Connecting device

Abstract

Provided are a connection device in which flow stagnation does not readily occur, and a method for manufacturing the same. A connection device (1) having an inner chamber (9) for connecting a flow path (3) to a housing (7) containing a membrane (5) in a state in which a liquid can be conveyed, and having a plurality of flow path adjustment walls (13) provided in the inner chamber (9); also provided is a method for manufacturing the connection device (1), which comprises: a step for providing a plurality of virtual flow path layers having a thickness corresponding to the inter-film flow paths (17) formed by the plurality of laminated films (5) on the main body part (11) of the connection device (1); a step for forming a plurality of flow path adjustment walls (13) between the plurality of virtual flow path layers; and a step for obtaining an inter-adjustment-wall flow path (15) formed by the plurality of flow path adjustment walls (13) by removing the virtual flow path layer after the plurality of flow path adjustment walls (13) are formed.

Description

Technical Field

[0001] The present invention relates to a connecting device for connecting a flow path and a membrane. The present invention relates to a connecting device used when connecting, for example, a blood flow path and a medical device body having a membrane. Background Art

[0002] Japanese Patent Publication No. 2017-158814 describes a blood filtration device. The main body of the device has a plurality of blood flow path layers, a filter membrane, and a filtrate flow path layer. Moreover, each blood inlet of each blood flow path layer of the device is connected to a blood inlet. Therefore, when blood flows in the device, there will be a change in the direction of the blood flow and a change in the diameter. Moreover, in the device, blood will also adhere to the end surface of the layered material. As a result, blood will be retained in the device, which will cause thrombosis.

[0003] Prior art literature

[0004] Patent Literature

[0005] Patent Document 1: Japanese Patent Application Publication No. 2017-158814 Summary of the invention

[0006] Technical issues that the invention aims to solve

[0007] An object of the present invention is to provide a connecting device in which the flow of a liquid is less likely to stagnate when a flow path is connected to a housing accommodating a membrane.

[0008] Specifically, an object of the present invention is to provide a connection device that can reduce the occurrence of thrombosis when connecting a blood flow path and a medical device having a membrane.

[0009] Technical solutions to problems

[0010] The above-mentioned problems are basically based on the knowledge that the flow path of the liquid can be adjusted by providing a plurality of flow path adjustment walls in the inner cavity of the connection device.

[0011] The first invention described in this specification relates to a connecting device 1. The connecting device 1 is a device for connecting a flow path 3 to a housing 7 in a state where liquid can be transported. The connecting device 1 has a plurality of flow path adjustment walls 13 provided in an inner cavity 9. The liquid from the flow path 3 is transmitted to the housing 7 through the inner cavity 9 of the connecting device 1. The housing 7 contains a membrane 5. Therefore, the liquid from the flow path 3 is transmitted to the membrane 5 through the inner cavity 9 of the connecting device 1. At this time, the flow of the liquid is adjusted by the plurality of flow path adjustment walls 13.

[0012] The next invention described in this specification is a method for manufacturing the above-mentioned connecting device 1.

[0013] This method includes a step of providing a virtual flow path layer, a step of forming a flow path adjustment wall, and a step of obtaining a flow path between the adjustment walls.

[0014] The virtual flow path layer providing step is a step of providing a plurality of virtual flow path layers 23 having a thickness corresponding to the inter-membrane flow paths 17 formed by the plurality of laminated films 5 in the main body portion 11 of the connection device 1 .

[0015] The flow path regulating wall forming step is a step for forming a plurality of flow path regulating walls 13 between a plurality of virtual flow path layers 23 .

[0016] The inter-adjustment-wall flow path obtaining step is a step of removing the virtual flow path layer 23 after forming a plurality of flow path adjusting walls 13 , thereby obtaining the inter-adjustment-wall flow paths 15 formed by the plurality of flow path adjusting walls 13 .

[0017] Effects of the Invention

[0018] The present invention is provided with a plurality of flow path adjustment walls to adjust the flow path of the liquid. Thus, when the flow path is connected to the housing containing the membrane, the flow of the liquid can be prevented from stagnating. The connecting device has a plurality of flow path adjustment walls, so when the blood flow path is connected to the membrane, the occurrence of thrombosis can be reduced. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] [ Figure 1 ] Figure 1 This is a conceptual diagram of the connection device.

