Anti-hair loss and solidifying composition, preparation method and application thereof

Abstract

The present invention discloses an anti-hair loss and solidifying composition, a preparation method and application thereof. The composition comprises the following components in parts by weight: 10-20 parts of Lychnophora sylvestris extract, 10-20 parts of Ginkgo biloba extract, 10-30 parts of Poria cocos extract, 8-16 parts of Platycladus orientalis leaf extract, 7-12 parts of Angelica sinensis extract, 7-12 parts of Polygonum multiflorum extract, 5-10 parts of peppermint extract, 1-15 parts of squalane, 0.3-5 parts of adenosine, 20-70 parts of butylene glycol and 30-250 parts of water. The anti-hair loss and solidifying composition provided by the present invention can stimulate hair follicles, promote hair growth, improve hair quality, and reduce hair loss, and has good application prospects in hair products.

Description

Technical Field

[0001] The present invention relates to the technical field of daily cosmetics, and in particular to an anti-hair loss and hair solidifying composition, a preparation method and an application thereof. Background Art

[0002] Influenced by genetics, inflammation, and environmental factors, hair loss is difficult to completely eradicate and has become a problem that plagues many consumers. Furthermore, hair loss is no longer limited to the elderly; it now affects younger people, becoming a major health concern for both physical and mental health.

[0003] Hair loss is divided into physiological and pathological types. Pathological types include alopecia areata, psychogenic, endocrine-induced, and seborrheic. Currently, a large number of hair loss prevention and hair growth products are available on the market, but most have been found to have limited effectiveness and fail to completely address the issue of hair loss, or even lead to other hair problems. Marketed products have poor raw material formula stability, resulting in poor effectiveness, or have unreasonable or irritating formulas that can cause scalp allergies, itching, oily hair, dandruff, and other issues. Of course, there are also products that use safer, pure Chinese herbal formula ingredients, but these ingredients can be ineffective or slow to take effect.

[0004] Therefore, it is necessary to develop anti-hair loss and hair strengthening products that are more effective, gentler and safer to meet the needs of people with hair loss. Summary of the Invention

[0005] The purpose of the present invention is to provide an anti-hair loss and hair solidification composition, a preparation method and application thereof, which has excellent effects of promoting hair growth from hair follicles and improving hair quality, can strengthen and toughen hair, and significantly reduce the frequency of hair loss and hair shedding.

[0006] To this end, the present invention adopts the following technical solutions:

[0007] The invention provides an anti-hair loss and solidifying composition, comprising the following components in parts by weight: 10-20 parts of Lychnophora sylvestris extract, 10-20 parts of Ginkgo biloba extract, 10-30 parts of Poria cocos extract, 8-16 parts of Platycladus orientalis leaf extract, 7-12 parts of Angelica sinensis extract, 7-12 parts of Polygonum multiflorum extract, 5-10 parts of peppermint extract, 1-15 parts of squalane, 0.3-5 parts of adenosine, 20-70 parts of butylene glycol and 30-150 parts of water.

[0008] Preferably, the invention further comprises 10-20 parts of Atractylodes lancea rhizome extract and / or 10-20 parts of Campanula variegata bark extract.

[0009] Preferably, it further comprises 1-7 parts of Rosa canina fruit oil and / or 1-7 parts of Verbena oil.

[0010] Preferably, it further contains 0.1-1.5 parts of dihydrosphingosine.

[0011] Furthermore, the preparation method of the Lychnophora camphora extract comprises the following steps:

[0012] (1) crushing the dried Lychnophora scabra through a 30-80 mesh filter to obtain Lychnophora scabra powder;

[0013] (2) immersing the Lychnophora sylvestris powder obtained in step (1) in ethanol, sonicating for 0.5-1 h, and separating the filtrate and the residue;

[0014] (3) dissolving the filter residue obtained in step (2) in an ethanol solution having a mass fraction of 0-10%, heating in a water bath and refluxing for a period of time, separating the filtrate and the filter residue to obtain extract 1;

[0015] (4) dissolving the filter residue obtained in step (3) in an ethanol solution having a mass fraction of 15-30%, heating under reflux in a water bath for a period of time, separating the filtrate and the filter residue to obtain extract 2;

[0016] (5) dissolving the filter residue obtained in step (4) in an ethanol solution having a mass fraction of 35-50%, heating under reflux in a water bath for a period of time, separating the filtrate and the filter residue to obtain extract 3;

[0017] (6) The filtrate, extract 1, extract 2, and extract 3 obtained in step (2) are combined, and the combined solution is concentrated to 1 / 3 to 1 / 4 of the original volume, and dried to obtain a Lychnophora sylvestris extract.

