Gravity simulation device for medical experiment

Abstract

The invention relates to the field of medical equipment, and discloses a gravity simulation device for medical experiments, which comprises a driving assembly and a placement cage, the driving assembly comprises a supporting rod, a driving motor and a rotating rod piece, the supporting rod extends in the first direction, the driving motor is arranged at the top of the supporting rod, the output end of the driving motor is connected with the rotating rod piece in the second direction, and the end, in the third direction or the first direction, of the rotating rod piece is connected with a placement cage; the placement cage comprises a cage body, a fixing assembly and a detection assembly, and the fixing assembly is arranged on the inner wall of the cage body; the detection assembly is arranged opposite to the fixing assembly in the cage body; the driving motor drives the placement cage to rotate, different gravity environments can be adjusted and simulated by adjusting the output power of the driving motor, and the experimental animal is fixed by the fixing assembly, so that the problem that the experimental animal is injured due to panic movement is avoided; and the experimental animal is fixed, so that the detection assembly can more conveniently and stably monitor the states of the experimental animal in different gravity environments.

Description

Technical Field

[0001] The invention relates to the field of medical research equipment, in particular to a gravity simulation device for medical experiments. Background Art

[0002] The right level of hypergravity can have a therapeutic effect on animals with diseases. Exposing experimental animals to a hypergravity environment has been shown to be a positive treatment for diseases such as allergic asthma and rhinitis. In recent years, there has been an increasing number of studies on the effects of hypergravity on disease treatment. During experimental research, experimental animals (such as mice) need to be placed in a hypergravity environment.

[0003] However, there is no instrument on the market specifically for small animal hypergravity experiments. A few hypergravity models can only successfully establish a hypergravity environment, but cannot observe the state of small animals in a hypergravity environment. In addition, commonly used aviation hypergravity simulation instruments have problems such as complex structure, high cost, and cumbersome operation, and are not suitable for small animals such as mice. Summary of the invention

[0004] The technical problem to be solved by the present invention is: how to better simulate a hypergravity environment suitable for small animals. In order to solve the above technical problem, the present invention provides a gravity simulation device for medical experiments, which has a first direction and a second direction that intersect vertically, and includes a driving component and a placement cage;

[0005] The driving assembly comprises a support rod, a driving motor and a rotating rod, wherein the support rod is extended along a first direction, the driving motor is arranged at the top of the support rod, the output end of the driving motor is connected to the rotating rod toward the second direction, and the end of the rotating rod away from the driving motor along a third direction or the first direction is connected to the placement cage;

[0006] The placement cage includes a cage body, a fixing component and a detection component. The cage body is fixedly connected to the rotating rod. The fixing component is arranged on the inner wall of the cage body and is used to fix the experimental animal. The detection component is arranged in the cage body opposite to the fixing component and is used to detect and record the status of the experimental animal.

[0007] Preferably, the rotating rod comprises a plurality of telescopic rods with adjustable fixed telescopic lengths, and the plurality of telescopic rods are symmetrically arranged around the rotation axis of the output end of the driving motor.

[0008] Preferably, the fixing assembly comprises a silicone base plate, the four corners of which are provided with buckles for restraining the limbs of the experimental animal, and the middle of the silicone base plate is provided with a waist buckle for restraining the body of the experimental animal.

[0009] Preferably, the end of the buckle is provided with a movable bolt opening with an adjustable ring size, and the distance of the movable bolt opening relative to the silicone base plate is adjustable; one end of the waist buckle is fixedly connected to the silicone base plate, and the other end of the waist buckle is snap-connected to the silicone base plate.

[0010] Preferably, the detection component includes a camera and an infrared thermometer, and the camera and the infrared thermometer are both fixed to the top of the cage by bolts. The camera is used to monitor and record the activity status of the experimental animal, and the infrared thermometer is used to monitor changes in the body temperature status of the experimental animal.

[0011] Preferably, the cage body is provided with a detachable observation window on a side away from the driving motor, and the observation window is provided with a plurality of observation holes penetrating the observation window in parallel.

[0012] Preferably, the support rod is L-shaped, and the drive motor is fixedly arranged on the cross bar at the top of the support rod; and a support plate is fixedly connected to the bottom of the support rod.

