Chinese herbal medicine cough and asthma relieving patch and preparation process thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicine patches, mainly relates to a traditional Chinese medicine patch and a preparation method thereof, and in particular relates to a Chinese herbal medicine patch for relieving cough and asthma and a preparation process thereof. Eight raw materials including ephedra, semen brassicae, euphorbia kansui, pink reineckea herb, perillaseed, asarum, elaeagnus pungens and herba ardisiae japonicae are selected, and the cough and asthma relieving effect of the traditional Chinese medicine is improved through the synergistic effect of the ephedra extracting solution, the elaeagnus pungens and the herba ardisiae japonicae under the enzymolysis condition; the thorny elaeagnus fruit enzymatic hydrolysate and the Japanese ardisia herb enzymatic hydrolysate have a synergistic effect to inhibit staphylococcus epidermidis, and the ephedra herb enzymatic hydrolysate, the thorny elaeagnus fruit enzymatic hydrolysate and the Japanese ardisia herb enzymatic hydrolysate have a synergistic effect to relieve children tic disorder.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine patches, and mainly relates to a traditional Chinese medicine patch and a preparation method thereof, and in particular to a traditional Chinese herbal medicine cough and asthma relieving patch and a preparation process thereof. Background Art

[0002] The history of patches can be traced back to primitive society, when people knew how to use natural materials such as leaves and grass stems to apply to wounds to treat trauma. These early external application materials were later found to have the effect of relieving pain, stopping bleeding, and even accelerating wound healing. Over time, this external application therapy gradually evolved, and people began to use Chinese herbal medicines with specific medical effects to make patches. By the Tang Dynasty, the use of patches had become more common, and they were further developed and improved during the Song Dynasty. During the Ming Dynasty, patches became a widely used folk medicine. During the Qing Dynasty, some famous doctors began to make Chinese medicine into pastes and apply them to the affected area to treat diseases. By the beginning of the 20th century, patches had become a modern Chinese medicine external patch, which was widely used in the treatment and rehabilitation of various diseases.

[0003] The research direction of the inventor is to modify the Chinese medicine in the patch by enzymatic hydrolysis technology. After a large number of experiments, an enzymatic hydrolysis method with good effect was screened out. This patent is improved on the basis of the "Anasthma and Cough Relief Patch and Preparation Method" (authorization announcement number CN100386103C) that the applicant has already applied for and disclosed.

[0004] On this basis, the inventor and his team conducted further research to broaden the therapeutic effect of the patch and enhance the efficacy of the cough and asthma relief patch through microbial enzymatic modification. Summary of the invention

[0005] In view of this, the present invention selects ephedra extract, elaeagnus fruit and dwarf camellia sinensis to synergistically enhance the antitussive and antiasthmatic effects of traditional Chinese medicine under enzymatic hydrolysis conditions. At the same time, under enzymatic hydrolysis conditions, the elaeagnus fruit hydrolysate and the dwarf camellia sinensis hydrolysate synergistically have the effect of inhibiting Staphylococcus epidermidis. The synergistic effects of ephedra extract, elaeagnus fruit hydrolysate and dwarf camellia sinensis hydrolysate have the effect of alleviating tic disorders in children.

[0006] In a first aspect, the present invention provides a Chinese medicine combination enzymatic hydrolyzate, which is obtained by enzymatic hydrolysis of a Chinese medicine composition; the Chinese medicine composition comprises 18-22g of ephedra, 4-5g of elaeagnus fructus and 9-11g of camellia sinensis by weight; and the enzyme is cellulase.

[0007] In a second aspect, the present invention provides a Chinese medicine patch, which has the effects of relieving cough and asthma, inhibiting Staphylococcus epidermidis and alleviating tic disorders in children.

