Minimally invasive biopsy and anesthesia integrated device for abdominal wall adipose tissue and using method and application of minimally invasive biopsy and anesthesia integrated device

Abstract

The invention relates to an abdominal wall fat tissue minimally invasive biopsy and anesthesia integrated device and a using method and application thereof.The device comprises an anesthesia injection and fat sampling integrated sterile needle, the anesthesia injection and fat sampling integrated sterile needle comprises a puncture needle, a needle head connecting part, a compressible cavity and a pressing head which are sequentially connected, and the pressing head is provided with a connecting hole communicated with the compressible cavity; a detachable sealing piece is arranged at the top of the connecting hole, anesthesia injection is contained in the compressible cavity, and a sealing cover arranged on the outer side of an opening of the puncture needle in a sleeving mode is arranged at the bottom of the puncture needle. The device further comprises a surface anesthesia application, a miniature negative pressure pump, tweezers, a sample split charging small tube and a disinfection cotton swab. According to the device, the surface anesthesia application, the anesthesia injection and fat sampling integrated sterile needle are matched for use, so that the preparation is simple, and the fat tissue collection step is simplified; the related biopsy method adopts a minimally invasive technology, so that tissue damage and postoperative recovery time are reduced; the device can also be integrated into a kit for direct detection of adipose tissue.

Description

Technical Field

[0001] The present invention relates to the technical field of medical instruments, and in particular to an integrated device for minimally invasive biopsy and anesthesia of abdominal wall fat tissue, and a use method and application thereof. Background Art

[0002] Tissue puncture biopsy technology refers to the use of a hollow puncture needle to take part of the living diseased tissue for pathological examination. It is often used for the diagnosis and evaluation of superficial tumors, lymph nodes, thyroid, liver, lung, breast, and kidney lesions. The puncture biopsy has the advantages of less damage, fast recovery, and clear diagnosis. The puncture biopsy needle is a medical device used for sampling and aspirating cells from cone tumors and unknown tumors in various organs such as the kidney, liver, lung, breast, thyroid, prostate, pancreas, testicle, uterus, ovary, and body surface. So far, traditional tissue biopsy needles are mainly used for puncture biopsy of the breast, thyroid, muscle, lung and liver, but they are usually not suitable for adipose tissue. In clinical practice, the technology of puncture biopsy of adipose tissue is rarely used in obesity-related diagnosis and treatment.

[0003] Although the prior art also has puncture needles that can be used for fat tissue biopsy, for example: Chinese patent CN115192090A discloses a single-insertion multi-sample biopsy device, which includes a driver assembly that needs to be powered on and a biopsy probe assembly (including a sample groove and a cutter sleeve), which can promote the effective cutting of tissue samples and effectively transport tissue samples to a sample collection container; Chinese patent CN117838202A discloses an abdominal wall fat biopsy device, which dynamically adjusts the negative pressure suction of the syringe through a ratchet mechanism to achieve rapid extraction of fat tissue and improve extraction efficiency; Chinese patent CN213551989U discloses a single-insertion multi-sample biopsy device, which includes a driver assembly that needs to be powered on and a biopsy probe assembly (including a sample groove and a cutter sleeve), which can promote ... a single-insertion multi-sample biopsy device, which dynamically adjusts the negative pressure suction of the syringe through a ratchet mechanism to achieve rapid extraction of fat tissue and improve extraction efficiency; Chinese patent CN213551989U discloses a single-insertion multi-sample biopsy device, which includes a single-insertion multi-sample biopsy device, which includes a single-insertion multi-sample biopsy device, and a single-insertion multi-sample biopsy device, which includes a single-insertion multi-sample biopsy A new type of fat biopsy needle has been developed, which includes a syringe, a push rod and a support column. The space in the syringe is divided into a front end for holding fat tissue and a rear end for the push rod to move, so as to solve the problem that fat specimens in traditional fat biopsy needles are difficult to remove, difficult to recycle and easy to be damaged; the support column can abut against the tail wing at the end of the push rod to ensure the negative pressure state inside the syringe; and the relevant technical literature also discloses that subcutaneous fat samples can be obtained safely and effectively in a non-clinical environment, using a 14G needle of a 5 or 10mL syringe, and adipose tissue fragments are sucked into the syringe through the needle, and about 200 mg of tissue can be collected in one biopsy. However, the components and operation methods of the above-mentioned fat tissue puncture needle still have the following problems: 1) The operator needs to perform a separate local anesthesia operation before using the components, which increases the operation steps of fat biopsy, and anesthetic drugs and syringes need to be prepared separately; 2) The component aspirates the tissue operation process is still cumbersome and the steps are complicated; 3) The local anesthesia before the fat puncture biopsy step requires the operator to be a medical staff, familiar with the steps of local anesthesia, and the puncture process itself still has high requirements for the operator's clinical medical expertise. Summary of the invention

