Traditional Chinese medicine composition with effects of relieving restlessness and soothing nerves, traditional Chinese medicine preparation and preparation method and application thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition with restlessness relieving and nerve calming effects, a traditional Chinese medicine preparation and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from radix bupleuri, processed rhizoma pinelliae, radix scutellariae, fructus aurantii, caulis bambusae in taeniam, pericarpium citri reticulatae, poria cocos, rhizoma coptidis, semen ziziphi spinosae, caulis polygoni multiflori, cortex albiziae, nacre mother of pearl and honey-fried licorice root. The traditional Chinese medicine preparation provided by the invention has the effects of relieving restlessness and soothing nerves, can improve the sleep quality of insomnia and accompanying anxiety symptoms, is excellent in compatibility and considerable in curative effect, and can obviously treat and improve the sleep quality of anxiety insomnia and accompanying anxiety symptoms through years of clinical curative effect observation.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and specifically relates to a traditional Chinese medicine composition with the effects of relieving restlessness and calming the nerves, a traditional Chinese medicine preparation, and a preparation method and application thereof. Background Art

[0002] The prevalence of insomnia is increasing year by year, and it is attracting more and more attention. Short-term sleep will affect the mental state and work efficiency of the next day, and long-term insomnia can cause dysfunction of the nervous-immune-endocrine system, resulting in symptoms such as headaches, body pain, and night sweats. At the same time, it increases the incidence of many chronic diseases such as stroke, hypertension, and diabetes. About 1 / 3 of a person's life is spent in sleep. Sleep occupies an important position in normal life activities, so it deserves our attention.

[0003] Traditional Western medicine treatment is mainly based on sedatives and hypnotics. If it is anxiety disorder-related insomnia or affective disorder-related insomnia, it is often supplemented with anti-anxiety and antidepressant drugs. However, these drugs will have various adverse reactions, such as drowsiness, ataxia, drug addiction, withdrawal reaction, weight gain, constipation, etc. In severe cases, insomnia and anxiety will be aggravated, and patients' acceptance and compliance are poor. Cognitive behavioral therapy (CBT-I) is the preferred treatment for adult insomnia recommended by domestic and foreign guidelines, but CBT-I has high requirements for practitioners, is time-consuming, slow to take effect, and has low patient cooperation. It is difficult to implement in clinical practice and has not yet been popularized in China.

[0004] The pathogenesis is nothing more than dysfunction of the internal organs, disharmony of yin and yang, qi and blood, which leads to the loss of nourishment or disturbance of the mind. The clinical principle is to tonify the deficiency and purge the excess, adjust yin and yang, and calm the mind and spirit as the basic treatment method. For excess syndrome, it is advisable to clear the heart and purge fire, clear fire and resolve phlegm, clear the liver and purge heat; for deficiency syndrome, it is advisable to tonify the heart and spleen, invigorate qi and calm the nerves. Studies have shown that 2 / 3 of insomnia patients are accompanied by mental and emotional problems. However, the existing syndrome differentiation and treatment of insomnia does not take improving emotions as the core point to solve sleep problems, or lacks experience in improving complex emotions, and only stays on "chatting" and soothing the liver and regulating qi. Professor Zhang Yonghua used the emotional syndrome differentiation system in the process of clinical diagnosis and treatment of insomnia, and found that most patients complained that they had difficulty falling asleep because of emotional problems such as irritability, worry, overthinking, and easy tension. Among them, irritability and anger are the most common, which manifests as irritability and insomnia or frequent dreams and easy awakening, rapid speech, headache, head swelling, bitter mouth and dry mouth, hot flashes and sweating, dry stool, etc.

[0005] Therefore, as people pay more attention to insomnia and anxiety, developing an efficient and safe Chinese medicine preparation that can relieve restlessness and calm the nerves will be of great significance and value. Summary of the invention

[0006] The purpose of the present invention is to overcome the above-mentioned problems existing in the traditional technology and to provide a Chinese medicine composition, a Chinese medicine preparation and a preparation method and application thereof having the effects of relieving restlessness and calming the nerves.

[0007] In order to achieve the above technical objectives and the above technical effects, the present invention is implemented through the following technical solutions:

[0008] The invention provides a Chinese medicine composition with the effects of relieving restlessness and calming the nerves. The Chinese medicine composition is prepared from bupleurum, processed pinellia, scutellaria, fructus aurantii, bamboo shavings, tangerine peel, tuckahoe, coptis root, spiny jujube seed, smilax china, bark of julibrissin, mother-of-pearl and roasted liquorice.

[0009] Relative to 10 parts by weight of the bupleurum, the content of the processed pinellia is 10-14 parts by weight, the content of the scutellaria is 14-16 parts by weight, the content of the fructus aurantii is 10-14 parts by weight, the content of the bamboo shavings is 8-12 parts by weight, the content of the tangerine peel is 8-12 parts by weight, the content of the poria is 14-16 parts by weight, the content of the coptis chinensis is 4-8 parts by weight, the content of the spiny jujube seed is 14-16 parts by weight, the content of the polysaccharide is 14-16 parts by weight, the content of the julibrissin bark is 28-32 parts by weight, the content of the mother-of-pearl is 28-32 parts by weight, and the content of the roasted liquorice is 4-6 parts by weight.

