A Chinese medicine composition for fighting lung cancer and its preparation method and application

Abstract

The present invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a Chinese medicine composition for anti-lung cancer, and a preparation method and application thereof. The Chinese medicine composition for anti-lung cancer of the present invention comprises 20-120 parts of Herba Agrimoniae, 5-15 parts of Radix Aconiti Lateralis Preparata, 5-20 parts of Dried Ginger, 10-30 parts of Radix Glycyrrhizae Preparata, 20-50 parts of Radix Astragali, 10-50 parts of Raw Gizzard Gizzard, 10-80 parts of Raw Malt, and 10-50 parts of Honeycomb. The present invention takes "decline of life gate fire" as the "starting point" of the basic pathogenesis of lung cancer, and refers to the pathological research of lung cancer, and proposes to treat lung cancer from warming and replenishing "fire of life gate", with "supporting yang, dispersing cold, relieving depression, and eliminating accumulation" as the main treatment method, and reuses "herba Agrimoniae Preparata" for anti-cancer and invigorating deficiency, treating both the symptoms and the root cause, and the mechanism is mutually referenced, and synergistic and synergistic; at the same time, with "experience in human use" as the "foothold", 3 cases and animal experiments are attached, and the feasibility, effectiveness and scientificity of this creation are proved by clinical practice and basic research.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and specifically relates to an anti-lung cancer traditional Chinese medicine composition and a preparation method and application thereof. Background Art

[0002] Lung cancer can be divided into small cell lung cancer and non-small cell lung cancer according to the pathological histological type. Non-small cell lung cancer includes adenocarcinoma, squamous cell carcinoma and other rare types. The histological characteristics of lung adenocarcinoma are glandular formation, containing more mucus, similar to the signs of "phlegm and dampness stagnation", with characteristics of cohesion, coldness, and dampness. Moreover, lung adenocarcinoma is different from other types of lung cancer. Its development speed is relatively slow, and its nature is mostly cold and yin, often showing symptoms such as coughing and coughing up white sputum. Therefore, lung adenocarcinoma is most closely related to yang deficiency and cold dampness.

[0003] "Lingshu·The Origin of All Diseases" says: "When accumulations first occur, they are caused by cold, and then they become accumulations." "Suwen·On Pain" points out: "Cold invades the membrane of the small intestine and the blood vessels, and the blood cannot flow into the meridians, and the blood and qi are retained and cannot flow, so they become accumulations." In their long-term clinical practice, ancient doctors have clearly recognized the key role of cold coagulation in the occurrence and development of malignant tumors. According to clinical observations, the vast majority of malignant tumors are hard in texture, which is consistent with the things produced by cold coagulation of yin. As stated in "Xizhuo of the Origin of Miscellaneous Diseases", "Accumulations, masses, and lumps are caused by the coagulation of phlegm and blood and food due to cold."

[0004] "Treatise on the Causes and Symptoms of Various Diseases: Consumption and Fatigue" says: "Accumulation is caused by coldness in the body. When blood and qi are weak, wind evil attacks the internal organs. Excessive coldness causes qi stagnation, and qi stagnation causes accumulation." The normal operation of the body's qi, blood, and body fluids depends on the warmth and promotion of yang qi. Life fire is the root of the body's yang qi. When the life gate fire is weak, the yang qi of the internal organs is weak, yin and cold are generated internally, condensing qi and blood, blocking the meridians, and eventually forming tangible pathological products such as phlegm and blood stasis, which will form accumulation over time. As pointed out in "Ding Ganren's Medical Cases: Swelling Cases": "Where yang qi does not reach, turbid yin condenses." Summary of the invention

[0005] The purpose of the present invention is to provide a traditional Chinese medicine composition for resisting lung cancer.

[0006] Another object of the present invention is to provide a method for preparing the above-mentioned Chinese medicine composition.

[0007] Another object of the present invention is to provide an application of the above-mentioned Chinese medicine composition.

[0008] According to a specific embodiment of the present invention, an anti-lung cancer Chinese medicine composition comprises, by weight, 20-120 parts of herb agrimony, 5-15 parts of cooked aconite, 5-20 parts of dried ginger, 10-30 parts of roasted licorice, 20-50 parts of raw astragalus, 10-50 parts of raw chicken gizzard lining, 10-80 parts of raw malt, and 10-50 parts of honeycomb.