[0004] In order to overcome at least one problem existing in the prior art, the present invention optimizes the design of an integrated sterile needle for anesthesia injection and fat sampling, and manufactures it together with other necessary components into an integrated anesthesia device for minimally invasive biopsy of abdominal wall fat tissue. The above-mentioned device is suitable for the collection of fat tissue, and can be placed in a detection kit for application in fields related to obesity prevention and treatment; the above-mentioned device adopts an integrated anesthesia biopsy needle, which effectively simplifies the operation steps, is easy to operate, and reduces the technical requirements for the operator to a certain extent.

[0005] To achieve the above object, the present invention adopts the following technical solution:

[0006] The first aspect of the present invention is to provide an integrated anesthesia device for minimally invasive biopsy of abdominal wall fat tissue, which includes an integrated sterile needle for anesthesia injection and fat sampling. The integrated sterile needle for anesthesia injection and fat sampling includes a puncture needle, a needle connection part, a compressible cavity, and a pressing head connected in sequence. The pressing head has a connecting hole connected to the compressible cavity, a detachable sealing part is arranged on the top of the connecting hole, the compressible cavity contains an anesthetic injection solution, and the bottom of the puncture needle is provided with a sealing cover which is sleeved on the outside of its opening.

[0007] In some of the embodiments, the compressible cavity is made of soft plastic, which can empty the liquid inside it under compression; the needle connecting part and the pressing head are made of hard plastic that is not easily deformed, so as to fix the puncture needle and the compressible cavity respectively.

[0008] In some embodiments, the top of the connecting hole is flush with the top of the pressing head, and the inside of the connecting hole is provided with threads. In some alternative embodiments, the top of the connecting hole protrudes from the top of the pressing head, and the outside or inside of the connecting hole is provided with threads.

[0009] In some of the embodiments, the sealing member is a sealing plug or a sealing membrane.

[0010] In some of the embodiments, a fine hole is provided at the bottom of the puncture needle, and a sealing ring is sleeved outside the fine hole.

[0011] In some embodiments, the needle connecting portion is externally fixed with an auxiliary pressing portion.

[0012] In some of the embodiments, a plurality of push position icons are marked on the upper middle portion of the puncture needle, which are push position icons for the puncture needle set according to the patient's body shape.

[0013] In some of these embodiments, the device further comprises a topical anesthetic patch.

[0014] In some of the embodiments, the surface anesthesia patch includes an upper film layer, an intermediate medium layer, and a lower film layer arranged in sequence, the intermediate medium layer is an anesthetic cream located in the central part and fixed to the bottom of the upper film layer, and the lower film layer is fixed to the bottom of the upper film layer by an adhesive tape.

[0015] In some of the embodiments, the upper film layer is a highly breathable sterile non-woven fabric, the middle medium layer is a sterile non-woven cotton that absorbs the anesthetic cream, and the lower film layer is a plastic film.

[0016] In some of the embodiments, the device further comprises a micro negative pressure pump.

[0017] In some of the embodiments, the micro negative pressure pump is a medical rechargeable / battery-type negative pressure suction motor head, which is provided with a suction nozzle and an exhaust nozzle, and can continuously form a vacuum or negative pressure at the inlet and a slight positive pressure at the exhaust nozzle. The adjustment range of the above-mentioned micro negative pressure pump is 0mmHg to -100mmHg.