[0020] [ Figure 2 ] Figure 2 This is a conceptual diagram showing how a connection device, a flow path, and a housing are connected.

[0021] [ Figure 3 ] Figure 3 This is a conceptual diagram showing how liquid from the flow path is transferred to the membrane inside the housing via the inner cavity of the connecting device. Figure 3 (a) is a diagram for explaining the prior art. Figure 3 (b) is a diagram for explaining the present invention.

[0022] [ Figure 4 ] Figure 4 This is a conceptual diagram for explaining the process of setting up a virtual flow path layer. Figure 4 (a) is a diagram showing a case where a plurality of sheets are provided. Figure 4 (b) is a diagram showing a state where a plurality of sheets are put together. Figure 4 (c) is a diagram showing a state where a cover is installed.

[0023] [ Figure 5 ] Figure 5 This is a conceptual diagram for explaining the process of forming the flow path regulating wall. Figure 5(a) is a diagram showing a state where a resin is put into a cap. Figure 5 (b) is a diagram showing a state in which the resin is cured.

[0024] [ Figure 6 ] Figure 6 It is a diagram for explaining the process of adjusting the inter-wall flow path acquisition. Figure 6 (a) is a conceptual diagram showing a situation when the virtual flow path layer is removed. Figure 6 (b) is a diagram showing a state where the connection device is obtained by removing the cover.

[0025] [ Figure 7 ] Figure 7 An exploded view of the blood filtration device.

[0026] [ Figure 8 ] Figure 8 It is a photograph which replaces the drawing and shows the connection device obtained in Example.

[0027] [ Fig. 9 ] Fig. 9 A photograph is provided to replace a drawing showing an example of use of the connection device. Fig. 9 (a) shows the case where a connection device without a flow path regulating wall is used. Fig. 9 (b) shows an example of using a connecting device provided with a flow path regulating wall. DETAILED DESCRIPTION

[0028] Hereinafter, the embodiment of the present invention will be described using the drawings. The present invention is not limited to the embodiment described below, and also includes an embodiment appropriately modified within the scope that should be understood by those skilled in the art based on the following embodiment.

[0029] Figure 1 This is a conceptual diagram of the connection device. Figure 1 As shown in FIG. 1 , the connection device 1 includes a main body 11, an inner cavity 9 as an inner space of the main body 11, and a plurality of flow path adjustment walls 13 provided in the inner cavity 9. Figure 1 As shown, an inter-adjustment-wall flow path 15 is formed between two adjacent walls of the plurality of flow path adjustment walls 13 present in the inner chamber 9. An inter-adjustment-wall flow path 15 may also be formed between the wall surface of the inner chamber 9 and the outermost flow path adjustment wall 13. Figure 1 In addition to the connection device 1 , a flow path 3 and a housing 7 are depicted. Figure 2 This is a conceptual diagram showing how a connection device, a flow path, and a housing are connected.

[0030] The connecting device 1 is a device for connecting the flow path 3 to the housing 7 in a state where liquid can be transported. The connecting device 1 is a device for reducing the stagnation of liquid and transporting liquid from the flow path 3 to the membrane 5 in the housing 7. Therefore, when the inner diameter of the end of the flow path 3 is different from the inner diameter of the end of the housing 7, this connecting device 1 can be preferably used. The connecting device 1 can be used to connect the blood flow path and the part that accommodates the membrane in, for example, an implantable artificial kidney, a portable artificial kidney, a hemodialyzer (dialyzer), a blood filter (hemofiltration device), an extracorporeal membrane oxygenation (ECMO) or a continuous hemofiltration dialyzer. In medical equipment, this connecting device 1 can be preferably used to guide blood from the blood flow path to the membrane.

