Parathyroid perfusion storage device
By designing parathyroid perfusion storage equipment, including storage boxes, perfusion fluid circulation system and control system, the problem of poor protection effect of parathyroid extracorporeal preservation equipment in the prior art is solved, and effective in vitro preservation and structural protection of parathyroid gland is achieved.
Patent Information
- Application Number
- CN202510051667.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2025-01-14
- Publication Date
- 2025-04-18
- Estimated Expiration
- 2045-01-14
AI Technical Summary
In the prior art, the external preservation equipment for parathyroid glands is difficult to effectively protect the parathyroid glands, and there is a lack of equipment designed specifically for external preservation of parathyroid glands.
A parathyroid perfusion storage device is designed, including a parathyroid storage box, a perfusion fluid circulation system and a control system. The perfusion liquid circulation system communicates with the storage box through the inlet tube, the indwelling needle and the return tube to supply perfusion fluid to the ex vivo parathyroid gland. The control system is used to monitor and regulate the flow rate, pressure and temperature of the perfusion fluid.
Effective in vitro preservation of parathyroid glands is achieved, avoiding collisions between parathyroid glands during preservation, and ensuring its structural stability and reliability of preservation.
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Figure CN119453178B_ABST
Abstract
Description
Technical Field
[0001] The invention relates to the technical field of human organ storage, in particular to parathyroid gland perfusion storage equipment. Background Art
[0002] Generally speaking, the parathyroid gland is an important gland in the human body and one of the endocrine glands in the human body. Parathyroid transplantation is a technology that protects or restores the function of the patient's parathyroid glands during thyroid surgery. Parathyroid transplantation requires the design of in vitro preservation technology. The in vitro preservation equipment of parathyroid glands in the existing technology is difficult to effectively protect the parathyroid glands, and the parathyroid glands are small in size and are not easy to preserve in vitro. There is also a lack of equipment specifically designed for in vitro preservation of parathyroid glands. Summary of the invention
[0003] In order to solve the above problems, the present invention proposes a parathyroid perfusion storage device, which can realize the in vitro storage of parathyroid glands and can effectively protect the parathyroid glands.
[0004] To achieve the above object, the technical solution adopted by the present invention is:
[0005] Parathyroid gland perfusion storage device, including
[0006] A parathyroid gland storage box, wherein the parathyroid gland storage box has a space for placing the parathyroid glands;
[0007] a perfusion liquid circulation system, wherein the perfusion liquid circulation system is connected with the isolated parathyroid glands stored in the parathyroid gland storage box through a liquid inlet tube, an indwelling needle and a return tube to supply perfusion liquid to the isolated parathyroid glands;
[0008] A control system, wherein the control system is electrically connected to the components of the perfusion liquid circulation system, and the control system is used to receive working state signals of the components of the perfusion liquid circulation system and send control instructions to the components of the perfusion liquid circulation system according to the working state signals.
[0009] Preferably, the perfusion liquid circulation system includes two circulation pipelines, wherein
[0010] The first circulation pipeline includes a first perfusion pump, a debubbling module, an oxygen exchange module, a first pressure gauge and a first flow meter which are sequentially arranged on the pipeline from the reflux direction to the delivery direction;
[0011] The second circulation pipeline includes a second perfusion pump, a debubble module, a second pressure gauge and a second flow meter which are arranged in sequence from the reflux direction to the delivery direction on the pipeline.
[0012] Preferably, the first circulation pipeline and the second circulation pipeline share a return pipe, and the return pipe is provided with a thermometer for detecting the temperature of the returning perfusion fluid, and the thermometer is electrically connected to the control system.
