Automatic feeding system for glycerylphosphorylcholine capsule production

Abstract

The application belongs to the field of glycerophosphorylcholine production and application equipment, and particularly relates to an automatic feeding system for glycerophosphorylcholine capsule production. The automatic feeding system comprises a powder feeding device and a metering and filling device arranged below the powder feeding device. The metering and filling device comprises a metering barrel arranged in rotation and a filling seat arranged above the metering barrel. The filling seat is provided with a filling rod. The bottom of the metering barrel is provided with a metering hole matched with the filling rod. The application improves the structure of the powder feeding device and the metering and filling device on the basis of the existing automatic capsule filling machine, so that the glycerophosphorylcholine can be dried and dispersed, thereby avoiding the problem of hardening caused by the hygroscopic property of the glycerophosphorylcholine and affecting the filling effect. Meanwhile, the automatic feeding system for glycerophosphorylcholine capsule production mainly relies on the existing power structure, realizes double-function output, and is low in transformation cost and suitable for large-scale popularization and use.

Description

TECHNICAL FIELD

[0001] The application belongs to the field of glycerophosphorylcholine production and application equipment, and particularly relates to an automatic feeding system for glycerophosphorylcholine capsule production. BACKGROUND

[0002] Glycerophosphorylcholine is an intermediate of phospholipid metabolism naturally existing in the human body, existing in cells and throughout the human body, and composed of choline, glycerol and phosphoric acid in structure. It is a main storage form of choline and is recognized as a source of choline. Since it is an endogenous substance, its toxic and side effects are extremely low. After being absorbed, glycerophosphorylcholine is decomposed into choline and glycerophospholipid under the action of enzymes in the body: choline participates in the biosynthesis of acetylcholine, which is a kind of nerve trigger transmitter; glycerophospholipid is the precursor of lecithin and participates in the synthesis of lecithin. The main pharmacological effects include protecting the metabolism of choline, ensuring the synthesis of acetylcholine and lecithin in the nerve membrane, improving blood circulation, and improving cognitive and behavioral responses for patients with damaged capillary nerves in the brain.

[0003] Glycerophosphorylcholine is water-soluble, can be dissolved in methanol and ethanol, and is insoluble in chloroform, ether and oil. It has no characteristic absorption under ultraviolet-visible light. At room temperature, glycerophosphorylcholine is in a solid powder state. Therefore, glycerophosphorylcholine can be stored in capsules.

[0004] The existing glycerophosphorylcholine capsule is mainly filled and filled by a capsule automatic filling machine. The capsule automatic filling machine can realize automatic filling of glycerophosphorylcholine and realize automatic production. However, glycerophosphorylcholine has a very hygroscopic property. The relative ideal conditions for capsule filling are humidity of 35-65% and temperature of 15-25℃. If the humidity or temperature is too low, the capsule will become brittle and easily crack. If the humidity is too high, the capsule will become sticky and deformed. If the temperature is too high, the capsule will be damaged by heat. Therefore, it is difficult to effectively realize automatic filling. In order to ensure the assembly of the capsule, the temperature and humidity of the workshop are generally set according to the ideal conditions of the capsule. However, the high humidity leads to the possibility of glycerophosphorylcholine being hygroscopic and hardening in the feeding system, thereby affecting normal filling. SUMMARY

[0005] The application proposes a glycerophosphorylcholine capsule production automatic feeding system which is reasonable in design, simple in structure, convenient to process and can effectively solve the problem of glycerophosphorylcholine being hygroscopic, aiming at the technical problem of glycerophosphorylcholine being hygroscopic in the capsule automatic filling machine.

[0006] To achieve the above objectives, the technical solution adopted by the present invention is as follows: The present invention provides an automatic feeding system for the production of glycerol phosphorylcholine capsules, including a powder feeding device and a metering and filling device disposed below the powder feeding device. The metering and filling device includes a rotatably mounted metering barrel and a filling seat disposed above the metering barrel. A filling rod is disposed on the filling seat. A metering hole cooperating with the filling rod is disposed at the bottom of the metering barrel. A fixed seat is also disposed between the filling seat and the metering barrel. The filling seat is raised and lowered above the fixed seat. Both the filling seat and the fixed seat have a [missing information - likely a type of structure or feature]. The metering tank has a through hole for feeding material. A guide cover is provided at the bottom of the metering tank. The guide cover includes a top plate and a side plate located at the edge of the top plate. The side plate is inclined downward. Under the action of the side plate, the guide cover and the bottom of the metering tank form an aeration chamber. A hollow rotating platform is provided at the bottom of the metering tank. The metering tank is rotatable through the hollow rotating platform. A rotary joint is also provided at the bottom of the metering tank. The air outlet end of the rotary joint extends into the aeration chamber. Aeration columns are provided on the side plate. The aeration columns are evenly distributed on the side plate of the guide cover. Aeration holes are provided on the aeration columns.