[0031] The connecting device 1 can be formed using known materials. Examples of the materials of the connecting device 1 are polyvinyl chloride, polyethylene, polypropylene, cyclic polyolefin, polystyrene, polycarbonate, acrylic resin, methacrylic resin, acrylonitrile-butadiene-styrene copolymer, polyethylene terephthalate, butadiene-styrene copolymer, polyamide (e.g., nylon 6, nylon 6 / 6, nylon 6 / 10, nylon 12), natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, silicone rubber, various thermoplastic elastomers, PTFE (polytetrafluoroethylene), ePTFE (expanded polytetrafluoroethylene), titanium, stainless steel, aluminum, copper, and copper-based alloys.

[0032] The connection device 1 may be in a shape that matches the flow path 3 and the housing 7. The shape of the connection device 1 or the inner cavity 9 or the main body 11 therein may also be appropriately matched to the application.

[0033] Flow path 3

[0034] The flow path 3 is a passage for liquid, and is connected to the housing 7 via the connecting device 1, whereby the liquid in the flow path 3 is transmitted to the membrane in the housing 7. Examples of liquids flowing through the flow path are blood, dialysate, dew, saline, perfusion fluid, drip solution, and water. Among them, blood is preferred. Examples of the inner diameter of the flow path 3 are 2 mm or more and 2 cm or less. The inner diameter of the flow path can be 2 mm or more and 8 mm or less, 3 mm or more and 7 mm or less, 3 mm or more and 5 mm or less, or 2 mm or more and 4 mm or less. Examples of the flow path 3 are artificial blood vessels and catheters.

[0035] Housing 7

[0036] The housing 7 is an element for accommodating the membrane 5 inside. The housing can be the main body of a medical device having a membrane inside. An example of the housing is a hexagonal columnar main body in a blood filtration device (Japanese Patent Publication No. 2017-158814). The housing 7 has a membrane 5 inside, so it plays a function as a filtering device, for example. An example of the membrane 5 can be a planar membrane or a hollow fiber membrane. The membrane 5 can be a planar membrane or a plurality of membranes can be stacked. The membrane 5 inside the housing 7 is a case where a plurality of membranes are stacked, and sometimes a connector 21 exists between the membranes. Moreover, in the case where a plurality of membranes are stacked, there is an inter-membrane flow path 17 through which a liquid to be filtered flows between the membranes. An example of the membrane 5 is a hemodiafiltration membrane. The pore size of the hemodiafiltration membrane is preferably above 0.1nm and below 10nm, and can also be above 0.5nm and below 2nm. If it is of this size, viruses and bacteria cannot pass through, so even if viruses and bacteria are mixed, they will not be mixed into the blood, so infections can be prevented.

[0037] Inner cavity 9

[0038] The inner cavity 9 refers to the space (area) inside the main body 11 of the connecting device 1. The main body 11 of the connecting device 1 is a frame (outer box) inside which the inner cavity 9 exists. The connecting device 1 is a device for connecting the flow path 3 to the housing 7 in a state in which liquid can be transported. For example, the cross-sectional area of ​​the inner cavity (the area through which liquid passes) at the end of the flow path 3 connected to the connecting device 1 is sometimes smaller than the inner cavity (the area through which liquid passes) at the end of the housing 7 connected to the connecting device 1. Therefore, the flow path 3 cannot be directly connected to the housing 7. The inner cavity 9 of the connecting device 1 has a first end that is suitable for the shape of the end of the flow path 3 and a second end that is suitable for the end of the housing 7. "Suitable" here means physically connected in a manner that allows the liquid to be transmitted without leakage or stagnation. Therefore, by using the connecting device 1, the flow path 3 can be connected to the housing 7, and since the shape of the inner cavity 9 is smooth, the situation of stagnation of liquid flow can be reduced. An example of the shape of the inner cavity 9 is to have: an inlet portion, which is continuous from the first end and is suitable for the inner cavity shape of the end of the flow path 3; an outlet portion, which is continuous to the second end and is suitable for the inner cavity shape of the end of the shell 7; and a connecting portion, which smoothly connects the inlet portion and the outlet portion.

