Moisturizing and moistening composition as well as preparation method and application thereof

Abstract

The invention relates to a moisturizing composition as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The moisturizing and moistening composition disclosed by the invention is prepared from the following components in parts by mass: 4.48 to 5.86 parts of a moisturizing agent, 2.236 to 4.612 parts of an emulsifying agent, 0.26 to 0.66 part of a skin softening and moistening agent, 0.052 to 0.292 part of a thickening agent, 0.052 to 0.292 part of an antioxidant synergist, 0.01 to 0.22 part of a preservative, 0.168 to 0.568 part of vitamin E, 0.04 to 0.4 part of cinnamon oil and 30.116 to 30.516 part of a solvent. The vitamin E and the cinnamon oil are selected to be combined with the moisturizer, the emulsifier, the skin softening agent, the thickening agent, the antioxidant synergist, the preservative and the water to form the moisturizing and nourishing composition, permeation of the vitamin E can be promoted, and the moisturizing and nourishing composition has the effects of moisturizing and nourishing for a long time, maintaining skin elasticity and repairing epidermis.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to a moisturizing composition and a preparation method and application thereof. Background Art

[0002] Hand cream is a cosmetic that can effectively prevent dry and chapped skin and make the skin delicate and smooth. Existing hand creams feel greasy when used, or have a short moisturizing time and insufficient moisturizing effect, and have no anti-itching and antibacterial ingredients. When itching occurs on the hands, it cannot be used anymore, or the anti-bacterial and anti-itching time is short. In addition, the cosmetic raw materials used in existing hand creams are conventionally selected by technicians in this field, and the antioxidant degree of conventional raw material combinations is relatively low. Vitamin E cannot penetrate well into the skin to achieve a long-lasting moisturizing effect on the skin. Summary of the invention

[0003] The purpose of the present invention is to overcome the shortcomings of the prior art and provide a vitamin E composition with good permeability, anti-oxidation, moisturizing and nourishing properties, as well as a preparation method and application thereof.

[0004] To achieve the above object, the technical solution adopted by the present invention is:

[0005] In a first aspect, the present invention provides a moisturizing composition, comprising the following components in parts by weight: 4.48-5.86 parts of a moisturizing agent, 2.236-4.612 parts of an emulsifier, 0.26-0.66 parts of a skin softener, 0.052-0.292 parts of a thickener, 0.052-0.292 parts of an antioxidant synergist, 0.01-0.22 parts of a preservative, 0.168-0.568 parts of vitamin E, 0.04-0.4 parts of cinnamon oil, and 30.116-30.516 parts of a solvent.

[0006] The present invention selects vitamin E and cinnamon oil and combines them with a moisturizer, an emulsifier, a skin softener, a thickener, an antioxidant synergist, a preservative and water to form a moisturizing composition, which can promote the penetration of vitamin E and has the effects of long-term moisturizing, maintaining skin elasticity and repairing the epidermis. At the same time, the moisturizing composition of the present invention also has excellent antioxidant effect, and can be used to prepare a hand cream, which brings long-term moisturizing and antioxidant effects to the hand cream, and the cinnamon oil itself has antibacterial, anti-inflammatory and antipruritic effects, which can improve the skin itching problem caused by dryness and other problems, and achieve a long-term soothing effect.

[0007] Cinnamon oil is a natural plant extract with strong antibacterial, anti-inflammatory and antipruritic effects. The cinnamaldehyde it contains is a natural antibacterial and anti-inflammatory ingredient, and is also a natural antioxidant that can reduce the production of free radicals and delay the aging process of the skin. In addition, as a natural penetration enhancer, it promotes the absorption of active ingredients such as squalane and vitamin E. It also has a special aroma and has the effect of regulating the smell of moisturizing and nourishing compositions.

[0008] Vitamin E is an antioxidant with anti-photoaging effects. It can protect skin cells from free radical damage, delay skin aging, promote skin metabolism, prevent pigmentation, maintain skin elasticity, reduce the formation of skin wrinkles, lock in skin moisture, and moisturize the skin for a long time. Vitamin E and cinnamon oil can improve the permeability of cinnamon oil and vitamin E. The two complement each other and synergistically increase the permeability of vitamin E, cinnamon oil and squalane in the moisturizing composition, achieving long-term moisturizing and anti-oxidation properties.