[0013] Preferably, a commutator and a transmission are disposed on the top surface of the support plate, and both the commutator and the transmission are electrically connected to the drive motor.

[0014] Preferably, the rotation speed of the driving motor is 5 rpm to 100 rpm.

[0015] Compared with the prior art, the gravity simulation device for medical experiments provided in the embodiment of the present invention has the following beneficial effects:

[0016] In the present invention, a driving motor drives the placement cage to rotate. By adjusting the output power of the driving motor, the centrifugal force exerted on the experimental animals in the placement cage can be adjusted, thereby simulating different gravity environments. The experimental animals in the placement cage are fixed by setting a fixing component to avoid injuries caused by panic and movement of the experimental animals. The fixing of the experimental animals also enables the detection component to more conveniently and stably monitor the status of the experimental animals in different gravity environments. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 is a stereoscopic view of the present invention;

[0018] Figure 2 It is a structural view of a placement cage of the present invention.

[0019] In the figure: 1, driving assembly; 11, supporting rod; 12, driving motor; 13, rotating rod; 131, telescopic rod;

[0020] 2. Placement cage; 21. Cage body; 22. Fixing assembly; 221. Silicone base plate; 222. Bolt; 2221. Movable bolt mouth; 223. Waist buckle; 23. Detection assembly; 231. Camera; 232. Infrared thermometer; 24. Observation window;

[0021] 3. Support plate; 31. Commutator; 32. Transmission. DETAILED DESCRIPTION

[0022] The specific implementation of the present invention is further described in detail below in conjunction with the accompanying drawings and examples. The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention.

[0023] like Figure 1 and Figure 2 As shown, a preferred embodiment of the present invention provides a gravity simulation device for medical experiments, which has a first direction and a second direction that intersect vertically, and includes a driving assembly 1 and a placement cage 2;

[0024] The driving assembly 1 includes a support rod 11, a driving motor 12 and a rotating rod 13. The support rod 11 is extended along a first direction, the driving motor 12 is arranged at the top of the support rod 11, the output end of the driving motor 12 is connected to the rotating rod 13 in a second direction, and the end of the rotating rod 13 away from the driving motor 12 in a third direction or the first direction is connected to the placement cage 2;

[0025] The placement cage 2 includes a cage body 21, a fixing component 22 and a detection component 23. The cage body 21 is fixedly connected to the rotating rod 13. The fixing component 22 is arranged on the inner wall of the cage body 21, and the fixing component 22 is used to fix the experimental animal; the detection component 23 is arranged opposite to the fixing component 22 in the cage body 21, and the detection component 23 is used to detect and record the status of the experimental animal.

[0026] The first direction is Z, the second direction is X, and the third direction is Y. Specifically, in the process of conducting experiments on experimental animals, multiple animals that meet the experimental requirements are first selected, and mice are preferably selected; after selecting the mice, the mice are grouped into an atmosphere control group and an implementation group, and then the mice of the multiple experimental groups are placed in the placement cage 2, and the mice are fixed to the bottom of the placement cage 2 by the fixing component 22, and the various detection components in the detection component 23 are started to aim at the mice, and the various detection components in the detection component 23 record the status of the experimental mice throughout the process; then the drive motor 12 is started, and the drive motor 12 drives the rotating rod 13 to rotate, and the placement cage 2 rotates with the rotating rod 13. The different speeds of the drive motor 12 can create different gravity environments for the mice in the placement cage 2, which is convenient for experimenters to explore the effects of different gravity on experimental mice.

[0027] In some embodiments, the rotating rod 13 includes a plurality of telescopic rods 131 with adjustable fixed telescopic lengths, and the plurality of telescopic rods 131 are symmetrically arranged around the rotation axis of the output end of the driving motor 12 .

[0028] Specifically, the length of the telescopic rod 131 is adjustable, and the adjustment of the rotation speed of the drive motor 12 can achieve a wider range of gravity effect adjustment, thereby increasing the scope of application of the entire device, and the experimenter can test the effect of gravity on experimental mouse diseases within a larger gravity range. In addition, for experimental animals of different sizes, the size of the placement cage 2 is also different, and the length of the telescopic rod 131 can be adjusted accordingly, so that the height of the placement cage 2 meets the space requirements for rotation. In a specific embodiment, the length adjustment range of the telescopic rod 131 is 20 cm to 80 cm.