[0039] As described above, when the cross-sectional area of ​​the inner cavity at the end of the housing 7 is larger than the cross-sectional area of ​​the inner cavity at the end of the flow path 3, the inner cavity 9 preferably has a portion whose cross-sectional area increases from the end of the flow path 3 toward the end of the housing side. The outer wall portion of the inner cavity 9 preferably has a shape whose cross-sectional area gradually increases from the end of the flow path 3 toward the end of the housing side. In particular, in order to make the liquid flow without stagnation, the cross-sectional shape of the inner cavity portion of the flow path 3 is generally circular (including elliptical). On the other hand, in the case where the membrane 5 inside the housing 7 is formed by stacking multiple membranes, the shape of the inner cavity portion at the end of the housing 7 may be rectangular (square or quadrilateral). In this way, in the case where the shape of the inner cavity portion at the end of the flow path 3 is different from the shape of the inner cavity portion at the end of the housing 7, if the flow path 3 and the housing 7 are to be connected, the flow of the liquid may stagnate. By using this connecting device 1, the flow of the liquid can be smooth. For example, in the case where the liquid is blood, the stagnation of the liquid is the cause of thrombosis. By using the connection device 1, the blood flow can be smoothed and the occurrence of blood clots can be effectively reduced.

[0040] Flow path adjustment wall 13

[0041] The flow path adjustment wall 13 refers to a plurality of walls provided in the inner cavity 9. Between two adjacent flow path adjustment walls 13, an adjustment inter-wall flow path 15 is formed as a region where liquid flows. In addition, an adjustment inter-wall flow path 15 may also be formed between the outer wall of the inner cavity 9 and the flow path adjustment wall 13 located at the outermost side. In the case where the shape of the inner cavity 9 changes from the first end toward the second end, the flow velocity of the liquid flowing through the inner cavity 9 changes. It is desirable to minimize this change. The flow path adjustment wall 13 can suppress the change in the cross-sectional area of ​​the flow path. Furthermore, the adjustment inter-wall flow path 15 is formed by the flow path adjustment wall 13, so that the flow of the liquid can be smooth.

[0042] Figure 3 This is a conceptual diagram showing how liquid from the flow path is transferred to the membrane inside the housing via the inner cavity of the connecting device. Figure 3 (a) is a diagram for explaining the prior art. Figure 3 (b) is a diagram for explaining the present invention. In the case where the membrane 5 inside the housing 7 is formed by stacking a plurality of membranes, if the liquid collides with the connector 21, the flow of the liquid will stagnate. For example, if the fluid is blood, a thrombus may occur at the location where the fluid collides with the connector. Therefore, a preferred example of the flow path adjustment wall 13 is that the flow path adjustment wall 13 and the connector 21 are formed in a continuous manner. Therefore, since the inter-wall flow path 15 is connected to the inter-membrane flow path 17, the liquid flowing through the inner cavity 9 is smoothly transmitted to the plurality of stacked membranes 5. In addition, as Figure 3As shown in (b), in the case where the membrane 5 is formed on both sides of the connector 21, the flow path adjustment wall 13 can also be formed in a continuous manner with the connector 21 and the membrane 5. In this way, even in the case where the thickness of the membrane 5 cannot be ignored, the flow of the liquid can be smooth. In addition, it shows the case where the liquid from the flow path is transmitted to the membrane inside the shell via the inner cavity of the connecting device. On the other hand, even when the flow path for liquid discharge is connected from the inside of the shell, this connecting device can be preferably used. However, the flow rate and the condition of the liquid are different in the case where the liquid from the flow path is transmitted to the membrane inside the shell via the inner cavity of the connecting device and the case where the liquid from the shell is transmitted to the flow path for liquid discharge via the connecting device. Therefore, considering these conditions, it is preferred to design the adjustment wall flow path 15.

[0043] In the case where the inner cavity 9 has an introduction part, a connection part and an outlet part, the flow path adjustment wall 13 is preferably provided at the connection part and the outlet part, or provided at the outlet part. By doing so, the situation where the cross-sectional area of ​​the part where the liquid flows changes sharply can be alleviated. The plurality of flow path adjustment walls 13 are preferably arranged in parallel. Since the plurality of flow path adjustment walls 13 are arranged in parallel, the flow path 15 between the adjustment walls has a straight part, which promotes the flow of the liquid.