[0009] As a preferred embodiment of the moisturizing composition of the present invention, the moisturizing composition includes the following components in parts by mass: 5.26 parts of moisturizer, 3.412 parts of emulsifier, 0.46 parts of skin softener, 0.092 parts of thickener, 0.092 parts of antioxidant synergist, 0.02 parts of preservative, 0.368 parts of vitamin E, 0.4 parts of cinnamon oil and 30.316 parts of solvent. Under the preferred ratio, the present invention selects vitamin E and cinnamon oil and moisturizer, emulsifier, skin softener, thickener, antioxidant synergist, preservative and water to form a moisturizing composition. Through antioxidant tests and in vitro percutaneous penetration experiments, it is found that the moisturizing composition under the preferred ratio has a better antioxidant effect, and the penetration effect of vitamin E and cinnamaldehyde (the main active ingredient of cinnamon oil) is better.

[0010] As a preferred embodiment of the moisturizing composition of the present invention, the moisturizing agent includes at least one of liquid paraffin, squalane and glycerol; the mass ratio of the liquid paraffin, squalane and glycerol is liquid paraffin: squalane: glycerol = (0.808-1.308): (1.084-1.384): (2.568-2.968). Under the preferred mass ratio range, the inventors have experimentally confirmed that when the moisturizing agent is liquid paraffin, squalane and glycerol, the prepared moisturizing composition has better moisturizing and soothing effects.

[0011] The liquid paraffin selected in the present invention is cosmetic-grade liquid paraffin, which can increase the consistency and gloss of the moisturizing composition, is easy to spread and spread, and can also seal the moisture on the skin surface to prevent moisture evaporation and increase the moisturizing effect of the skin.

[0012] Squalane is an emollient and moisturizer that can effectively moisturize and protect the skin, prevent water loss, and promote natural skin repair and balance water and oil. In addition, squalane has excellent stability and non-sensitizing properties, and can reduce skin allergies while playing an antioxidant role.

[0013] Glycerin, as a humectant, can be added to the moisturizing composition to prevent the moisture in the skin from evaporating, allowing the moisture in the moisturizing composition to be absorbed by the skin, thereby maintaining the moisture and softness of the skin and reducing problems such as dry and cracked skin.

[0014] As a preferred embodiment of the moisturizing composition of the present invention, the mass ratio of liquid paraffin, squalane and glycerin in the moisturizing agent is liquid paraffin:squalane:glycerin=1.108:1.384:2.768.

[0015] As a preferred embodiment of the moisturizing composition of the present invention, the emulsifier includes at least one of glyceryl monostearate, glyceryl caprylate, stearic acid, triethanolamine, Tween 80 and Span 80; the mass ratio of glyceryl monostearate, glyceryl caprylate, stearic acid, triethanolamine, Tween 80 and Span 80 is glyceryl monostearate: glyceryl caprylate: stearic acid: triethanolamine: Tween 80: Span 80 = (1.084-1.584): (0.54-0.94): (0.084-0.384): (0.084-0.384): (0.444-0.844): (0.052-0.292). Within the preferred type and mass ratio range, the inventors have confirmed through experiments that when the emulsifier is glyceryl monostearate, caprylic decanoate, stearic acid, triethanolamine, Tween 80 and Span 80, the prepared moisturizing composition has better moisturizing and soothing effects.

[0016] As emulsifiers in the moisturizing composition, caprylic decanoic acid glyceryl and isopropyl palmitate can prevent the moisturizing composition from turning white when applied, and at the same time have moisturizing effects and enhance the gloss and elasticity of the skin. Stearic acid and glyceryl monostearate can ensure the uniformity and stability of the moisturizing composition, and at the same time improve the texture of the hand cream to make it smoother. Tween 80 and Span 80 have the effect of mixing the oily components and the aqueous components evenly, stabilizing the product properties, and increasing the ductility of the product. Triethanolamine can improve the stability of the moisturizing composition.

[0017] As a preferred embodiment of the moisturizing composition of the present invention, the mass ratio of glyceryl monostearate, caprylic decanoate, stearic acid, triethanolamine, Tween 80 and Span 80 in the emulsifier is glyceryl monostearate: caprylic decanoate: stearic acid: triethanolamine: Tween 80: Span 80 = 1.384:0.74:0.184:0.184:0.644:0.276.

[0018] As a preferred embodiment of the moisturizing composition of the present invention, the preservative is ethyl paraben; the antioxidant synergist is EDTA-2Na; the skin softener is isopropyl palmitate; and the thickener is carbomer 940. Carbomer 940, as a synthetic high molecular polymer, has a thickening effect, adjusts the viscosity of the hand cream, and moisturizes and relieves dry skin. EDTA-2Na has the effect of stabilizing the moisturizing composition.