[0018] Preferably, in step (3), the heating temperature is 75-95°C, and the extraction time is 1-3h; and / or, in step (4), the heating temperature is 70-90°C, and the extraction time is 1-3h; and / or, in step (5), the heating temperature is 70-90°C, and the extraction time is 1-3h.

[0019] The present invention also provides a method for preparing the anti-hair loss and hair solidifying composition, comprising the following steps: weighing various raw materials according to a proportion, and mixing and stirring the various components uniformly to obtain the composition.

[0020] The present invention further provides an application of the anti-hair loss and hair solidifying composition in hair products.

[0021] Preferably, the amount of the anti-hair loss and hair solidifying composition added to the hair product is 5-30 wt%.

[0022] Preferably, the hair products include shampoo, hair conditioner, shampoo cream, essence

[0023] Compared with the prior art, the present invention has the following beneficial effects:

[0024] The anti-hair loss and hair strengthening composition of the present invention adopts a scientific ratio of Lycopodiella vulgaris extract, Ginkgo biloba extract, Poria cocos extract, Platycladus orientalis leaf extract, Angelica sinensis extract, Polygonum multiflorum extract, peppermint extract, Atractylodes lancea rhizome extract, Campanula variegata bark extract, squalane and adenosine, and has excellent effects of promoting hair follicle growth, reducing hair loss and strengthening hair roots.

[0025] The anti-hair loss and strengthening composition of the present invention can promote blood circulation in the scalp, increase nutrition for hair follicles, promote hair growth, enhance hair elasticity and toughness, and prevent hair breakage and loss. Extracts from Lychnophora sibiricum, Campanula variegata bark, and Atractylodes macrocephala rhizome work together to effectively regulate the scalp microenvironment, improving essential issues such as oiliness, clogged hair follicles, and bacterial growth, while enhancing the scalp's ability to absorb nutrients. Further combined with active plant extracts such as Ginkgo biloba extract, Poria cocos extract, Platycladus orientalis leaf extract, Angelica sinensis extract, Polygonum multiflorum extract, and Peppermint extract, the composition provides the hair with rich nutrients, improving hair growth, repairing damaged hair, thickening and strengthening hair, and preventing breakage and hair loss.

[0026] The Lychnophora camphora extract provided by the present invention is extracted by alcohol, and the filter residue is extracted sequentially from low to high alcohol concentrations to obtain a higher content of active ingredients that effectively promote hair growth and hair fixation. When combined with other ingredients in the composition of the present invention, it can act synergistically to more significantly stimulate hair follicle production, improve hair quality, enhance hair toughness, and significantly reduce the extent of hair loss.

[0027] The anti-hair loss and solidifying composition of the present invention is mild and non-irritating, has obvious effects, and has good application prospects in hair care and growth products. DETAILED DESCRIPTION

[0028] Below by specific embodiment, the specific embodiment of this explanation technical scheme is further described, and these embodiments are for the detailed description of this technical scheme, rather than for limiting this technical scheme. Based on the embodiment in this explanation, the every other embodiment that those of ordinary skill in the art obtain without making creative work premise all fall within the scope of this explanation protection. Unless otherwise specified, the reagent, method and equipment adopted in the present invention are conventional reagents, methods and equipment in the art, and the reagents and materials used in the following examples are all commercially available.

[0029] Preparation Example 1

[0030] This preparation example provides a method for preparing a Lychnophora camphora extract, comprising the following steps:

[0031] (1) Grinding the dried Lychnos chinensis through a 60-mesh filter to obtain Lychnos chinensis powder;

[0032] (2) immersing the Lychnophora powder obtained in step (1) in ethanol, ultrasonicating for 1 h, and separating the filtrate and the residue;

[0033] (3) The filter residue obtained in step (2) was dissolved in a 5% by mass ethanol solution, and the mixture was heated in a water bath under reflux for 2 h at a heating temperature of 85° C. The filtrate and the filter residue were separated to obtain extract 1;

[0034] (4) dissolving the filter residue obtained in step (3) in an ethanol solution having a mass fraction of 20%, heating the mixture under reflux in a water bath for 1.5 h at a heating temperature of 85° C., separating the filtrate and the filter residue to obtain extract 2;

[0035] (5) dissolving the filter residue obtained in step (4) in a 50% ethanol solution, heating under reflux in a water bath for 1 h at a heating temperature of 85° C., separating the filtrate and the filter residue to obtain extract 3;

[0036] (6) The filtrate, extract 1, extract 2, and extract 3 obtained in step (2) were combined, the combined solution was concentrated to 1 / 4 of the original volume, and dried to obtain Lychnophora camphora extract A.