[0007] Preferably, the top of the guide hood is also provided with a powder actuating disk. The powder actuating disk includes a rotating shaft fitted on the top of the guide hood and a distributing disk set on the top of the rotating shaft. A deflecting rod is provided on the side wall of the distributing disk. The deflecting rod is evenly distributed on the side wall of the distributing disk. An external gear ring is provided at the end of the deflecting rod away from the distributing disk. The external gear ring is fitted on the outside of the distributing disk. The filling seat is also provided with a driving rack. The driving rack is set on the through hole wall of the filling seat. A driving gear that meshes with the driving rack is provided on the fixed seat. A rotating shaft is fitted in the middle of the driving gear. A transmission gear is fitted at the other end of the rotating shaft. The transmission gear meshes with a connecting gear. The connecting gear is fitted with a connecting shaft. A meshing gear is fitted at the end of the connecting shaft away from the connecting gear. The meshing gear meshes with the external gear ring. The driving rack drives the external gear ring to reciprocate by controlling the rotation of the driving gear through the lifting and lowering of the filling seat.

[0008] Preferably, the bottom of the actuating rod is provided with a material-pushing post.

[0009] Preferably, the side plate is also provided with a support column, the top of the support column is provided with a support ball, the bottom of the external gear ring is provided with an annular groove, and the support ball rests in the annular groove.

[0010] Preferably, the powder feeding device includes a powder hopper and a feeding pipe disposed at the bottom of the powder hopper. An auger feeding rod is installed inside the feeding pipe and the powder hopper, and the auger feeding rod is rotatably disposed inside the feeding pipe and the powder hopper.

[0011] As preferred, the top of the auger discharge rod is provided with a driving rod, the driving rod is sleeved with a stirring pipe, the stirring pipe is sleeved with a stirring rod, the stirring pipe and the driving rod are sleeved through bearings, and the stirring pipe is rotationally arranged in the powder hopper.

[0012] As preferred, the stirring pipe and the driving rod rotate at different speeds.

[0013] Compared with the prior art, the application has the advantages and positive effects that:

[0014] 1. The application provides a glycerophosphoryl choline capsule production automatic feeding system, which is improved on the basis of an existing automatic capsule filling machine in terms of the structure of a powder discharging device and a metering and filling device, so that the purpose of drying and dispersing glycerophosphoryl choline is achieved, the hardening problem caused by the hygroscopic property of glycerophosphoryl choline is avoided, and the filling effect is affected. BRIEF DESCRIPTION OF DRAWINGS

[0015] In order to more clearly illustrate the technical solutions of the embodiments of the application, the drawings needed in the embodiment description will be briefly introduced. Obviously, the drawings in the following description are some embodiments of the application, and other drawings can be obtained by those skilled in the art without creative labor.

[0016] Figure 1 The structure schematic view of the glycerophosphoryl choline capsule production automatic feeding system provided for the embodiment 1 is shown in the figure.

[0017] Figure 2 The front view of the glycerophosphoryl choline capsule production automatic feeding system provided for the embodiment 1 is shown in the figure.

[0018] Figure 3 The front view of the glycerophosphoryl choline capsule production automatic feeding system provided for the embodiment 1 in a partially cutaway state is shown in the figure.

[0019] Figure 4 The structure schematic view of the metering and filling device provided for the embodiment 1 in a partially cutaway state is shown in the figure.

[0020] Figure 5 The top view of the metering barrel provided for the embodiment 1 is shown in the figure.

[0021] Figure 6 The structure schematic view of the driving mechanism of the powder pushing disc provided for the embodiment 1 is shown in the figure.

[0022] In the above figures, 1. Metering barrel; 11. Metering hole; 12. Material guide cover; 121. Top plate; 1211. Rotating tube; 122. Side plate; 123. Aeration column; 13. Aeration chamber; 14. Support column; 15. Support ball; 2. Filling seat; 21. Filling rod; 22. Drive rack; 3. Fixed seat; 31. Lifting cylinder; 32. Drive gear; 33. Drive seat; 34. Rotating shaft; 35. Transmission gear; 36. Connecting gear; 37. Connecting shaft; 38. Meshing gear; 4. Powder actuating disc; 41. Rotating shaft; 42. Distributing disc; 43. Actuating rod; 44. External gear ring; 45. Actuating column; 5. Powder hopper; 51. Feeding pipe; 6. Screw conveyor feeding rod; 61. Drive rod; 62. Screw conveyor drive motor; 7. Stirring pipe; 71. Stirring rod; 72. Stirring drive motor; 8. Hollow rotating platform; 9. Rotary joint. Detailed Implementation

[0023] To better understand the above-mentioned objectives, features, and advantages of the present invention, the present invention will be further described below in conjunction with the accompanying drawings and embodiments. It should be noted that, unless otherwise specified, the embodiments and features described in these embodiments can be combined with each other.

