyaluronate acts as a penetrating and infusion solution. Furthermore, poloxamer itself possesses excellent biocompatibility, allowing poloxamer to penetrate into pores, opening and relaxing them. This allows macromolecular nutrients to penetrate deeper into the skin, thereby promoting their absorption. The moisturizing effect of sodium hyaluronate can moisturize the area around hair follicles, preventing nutrient loss and prolonging their duration of action, thereby improving scalp health.

[0015] Preferably, the skin penetrant is prepared from the following raw materials in parts by weight: 70% poloxamer and 30% sodium hyaluronate.

[0016] By adopting the above technical solution, the addition ratio of poloxamer and sodium hyaluronate is also a very critical influencing factor. By adjusting the ratio, the anti-hair loss effect of the anti-hair loss essence can be optimized.

[0017] Preferably, the poloxamer is a polypeptide-modified poloxamer.

[0018] Through the above technical solution, while poloxamer itself has good biocompatibility, its physiological activity is insufficient, so sodium hyaluronate is needed to work synergistically to compensate for its physiological activity, enabling penetration and promoting absorption. However, after modification with peptides, peptides can penetrate the dermis, increase collagen, and reverse skin aging through internal-out reconstruction. Incorporating peptides into the molecular structure of poloxamer can impart certain physiological activity to the poloxamer, enabling a stronger synergistic effect with sodium hyaluronate, further promoting the scalp's absorption of nutrients.

[0019] Preferably, the preparation method of the polypeptide-modified poloxamer is as follows:

[0020] S1. reacting the polypeptide with thionyl chloride to obtain a polypeptide acyl chloride hydrochloride intermediate;

[0021] S2. reacting the poloxamer with the polypeptide acyl chloride hydrochloride intermediate to obtain the polypeptide-modified poloxamer.

[0022] By adopting the above technical solution, the yield of the target product can be improved by chlorinating the polypeptide and then reacting it with poloxamer.

[0023] Preferably, the polypeptide is palmitoyl pentapeptide-4.

[0024] By adopting the above technical solution, considering that the molecular structure of palmitoyl tripeptide-4 has a strong conjugation effect with the molecular structure of poloxamer, the molecular chain of the polypeptide is not suitable to fully exert its effect, and the effect of its polypeptide-modified poloxamer is not as good as palmitoyl pentapeptide-4.

[0025] Preferably, the average molecular weight of the poloxamer is 8350-11500.

[0026] By adopting the above technical solution, the molecular weight is too small and the ability to open pores is poor. When it is within this range, the effect is better.

[0027] Preferably, the preservative is prepared from the following raw materials in parts by weight: 85-95% phenoxyethanol and 5-15% ethylhexylglycerin.

[0028] In a second aspect, the present application provides a method for preparing an anti-hair loss essence lotion, which adopts the following technical solution:

[0029] A method for preparing an anti-hair loss essence, comprising the following steps:

[0030] S1. Weigh the raw materials of component B and component C according to the amount, and premix them to obtain a premixed solution of component B and a premixed solution of component C;

[0031] S2. Weigh all the raw materials of component A, stir and mix, and heat to 75-90°C, keep stirring until swollen and transparent;

[0032] S3. Stir and cool to 55-65°C, add the premixed solution of component B and stir evenly; then add the premixed solution of component C and stir evenly;

[0033] S4. Stir and cool to below 45°C, add the raw materials of components D and E, and stir evenly to obtain the anti-hair loss essence.

[0034] By adopting the above technical solution, the preparation method of the present application does not require special equipment or improvement of existing equipment, is highly tolerant to the parameters of the preparation process, is suitable for large-scale production in factories, and the products produced are highly uniform, have a high pass rate, and meet production standards.

[0035] In summary, this application includes at least one of the following beneficial technical effects:

[0036] 1. This application primarily aims to reduce hair loss by repairing hair follicles and soothing the scalp, thereby improving the health of the scalp and hair follicles. The simultaneous application of poloxamer and sodium hyaluronate in an anti-hair loss serum significantly enhances the serum's effectiveness. Sodium hyaluronate is a physiologically active substance widely found in animals and humans, distributed in human skin, synovial fluid, the umbilical cord, aqueous humor, and the vitreous humor. Its application in an anti-hair loss serum has been shown to significantly moisturize the scalp. Adding it together with poloxamer has also been shown to act as a penetrant and infusion solution. Furthermore, poloxamer itself possesses excellent biocompatibility, allowing it to be introduced into pores, opening and relaxing them, thereby promoting nutrient absorption. The moisturizing effect of sodium hyaluronate can moisturize the area surrounding the hair follicles, preventing nutrient loss and prolonging the duration of nutrient action, thereby improving scalp health.