[0037] Preparation Example 2

[0038] This preparation example provides a method for preparing a Lychnophora camphora extract, comprising the following steps:

[0039] (1) Grinding the dried Lychnos chinensis through a 60-mesh filter to obtain Lychnos chinensis powder;

[0040] (2) immersing the Lychnophora powder obtained in step (1) in ethanol, ultrasonicating for 1 h, and separating the filtrate and the residue;

[0041] (3) dissolving the filter residue obtained in step (2) in water, heating under reflux in a water bath for 2 h at a heating temperature of 90° C., separating the filtrate and the filter residue to obtain extract 1;

[0042] (4) dissolving the filter residue obtained in step (3) in an ethanol solution having a mass fraction of 20%, heating the mixture under reflux in a water bath for 1.5 h at a heating temperature of 85° C., separating the filtrate and the filter residue to obtain extract 2;

[0043] (5) dissolving the filter residue obtained in step (4) in a 50% ethanol solution, heating under reflux in a water bath for 1 h at a heating temperature of 85° C., separating the filtrate and the filter residue to obtain extract 3;

[0044] (6) The filtrate, extract 1, extract 2, and extract 3 obtained in step (2) were combined, and the combined solution was concentrated to 1 / 4 of the original volume, and dried to obtain Lycopodiella vulgaris extract B.

[0045] Example 1

[0046] A hair loss prevention and solidifying composition comprises the following components in parts by weight: 15 parts of Lychnophora arborvitae extract A, 10 parts of Ginkgo biloba extract, 15 parts of Poria cocos extract, 10 parts of Platycladus orientalis leaf extract, 8 parts of Angelica sinensis extract, 10 parts of Polygonum multiflorum extract, 7 parts of peppermint extract, 13 parts of Atractylodes lancea rhizome extract, 13 parts of Campanula variegata bark extract, 5 parts of squalane, 1 part of adenosine, 20 parts of butylene glycol and 180 parts of water.

[0047] Example 2

[0048] A hair loss prevention and solidifying composition comprises the following components in parts by weight: 15 parts of Lychnophora arborvitae extract B, 10 parts of Ginkgo biloba extract, 15 parts of Poria cocos extract, 15 parts of Platycladus orientalis leaf extract, 10 parts of Angelica sinensis extract, 12 parts of Polygonum multiflorum extract, 9 parts of peppermint extract, 15 parts of Atractylodes lancea rhizome extract, 13 parts of Campanula variegata bark extract, 5 parts of squalane, 1 part of adenosine, 30 parts of butylene glycol and 200 parts of water.

[0049] Example 3

[0050] A hair loss prevention and solidifying composition comprises the following components in parts by weight: 20 parts of Lychnophora arborvitae extract B, 10 parts of Ginkgo biloba extract, 20 parts of Poria cocos extract, 15 parts of Platycladus orientalis leaf extract, 10 parts of Angelica sinensis extract, 12 parts of Polygonum multiflorum extract, 9 parts of peppermint extract, 10 parts of Atractylodes lancea rhizome extract, 15 parts of Campanula variegata bark extract, 10 parts of squalane, 5 parts of adenosine, 50 parts of butylene glycol and 200 parts of water.

[0051] Example 4

[0052] A hair loss prevention and solidifying composition comprises the following components in parts by weight: 10 parts of Lychnophora arborvitae extract B, 15 parts of Ginkgo biloba extract, 15 parts of Poria cocos extract, 15 parts of Platycladus orientalis leaf extract, 10 parts of Angelica sinensis extract, 12 parts of Polygonum multiflorum extract, 9 parts of peppermint extract, 10 parts of Atractylodes lancea rhizome extract, 10 parts of Campanula variegata bark extract, 3 parts of squalane, 5 parts of adenosine, 35 parts of butylene glycol and 200 parts of water.

