Traditional Chinese medicine composition, ointment and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition, ointment and application thereof. The traditional Chinese medicine composition contains radix pseudostellariae, Chinese yam, poria cocos, angelica sinensis, liquorice, lily, lotus seeds, rice-grain sprouts, hawthorn, bighead atractylodes rhizome, galangal, cassia twigs, radix paeoniae alba, paederia scandens, curcuma zedoary and hyacinth bean flowers, and is obtained based on long-time summarization and continuous compatibility adjustment. Ointment prepared from the traditional Chinese medicine composition can effectively treat infantile anorexia, infantile tourette syndrome and dwarf syndrome caused by spleen deficiency, and the traditional Chinese medicine composition can be used for preparing medicines for treating infantile anorexia, dwarf syndrome, infantile tourette syndrome and the like caused by spleen deficiency. In addition, the traditional Chinese medicine composition is prepared into traditional Chinese medicine ointment, has the advantages of being high in medicine content, good in taste, convenient to take, easy to accept and the like, and is beneficial to treatment of diseases caused by spleen deficiency.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and more specifically, relates to a traditional Chinese medicine composition, an ointment and application thereof. Background Art

[0002] Spleen deficiency is an important part of the spleen zang-fu theory in traditional Chinese medicine. It refers to weak spleen function, which is mainly manifested in the decline of food digestion and nutrient absorption function, reduced material metabolism and energy conversion ability, and immune and endocrine disorders. It is a comprehensive syndrome reflecting the deficiency of various physiological functions of "spleen is responsible for transportation and transformation, ascending the clear, and regulating blood".

[0003] Spleen deficiency includes spleen deficiency, spleen yang deficiency, spleen yin deficiency and other types, which are mainly caused by multiple factors such as diet, lifestyle, mental state, and disease, leading to spleen yin and yang, qi and blood deficiency and dysfunction. Spleen deficiency is a common clinical disease. Patients with long-term illness, multiple diseases, and people with low immunity are prone to symptoms of spleen deficiency, especially children and the elderly. For children, spleen deficiency may cause a variety of different diseases, such as anorexia, tics or dwarfism. Among them, the main clinical manifestations of anorexia in children are yellowish complexion, malnutrition, backward body shape, poor appetite, unstable stool characteristics, etc.; the main clinical manifestations of tics are involuntary twitching of any part of the body or muscles, etc.; the main clinical manifestations of dwarfism are slow growth and short stature.

[0004] In Western medicine, pediatric anorexia is mainly treated symptomatically, with vitamins, intestinal probiotics, digestive enzymes and other drugs that promote gastrointestinal motility. However, the effect is poor, and long-term use of drugs will cause the body to become dependent on the drugs, which poses certain risks. Conventional treatment for pediatric tics is also based on the use of dopamine receptor blockers, selective monoamine antagonists, anti-epileptic drugs (levetiracetam) and other neurological drugs, which pose certain risks to children's physical development. In Western medicine, dwarfism is mainly treated with growth hormone drugs. Taking too much growth hormone drugs also poses certain risks to children's physical development.

[0005] Various diseases caused by spleen deficiency affect children's growth and development and normal life to varying degrees. Western medicine clinical treatment mostly adopts symptomatic treatment and etiological treatment, which has the disadvantages of long medication time and easy recurrence after discontinuation of medication. Therefore, a safe and reliable treatment method with few side effects and good efficacy is urgently needed.

[0006] Although there are reports of Chinese medicine preparations for treating anorexia, dwarfism or tic disorder in children, they are currently only disclosed to treat one of the diseases, and it is unclear whether they can effectively treat other diseases. Since preparing a Chinese medicine formula requires a lot of time and manpower and material resources, it would be of great significance if a Chinese medicine formula that can effectively treat multiple diseases can be obtained. Summary of the invention

[0007] In view of the problems existing in the above-mentioned prior art, the present invention provides a traditional Chinese medicine composition, an ointment and applications thereof.

[0008] The first object of the present invention is to provide a Chinese medicine composition.

[0009] The second object of the present invention is to provide a Chinese medicine ointment.

[0010] The third object of the present invention is to provide the use of the Chinese medicine composition or the Chinese medicine ointment in the preparation of spleen regulating medicine.

[0011] The fourth object of the present invention is to provide the use of the Chinese medicine composition or the Chinese medicine ointment in the preparation of medicines for treating diseases caused by spleen deficiency.

[0012] A fifth object of the present invention is to provide a medicine for treating anorexia, tics and / or dwarfism in children caused by spleen deficiency.

[0013] The above-mentioned purpose of the present invention is achieved through the following technical solutions:

[0014] The present invention provides a Chinese medicine composition and an ointment thereof, wherein the Chinese medicine composition and the ointment thereof are obtained by the inventor through summarizing long-term clinical experience, adjusting the compatibility of different Chinese medicine pieces and Chinese medicine formula granules, and then continuously summarizing and adjusting the compatibility according to the feedback of patients. The Chinese medicine ointment of the present invention can effectively treat anorexia, tic disorder and / or dwarfism caused by spleen deficiency in children. Therefore, the present invention claims protection for the Chinese medicine composition and the ointment thereof.

[0015] The invention provides a traditional Chinese medicine composition. Specifically, the traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials in parts by weight: 6-20 parts of pseudoginseng, 6-20 parts of yam, 4-10 parts of poria, 3-10 parts of angelica, 3-6 parts of licorice, 6-20 parts of lily, 5-15 parts of lotus seeds, 10-20 parts of rice sprouts, 5-15 parts of hawthorn, 6-15 parts of atractylodes, 2-10 parts of galangal, 4-10 parts of cassia twig, 4-10 parts of white peony root, 5-10 parts of millet stalk vine, 1-5 parts of curcuma, and 4-10 parts of lentil flower.