[0009] The present invention takes the basic pathogenesis of lung cancer as "deficiency of life gate fire" as the "starting point", refers to the pathological research of lung cancer, proposes to treat lung cancer from the perspective of warming and nourishing the "life gate fire", takes "supporting yang, dispersing cold, relieving depression, and eliminating accumulation" as the main treatment methods, and makes heavy use of "herbaceous crane grass" for anti-cancer and deficiency-tonifying, treating both the symptoms and the root causes, with mutual reference of mechanisms and synergistic enhancement of effects; at the same time, taking "human experience" as the "landing point", the feasibility, effectiveness and scientificity of the present invention are proved by clinical practice and basic research.

[0010] According to a specific embodiment of the present invention, an anti-lung cancer Chinese medicine composition comprises, by weight, 30-60 parts of herb agrimony, 6-12 parts of cooked aconite, 9-18 parts of dried ginger, 12-24 parts of roasted licorice, 24-45 parts of raw astragalus, 18-45 parts of raw chicken gizzard lining, 18-45 parts of raw malt, and 12-36 parts of honeycomb.

[0011] According to a specific embodiment of the present invention, an anti-lung cancer Chinese medicine composition comprises, by weight, 45 parts of herba agrimonii, 6 parts of cooked aconite root, 15 parts of dried ginger, 20 parts of roasted licorice root, 30 parts of raw astragalus, 30 parts of raw chicken gizzard lining, 30 parts of raw malt, and 15 parts of honeycomb.

[0012] According to a specific embodiment of the present invention, a method for preparing a Chinese medicine composition for preventing lung cancer comprises the following steps:

[0013] (1) Add cooked aconite root to boiling water and simmer for 0.5-1 hour until the spicy sensation disappears;

[0014] (2) Add the pre-soaked agrimony, dried ginger, roasted licorice, raw astragalus, raw chicken gizzard lining and beehive, bring to a boil over high heat and then simmer over low heat, finally add raw malt and continue simmering for 10-15 minutes to obtain the Chinese medicine composition.

[0015] The present invention also provides the use of the above-mentioned traditional Chinese medicine composition in the preparation of anti-lung cancer drugs.

[0016] According to a specific embodiment of the present invention, an anti-lung cancer drug comprises the above-mentioned traditional Chinese medicine composition and pharmaceutically acceptable excipients.

[0017] According to a specific embodiment of the present invention, an anti-lung cancer drug is an oral preparation.

[0018] Preferably, the medicine is in the form of decoction, pill, powder, paste, wine, granule, tablet or capsule.

[0019] Traditional Chinese medicine believes that the gate of life contains vital energy, which is connected to the five internal organs, meridians, limbs, and bones through the vital energy. The "External Classics Micro-Words·The True Fire of the Gate of Life" points out: "The gate of life is the master of the twelve meridians... The fire of the twelve meridians is endless with the innate fire of the gate of life..." The gate of life governs the twelve meridians and twelve organs, and is the driving force of human life activities. The normal functioning of the physiological functions of the five internal organs depends on the promotion of the fire of the gate of life.

[0020] Based on long-term clinical experience and research on traditional theories, the inventors believe that the basic pathogenesis of lung cancer is the decline of the fire in the gate of life, which causes cold to accumulate and form endogenous tumors. The site of the disease may involve the five internal organs and is unified by the gate of life.

[0021] The treatment principles and treatment methods of the present invention are:

[0022] In clinical practice, the treatment of lung cancer should focus on the basic pathogenesis of "deficiency of life gate fire", and first warm and nourish "life gate fire", and should carry out "supporting yang, dispelling cold, relieving depression, and eliminating accumulation" throughout the treatment process. At the same time, the anti-cancer and tonic "Xianhecao" should be used to treat both the symptoms and the root causes, with the mechanisms of mutual reference and synergistic effect.

[0023] The prescription composition and explanation of the present invention:

[0024] (1) Ingredients: Herba Centipelagoe, cooked aconite root, dried ginger, roasted licorice root, raw astragalus root, raw chicken gizzard lining, raw malt, and beehive.