[0029] Furthermore, different telescopic rods 131 correspond to different numbers of placement cages 2. Since experimental mice are placed in the placement cages 2, the layout structure of an even number of placement cages 2 is more reasonable and reliable in weight distribution than the layout structure of an odd number of placement cages 2. The drive motor 12 can better drive the placement cages 2 to rotate. In a specific embodiment, four placement cages 2 and four rotating rods 13 are provided.

[0030] In some embodiments, the fixing assembly 22 includes a silicone base plate 221 , the four corners of which are provided with buckles 222 for restraining the limbs of the experimental animal, and the middle of the silicone base plate 221 is provided with a waist buckle 223 for restraining the body of the experimental animal.

[0031] Specifically, the silicone bottom plate 221 can protect the experimental animals, preventing the experimental animals from being injured due to collision with the cage body 21 during the rotation of the placement cage 2, thereby avoiding the problem of inaccurate experimental data caused by injuries. The buckle 222 and the waist buckle 223 can limit the movement of the limbs and trunk of the experimental animals, further avoiding injuries caused by the experimental animals' movement, and also facilitating the monitoring effect of the various detection components in the detection assembly 23 on the status of the experimental animals.

[0032] In some embodiments, the end of the bolt buckle 222 is provided with a movable bolt opening 2221 with an adjustable ring size, and the distance between the movable bolt opening 2221 and the silicone base plate 221 is adjustable; one end of the waist buckle 223 is fixedly connected to the silicone base plate 221, and the other end of the waist buckle 223 is snap-connected to the silicone base plate 221. Specifically, the movable bolt opening 2221 can better fit the limbs of experimental animals of different sizes and can better fix the limbs of experimental animals. The snap-connection between one end of the waist buckle 223 and the silicone base plate 221 is also to adapt to the fixation of experimental animals of different body sizes. In a specific embodiment, the waist buckle 223 is provided with a first latching tooth, the silicone base plate 221 is provided with a first latching hole corresponding to the waist buckle 223, and a second latching tooth is provided in the first latching hole corresponding to the first latching tooth. Similarly, a third latch tooth is provided on the bolt buckle 222, a second latch hole is provided on the silicone base plate 221 corresponding to the bolt buckle 222, and a fourth latch tooth is provided in the second latch hole corresponding to the third latch tooth; in addition, a third latch hole is also provided on the bolt buckle 222, and the end of the bolt buckle 222 passes through the third latch hole to form a movable bolt opening 2221, at which time the third latch tooth is buckled and connected to the third latch hole.

[0033] In some embodiments, the detection component 23 includes a camera 231 and an infrared thermometer 232. The camera 231 and the infrared thermometer 232 are both fixed to the top of the cage 21 by bolts. The camera 231 is used to monitor and record the activity status of the experimental animal, and the infrared thermometer 232 is used to monitor changes in the body temperature status of the experimental animal.

[0034] Specifically, the camera 231 and the infrared thermometer 232 are both electrically connected to a display assembly (not shown in the figure). The camera 231 is convenient for the experimenter to observe the state of the experimental animal during the experiment, so as to adjust the speed of the drive motor 12 at any time, and the infrared thermometer 232 can continuously monitor the body temperature of the experimental animal, and feedback the changes in the body state of the experimental animal under different gravity environments through the changes in the body temperature of the experimental animal. In some other embodiments, other detection equipment can also be set on the body of the experimental animal to obtain more detailed information such as injected blood pressure. In addition, the connection between the camera 231 and the infrared thermometer 232 and the display assembly can be achieved through a wireless connection.

[0035] In some embodiments, the cage body 21 is provided with a detachable observation window 24 on the side away from the driving motor 12, and the observation window 24 is provided with a plurality of observation holes penetrating the observation window 24 in parallel. Specifically, the detachable design of the observation window 24, on the one hand, makes it more convenient and quick to take and put the experimental animal, and on the other hand, in some special cases, the observation window 24 can be directly removed, so that the observation of the experimental animal is more direct.