[0016] Specifically, the Chinese medicine composition is composed of the following Chinese medicine raw materials in parts by weight: 6-20 parts of Pseudostellariae Radix, 6-20 parts of Dioscorea opposita, 4-10 parts of Poria cocos, 3-10 parts of Angelica sinensis, 3-6 parts of Licorice, 6-20 parts of Lilium, 5-15 parts of Lotus seeds, 10-20 parts of Rice sprouts, 5-15 parts of Hawthorn, 6-15 parts of Atractylodes macrocephala, 2-10 parts of Alpinia officinalis, 4-10 parts of Cassia twig, 4-10 parts of White Peony Root, 5-10 parts of Millettia repens, 1-5 parts of Curcuma zedoaria, and 4-10 parts of Phaseolus gramineus.

[0017] More specifically, the Chinese medicine composition is composed of the following Chinese medicine raw materials in parts by weight: 6-12 parts of Pseudostellariae Radix, 6-12 parts of Dioscorea opposita, 4-8 parts of Poria cocos, 3-6 parts of Angelica sinensis, 3-6 parts of Licorice, 6-12 parts of Lilium, 5-10 parts of Lotus seeds, 10-20 parts of Rice sprouts, 5-10 parts of Hawthorn, 6-12 parts of Atractylodes macrocephala, 2-4 parts of Alpinia officinalis, 4-8 parts of Cassia twig, 4-8 parts of White Peony Root, 5-10 parts of Millettia repens, 1-2 parts of Curcuma zedoaria, and 4-8 parts of Phaseolus gramineus.

[0018] More specifically, the Chinese medicine composition is composed of the following Chinese medicine raw materials in parts by weight: 6-7 parts of Pseudostellaria heterophylla, 6-7 parts of Dioscorea opposita, 4-5 parts of Poria cocos, 3-4 parts of Angelica sinensis, 3-4 parts of Licorice, 6-7 parts of Lilium, 5-6 parts of Lotus seeds, 10-11 parts of Rice sprouts, 5-6 parts of Hawthorn, 6-7 parts of Atractylodes macrocephala, 2-3 parts of Alpinia officinarum, 4-5 parts of Cassia twig, 4-5 parts of White Peony Root, 5-6 parts of Millettia repens, 1-2 parts of Curcuma zedoaria, and 4-5 parts of Labiatae Flower.

[0019] More specifically, the Chinese medicine composition is composed of the following Chinese medicine raw materials in parts by weight: 6 parts of Pseudostellaria heterophylla, 6 parts of yam, 4 parts of Poria cocos, 3 parts of Angelica sinensis, 3 parts of Licorice, 6 parts of lily, 5 parts of lotus seeds, 10 parts of rice sprouts, 5 parts of hawthorn, 6 parts of Atractylodes macrocephala, 2 parts of Alpinia officinalis, 4 parts of cinnamon twig, 4 parts of white peony root, 5 parts of Millettia repens, 1 part of Curcuma zedoaria, and 4 parts of Phaseolus gramineus.

[0020] The Chinese medicine composition provided by the present invention is prepared by combining Chinese medicines according to the principle of "monarch, minister, assistant and envoy", and the formula is explained as follows:

[0021] Radix Pseudostellariae is the main drug, which can invigorate the spleen and nourish qi, promote the production of body fluid and moisten the lungs. Atractylodes macrocephala can invigorate the spleen and invigorate qi, yam can balance the lungs, spleen and kidneys, lily can nourish yin and moisten the lungs, lotus seeds can invigorate the spleen and kidneys, angelica can invigorate blood and activate blood circulation, cinnamon can harmonize the nutrient and relieve muscles, white peony can nourish blood and restrain yin, and Poria can invigorate the spleen, promote water and eliminate dampness, and have the functions of regulating the nutrient and sanitation, harmonizing qi and blood, and invigorating yin and stopping sweating. The eight herbs are the ministers, helping the main drugs to invigorate the spleen and replenish deficiency. Alpinia officinalis warms the middle and dispels cold and relieves pain, lentil flower can invigorate the spleen and harmonize the stomach and eliminate dampness, Curcuma zedoaria can promote qi and eliminate accumulation, and Cistanche deserticola can help digestion and invigorate the stomach, eliminate phlegm and relieve cough. Hawthorn and rice sprouts are added to invigorate the spleen, digestion and eliminate accumulation, and protect the spleen and stomach of children, which are all adjuvants. Licorice harmonizes all the herbs and is the guiding drug.

[0022] Specifically, the pharmacological analysis of the above-mentioned Chinese medicine components is as follows:

[0023] Radix Pseudostellariae: sweet, slightly bitter, neutral in nature. Enters the spleen and lung meridians. Functions and indications: replenishes qi and strengthens the spleen, produces body fluid and moistens the lungs. Used for spleen deficiency, fatigue, loss of appetite, weakness after illness, insufficient qi and yin, spontaneous sweating and thirst, dry cough due to lung dryness. At the same time, modern pharmacology shows that Radix Pseudostellariae extract has a protective effect on the gastrointestinal tract.

[0024] Chinese Yam: sweet and neutral in nature. Enters the spleen, lung and kidney meridians. Functions and indications: nourishes the spleen and stomach, promotes the production of body fluids and benefits the lungs, nourishes the kidneys and astringes semen. Used for spleen deficiency, poor appetite, chronic diarrhea, cough and wheezing due to lung deficiency, spermatorrhea due to kidney deficiency, leucorrhea, frequent urination, and thirst due to deficiency heat.