[0013] Preferably, the parathyroid storage box has several groups of slide columns and thyroid type simulation mechanisms inside, and the thyroid type simulation mechanism includes several storage cages. The storage cages include two sliding rings and several protective plates. The sliding rings are mounted on the outside of the slide columns. The protective plates are divided into upper protective plates and lower protective plates, wherein the upper end of the upper protective plate is hinged to the upper sliding ring, and the lower end of the lower protective plate is hinged to the lower sliding ring. The number of the upper protective plates and the lower protective plates are the same and they are opposite to each other. The ends of each opposite upper protective plate and lower protective plate are hinged to each other through a protective plate hinge structure, so that the storage cage forms a retractable cage-like structure.
[0014] Preferably, the lower sliding ring in the storage cage is fixed on the slideway column, and the upper sliding ring is slidably connected to the slideway column.
[0015] Preferably, a limiting structure is installed on the slide column to limit the height position of the sliding ring above.
[0016] Preferably, the limiting structure is an elastic buckle that can be retracted into the interior of the slideway column.
[0017] Preferably, a 4-petal-shaped protective box is provided inside each thyroid-type simulation mechanism on the slide column.
[0018] Preferably, the method for using the parathyroid perfusion storage device is as follows:
[0019] The control system obtains the working status of the perfusion liquid circulation system so that the information includes within the preset range:
[0020] Obtaining the pressure of the perfusion fluid by means of a first pressure gauge and a second pressure gauge, and if the pressure exceeds the preset range, adjusting the flow rate of the perfusion fluid by means of a perfusion pump; wherein the preset range is 60-80 mmHg in the first time period and 160-180 mmHg in the second time period;
[0021] The first perfusion pump of the first circulation pipeline perfuses once every 18 hours for 40 minutes. The second perfusion pump of the second circulation pipeline replaces fresh perfusion fluid every 18 hours, and the perfusion fluid delivery rate is 0.370 ml / min.
[0022] The beneficial effects of using the present invention are:
[0023] The parathyroid perfusion system disclosed in the present invention utilizes the first perfusion passage and the second perfusion passage to transport nutrient solution, and adjusts the flow rate by controlling the rotation speed of the peristaltic pump, thereby maintaining constant pressure perfusion; for example, by setting the perfusion pressure, if the pressure exceeds the threshold, the pump operation is stopped immediately, and the perfusion pressure is stabilized at the set value by controlling the peristaltic pump; at the same time, the control module can also detect the perfusion liquid temperature in real time, and if the temperature is too high, an alarm is given. In addition, the control module can also have a timing function, and a segmented perfusion mode can be set, so that multiple constant pressure perfusion stages and the corresponding duration of each perfusion stage can be set at the same time. The present invention can regulate the flow rate, pressure and temperature of two independent perfusion tubes in real time, and can also save each parameter during the operation in real time, with strong stability and repeatability.
[0024] In addition, when the thyroid type simulation mechanism is used to preserve the parathyroid glands, if the parathyroid protection box is not locked, the parathyroid glands will become free under the action of the preservation fluid. The freedom will cause collisions between the parathyroid glands, which will damage the structure of the parathyroid glands and be detrimental to the preservation of the parathyroid glands. The thyroid type simulation mechanism can prevent the parathyroid glands from colliding with each other during the preservation process, which is beneficial to the preservation of the parathyroid glands from a mechanical point of view. BRIEF DESCRIPTION OF THE DRAWINGS
[0025] Figure 1 It is a schematic diagram of the parathyroid perfusion storage device of the present invention.
[0026] Figure 2 for Figure 1 Schematic diagram of the coordination between the middle slide column and the sliding ring.
[0027] Figure 3 Schematic diagram of the cooperation between the slide column and the sliding ring.
[0028] Figure 4 It is a schematic diagram of the cooperation between the slide column and the sliding ring in another state.
[0029] Figure 5 Schematic diagram of the coordination between the slide column and the parathyroid gland placement mechanism.
[0030] Figure 6 A schematic diagram of a protection box.
[0031] Figure 7 Axial schematic diagram of the parathyroid perfusion storage device.