[0024] Numerous specific details are set forth in the following description in order to provide a full understanding of the invention. However, the invention may also be practiced in other ways than those described herein, and therefore the invention is not limited to the specific embodiments disclosed in the following specification.

[0025] Example 1, such as Figures 1-6 As shown, this embodiment aims to improve the existing automatic capsule filling machine to meet the needs of glycerophosphorylcholine capsule filling. To this end, the automatic feeding system for glycerophosphorylcholine capsule production provided in this embodiment includes a powder feeding device and a metering and filling device located below the powder feeding device. The metering and filling device includes a rotatable metering barrel 1 and a filling seat 2 located above the metering barrel 1. A filling rod 21 is provided on the filling seat 2. A metering hole 11 that cooperates with the filling rod 21 is provided at the bottom of the metering barrel 1. A fixed seat 3 is also provided between the filling seat 2 and the metering barrel 1. The filling seat 2 is raised and lowered above the fixed seat 3. A through hole for feeding is provided in the middle of both the filling seat 2 and the fixed seat 3.

[0026] As the prior art, the filling seat 2 is arranged above the fixed seat 3 by the lifting cylinder 31, and the fixed seat 3 and the fixed end of the lifting cylinder 31 are fixed by bolts. Since the present embodiment is directed to the automatic filling machine for the stuffed capsule, it is mainly to press the separated powder in the measuring barrel 1 into the measuring hole 11 by different filling rods 21, and finally complete the filling of the capsule. Therefore, the measuring barrel 1 needs to rotate, and the rotating measuring hole 11 is below the different filling rods 21, and the filling rod 21 needs to be lifted to complete the pressing of the powder into the measuring hole 11. The above structure is the common structure of the measuring and filling device in the prior art automatic filling machine for the stuffed capsule, and therefore, in the present embodiment, no detailed description is given.

[0027] Considering that the use environment of the automatic filling machine for the stuffed capsule cannot avoid humidity, it is necessary to dehumidify the glycerophosphoryl choline. Therefore, in the present embodiment, a material guiding cover 12 is arranged at the bottom of the measuring barrel 1, and the material guiding cover 12 includes a top plate 121 and a side plate 122 arranged at the edge of the top plate 121. In the present embodiment, the pressing stage of the filling rod 21 is divided into six stages, and therefore, the top plate 121 is hexagonally arranged, and the side plate 122 is trapezoidally arranged. Each side plate 122 corresponds to a group of filling rods 21.

[0028] In order to make the glycerophosphoryl choline flow into the measuring hole 11 effectively, the side plate 122 is arranged to be inclined downward, and at the same time, the material guiding cover 12 forms an aeration cavity 13 with the bottom of the measuring barrel 1 under the action of the side plate 122. In the present embodiment, in order to facilitate installation, a hole is opened in the bottom of the measuring barrel 1, and at the same time, a sealing disc is used and fixed by bolts. A hollow rotating platform 8 is arranged at the bottom of the measuring barrel 1, and the purpose of arranging the hollow rotating platform 8 is mainly to expose the center of the measuring barrel 1 to facilitate aeration. The measuring barrel 1 is arranged to rotate through the hollow rotating platform 8, and at the same time, a rotary joint 9 is arranged at the bottom of the measuring barrel 1. The air outlet end of the rotary joint 9 extends into the aeration cavity 13. An aeration column 123 is arranged on the side plate 122, and the aeration columns 123 are uniformly distributed on the side plate 122 of the material guiding cover 12. The aeration columns 123 are provided with aeration holes. In this way, the aeration has two effects, one is to break up the glycerophosphoryl choline powder which is bonded together, and the other purpose is to reduce the humidity in the measuring barrel 1 by blowing hot air of a certain temperature, so as to achieve the purpose of dehumidification.