[0008] A preparation method of a Chinese herbal medicine patch for relieving cough and asthma, the specific preparation method is as follows:

[0009] S1, eight kinds of raw materials including ephedra, white mustard seeds, kansui, auspicious grass, perilla seeds, asarum, elaeagnus and dwarf tea were ground, sieved and dried respectively;

[0010] S2, weigh 18-22g of ephedra, add 4-6 times of water, extract with water at 95°C for 1.5h, and filter to obtain the ephedra extract;

[0011] S3, weighing 4-5g of Elaeagnus chinensis, 9-11g of Camellia sinensis and all the ephedra extract prepared in step S2 and mixing them to obtain a composition, subjecting the composition to ultrasonic treatment at 50°C for 30min, adjusting the pH value to 3, adding 100-120U of cellulase, placing the composition in a water bath at 50-55°C for enzymolysis for 2-3h, taking it out, and filtering it to obtain a Chinese medicine combination enzymolysis solution;

[0012] S4, weighing 18-22g of white mustard seeds, 9-11g of lucky grass, 14-16g of perilla seeds, 9-11g of asarum, 4-6g of kansui and the Chinese medicine combination hydrolyzate prepared in step S3, adding 760mL of 65-70% ethanol to extract for 6-8h, and then using heating distillation to reflux extraction for 6h; then adding 560mL of 50-60% ethanol to reflux extraction for 2h, combining the filtrate, and concentrating the filtrate to an extract with a relative density of 1.20 (60°C), to obtain a Chinese medicine extract;

[0013] S5. Preparation of cataplasm matrix: weigh 3.2-6.2g of polyvinyl alcohol, 1.9-2.5g of sodium carboxymethyl cellulose, and 3.9-7.3g of gelatin, add distilled water to make colloids respectively and put them into a blender, then add castor oil 1.6-2.8g, sodium polyacrylate 0.96-1.43g, Tween-80 1.15-1.72g, sorbic acid 0.07-0.105g, kaolin 3.5-4.8g, glycerol 6.3-10.2g, tartaric acid 7.45-12.35g, sorbitol 1.38-3.80g and gastric soluble film coating powder 15.6-22.6g in sequence, add the remaining distilled water and stir, so that the total amount of distilled water added twice is 38-52g, and after stirring, the cataplasm matrix can be obtained;

[0014] S6. Preparation of the cough and asthma relieving patch: add the Chinese medicine extract prepared in step S5 to the cataplasm matrix prepared in step S6, put it into a stirrer, and stir at a speed of 1000-1200 rpm for 15-20 min to obtain the cough and asthma relieving patch of the present invention.

[0015] Preferably, the cough and asthma relieving patch obtained in step S6 is subjected to processes such as coating, cutting, sorting, and sealing packaging to obtain a cough and asthma relieving patch product.

[0016] Preferably, the water used in the present invention is distilled water.

[0017] Preferably, the liquid-to-solid ratio of ephedra in step S2 of the present invention is 5:1.

[0018] Preferably, the drying in step S1 of the present invention is carried out at 105° C. for 2 hours.

[0019] Preferably, the sieve used in step S1 of the present invention is a 120-mesh sieve.

[0020] The present invention has the following beneficial effects:

[0021] 1. The elaeagnus fructus enzymolyte and the dwarf camellia sinensis enzymolyte in the present invention have the effect of inhibiting Staphylococcus epidermidis under the synergistic effect.

[0022] 2. Under the enzymatic hydrolysis conditions, the synergistic effect of ephedra extract, elaeagnus fruit and dwarf camellia sinensis can effectively enhance the cough and asthma relieving effects of traditional Chinese medicine.

[0023] 3. Under the enzymatic hydrolysis conditions of the present invention, the synergistic effect of the ephedra hydrolysate, the elaeagnus hydrolysate and the dwarf camellia enzymatic hydrolysate has the effect of alleviating tic disorders in children.

[0024] 4. The hydrophilic polymer material of the patch prepared by the present invention keeps the drug in an active state all the time, improves the skin penetration of the active ingredients of the drug, enables the drug to reach the lesion quickly and has a significant effect in the controlled and sustained release of the drug.

[0025] 5. The Chinese medicine patch prepared by the present invention can continuously release the drug ingredients and maintain the therapeutic effect for a long time.

[0026] 6. The present invention adopts a patch form for treatment, which solves the problem that patients who are not suitable for oral administration, such as infants, the elderly or patients with swallowing difficulties, need to take oral liquid medicine. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative labor.