[0032] Reference numerals include:
[0033] 1-control system, 2-first perfusion pump, 3-debubble module and oxygen exchange module, 4-first pressure gauge, 5-first flow meter, 6-second perfusion pump, 7-debubble module, 8-second pressure gauge, 9-second flow meter, 10-thermometer, 11-reflux pipe, 12-second liquid inlet pipe, 13-first liquid inlet pipe, 14-slide column, 141-elastic buckle, 15-thyroid type simulation mechanism, 151-sliding ring, 152-protective sheet, 153-protective sheet hinge structure, 16-parathyroid storage box, 17-protective box, 18-protective box, 19-box, 20-box door. DETAILED DESCRIPTION
[0034] In order to make the purpose, technical solution and advantages of the technical solution more clear, the technical solution is further described in detail below in conjunction with specific implementation methods. It should be understood that these descriptions are only exemplary and are not intended to limit the scope of the technical solution.
[0035] In order to solve the problem that the parathyroid glands are small in size and difficult to preserve in vitro in the prior art, and there is a lack of equipment specifically designed for the preservation of parathyroid glands in vitro, such as Figure 1 As shown, this embodiment proposes a parathyroid perfusion storage device, which can achieve in vitro storage of the parathyroid glands and can provide effective protection for the parathyroid glands.
[0036] Specifically, in this embodiment, the parathyroid perfusion storage device has a protective box 17 outside, and a parathyroid storage box 16 inside the protective box 17. Five slide columns 14 are arranged inside the parathyroid storage box 16, and each slide column 14 is provided with a thyroid type simulation mechanism 15. The thyroid type simulation mechanism 15 is used to simulate the state of the thyroid gland and can place the isolated parathyroid gland inside. In this embodiment, two thyroid type simulation mechanisms 15 are arranged on each slide column 14.
[0037] A control system 1 and a perfusion liquid circulation system are arranged outside the parathyroid storage box 16. Specifically, the perfusion liquid circulation system in this embodiment includes two circulating perfusion liquid circulation pipelines, wherein the first pipeline is a first liquid inlet pipe 13, and the first liquid inlet pipe 13 is provided with a first perfusion pump 2, a debubble module and an oxygen exchange module 3, a first pressure gauge 4 and a first flow meter 5 in the flow direction of the perfusion liquid. The second pipeline is a second liquid inlet pipe 12, and the second liquid inlet pipe 12 is provided with a second perfusion pump 6, a debubble module 7, a second pressure gauge 8 and a second flow meter 9 in the flow direction of the perfusion liquid. The output ends of the first liquid inlet pipe 13 and the second liquid inlet pipe 12 are respectively connected to the thyroid type simulation mechanism 15, and the perfusion liquid input through the first liquid inlet pipe 13 and the second liquid inlet pipe 12 returns to the first liquid inlet pipe 13 and the second liquid inlet pipe 12 through the reflux pipe 11 after passing through the thyroid type simulation mechanism 15, that is, the first liquid inlet pipe 13 and the second liquid inlet pipe 12 are connected to the reflux pipe 11 through a tee. A thermometer 10 is provided on the return pipe 11 .
[0038] The control system 1 is used as the main control system 1 to control the working state of all devices on the perfusion liquid circulation system and monitor the working state of all devices. In this embodiment, the control system 1 is electrically connected to the first perfusion pump 2, the debubble module and the oxygen exchange module 3, the first pressure gauge 4, the first flow meter 5, the second perfusion pump 6, the debubble module 7, the second pressure gauge 8, the second flow meter 9 and the thermometer 10. In addition, the first liquid inlet pipe 13 is also provided with a debubble module and an oxygen exchange module 3, and the second liquid inlet pipe 12 is provided with a debubble module 7, and the debubble module 7 includes a gas-liquid separator or an exhaust valve.
[0039] The above-mentioned parathyroid perfusion storage device can perform a parathyroid perfusion storage method, which includes placing an isolated parathyroid in a thyroid simulation mechanism and connecting a perfusion tube to the isolated parathyroid; starting the control system 1 to allow the perfusion fluid to enter the perfusion tube; and obtaining information about the perfusion fluid through a monitoring module. If the information exceeds a preset range, the control system 1 is used to adjust the information so that the information is within the preset range.