[0025] Poria: sweet, light, and neutral in nature. It enters the heart, lung, spleen, and kidney meridians. Functions and indications: diuresis and dampness removal, spleen strengthening, and heart tranquilization. It is used for edema, oliguria, phlegm and fluid retention, palpitations, spleen deficiency, poor appetite, loose stools, restlessness, palpitations, and insomnia. At the same time, modern pharmacology shows that the tuckahoe polysaccharide in Poria can regulate intestinal flora and improve the intestinal mucosal barrier function.

[0026] Angelica: sweet, pungent, warm, enters the liver, heart, and spleen meridians. Functions and indications: nourishes blood and activates blood circulation, regulates menstruation and relieves pain, moistens the intestines and promotes bowel movements. Used for blood deficiency and sallow complexion, dizziness and palpitations, irregular menstruation, amenorrhea and dysmenorrhea, abdominal pain due to deficiency and cold, rheumatic arthralgia, injuries from falls, carbuncles, ulcers, and constipation due to dry intestines.

[0027] Licorice: sweet and neutral in nature, enters the heart, lung, spleen, and stomach meridians. Functions and indications: tonifies the spleen and replenishes qi, clears away heat and detoxifies, removes phlegm and relieves cough, relieves pain, and harmonizes various medicines. It is used for spleen and stomach weakness, fatigue, palpitations and shortness of breath, cough with sputum, abdominal and limb cramps and pain, carbuncle, sore and ulcer, and relieves drug toxicity and potency.

[0028] Lily: sweet and cold in nature, enters the heart and lung meridians. Functions and indications: nourishes yin and moistens the lungs, clears the heart and calms the mind. Used for yin deficiency and dry cough, cough with blood due to fatigue, restlessness and palpitations, insomnia and dreaminess, and mental confusion.

[0029] Lotus seeds: sweet, astringent, neutral in nature. Enters the spleen, kidney, and heart meridians. Functions and indications: tonifies the spleen and stops diarrhea, stops leukorrhea, benefits the kidney and astringes semen, nourishes the heart and calms the mind. Used for diarrhea due to spleen deficiency, leukorrhea, spermatorrhea, palpitations and insomnia.

[0030] Rice sprouts: sweet and warm in nature. Enter the spleen and stomach meridians. Functions and indications: helps digestion and regulates the stomach, strengthens the spleen and stimulates appetite. Used for indigestion, abdominal distension and bad breath, weak spleen and stomach, and little appetite without hunger.

[0031] Atractylodes macrocephala: bitter, sweet and warm in nature. Enters the spleen and stomach meridians. Functions and indications: invigorates the spleen and replenishes qi, dries dampness and promotes diuresis, stops sweating, and stabilizes the fetus. It is used for spleen deficiency, poor appetite, abdominal distension and diarrhea, phlegm and fluid, dizziness and palpitations, edema, spontaneous sweating, and restless fetuses. At the same time, modern pharmacology shows that the lactone components contained in Atractylodes macrocephala have the effect of regulating gastrointestinal function, protecting and repairing the gastrointestinal mucosa.

[0032] Alpinia officinalis: pungent in nature and hot in flavor. Enters the spleen and stomach meridians. Functions and indications: warms the stomach and stops vomiting, dispels cold and stops pain. Used for cold pain in the abdomen, vomiting due to stomach cold, belching and acid regurgitation.

[0033] Cinnamon twig: pungent, sweet and warm in nature. Enters the heart, lung and bladder meridians. Functions and indications: induces sweating and relieves muscles, warms and dredges the meridians, assists yang and transforms qi, and balances and descends qi. Used for colds, cold pain in the abdomen, amenorrhea due to cold blood, joint pain, phlegm and fluid retention, edema, palpitations, and running pig.

[0034] White peony root: bitter, sour, slightly cold. Enters the liver and spleen meridians. Functions and indications: nourishes blood and regulates menstruation, restrains yin and stops sweating, softens the liver and stops pain, and suppresses liver yang. Used for blood deficiency, chlorosis, irregular menstruation, spontaneous sweating, night sweats, hypochondriac pain, abdominal pain, cramps in the limbs, headache and dizziness.

[0035] Cistanche deserticola: neutral in nature, sweet in taste, slightly bitter. Enters the spleen, stomach, liver, and lung meridians. Functions and indications: dispels heat and dampness, eliminates accumulation, and detoxifies. Used for heatstroke, rheumatic arthralgia, food accumulation, infantile malnutrition, dysentery, jaundice, hepatosplenomegaly, scrofula, intestinal carbuncle, athlete's foot, eczema caused by burns, dermatitis, traumatic injuries, snake bites and scorpion stings.

[0036] Curcuma: pungent, bitter, warm. Enters the spleen and liver meridians. Functions and indications: promotes qi and resolves blood, eliminates stagnation and relieves pain. Used for lumps and masses, blood stasis and amenorrhea, chest pain and heartache, and distension and pain caused by food stagnation.

[0037] Lentil flower: neutral in nature, sweet in taste. Enters the spleen, stomach, and large intestine meridians. Functions and indications: relieves heat and dampness, harmonizes the middle and strengthens the spleen. Treats summer heat and dampness, fever, diarrhea, dysentery, leucorrhea, and swelling caused by falls.

[0038] Hawthorn: sour, sweet, slightly warm in nature. Enters the spleen, stomach, and liver meridians. Functions and indications: helps digestion and invigorates the stomach, promotes qi and dissipates blood stasis, removes turbidity and reduces fat. Used for meat stagnation, fullness in the stomach, abdominal pain due to diarrhea, amenorrhea due to blood stasis, postpartum blood stasis, stabbing pain in the heart and abdomen, chest pain, hernia pain, and hyperlipidemia. The effect of charred hawthorn on digestion and stagnation is enhanced. Used for meat stagnation and diarrhea. At the same time, modern pharmacology shows that hawthorn is rich in vitamin C, vitamin B2, carotene, and various organic acids, which can promote the secretion of digestive enzymes, enhance the role of enzymes in the stomach, and play a role in digestion, appetizing, and increasing appetite.