[0025] (2) Explanation of the prescription: "Herba aconitifolia" is used as the main drug to fight cancer and replenish deficiency. Aconite is a ball of fire, which replenishes the fire that is about to be extinguished. The pungent and warm dried ginger disperses it, and the sweetness of licorice suppresses the fire. Aconite, dried ginger and licorice are used together to hide the true fire and permanently consolidate the life. Raw Astragalus is added to replenish lung qi, raw malt soothes the liver and relieves depression, raw chicken gizzard eliminates symptoms and disperses nodules, and beehive attacks and breaks up accumulations, eliminating cancer tumors. All the drugs work together to support yang, dispel cold, relieve depression and eliminate accumulation.

[0026] (3) Pharmacological effects

[0027] Agrimony: It is good for the heart and liver meridians. It tastes bitter, astringent and flat. It has anti-cancer, tonifying, hemostasis, antimalarial, antidysentery and detoxification effects. The chemical components in Agrimony mainly include flavonoids, triterpenes, phenols, volatile oils, isocoumarins, organic acids, etc., which have pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibacterial, improving insulin resistance and inhibiting acetylcholinesterase. The total flavonoid extract of Agrimony has an inhibitory effect on human liver cancer cells HepG2. Active ingredients including palmitic acid, trans-squalene, α-linolenic acid and other ingredients can significantly inhibit the proliferation of tumor cells. In addition, Agrimony tannic acid has a significant inhibitory effect on human lung cancer cell lines (SPC-A-1), cervical cancer cell lines (Hela), human breast cancer cell lines (MCF-7) and poorly differentiated gastric mucinous adenocarcinoma (Mgc803) cultured in vitro.

[0028] Cooked Aconite: Also known as Aconite, Wufuzi, Heifuzi, Heishunpian. It enters the heart, kidney, and spleen meridians. It is pungent, sweet, and very hot; it can restore yang and rescue adverse conditions, replenish fire and assist yang, and dispel cold and dampness. The decoction and water extract of Heishunpian and its diester alkaloids (such as aconitine, mesaconitine, and mesaconitine), monoester alkaloids (such as benzoylmeaconitine, benzoylmeaconitine, and benzoylaconitine), and water-soluble alkaloids (such as neorin and sungolin) all have good anti-tumor activity, inhibiting the proliferation of human liver cancer cells (MHCC97) and reducing the invasion and cell migration ability of liver cancer cells. Aconite polysaccharides can also directly inhibit the growth of gastric cancer transplanted tumors and enhance the tumor inhibitory effect of chemotherapeutic drugs.

[0029] Dried ginger: enters the spleen, stomach, kidney, heart, and lung meridians. Pungent and hot. Warms the middle and dispels cold, restores yang and unclogs the meridians, dries dampness and eliminates phlegm, warms the lungs and transforms fluid. The main component of dried ginger, 6-shogaol, can not only inhibit the growth of tumor cells, but also promote the apoptosis of cancer cells. Dried ginger is often used in combination with other drugs to enhance the effect of warming yang and removing toxins, dispersing nodules and softening hard masses, so as to target the pathogenesis of tumor yang deficiency and cold stagnation.

[0030] Licorice root: sweet, neutral. It enters the heart, lung, spleen and stomach meridians. It has the effects of clearing away heat and detoxifying, removing phlegm and relieving cough, tonifying the spleen and lungs, and relieving pain. The chemical components of licorice root mainly include triterpenoid saponins, flavonoids, polysaccharides, coumarins and alkaloids. Licorice flavonoids play an anti-tumor role by inhibiting the proliferation of tumor cells and promoting autophagy, such as isoliquiritigenin.

[0031] Raw Astragalus: sweet in nature, slightly warm in taste, and enters the spleen and lung meridians. It has the effects of invigorating qi and strengthening the exterior, promoting diuresis and reducing swelling, promoting fluid and nourishing blood, relieving stagnation and relieving arthritis, expelling toxins and pus, and healing sores and promoting muscle regeneration. Astragalus can enhance the body's immunity and improve disease resistance. It maintains the stability of the immune system by "supporting the positive energy" and directly kills tumor cells by "dispelling evil spirits". Astragalus total flavonoids act on human hepatoma cells cultured in vitro, and are negatively correlated with apoptosis inhibitory proteins Survivin and Bcl-2, and positively correlated with apoptosis promoting protein Bax, thereby promoting apoptosis of liver cancer cells. In addition, astragalus polysaccharides play a role in the treatment of non-small cell lung cancer by promoting autophagy regulation of human lung cancer cells and affecting key autophagy pathways such as mTOR and Beclin-1. Astragalus polysaccharides show significant regulatory effects in human lung cancer cisplatin-resistant strain A549 / DDP cells, effectively reversing drug resistance and increasing cell sensitivity to cisplatin. Astragaloside IV can effectively alleviate the occurrence and development of lung cancer in mice, reduce the expression of Wnt-1, β-catenin, C-myc, and Cyclin D1 proteins, and inhibit the activation of the Wnt / β-catenin signaling pathway, thereby regulating the tumor microenvironment and preventing the occurrence of lung cancer.