[0040] The perfusion tube includes a first liquid inlet tube 13, a second liquid inlet tube 12 and a return tube 11; a first connector for connecting to the isolated parathyroid gland is provided at one end of the first liquid inlet tube 13, and the other end of the first liquid inlet tube 13 is connected to the return tube 11; a second connector for connecting to the isolated parathyroid gland is provided at one end of the second liquid inlet tube 12, and the other end of the second liquid inlet tube 12 is connected to the return tube 11. The first connector and the second connector are respectively connected to the opposite ends of the isolated parathyroid gland; the perfusion pump is turned on to allow the perfusion fluid to enter the first liquid inlet tube 13 and the second liquid inlet tube 12 respectively; and the perfusion fluid is debubbled by the debubbling module 7, and the oxygen exchange module is used to maintain the oxygen content of the first liquid inlet tube 13.
[0041] The monitoring module obtains the information of the perfusion fluid so that the information is within the preset range, including: obtaining the pressure of the perfusion fluid through the pressure gauge, if the pressure exceeds the preset range, adjusting the flow rate of the perfusion fluid through the perfusion pump; wherein the preset range is 60-80 mmHg in the first time period and 160-180 mmHg in the second time period. The perfusion fluid delivery time and replacement of the perfusion fluid are controlled by the perfusion pump so that the perfusion fluid acquisition result is within the preset range; wherein the perfusion pump on the first inlet pipe 13 perfuses once every 18 hours, and the time is 40 minutes, and the perfusion pump on the second inlet pipe 12 replaces fresh perfusion fluid every 18 hours, and the perfusion fluid delivery rate is 0.370 ml / min.
[0042] The above-mentioned parathyroid perfusion storage device is described in detail below.
[0043] The control system 1 also includes a temperature controller, which can be composed of a semiconductor temperature control element, a semiconductor driving element, an aluminum plate and an NTC temperature sensor. The control system 1 can control the perfusion liquid temperature to reach a set value by sending a PWM wave to the semiconductor driving element and according to the perfusion liquid temperature collected by the NTC temperature sensor.
[0044] The parathyroid storage box 16 is used to hold the perfusion fluid, and the thyroid simulation mechanism is used to place the isolated parathyroid glands; the perfusion tube is a perfusion passage connected between the parathyroid storage box 16 and the thyroid simulation mechanism for delivering the perfusion fluid to the isolated parathyroid glands. The perfusion passage includes a first liquid inlet tube 13 and a second liquid inlet tube 12 connected between the parathyroid storage box 16 and the thyroid simulation mechanism.
[0045] Please see again Figure 1 As shown, the first liquid inlet pipe 13 of the first perfusion path in this embodiment can be formed by connecting several short tubes in sequence, and the above-mentioned first debubble module and oxygen exchange module 3, first perfusion pump 2, first flow meter 5 and first pressure gauge 4 are installed at the connection between two adjacent short tubes. Among them, the first debubble module and oxygen exchange module 3 are used to remove bubbles in the perfusion fluid and maintain the oxygen content in the perfusion fluid, the first perfusion pump 2 is used to drive the perfusion fluid into the first liquid inlet pipe 13, and the thermometer 10, the first flow meter 5 and the first pressure gauge 4 are used to monitor the temperature, flow rate and pressure of the perfusion fluid in the first liquid inlet pipe 13 respectively. The second perfusion path may include a second debubble module 7, a second perfusion pump 6, a second flow meter 9, a second pressure gauge 8 and a thermometer 10. The liquid outlet end of the second liquid inlet pipe 12 can extend into the thyroid simulation mechanism and be connected to the isolated parathyroid gland through a second connector.