[0039] Based on the Chinese medicine composition, the present invention also provides a Chinese medicine ointment.

[0040] Specifically, the Chinese medicine ointment is prepared from the above-mentioned Chinese medicine composition.

[0041] The preparation of the traditional Chinese medicine ointment provided by the present invention can be carried out according to a conventional ointment preparation method.

[0042] As an optional embodiment, specifically, the preparation method of the traditional Chinese medicine ointment can be: decocting the traditional Chinese medicine composition with water to obtain a decoction, adding a sweetener, and concentrating to obtain the decoction.

[0043] The sweeteners include natural sweeteners such as brown sugar, black sugar, maltose or honey.

[0044] Specifically, the decoction is concentrated to a relative density of 1.2 to 1.4.

[0045] Specifically, 500-1200 mL of water is added to each dose of the Chinese medicine composition for decoction for 2-3 times, and the combined decoction is added with 0.7-0.9 g of brown sugar and concentrated to a relative density of 1.2-1.4.

[0046] More specifically, each dose of the Chinese medicine composition is decocted with 600 mL of water, decocted twice, and the combined decoctions are added with 0.8 g of brown sugar and concentrated to a relative density of 1.3.

[0047] The Chinese medicine ointment has good clinical therapeutic effect in treating anorexia, dwarfism and tic disorder in children caused by spleen deficiency. Therefore, the present invention further requests the protection of the use of the Chinese medicine composition or the Chinese medicine ointment in the preparation of spleen regulating medicine.

[0048] Specifically, the spleen-regulating medicine is a spleen-regulating medicine for children.

[0049] The present invention also applies to protect the use of the Chinese medicine composition or the Chinese medicine ointment in preparing medicines for treating diseases caused by spleen deficiency.

[0050] Specifically, the diseases caused by spleen deficiency are anorexia, tics and / or dwarfism.

[0051] The present invention also claims a medicine for treating anorexia, tic disorder and / or dwarfism in children caused by spleen deficiency.

[0052] Specifically, the medicine contains the Chinese medicine composition or the Chinese medicine ointment of the present invention.

[0053] Specifically, the drug also contains pharmaceutically acceptable excipients.

[0054] Specifically, the dosage form of the drug is tablets, capsules, oral liquids, pills, granules, pastes, powders, mixtures or syrups.

[0055] The present invention has the following beneficial effects:

[0056] The present invention provides a Chinese medicine composition and its ointment. The Chinese medicine composition contains Radix Pseudostellariae Radix, Rhizoma Dioscoreae, Poria, Angelicae Sinensis, Licorice, Lilium, Lotus Seed, Rice Bud, Crataegus Pinelliae, Atractylodes Macrocephalae, Alpinia Officinalis, Cinnamomum Cassiae, Paeonia lactiflora, Rhizoma Curcumae, and Radix Phaseolifoliae, which is obtained based on long-term summary and continuous adjustment of compatibility. The ointment made from the Chinese medicine composition of the present invention can effectively treat anorexia, tic disorder and / or dwarfism caused by spleen deficiency in children. According to clinical case data statistics, the total effective rates of using the ointment made from the Chinese medicine composition of the present invention to treat anorexia, tic disorder and dwarfism caused by spleen deficiency in children are 92%, 100% and 100%, respectively, and the treatment effect is good. That is, the Chinese medicine composition of the present invention can be used to prepare drugs for treating anorexia, dwarfism, tic disorder and the like in children caused by spleen deficiency. In addition, the Chinese medicine ointment prepared from the Chinese medicine composition of the present invention has the advantages of high medicine content, good taste, convenient administration, and easy acceptance, and is beneficial for treating diseases caused by spleen deficiency. DETAILED DESCRIPTION

[0057] The present invention is further described below with reference to specific examples, but the examples do not limit the present invention in any form. Unless otherwise specified, the reagents, methods and equipment used in the present invention are conventional reagents, methods and equipment in the art.

[0058] Unless otherwise specified, the reagents and materials used in the following examples are commercially available.

[0059] Embodiment 1 A kind of Chinese medicine ointment

[0060] 1. Composition of Chinese medicine ointment

[0061] The Chinese medicine ointment described in this embodiment is prepared from the following Chinese medicine raw materials in parts by weight: 6g of Pseudostellaria heterophylla, 6g of yam, 4g of Poria, 3g of Angelica sinensis, 3g of Licorice, 6g of Lilium, 5g of Lotus Seed, 10g of Rice Bud, 5g of Hawthorn, 6g of Atractylodes macrocephala, 2g of Alpinia officinalis, 4g of Cassia twig, 4g of White Peony Root, 5g of Millettia repens, 1g of Curcuma zedoaria, and 4g of Phaseolus odoratus.

[0062] 2. Preparation method of Chinese medicine ointment

[0063] (1) Extraction and preparation of paste: extract under normal pressure and concentrate under reduced pressure to decoct the paste; take 1000 doses (the weight of the above formula is 1 dose) of the medicinal material slices, add 600 liters of water and boil to 100°C, boil for 60 minutes, boil twice, add 800 g of brown sugar, combine the two decoctions and concentrate to a relative density of 1.30 to obtain a Chinese medicine paste.

[0064] (2) Packaging of Chinese herbal ointment: Use 304 stainless steel barrels to hold the prepared Chinese herbal ointment and package it with polyester / low-density polyethylene medicinal composite film (the packaging material implementation standard is: YBB00182002~2015), each package (dose) is 8 ml.

[0065] 3. Usage and dosage of Chinese medicine ointment

[0066] Usage of Chinese medicine ointment: Take with warm water. The dosage is: 1-2 years old, half a dose each time, once a day, 4 ml each time; 2-5 years old, 1 dose each time, 2 times a day, 8 ml each time; 5-10 years old, 1 dose each time, 3 times a day, 8 ml each time.