[0037] 2. Although poloxamer itself has good biocompatibility, its physiological activity is insufficient, so sodium hyaluronate is needed to work synergistically to compensate for its physiological activity and promote penetration and absorption. However, after modification with peptides, peptides can penetrate the dermis, increase collagen, and reverse skin aging through internal and external reconstruction. Incorporating peptides into the molecular structure of poloxamer can impart certain physiological activity to poloxamer, enabling a stronger synergistic effect with sodium hyaluronate, further promoting the scalp's absorption of nutrients.

[0038] 3. Using the anti-hair loss essence prepared in this application for 28 days can effectively reduce the TEWL of the scalp by up to 4.59g / h / m 2 , scalp elasticity can be increased by up to 0.16, and hair loss can be significantly reduced after 12 weeks of use. DETAILED DESCRIPTION

[0039] The following is a further detailed description of this application in conjunction with the specific content.

[0040] raw material

[0041] The raw materials used in the preparation examples and embodiments of the present application can all be purchased commercially, among which the water used is deionized water; the water solubility of Platycladus orientalis leaf extract is fully water-soluble, with a specification of 10:1; the model of hydrogenated castor oil is PEG-40; the model of Polygonum multiflorum root extract is LZ-HSWTQW; the brand of sodium polyacryloyldimethyl taurate is Gulet; the effective substance content of betaine is 99%; niacinamide is food grade; the product number of tea extract is BJN0893; the grade of tetrahydropiperine is food grade; the content of matrine is 90%; the essence is rose essence, model A76454.

[0042] Preparation Example

[0043] Preparation Example 1

[0044] A polypeptide-modified poloxamer, the preparation method of which is as follows:

[0045] S1. Under anhydrous conditions, 47 g of a polypeptide, palmitoyl pentapeptide-4, was added to 50 g of DMF and stirred until dissolved. Under stirring, 8 g of thionyl chloride was added dropwise in an ice-water bath for half an hour. After the addition was complete, the mixture was heated to 50° C. and stirred for 2 hours. The mixture was then cooled to 20° C., 70 mL of anhydrous ether was added, stirred, filtered, washed with anhydrous ether, and dried at 50° C. to obtain a polypeptide chloride hydrochloride intermediate.

[0046] S2. Add 200 g of poloxamer and the polypeptide acyl chloride hydrochloride intermediate prepared in S1 to 200 g of DMF, stir until dissolved, then add 6 g of triethylamine dropwise, raise the temperature to 85° C., stir and react for 15 h, add 50 g of toluene, distill under reduced pressure to remove the solvent, then add 100 mL of anhydrous ether, stir for 10 min, filter, wash with anhydrous ether, and dry to obtain a polypeptide-modified poloxamer. The yield, calculated as the polypeptide, is 80.1%; wherein the average molecular weight of the poloxamer is 8350.

[0047] Preparation Example 2

[0048] A polypeptide-modified poloxamer is different from that in Preparation Example 1 in that the average molecular weight of the poloxamer is 11,500, and the remaining steps are the same as those in Preparation Example 1.

[0049] Preparation Example 3

[0050] A polypeptide-modified poloxamer is different from Preparation Example 1 in that its polypeptide is palmitoyl tripeptide-1, and the remaining steps are the same as Preparation Example 1.

[0051] Example

[0052] Example 1

[0053] An anti-hair loss essence lotion comprises component A, component B, component C, component D, and component E. The raw materials and the amounts of the raw materials are shown in Table 1. Component A comprises raw materials 1, 6, and 7; component B comprises raw materials 4, 8, and 10; component C comprises raw materials 2, 9, 11, and 12; component D comprises raw materials 3 and 5; and component E comprises raw material 13. The preparation method of the anti-hair loss essence lotion is as follows:

[0054] S1. Weigh the raw materials of each component according to the amount in Table 1. Prepare the premix of component B as follows: Take a clean container and stir the weighed raw materials of component B at room temperature until they are completely dissolved; prepare the premix of component C as follows: Take a clean container and stir the weighed raw materials of component C at room temperature until they are completely dissolved;

[0055] S2. Weigh the raw materials of component A according to the amount in Table 1 and add them to the production tank;

[0056] S3. Stir and heat to 85±2°C, keep warm and stir until the solution is completely swollen and transparent, at a speed of 30 r / min;

[0057] S4. Stir and cool to 60±2°C, add the premixed solution of component B into the production tank, stir evenly at a speed of 30r / min; add the premixed solution of component C into the production tank, stir evenly at a speed of 30r / min;

[0058] S5. Stir and cool to below 45°C, add the raw materials of components D and E into the production tank, stir evenly, and rotate at 30r / min;

[0059] S6. Discharging the semi-finished products. Semi-finished products are inspected and filled if qualified. Finished products are inspected and put into storage if qualified.