[0010] Preferably, relative to 10 parts by weight of the bupleurum, the content of the processed pinellia is 12 parts by weight, the content of the scutellaria is 15 parts by weight, the content of the fructus aurantii is 12 parts by weight, the content of the bamboo shavings is 10 parts by weight, the content of the tangerine peel is 10 parts by weight, the content of the poria is 15 parts by weight, the content of the coptis chinensis is 6 parts by weight, the content of the spiny jujube seed is 15 parts by weight, the content of the polyphylla is 15 parts by weight, the content of the julibrissin bark is 30 parts by weight, the content of the mother-of-pearl is 30 parts by weight, and the content of the roasted liquorice is 5 parts by weight.

[0011] The present invention also provides a method for preparing a Chinese medicine preparation with the effects of relieving restlessness and calming the nerves. The Chinese medicine preparation is a Chinese medicine decoction prepared from bupleurum, processed pinellia, scutellaria, fructus aurantii, bamboo shavings, dried orange peel, tuckahoe, coptis root, spiny jujube seed, smilax china, bark of julibrissin, mother of pearl and roasted liquorice. The method comprises the following steps:

[0012] 1) After weighing accurately, add mother of pearl and cook for 20-40 minutes, then add bupleurum, processed pinellia, scutellaria, fructus aurantii, bamboo shavings, dried orange peel, tuckahoe, coptis root, spiny jujube seed, smilax china, bark of julibrissin, and roasted liquorice. Bring to a boil over high heat, then switch to low heat and maintain for 10-30 minutes, then pour out the decoction;

[0013] 2) Add clean water, boil all the medicines over high heat, then simmer for 10 to 30 minutes, and pour out the decoction;

[0014] 3) Mix the two decoctions to obtain a Chinese medicine decoction;

[0015] Relative to 10 parts by weight of the bupleurum, the content of the processed pinellia is 10-14 parts by weight, the content of the scutellaria is 14-16 parts by weight, the content of the fructus aurantii is 10-14 parts by weight, the content of the bamboo shavings is 8-12 parts by weight, the content of the tangerine peel is 8-12 parts by weight, the content of the poria is 14-16 parts by weight, the content of the coptis chinensis is 4-8 parts by weight, the content of the spiny jujube seed is 14-16 parts by weight, the content of the polysaccharide is 14-16 parts by weight, the content of the julibrissin bark is 28-32 parts by weight, the content of the mother-of-pearl is 28-32 parts by weight, and the content of the roasted liquorice is 4-6 parts by weight.

[0016] The present invention also provides a method for preparing a Chinese medicine preparation with the effects of relieving restlessness and calming the nerves. The Chinese medicine preparation is a granule prepared from bupleurum, processed pinellia, scutellaria, fructus aurantii, bamboo shavings, dried orange peel, tuckahoe, coptis root, spiny jujube seed, smilax china, bark of julibrissin, mother of pearl and roasted liquorice. The method comprises the following steps:

[0017] 1) Accurately weigh Bupleurum, processed Pinellia, Scutellaria, Citrus aurantium, Rhizoma Anemarrhenae, Tangerine peel, Poria, Rhizoma Coptidis, Semen Ziziphi Spinosae, Caulis Sophorae Fructus, Cortex Albizziae, Mother of Pearl, and Radix Glycyrrhizae, chop or crush appropriately, and place in a suitable decoction container;

[0018] 2) Add appropriate amount of water to submerge the medicinal materials, soak for appropriate time, heat and boil, separate the decoction after a certain period of time, repeat the decoction 2-3 times, and collect the decoction;

[0019] 3) After the decoction is centrifuged or filtered by sedimentation, it is concentrated at low temperature to a specified concentration, and the extract concentrated to a certain specific gravity is kneaded with auxiliary materials, and an appropriate amount of wetting agent is added if necessary, and the granules are granulated and dried to obtain the Chinese medicine granules;

[0020] Relative to 10 parts by weight of the bupleurum, the content of the processed pinellia is 10-14 parts by weight, the content of the scutellaria is 14-16 parts by weight, the content of the fructus aurantii is 10-14 parts by weight, the content of the bamboo shavings is 8-12 parts by weight, the content of the tangerine peel is 8-12 parts by weight, the content of the poria is 14-16 parts by weight, the content of the coptis chinensis is 4-8 parts by weight, the content of the spiny jujube seed is 14-16 parts by weight, the content of the polysaccharide is 14-16 parts by weight, the content of the julibrissin bark is 28-32 parts by weight, the content of the mother-of-pearl is 28-32 parts by weight, and the content of the roasted liquorice is 4-6 parts by weight.

[0021] The present invention also provides a method for preparing a Chinese medicine preparation with the effects of relieving restlessness and calming the nerves, characterized in that the Chinese medicine preparation is a pill made from bupleurum, processed pinellia, scutellaria, fructus aurantii, bamboo shavings, tangerine peel, tuckahoe, coptis root, spiny jujube seed, smilax china, bark of julibrissin, mother of pearl and roasted liquorice, and the method comprises the following steps:

[0022] 1) Accurately weigh Bupleurum, processed Pinellia, Scutellaria, Citrus aurantium, Rhizoma Anemarrhenae, Tangerine peel, Poria, Rhizoma Coptidis, Semen Ziziphi Spinosae, Caulis Sophorae Fructus, Cortex Albizziae, Mother of Pearl, and Radix Glycyrrhizae Radix and grind them into fine powder;

[0023] 2) sieving, mixing, refining honey, mixing the medicine, rolling into pills, and drying to obtain Chinese medicine pills;

[0024] Relative to 10 parts by weight of the bupleurum, the content of the processed pinellia is 10-14 parts by weight, the content of the scutellaria is 14-16 parts by weight, the content of the fructus aurantii is 10-14 parts by weight, the content of the bamboo shavings is 8-12 parts by weight, the content of the tangerine peel is 8-12 parts by weight, the content of the poria is 14-16 parts by weight, the content of the coptis chinensis is 4-8 parts by weight, the content of the spiny jujube seed is 14-16 parts by weight, the content of the polysaccharide is 14-16 parts by weight, the content of the julibrissin bark is 28-32 parts by weight, the content of the mother-of-pearl is 28-32 parts by weight, and the content of the roasted liquorice is 4-6 parts by weight.