[0028] Figure 1 This is a comparison chart of the number of coughs of mice in each group in Example 2.

[0029] Figure 2 3 is a comparison chart of the motor behavior and stereotyped behavior scores of rats in each group. DETAILED DESCRIPTION

[0030] The following describes the embodiments of the present invention by specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments, and the details in this specification can also be modified or changed in various ways based on different viewpoints and applications without departing from the spirit of the present invention. It should be noted that the following embodiments and features in the embodiments can be combined with each other without conflict.

[0031] In the present invention, white mustard seeds, ephedra, and dwarf camellia were purchased from Shunquanlong (Anguo) Pharmaceutical Co., Ltd.; auspicious grass was purchased from Suqian Dafuyuan Landscaping Co., Ltd.; kansui, perilla seeds, and asarum were purchased from Youcaotang Chinese Medicinal Materials Co., Ltd.; elaeagnus fruit was purchased from Shuyang County Yifang Flower Garden; and cellulase was purchased from Ningxia Xiasheng Industrial Group Co., Ltd.

[0032] Example 1

[0033] This example proves that the synergistic effect of the enzymatic hydrolysate of Elaeagnus fructus and the enzymatic hydrolysate of Camellia oleifera has the effect of inhibiting Staphylococcus epidermidis.

[0034] This embodiment provides a Chinese medicine combination enzymatic hydrolyzate, and the specific steps are as follows:

[0035] S1, eight kinds of raw materials including ephedra, white mustard seeds, kansui, auspicious grass, perilla seeds, asarum, elaeagnus and dwarf tea were ground, sieved and dried respectively;

[0036] S2. Weigh 18 g of ephedra, add 5 times of water, extract at 95°C for 1.5 h, and filter to obtain the ephedra extract;

[0037] S3. Weigh 4 g of Elaeagnus fructus, 9 g of Camellia oleifera and all the ephedra extract prepared in step S2, mix them to obtain a composition, and after ultrasonic treatment at 50° C. for 30 min, adjust the pH to 3, add 100 U of cellulase, place the mixture in a water bath at 50° C. for enzymatic hydrolysis for 2 h, take out, and filter to obtain a Chinese medicine combination enzymatic hydrolyzate.

[0038] Comparative Example 1: Except that Elaeagnus chinensis was not added in step S3, the remaining steps were the same as those in Example 1.

[0039] Comparative Example 2: Except that the dwarf tea was not added in step S3, the remaining steps were the same as those in Example 1.

[0040] Staphylococcus epidermidis assay: Staphylococcus epidermidis CICC-10294 (purchased from China Industrial Microbiological Culture Collection Center) was inoculated into brain heart infusion agar medium, cultured on a slant for 24 h, and diluted with PBS (phosphate buffer) (pH 7.3, 0.03 mol / L) to about 5.0 x 10 5 CFU / mL-4.5x10 6CFU / mL bacterial suspension is reserved. Take a sterile test tube, add 5.0mL of the Chinese medicine combination hydrolysate first, and after 5 minutes in a water bath at 20°C, add 0.1mL of the above test bacterial suspension, mix quickly and time for 10 minutes. After the test bacteria and the Chinese medicine combination hydrolysate interact with each other, take 1.0mL of the mixture of the test bacteria and the Chinese medicine combination hydrolysate and inoculate them into 2 plates respectively, and pour the culture medium. At the same time, use PBS instead of the Chinese medicine combination hydrolysate to carry out parallel experiments as a blank control group. The number of colonies recovered in the blank control group is 1.0x10 4 CFU / mL-9.0x10 4 CFU / mL. PBS and culture medium from the same batch were used as controls. All test samples and control samples were cultured at 37°C. The bacterial propagules were cultured for 48 hours, and the number of colonies was recorded. The test was repeated 3 times. The results are shown in Table 1:

[0041]

[0042] Table 1

[0043]