[0067] Embodiment 2 A kind of Chinese medicine ointment

[0068] 1. Composition of Chinese medicine ointment

[0069] The Chinese medicine ointment described in this embodiment is prepared from the following Chinese medicine raw materials in parts by weight: 12g of Pseudostellaria heterophylla, 12g of yam, 8g of Poria, 6g of Angelica sinensis, 6g of Licorice, 12g of Lilium, 10g of Lotus Seed, 20g of Rice Bud, 10g of Hawthorn, 12g of Atractylodes macrocephala, 4g of Alpinia officinalis, 8g of Cassia twig, 8g of White Peony Root, 10g of Cistanche deserticola, 2g of Curcuma, and 8g of Phaseolus flower.

[0070] 2. Preparation method of Chinese medicine ointment

[0071] (1) Extraction and preparation of paste: extract under normal pressure and concentrate under reduced pressure to decoct the paste; take 1000 doses (the weight of the above formula is 1 dose) of the medicinal material slices, add 1200 liters of water and boil to 100°C, boil for 60 minutes, boil twice, add 800 g of brown sugar, combine the two decoctions and concentrate to a relative density of 1.30 to obtain a Chinese medicine paste.

[0072] (2) Packaging of Chinese herbal ointment: Use 304 stainless steel barrels to hold the prepared Chinese herbal ointment and package it with polyester / low-density polyethylene medicinal composite film (the packaging material implementation standard is: YBB00182002~2015), each package (dose) is 15 ml.

[0073] 3. Usage and dosage of Chinese medicine ointment

[0074] Usage of Chinese medicine ointment: Take with warm water. The dosage is: 1 dose each time for 10-14 years old, 2 times a day, 15 ml each time; 14 years old and above, 1 dose each time, 3 times a day, 15 ml each time.

[0075] Embodiment 3 a kind of Chinese medicine ointment

[0076] 1. Composition of Chinese medicine ointment

[0077] The Chinese medicine ointment described in this embodiment is prepared from the following Chinese medicine raw materials in parts by weight: 20g of Pseudostellaria heterophylla, 20g of yam, 10g of Poria, 10g of Angelica sinensis, 6g of Licorice, 20g of Lilium, 15g of Lotus Seed, 20g of Rice Bud, 15g of Hawthorn, 15g of Atractylodes macrocephala, 10g of Alpinia officinalis, 10g of Cassia twig, 10g of White Peony Root, 10g of Millettia repens, 5g of Curcuma, and 10g of Phaseolus Flos.

[0078] 2. Preparation method of Chinese medicine ointment

[0079] (1) Extraction and preparation of paste: extract under normal pressure and concentrate under reduced pressure to decoct the paste; take 1000 doses (the weight of the above formula is 1 dose) of the medicinal material slices, add 1200 liters of water and boil to 100°C, boil for 60 minutes, boil twice, add 800 g of brown sugar, combine the two decoctions and concentrate to a relative density of 1.30 to obtain a Chinese medicine paste.

[0080] (2) Packaging of Chinese herbal ointment: Use 304 stainless steel barrels to hold the prepared Chinese herbal ointment and package it with polyester / low-density polyethylene medicinal composite film (the packaging material implementation standard is: YBB00182002~2015), each package (dose) is 15 ml.

[0081] 3. Usage and dosage of Chinese medicine ointment

[0082] Usage of Chinese medicine ointment: Take with warm water. The dosage is: 1 dose for adults, 3 times a day, 15 ml each time.

[0083] Example 4 Comparison of clinical efficacy of Chinese medicinal ointment in treating anorexia in children

[0084] 1. Research Methods

[0085] 100 children with anorexia who visited Meizhou Traditional Chinese Medicine Hospital from January 2023 to June 2024 were divided into an observation group and a control group according to the random number table method, with 50 cases in each group. The control group was treated with Xingpi Yanger Granules, and the observation group was treated with the spleen-regulating Chinese medicine ointment described in Example 1 (implemented according to the usage and dosage in Example 1). The two groups were treated for 1 month, and the clinical efficacy (total effective rate) and the total score of TCM syndrome were compared.

[0086] 2. Observation indicators

[0087] (1) Clinical efficacy: The efficacy index was calculated by referring to the “Efficacy Standards for Diagnosis and Efficacy of TCM Diseases and Syndromes” and the scores before and after treatment were calculated according to the nimodipine scoring method (efficacy index = (symptom score before treatment - symptom score after treatment) / symptom score before treatment × 100%). The efficacy index was divided into four efficacy evaluation levels: cured, markedly effective, effective, and ineffective. Cured: TCM clinical symptoms and signs disappeared or basically disappeared, and the symptom score decreased by ≥95%; markedly effective: TCM clinical symptoms and signs were significantly improved, and the symptom score decreased by ≥70%; effective: TCM clinical symptoms and signs were improved, and the symptom score decreased by ≥30%; ineffective: TCM clinical symptoms and signs were not significantly improved, or even aggravated, and the symptom score decreased by <30%.

[0088] (2) TCM syndrome scoring: The scoring criteria refer to the "Guidelines for Clinical Research of New Chinese Medicines" and "Chinese Pediatrics" (China Traditional Chinese Medicine Press, 2021 edition). Nine aspects are evaluated, including anorexia or refusal to eat, nausea and vomiting, abdominal distension, weight loss, subcutaneous fat loss, sweating, complexion, mental state, and stool characteristics. According to the severity, the symptoms are divided into four levels: none, mild, moderate, and severe, with 0, 1, 2, and 3 points respectively. A total score of <10 points is mild; 10-20 points is moderate; >20 points is severe.

