Developable ink under imaging equipment and use method of developable ink

Abstract

The invention provides developing ink under imaging equipment and a use method, and belongs to the technical field of medical supplies. The developable ink comprises an ink base solution and tungsten powder, wherein the ink base solution comprises an acrylic resin solution and a polyurethane resin solution. The tungsten powder is introduced into the ink base solution, the ink is endowed with a developable effect, in addition, by regulating and controlling the proportion and the particle size of the tungsten powder in the ink, the stability of the ink is improved, the situation that the tungsten powder settles in the using process and consequently even distribution of the tungsten powder in the ink is affected is avoided, and the developing effect is better; in addition, the use method of the developable ink is simple, and the problems of difficult installation, high cost and the like of a developing ring in the prior art are solved.

Description

Technical Field

[0001] The invention belongs to the technical field of medical supplies and relates to an ink that can be developed under imaging equipment and a use method thereof. Background Art

[0002] Since minimally invasive treatment technology has been used in the field of medical treatment, especially in the treatment of cardiovascular diseases, interventional minimally invasive treatment has become the preferred treatment method for cardiovascular diseases. The so-called interventional minimally invasive treatment refers to surgical treatment performed by making an incision in a certain part of the patient's body with the help of X-rays and medical imaging technology, and then using interventional equipment to reach the lesion site. In cardiovascular interventional treatment surgery, it is necessary to use a catheter to establish an interventional device to reach the lesion to implement device placement or use the device to perform surgical actions. How to judge whether the interventional device has accurately reached the patient's lesion or the required position during the operation is a prerequisite for the smooth progress of the operation. Therefore, the cardiovascular interventional treatment catheter must be used with the help of a metal ring or sheet that is not transparent to X-rays to show the exact position of the catheter in the body.

[0003] As we all know, the X-ray opacity of metals is mainly determined by their density. The higher the density, the better the developing property, and vice versa. Among all metals, the density from high to low is osmium (22.57g / cm3), iridium (22.42g / cm3), platinum (21.35g / cm3), tungsten (19.3g / cm3), gold (18.88g / cm3), and tantalum (16.65g / cm3). At present, the developing ring used in the catheter for cardiovascular interventional treatment is mainly platinum-iridium (PTIR10) alloy, which is a precious metal with high cost. Using developing ink is conducive to reducing costs.

[0004] In addition, regarding the installation method of the developing point, method 1: conventional interventional catheters are composed of an inner lining layer, a metal braided layer, and an outer tube layer, wherein the inner lining layer and the outer tube layer are both polymer materials, and the three are compounded together by heat sealing. The developing ring is clamped between the inner lining layer and the outer tube layer during the compounding process. Method 2: squeeze the metal developing ring to make it smaller and fix it on the tube body; and some single-layer tubes, that is, catheters without an inner lining layer or a metal braided layer, only an outer tube layer, such as central venous catheters, biliary drainage tubes, etc., these tubes do not have a heat sealing process during the production process, and the developing ring cannot be clamped in the tube body; nor can the metal developing ring be squeezed on the tube body, because this single-layer tube is generally very soft, and metal extrusion can easily cause the inner diameter of the tube body to decrease; so this type of catheter is not very convenient to install using conventional developing point methods. The printing or spraying of ink is not limited by the product structure. Regardless of the structure of the tube body, the ink can be printed or sprayed on the outer surface of the tube body, which is more convenient to use.

[0005] Chinese invention patent application CN112143281A discloses an ink composition that can be developed under X-rays, comprising a resin carrier, a developer powder and a solvent, wherein the developer powder is composed of copper, lead sulfate, barium sulfate, calcium carbonate and aluminum hydroxide powder, and the developer powder has the property of blocking or absorbing X-rays, so that the ink is used to print patterns or texts on the surface of documents or objects, so that the patterns or texts can be developed and detected under X-rays. However, the composition of the developer powder is relatively complex. Summary of the invention

[0006] In view of the problems existing in the prior art, the present invention provides an ink that can be developed under imaging equipment and a method for using the same. The present invention introduces tungsten powder into the ink base liquid to give the ink a developable effect. In addition, by regulating the proportion and particle size of the tungsten powder in the ink, the ink stability is improved to avoid its sedimentation during use and affect its uniform distribution in the ink, thereby achieving a better developing effect. In addition, the method for using the developable ink is simple, and the problems of difficult installation of the developing ring, high cost and complex composition of the developing powder in the prior art are overcome.