[0029] In view of the fact that the air pressure of the aeration cannot be too high, some of the cohesive powder may not be able to be scattered by the air, therefore, a powder stirring disc 4 is further arranged on the top of the guide cover 12, the powder stirring disc 4 comprises a rotating shaft 41 sleeved on the top of the guide cover 12 and a distributing disc 42 arranged on the top of the rotating shaft 41, in view of the fact that the powder in the metering barrel 1 has a certain thickness and the metering barrel 1 is in a rotating state, therefore, a driving mechanism of the powder stirring disc 4 is needed, in order to avoid the interference between the driving mechanism of the powder stirring disc 4 and the rotation of the metering barrel 1, therefore, in the embodiment, a rotating tube 1211 is arranged on the top of the top plate 121, the rotating shaft 41 is sleeved in the rotating tube 1211 through a bearing, in this way, the rotation of the metering barrel 1 will not interfere with the fixed powder stirring disc 4.

[0030] In order to achieve the purpose of stirring the glycerophosphoryl choline in the metering barrel 1, in the embodiment, a stirring rod 43 is arranged on the side wall of the distributing disc 42, in the embodiment, six stirring rods 43 are evenly arranged on the side wall of the distributing disc 42, an external gear ring 44 is arranged on the end of the stirring rod 43 away from the distributing disc 42, and the external gear ring 44 is sleeved on the outside of the distributing disc 42.

[0031] In view of the fact that the filling seat 2 needs to be lifted and lowered, the lifting and lowering will generate power, therefore, in order to reduce the cost of the improvement as much as possible, in the embodiment, a driving rack 22 is further arranged on the filling seat 2, the driving rack 22 is arranged on the wall of the through hole of the filling seat 2, in view of the fact that the fixing seat 3 is in a static state and the metering barrel 1 is in a rotating state, therefore, the driving mechanism needs to be arranged on the fixing seat 3, therefore, a driving gear 32 engaged with the driving rack 22 is arranged on the fixing seat 3, at the same time, a driving seat 33 is arranged on the fixing seat 3, the driving seat 33 is in a U shape and is mainly used for installing a bearing, a rotating shaft 34 is sleeved in the middle of the driving gear 32, the two ends of the rotating shaft 34 pass through the bearings, at the same time, a transmission gear 35 is sleeved on the other end of the rotating shaft 34, the transmission gear 35 is a bevel gear, the transmission gear 35 is engaged with a connecting gear 36, the connecting gear 36 is also a bevel gear, the connecting gear 36 is sleeved with a connecting shaft 37, the connecting shaft 37 is externally sleeved with a bearing, the bearing is sleeved on the fixing seat 3, an engaging gear 38 is sleeved on the end of the connecting shaft 37 away from the connecting gear 36, the engaging gear 38 is engaged with the external gear ring 44, in order to ensure the stability of the engaging gear 38, a stabilizing tube can be arranged on the bottom of the fixing seat 3, the connecting shaft 37 passes through the stabilizing tube, at the same time, a bearing is further arranged in the stabilizing tube, so as to ensure the stability of the rotation of the connecting shaft 37.

[0032] In this way, the filling seat 2 drives the driving rack 22 to lift during lifting, the driving rack 22 drives the driving gear 32 to rotate, thereby driving the transmission gear 35 to rotate, and the rotation of the transmission gear 35 drives the connecting gear 36 and the meshing gear 38 to rotate, and the rotation of the meshing gear 38 drives the outer gear 44 to rotate, thereby realizing the reciprocating swing of the powder stirring disc 4. In order to ensure the stirring effect of glycerophosphoryl choline, a stirring column 45 is arranged at the bottom of the stirring rod 43. The stirring column 45 is arranged on the stirring rod 43 in a spaced manner, and is arranged in the gap between the aeration columns 123, so that it can cooperate with the aeration columns 123 to double the crushing effect.

[0033] In order to ensure the stability of the powder stirring disc 4, in the embodiment, a supporting column 14 is further arranged on the side plate 122, a supporting ball 15 is arranged at the top of the supporting column 14, and an annular groove is arranged at the bottom of the outer gear 44, and the supporting ball 15 is arranged in the annular groove. In this way, the stability of the powder stirring disc 4 is ensured, and the rotation of the two is not affected.

[0034] Most of the glycerophosphoryl choline is in the powder feeding device, and in order to ensure the crushing effect at the source, in the embodiment, the powder feeding device comprises a powder hopper 5 and a feeding pipe 51 arranged at the bottom of the powder hopper 5, and a screw feeding rod 6 is sleeved in the feeding pipe 51 and the powder hopper 5. Meanwhile, a driving rod 61 is arranged at the top of the screw feeding rod 6, a stirring pipe 7 is sleeved outside the driving rod 61, a stirring rod 71 is sleeved outside the stirring pipe 7, the stirring pipe 7 and the driving rod 61 are sleeved through bearings, and the stirring pipe 7 is rotatably arranged in the powder hopper 5. In the embodiment, the screw feeding rod 6 realizes different rotating speeds between the stirring pipe 7 and the driving rod 61 through different motors. The crushing effect is further improved, and the screw feeding rod 6 also has the purpose of controlling the feeding amount, thereby ensuring the stability of the whole system.