[0018] In some embodiments, the suction nozzle of the micro negative pressure pump is connected to the connecting hole through a thread, so that it is connected to the compressible cavity. When the micro negative pressure pump is started, a vacuum or negative pressure is formed inside the compressible cavity.

[0019] In some of the embodiments, the device further comprises tweezers, a sample dispensing tube, and a sterile cotton swab.

[0020] In some embodiments, the tweezers are disposable sterile plastic tweezers, and the sterile cotton swab is a sterile cotton swab with iodine.

[0021] The second part of the present invention is to provide a method for using any one of the abdominal wall fat tissue minimally invasive biopsy anesthesia integrated devices described in the first aspect, comprising the steps of:

[0022] Step S1, using a sterile cotton swab to sterilize the skin surface of the puncture site; preferably, the number of sterilizations is 2 times.

[0023] Step S2, tear off the lower film layer of the surface anesthesia dressing, and apply the anesthetic cream in the surface anesthesia dressing to the disinfected skin; the application time is preferably at least 20 minutes.

[0024] Step S3, after the surface anesthesia is completed and the positioning is confirmed again, the sealing cover at the bottom of the puncture needle is removed, and the needle is inserted into the surface anesthesia patch and the skin; during the puncture process, the anesthetic injection liquid in the compressible cavity can smoothly penetrate into the tissues around the puncture point from all layers through the bottom of the puncture needle to perform local anesthesia;

[0025] Step S4: after local anesthesia is completed, remove the seal at the top of the connecting hole in the pressing head, and connect the suction nozzle of the micro negative pressure pump to the connecting hole;

[0026] Step S5, starting the micro negative pressure pump, and the subcutaneous fat tissue can smoothly enter the emptied compressible cavity through the puncture needle;

[0027] Step S6: After the fat tissue is collected, slowly pull the puncture needle out of the skin, and use tweezers to pack the obtained fat tissue into sample packing tubes; at this time, the surface anesthesia dressing is used as a band-aid and kept attached to the puncture site of the skin.

[0028] The third aspect of the present invention is to provide a use of any one of the abdominal wall fat tissue minimally invasive biopsy and anesthesia integrated devices described in the first aspect in the preparation of a fat tissue detection kit.

[0029] In some embodiments, the kit is used to detect adipose tissue lipid metabolites or metabolic health-related genes.

[0030] In some of the embodiments, the above-mentioned kit can be used for screening drugs in the field of obesity prevention and treatment, etc.

[0031] Compared with the prior art, the present invention adopts the above technical solution to have the following beneficial effects:

[0032] The present invention has developed an integrated device for pressing and aspirating abdominal wall fat tissue for fat tissue biopsy. The biopsy needle used in the device is specially designed for abdominal wall fat tissue, allowing safe and accurate fat tissue collection under local anesthesia. The above-mentioned biopsy needle reduces the postoperative recovery time and the risk of complications through minimally invasive technology, allowing doctors to perform the procedure quickly in an outpatient environment.

[0033] The integrated device for minimally invasive biopsy and anesthesia of abdominal wall fat tissue designed by the present invention has the following advantages: (1) The integrated design of surface anesthesia, local anesthesia and fat biopsy puncture uses a surface anesthesia patch, anesthesia injection and fat sampling integrated sterile needle in combination, which reduces the number of conventional anesthesia supplies such as medicines and syringes prepared during the entire puncture process, and simplifies the disinfection and anesthesia steps before puncture and the bandaging steps after puncture; (2) The integrated sterile needle for anesthesia injection and fat sampling of the present invention is easy to operate, and does not require the operator to master local anesthesia skills, and even non-medical professionals can operate it; (3) The fat tissue collection steps of the present invention are simplified, and the preparation is simple, which is convenient for use in outpatient clinics and not very complex medical environments, and does not require any other items; the biopsy method of the present invention adopts minimally invasive technology, which reduces tissue damage and postoperative recovery time; and can accurately sample to ensure that sufficient and high-quality fat tissue samples are obtained; (4) The supporting device of the present invention has broad application potential and can be used for routine clinical diagnosis and treatment, and has broad application prospects in obesity prevention and treatment. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] The drawings described herein are used to provide a further understanding of the present invention and constitute a part of the present invention. The exemplary embodiments of the present invention and their descriptions are only used to explain the present invention and do not constitute an improper limitation of the present invention. In the drawings:

[0035] Figure 1 is a schematic diagram of an integrated sterile needle for anesthesia injection and fat sampling in one embodiment of the present invention;

[0036] Figure 2 yes Figure 1 A schematic cross-sectional view of an integrated sterile needle for anesthesia injection and fat sampling is shown;

[0037] Figure 3 is a schematic diagram of a surface anesthesia dressing according to an embodiment of the present invention;

[0038] Figure 4 yes Figure 3 A schematic cross-sectional view of a topical anesthesia dressing is shown;

[0039] Figure 5 This is a schematic diagram of the operation steps of the integrated device for minimally invasive biopsy and anesthesia of abdominal wall fat tissue in one embodiment of the present invention;

[0040] Figure 6 is an optimized schematic diagram of a puncture needle in one embodiment of the present invention;

[0041] Figure 7 is an optimized schematic diagram of a needle connection portion in one embodiment of the present invention;

[0042] The accompanying drawings are marked as follows: 1-integrated sterile needle for anesthesia injection and fat sampling; 11-compressible cavity; 111-anesthetic injection solution; 12-pressing head; 13-connecting hole; 14-sealing piece; 15-needle connecting part; 151-auxiliary pressing part; 16-puncture needle; 161-fine hole; 162-sealing ring; 17-sealing cover; 2-surface anesthesia dressing; 21-lower film layer; 22-middle medium layer; 23-upper film layer; 3-skin; 4-micro negative pressure pump; 5-tweezers; 6-sample dispensing tube; 7-sterile cotton swab; 8-fat tissue. DETAILED DESCRIPTION

[0043] In order to make the purpose, technical solutions and advantages of the present application more clearly understood, the present application is described and illustrated below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and are not intended to limit the present application. Based on the embodiments provided in the present application, all other embodiments obtained by ordinary technicians in the field without making creative work are within the scope of protection of the present application.

[0044] Obviously, the drawings described below are only some examples or embodiments of the present application. For ordinary technicians in this field, the present application can also be applied to other similar scenarios based on these drawings without creative work. In addition, it can also be understood that although the efforts made in this development process may be complicated and lengthy, for ordinary technicians in this field related to the content disclosed in this application, some changes in design, manufacturing or production based on the technical content disclosed in this application are just conventional technical means, and should not be understood as insufficient content disclosed in this application.

[0045] Reference to "embodiments" in this application means that a particular feature, structure, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those of ordinary skill in the art that the embodiments described in this application may be combined with other embodiments without conflict.

[0046] Unless otherwise defined, the technical terms or scientific terms involved in this application should be understood by people with ordinary skills in the technical field to which this application belongs. The words "one", "a", "a", "the" and the like involved in this application do not indicate a quantitative limitation, and may represent the singular or plural. The terms "include", "comprise", "have" and any of their variations involved in this application are intended to cover non-exclusive inclusions; for example, a process, method, system, product or device that includes a series of steps or modules (units) is not limited to the listed steps or units, but may also include steps or units that are not listed, or may also include other steps or units inherent to these processes, methods, products or devices. The words "connect", "connected", "coupled" and the like involved in this application are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. The "multiple" involved in this application refers to two or more. "And / or" describes the association relationship of associated objects, indicating that there may be three relationships, for example, "A and / or B" can represent: A exists alone, A and B exist at the same time, and B exists alone. The character " / " generally indicates that the objects before and after are in an "or" relationship. The terms "first", "second", "third", etc. involved in this application are only used to distinguish similar objects and do not represent a specific ordering of the objects.