[0060] Among them, the average molecular weight of poloxamer is 8350.

[0061] Table 1 Raw materials and amounts of raw materials in Example 1

[0062]

[0063]

[0064] Example 2

[0065] An anti-hair loss essence lotion is different from Example 1 in that its poloxamer is a polypeptide-modified poloxamer, which is from Preparation Example 1, and the remaining steps are the same as Example 1.

[0066] Example 3

[0067] An anti-hair loss essence lotion is different from Example 1 in that its poloxamer is a polypeptide-modified poloxamer, which is from Preparation Example 2, and the remaining steps are the same as Example 1.

[0068] Example 4

[0069] An anti-hair loss essence lotion is different from Example 1 in that its poloxamer is a polypeptide-modified poloxamer, which is from Preparation Example 3, and the remaining steps are the same as Example 1.

[0070] Example 5

[0071] An anti-hair loss essence lotion is different from Example 2 in that the mass percentage of the polypeptide-modified poloxamer and sodium hyaluronate is 50:50, and the remaining steps are the same as Example 2.

[0072] Example 6

[0073] An anti-hair loss essence lotion is different from Example 2 in that the mass ratio of the polypeptide-modified poloxamer to sodium hyaluronate is 90:10, and the remaining steps are the same as Example 2.

[0074] Example 7

[0075] An anti-hair loss essence lotion is different from Example 2 in that the added amount of its E component, that is, raw material 13, is 0.01 kg, and the remaining steps are the same as Example 2.

[0076] Example 8

[0077] An anti-hair loss essence lotion is different from Example 2 in that the added amount of its E component, that is, raw material 13, is 0.1 kg, and the remaining steps are the same as Example 2.

[0078] Comparative Example

[0079] Comparative Example 1

[0080] An anti-hair loss essence lotion is different from Example 1 in that poloxamer is not added to its E component, and the remaining steps are the same as Example 1.

[0081] Comparative Example 2

[0082] An anti-hair loss essence lotion is different from Example 1 in that sodium hyaluronate is not added to its E component, and the remaining steps are the same as Example 1.

[0083] Comparative Example 3

[0084] An anti-hair loss essence lotion is different from Example 1 in that component E is not added to the anti-hair loss essence lotion, and the remaining steps are the same as those in Example 1.

[0085] Performance testing

[0086] Detection method / test method

[0087] Anti-hair loss essence lotions were prepared according to the preparation methods in Examples 1-8 and Comparative Examples 1-3, and then tested according to the following test method. The test results are shown in Tables 2 and 3.

[0088] Instructions for use of this anti-hair loss serum: After shampooing normally, the subject should apply 3-7 mL to the scalp and hair roots, depending on the amount of hair or hair habits, and massage for 5-10 minutes before rinsing.

[0089] Safety inspection:

[0090] Microbiological testing, physical and chemical testing, and toxicological testing: all conducted in accordance with the Technical Specifications for Safety of Cosmetics (2015 edition);

[0091] Human trials:

[0092] 1. Test subjects

[0093] Sixty volunteers aged 20-50 were randomly divided into 12 groups, with 5 people in each group. The volunteers had no obvious head diseases. One group served as the control group, which did not use any head care products except normal hair washing.

[0094] 2. Transepidermal Water Loss (TEWL) Test

[0095] The transepidermal water loss (TEWL) and skin moisture content data were measured using the German CK company's skin water loss tester Tewameter TM300 and the scalp water loss test probe Tewameter TM Nano; one test point was selected on the volunteer's head, and the position of the test point was recorded using a positioning film. The TEWL value before using the product of this application was measured and recorded as D0; the TEWL values ​​measured on the 14th and 28th days after continuous use were recorded as D14 and D28, respectively, and the average value of each group was then calculated; the greater the decrease in TEWL value, the better the skin barrier performance.