[0089] 3. Treatment results

[0090] After one month of treatment, the total effective rate was calculated based on the results of the clinical efficacy survey (total effective rate = (total number of patients - ineffective number of patients) / total number of patients × 100%). The total effective rate of the observation group of 50 patients randomly divided into groups was 92.00%, which was significantly higher than that of the control group (the total effective rate of the control group was 82.00%), and the difference was statistically significant (P<0.05). In addition, the total score of TCM syndromes in both groups decreased significantly, but the observation group was significantly lower than the control group, and the difference was statistically significant (P<0.05).

[0091] The above results show that the Chinese medicinal ointment of the present invention has a good effect in treating anorexia in children and can significantly improve the clinical symptoms of children with anorexia.

[0092] In addition, by following up 43 children with anorexia and spleen and stomach conditioning in Meizhou Traditional Chinese Medicine Hospital from 2019 to 2020, it was found that the Chinese medicine prescription used for their treatment had 8 to 15 Chinese medicine raw materials and the same dosage as the prescription of the ointment described in Example 1 of the present invention. According to the feedback on the efficacy, from the perspective of symptom score evaluation, 6 of them were significantly effective, 15 were effective, and 22 were ineffective, with an overall effective rate of 48.84%.

[0093] Among them, invalid case 1: He, female, 5 years old. On September 3, 2019, she came to the hospital for treatment due to poor appetite for 1 month. She occasionally cried at night, but there was nothing special about her. Her bowel movements were normal. Physical examination: well-proportioned body, normal development, slightly yellow complexion, no yellow pupils, and no abnormalities in the heart, lungs, and abdomen. The tongue was pale red with white fur.

[0094] Clinical diagnosis and treatment methods are as follows:

[0095] (1) TCM diagnosis: poor appetite (spleen deficiency);

[0096] (2) Therapeutic principles: replenishing Qi and strengthening the spleen;

[0097] (3) Treatment method: Radix Pseudostellariae 6g, Rhizoma Dioscoreae 6g, Poria 4g, Radix Glycyrrhizae 3g, Bulbus Lilii 6g, Bulbus Lilii 5g, Rice Bud 10g, Fructus Hawthorne 5g, Rhizoma Atractylodis Macrocephalae 6g, Rhizoma Coptidis 5g, Fructus Lablab 4g, Paeoniae Alba 4g, Rhizoma Uncariae 5g. Chinese medicine formula granules, 2 times a day, one pack each time, for 2 consecutive weeks.

[0098] (4) Treatment efficacy: On September 30, 2019, the child's night crying was relieved, but he still ate less and his body shape did not change significantly. His tongue was pale red with a thin white coating.

[0099] Invalid case 2: Lin, male, 8 years old. On October 9, 2019, he came to the hospital for treatment due to poor appetite for 2 months. The child has a history of recurrent respiratory tract infections in the past six months. Current symptoms: poor appetite, sweating, no cough and other discomfort, good sleep, normal bowel movements. Physical examination: mental state, relevant answers, thin body, slightly yellow complexion, no yellow pupils, no abnormalities in heart, lungs and abdomen. Pale red tongue, thin white fur, fine pulse.

[0100] Clinical diagnosis and treatment methods are as follows:

[0101] (1) TCM diagnosis: poor appetite (spleen deficiency);

[0102] (2) Therapeutic principles: replenishing Qi and strengthening the spleen;

[0103] (3) Treatment method: Pseudostellariae Radix 6g, Chinese Yam 6g, Poria 4g, Angelicae Sinensis 3g, Licorice 3g, Lilium 6g, Lotus Seed 5g, Rice Bud 10g, Hawthorn 5g, Atractylodes 6g, Alpinia Officinarum 2g, Cinnamon Twig 4g, White Peony 4g, Uncaria Rhynchophylla 5g, Curcuma 1g, Lentil Flower 4g. Chinese medicine formula granules, twice a day, one pack each time, for 2 consecutive weeks.

[0104] (4) Treatment efficacy: On October 23, 2019, the patient was reexamined and had a cough and runny nose. His appetite was still poor, but his sweating decreased and his complexion was slightly rosier than before. His body shape did not change significantly. His tongue was pale red, with a thin white coating and a thready pulse.

[0105] Example 5 Chinese medicinal ointment for treating dwarfism and tic syndrome in children

[0106] The Chinese medicine ointment of the present invention can also be used to treat dwarfism and pediatric tics. According to statistics from the HIS medical record system of Meizhou Traditional Chinese Medicine Hospital, in 2022, there were 125 patients with poor appetite, anorexia, and malnutrition, and 13 patients with pediatric tics, all of whom used the Chinese medicine ointment of the present invention. Among them, the total effective rate of patients with poor appetite, anorexia, and malnutrition was 94.4%, 38 people were cured, with a cure rate of 30.4%, 40 people were significantly effective, with a significant effective rate of 32%, 40 people were effective, with an effective rate of 32%, 7 people were ineffective, with an ineffective rate of 5.6%; the total effective rate of patients with pediatric tics was 100%.

[0107] Follow-up of 6 children with dwarfism, namely Ke, Yao, Wei, Shi, Liu and Fan, who were admitted to Meizhou Traditional Chinese Medicine Hospital in 2022, showed that their appetite improved and their height growth increased after treatment with the Chinese medicine ointment described in the present invention (course of treatment for 1 to 2 months), with a total effective rate of 100%.

[0108] Typical case histories are as follows:

[0109] 1. Case 1 (significantly effective)

[0110] Fan, male, 2 years old. On February 11, 2022, he came to the hospital for conditioning because his height had not increased for half a year and his weight had not increased for a year. Physical examination: weight 10Kg, height 82cm, sallow complexion, no abnormalities in heart and lung examination, slightly bulging abdomen, soft muscles, no tenderness, etc. The tongue is pale red with a thin white coating.