[0047] It should be noted that, in the absence of conflict, the embodiments of the present invention and the features in the embodiments can be combined with each other. The present invention is further described below in conjunction with the drawings and specific embodiments, but is not intended to be a limitation of the present invention.

[0048] Example 1 - Anesthesia injection and fat sampling integrated sterile needle

[0049] This embodiment is an illustrative embodiment of an integrated sterile needle for anesthesia injection and fat sampling.

[0050] like Figure 1 and Figure 2As shown, the various components of the above-mentioned integrated sterile needle 1 for anesthesia injection and fat sampling are generally cylindrical with a hollow interior, which includes a puncture needle 16, a needle connector 15, a compressible cavity 11 (its exterior is similar to a plurality of superimposed rings, and its interior is hollow, with good compressibility), and a pressing head 12 connected in sequence; wherein, the compressible cavity 11 is made of soft plastic, which can empty its internal liquid under compression; the needle connector 15 and the pressing head 12 are made of hard plastic that is not easily deformed, so as to fix the puncture needle 16 and the compressible cavity 11 respectively; the needle connector 15, the compressible cavity 11, and the pressing head 12 are integrally formed components, and their materials are all conventionally used materials in this field. The central bottom of the needle connector 15 is connected to the top of the puncture needle 16, and its connection method refers to the conventional injection syringe in this field. The bottom of the puncture needle 16 is a conventional tip needle shape with an opening to facilitate the rapid insertion of the puncture needle.

[0051] like Figure 2 As shown, a connecting hole 13 communicating with the compressible cavity 11 is provided at the central portion of the pressing head 12, and a detachable sealing member 14 (specifically, a rubber sealing plug, a sealing sheet made of aluminum foil, or a sealing film made of plastic) is provided at the top of the connecting hole 13. The compressible cavity 11 contains a predetermined amount of anesthetic injection solution 111 (for local anesthesia) in the initial state. A sealing cover 17 is provided at the bottom of the puncture needle 16 and is sleeved on the outside of the opening thereof, so as to close the opening at the bottom of the puncturer, thereby preventing leakage of the anesthetic injection solution 111 in the compressible cavity 11 in the initial state.

[0052] In some alternative embodiments, such as Figure 6 As shown, a fine hole 161 is provided at the bottom of the puncture needle 16, and a sealing ring 162 is sleeved on the outside of the fine hole 161. At this time, an opening is provided or not provided at the bottom of the puncture needle 16. The cooperation between the fine hole 161 and the bottom opening can make the anesthetic injection liquid penetrate into the surrounding tissues of the puncture site at multiple points at different positions, which is more conducive to local anesthesia.

[0053] like Figure 2 As shown, the top of the connecting hole 13 located at the center of the pressing head 12 is flush with the top of the pressing head 12, that is, it directly penetrates the pressing head 12 to achieve communication between the connecting hole 13 and the internal space of the compressible cavity 11. At this time, a thread is set inside the connecting hole 13 for connection with the negative pressure device.

[0054] In some alternative embodiments, such as Figure 7 As shown, the top of the connecting hole 13 protrudes from the top of the pressing head 12, that is, the connecting hole 13 is a circular hole channel that passes through the pressing head 12 and extends outward. A thread is arranged outside or inside the connecting hole 13. This design increases the convenience of operation when connecting an external negative pressure device.

[0055] In some alternative embodiments, such as Figure 7 As shown, an auxiliary pressing portion 151 is fixed to the outside of the needle connecting portion 16 (it can be a circular ring fixed to the outer periphery of the needle connecting portion 16, or it can be two pressing pieces fixed to the needle connecting portion 16 and symmetrically distributed). This design allows the puncture needle to be inserted into the skin first, and then the anesthetic injection solution is injected, which is conducive to the uniform injection of anesthetic.

[0056] In certain alternative embodiments, a plurality of push position icons (not shown in the figure) are marked on the upper portion of the puncture needle 16, which are the push depths of the puncture needle set according to the patient's body shape. For example, for patients with a thin body shape, the push depth is shallower, and for patients with an obese body shape, the push depth is deeper. The above-mentioned push position icons may take the form of a conventional scale.