[0046] In the embodiment of the present disclosure, the structure of the first perfusion passage is consistent with the structure of the second perfusion passage, except that the structures of the debubble module and the oxygen exchange module 3 are different from those of the first liquid inlet pipe 13. In the second perfusion passage, the pipe layout of the second liquid inlet pipe 12, the structures of other modules and the installation methods of each module on the second liquid inlet pipe 12 are consistent with the above-mentioned first perfusion passage, while the second perfusion pump 6 on the second liquid inlet pipe 12 has a different function from the first perfusion pump 2 on the first liquid inlet pipe 13. The function of the second perfusion pump 6 is to replace the perfusion fluid according to the set time to maintain the freshness of the perfusion fluid.
[0047] The first debubble module and the oxygen exchange module 3 and the second debubble module 7 can use gas-liquid separators, exhaust valves, etc.; the first perfusion pump 2 and the second perfusion pump 6 can use peristaltic pumps; the first flow meter 5 and the second flow meter 9 can use rotor flow meters; the first pressure gauge 4 and the second pressure gauge 8 can use mechanical pressure gauges; the first connecting piece and the second connecting piece use indwelling needles.
[0048] Specifically, the embodiment of the present disclosure may include obtaining the pressure of the perfusion fluid through a pressure gauge. If the pressure exceeds a preset range, the flow rate of the perfusion fluid is adjusted through a perfusion pump to make the pressure within the preset range; wherein the preset range makes the liquid transfer rate 0.370 ml / min. wherein the first monitoring module and the second monitoring module can respectively monitor the temperature, pressure, and flow rate of the perfusion fluid in the first liquid inlet tube 13 and the second liquid inlet tube 12. According to the monitoring data of the first monitoring module, the first control system 1 controls the pressure of the perfusion fluid in the liquid inlet tube in real time, such as the first perfusion pump 2 needs to control the infusion time, each infusion time is 20 minutes, and the liquid is replaced every 18 hours. The first perfusion fluid can be oxygen-carrying PFC liquid; the second perfusion pump 6 needs to discharge the liquid in the storage box once every 18 hours and replace it with fresh liquid; the maximum storage time of the entire device is 72 hours.
[0049] More specifically, under the action of the first perfusion pump 2, the perfusion fluid in the parathyroid placement mechanism enters the first liquid inlet tube 13, and after being debubbled by the first debubbling module 7, enters the isolated parathyroid gland from the first indwelling needle; before the perfusion fluid reaches the parathyroid gland, the first monitoring module detects the temperature, pressure, and flow rate of the perfusion fluid, and sends the detected information to the first control system 1, which compares the detected value with the preset value and adjusts the detected value to be consistent with the preset value in real time by controlling the working frequency of the first perfusion pump 2. The second perfusion fluid can be UW fluid, and the process of the second liquid inlet tube 12 is similar to it, which will not be repeated here, but the second perfusion pump 6 needs to update the perfusion fluid to keep the perfusion fluid fresh. The parathyroid perfusion system disclosed in the present invention utilizes the first perfusion passage and the second perfusion passage to transport nutrient solution, and adjusts the flow rate by controlling the rotation speed of the peristaltic pump, thereby maintaining constant pressure perfusion; for example, by setting the perfusion pressure, if the pressure exceeds the threshold, the pump operation is stopped immediately, and the perfusion pressure is stabilized at the set value by controlling the peristaltic pump; at the same time, the control system 1 can also detect the perfusion liquid temperature in real time, and if the temperature is too high, an alarm is issued. In addition, the control system 1 can also have a timing function, and a segmented perfusion mode can be set, so that multiple constant pressure perfusion stages and the corresponding duration of each perfusion stage can be set at the same time. The present invention can regulate the flow rate, pressure and temperature of two independent perfusion tubes in real time, and can also save each parameter during the operation in real time, with strong stability and repeatability.