[0044] The flow path regulating wall 13 may be formed by periodically arranged protrusions or may have a rib structure.

[0045] The next invention described in this specification relates to a method for manufacturing the above-mentioned connection device 1.

[0046] This method includes a step of providing a virtual flow path layer, a step of forming a flow path adjustment wall, and a step of obtaining a flow path between the adjustment walls.

[0047] Setting process of virtual flow path layer

[0048] The virtual flow path layer setting step is a step for setting a plurality of virtual flow path layers 23 having a thickness corresponding to the inter-membrane flow paths 17 formed by the plurality of laminated films 5 in the main body 11 of the connection device 1. The main body 11 of the connection device 1 is a housing (frame, outer box) in which the inner cavity 9 exists.

[0049] Figure 4 This is a conceptual diagram for explaining the process of setting up a virtual flow path layer. Figure 4 (a) is a diagram showing a case where a plurality of sheets are provided. Figure 4 (b) is a diagram showing a state where a plurality of sheets are put together. Figure 4 (c) is a diagram showing the case where the cover is installed. Figure 4As shown in (a), a plurality of thin sheets are provided at positions corresponding to between the connectors 21 and 21. In addition, when the housing and the connecting device 1 are integrally formed, a thin sheet is provided in the inter-membrane flow path 17 between the connectors 21 and 21. This thin sheet later becomes the adjustment inter-wall flow path 15. Therefore, the size and thickness of the thin sheet can be adjusted by matching the inter-membrane flow path 17 and the adjustment inter-wall flow path 15. Next, as Figure 4 As shown in (b), a plurality of sheets are brought together by a connecting portion 25. This connecting portion 25 is an element that becomes a part of the connecting device 1, and may also be a joint portion with the flow path 3. Figure 4 As shown in (c), a cover is provided to form a region corresponding to the main body of the connection device. Thus, a virtual flow path layer 23 is formed in the region that becomes the connection device.

[0050] Flow path adjustment wall forming process

[0051] The flow path regulating wall forming step is a step for forming a plurality of flow path regulating walls 13 between a plurality of virtual flow path layers 23 . Figure 5 This is a conceptual diagram for explaining the process of forming the flow path regulating wall. Figure 5 (a) is a diagram showing a state where a resin is put into a cap. Figure 5 (b) is a diagram showing the state of curing the resin. Figure 5 As shown in (a), resin is placed inside the cover. Figure 5 As shown in (b), the resin is hardened. Thus, a plurality of flow path adjustment walls 13 are formed between the plurality of imaginary flow path layers 23. Such resins are known. When forming the flow path adjustment walls 13 by this method, thermosetting resins and photocuring resins can be preferably used. Thermosetting resins and photocuring resins are known. Examples of thermosetting resins are epoxy compounds containing aromatic groups that are thermally stable at high temperatures. Photocuring resins can also be obtained by adding a photoacid generator to the thermosetting resin. Examples of photoacid generators are SbF 6 -PF 6 -、BF 4 - and AsF 6 - The content of the photoacid generator is in the range of 0.5 to 2.0 parts by mass based on 100 parts by mass of the thermosetting resin. When a photocurable resin is used, it is preferred that the cover has a light-transmitting property such as being transparent.

[0052] Adjustment of the inter-wall flow path acquisition process

[0053] The inter-adjustment-wall flow path obtaining step is a step for removing the virtual flow path layer 23 after forming a plurality of flow path adjusting walls 13 to obtain the inter-adjustment-wall flow paths 15 formed by the plurality of flow path adjusting walls 13 .