[0032] Raw chicken gizzard lining: enters the spleen, stomach, small intestine, and bladder meridians. Sweet, flat. Strengthens the stomach and helps digestion, stops nocturnal emission and stops nocturnal emission. Chicken gizzard lining mainly contains proteins, amino acids, polysaccharides, trace elements, etc., which play the role of strengthening the stomach and digestion, stopping nocturnal emission and stopping nocturnal emission, and clearing the stranguria and removing stones. It is often used to treat indigestion, vomiting and diarrhea, malnutrition in children, enuresis, nocturnal emission, stones and pain in stranguria, gallbladder distension and flank pain, etc. Modern pharmacological studies have found that chicken gizzard lining has pharmacological effects such as regulating the functions of the digestive system and blood system, improving blood rheology, and inhibiting the growth of myomas. Chicken gizzard lining can activate factors related to the protection of gastric mucosa, improve the discomfort caused by gastric mucosal damage, and adjust gastrointestinal function. In the treatment of lung cancer, insect drugs are often used to promote blood circulation, reduce swelling and relieve pain, but these drugs are easy to hurt the stomach, so chicken gizzard lining is often added to protect the spleen and stomach.

[0033] Raw malt: enters the spleen and stomach meridians. Sweet, neutral. It promotes the flow of qi and helps digestion, invigorates the spleen and stimulates appetite, relieves lactation and relieves bloating. Malt contains more enzymes, including α- and β-amylases, proteolytic enzymes, hordenine, choline, cucurbitacin, betaine, α-codone, protein, amino acids, cytochrome C, etc. Malt and chicken gizzard lining play similar roles in invigorating the stomach and promoting digestion.

[0034] Beehive: It belongs to the stomach meridian. It is sweet and neutral. It can dispel wind, detoxify, kill insects and relieve pain. The chemical components of beehive mainly include flavonoids, terpenes, phenylpropanoids, steroids, etc. It has the effects of enhancing immunity, regulating endocrine function, analgesia, antibacterial, anti-inflammatory, anti-infection and antioxidant. Beehive has anti-cancer effects. There are records of beehive treating carbuncle and malignant ulcer in ancient literature. It is often used in modern clinical practice to treat breast cancer, lung cancer and nasopharyngeal cancer. It is an anti-cancer Chinese medicine with small toxic side effects and good efficacy. NVP-Ⅱ is extracted and purified from beehive, which has the effect of significantly inducing apoptosis of leukemia cells and inhibiting the proliferation of leukemia cells.

[0035] Beneficial effects of the present invention:

[0036] The Chinese medicine composition of the present invention is composed of 8 kinds of medicines, including herb of agrimony, cooked aconite root, dried ginger, roasted liquorice root, raw astragalus root, raw chicken gizzard lining, raw malt and honeycomb. Among them, herb of agrimony root is used to fight cancer and replenish deficiency, taking both the symptoms and the root into consideration. Aconite root is a ball of raging fire, which can replenish the fire that is about to be extinguished, and the pungent and warm dried ginger can disperse it, and the sweet liquorice can suppress the fire with earth; the three medicines are used together to hide the true fire and permanently consolidate the life. Raw astragalus root is added to replenish lung qi, raw malt can soothe the liver and relieve depression, raw chicken gizzard lining can eliminate symptoms and disperse knots, and honeycomb can attack and break accumulation, eliminate cancer tumors, and all the medicines are combined to play the functions of supporting yang, dispersing cold, relieving depression and eliminating accumulation.

[0037] The Chinese medicine composition of the invention is prepared from pure Chinese medicine and has less toxic and side effects. BRIEF DESCRIPTION OF THE DRAWINGS

[0038] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0039] Figure 1 Shows the product of the two diameters of the tumor in case 1 after treatment.

[0040] Figure 2 Shows the product of the two diameters of the tumor in case 2 after treatment.