[0025] The present invention also provides a method for preparing a Chinese medicine preparation with the effects of relieving restlessness and calming the nerves. The Chinese medicine preparation is a capsule prepared from bupleurum, processed pinellia, scutellaria, fructus aurantii, bamboo shavings, dried orange peel, tuckahoe, coptis root, spiny jujube seed, smilax china, bark of julibrissin, mother of pearl and roasted liquorice. The method comprises the following steps:

[0026] 1) Accurately weigh Bupleurum, processed Pinellia, Scutellaria, Citrus aurantium, Rhizoma Anemarrhenae, Tangerine peel, Poria, Rhizoma Coptidis, Semen Ziziphi Spinosae, Caulis Sophorae Fructus, Cortex Albizziae, Mother of Pearl, and Radix Glycyrrhizae, chop or crush appropriately, and place in a suitable decoction container;

[0027] 2) Add appropriate amount of water to submerge the medicinal materials, soak for appropriate time, heat and boil, separate the decoction after a certain period of time, repeat the decoction 2-3 times, and collect the decoction;

[0028] 3) After centrifugation or sedimentation filtration of the decoction, the decoction is concentrated to a specified concentration at low temperature, and a pharmaceutically acceptable excipient is added or not added to obtain a Chinese medicine capsule;

[0029] Relative to 10 parts by weight of the bupleurum, the content of the processed pinellia is 10-14 parts by weight, the content of the scutellaria is 14-16 parts by weight, the content of the fructus aurantii is 10-14 parts by weight, the content of the bamboo shavings is 8-12 parts by weight, the content of the tangerine peel is 8-12 parts by weight, the content of the poria is 14-16 parts by weight, the content of the coptis chinensis is 4-8 parts by weight, the content of the spiny jujube seed is 14-16 parts by weight, the content of the polysaccharide is 14-16 parts by weight, the content of the julibrissin bark is 28-32 parts by weight, the content of the mother-of-pearl is 28-32 parts by weight, and the content of the roasted liquorice is 4-6 parts by weight.

[0030] The present invention also provides a traditional Chinese medicine preparation prepared by the preparation method.

[0031] The present invention also provides the use of the above-mentioned Chinese medicine composition or the Chinese medicine preparation prepared by the above-mentioned preparation method in preparing a medicine with the effect of relieving restlessness and calming the nerves.

[0032] The efficacy of the components in the formula of the present invention is described as follows:

[0033] Bupleurum: It is the dried root of the Umbelliferae plant Bupleurum or Angustifolia. It tastes pungent and bitter, is slightly cold in nature, and enters the liver, gallbladder, heart, and triple burner meridians. It has the effects of calming and reducing fever, relieving liver depression, and raising Yang Qi. Bupleurum is used together with Citrus aurantium, which is good at promoting Qi and eliminating accumulation, to harmonize the liver and spleen, regulate Qi, and make the Qi rise and fall in an orderly manner. "Leigong Paoyao Yaoxing Jie" says that it "treats typhoid fever, heart heat, phlegm in the stomach and intestines, Qi accumulation, cold and heat evil qi, pain under the ribs, dredges the liver and wood, and remove the old and bring in the new."

[0034] Processed Pinellia: It is the dried tuber of the plant Pinellia of the Araceae family. It is pungent in taste and warm in nature. It enters the spleen, stomach and lung meridians. It has the functions of drying dampness and resolving phlegm, lowering adverse reactions and stopping vomiting, and eliminating lumps and dispersing knots. Pinellia is dry in nature and can resolve phlegm. The phlegm it resolves is mainly caused by the spleen failing to resolve dampness and gathering to form phlegm. It is an important medicine for treating damp phlegm, so it can be used for internal phlegm stagnation and chest and abdominal distension. It can be used together with dried tangerine peel and Poria cocos. "Ben Cao Jing Jie" states: "It is used to treat cold and heat in cold and heat, hardness in the heart, chest distension, cough, dizziness, sore throat, intestinal rumbling, lowering qi and stopping sweating." Because raw Pinellia is poisonous, the modern "Chinese Pharmacopoeia" clearly stipulates that "it is generally used after processing for oral administration", that is, it must be processed with auxiliary materials before it can be taken orally. Due to different processing methods, it can be divided into ginger Pinellia, French Pinellia, Qing Pinellia and Zhuli Pinellia, among which ginger Pinellia has a stronger effect of lowering adverse reactions and is more commonly used in clinical practice.

[0035] Scutellaria baicalensis: The dried root of the Lamiaceae plant Scutellaria baicalensis. This herb is bitter and cold in nature, and enters the lung, gallbladder, spleen, large intestine, and small intestine meridians. Scutellaria baicalensis enters the liver and gallbladder meridians, and can clear the stagnant heat of the Shaoyang meridian, relieve depression and relieve restlessness; Scutellaria baicalensis also enters the heart meridian, and can clear the heart fire and calm the mind; Scutellaria baicalensis enters the lung and large intestine meridians, and can clear the fire in the upper jiao and drain the heat in the large intestine to clear the upper and drain the lower, clear the bowels and drain the heat, and calm the mind and stabilize the spirit. Pharmacological studies have shown that Scutellaria baicalensis has significant sedative and hypnotic effects.