[0096] 3. Scalp elasticity difference

[0097] The scheme refers to T / CAB0152-2002 Cosmetic Anti-wrinkle, Firming, Moisturizing, Oil Control, Repairing, Nourishing, Soothing 7-item Efficacy Determination Method;

[0098] Scalp elasticity was measured using a Cutometer dualMPA580 skin elasticity tester from German CK Company. One test point was selected on the volunteer's head, and the location of the test point was recorded using a positioning film. The scalp elasticity values ​​were measured before using the product of this application and on the 28th day after continuous use. The average value for each group was calculated, and the scalp elasticity difference was then calculated, where a positive number indicates an increase in scalp elasticity, and a negative number indicates a decrease in scalp elasticity.

[0099] 4. Does it significantly reduce hair loss?

[0100] According to the specific requirements of Chapter 8, 6 of the "Technical Specifications for Safety of Cosmetics" (2015 edition) (Appendix 8 of the Announcement No. 17 of the State Food and Drug Administration in 2021), the hair loss count was performed after using the product of this application for 12 weeks. If the hair loss count at the 12th week is compared with the initial value, p<0.05, it indicates that hair loss is significantly reduced after 12 weeks of use.

[0101] Table 2 Safety test of Examples 1-8 and Comparative Examples 1-3

[0102]

[0103]

[0104] It can be seen from Table 2 that the anti-hair loss shampoos prepared in Examples 1-8 and Comparative Examples 1-3 of the present application all comply with the provisions of the "Technical Specification for Safety of Cosmetics" (2015 edition).

[0105] Table 3 Test results of Examples 1-8 and Comparative Examples 1-3

[0106]

[0107] It can be seen from the test data of Examples 1-8 and Comparative Examples 1-3, as well as Table 3, that the use of the anti-hair loss essence prepared by this application for 28 days can effectively reduce the TEWL of the scalp, which can be reduced by up to 4.59 g / h / m 2 , scalp elasticity can be increased by up to 0.16, and hair loss can be significantly reduced after 12 weeks of use.

[0108] This application is to alleviate the problem of hair loss by repairing hair follicles and soothing the scalp, and by improving the health level of the scalp and hair follicles. Poloxamer is a new type of high molecular non-ionic surfactant, which is a polyoxyethylene polyoxypropylene ether block polymer. It is commonly used as a pharmaceutical excipient for oral use. It can play the role of emulsification stabilization, solubilization, absorption promotion, sustained release, solid dispersant, etc. It is non-irritating to the skin and non-hemolytic. It is applied to anti-hair loss essence. Studies have found that it has excellent compatibility with the skin, can greatly improve the permeability of the skin, and promote the absorption of nutrients by the scalp, thereby repairing hair follicles, soothing the scalp, greatly improving the health level of the scalp, and playing an anti-hair loss role. This can be verified by the test data of Example 1 and Comparative Example 3.

[0109] The test data from Example 1 and Comparative Examples 1-3 show that poloxamer needs to be used in conjunction with sodium hyaluronate; adding it alone does not produce ideal results. Combined with the test data from Examples 5-6, the ratio of poloxamer to sodium hyaluronate is also a critical influencing factor. Sodium hyaluronate is a physiologically active substance widely found in animals and humans, distributed in human skin, synovial fluid, the umbilical cord, aqueous humor, and the vitreous humor. It is commonly used in cosmetics and has an excellent moisturizing effect. When used in an anti-hair loss serum, it was found to have an excellent moisturizing effect on the scalp. Adding it together with poloxamer revealed that sodium hyaluronate can act as a penetrant and infusion solution. Furthermore, poloxamer itself has good biocompatibility, allowing it to be introduced into the pores, opening and relaxing them, thereby promoting nutrient absorption. The moisturizing effect of sodium hyaluronate can moisturize the area around the hair follicles, preventing nutrient loss. The synergistic effect of these two substances greatly enhances the technical effectiveness of the anti-hair loss serum.

[0110] Although poloxamer itself has good biocompatibility, its physiological activity is insufficient, so sodium hyaluronate is needed to work in synergy to compensate for its physiological activity and to play a role in penetration and absorption. The test data of Example 1 and Example 2 show that the use of polypeptides can penetrate the dermis, increase collagen, and reverse the advantages of skin aging by reconstruction from the inside out. By modifying the polypeptide into the molecular structure of poloxamer, poloxamer can be given certain physiological activity, so that it can work more synergistically with sodium hyaluronate, further promoting the absorption of nutrients by the scalp. In the case where Chinese herbal extracts do not need to be added in large quantities and in a variety of ways, the improvement in scalp health is significant, and the anti-hair loss effect is excellent. The volunteers of the product of the present application all give positive reviews. In conjunction with Examples 3-4, the average molecular weight of poloxamer should not be too large. And the effect of the polypeptide being palmitoyl pentapeptide-4 is better. Considering the molecular structure in palmitoyl tripeptide-1, the conjugation effect with the molecular structure of poloxamer is stronger, and the molecular chain of the polypeptide should not give full play to its effect.