[0044] The experimental results show that the colony count of Staphylococcus epidermidis in the comparative example 1 group is 4.6x10 4 CFU / mL, the antibacterial rate was 6.12%, and the colony count of Staphylococcus epidermidis in the comparative example 2 group was 4.5x10 4 CFU / mL, and the antibacterial rate was 8.16%, and the antibacterial rate was less than 10%. It can be seen that the antibacterial effect of comparative example 1-2 is not good, and the colony count of Staphylococcus epidermidis in the embodiment 1 group is 2.2x10 4 CFU / mL, the antibacterial rate was 55.10%, the antibacterial rate was greater than 50%, and the antibacterial effect was obvious, indicating that Example 1 group had the effect of inhibiting Staphylococcus epidermidis, while Comparative Example 1 group and Comparative Example 2 group had no obvious effect, proving that the synergistic effect of Elaeagnus fructus enzymatic hydrolysate and Camellia oleifera enzymatic hydrolysate had anti-Staphylococcus epidermidis effect.

[0045] Example 2

[0046] This example demonstrates that under enzymatic hydrolysis conditions, the synergistic effect of ephedra extract, elaeagnus fruit and camellia sinensis has the ability to effectively enhance the cough and asthma relieving effects of traditional Chinese medicine.

[0047] This embodiment provides a method for preparing a Chinese herbal medicine patch for relieving cough and asthma, and the specific steps are as follows:

[0048] S1, eight kinds of raw materials including ephedra, white mustard seeds, kansui, auspicious grass, perilla seeds, asarum, elaeagnus and dwarf tea were ground, sieved and dried respectively;

[0049] S2, weigh 19g of ephedra, add 5 times water, extract with water at 95℃ for 1.5h, and filter to obtain the ephedra extract;

[0050] S3. Weigh 4.5 g of Elaeagnus fructus, 10 g of Camellia ternata and all the ephedra extract prepared in step S2, mix them to obtain a composition, and after ultrasonic treatment at 50° C. for 30 min, adjust the pH to 3, add 150 U of cellulase, place the mixture in a water bath at 53° C. for enzymatic hydrolysis for 2.5 h, take out, filter, and obtain a Chinese medicine combination enzymatic hydrolyzate.

[0051] S4, weighing 18g of white mustard seeds, 9g of auspicious grass, 14g of perilla seeds, 9g of asarum, 4g of kansui and the Chinese medicine combination hydrolyzate prepared in step S3, putting them into a multifunctional extraction tank, adding 760mL of 65% ethanol to extract for 6h, and then using heating distillation to reflux extraction for 6h; then adding 560mL of 50% ethanol to reflux extraction for 2h, combining the filtrate, and concentrating the filtrate to an extract with a relative density of 1.20 (60°C), to obtain a Chinese medicine extract;

[0052] S5. Preparation of the cataplasm matrix: weigh 5.2 g of polyvinyl alcohol, 2.1 g of sodium carboxymethyl cellulose, and 4.0 g of gelatin, add distilled water to make colloids respectively and put them into a blender, then add 2.0 g of castor oil, 0.96 g of sodium polyacrylate, 1.2 g of Tween-80, 0.07 g of sorbic acid, 3.5 g of kaolin, 10.17 g of glycerol, 8.0 g of tartaric acid, 2.0 g of sorbitol and 17.0 g of gastric-soluble film coating powder in sequence, add appropriate amount of distilled water and stir, so that the total amount of distilled water added twice is 43.8 g, and after stirring, the cataplasm matrix can be obtained;

[0053] S6. Preparation of cough and asthma relieving patch: add the Chinese medicine combination enzymatic hydrolyzate prepared in step S4 to the cataplasm matrix prepared in step S5, put it into a stirrer, and stir at 1000 rpm for 15 minutes to obtain the cough and asthma relieving patch.

[0054] Comparative Example 3: Except that Elaeagnus chinensis is not added in step S3, the remaining steps are the same as those in Example 2.

[0055] Comparative Example 4: Except that the dwarf tea is not added in step S3, the remaining steps are the same as those in Example 2.

[0056] Comparative Example 5: Except that no ephedra extract is added in step S3, the remaining steps are the same as those in Example 2.