[0036] Citrus aurantium: It is the dried immature fruit of the plant Citrus aurantium and its cultivated varieties of the Rutaceae family. It tastes bitter, pungent, and sour, and is slightly cold in nature. It enters the spleen and stomach meridians. It has the effects of regulating qi and relieving chest tightness, relieving stagnation and eliminating accumulation. Citrus aurantium is bitter and descends downward, is good at relieving chest tightness and diaphragm tightness, and promotes qi and eliminates stagnation. It is an important medicine for treating chest tightness caused by qi stagnation. Citrus aurantium is used in combination with Pinellia tuber and dried orange peel to promote qi and eliminate accumulation, resolve phlegm and eliminate stagnation. "Leigong Paoyao Yaoxing Jie" says: "It is used to reduce the highest qi in the chest, eliminate the phlegm in the heart, and relieve the stagnant qi in the abdomen."

[0037] Bamboo Shavings: It is the dried middle layer of the stems of the grass family plants, such as green bamboo, big head bamboo or light bamboo. It tastes sweet, is slightly cold in nature, and enters the lung, stomach, heart and gallbladder meridians. It has the effects of clearing heat and resolving phlegm, relieving restlessness and stopping vomiting. The "Pharmaceuticals" says that it is "specially used to clear phlegm and heat, and is a good product for calming the mind and relieving depression." Bamboo Shavings can relieve liver and gallbladder to prevent stagnation and heat. Combined with Coptis chinensis, which is bitter and cold and can relieve heart fire, it can treat the heart and gallbladder at the same time, clearing heat and resolving phlegm, calming the mind and relieving depression. Bamboo Shavings has the nature of clearing and descending, and is combined with the warm tangerine peel, one warming and one clearing, to enhance the effect of strengthening the spleen and drying dampness.

[0038] Tangerine peel: It is the dried mature peel of the citrus plant and its cultivated varieties of the Rutaceae family. It tastes bitter and pungent, is warm in nature, and enters the lung and spleen meridians. Its main effects are regulating qi and strengthening the spleen, and drying dampness and resolving phlegm. Tangerine peel has a pungent aroma and fragrance. Pungent is good for the lungs, and fragrant is good for the spleen. It can promote qi and relieve stomachache, strengthen the spleen and harmonize the stomach, and disperse lung qi. It complements Pinellia tuber to enhance the power of regulating qi and resolving phlegm, reflecting the idea of ​​"regulating qi first to treat phlegm, and phlegm will disappear when qi is smooth", which is the basic structure of Erchen Decoction. "Ancient and Modern Medical Mirror: Phlegm and Fluid" states: "Erchen Decoction is a key medicine for treating phlegm, and it can cure all phlegm in the body."

[0039] Poria: It is the sclerotium of the fungus Poria of the family Polyporaceae. It is sweet, light and flat in nature, and enters the heart, lung, spleen and kidney meridians. It has the effects of diuresis, invigorating the spleen, and calming the mind. "Compendium of Materia Medica" says: "Later generations must use Poria to treat palpitations. Therefore, Zhang Jiegu said that wind dizziness and heart deficiency can only be cured by Poria, but Poria can also treat heart disease." Its pharmacological effects also reflect a sedative effect.

[0040] Coptis chinensis: It is the dried rhizome of Coptis chinensis, Coptis triangularis, or Coptis chinensis of the Ranunculaceae family. It is bitter and cold in nature, and enters the heart, spleen, stomach, liver, gallbladder, and large intestine meridians. This product clears away heat and dampness, and can also clear the heart fire to relieve restlessness. "Zhenzhu Nang" records: "Its uses are six: purging heart fire, one; removing damp heat in the middle jiao, the second." "Ben Cao Zhengyi" says that it "relieves all excess damp fire." Studies have found that Coptis chinensis alkaloids can reduce patients' anxiety and depression, and also have a certain sedative and hypnotic effect.

[0041] Ziziphus jujuba seed: It is the mature seed of Ziziphus jujuba, a deciduous shrub or small tree of the Rhamnaceae family. This product tastes sweet and sour, has a neutral nature, and enters the heart and liver meridians. It has the functions of nourishing the heart and liver, calming the mind and tranquilizing the nerves, and astringing sweat. "Compendium of Materia Medica" says: "Its kernel is sweet and moist, so it is used to treat gallbladder deficiency and insomnia, thirst and sweating; it is used raw to treat gallbladder heat and sleep, and both are medicines for the foot Jueyin and Shaoyang." It is intended to explain that this medicine is sweet and slow to nourish, replenish the deficiency and calm the five internal organs, harmonize yin and yang, and achieve the functions of calming the mind, eliminating restlessness, calming the nerves and calming palpitations. "Bielu" also says: "It can relieve restlessness and insomnia,... sweating, thirst, nourish the middle, benefit the liver qi, strengthen the tendons and bones, and help the yin qi." Pharmacological research shows that Ziziphus jujuba seed decoction has sedative and hypnotic effects, and can counteract the excitatory effects caused by caffeine.

[0042] Polygonum multiflorum: It is the dried vine stem of Polygonum multiflorum, a plant of the Polygonaceae family. This product tastes sweet and slightly bitter, enters the heart and liver meridians, and has the effect of nourishing the heart and calming the mind. The "Compendium of Materia Medica" says that Polygonum multiflorum: "At night, the vines intersect, which is a sign of the union of yin and yang." Pinellia and Polygonum multiflorum are also "yin and yang coordination", which leads yang into yin to help sleep, and when yin and yang are coordinated, the mind is at peace and sleep is achieved. It is often used for insomnia caused by the disharmony of yin and yang, "yang not entering yin", "yin not restraining yang", and phlegm-heat. It can be used to treat all insomnia symptoms.