[0111] It can be seen from the test data of Example 1 and Examples 7-8 that as the amount of added skin penetrant gradually increases, the effect of improving the scalp shows an upward trend, but after the addition amount increases from 0.05 kg to 0.1 kg, the upward trend of the effect is small. Therefore, considering the comprehensive cost, 0.05 kg is the optimal addition amount.

[0112] This specific embodiment is merely an explanation of the present invention and is not intended to limit the present invention. After reading this specification, those skilled in the art may make non-creative modifications to this embodiment as needed. However, as long as such modifications are within the scope of the claims of the present invention, they are protected by patent law.

Claims

1. An anti-hair loss essence, characterized by: The anti-hair loss essence comprises component A, component B, component C, component D and component E. The total weight percentage of the raw materials in each component is 100%, and the weight percentage of each component added is as follows: Component A: thickener 0.4-0.6%, moisturizer 0.3-0.7%, solvent added to 100% by weight of the anti-hair loss essence, the solvent is water; Component B: skin protectant (1) 1.5-3.5%, niacinamide 0.3-0.7%, skin protectant (2) 0.08-0.12%; The skin protectant (1) is prepared from the following raw materials in percentage by weight: 3-7% of Polygonum multiflorum root extract, 2-4% of propylene glycol, 0.4-0.8% of 1,2-hexanediol, 0.4-0.7% of phenoxyethanol, 0.04-0.08% of ethylhexylglycerin, and water is added to make up 100% of the weight of the skin protectant (1); The skin protectant (2) is prepared from the following raw materials in percentage by weight: 10-20% glycerin, 1-4% tea extract, 0.4-0.8% 1,2-hexanediol, 0.3-0.7% phenoxyethanol, 0.04-0.08% ethylhexylglycerin, and water is added to make up to 100% of the weight of the skin protectant (2); Component C: solvent 35-45%, fragrance 0.1-0.3%, tetrahydropiperine 0.03-0.07%, matrine 0.005-0.015%; Component D: anti-hair loss agent 4-6%, preservative 0.3-1.0%; The anti-hair loss agent is prepared from the following raw materials in percentage by weight: 15-21% 1,3-propylene glycol, 15-21% orientalis leaf extract, 0.4-0.8% hydrogenated castor oil, 0.08-0.12% disodium EDTA, and water is added to 100% of the weight of the anti-hair loss agent; Component E: 0.01-0.1% skin penetrant; the skin penetrant is made from the following raw materials in percentage by weight: 50-90% polypeptide-modified poloxamer, 10-50% sodium hyaluronate; The preparation method of the polypeptide-modified poloxamer is as follows: S1. reacting the polypeptide with thionyl chloride to obtain a polypeptide acyl chloride hydrochloride intermediate; S2, reacting the poloxamer with the polypeptide acyl chloride hydrochloride intermediate to obtain the polypeptide-modified poloxamer; The polypeptide is palmitoyl pentapeptide-4; The average molecular weight of the poloxamer is 8350-11500.

2. The anti-hair loss essence according to claim 1, characterized in that: The skin penetrant is prepared from the following raw materials in percentage by weight: 70% of polypeptide-modified poloxamer and 30% of sodium hyaluronate.

3. The anti-hair loss essence according to claim 1, characterized in that: The preservative is prepared from the following raw materials in percentage by weight: 85-95% phenoxyethanol and 5-15% ethylhexylglycerin.

4. A method for preparing the anti-hair loss essence according to any one of claims 1 to 3, characterized in that: It includes the following steps: S1. Weigh the raw materials of component B and component C according to the amount, and premix them to obtain a premixed solution of component B and a premixed solution of component C; S2. Weigh all the raw materials of component A, stir and mix, and heat to 75-90°C, keep stirring until swollen and transparent; S3. Stir and cool to 55-65°C, add the premixed solution of component B and stir evenly; then add the premixed solution of component C and stir evenly; S4. Stir and cool to below 45°C, add the raw materials of components D and E, and stir evenly to obtain the anti-hair loss essence.

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