[0111] Clinical diagnosis and treatment methods are as follows:

[0112] (1) TCM diagnosis: malnutrition (spleen deficiency with accumulation); Western medicine diagnosis: dwarfism;

[0113] (2) Therapeutic principles: replenishing qi, harmonizing the stomach and strengthening the spleen;

[0114] (3) Treatment method: Take the Chinese medicine ointment described in Example 1, twice a day, one packet (8 ml per packet), add 100 ml of warm water and take it warm after meals, take it for 6 consecutive days and stop for 1 day, and continue taking the Chinese medicine ointment for 3 months.

[0115] At the same time, acupuncture treatment was performed on the Sifeng acupoint once every two weeks for three times in a row.

[0116] (4) Treatment efficacy: On May 19, 2022, the child's appetite improved, his complexion was yellow, but better than before. Physical examination: weight 11.5 kg, height 85 cm, no abnormalities in the heart, lungs and abdomen, slightly distended abdomen, soft muscles, no tenderness, etc. The tongue was pale red with a thin white coating.

[0117] 2. Case 2 (cured)

[0118] Chen Moumou, male, 4 years old. Came to the hospital for treatment on December 4, 2022 because of finger twitching for half a month. The child had irregular finger twitching due to emotional tension half a month ago, accompanied by frequent blinking and involuntary twitching of the nose, which could be relieved on his own. He had been to the local maternal and child health care hospital for treatment, but there was no obvious relief after treatment. The main symptoms now are: frequent blinking, involuntary nasal twitching, and twitching of both fingers, all of which are paroxysmal attacks, which can be relieved on their own, with a slightly yellow complexion, general appetite, dislike of meat, sweating, irritable temper, good sleep, and normal bowel movements. The tongue is pale red, the coating is white, and the pulse is stringy and thin. Personal history: history of multiple upper respiratory tract infections and history of allergic rhinitis. Allergy history: allergic to milk and dust mites, and denies a history of drug allergies. Family history: There is no similar history in the family, and the family history of genetic diseases is denied.

[0119] Clinical diagnosis and treatment methods are as follows:

[0120] (1) TCM diagnosis: pediatric tics (liver and spleen disorders); Western medicine diagnosis: pediatric tics, allergic rhinitis;

[0121] (2) Therapeutic principles: Strengthen the spleen and replenish qi, soften the liver and dissipate wind;

[0122] (3) Treatment method: Take the Chinese medicine ointment described in Example 1, twice a day, one packet (8 ml per packet) at a time, before bedtime, add 100 ml of warm water and drink it after meals, take it for 6 consecutive days and stop for 1 day.

[0123] (4) Treatment efficacy: The patient was followed up by phone 2 weeks after taking the medicine. He said his complexion had returned to normal, his hand, eye blinking, and nasal twitching had disappeared, his appetite had improved, and his sweating had decreased. He was unable to be re-examined due to being out of town, so he was temporarily observed.

[0124] The comparison cases are as follows:

[0125] 1. Case 1

[0126] Zhang, male, 5 years old. On July 3, 2018, he came to the hospital for treatment due to poor appetite and lack of height growth for half a year. He usually sweats a lot, has poor appetite, is easily agitated, and has normal bowel movements. Physical examination: weight 16Kg, height 104cm, thin body, slightly yellow complexion, no yellow pupils, no abnormalities in heart and lung examination, slightly distended abdomen, no tenderness or other discomfort. Pale red tongue, white fur.

[0127] Clinical diagnosis and treatment methods are as follows:

[0128] (1) TCM diagnosis: malnutrition (spleen deficiency with accumulation); Western medicine diagnosis: dwarfism;

[0129] (2) Therapeutic principles: Eliminate stagnation and strengthen the spleen;

[0130] (3) Treatment method: Pseudostellariae Radix 6g, Chinese Yam 6g, Poria 4g, Licorice 3g, Lily 6g, Lotus Seed 5g, Rice Bud 10g, Hawthorn 5g, Atractylodes 6g, Millettia 5g, Curcuma 1g, Lentil Flower 4g. Chinese medicine formula granules, twice a day, one pack each time, for 2.5 months.

[0131] At the same time, acupuncture treatment was performed on the Sifeng acupoint once every two weeks for three times in a row.

[0132] (4) Treatment efficacy: On October 19, 2018, the child's appetite improved, his yellow complexion improved, his emotional agitation improved, and his body shape did not change significantly. Physical examination: weight 16 kg, height 105 cm, no abnormalities in the heart, lungs, and abdomen, slightly distended abdomen, soft muscles, no tenderness, etc. The tongue was pale red with a thin white coating.

[0133] 2. Medical Record 2

[0134] Li, male, 9 years old. On July 4, 2018, he came to the hospital for treatment due to frequent blinking and twitching of the corners of his mouth for 2 weeks. The child began to blink frequently and twitch the corners of his mouth after being educated by his family 2 weeks ago. He did not scream, twitch his limbs, or have fever, cough, runny nose or other discomfort. He had been to the local People's Hospital for treatment. The relevant examinations such as cranial magnetic resonance imaging and electroencephalogram showed no abnormalities. So he came to the hospital for treatment. Symptoms: frequent blinking, twitching of the corners of the mouth, sweating, poor appetite, good sleep, and normal bowel movements. Physical examination: clear mind, few words, thin body, slightly yellow complexion, no yellow pupils, and no abnormalities in the heart, lungs, and abdomen. The tongue is pale red, the tongue coating is white, and the pulse is stringy and thin.