[0057] Comparative Example 6: Except that no cellulase was added in step S3, and the combination of ephedra extract, elaeagnus fructus and camellia sinensis was directly used, the remaining steps were the same as those in Example 2.

[0058] Detection method: 70 SPF female KM mice (provided by Jinan Pengyue Experimental Animal Breeding Co., Ltd.), 20±2g, were randomly divided into 7 groups, 10 mice in each group, and all mice were depilated at the neck, with a depilatory area of ​​about 1.5cm 2 ; There were 1 blank group, 5 drug-dosing groups (Example 2 and Comparative Example 3-6 groups, the corresponding cough and asthma patches were applied to the hair removal area on the neck of the mice, and the dosage was 1.6g / kg) and a positive control group (pentoxyverine citrate tablets, oral dose 13.0mg / kg). The blank group was not given any drug, and the drug-dosing group was given once a day for a total of 7 days; 1 hour after the last dose, a cough-inducing and asthma-inducing instrument was used to atomize concentrated ammonia water for 13s, and the number of coughs of the mice within 2 minutes was recorded. The experimental results are as follows Figure 1 shown.

[0059] Figure 1 This is a comparison chart of the number of coughs of mice in each group in Example 2. It can be seen intuitively that the blank group mice had the highest number of coughs, followed by the comparative example 3-6 groups, which had a slightly lower number of coughs, and then the positive control group mice, which was even lower. Finally, the number of coughs of mice in Example 2 group was the lowest, indicating that the cough-relieving effects were from high to low, respectively, Example 2, positive control group, comparative example 3-6 groups, and blank group, confirming that Example 2 had the best cough-relieving and asthma-relieving effect.

[0060] Example 3

[0061] This example proves that under the enzymatic hydrolysis conditions, the synergistic effect of Ephedra sinica hydrolysate, Elaeagnus fructus hydrolysate and Camellia oleifera hydrolysate has the effect of alleviating tic disorders in children.

[0062] This embodiment provides a method for preparing a Chinese herbal medicine patch for relieving cough and asthma, and the specific steps are as follows:

[0063] S1, eight kinds of raw materials including ephedra, white mustard seeds, kansui, auspicious grass, perilla seeds, asarum, elaeagnus and dwarf tea were ground, sieved and dried respectively;

[0064] S2, weigh 20g of ephedra, add 5 times water, extract with water at 95℃ for 1.5h, and filter to obtain the ephedra extract;

[0065] S3, weighing 5 g of Elaeagnus chinensis, 11 g of Camellia sinensis and all the ephedra extract prepared in step S2, mixing to obtain a composition, performing ultrasound at 50°C for 30 min, adjusting the pH to 3, adding 120 U of cellulase, placing the mixture in a water bath at 55°C for enzymatic hydrolysis for 3 h, taking it out, and filtering it to obtain a Chinese medicine combination enzymatic hydrolyzate;

[0066] S4, weighing 22g of white mustard seeds, 11g of auspicious grass, 16g of perilla seeds, 11g of asarum, 6g of kansui and the Chinese medicine combination hydrolyzate prepared in step S3, putting them into a multifunctional extraction tank, adding 760mL of 70% ethanol to extract for 8h, and then using heating distillation to reflux extract for 6h; then adding 560mL of 60% ethanol to reflux extract for 2h, combining the filtrate, and concentrating the filtrate to an extract with a relative density of 1.20 (60°C), to obtain a Chinese medicine extract;

[0067] S5. Preparation of the cataplasm matrix: weigh 6.0 g of polyvinyl alcohol, 2.4 g of sodium carboxymethyl cellulose, and 7.0 g of gelatin, add distilled water to make colloids respectively and put them into a blender, then add 2.5 g of castor oil, 1.4 g of sodium polyacrylate, 1.6 g of Tween-80, 0.103 g of sorbic acid, 4.5 g of kaolin, 10.0 g of glycerol, 9.0 g of tartaric acid, 1.897 g of sorbitol and 15.6 g of gastric-soluble film coating powder in sequence, add appropriate amount of distilled water and stir, so that the total amount of distilled water added twice is 38 g, and after stirring, the cataplasm matrix can be obtained;

[0068] S6. Preparation of cough and asthma relieving patch: add the Chinese medicine extract prepared in step S5 to the cataplasm matrix prepared in step S6, put into a stirrer, and stir at 1200 rpm for 20 minutes to obtain the cough and asthma relieving patch.