[0054] Figure 6 It is a diagram for explaining the process of adjusting the inter-wall flow path acquisition. Figure 6 (a) is a conceptual diagram showing a situation when the virtual flow path layer is removed. Figure 6 (b) is a diagram showing a state where the cover is removed to obtain a connection device. The cover is removed while removing the virtual flow path layer 23. When the virtual flow path layer 23 is removed, the adjustment inter-wall flow path 15 is formed in its place. Figure 6 (a) is a conceptual diagram showing the situation when the virtual flow path layer is removed. In addition, the cover can also be removed before removing the virtual flow path layer. Figure 6 As shown in (b), in the case where the connecting device 1 is not integrally formed with the shell 7, the position corresponding to the film 5 can be removed. In this way, a connecting device can be obtained. The connecting device is preferably formed as a whole with the shell 7 and the film 5 inside thereof. By integrally forming the connecting device with the shell 7 and the film 5 inside thereof, the interfaces between the parts that usually need to be prevented from leaking, such as gaskets, are eliminated. The above is explained with the film 5 being a laminated type as the center. On the other hand, in the case where the film 5 is a hollow wire, a rod-shaped body with the same diameter as the hollow wire is used, and the connecting device can be manufactured in the same manner as the film 5 is a laminated type.

[0055] The above description is directed to a method for manufacturing a connection device using the housing 7 having a plurality of laminated films 5. On the other hand, the connection device may be manufactured together with the housing 7.

[0056] The liquid from the flow path 3 is transferred to the housing 7 through the inner cavity 9 of the connecting device 1. The connecting device 1 has a plurality of flow path adjustment walls 13 provided in the inner cavity 9. The housing 7 accommodates the membrane 5. Therefore, the liquid from the flow path 3 is transferred to the membrane 5 in the housing 7 through the adjustment wall flow path 15 formed by the flow path adjustment walls 13 present in the inner cavity 9 of the connecting device 1.

[0057] Blood filtration device

[0058] Figure 7 : is an exploded view of a blood filtration device. In this example, the flow path 3 is an artificial blood vessel. The artificial blood vessel is connected to a blood vessel of a living body, for example. In this example, a connecting device 1 is connected to an arterial port and a venous port. A membrane 5 is present between the blood flow path layer and the filtrate flow path layer. In this example, a combination of multiple layers of blood flow path layers, membranes 5, and filtrate flow path layers is stacked. The filtrate is discharged from the filtrate tube.

[0059] The blood flow path layer preferably has a plate-like main body, a groove (incision) formed in the plate-like main body and used to form the blood flow path, and a resin layer formed on the side wall of the groove. In this way, since the plate-like main body does not contact the blood, the choice of the material of the plate-like main body can be expanded. The resin layer is thicker at the bottom and the top compared to the center in the height direction of the side wall of the groove, and preferably has a shape with a thickness that changes smoothly. If it has such a shape, it can effectively prevent the situation where there is a thrombus in the blood flow path. This structure can be used in implantable artificial kidneys, portable artificial kidneys, hemodialyzers, blood filters or extracorporeal membrane oxygenation.

[0060] Example

[0061] A PTFE sheet having a width of 2 mm and a length of 40 mm or more is cut out from the PTFE sheet.

[0062] A prescribed number of PTFE sheets are inserted from the circular end side of the connecting component. In this embodiment, there are 4 PTFE sheets (0.3×2.0 mm). Therefore, the stacked cross-section of the PTFE sheets is 1.2×2.0 mm, which is consistent with the size of the rectangular cross-section of the connecting component. At this time, the diagonal length of the rectangular cross-section of the connecting component is preferably designed to be equivalent to the diameter of the circular end face of the connecting component. With such a design, the cross-sectional area is always fixed, so the flow rate will not drop, which is beneficial to anti-thrombotic properties.

[0063] Insert the tip of the PTFE sheet into each inlet of the laminated filter. The insertion length is about 5 mm.

[0064] The connecting member is then fixed to the laminated filter. In the case of the connecting member being PMMA, blood compatibility is poor, so an internal coating and anti-thrombotic treatment are performed in advance.

[0065] UV curing adhesive 4305 (high viscosity type) was dripped into the PTFE sheet portion between the connecting component and the laminated filter, and a UV exposure machine (14±4W / m 2 ) for more than 180 seconds to cure the UV curing adhesive. This operation can also be divided into multiple times.

[0066] After the PTFE sheets in the gaps are completely covered, the ribs are externally fixed to the laminated filter.