[0050] like Figure 2-Figure 6 As shown, the thyroid type simulation mechanism 15 of the parathyroid storage box 16 includes a plurality of storage cages, and the storage cages include two sliding rings 151 and a plurality of protective sheets 152. The sliding rings 151 are mounted on the outside of the slide column 14, and the protective sheets 152 are divided into an upper protective sheet 152 and a lower protective sheet 152, wherein the upper end of the upper protective sheet 152 is hinged to the upper sliding ring 151, and the lower end of the lower protective sheet 152 is hinged to the lower sliding ring 151. The number of upper protective sheets 152 and lower protective sheets 152 is the same and they are opposite to each other. The ends of each opposite upper protective sheet 152 and lower protective sheet 152 are hinged to each other through a protective sheet hinge structure 153, so that the storage cage forms a retractable cage structure.
[0051] The lower sliding ring 151 in the storage cage is fixed on the slide column 14, and the upper sliding ring 151 is slidably connected to the slide column 14. A limiting structure is installed on the slide column 14 to limit the height position of the upper sliding ring 151. Preferably, the limiting structure is an elastic buckle 141 that can be retracted into the slide column 14. A 4-petal-shaped protective box 18 is provided inside each thyroid type simulation mechanism 15 on the slide column 14, and each petal-shaped structure can store an isolated parathyroid gland inside.
[0052] The protective sheet 152 can rotate around the sliding ring 151. Such a design can bring about the effect that when the protective sheet 152 rotates to the top of the sliding ring 151, it means that the storage cage is opened at the position where the protective sheet 152 is located, and the parathyroid gland storage box can be placed at this time. The sliding ring 151 can move up and down on the slide column 14, and the elastic buckle 141 is equipped with a spring. When the upper sliding ring 151 hits the elastic buckle 141, the inner ring of the upper sliding ring 151 applies a pressure to the elastic buckle 141. After the elastic buckle 141 is pressed, it compresses into the inside of the slideway column 14, so as to facilitate the upper sliding ring 151 to pass through the elastic buckle 141. After the upper sliding ring 151 completely passes through the elastic buckle 141, the elastic buckle 141 returns to its original state under the action of elastic force. At this time, the upper sliding ring 151 is just on the upper surface of the elastic buckle 141. The elastic buckle 141 applies a supporting force to the upper sliding ring 151, overcoming the problem of the upper sliding ring 151 falling due to gravity. In this way, the upper sliding ring 151 can be kept in this position to achieve the locking effect of the storage cage. The lower sliding ring 151 is in a fixed position, and the storage cage is tightened by the movement of the upper sliding ring 151. Here, the upper and lower sliding rings 151 of a storage cage are selected as an example, and the locking principle of the sliding rings 151 of other storage cages is the same as the principle explained here.
[0053] In the above structure, when the sliding ring 151 above a storage cage moves toward the top of the parathyroid preservation box, the upper and lower protective sheets 152 shrink inward due to the movement of the upper sliding ring 151, thereby locking the parathyroid protection box 18. The purpose of locking the parathyroid protection box 18 is that when we are preserving the parathyroid glands, if the parathyroid protection box 18 is not locked, the parathyroid glands will be free under the action of the preservation fluid, and the free movement will cause collisions between the parathyroid glands, which will damage the structure of the parathyroid glands and is not conducive to the preservation of the parathyroid glands. Therefore, the design of this device can prevent the parathyroid glands from colliding with each other during the preservation process, which is conducive to the preservation of the parathyroid glands from a mechanical point of view.
[0054] The storage cage can store four parathyroid glands, and each of the four parathyroid glands has a separate protective box 18, which can ensure that the parathyroid glands in the same storage cage will not collide. Under the locking effect of the protective sheet 152, the four parathyroid glands will not be free in the preservation solution, which enhances the stability during the preservation of the parathyroid glands and is conducive to the preservation of the parathyroid glands. Two storage cages are designed on each slide column 14, and multiple slide columns 14 are combined. Such a design can ensure that a storage box can store the number of parathyroid glands. This is more advantageous than the traditional storage device, in which most of the parathyroid glands float in the preservation solution and cannot be fixed in position, so it is impossible to determine the maximum number of parathyroid glands that can be stored in a storage box.