[0043] Albizzia bark: It is the dried bark of the Albizzia julibrissin plant of the Leguminosae family. This product is sweet and neutral in nature. It enters the heart, liver, and lung meridians. It is good at soothing the liver and relieving depression, soothing the mind and calming the nerves. It is suitable for treating restlessness and irritability caused by emotional frustration, anger, and depression. "Ben Jing" says: "It calms the five internal organs, harmonizes the mind, and makes people happy and worry-free." It calms the mind and relieves depression by calming the five internal organs and making the mind happy. Pharmacological studies have shown that it has a hypnotic effect.

[0044] Mother of pearl: It is the shell of the clams of the family Hyriopsis cumingii, the crown of pleats, or the family Pearl Oyster. It is salty and cold in nature, and enters the liver and heart meridians. It has the effects of calming the liver and suppressing yang, calming the mind and calming the nerves, and improving eyesight and removing cataracts. Mother of pearl also enters the heart meridian and can calm the mind and calm the nerves, so it is often used for restlessness, palpitations, insomnia, irritability, etc. "New Reference to Medicinal Pieces" records: "It calms the liver and suppresses yang, calms the mind and soul, and calms epilepsy.

[0045] Roasted Licorice: It is a processed product of the leguminous plant licorice. It tastes sweet and has a neutral nature. It can enter the heart meridian and spleen meridian, and has the effects of invigorating qi and restoring pulse, tonifying spleen and stomach, and harmonizing medicinal properties. "Collection of Experiences of Hundreds of Compatible Drugs" records: The characteristics of the compatibility of Yuanhu, Walengzi, and Licorice are: invigorating qi, resolving phlegm and blood stasis, stopping acid and relieving pain, and licorice replenishes the middle and replenishes qi. Relieves urgency and relieves pain. The combination of the three medicines can transform phlegm and blood stasis, complement each other, and resolve stagnation while relieving urgency, so it will not hurt the body and increase the effect of stopping acid and relieving pain. This product is sweet and neutral, has a mild medicinal property, can rise and fall, can float and sink, so it can be used with various cold and hot, warm and cool tonic and purgative drugs, and has the effect of relieving medicinal properties and harmonizing hundreds of drugs.

[0046] The beneficial effects of the present invention are:

[0047] The innovative compatibility of the present invention lies in that the Bupleurum in the prescription is good at soothing the liver and relieving depression, and lifting the clear qi in the body; the processed Pinellia is pungent and warm, dries dampness and resolves phlegm, eliminates lumps and resolves knots; the Scutellaria is bitter and cold, and is good at removing dampness and heat in the middle and upper jiao; the Citrus aurantium is bitter and descends downward, is good at relieving chest tightness and diaphragm, and promotes qi and eliminates lumps, which is an important medicine for treating chest tightness caused by qi stagnation. The above four flavors are all monarch drugs, and they are used together to rise and fall, harmonize the liver and spleen, make the qi rise and fall orderly, treat the spleen and lungs together, and use cold and heat together, which not only treats the source of phlegm, but also treats the organ storing phlegm, and are also the main drugs for relieving emotions and regulating irritability. Bamboo shavings clear heat and resolve phlegm, calm the mind and relieve depression; Tangerine peel has a pungent aroma and flavor, promotes qi and relieves fullness, strengthens the spleen and stomach; Poria strengthens the spleen and promotes diuresis, calms the mind and soothes the mind; Coptis chinensis clears heart fire to relieve restlessness; Ziziphus jujuba seeds harmonize yin and yang, calms the mind and relieves restlessness; the above five flavors are ministerial drugs, and are used with the main drug to help clear heat and resolve phlegm, promote qi and relieve depression; Tangerine peel and Pinellia tuber are used together, taking the meaning of "two Chens", which enhances their ability to regulate qi and resolve phlegm; Coptis chinensis is used with Scutellaria baicalensis to clear heat and dry dampness, and enhance the effect of purging fire and relieving restlessness; Bamboo shavings, Poria cocos, and Ziziphus jujuba seeds enhance the effect of relieving depression, relieving restlessness and calming the mind. Polygonum multiflorum is sweet in taste, nourishes the heart and calms the mind; Albizzia julibrissin peel relieves depression and calms the mind; Mother of pearl is heavy in texture and enters the heart, which can calm the mind and soothe the mind. The three assist the ministerial drugs to help nourish the heart and relieve restlessness, and are the main drugs for calming the mind. Roasted Licorice root is sweet, moisturizing and harmonizing, and is a harmonizing agent. The combination of various medicines can treat both the symptoms and the root cause, and can treat both deficiency and excess, and can achieve the effects of clearing away heat and resolving phlegm, calming the mind and tranquilizing the nerves, so it is called "a prescription for eliminating restlessness and tranquilizing the nerves.

[0048] Through many years of clinical efficacy observation, the Chinese medicine preparation of the present invention can obviously treat and improve the sleep quality of anxiety-related insomnia and the accompanying anxiety symptoms. DETAILED DESCRIPTION

[0049] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0050] The relevant specific embodiments of the present invention are as follows:

[0051] Example 1

[0052] The mass ratio of a traditional Chinese medicine preparation with the effect of relieving restlessness and calming the nerves is: 10g of bupleurum, 12g of processed pinellia, 15g of scutellaria, 12g of fructus aurantii, 10g of bamboo shavings, 10g of dried tangerine peel, 15g of poria, 6g of coptis root, 15g of spiny jujube seed, 15g of polyphylla, 30g of julibrissin bark, 30g of mother-of-pearl, and 5g of roasted liquorice.