[0057] The above-mentioned integrated sterile needle for anesthesia injection and fat sampling has built-in anesthetic injection solution, which does not require separate preparation of anesthetic drugs and syringes, simplifies the local anesthesia operation, is easy to operate, and does not require the operator to master local anesthesia skills. Even non-medical professionals can perform the operation.

[0058] Example 2 - Abdominal wall fat tissue minimally invasive biopsy anesthesia integrated device

[0059] This embodiment is a schematic embodiment of a preferred abdominal wall fat tissue minimally invasive biopsy anesthesia integrated device containing the anesthesia injection and fat sampling integrated sterile needle described in Example 1. Figure 5 As shown, the above-mentioned abdominal wall fat tissue minimally invasive biopsy anesthesia integrated device includes an anesthesia injection and fat sampling integrated sterile needle 1, a surface anesthesia patch 2, a micro negative pressure pump 4, tweezers 5, a sample dispensing tube 6, and a sterile cotton swab 7. The number of each of the above accessories can be 1 or more. The above-mentioned anesthesia injection and fat sampling integrated sterile needle 1 is used to achieve local anesthesia and the acquisition of fat tissue, the sterile cotton swab 7 (which can be an iodine-containing sterile cotton swab) is used to disinfect the puncture site, the above-mentioned surface anesthesia patch 2 is used to achieve the positioning of the puncture site and surface anesthesia, the above-mentioned micro negative pressure pump 4 cooperates with the anesthesia injection and fat sampling integrated sterile needle 1 to make the inside of the compressible cavity 11 a negative pressure state, and the above-mentioned tweezers 5 (which can be disposable sterile plastic tweezers) are used to take out the fat tissue in the compressible cavity 11 and dispense it into the sample dispensing tube 6.

[0060] like Figure 3 and Figure 4As shown, the surface anesthesia dressing 2 comprises an upper film layer 23, an intermediate medium layer 22, and a lower film layer 21 arranged in sequence, the intermediate medium layer 22 is an anesthetic cream located in the central part and fixed to the bottom of the upper film layer 23, and the lower film layer 21 is fixed to the bottom of the upper film layer 23 by an adhesive patch. The overall shape of the surface anesthesia dressing 2 can be a long strip, and the shape of the anesthetic cream is a disc or a long strip. The structure and material of the surface anesthesia dressing 2 are similar to those of the conventional band-aids used in the art. For example, the upper film layer 23 is a highly breathable sterile non-woven fabric, the intermediate medium layer 22 is a sterile non-woven cotton that absorbs drugs, and the lower film layer 21 is a plastic film, which only replaces the drugs in the band-aid with the anesthetic cream.

[0061] like Figure 5 As shown, the micro negative pressure pump 4 is provided with an air suction nozzle and an air exhaust nozzle, which can continuously form a vacuum or negative pressure at the inlet and a slight positive pressure at the air exhaust nozzle; the air suction nozzle of the micro negative pressure pump 4 is connected to the connecting hole 13 through a thread, so that it is connected to the compressible cavity 11. When the micro negative pressure pump 4 is started, a vacuum or negative pressure is formed inside the compressible cavity 11, so as to obtain fat tissue. The micro negative pressure pump 4 can be a conventional medical rechargeable / battery negative pressure suction motor head.

[0062] The above-mentioned abdominal wall fat tissue minimally invasive biopsy and anesthesia integrated device integrates surface anesthesia, local anesthesia, and fat biopsy puncture into one, reducing the conventional anesthetic supplies such as medicines and syringes prepared during the entire puncture process, and simplifying the disinfection and anesthesia steps before puncture and the bandaging steps after puncture. No other items are required when collecting fat tissue; the above-mentioned abdominal wall fat tissue minimally invasive biopsy and anesthesia integrated device can be integrated into a detection kit, and the collected fat tissue can be directly tested for the lipid metabolite content of the fat tissue or the expression of metabolic health-related genes after pretreatment, which is conducive to the determination of treatment plans for preventing and treating obesity.