[0055] like Figure 7 As shown, the present protection box 17 includes a box body 19 and a door 20. The door 20 of the storage box can be opened, and the parathyroid glands can be placed in the storage cage, and then the storage cage can be manually locked. After completing the above operations, the preservation liquid is added to implement the preservation of the parathyroid glands. The middle part of the protection box 17 is the storage part, and the part behind the storage box is the control system 1 for perfusing the preservation liquid. There is an isolation device between the storage part and the control system 1, so that they do not affect each other.
[0056] The above contents are only preferred embodiments of the present invention. For ordinary technicians in this field, many changes can be made in the specific implementation methods and application scopes based on the ideas of the present technical content. As long as these changes do not deviate from the concept of the present invention, they all fall within the scope of protection of this patent.
Claims
1. Parathyroid gland perfusion storage device, characterized in that: include A parathyroid gland storage box, wherein the parathyroid gland storage box has a space for placing the parathyroid glands; a perfusion liquid circulation system, wherein the perfusion liquid circulation system is connected with the isolated parathyroid glands stored in the parathyroid gland storage box through a liquid inlet tube, an indwelling needle and a return tube to supply perfusion liquid to the isolated parathyroid glands; a control system, the control system being electrically connected to the components of the perfusion liquid circulation system, the control system being used to receive working state signals of the components of the perfusion liquid circulation system, and to send control instructions to the components of the perfusion liquid circulation system according to the working state signals; The parathyroid storage box has several groups of slide columns and thyroid type simulation mechanisms inside, and the thyroid type simulation mechanism includes several storage cages, and the storage cage includes two sliding rings and several protection sheets, and the sliding rings are sleeved on the outside of the slide column, and the protection sheets are divided into upper protection sheets and lower protection sheets, wherein the upper end of the upper protection sheet is hinged to the upper sliding ring, and the lower end of the lower protection sheet is hinged to the lower sliding ring, and the number of the upper protection sheets and the lower protection sheets are the same and opposite to each other, and the ends of each opposite upper protection sheet and lower protection sheet are hinged to each other through the protection sheet hinge structure, so that the storage cage forms a retractable cage structure; A 4-petal-shaped protective box is arranged inside each thyroid type simulation mechanism on the slide column.
2. The parathyroid gland perfusion storage device according to claim 1, characterized in that: The perfusion liquid circulation system includes two circulation pipelines, wherein The first circulation pipeline is a first liquid inlet pipe, including a first perfusion pump, a debubble module, an oxygen exchange module, a first pressure gauge and a first flow meter which are sequentially arranged on the pipeline from the reflux direction to the delivery direction; The second circulation pipeline is a second liquid inlet pipe, which includes a second perfusion pump, a debubble module, a second pressure gauge and a second flow meter which are arranged in sequence from the reflux direction to the delivery direction on the pipeline.
3. The parathyroid gland perfusion storage device according to claim 2, characterized in that: The first circulation pipeline and the second circulation pipeline share a return pipe, and a thermometer for detecting the temperature of the returning perfusion fluid is arranged on the return pipe, and the thermometer is electrically connected to the control system.
4. The parathyroid gland perfusion storage device according to claim 1, characterized in that: The lower sliding ring in the storage cage is fixed on the slideway column, and the upper sliding ring is slidably connected to the slideway column.
5. The parathyroid gland perfusion storage device according to claim 4, characterized in that: A limiting structure is installed on the slideway column to limit the height position of the sliding ring above.
6. The parathyroid gland perfusion storage device according to claim 5, characterized in that: The limiting structure is an elastic buckle that can be retracted into the interior of the slideway column.
Citation Information
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Isolated liver perfusion system and method
CN105660604A
Systems and methods for pancreatic perfusion
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