[0053] Example 5

[0054] A hair loss prevention and solidifying composition comprises the following components in parts by weight: 20 parts of Lychnophora arborvitae extract A, 20 parts of Ginkgo biloba extract, 15 parts of Poria cocos extract, 12 parts of Platycladus orientalis leaf extract, 8 parts of Angelica sinensis extract, 12 parts of Polygonum multiflorum extract, 7 parts of peppermint extract, 15 parts of Atractylodes lancea rhizome extract, 15 parts of Campanula variegata bark extract, 10 parts of squalane, 2 parts of adenosine, 50 parts of butylene glycol and 200 parts of water.

[0055] Example 6

[0056] A hair loss prevention and solidifying composition comprises the following components in parts by weight: 20 parts of Lychnophora arborvitae extract B, 10 parts of Ginkgo biloba extract, 20 parts of Poria cocos extract, 15 parts of Platycladus orientalis leaf extract, 10 parts of Angelica sinensis extract, 12 parts of Polygonum multiflorum extract, 9 parts of peppermint extract, 10 parts of Atractylodes lancea rhizome extract, 15 parts of Campanula variegata bark extract, 10 parts of squalane, 5 parts of adenosine, 5 parts of Rosa canina fruit oil, 3 parts of Verbena oil, 50 parts of butylene glycol and 192 parts of water.

[0057] Example 7

[0058] A hair loss prevention and solidifying composition comprises the following components in parts by weight: 20 parts of Lychnophora arborvitae extract B, 10 parts of Ginkgo biloba extract, 20 parts of Poria cocos extract, 15 parts of Platycladus orientalis leaf extract, 10 parts of Angelica sinensis extract, 12 parts of Polygonum multiflorum extract, 9 parts of peppermint extract, 10 parts of Atractylodes lancea rhizome extract, 15 parts of Campanula variegata bark extract, 10 parts of squalane, 5 parts of adenosine, 5 parts of Rosa canina fruit oil, 3 parts of Verbena oil, 0.5 parts of dihydrosphingosine, 50 parts of butylene glycol and 191.5 parts of water.

[0059] Comparative Example 1

[0060] Compared with Example 3, the difference is that no Lychnophora extract is added, and the other aspects are the same.

[0061] Comparative Example 2

[0062] Compared with Example 3, the difference is that the Lychnophora sylvestris extract and the Atractylodes lancea rhizome extract are not added, and the other parts are the same.

[0063] Comparative Example 3

[0064] Compared with Example 3, the difference is that the Lychnophora arvense extract and the Campanula variegata bark extract are not added, and the other aspects are the same.

[0065] Comparative Example 4

[0066] Compared with Example 3, the difference is that: the Lychnophora arboricola extract, the Atractylodes lancea rhizome extract, and the Campanula variegata bark extract are not added, and the other parts are the same.

[0067] Comparative Example 5

[0068] Compared with Example 3, the difference is that the Lychnophora sylvestris extract and the Platycladus orientalis leaf extract are not added, and the other aspects are the same.

[0069] Comparative Example 6

[0070] Compared with Example 3, the difference is that: no Lychnophora sylvestris extract, Platycladus orientalis leaf extract, and Polygonum multiflorum extract are added, and the other aspects are the same.

[0071] Comparative Example 7

[0072] Compared with Example 3, the difference is that: no Lychnophora sylvestris extract, Platycladus orientalis leaf extract, Polygonum multiflorum extract, and Poria cocos extract are added, and the other parts are the same.

[0073] Comparative Example 8

[0074] Compared with Example 3, the difference is that the preparation method of the Lychnophora quinquefolia extract is different, and the other aspects are the same.

[0075] The preparation method of Lychnophora quinquefolia extract is as follows: dissolve Lychnophora quinquefolia powder in 8 times the volume of water, perform extraction under reflux in a water bath at 80° C. for 3 h, concentrate, and dry to obtain the extract.

[0076] Comparative Example 9

[0077] Compared with Example 3, the difference is that the preparation method of the Lychnophora quinquefolia extract is different, and the other aspects are the same.

[0078] The preparation method of Lychnophora quinquefolia extract is as follows: dissolve Lychnophora quinquefolia powder in 8 times the volume of 90% ethanol by mass, extract under reflux in a water bath at 80° C. for 3 h, concentrate, and dry to obtain the extract.