[0007] To achieve the above object, the technical solution of the present invention is as follows:

[0008] The invention provides an ink developable under imaging equipment, comprising an ink base liquid and tungsten powder, wherein the ink base liquid comprises an acrylic resin liquid and a polyurethane resin liquid.

[0009] Preferably, the composition comprises, by weight: 20-30 parts of acrylic resin liquid, 20-30 parts of polyurethane resin liquid and 25-35 parts of tungsten powder.

[0010] More preferably, the mixture comprises, by weight: 20-25 parts of acrylic resin liquid, 25-30 parts of polyurethane resin liquid and 30-35 parts of tungsten powder.

[0011] Furthermore, the purity of the tungsten powder is greater than 99.9%, and the particle size is greater than 300 meshes.

[0012] The developable ink composition of the present invention further comprises: an auxiliary agent; the auxiliary agent comprises one or more of a diluent, a defoaming agent and a leveling agent.

[0013] Preferably, the composition comprises, by weight: 20-25 parts of acrylic resin liquid, 25-30 parts of polyurethane resin liquid, 30-35 parts of tungsten powder, 10-20 parts of diluent, 1-4 parts of defoaming agent, and 0.5-1 parts of leveling agent.

[0014] Furthermore, the diluent is deionized water; the defoaming agent is an organic silicon defoaming agent; and the leveling agent is an acrylic leveling agent or an organic silicon leveling agent.

[0015] The present invention also provides a method for using any of the above-mentioned developable inks, wherein the developable ink is attached to the outer surface of the catheter by printing or spraying, and then ordinary transparent ink is printed or sprayed on the outer layer of the developable ink to completely cover the developable ink;

[0016] Or the developable ink is attached to the outer surface of the inner tube by printing or spraying, and then a layer of outer tube is compounded on the outer surface thereof, that is, the developable ink is coated between the inner tube and the outer tube.

[0017] Furthermore, the developable ink is consistent with a common transparent ink base liquid.

[0018] Compared with the prior art, the present invention has the following beneficial effects:

[0019] (1) The present invention uses tungsten powder and ink base liquid to give the ink the function of being able to be developed under imaging equipment, solving the problems of difficult installation of developing rings, high costs, and complex composition of developing powder in X-ray technology;

[0020] (2) The use of tungsten powder and ink base liquid, high-purity, small-particle tungsten powder, improves the unevenness caused by the rapid sedimentation of tungsten powder during the printing process, and improves the stability of the ink;

[0021] (3) The developable ink of the present invention can be used in various ways. Compared with the installation of a developing ring, the developable ink can be used by printing or spraying, which is simpler to operate. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 A cross-sectional schematic diagram of a method for using the developable ink of the present invention;

[0023] Figure 2 A schematic cross-sectional view of a second method for using the developable ink of the present invention;

[0024] Figure 3 This is a physical picture of each ink in use in Examples 4 and 5 of the present invention;

[0025] Figure 4 This is a diagram showing the development effect of each ink of Examples 4 and 5 of the present invention under X-ray;

[0026] Explanation of the accompanying drawings: 1—developable ink; 2—ordinary ink; 3—catheter body; 31—inner catheter body; 32—outer catheter body; 5—catheter body; 6—developing point; 7—developing point; 8—developing point; 9—catheter body; 10—developing point. DETAILED DESCRIPTION

[0027] The following will describe the embodiments of the present invention in detail with reference to the accompanying drawings and examples. It is particularly noted that in order to more clearly illustrate the method of using the ink, the accompanying drawings only show the positional relationship between the ink and the catheter when in use, and the actual ink thickness and the catheter wall thickness are not limited by the size and proportion of the accompanying drawings. It will be understood by those skilled in the art that the following examples are only used to illustrate the present invention and should not be regarded as limiting the scope of the present invention. If no specific conditions are specified in the examples, the conventional conditions are followed. If the manufacturer of the reagents or instruments used is not specified, they are all conventional products that can be purchased commercially.

[0028] The components used in the comparative examples of the present invention are as follows:

[0029] Acrylic resin liquid was purchased from Hangzhou Hemeng Chemical Co., Ltd., model: RD-300;

[0030] Polyurethane resin liquid was purchased from Hangzhou Hemeng Chemical Co., Ltd., model: W-6110;

[0031] Diluent: deionized water;

[0032] Defoaming agent: methyl silicone oil;

[0033] Leveling agent: alkyl modified organosiloxane (model: MONENG-1060).