[0069] Comparative Example 7: Except that no ephedra extract is added in step S3, the remaining steps are the same as those in Example 3.

[0070] Comparative Example 8: Except that Elaeagnus chinensis is not added in step S3, the remaining steps are the same as those in Example 3.

[0071] Comparative Example 9: Except that dwarf tea is not added in step S3, the remaining steps are the same as those in Example 3.

[0072] 70 SPF male SD rats (provided by Jinan Pengyue Experimental Animal Breeding Co., Ltd.) were selected, 210±

[0073] The rats were randomly assigned to 14 cages, 5 in each cage, and were acclimated for one week in a constant temperature and oxygen supply environment at 25±2℃ before the experiment officially began. The entire experimental process strictly followed the national experimental animal management regulations.

[0074] Grouping: 70 rats were randomly divided into 7 groups, namely blank group, model group, positive control group, Example 3 group, and comparative example 7-9 groups, with 10 rats in each group. The abdomen of all rats was depilated, and the depilated area was about 3.0 cm 2 .

[0075] Modeling: Except for the blank group, rats in other groups were intraperitoneally injected with 300 mg / kg of iminodipropionitrile, once / 1d, for 7 consecutive days, to induce tics in rats. Motor behavior scores and stereotyped behavior scores were performed according to the methods in Table 2 and Table 3 below (when the motor behavior and stereotyped behavior scores were both ≥2 points, the modeling was successful). After successful modeling, the positive control group was given 27 mg / kg of 2g / L sulpiride suspension. The corresponding cough and asthma patches were applied to the depilated areas of the rat abdomen in Example 3 and Comparative Examples 7-9, with a dosage of 0.8 g / kg. The blank group and the model group were gavaged with the same volume of normal saline as the positive control group, once a day, for 28 consecutive days. The motor behaviors of rats in each group were observed and scored according to Tables 2 and 3. The results are as follows Figure 2 shown.

[0076] Table 2

[0077]

[0078] Table 3

[0079]

[0080]

[0081] Figure 2 It is a comparison chart of motor behavior and stereotyped behavior scores of rats in each group. As can be seen from the results, compared with the blank group (motor behavior score and stereotyped behavior score are both 0 points), the motor behavior score and stereotyped behavior score of the model group rats are significantly increased. Compared with the model group, there is no significant change in the motor behavior score and stereotyped behavior score of the comparative example 7-9 group rats, the motor behavior score and stereotyped behavior score of the embodiment 3 group rats are significantly reduced, and the tic symptoms are significantly alleviated, confirming that the synergistic effect of the three ephedra hydrolysate, elaeagnus hydrolysate and dwarf tea hydrolysate under enzymatic conditions has the effect of alleviating tic disorders in children.

[0082] The above-mentioned embodiments only express the specific implementation methods of the present invention, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the protection scope of the present invention. It should be pointed out that, for those skilled in the art, without departing from the concept of the present invention, any other changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principle of the present invention should be equivalent replacement methods and are included in the protection scope of the present invention.

Claims

1. A Chinese medicine combination enzymatic hydrolysate, characterized in that: The Chinese medicine combination enzymatic hydrolysate is obtained by enzymatic hydrolysis of the Chinese medicine composition; the Chinese medicine composition comprises 18-22g of ephedra, 4-5g of elaeagnus fructus and 9-11g of camellia sinensis by weight; the enzyme used in the enzymatic hydrolysis is cellulase.

2. The Chinese medicine combination enzymatic hydrolysate according to claim 1, characterized in that: The ephedra in the Chinese medicine combination enzymatic hydrolysate is an ephedra extract prepared by water extraction technology.

3. Antitussive and antiasthmatic patch, characterized in that: The cough and asthma relieving patch is mainly obtained by mixing a traditional Chinese medicine extract and a cataplasm matrix; the traditional Chinese medicine extract is composed of 5 kinds of natural plant Chinese medicinal materials and the traditional Chinese medicine combination enzymatic hydrolysate described in claim 2.