[0036] In some embodiments, the support rod 11 is L-shaped, and the drive motor 12 is fixedly arranged at the crossbar at the top of the support rod 11; the bottom of the support rod 11 is fixedly connected with the support plate 3. Further, the top surface of the support plate 3 is provided with a commutator 31 and a transmission 32, and the commutator 31 and the transmission 32 are both electrically connected to the drive motor 12. The commutator 31 can adjust the rotation direction of the drive motor 12, and can also display in real time whether the rotation direction of the placement cage 2 is counterclockwise or clockwise at this time, so that the experimenter can adjust the working state of the drive motor 12 in time, and the transmission 32 can adjust the rotation speed of the drive motor 12. In some embodiments, the rotation speed of the drive motor 12 is 5 rpm to 100 rpm, and the preferred rotation speed is 60 rpm.

[0037] In summary, the embodiment of the present invention provides a gravity simulation device for medical experiments, which can apply gravity effects to multiple experimental animals at the same time, and can also adjust the gravity effect by adjusting the rotational speed of the drive motor 12, so as to observe the state of the animals within a larger gravity range. The detection component 23 can continuously monitor and feedback the state of the experimental animals, making it convenient for the experimenter to control the state of the experimental animals, and the setting of the fixing component 22 can well adapt to and fix experimental animals of different sizes, thereby increasing the scope of application of the device.

[0038] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and substitutions can be made without departing from the technical principles of the present invention. These improvements and substitutions should also be regarded as the scope of protection of the present invention.

Claims

1. A gravity simulation device for medical experiments, having a first direction, a second direction and a third direction which are perpendicular to each other, characterized in that: Includes a drive assembly and a placement cage; The driving assembly comprises a support rod, a driving motor and a rotating rod, wherein the support rod is extended along a first direction, the driving motor is arranged at the top of the support rod, the output end of the driving motor is connected to the rotating rod toward the second direction, and the end of the rotating rod away from the driving motor along a third direction or the first direction is connected to the placement cage; The placement cage includes a cage body, a fixing component and a detection component. The cage body is fixedly connected to the rotating rod. The fixing component is arranged on the inner wall of the cage body and is used to fix the experimental animal. The detection component is arranged in the cage body opposite to the fixing component and is used to detect and record the status of the experimental animal.

2. The gravity simulation device for medical experiments according to claim 1, characterized in that: The rotating rod comprises a plurality of telescopic rods with adjustable fixed telescopic lengths, and the plurality of telescopic rods are symmetrically arranged around the rotation axis of the output end of the driving motor.

3. The gravity simulation device for medical experiments according to claim 1, characterized in that: The fixing assembly comprises a silicone base plate, the four corners of which are provided with buckles for restraining the limbs of the experimental animal, and the middle of the silicone base plate is provided with a waist buckle for restraining the body of the experimental animal.

4. The gravity simulation device for medical experiments according to claim 3, characterized in that: The end of the buckle is provided with a movable bolt opening with an adjustable ring size, and the distance of the movable bolt opening relative to the silicone base plate is adjustable; one end of the waist buckle is fixedly connected to the silicone base plate, and the other end of the waist buckle is buckled with the silicone base plate.

5. The gravity simulation device for medical experiments according to claim 1, characterized in that: The detection component includes a camera and an infrared thermometer, both of which are fixed to the top of the cage by bolts. The camera is used to monitor and record the activity status of the experimental animals, and the infrared thermometer is used to monitor changes in the body temperature status of the experimental animals.

6. The gravity simulation device for medical experiments according to claim 1, characterized in that: The cage body is provided with a detachable observation window on a side away from the driving motor, and the observation window is provided with a plurality of observation holes penetrating the observation window in parallel.

7. The gravity simulation device for medical experiments according to claim 1, characterized in that: The support rod is L-shaped, and the drive motor is fixedly arranged on the cross bar at the top of the support rod; the bottom of the support rod is fixedly connected with a support plate.

8. The gravity simulation device for medical experiments according to claim 7, characterized in that: A commutator and a transmission are disposed on the top surface of the support plate, and both the commutator and the transmission are electrically connected to the drive motor.

9. The gravity simulation device for medical experiments according to claim 1, characterized in that: The rotation speed of the driving motor is 5 rpm to 100 rpm.

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