[0019] As a preferred embodiment of the moisturizing composition of the present invention, the solvent is water.

[0020] In a second aspect, the present invention provides a method for preparing the above-mentioned moisturizing composition, comprising the following steps:

[0021] (1) heating liquid paraffin, glyceryl monostearate, caprylic decanoate, stearic acid, squalane, isopropyl palmitate, vitamin E and triethanolamine at 70-80° C. until dissolved to obtain phase A;

[0022] Heat glycerol, Tween 80, Span 80, Carbomer 940, EDTA-2Na and water at 70-80°C until dissolved to obtain phase B;

[0023] Mix ethylparaben and cinnamon oil to obtain phase C;

[0024] (2) Add phase B to phase A, then add phase C, stir and disperse, homogenize and emulsify at a speed of 400-600 r / min for 4-7 minutes, and continue stirring to obtain a moisturizing composition.

[0025] As a preferred embodiment of the preparation method of the present invention, it includes at least one of the following (I) to (II):

[0026] (I) In step (1), the heating condition of phase A and phase B is 75°C;

[0027] (II) In step (2), the rotation speed is 500 r / min and the emulsification time is 5 min.

[0028] In a third aspect, the present invention provides use of the above-mentioned moisturizing composition in the preparation of cosmetics.

[0029] Compared with the prior art, the present invention has the following beneficial effects:

[0030] The present invention selects vitamin E and cinnamon oil and combines them with a moisturizer, an emulsifier, a skin softener, a thickener, an antioxidant synergist, a preservative and water to form a moisturizing composition, which can promote the penetration of vitamin E and has the effects of long-term moisturizing, maintaining skin elasticity and repairing the epidermis. At the same time, the moisturizing composition of the present invention also has excellent antioxidant effect, and can be used to prepare a hand cream, which brings long-term moisturizing and antioxidant effects to the hand cream, and the cinnamon oil itself has antibacterial, anti-inflammatory and antipruritic effects, which can improve the skin itching problem caused by dryness and other problems, and achieve a long-term soothing effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 This is the cumulative penetration amount-time curve of vitamin E in different moisturizing compositions in Effect Example 2 of the present invention;

[0032] Figure 2 This is the cumulative penetration amount-time curve of cinnamaldehyde in different moisturizing compositions in Effect Example 2 of the present invention. DETAILED DESCRIPTION

[0033] In order to better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0034] Unless otherwise specified, other materials, reagents, etc. used in the embodiments, comparative examples and effect examples can be obtained from commercial sources.

[0035] Examples 1-5 and Comparative Examples 1-4

[0036] Examples 1-5 and Comparative Examples 1-4 respectively provide a moisturizing composition and a preparation method thereof. The components and amounts of the moisturizing composition are shown in Table 1. The preparation method comprises the following steps:

[0037] (1) heating the components of phase A in Table 1 at 75° C. until dissolved to obtain phase A;

[0038] Heat the components of phase B in Table 1 at 75°C until dissolved to obtain phase B;

[0039] Mix ethylparaben and cinnamon oil to obtain phase C:

[0040] (2) Add phase B to phase A, then add phase C, stir and disperse, homogenize and emulsify at a speed of 500 r / min for 5 minutes, continue stirring, and cool to room temperature to obtain a moisturizing composition

[0041] Table 1 Components and amounts of different moisturizing compositions (parts by weight)

[0042]

[0043]

[0044] Effect Example 1

[0045] The moisturizing compositions obtained in Examples 1-3 and Comparative Examples 1-2 were subjected to a 1,1-diphenyl-2-trinitrophenylhydrazine (DPPH) free radical scavenging experiment to detect their antioxidant efficacy. The specific scheme is as follows:

[0046] Preparation of DPPH working solution: Accurately weigh 0.00394 g of DPPH into a 100 mL volumetric flask, add anhydrous ethanol to dilute to the scale, shake well, and obtain 0.1 mM DPPH ethanol solution.

[0047] Preparation of test solution: 2 g of the moisturizing composition of Examples 1-3 and Comparative Examples 1 and 2 were dissolved in 10 mL of anhydrous ethanol to prepare test solutions.