[0135] Clinical diagnosis and treatment methods are as follows:

[0136] (1) TCM diagnosis: pediatric tics (liver and spleen disorders);

[0137] (2) Therapeutic principles: replenishing Qi and strengthening the spleen, softening the liver and calming the wind;

[0138] (3) Treatment methods:

[0139] Pseudostellariae Radix 6g, Chinese Yam 6g, Poria 4g, Angelicae Sinensis 3g, Licorice 3g, Lilium 6g, Lotus Seed 5g, Rice Bud 10g, Hawthorn 5g, Atractylodes 6g, Tribulus 5g, Uncaria 5g, White Peony 4g, Millettia 5g, Lentil Flower 4g. Chinese medicine formula granules, twice a day, one pack each time, for 2 consecutive weeks.

[0140] (4) Treatment efficacy: On July 18, 2018, the family was contacted by phone and reported that the child’s blinking and mouth twitching had not improved. The child had gone to the provincial hospital for treatment but had not received a follow-up visit.

[0141] The above embodiments are preferred implementation modes of the present invention, but the implementation modes of the present invention are not limited to the above embodiments. Any other changes, modifications, substitutions, combinations, and simplifications that do not deviate from the spirit and principles of the present invention should be equivalent replacement methods and are included in the protection scope of the present invention.

Claims

1. A Chinese medicine composition, characterized in that: The invention comprises the following Chinese medicinal raw materials in parts by weight: 6-20 parts of pseudoginseng, 6-20 parts of yam, 4-10 parts of poria, 3-10 parts of angelica, 3-6 parts of licorice, 6-20 parts of lily, 5-15 parts of lotus seeds, 10-20 parts of rice sprouts, 5-15 parts of hawthorn, 6-15 parts of atractylodes, 2-10 parts of galangal, 4-10 parts of cassia twig, 4-10 parts of white peony root, 5-10 parts of millet spatholobi, 1-5 parts of curcuma and 4-10 parts of lentil flower.

2. The Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition is composed of the following Chinese medicine raw materials in parts by weight: 6-20 parts of Pseudostellaria heterophylla, 6-20 parts of Chinese yam, 4-10 parts of Poria cocos, 3-10 parts of Chinese angelica, 3-6 parts of liquorice, 6-20 parts of lily, 5-15 parts of lotus seeds, 10-20 parts of rice sprouts, 5-15 parts of hawthorn, 6-15 parts of Atractylodes macrocephala, 2-10 parts of Alpinia officinarum, 4-10 parts of cinnamon twig, 4-10 parts of white peony root, 5-10 parts of Cistanche deserticola, 1-5 parts of Curcuma zedoaria, and 4-10 parts of Labiatae flower.

3. The Chinese medicine composition according to claim 2, characterized in that: The Chinese medicine composition is composed of the following Chinese medicine raw materials in parts by weight: 6-12 parts of Pseudostellariae Radix, 6-12 parts of Dioscorea opposita, 4-8 parts of Poria cocos, 3-6 parts of Angelica sinensis, 3-6 parts of Licorice, 6-12 parts of Lilium, 5-10 parts of Lotus seeds, 10-20 parts of Rice sprouts, 5-10 parts of Hawthorn, 6-12 parts of Atractylodes macrocephala, 2-4 parts of Alpinia officinarum, 4-8 parts of Cinnamomum cassia twig, 4-8 parts of White Peony Root, 5-10 parts of Cnidium officinale, 1-2 parts of Curcuma zedoaria, and 4-8 parts of Lablab Bean Flower.

4. The Chinese medicine composition according to claim 3, characterized in that: The Chinese medicine composition is composed of the following Chinese medicine raw materials in parts by weight: 6-7 parts of Pseudostellaria heterophylla, 6-7 parts of Chinese yam, 4-5 parts of Poria cocos, 3-4 parts of Chinese angelica, 3-4 parts of liquorice, 6-7 parts of lily, 5-6 parts of lotus seeds, 10-11 parts of rice sprouts, 5-6 parts of hawthorn, 6-7 parts of Atractylodes macrocephala, 2-3 parts of Alpinia officinarum, 4-5 parts of cinnamon twig, 4-5 parts of white peony root, 5-6 parts of Cistanche deserticola, 1-2 parts of Curcuma zedoaria, and 4-5 parts of Labiatae flower.

5. The Chinese medicine composition according to claim 4, characterized in that: The Chinese medicine composition is composed of the following Chinese medicine raw materials in parts by weight: 6 parts of Pseudostellaria heterophylla, 6 parts of Chinese yam, 4 parts of Poria cocos, 3 parts of Chinese angelica, 3 parts of licorice, 6 parts of lily, 5 parts of lotus seeds, 10 parts of rice sprouts, 5 parts of hawthorn, 6 parts of Atractylodes macrocephala, 2 parts of Alpinia officinalis, 4 parts of cinnamon twig, 4 parts of white peony root, 5 parts of Cistanche deserticola, 1 part of Curcuma zedoaria, and 4 parts of Lablab lentil flower.

6. A Chinese medicine ointment, characterized in that: It is prepared from the Chinese medicine composition according to any one of claims 1 to 5.

7. Use of the Chinese medicine composition according to any one of claims 1 to 5 or the Chinese medicine ointment according to claim 6 in the preparation of spleen-regulating medicines.

8. Use of the Chinese medicine composition according to any one of claims 1 to 5 or the Chinese medicine ointment according to claim 6 in the preparation of a medicament for treating diseases caused by spleen deficiency, wherein the diseases caused by spleen deficiency are anorexia, tic disorder and / or dwarfism.

9. A drug for treating anorexia, tic disorder and / or dwarfism in children caused by spleen deficiency, characterized in that: Contains the Chinese medicine composition according to any one of claims 1 to 5 or the Chinese medicine ointment according to claim 6.

10. The drug according to claim 9, characterized in that: The dosage form of the medicine is tablet, capsule, oral liquid, pill, granule, paste, powder, mixture or syrup.