[0079] The preparation method of the anti-hair loss and hair solidifying composition of Examples 1-7 and Comparative Examples 1-9 is as follows: weigh the raw materials according to the proportions, mix the components and stir them until uniformly mixed, to obtain the compositions.

[0080] Application Examples

[0081] Disclosed is an anti-hair loss and hair strengthening essence, comprising 10% of an anti-hair loss and hair strengthening composition, 5% of propylene glycol, 0.3% of PEG-40 hydrogenated castor oil, 0.5% of phenoxyethanol and the balance of water.

[0082] The anti-hair loss and hair solidifying composition is selected from the compositions of Examples 1-7 and Comparative Examples 1-9.

[0083] In order to verify the anti-hair loss and hair strengthening effect of the composition of the present invention, the following tests were performed:

[0084] (1) Safety testing

[0085] The compositions prepared in all the above examples and comparative examples were subjected to human safety patch tests. The test method was based on the human skin patch test in the "2015 Cosmetic Safety Technical Specifications". The method of the skin occlusion patch test was as follows: 80 people aged 30-55 years were selected, 5 in each group, and the area of the patch was no more than 50 mm. 2A qualified spot test device with a depth of approximately 1 mm was used. 0.020 mL of the composition prepared in the above examples and comparative examples was placed into the spot test chamber. The control well served as a blank control (no substance was placed). The spot test device containing the anti-hair loss and hair strengthening composition was applied to the curved side of the subject's forearm using hypoallergenic tape. The spot test device was gently pressed with the palm of the hand to ensure even adhesion to the skin for 24 hours. Skin reactions were observed according to the criteria in Table 1 30 minutes after removing the spot test device (after the indentation disappeared), 24 hours, and 48 hours afterward, and the results were recorded.

[0086] Table 1 Observation criteria

[0087]

[0088]

[0089] The experimental results showed no positive reactions, and all the compositions prepared in the examples and comparative examples passed the human patch safety test, indicating that the anti-hair loss and hair solidifying composition of the present invention is safe and has no adverse reactions.

[0090] (2) Efficacy test

[0091] 1. Mouse Hair Growth Test

[0092] 180 Wistar rats, half male and half female, with similar weight and hair growth, were taken and divided into 170 modeling groups and 10 blank controls. A 3cm×3cm area was selected from the same position on the back of the rats and dyed yellow with 3% picric acid solution as the test area. Except for the control group, the mice in the other groups were subcutaneously injected with testosterone propionate (1mg / kg"d dose) at the back of the neck once a day for 60 consecutive days to make models, and then depilated to mark the test area. The mice after modeling were randomly divided into 17 groups, 10 in each group, corresponding to Examples 1-7 and Comparative Examples 1-9, and the minoxidil group, and then the anti-hair loss and hair-fixing compositions prepared by Examples 1-7 and Comparative Examples 1-9 and 2% minoxidil solution were applied to the test area every day, and each sample was applied with 2mL each time. Changes in the skin on the back of the mice and hair growth were observed daily. The blank group was not treated after depilation. After 30 days, 10 longer hairs were randomly selected from the test area for each group of experimental mice, and their lengths were measured using a vernier caliper. The hair in the test area was collected and weighed at the same time. The test results were statistically analyzed and the average value was taken. The hair in the test area of the mice was observed to see if it was sparse or messy. The test results are shown in Table 2.

[0093] Table 2 Effects of the composition on hair growth in mice

[0094]

[0095]

[0096] As shown in Table 2, compared with the control group, the minoxidil group, and the blank group, the rats in Examples 1-7 of the present invention had longer, thicker hair, smoother hair, and a higher glossiness. This indicates that the hair loss prevention and strengthening composition provided by the present invention has a more significant effect in promoting hair growth in rats.

[0097] Compared with Example 3, Comparative Example 1 did not add the Lychnophora sylvestris extract, and the average hair length and average hair weight were lower, and the glossiness was lighter.

[0098] Compared with Example 3, Comparative Example 2 did not add the Lychnophora arborvitae extract and the Atractylodes lancea rhizome extract, and the average hair length and average hair weight were lower, the glossiness was lighter, and was slightly worse than Comparative Example 1.

[0099] Compared with Example 3, Comparative Example 3 did not add the Lychnophora arvense extract and the Campanula variegata bark extract, and the average hair length and average hair weight were lower, the glossiness was lighter, and was slightly worse than Comparative Example 1.