[0041] Figure 3 Shows the product of the two diameters of the tumor in case 3 after treatment.

[0042] Figure 4 The animal experiment example shows the tumor size at different treatment times.

[0043] Figure 5 The body weights of mice at the end of treatment are shown in the Animal Experiment Example.

[0044] Figure 6 The tumor weight at the end of treatment in the animal experiment example is shown. DETAILED DESCRIPTION

[0045] To make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention will be described in detail below. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other implementation methods obtained by ordinary technicians in this field without creative work belong to the scope of protection of the present invention.

[0046] The invention discloses an anti-lung cancer Chinese medicine composition, which comprises, by weight, 20-120 parts of herba agrimonii, 5-15 parts of cooked aconite root, 5-20 parts of dried ginger, 10-30 parts of roasted licorice root, 20-50 parts of raw astragalus, 10-50 parts of raw chicken gizzard lining, 10-80 parts of raw malt and 10-50 parts of honeycomb.

[0047] The preparation method of the Chinese medicine composition of the present invention:

[0048] (1) Add cooked aconite root to boiling water and simmer for 0.5-1 hour until the spicy sensation disappears;

[0049] (2) Add the pre-soaked agrimony, dried ginger, roasted licorice, raw astragalus, raw chicken gizzard lining and beehive, bring to a boil over high heat and then simmer over low heat, finally add raw malt and continue simmering for 10-15 minutes to obtain the Chinese medicine composition.

[0050] Preferably, the weight proportion of herb is 30-60 parts, or any value within the above numerical range, for example, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59 or 60, or other values ​​within the above range, which are not listed here one by one.

[0051] Preferably, the weight proportion of cooked aconite root is 6-12 parts, or any value within the above numerical range, for example, 6, 7, 8, 9, 10, 11 or 12, or other values ​​within the above range, which are not listed here one by one.

[0052] Preferably, the weight proportion of dried ginger is 9-18 parts, or any value within the above numerical range, for example, 9, 10, 11, 12, 13, 14, 15, 16, 17 or 18, or other values ​​within the above range, which are not listed here one by one.

[0053] Preferably, the weight proportion of licorice root is 12-24 parts, or any value within the above numerical range, for example, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23 or 24, or other values ​​within the above range, which are not listed here one by one.

[0054] Preferably, the weight proportion of raw astragalus is 24-45 parts, or any value within the above numerical range, for example, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44 or 45, or other values ​​within the above range, which are not listed here one by one.

[0055] Preferably, the weight proportion of raw chicken gizzard lining is 18-45 parts, or any value within the above numerical range, for example, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44 or 45, or other values ​​within the above range, which are not repeated here one by one.

[0056] Preferably, the weight proportion of raw malt is 18-45 parts, or any value within the above numerical range, for example, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44 or 45, or other values ​​within the above range, which are not listed here one by one.

[0057] Preferably, the weight proportion of the honeycomb is 12-36 parts, or any value within the above numerical range, for example, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35 or 36, or other values ​​within the above range, which are not listed here one by one.

[0058] The dosage of the Chinese medicine composition of the present invention may vary with the mode of administration, dosage form and severity of the disease to be treated. The dosage regimen may be adjusted to provide the best therapeutic effect, and the specific dosage should also take into account factors such as the mode of administration and the physical condition of the subject of administration, which are all within the skill range of the art.

[0059] Example 1

[0060] The anti-lung cancer Chinese medicine composition of the present invention comprises, by weight (one weight part is equivalent to 1 g), 20 parts of herba agrimonii, 5 parts of cooked aconite root, 5 parts of dried ginger, 10 parts of roasted licorice root, 20 parts of raw astragalus, 100 parts of raw chicken gizzard lining, 10 parts of raw malt and 10 parts of honeycomb.

[0061] The preparation method of the Chinese medicine composition of the present invention:

[0062] First, take 300mL of boiling water and use low heat to boil the cooked aconite for 0.5-1 hour, until there is no spicy feeling in the mouth.

[0063] Then add the simultaneously soaked herb agrimony, dried ginger, roasted licorice, raw astragalus, raw chicken gizzard lining and beehive, add purified water to about 900 mL, bring to a boil over high heat and then simmer over low heat, when the medicinal liquid is about 350 mL, add raw malt, and continue decocting for 10-15 minutes until the medicinal liquid is about 300 mL, to obtain the traditional Chinese medicine composition.