[0053] Preparation: Soak the formulated amount of mother-of-pearl in water for 30 minutes and boil it over high heat. Then soak the remaining 12 Chinese medicinal herbs in water for 30 minutes and then add them in and boil them together. After boiling, keep it over low heat for 20 minutes and pour out the decoction. Add clean water to the medicinal residue and soak the Chinese medicinal herbs, boil them again, keep it over low heat, pour out the decoction, mix the two decoctions, and the result is a Chinese medicinal decoction with the effect of relieving restlessness and calming the nerves.

[0054] Example 2

[0055] The mass ratio of a traditional Chinese medicine preparation with the effect of relieving restlessness and calming the nerves is: 10g of bupleurum, 12g of processed pinellia, 15g of scutellaria, 12g of fructus aurantii, 10g of bamboo shavings, 10g of dried tangerine peel, 15g of poria, 6g of coptis root, 15g of spiny jujube seed, 15g of polyphylla, 30g of julibrissin bark, 30g of mother-of-pearl, and 5g of roasted liquorice.

[0056] Preparation: Soak the formulated amount of mother-of-pearl in water for 30 minutes and then boil it over high heat. Soak the remaining 12 Chinese medicinal materials in water for 30 minutes and then add them in and boil them together. After boiling, keep the heat at low heat for 20 minutes and pour out the decoction. Add clean water to the residue and soak the Chinese medicinal materials and repeat the decoction for 2 to 3 times. Collect the decoctions, concentrate them to a specified concentration after centrifugal separation or sedimentation filtration, and knead the extract concentrated to a certain specific gravity with the auxiliary materials. Add an appropriate amount of wetting agent when necessary, granulate them, and dry them to obtain Chinese medicinal granules with the effect of relieving restlessness and calming the nerves.

[0057] Example 3

[0058] The mass ratio of a traditional Chinese medicine preparation with the effect of relieving restlessness and calming the nerves is: 10g of bupleurum, 12g of processed pinellia, 15g of scutellaria, 12g of fructus aurantii, 10g of bamboo shavings, 10g of dried tangerine peel, 15g of poria, 6g of coptis root, 15g of spiny jujube seed, 15g of polyphylla, 30g of julibrissin bark, 30g of mother-of-pearl, and 5g of roasted liquorice.

[0059] Preparation: Soak the formulated amount of mother-of-pearl in water for 30 minutes and boil it over high heat. Then soak the remaining 12 Chinese medicinal herbs in water for 30 minutes and then add them in and boil them together. After boiling, keep it over low heat for 20 minutes and pour out the decoction. Add clean water to the medicinal residue and soak the Chinese medicinal herbs, boil them again, keep it over low heat, pour out the decoction, mix the two decoctions, and the result is a Chinese medicinal decoction with the effect of relieving restlessness and calming the nerves.

[0060] Example 4

[0061] The mass ratio of a traditional Chinese medicine preparation with the effect of relieving restlessness and calming the nerves is: 10g of bupleurum, 12g of processed pinellia, 15g of scutellaria, 12g of fructus aurantii, 10g of bamboo shavings, 10g of dried tangerine peel, 15g of poria, 6g of coptis root, 15g of spiny jujube seed, 15g of polyphylla, 30g of julibrissin bark, 30g of mother-of-pearl, and 5g of roasted liquorice.

[0062] Preparation: Soak the formulated amount of mother-of-pearl in water for 30 minutes and boil it over high heat. Then soak the remaining 12 Chinese medicinal herbs in water for 30 minutes and then add them in and boil them together. After boiling, keep it over low heat for 20 minutes and pour out the decoction. Add clean water to the medicinal residue and soak the Chinese medicinal herbs, boil them again, keep it over low heat, pour out the decoction, mix the two decoctions, and the result is a Chinese medicinal decoction with the effect of relieving restlessness and calming the nerves.

[0063] Example 5

[0064] Clinical trials

[0065] Test methods and contents:

[0066] A total of 120 insomnia patients who met the diagnostic criteria of non-organic insomnia coded as F51.0 in ICD-10 and the syndrome differentiation criteria of phlegm-heat internal disturbance type in the "Clinical Guidelines for the Treatment of Insomnia with New Chinese Medicines" were selected and divided into an experimental group and a control group with 60 cases in each group using a random number table method.

[0067] The experimental group was given the Chinese herbal decoction obtained in Example 1 with the effect of relieving restlessness and calming the nerves, taken twice a day in the morning and evening; the control group was given 1 mg of sedative, taken half an hour before going to bed every night. The course of treatment was 4 weeks, and no other sedative hypnotic drugs were used in the course of treatment. The clinical efficacy was observed after 2 weeks and 4 weeks of treatment, and polysomnography (PSG) was performed on the two groups of patients before and after 4 weeks of treatment to observe the effect of the Chinese herbal decoction obtained in Example 1 with the effect of relieving restlessness and calming the nerves on PSG of insomnia patients.

[0068] Typical cases:

[0069] Case 1: Wang, female, 34 years old, complained of repeated insomnia for more than 2 years, 5-6 hours of sleep per night, easy to wake up early, difficult to fall asleep again after waking up, accompanied by upset, irritable mood, coughing up sputum from time to time, a little blood in the sputum, poor spirit during the day, decreased work efficiency, easy to worry about things, once visited an external hospital, treated with Chinese medicine decoction, poor effect. During the visit, the patient looked sleepy, had a good appetite, dry and thin stools, once a day, red tongue, thin white fur, and fine pulse. Diagnosis of anxiety-related insomnia. Given the Chinese medicine decoction treatment of Example 1, the sleep quality of the follow-up visit after 2 weeks was significantly improved, and the patient could fall asleep again after waking up early, and the sleep time could reach about 7 hours every night, but the irritability was still there; no follow-up visit after 4 weeks, and the patient was followed up later, and the sleep was basically normal, the energy was restored during the day, and the mood was stable, and the Chinese medicine had been stopped.