[0034] Example 1

[0035] An ink that can be developed under imaging equipment, comprising: 30 parts of acrylic resin liquid, 20 parts of polyurethane resin liquid, 35 parts of tungsten powder (purity 99.9%, particle size: 300 mesh), 15 parts of diluent, 2 parts of defoaming agent, and 1 part of leveling agent;

[0036] The preparation method is as follows:

[0037] Step 1: Weigh acrylic resin liquid, polyurethane resin liquid, diluent and leveling agent according to the above composition, add them into a stirring kettle respectively, stir at high speed for 20-35 minutes, and control the stirring speed at 500-1000r / min to obtain initial ink.

[0038] Step 2: Before printing the ink, add tungsten powder and defoamer to the initial ink, stir at high speed for 10 minutes, and control the stirring speed at 200-300r / min to obtain the developing ink.

[0039] Embodiment 2:

[0040] An ink that can be developed under imaging equipment, composed of: 20 parts of acrylic resin liquid, 30 parts of polyurethane resin liquid, 35 parts of tungsten powder (purity 99.9%, particle size: 300 mesh), 20 parts of diluent, 1 part of defoamer, and 0.5 part of leveling agent; the preparation method is consistent with that of Example 1.

[0041] Embodiment 3:

[0042] An ink that can be developed under imaging equipment, comprising: 25 parts of acrylic resin liquid, 25 parts of polyurethane resin liquid, 25 parts of tungsten powder (purity 99.9%, particle size: 300 mesh), 10 parts of diluent, 4 parts of defoaming agent, and 1 part of leveling agent; the preparation method is consistent with that of Example 1.

[0043] Comparative Example 1:

[0044] An ink that can be developed under imaging equipment, comprising: 25 parts of acrylic resin liquid, 10 parts of polyurethane resin liquid, 50 parts of tungsten powder (purity 99.9%, particle size: 300 mesh), 15 parts of diluent, 2 parts of defoaming agent, and 1 part of leveling agent; the preparation method is consistent with that of Example 1.

[0045] Comparative Example 2:

[0046] An ink that can be developed under imaging equipment, comprising: 30 parts of acrylic resin liquid, 20 parts of polyurethane resin liquid, 35 parts of tungsten powder (purity 99.9%, particle size: 100 mesh), 15 parts of diluent, 2 parts of defoaming agent, and 1 part of leveling agent; the preparation method is consistent with that of Example 1.

[0047] The developing ink of the present invention has the following use method:

[0048] Method of use: Figure 1 As shown, the developer ink 1 is applied to a designated position on the tube body 3 (with a thickness of 5-10 μm), and then a layer of ordinary ink 2 (with a spraying thickness of 5-10 μm) is applied on the developer ink to fix it.

[0049] Method 2: Figure 2 As shown, the developer ink 1 is applied to a designated position on the inner catheter body 31 (with a thickness of 5-10 μm), and a layer of catheter is compounded on the outside, namely the outer catheter body 32, that is, the developer ink is applied between the two layers of catheter body.

[0050] Embodiment 4:

[0051] like Figure 3 As shown, the catheter body 5 is a medical catheter added with 20% barium sulfate (developer powder), the developing point 6 is printed with 5.25μm developable ink prepared in Example 1 according to method 2, and the most commonly used developing ring for medical catheters made of platinum-iridium alloy is placed at the developing point 7.

[0052] Embodiment 5:

[0053] like Figure 3As shown, the catheter body 9 is a medical catheter without any additives, the developing point 8 is a 5.18 μm developable ink prepared in Example 1 by printing according to method 2; the developing point 10 is a 5 μm developable ink prepared in Comparative Example 1.

[0054] Effect example: ink performance test

[0055] (1) Bottom deposition in 20 minutes: Take 0.5g of developable ink and add it to 50mL of water, stir it to make it fully dispersed, let it stand for 20 minutes, and observe the bottom ink deposition; this parameter reflects the time it takes for the tungsten powder in the ink to be evenly dispersed. If there is too much bottom deposition, the tungsten powder will accumulate more easily during the printing process, resulting in uneven ink, that is, the stability of the ink will be worse;

[0056] (2) Adhesion of ordinary ink without coating: The test method is to use a fingernail to gently scrape the ink surface to see if the ink falls off;

[0057] (3) Adhesion of coated ordinary ink: the same as the test method of test 2.