[0048] Accurately measure 2 mL of each test solution and 2 mL of DPPH working solution, mix them evenly, protect from light for 30 minutes, and measure the absorbance value A1 at a wavelength of 516 nm. 2 mL of anhydrous ethanol mixed with 2 mL of DPPH solution is measured as A0, and the clearance rate is calculated according to the following formula. The results are shown in Table 2:

[0049]

[0050] Table 2 DPPH scavenging rate of different moisturizing compositions

[0051] Group DPPH clearance rate (%) Comparative Example 1 16.90％ Comparative Example 2 22.85％ Example 1 27.35％ Example 2 31.56％ Example 3 36.33％

[0052] As shown in Table 2, the DPPH scavenging rates of the moisturizing compositions of Examples 1-3 are much higher than those of Comparative Examples 1-2, and the DPPH scavenging rate of Example 3 is the highest, which indicates that the moisturizing composition of the present invention has excellent antioxidant capacity. As the amount of cinnamon oil increases, its antioxidant capacity also increases, and the addition of cinnamon oil can synergistically improve the antioxidant capacity of squalane and vitamin E in the moisturizing composition.

[0053] Effect Example 2

[0054] The moisturizing compositions obtained in Examples 1-3 and Comparative Examples 2-4 were subjected to an in vitro percutaneous permeation test to detect the relationship between vitamin E and cinnamon oil. The specific scheme is as follows:

[0055] Prepare vitamin E standard solutions with concentrations of and respectively, measure their absorbance at 291nm, and draw a standard curve with vitamin E concentration as the horizontal axis and absorbance corresponding to different concentrations as the vertical axis. The corresponding vitamin E concentration of the sample to be tested is calculated according to the standard curve. The construction method of the standard curve of cinnamaldehyde is similar to that of vitamin E, except that the wavelength of absorbance measurement is 284nm.

[0056] SD rats (220-250g), male, 8 in total, were adapted and fed for 24 hours. After the rats were anesthetized with isoflurane, the long hair on the abdomen was shaved, and then the remaining short hair was removed with a depilatory cream. After feeding for 24 hours, they were killed, and the skin of the hairless part of the rats was immediately cut off, the reverse side was laid flat, the subcutaneous tissue and fat were separated, and 0.9% saline was repeatedly rinsed until clean, and the undamaged skin was immersed in 0.9% saline and stored at -20°C for later use.

[0057] Take the spare rat skin and thaw it, fix it at one end of the diffusion cell, make the skin surface face the supply chamber, fill the receiving chamber with 30% ethanol saline solution, make it in close contact with the dermis, (37±0.5)℃, 100r / min constant speed magnetic stirring, turn on the TP-6 ​​transdermal diffusion tester, make it pre-equilibrate for 30 minutes, then accurately weigh 2g of the moisturizing composition of Examples 1-3 and Control Examples 2-4 and place it in the supply chamber, make it in close contact with the skin and apply it evenly, and conduct 3 parallel experiments in each group. Sample 4mL at 0.5, 1, 2, 4, 6, 8, 10, 12, and 24h, and supplement with an equal volume of receiving solution. After filtering the sample with a 0.22μm microporous filter membrane, use ultraviolet spectrophotometry to determine the content of vitamin E and cinnamaldehyde, and calculate the cumulative penetration amount Q. The results are shown in Tables 3-4 and Figure 1-2 The cumulative penetration calculation formula is as follows:

[0058]

[0059] Where V 总 is the total volume of the receiving liquid in the receiving chamber; Cn is the sample concentration measured at the nth sampling point; Ci is the drug concentration in the receiving liquid from the first sampling to the last sampling, i = 1, 2, ..., n-1; V 取 is the volume of each sampling; A is the penetration area (cm 2 ).

[0060] Table 3 Cumulative penetration of vitamin E in different moisturizing compositions (mg / cm 2 )

[0061]

[0062]

[0063] Depend on Figure 1 As shown in Table 3, the cumulative penetration amounts of Examples 1-3 are higher than those of Comparative Examples 2-4, showing better permeability, which indicates that cinnamon oil can greatly promote the penetration of vitamin E, and the cumulative penetration amounts are very different from those of Comparative Examples 3 and 4 containing rose essential oil and sweet orange oil, indicating that compared with commonly used plant essential oils, the use of cinnamon oil can not only reconcile the odor of the moisturizing composition but also promote the penetration of the effective ingredient vitamin E, thereby better exerting the moisturizing, hydrating, and anti-oxidation effects; in addition, the cumulative penetration amount shows an upward trend within 24 hours, indicating that cinnamon oil can promote the transdermal absorption of vitamin E for a long time, thereby achieving a long-lasting moisturizing and anti-oxidation effect.