[0064] Example 2

[0065] The anti-lung cancer Chinese medicine composition of the present invention comprises, by weight (one weight part is equivalent to 1 g), 45 parts of herba agrimonii, 6 parts of cooked aconite root, 15 parts of dried ginger, 20 parts of roasted licorice root, 30 parts of raw astragalus, 30 parts of raw chicken gizzard lining, 30 parts of raw malt and 15 parts of honeycomb.

[0066] Example 3

[0067] The anti-lung cancer Chinese medicine composition of the present invention comprises, by weight (one weight part is equivalent to 1 g), 120 parts of herba agrimonii, 15 parts of cooked aconite root, 20 parts of dried ginger, 30 parts of roasted licorice root, 50 parts of raw astragalus, 50 parts of raw chicken gizzard lining, 80 parts of raw malt and 50 parts of honeycomb.

[0068] Example 4 Typical Cases

[0069]

Case 1

[0070] Patient Gao, female, 66 years old. First visit in March 2023: On December 10, 2021, the patient was diagnosed with "lung lesions" for more than 8 months during a physical examination. She was treated in a tertiary hospital in Xiamen. Later, a lung puncture biopsy was performed. Pathology showed: lung malignancy (right lung adenocarcinoma). Combined with relevant examinations, it was evaluated as cT2N3M0, stage IIIB. Immunohistochemistry: CK7(+), Ki-67 (20% positive), TTF-1(+), EGFR-L858(-), EGFR-E746(-), ALK(-), p40(-). According to the results of genetic testing, the targeted drug "dacomitinib" was used for treatment. The tumor size was reduced from 5.9cm×2.9cm to 1.2cm×1.0cm, but then targeted drug resistance appeared, and the tumor size increased to 7.3cm×4.0cm. Later, she sought treatment with traditional Chinese medicine. Current symptoms: cough, sputum, fatigue, chest tightness, cold limbs, fear of cold, poor appetite, occasional irritability, irritability, poor sleep, 1-2 loose bowel movements per day, pale dark tongue, greasy white coating, deep and stringy pulse.

[0071] Combined with the patient's medical history, symptoms, signs, tongue and pulse, the TCM diagnosis was "lung accumulation" (Western medicine diagnosis was "lung cancer"), the basic pathogenesis was the decline of the gate of life fire, and the treatment was based on the "pathogenesis", with the main focus on "warming and nourishing the gate of life fire". This prescription was used for treatment, and the specific drugs are as follows:

[0072] 120g of Herba Agrimoniae, 12g of cooked aconite (fried first), 18g of dried ginger, 24g of roasted licorice, 45g of raw astragalus, 30g of raw chicken gizzard lining, 60g of raw malt, and 30g of beehive.

[0073] After 14 days of treatment, the patient's spirit improved, cough and expectoration were relieved, sputum was clear and thin, the amount was more and more, and the discharge was smoother. The appetite improved, fatigue, chest tightness, chills, cold limbs and other symptoms were relieved, the mood was more comfortable than before, the bowel movement was 3-4 times a day, the texture was thin, and the tongue and pulse were roughly the same as before. The treatment was continued for nearly 2 months.

[0074] The results are as follows Figure 1 As shown, the chest CT was rechecked in May 2023: the soft tissue mass in the right upper lobe of the lung was significantly smaller than before (4.3cm×2.9cm). The size of the mass was reduced by 57.3% compared with the first visit, and the patient's discomfort symptoms were further improved. Treatment continued according to the previous method. In July 2023, the chest CT was rechecked, indicating that the size of the original tumor was reduced to 0.9cm×0.9cm, and the mass was reduced by 93.5% compared with the previous treatment. In January 2024, the CT was rechecked again, indicating that the size of the original tumor was reduced to 0.6cm×0.6cm, and the mass was reduced by 55.6% compared with the previous treatment. The patient has no special discomfort, is in good mental state, has good diet and sleep, and lives like a normal person.