4. The cough and asthma relieving patch according to claim 3, characterized in that: The five natural plant Chinese medicinal materials include 18-22g of white mustard seeds, 9-11g of lucky grass, 14-16g of perilla seeds, 9-11g of asarum, and 4-6g of kansui in parts by weight.

5. The cough and asthma relieving patch according to claim 3, characterized in that: The cataplasm matrix includes, by mass fraction, 3.9-7.3% gelatin, 3.2-6.2% polyvinyl alcohol, 1.9-2.5% sodium carboxymethyl cellulose, 1.6-2.8% castor oil, 0.96-1.43% sodium polyacrylate, 1.15-1.72% Tween-80, 0.07-0.105% sorbic acid, 3.5-4.8% kaolin, 6.3-10.2% glycerol, 7.45-12.35% tartaric acid, 1.38-3.80% sorbitol, 15.6-22.6% gastric soluble film coating powder and 38-52% distilled water.

6. The antitussive and antiasthmatic patch according to any one of claims 3 to 5, which has the efficacy of relieving cough and asthma, and alleviating tic disorders in children.

7. The preparation method of the cough and asthma relieving patch according to claim 6, wherein the specific preparation method is as follows: Eight raw materials, S1, ephedra, mustard seeds, kansui, jixiangcao, perilla seeds, asarum, elaeagnus and dwarf tea, were ground and sieved respectively; S2, weigh 18-22g of ephedra, add 4-6 times of water, extract with water at 95°C for 1.5h, and filter to obtain the ephedra extract; S3, weighing 4-5g of Elaeagnus chinensis, 9-11g of Camellia sinensis and all the ephedra extract prepared in step S2 and mixing them to obtain a composition, subjecting the composition to ultrasonic treatment at 50°C for 30min, adjusting the pH value to 3, adding 100-120U of cellulase, placing the composition in a water bath at 50-55°C for enzymolysis for 2-3h, taking it out, and filtering it to obtain a Chinese medicine combination enzymolysis solution; S4, weigh 18-22g of white mustard seeds, 9-11g of lucky grass, 14-16g of perilla seeds, 9-11g of asarum, 4-6g of kansui and the Chinese medicine combination hydrolyzate prepared in step S3, add 760mL of 65-70% ethanol to extract for 6-8h, then use heating distillation method, reflux extraction for 6h to filter and take the filtrate; add 560mL of 50-60% ethanol to the filter residue and reflux extraction for 2h, combine the filtrate, and concentrate the filtrate to an extract with a relative density of 1.20 (60°C) to obtain a Chinese medicine extract; S5. Preparation of cataplasm matrix: weigh 3.2-6.2g of polyvinyl alcohol, 1.9-2.5g of sodium carboxymethyl cellulose, and 3.9-7.3g of gelatin, add distilled water to make colloids respectively and put them into a blender, then add castor oil 1.6-2.8g, sodium polyacrylate 0.96-1.43g, Tween-80 1.15-1.72g, sorbic acid 0.07-0.105g, kaolin 3.5-4.8g, glycerol 6.3-10.2g, tartaric acid 7.45-12.35g, sorbitol 1.38-3.80g and gastric soluble film coating powder 15.6-22.6g in sequence, add the remaining distilled water and stir, so that the total amount of distilled water added twice is 38-52g, and after stirring, the cataplasm matrix can be obtained; S6. Preparation of cough and asthma relieving patch: add the Chinese medicine extract prepared in step S4 to the cataplasm matrix prepared in step S5, put into a stirrer, and stir at a speed of 1000-1200 rpm for 15-20 min to obtain the cough and asthma relieving patch.

8. The method for preparing the cough and asthma relieving patch according to claim 7, characterized in that: In step S2, the liquid-to-solid ratio of ephedra is 5:

1.

9. The method for preparing the cough and asthma relieving patch according to claim 7, characterized in that: The sieve in step S1 is a 120-mesh sieve.

Images