[0058] The above test results are shown in Table 1.

[0059] Table 1 Ink deposition and adhesion test results

[0060] 20 minutes bottom sedimentation Does not cover the adhesion of ordinary inks Adhesion of coating ordinary ink Example 1 Small amount of deposition Ink falls off in large quantities No shedding Example 2 Small amount of deposition Ink falls off in large quantities No shedding Example 3 Small amount of deposition Ink falls off in large quantities No shedding Comparative Example 1 Large amount of deposition Ink falls off in large quantities No shedding Comparative Example 2 Large amount of deposition Ink falls off in large quantities No shedding

[0061] From the test results, compared with Example 1, the stability of the developing ink in Comparative Examples 1 and 2 is insufficient, that is, the tungsten powder particles are too large and the proportion of tungsten powder is too large, which will cause the tungsten powder particles to be unable to suspend in the resin liquid for a long time, and the stability of the ink is insufficient. The relative proportions of the two resin liquids are different, which has little effect on the stability of the ink. In addition, the addition of tungsten powder will affect the adhesion of the ink, and the adhesion of the ink will not increase due to the reduction of the proportion of tungsten powder. The adhesion of the developing ink containing different proportions of tungsten powder is insufficient, and after being coated with a layer of ordinary ink, the problem of insufficient adhesion can be improved.

[0062] (4) Development effect: The development effect of each development point of Example 4 and Example 5 was observed under X-ray. The results are as follows: Figure 4 The accompanying drawings are marked with Figure 3 The developing points 6 and 8 are the developing ink prepared in Example 1, and the developing point 10 is the developing effect of the developing ink prepared in Comparative Example 1. The developing point 7 is the developing effect of the most common developing ring in the medical field. It can be seen that the developing effect of the ink with tungsten powder added is basically the same as that of the current conventional developing ring, and both can be clearly distinguished from the medical catheter with the developing powder added, indicating that the developing effect of the tungsten powder ink can meet clinical needs.

[0063] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, rather than to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions of the technical solution of the present invention by ordinary technicians in this field do not deviate from the essence and scope of the technical solution of the present invention.

Claims

1. An ink developable under imaging equipment, characterized in that: The invention comprises ink base liquid and tungsten powder, wherein the ink base liquid comprises acrylic resin liquid and polyurethane resin liquid.

2. The developable ink according to claim 1, characterized in that The composition comprises, by weight: 20-30 parts of acrylic resin liquid, 20-30 parts of polyurethane resin liquid and 25-35 parts of tungsten powder.

3. The developable ink according to claim 2, characterized in that The composition comprises, by weight: 20-25 parts of acrylic resin liquid, 25-30 parts of polyurethane resin liquid and 30-35 parts of tungsten powder.

4. The developable ink according to claim 1, characterized in that The purity of the tungsten powder is greater than 99.9%, and the particle size is greater than 300 meshes.

5. The developable ink according to any one of claims 1 to 4, characterized in that: Also includes: Additives.

6. The developable ink according to claim 5, characterized in that The auxiliary agent includes one or more of a diluent, a defoamer and a leveling agent.

7. The developable ink according to claim 6, characterized in that The composition comprises, by weight: 20-25 parts of acrylic resin liquid, 25-30 parts of polyurethane resin liquid, 30-35 parts of tungsten powder, 10-20 parts of diluent, 1-4 parts of defoaming agent and 0.5-1 parts of leveling agent.

8. The developable ink according to claim 7, characterized in that The diluent is deionized water; the defoamer is an organosilicon defoamer; and the leveling agent is an acrylic leveling agent or an organosilicon leveling agent.

9. The method for using the developable ink according to any one of claims 1 to 8, characterized in that: After the developable ink is attached to the outer surface of the catheter by printing or spraying, ordinary transparent ink is printed or sprayed on the outer layer of the developable ink to completely cover the developable ink; Or the developable ink is attached to the outer surface of the inner tube by printing or spraying, and then a layer of outer tube is compounded on the outer surface thereof, that is, the developable ink is coated between the inner tube and the outer tube.

10. The method of use according to claim 9, characterized in that: The developable ink is consistent with a common transparent ink base fluid.

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