[0075]

Case 2

[0076] Patient Wang, male, 26 years old. In April 2021, he was diagnosed with "repeated coughing and blood in sputum for more than one month". He was examined in a local hospital for lung CT: enlargement of the right hilum, soft tissue mass in the right upper lung (4.0cm×2.7 cm), multiple nodules in both lungs (the larger one has a long diameter of about 1.0 cm), and was diagnosed with "small cell lung cancer" by lung puncture pathology. The patient is relatively young, refused radiotherapy and chemotherapy, and sought treatment from traditional Chinese medicine. Current symptoms: cough, blood in sputum from time to time, fatigue, chills, sore waist, lack of warmth in the limbs, depression, general appetite and sleep, and good bowel movements. The tongue is pale and dark, with tooth marks on the edges, white and greasy fur, and a stringy and thin pulse.

[0077] Combined with the patient's medical history, symptoms, signs, tongue and pulse, the TCM diagnosis was "lung accumulation" (Western medicine diagnosis was "lung cancer"). The core pathogenesis of this case was "deficiency of the fire of the gate of life". According to the "pathogenesis", the treatment method was "warming and nourishing the fire of the gate of life". The prescription was used for treatment. The specific medications were:

[0078] 30g of Herba Agrimoniae, 6g of Cooked Aconite (pre-fried), 12g of Dried Ginger, 18g of Roasted Licorice, 30g of Raw Astragalus, 30g of Raw Chicken Gizzard Stone, 12 portions of Raw Malt, and 12 portions of Beehive.

[0079] The results are as follows Figure 2 As shown in the figure, after 14 days of treatment, the cough was relieved, the expectoration increased, there was no blood in the sputum, and the symptoms of fatigue, chills, and cold limbs were all improved. The mood was more cheerful than before, the stool was 4-5 times a day, the discharge was smooth, the sweating increased, the urination was regular, the tongue and pulse were roughly the same as before, and the spirit improved. If the effect is not changed, the above prescription will be continued with additions and subtractions, combined with acupuncture and moxibustion for more than 3 months. In August 2021, the chest CT was rechecked: the soft tissue mass in the right upper lung was smaller than before (2.75cm×2.0 cm), and multiple nodules in both lungs (the larger one was about 1.0cm in long diameter) were the same as before. The patient's confidence increased greatly, and the original treatment plan was adhered to without changing the prescription. During the period, the prescription was fine-tuned according to the discomfort symptoms, and the chest CT was rechecked once every 3 months. In February, May and August 2022, the sizes of the tumor were 2.0cm×1.2 cm, 1.3×1.0cm and 1.0cm×0.9cm respectively. The tumor has steadily shrunk, the patient is in good spirits, has no special discomfort, lives like a normal person, and is still undergoing treatment.

[0080]

Case 3

[0081] Patient Wang, male, 85 years old. On June 7, 2023, he was admitted to a local hospital for "repeated cough and chest pain for more than 2 weeks". Lung CT showed: nodular shadow in the middle lobe of the right lung, considered to be a malignant lesion (about 3.1×2.7cm in size), multiple localized high-density shadows and bone destruction in the xiphoid process, bilateral ribs and thoracic vertebrae, considered to be bone metastasis. Puncture pathology: lung adenocarcinoma. The patient is old and in poor physical condition, and may not be able to withstand radiotherapy and chemotherapy, so he seeks Chinese medicine treatment. Current symptoms: cough, sputum, fatigue, accompanied by chest pain, chills, cold limbs, poor appetite, poor sleep and easy awakening, clear and long urination, frequent getting up at night, and normal bowel movements. The tongue is pale and dark, the tongue coating is white and greasy, and the pulse is deep and stringy.

[0082] Combined with the patient's medical history, symptoms, signs, tongue and pulse, the TCM diagnosis was "lung accumulation" (Western medicine diagnosis was "lung cancer"), the basic pathogenesis was the decline of the gate of life fire, and the treatment was based on the "pathogenesis", with the main focus on "warming and nourishing the gate of life fire". This prescription was used for treatment, and the specific drugs are as follows:

[0083] 60g of Herba Agrimoniae, 12g of cooked aconite (fried first), 18g of dried ginger, 24g of roasted licorice, 45g of raw astragalus, 30g of raw chicken gizzard lining, 15g of raw malt, and 30g of beehive.