[0063] Example 3 - Method for using the integrated anesthesia device for minimally invasive biopsy of abdominal wall fat tissue

[0064] This embodiment is a schematic embodiment of the operation method of the integrated device for minimally invasive biopsy and anesthesia of abdominal wall fat tissue described in Example 2. Figure 5 As shown, the method for using the above device specifically includes the steps of:

[0065] Step S1, using a sterile cotton swab 7 to sterilize the surface of the skin 3 at the puncture site twice;

[0066] Step S2, tear off the lower film layer 21 of the surface anesthesia dressing 2, and apply the anesthetic cream at the center of the surface anesthesia dressing 2 to the disinfected skin 3 to locally anesthetize the puncture site for at least 20 minutes;

[0067] Step S3, after the surface anesthesia is completed and the positioning is confirmed again, the sealing cover 17 at the bottom of the puncture needle 16 is removed and inserted into the surface anesthesia patch 2 and the skin 3; during the puncture process, the anesthetic injection solution 111 in the compressible cavity 11 can smoothly penetrate into the tissues around the puncture point from various layers through the bottom opening of the puncture needle 16 for local anesthesia.

[0068] The specific operation steps of the above step S3 are to slowly push the pressing head 12 with the thumb to make the puncture needle 16 enter the patient's subcutaneous tissue. According to the patient's body shape, estimate the patient's subcutaneous fat layer, and push the pressing head 12 to the estimated position. If this step involves Figure 6 and Figure 7 The operation steps can be adjusted to first slowly press the auxiliary pressing portion 151 with the thumb to insert the puncture needle 16 into the estimated position of the skin, and then slowly push the pressing head 12 with the thumb. At this time, if the puncture needle 16 is provided with a pore 161 and a sealing ring 162, the sealing ring 162 will move upward with the insertion of the puncture needle 16 to expose the pore 161.

[0069] Step S4, after local anesthesia is completed, remove the seal 14 at the top of the connecting hole 13 in the pressing head 12, and rotate the suction nozzle of the micro negative pressure pump 4 through the thread to communicate with the connecting hole 13, so as to achieve communication with the compressible cavity 11;

[0070] Step S5, start the micro negative pressure pump 4 (the adjustment range is 0 mmHg to -100 mmHg), and the subcutaneous fat tissue 8 can smoothly enter the emptied compressible cavity 11 through the puncture needle 16 (the anesthetic injection and the fat tissue use the same container, which will not contaminate the fat tissue, because: first, the anesthetic injection and the container are sterile; second, the very small amount of residual anesthetic liquid will not interfere with the subsequent detection results of the fat tissue);

[0071] Step S6, after the collection of the fat tissue 8 is completed, the puncture needle 16 is slowly pulled out of the skin, and the obtained fat tissue 8 is divided into sample distribution tubes 6 using tweezers 5, and prepared for inspection after marking; at this time, the surface anesthesia dressing 2 is used as a Band-Aid and kept attached to the puncture site of the skin 3.

[0072] The above-mentioned abdominal wall fat tissue minimally invasive biopsy anesthesia integrated device is simple to use and easy to operate, which effectively reduces the technical requirements for operators and thus has wide application potential.

[0073] It can be seen from the above embodiments that the present invention has developed an integrated anesthesia device for minimally invasive biopsy of abdominal wall fat tissue by pressing and aspirating. The biopsy needle used in the device reduces the conventional anesthetic supplies such as medicines and syringes prepared during the entire puncture process, and simplifies the disinfection and anesthesia steps before puncture and the bandaging steps after puncture. The above integrated device does not require the operator to master local anesthesia skills, and even non-medical professionals can operate it. It can also safely and effectively obtain samples from fat tissue for use in obesity-related diagnosis and treatment. The integrated anesthesia biopsy needle of the present invention can reduce invasiveness and postoperative complications, provide accurate sampling, and allow it to be performed under outpatient conditions, making it more suitable for frequent clinical examinations.