[0035] Through the above arrangement, the problem of moisture absorption of glycerophosphoryl choline during filling is effectively solved, and the normal operation of the filling type capsule automatic filling machine is ensured.

[0036] The above is only a preferred embodiment of the present application, and is not intended to limit the present application in other forms. Any skilled person in the art can modify or change the above disclosed technical content to equivalent embodiments applied to other fields, but any simple modification, equivalent change and modification made on the basis of the technical essence of the present application to the above embodiments still belongs to the protection scope of the technical scheme of the present application.

Claims

1. An automatic feeding system for producing a glycerylphosphorylcholine capsule, comprising a powder discharging device and a metering and filling device arranged below the powder discharging device, wherein, The metering filling device comprises a rotationally arranged metering barrel and a filling seat arranged above the metering barrel, the filling seat is provided with a filling rod, the bottom of the metering barrel is provided with a metering hole matched with the filling rod, a fixing seat is further arranged between the filling seat and the metering barrel, the filling seat is arranged above the fixing seat in a lifting manner, the middle part of the filling seat and the fixing seat is provided with a through hole for discharging, characterized in that the bottom of the metering barrel is provided with a material guiding cover, the material guiding cover comprises a top plate and a side plate arranged at the edge of the top plate, the side plate is arranged in an inclined downward manner, the material guiding cover forms an aeration cavity between the bottom of the metering barrel under the action of the side plate, the bottom of the metering barrel is provided with a hollow rotating platform, the metering barrel is rotationally arranged through the hollow rotating platform, the bottom of the metering barrel is further provided with a rotating joint, the air outlet end of the rotating joint extends into the aeration cavity, the side plate is provided with an aeration column, the aeration columns are uniformly distributed on the side plate of the material guiding cover, and the aeration column is provided with an aeration hole.

2. The automatic feeding system for the production of glycerylphosphorylcholine capsules according to claim 1, characterized in that, The top of the material guiding cover is further provided with a powder stirring disc, the powder stirring disc comprises a rotating shaft sleeved on the top of the material guiding cover and a distribution disc arranged at the top of the rotating shaft, the side wall of the distribution disc is provided with a stirring rod, the stirring rods are uniformly distributed on the side wall of the distribution disc, the end of the stirring rod away from the distribution disc is provided with an external gear ring, the external gear ring is sleeved on the outside of the distribution disc, the filling seat is further provided with a driving rack, the driving rack is arranged on the wall of the through hole of the filling seat, the fixing seat is provided with a driving gear engaged with the driving rack, the middle part of the driving gear is sleeved with a rotating shaft, the other end of the rotating shaft is sleeved with a transmission gear, the transmission gear is engaged with a connecting gear, the connecting gear is sleeved with a connecting shaft, the end of the connecting shaft away from the connecting gear is sleeved with an engaging gear, the engaging gear is arranged in engagement with the external gear ring, and the driving rack controls the rotation of the driving gear through the lifting of the filling seat, so as to drive the external gear ring to reciprocating rotate.

3. The automatic feeding system for the production of glycerylphosphorylcholine capsules according to claim 2, characterized in that, The bottom of the stirring rod is provided with a stirring column.

4. The automatic feeding system for the production of glycerylphosphorylcholine capsules according to claim 3, characterized in that, The side plate is further provided with a supporting column, the top of the supporting column is provided with a supporting ball, the bottom of the external gear ring is provided with an annular groove, and the supporting ball is supported in the annular groove.

5. The automatic feeding system for the production of glycerylphosphorylcholine capsules according to any one of claims 1 to 4, characterized in that, The powder discharging device comprises a powder hopper and a discharging pipe arranged at the bottom of the powder hopper, a screw discharging rod is sleeved in the discharging pipe and the powder hopper, and the screw discharging rod is rotationally arranged in the discharging pipe and the powder hopper.

6. The automatic feeding system for the production of glycerylphosphorylcholine capsules according to claim 5, characterized in that, The top of the screw discharging rod is provided with a driving rod, the driving rod is externally sleeved with a stirring pipe, the stirring pipe is externally sleeved with a stirring rod, the stirring pipe and the driving rod are sleeved through bearings, and the stirring pipe is rotationally arranged in the powder hopper.

7. The automatic feeding system for the production of glycerylphosphorylcholine capsules according to claim 6, characterized in that, The stirring pipe and the driving rod rotate at different speeds.

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