[0100] Compared with Example 3, Comparative Example 4 did not add the Lychnophora arborescens extract, the Atractylodes lancea rhizome extract, and the Campanula variegata bark extract. The average hair length and average hair weight were lower, the hair gloss was significantly worse than that of Comparative Example 1, indicating that the simultaneous addition of the Lychnophora arborescens extract, the Atractylodes lancea rhizome extract, and the Campanula variegata bark extract can act synergistically to improve hair growth, and the lack of any one of them will reduce the effect of promoting hair growth.

[0101] Compared with Example 3, Comparative Example 5 did not add the Lychnophora arborvitae extract and the Platycladus orientalis leaf extract, and the average hair length and average hair weight were lower, the glossiness was lighter, and was slightly worse than Comparative Example 1.

[0102] Compared with Example 3, Comparative Example 6 did not add the Lychnophora arborvitae extract, Platycladus orientalis leaf extract, and Polygonum multiflorum extract, and the average hair length and average hair weight were lower, the glossiness was lighter, and it was slightly worse than Comparative Example 5.

[0103] Compared with Example 3, Comparative Example 7 did not add Lychnophora cucullata extract, Platycladus orientalis leaf extract, Polygonum multiflorum extract, and Poria cocos extract. The average hair length and average hair weight were both lower, the hair was dull, and was significantly worse than that of Comparative Example 6, indicating that the simultaneous presence of Lychnophora cucullata extract, Platycladus orientalis leaf extract, Polygonum multiflorum extract, and Poria cocos extract can work together to better promote hair growth.

[0104] Compared with Example 3, the preparation methods of the Lychnophora extracts in Comparative Examples 8 and 9 are different, and the average hair length and average hair weight are both lower, and the glossiness is lighter, indicating that the preparation method of the Lychnophora extract provided by the present invention, and the active ingredients obtained have a more significant effect of promoting hair growth.

[0105] 2. Anti-hair loss efficacy test

[0106] (1) Selection of subjects

[0107] Eligible subjects were selected according to the inclusion and exclusion criteria, and divided into experimental and control groups according to the random table to ensure that the final number of effective cases was no less than 20 people / group.

[0108] Inclusion criteria: Healthy men or women aged 25 to 50 years. Subjects were stratified by age and randomly assigned to experimental and control groups. Hair length was between 5 and 40 cm. Subjects had severe hair loss or mild hair thinning, with a hair count of more than 10 strands after 60 combing strokes and still more than 10 strands after a 2-week washout period. Subjects had not undergone any special hair treatments, such as dyeing, perming, or styling, within the past month. Subjects were able to understand the experimental procedures, voluntarily participated in the trial, and signed a written informed consent form.

[0109] Exclusion criteria: pregnant or breastfeeding women, or those who are planning to get pregnant in the near future; patients with severe androgenic alopecia, alopecia areata, inflammatory cicatricial alopecia or other scalp / hair diseases; patients with psychiatric or psychological diseases; or patients with long-term sleep or mood control disorders; those who have used cosmetics with anti-hair loss effects or other products with such effects or hair growth effects in the past 3 months; those who have taken or topically applied any medication that affects hair growth in the past 6 months; those who have received hair transplant treatment; those with curly hair; those with highly sensitive constitutions; those who have participated in other clinical trials in the past 2 months; those who are deemed unsuitable for participation in the trial by clinical assessment.

[0110] Subject restrictions: Subjects are not allowed to comb their own hair on the day of the visit; no haircut is allowed within 2 weeks before each visit assessment during the trial; no hair care or hairstyling measures are allowed during the trial, and no hair loss prevention or hair growth treatments are allowed; the original lifestyle habits must be maintained during the trial to avoid large mood swings.

[0111] (2) Test method: 320 subjects were selected, including 200 males and 120 females. After the subjects were stratified by age, subjects of the same age group were randomly divided into experimental and control groups, totaling 17 groups. The sample (including the anti-hair loss and strengthening essence of the Example or Comparative Example) was applied to the hair loss area of the scalp after washing, with about 5g applied each time, 3 times a week, and each test substance was used for at least 8 weeks.

[0112] (3) Hair loss count: During each visit, the subjects' hair was combed 60 times, the number of hairs lost was counted, and the average value for each group was taken and recorded in Table 3; the calculation method for the change range was: hair loss reduction rate = (number of hairs lost before use - number of hairs lost after use) / number of hairs lost before use * 100%.