[0084] The results are as follows Figure 3 As shown in the figure, after 14 days of treatment, the patient's spirit improved, and he felt that his cough and sputum were relieved compared with before. The sputum was clear and thin, and the discharge was smooth. The symptoms of fatigue, chest pain, chills, and cold limbs were relieved. The appetite improved, the mood was comfortable, the number of times he got up at night was reduced, the bowel movement was regular, and the tongue and pulse were roughly the same as before. The effect did not change the prescription, and the treatment continued until now. During this period, CT was reviewed every 3 months, and the size of the lung tumor was reduced to. In September and December 2023, and March 2024, the size of the mass was 2.4cm×1.9 cm, 1.7×1.2cm, and 0.4cm×0.3cm, respectively, and the tumor was steadily reduced compared with the previous time. At present, the patient has no special discomfort, is in good mental state, can sleep well, and is still under treatment.

[0085] In summary, the three medical cases illustrate that the compound of the present invention is helpful in improving the symptoms, mental state, diet and sleep of cancer patients, and long-term use can continuously reduce the tumor.

[0086] Example 5 Animal Experiment

[0087] Lung cancer cell line A549 cells were injected subcutaneously into nude mice. Seven days later, when the tumor size reached about 100 mm 3 At the same time, mice were gavaged with the composition described in Example 2 every day, and divided into a low-dose group (6 g / kg) and a high-dose group (12 g / kg), and the control group was an A549 tumor group. The treatment was continued for 3 weeks, and the tumor size was measured every week.

[0088] Formula V = length (mm) × width (mm) 2 / 2.

[0089] At the end of treatment, mice were weighed, euthanized and tumor tissues were carefully removed to weigh the tumor tissues.

[0090] Results: Tumor size was observed continuously. Figure 4 As shown in Figure 2, compared with the control group, both the low-dose compound group (SSBXD-L) and the high-dose compound group (SSBXD-H) can significantly inhibit tumor size and continuously inhibit tumor growth. In addition, at the end point of administration, the results are as follows: Figure 5 and Figure 6 , the weight of mice did not change significantly. Compared with the control group (0.604±0.160g), the tumor tissue weight of the low-dose compound group (0.442±0.108g) and the high-dose compound group (0.265±0.105g) was lower, which was reduced by 26.87% and 56.16% respectively compared with the control, and the tumor size of the high-dose compound group was significantly lower than that of the control group (p<0.01). These results show that the present invention helps to inhibit tumor growth.

[0091] The above is only a specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art can easily think of changes or substitutions within the technical scope disclosed by the present invention, which should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention should be based on the protection scope of the claims.

Claims

1. A Chinese medicine composition for preventing lung cancer, characterized in that: The Chinese medicine composition is made of the following raw materials in parts by weight: 20-120 parts of herba agrimonii, 5-15 parts of cooked aconite root, 5-20 parts of dried ginger, 10-30 parts of roasted licorice root, 20-50 parts of raw astragalus, 10-50 parts of raw chicken gizzard lining, 10-80 parts of raw malt and 10-50 parts of honeycomb.

2. The anti-lung cancer Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition is made of the following raw materials in parts by weight: 30-60 parts of herba agrimonii, 6-12 parts of cooked aconite root, 9-18 parts of dried ginger, 12-24 parts of roasted licorice root, 24-45 parts of raw astragalus, 18-45 parts of raw chicken gizzard lining, 18-45 parts of raw malt and 12-36 parts of honeycomb.

3. The anti-lung cancer Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition is made of the following raw materials in parts by weight: 45 parts of herba agrimonii, 6 parts of cooked aconite root, 15 parts of dried ginger, 20 parts of roasted licorice root, 30 parts of raw astragalus, 30 parts of raw chicken gizzard lining, 30 parts of raw malt and 15 parts of honeycomb.

4. The method for preparing the anti-lung cancer Chinese medicine composition according to claim 1, characterized in that: The method comprises the following steps: (1) Add cooked aconite root to boiling water and simmer for 0.5-1 hour until the spicy sensation disappears; (2) Add the pre-soaked agrimony, dried ginger, roasted licorice, raw astragalus, raw chicken gizzard lining and beehive, bring to a boil over high heat and then simmer over low heat, finally add raw malt and continue simmering for 10-15 minutes to obtain the Chinese medicine composition.

5. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of anti-lung cancer drugs.

6. An anti-lung cancer drug, characterized in that: The medicine comprises the Chinese medicine composition according to any one of claims 1 to 3 and pharmaceutically acceptable excipients.

7. The anti-lung cancer drug according to claim 6, characterized in that: The medicine is an oral preparation.

8. The anti-lung cancer drug according to claim 6, characterized in that: The medicine is in the form of decoction, pill, powder, paste, wine, granule, tablet or capsule.

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