[0070] Case 2:

[0071] Li, female, 58 years old, complained of repeated insomnia for more than 5 years, difficulty falling asleep, need to stay in bed for 2-3 hours every night to fall asleep, shallow sleep and easy to wake up, dreamy, sometimes panic, irritable mood, once took sedative and hypnotic Western medicine treatment, the initial effect was significant, but still repeated insomnia, now stopped taking Western medicine. During the consultation, the patient was in good spirits, had normal appetite, two bowel movements, red tongue, thin yellow fur root, and thin and smooth pulse. Diagnosis: anxiety-related insomnia. Give the Chinese medicine decoction treatment of embodiment 1, and the sleep of the follow-up visit after 2 weeks is significantly better than before, and the bed can fall asleep for about half an hour, and the number of waking up in the middle of sleep is reduced, and irritability is not obvious, and the Chinese medicine decoction is continued to be given 14 doses to consolidate the effect.

[0072] The preferred embodiments of the present invention disclosed above are only used to help explain the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to specific implementation methods. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present invention, so that those skilled in the art can understand and use the present invention well. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. A Chinese medicine composition having the effect of relieving restlessness and calming the nerves, characterized in that: The traditional Chinese medicine composition is prepared from bupleurum root, processed pinellia tuber, scutellaria root, fructus aurantii, bamboo shavings, dried orange peel, tuckahoe, coptis root, spiny jujube seed, smilax china, bark of julibrissin, mother-of-pearl and roasted liquorice. Relative to 10 parts by weight of the bupleurum, the content of the processed pinellia is 10-14 parts by weight, the content of the scutellaria is 14-16 parts by weight, the content of the fructus aurantii is 10-14 parts by weight, the content of the bamboo shavings is 8-12 parts by weight, the content of the tangerine peel is 8-12 parts by weight, the content of the poria is 14-16 parts by weight, the content of the coptis chinensis is 4-8 parts by weight, the content of the spiny jujube seed is 14-16 parts by weight, the content of the polysaccharide is 14-16 parts by weight, the content of the julibrissin bark is 28-32 parts by weight, the content of the mother-of-pearl is 28-32 parts by weight, and the content of the roasted liquorice is 4-6 parts by weight.

2. The Chinese medicine composition according to claim 1, characterized in that: Relative to 10 parts by weight of the bupleurum, the content of the processed pinellia is 12 parts by weight, the content of the scutellaria is 15 parts by weight, the content of the fructus aurantii is 12 parts by weight, the content of the bamboo shavings is 10 parts by weight, the content of the tangerine peel is 10 parts by weight, the content of the poria is 15 parts by weight, the content of the coptis chinensis is 6 parts by weight, the content of the spiny jujube seed is 15 parts by weight, the content of the polyphylla is 15 parts by weight, the content of the julibrissin bark is 30 parts by weight, the content of the mother-of-pearl is 30 parts by weight, and the content of the roasted liquorice is 5 parts by weight.

3. A method for preparing a Chinese medicine preparation having the effect of relieving restlessness and calming the nerves, characterized in that: The Chinese medicine preparation is a Chinese medicine decoction made from bupleurum, processed pinellia, scutellaria, fructus aurantii, bamboo shavings, dried orange peel, tuckahoe, coptis root, spiny jujube seed, smilax china, bark of julibrissin, mother-of-pearl and roasted liquorice. The method comprises the following steps: 1) After weighing accurately, add mother of pearl and cook for 20-40 minutes, then add bupleurum, processed pinellia, scutellaria, fructus aurantii, bamboo shavings, dried orange peel, tuckahoe, coptis root, spiny jujube seed, smilax china, bark of julibrissin, and roasted liquorice. Bring to a boil over high heat, then switch to low heat and maintain for 10-30 minutes, then pour out the decoction; 2) Add clean water, boil all the medicines over high heat, then simmer for 10 to 30 minutes, and pour out the decoction; 3) Mix the two decoctions to obtain a Chinese medicine decoction; Relative to 10 parts by weight of the bupleurum, the content of the processed pinellia is 10-14 parts by weight, the content of the scutellaria is 14-16 parts by weight, the content of the fructus aurantii is 10-14 parts by weight, the content of the bamboo shavings is 8-12 parts by weight, the content of the tangerine peel is 8-12 parts by weight, the content of the poria is 14-16 parts by weight, the content of the coptis chinensis is 4-8 parts by weight, the content of the spiny jujube seed is 14-16 parts by weight, the content of the polysaccharide is 14-16 parts by weight, the content of the julibrissin bark is 28-32 parts by weight, the content of the mother-of-pearl is 28-32 parts by weight, and the content of the roasted liquorice is 4-6 parts by weight.