[0113] Table 3 Improvement of hair loss by anti-hair loss essence

[0114]

[0115]

[0116] As can be seen from Table 3, the anti-hair loss and hair-fixing composition obtained using the technical solution of the present invention has an excellent effect in preventing hair loss. After 8 weeks of use, the number of lost hairs decreased by 45-57.14% compared to the number of lost hairs before use. This is significantly higher than the 23.53-43.75% decrease in the number of lost hairs in Comparative Examples 1-7.

[0117] Therefore, the anti-hair loss and hair solidifying composition provided by the present invention has the functions of promoting hair growth, strengthening hair roots, and reducing hair loss, and has a good application prospect in preventing hair loss and hair solidifying.

[0118] Although the embodiments of the present disclosure have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and alterations may be made to the embodiments without departing from the principles and spirit of the present disclosure, the scope of which is defined by the appended claims and their equivalents.

Claims

1. An anti-hair loss and hair solidifying composition, characterized in that: The invention comprises the following components in parts by weight: 10-20 parts of Lychnophora japonica extract, 10-20 parts of Ginkgo biloba extract, 10-30 parts of Poria cocos extract, 8-16 parts of Platycladus orientalis leaf extract, 7-12 parts of Angelica sinensis extract, 7-12 parts of Polygonum multiflorum extract, 5-10 parts of Mentha arvensis extract, 1-15 parts of Squalane, 0.3-5 parts of Adenosine, 20-70 parts of Butanediol and 30-250 parts of Water, and further comprises 10-20 parts of Atractylodes macrocephala rhizome extract and 10-20 parts of Campanula variegata bark extract; the preparation method of the Lychnophora japonica extract comprises the following steps: (1) crushing the dried Lychnophora japonica and filtering through 30-80 mesh to obtain Lychnophora japonica powder; (2) immersing the Lychnophora japonica powder obtained in step (1) in ethanol, ultrasonicating for 0.5-1h, and separating the filtrate. and filter residue; (3) dissolving the filter residue obtained in step (2) with an ethanol solution having a mass fraction of 0-10%, heating and reflux extraction in a water bath for a period of time, separating the filtrate and the filter residue to obtain extract 1; (4) dissolving the filter residue obtained in step (3) with an ethanol solution having a mass fraction of 15-30%, heating and reflux extraction in a water bath for a period of time, separating the filtrate and the filter residue to obtain extract 2; (5) dissolving the filter residue obtained in step (4) with an ethanol solution having a mass fraction of 35-50%, heating and reflux extraction in a water bath for a period of time, separating the filtrate and the filter residue to obtain extract 3; (6) combining the filtrate, extract 1, extract 2 and extract 3 obtained in step (2), concentrating the combined solution to 1 / 3 to 1 / 4 of the original volume, and drying to obtain a Herba Lysimachiae extract.

2. The anti-hair loss and solidifying composition according to claim 1, characterized in that The invention further comprises 1-7 parts of dog rose fruit oil and / or 1-7 parts of verbena oil.

3. The anti-hair loss and solidifying composition according to claim 2, characterized in that: It also contains 0.1-1.5 parts of dihydrosphingosine.

4. The anti-hair loss and solidifying composition according to claim 1, characterized in that In step (3), the heating temperature is 75-95° C., and the extraction time is 1-3 hours.

5. The anti-hair loss and solidifying composition according to claim 1, characterized in that In step (4), the heating temperature is 70-90° C., and the extraction time is 1-3 hours.

6. The anti-hair loss and solidifying composition according to claim 1, characterized in that In step (5), the heating temperature is 70-90° C., and the extraction time is 1-3 hours.

7. The method for preparing the anti-hair loss and hair solidifying composition according to any one of claims 1 to 6, characterized in that: The method comprises the following steps: weighing various raw materials according to a proportion, and mixing and stirring the various components evenly to obtain the product.

8. Use of the anti-hair loss and solidifying composition according to any one of claims 1 to 6 in the preparation of hair products.

9. The use according to claim 8, characterized in that The amount of the anti-hair loss and hair solidifying composition added to hair products is 5-30 wt%.

10. The use according to claim 8, characterized in that The hair products include shampoo, hair conditioner, shampoo cream and essence.

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