[0074] The specific embodiments of the present invention are described in detail above, but they are only examples, and the present invention is not limited to the specific embodiments described above. For those skilled in the art, any equivalent modifications and substitutions made to the present invention are also within the scope of the present invention. Therefore, the equalization changes and modifications made without departing from the spirit and scope of the present invention should be included in the scope of the present invention.

Claims

1. A minimally invasive biopsy anesthesia device for abdominal wall fat tissue, characterized in that: The device includes an integrated sterile needle for anesthesia injection and fat sampling, which includes a puncture needle, a needle connection part, a compressible cavity, and a pressing head connected in sequence. The pressing head has a connecting hole connected to the compressible cavity, a detachable sealing part is arranged on the top of the connecting hole, the compressible cavity contains an anesthetic injection solution, and a sealing cover is arranged on the bottom of the puncture needle and is sleeved on the outside of its opening.

2. The abdominal wall fat tissue minimally invasive biopsy anesthesia integrated device according to claim 1, characterized in that: The compressible cavity is made of soft plastic, which can empty the liquid inside it under compression; the needle connecting part and the pressing head are made of hard plastic that is not easily deformed, so as to fix the puncture needle and the compressible cavity respectively.

3. The abdominal wall fat tissue minimally invasive biopsy anesthesia integrated device according to claim 1, characterized in that: The top of the connecting hole is flush with the top of the pressing head, and a thread is arranged inside the connecting hole.

4. The abdominal wall fat tissue minimally invasive biopsy anesthesia integrated device according to claim 1, characterized in that: The device also includes a topical anesthetic dressing.

5. The abdominal wall fat tissue minimally invasive biopsy anesthesia integrated device according to claim 4, characterized in that: The surface anesthesia dressing includes an upper film layer, an intermediate medium layer, and a lower film layer arranged in sequence, wherein the intermediate medium layer is an anesthetic cream located in the central part and fixed to the bottom of the upper film layer, and the lower film layer is fixed to the bottom of the upper film layer by an adhesive patch.

6. The abdominal wall fat tissue minimally invasive biopsy anesthesia integrated device according to any one of claims 1 to 5, characterized in that: The device also includes a micro negative pressure pump.

7. The abdominal wall fat tissue minimally invasive biopsy anesthesia integrated device according to claim 6, characterized in that: The suction nozzle of the micro negative pressure pump is connected to the connecting hole through a thread, so that it is connected to the compressible cavity.

8. The abdominal wall fat tissue minimally invasive biopsy anesthesia integrated device according to claim 6, characterized in that: The device also includes tweezers, a sample dispensing tube, and a sterile cotton swab.

9. A method for using the abdominal wall fat tissue minimally invasive biopsy anesthesia integrated device as claimed in any one of claims 1 to 8, characterized in that: Includes steps: Step S1, using a sterile cotton swab to disinfect the skin surface of the puncture site; Step S2, tearing off the lower film layer of the surface anesthesia dressing, and applying the anesthetic cream in the surface anesthesia dressing to the disinfected skin; Step S3, after the surface anesthesia is completed and the positioning is confirmed again, the sealing cover at the bottom of the puncture needle is removed, and the needle is inserted into the surface anesthesia patch and the skin; during the puncture process, the anesthetic injection liquid in the compressible cavity can smoothly penetrate into the tissues around the puncture point from all layers through the bottom of the puncture needle to perform local anesthesia; Step S4: after local anesthesia is completed, remove the seal at the top of the connecting hole in the pressing head, and connect the suction nozzle of the micro negative pressure pump to the connecting hole; Step S5, starting the micro negative pressure pump, and the subcutaneous fat tissue can smoothly enter the emptied compressible cavity through the puncture needle; Step S6: After the fat tissue is collected, slowly pull the puncture needle out of the skin, and use tweezers to pack the obtained fat tissue into sample packing tubes; at this time, the surface anesthesia dressing is used as a band-aid and kept attached to the puncture site of the skin.

10. Use of the integrated device for minimally invasive biopsy and anesthesia of abdominal wall fat tissue as claimed in any one of claims 1 to 8 in preparing a fat tissue detection kit.

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