4. A method for preparing a Chinese medicine preparation having the effect of relieving restlessness and calming the nerves, characterized in that: The Chinese medicine preparation is a granule prepared from bupleurum, processed pinellia, scutellaria, fructus aurantii, bamboo shavings, dried orange peel, tuckahoe, coptis root, spiny jujube seed, smilax china, bark of julibrissin, mother-of-pearl and roasted liquorice. The method comprises the following steps: 1) Accurately weigh Bupleurum, processed Pinellia, Scutellaria, Citrus aurantium, Rhizoma Anemarrhenae, Tangerine peel, Poria, Rhizoma Coptidis, Semen Ziziphi Spinosae, Caulis Sophorae Fructus, Cortex Albizziae, Mother of Pearl, and Radix Glycyrrhizae, chop or crush appropriately, and place in a suitable decoction container; 2) Add an appropriate amount of water to submerge the medicinal materials, soak for an appropriate time, heat and boil, separate the decoction after a certain period of time, repeat the decoction 2 to 3 times, and collect the decoctions; 3) After the decoction is centrifuged or filtered by sedimentation, it is concentrated at low temperature to a specified concentration, and the extract concentrated to a certain specific gravity is kneaded with auxiliary materials, and an appropriate amount of wetting agent is added if necessary, and the granules are granulated and dried to obtain the Chinese medicine granules; Relative to 10 parts by weight of the bupleurum, the content of the processed pinellia is 10-14 parts by weight, the content of the scutellaria is 14-16 parts by weight, the content of the fructus aurantii is 10-14 parts by weight, the content of the bamboo shavings is 8-12 parts by weight, the content of the tangerine peel is 8-12 parts by weight, the content of the poria is 14-16 parts by weight, the content of the coptis chinensis is 4-8 parts by weight, the content of the spiny jujube seed is 14-16 parts by weight, the content of the polysaccharide is 14-16 parts by weight, the content of the julibrissin bark is 28-32 parts by weight, the content of the mother-of-pearl is 28-32 parts by weight, and the content of the roasted liquorice is 4-6 parts by weight.

5. A method for preparing a Chinese medicine preparation having the effect of relieving restlessness and calming the nerves, characterized in that: The Chinese medicine preparation is a pill made from bupleurum, processed pinellia, scutellaria, fructus aurantii, bamboo shavings, dried orange peel, tuckahoe, coptis root, spiny jujube seed, smilax china, bark of julibrissin, mother-of-pearl and roasted liquorice. The method comprises the following steps: 1) Accurately weigh Bupleurum, processed Pinellia, Scutellaria, Citrus aurantium, Rhizoma Anemarrhenae, Tangerine peel, Poria, Coptis chinensis, Semen Ziziphi Spinosae, Caulis Sophorae Fructus, Cortex Albizziae, Mother of Pearl, and Radix Glycyrrhizae Radix and grind them into fine powder; 2) sieving, mixing, refining honey, mixing the medicine, rolling into pills, and drying to obtain Chinese medicine pills; Relative to 10 parts by weight of the bupleurum, the content of the processed pinellia is 10-14 parts by weight, the content of the scutellaria is 14-16 parts by weight, the content of the fructus aurantii is 10-14 parts by weight, the content of the bamboo shavings is 8-12 parts by weight, the content of the tangerine peel is 8-12 parts by weight, the content of the poria is 14-16 parts by weight, the content of the coptis chinensis is 4-8 parts by weight, the content of the spiny jujube seed is 14-16 parts by weight, the content of the polysaccharide is 14-16 parts by weight, the content of the julibrissin bark is 28-32 parts by weight, the content of the mother-of-pearl is 28-32 parts by weight, and the content of the roasted liquorice is 4-6 parts by weight.

6. A method for preparing a Chinese medicine preparation having the effect of relieving restlessness and calming the nerves, characterized in that: The Chinese medicine preparation is a capsule prepared from bupleurum, processed pinellia, scutellaria, fructus aurantii, bamboo shavings, dried orange peel, tuckahoe, coptis root, spiny jujube seed, smilax china, bark of albizzia, mother of pearl and roasted liquorice. The method comprises the following steps: 1) Accurately weigh Bupleurum, processed Pinellia, Scutellaria, Citrus aurantium, Rhizoma Anemarrhenae, Tangerine peel, Poria, Rhizoma Coptidis, Semen Ziziphi Spinosae, Caulis Sophorae Fructus, Cortex Albizziae, Mother of Pearl, and Radix Glycyrrhizae, chop or crush appropriately, and place in a suitable decoction container; 2) Add an appropriate amount of water to submerge the medicinal materials, soak for an appropriate time, heat and boil, separate the decoction after a certain period of time, repeat the decoction 2 to 3 times, and collect the decoctions; 3) After centrifugation or sedimentation filtration of the decoction, the decoction is concentrated to a specified concentration at low temperature, and a pharmaceutically acceptable excipient is added or not added to obtain a Chinese medicine capsule; Relative to 10 parts by weight of the bupleurum, the content of the processed pinellia is 10-14 parts by weight, the content of the scutellaria is 14-16 parts by weight, the content of the fructus aurantii is 10-14 parts by weight, the content of the bamboo shavings is 8-12 parts by weight, the content of the tangerine peel is 8-12 parts by weight, the content of the poria is 14-16 parts by weight, the content of the coptis chinensis is 4-8 parts by weight, the content of the spiny jujube seed is 14-16 parts by weight, the content of the polysaccharide is 14-16 parts by weight, the content of the julibrissin bark is 28-32 parts by weight, the content of the mother-of-pearl is 28-32 parts by weight, and the content of the roasted liquorice is 4-6 parts by weight.

7. A Chinese medicine preparation obtained according to the preparation method according to any one of claims 3 to 6.

8. Use of the Chinese medicine composition according to claim 1 or 2, or the Chinese medicine preparation prepared by the preparation method according to any one of claims 3 to 6 in the preparation of a drug with the effect of relieving restlessness and calming the nerves.