[0067] Fill the inside with UV curable adhesive 4304 to fill the outer packaging, and use a UV exposure machine (14±4W / m 2) for more than 300 seconds to harden it. If all is filled at once, bubbles will be generated inside due to the shrinkage of the resin during the action, so it is preferably divided into multiple times. Since the substance filled inside does not come into contact with blood and there is no need to select the material, silicone resin such as PDMS can be used. However, when silicone resin is used to fill the inside, it is preferably left at room temperature for more than 48 hours until the silicone resin hardens.

[0068] After all hardening work is completed, pull out the PTFE sheet from the connecting parts using small tweezers or tweezers, etc.

[0069] Figure 8 This is a photograph replacing the drawing showing the connection device obtained in the embodiment. In this example, the connection device is integrally formed with the housing. Fig. 9 A photograph is provided to replace a drawing showing an example of use of the connection device. Fig. 9 (a) shows the situation when the connection device without the flow path adjustment wall is used. Fig. 9 As shown in (a), if there is no flow path regulating wall, thrombus will occur. Fig. 9 (b) shows an example of using a connection device provided with a flow path adjustment wall. Fig. 9 As shown in (b), by providing a flow path adjustment wall, even if the connection device is used for a long time, the blood flow does not change and thrombosis does not occur.

[0070] The present invention can be utilized in the field of medical equipment, for example.

[0071] Description of Reference Numerals

[0072] 1: Connecting device

[0073] 3: Flow path

[0074] 5: Membrane

[0075] 7: Shell

[0076] 9: Inner cavity

[0077] 13: Flow path adjustment wall

[0078] 15: Adjust the inter-wall flow path

[0079] 17: Intermembrane flow path

[0080] 23: Hypothetical flow path layer

Claims

1. A connection device (1), characterized in that: It has an inner cavity (9) for connecting the flow path (3) to the housing (7) containing the membrane (5) in a state capable of conveying liquid; The connecting device (1) has a plurality of flow path adjustment walls (13) arranged in the inner cavity (9); The film (5) is a plurality of laminated films; The inter-adjustment wall flow paths (15) formed by the plurality of flow path adjustment walls (13) correspond to the inter-membrane flow paths (17) formed by the plurality of laminated films (5); When the housing (7) is connected to the connecting device (1), the adjustment inter-wall flow path (15) is connected to the inter-membrane flow path (17).

2. The connection device (1) according to claim 1, characterized in that The housing (7) comprises connectors (21) present at the ends of the plurality of membranes (5); When the housing (7) is connected to the connection device (1), each of the plurality of flow path adjustment walls (13) is connected to the connector (21).

3. The connection device (1) according to claim 1, characterized in that The plurality of flow path adjustment walls (13) are arranged in parallel.

4. The connection device (1) according to claim 1, characterized in that The inner cavity (9) has a portion whose cross-sectional area increases from the end of the flow path (3) toward the end on the housing side.

5. A blood filtration device, characterized in that: It comprises the connecting device (1) as claimed in claim 1.

6. A method for manufacturing a connecting device (1), characterized in that: The connecting device (1) has an inner cavity (9) for connecting the flow path (3) to a housing (7) containing a plurality of laminated membranes (5) in a state capable of conveying liquid; The inner cavity (9) is a space formed inside the main body (11) of the connecting device (1); The manufacturing method of the connecting device (1) comprises: When manufacturing the connection device (1), a process is provided in which a plurality of imaginary flow path layers (23) having a thickness corresponding to the inter-membrane flow paths (17) formed by the plurality of laminated films (5) are provided inside a portion to be the main body (11); A step of forming a plurality of flow path adjustment walls (13) between the plurality of virtual flow path layers (23); as well as After forming the plurality of flow path adjustment walls (13), removing the imaginary flow path layer (23) to obtain an adjustment wall flow path (15) formed by the plurality of flow path adjustment walls (13); The adjustment inter-wall flow path (15) corresponds to the inter-membrane flow path (17); When the housing (7) is connected to the connecting device (1), the adjustment inter-wall flow path (15) is connected to the inter-membrane flow path (17).

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