[0064] Table 4 Cumulative penetration of cinnamaldehyde in different moisturizing compositions (mg / cm 2 )

[0065] Sampling time / h Example 1 Example 2 Example 3 0.5 0.007 0.057 0.050 1 0.010 0.097 0.110 2 0.016 0.156 0.202 4 0.028 0.214 0.336 6 0.039 0.262 0.517 8 0.049 0.306 0.616 10 0.060 0.370 0.720 12 0.070 0.434 0.989 24 0.115 0.581 1.208

[0066] The main component of cinnamon oil is cinnamaldehyde, so the cumulative permeation amount of cinnamon oil was determined by measuring the cumulative permeation amount of cinnamaldehyde. Figure 2 It can be seen that the cumulative penetration of cinnamaldehyde in the three groups of examples is constantly increasing, which shows that cinnamaldehyde has good skin permeability and continuous penetration within 24 hours, indicating that cinnamaldehyde can exert its antibacterial and antipruritic effects for a long time and achieve a long-lasting soothing effect.

[0067] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the present invention.

Claims

1. A moisturizing composition, characterized in that: The moisturizing composition comprises the following components in parts by mass: 4.48-5.86 parts of moisturizer, 2.236-4.612 parts of emulsifier, 0.26-0.66 parts of skin softener, 0.052-0.292 parts of thickener, 0.052-0.292 parts of antioxidant synergist, 0.01-0.22 parts of preservative, 0.168-0.568 parts of vitamin E, 0.04-0.4 parts of cinnamon oil and 30.116-30.516 parts of solvent.

2. The moisturizing composition according to claim 1, characterized in that: The moisturizing composition comprises the following components in parts by mass: 5.26 parts of moisturizer, 3.412 parts of emulsifier, 0.46 parts of skin softener, 0.092 parts of thickener, 0.092 parts of antioxidant synergist, 0.02 parts of preservative, 0.368 parts of vitamin E, 0.4 parts of cinnamon oil and 30.316 parts of solvent.

3. The moisturizing composition according to claim 1 or 2, characterized in that: The moisturizing agent includes at least one of liquid paraffin, squalane and glycerol; the mass ratio of the liquid paraffin, squalane and glycerol is liquid paraffin:squalane:glycerol=(0.808-1.308):(1.084-1.384):(2.568-2.968).

4. The moisturizing composition according to claim 3, characterized in that: The mass ratio of liquid paraffin, squalane and glycerin in the moisturizing agent is liquid paraffin:squalane:glycerin=1.108:1.384:2.

768.

5. The moisturizing composition according to claim 1 or 2, characterized in that: The emulsifier comprises at least one of glyceryl monostearate, glyceryl caprylate, stearic acid, triethanolamine, Tween 80 and Span 80; the mass ratio of glyceryl monostearate, glyceryl caprylate, stearic acid, triethanolamine, Tween 80 and Span 80 is glyceryl monostearate: glyceryl caprylate: stearic acid: triethanolamine: Tween 80: Span 80 = (1.084-1.584): (0.54-0.94): (0.084-0.384): (0.084-0.384): (0.444-0.844): (0.052-0.292).

6. The moisturizing composition according to claim 5, characterized in that: The mass ratio of glyceryl monostearate, caprylic decanoate, stearic acid, triethanolamine, Tween 80 and Span 80 in the emulsifier is glyceryl monostearate: caprylic decanoate: stearic acid: triethanolamine: Tween 80: Span 80=1.384:0.74:0.184:0.184:0.644:0.

276.

7. The moisturizing composition according to claim 1 or 2, characterized in that: The preservative is ethyl paraben; the antioxidant synergist is EDTA-2Na; the skin softener is isopropyl palmitate; and the thickener is carbomer 940.

8. The method for preparing the moisturizing composition according to any one of claims 1 to 7, characterized in that: The following steps are involved: (1) heating liquid paraffin, glyceryl monostearate, caprylic decanoate, stearic acid, squalane, isopropyl palmitate, vitamin E and triethanolamine at 70-80° C. until dissolved to obtain phase A; Heat glycerol, Tween 80, Span 80, Carbomer 940, EDTA-2Na and water at 70-80°C until dissolved to obtain phase B; Mix ethylparaben and cinnamon oil to obtain phase C; (2) Add phase B to phase A, then add phase C, stir and disperse, homogenize and emulsify at a speed of 400-600 r / min for 4-7 minutes, and continue stirring to obtain a moisturizing composition.

9. The preparation method according to claim 8, characterized in that: Including at least one of the following (I) to (II): (I) In step (1), the heating condition of phase A and phase B is 75°C; (II) In step (2), the rotation speed is 500 r / min and the emulsification time is 5 min.

10. Use of the moisturizing composition according to any one of claims 1 to 7 in the preparation of cosmetics.

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