Collagen tripeptide compound for after-sun repair and preparation method thereof

Abstract

The invention provides a collagen tripeptide compound for after-sun repair and a preparation method thereof, and belongs to the technical field of after-sun repair compounds. The collagen tripeptide compound for after-sun repair is prepared from the following raw materials in parts by weight: 10 to 20 parts of collagen tripeptide, 1 to 5 parts of sodium hyaluronate, 3 to 8 parts of modified glycerol, 1 to 3 parts of herba centellae extract, 1 to 3 parts of green tea extract, 0.5 to 2 parts of disodium glycyrrhizinate, 1 to 3 parts of seaweed extract, 2 to 5 parts of squalane, 0.5 to 2 parts of vitamin E, 2 to 5 parts of vitamin B5, 1 to 3 parts of allantoin, 0.5 to 2 parts of lavender extract, 1 to 3 parts of modified titanium dioxide and 0.5 to 1.5 parts of thickening agent. 0.3-1 part of a preservative, 1-3 parts of an emulsifier and 8-12 parts of deionized water. According to the collagen tripeptide compound for after-sun repair and the preparation method of the collagen tripeptide compound, various problems of after-sun skin can be remarkably improved.

Description

Technical Field

[0001] The invention relates to the technical field of after-sun repairing complexes, and in particular to a collagen tripeptide complex for after-sun repairing and a preparation method thereof. Background Art

[0002] Sunburn is an unavoidable problem in outdoor activities, especially in seasons or environments with strong ultraviolet radiation. The skin is easily damaged, and symptoms such as redness, swelling, pain, dryness, and peeling appear. These sunburns not only affect the appearance, but may also have long-term effects on skin health, such as accelerating skin aging and increasing the risk of skin cancer.

[0003] Traditional after-sun repair products mostly rely on chemically synthesized ingredients. Although they can relieve the discomfort caused by sunburn to a certain extent, long-term use may cause skin irritation, allergies and other problems, and some chemical ingredients may pose a potential threat to human health. Therefore, as consumers' requirements for the safety and naturalness of skin care products are increasing, it is particularly important to develop safer and more effective after-sun repair products.

[0004] In recent years, with the rapid development of biotechnology, more and more natural ingredients have been used in skin care products. These natural ingredients not only have excellent moisturizing, repairing and antioxidant properties, but also reduce the risk of irritation and allergies caused by chemical synthetic ingredients. For example, certain plant extracts, marine biological extracts, vitamins and minerals have been proven to have a positive care effect on the skin.

[0005] In the field of after-sun repair, researchers are also constantly exploring more effective natural ingredients and compound solutions. Through in-depth research on the mechanism and repair process of skin sunburn, some potential natural ingredients have been discovered, such as collagen and its degradation products (such as collagen tripeptide, etc.). These ingredients can penetrate deep into the bottom layer of the skin, provide the necessary nutrients for damaged cells, and promote the regeneration and repair of skin cells.

[0006] In addition, in order to further improve the performance of after-sun repair products, researchers are constantly exploring and optimizing the preparation process of raw materials. By improving extraction, purification and modification techniques, the stability and biological activity of natural ingredients can be significantly improved, thereby enhancing the moisturizing, repairing and sun protection effects of the products.

[0007] In summary, with the increasing demand of consumers for the safety and naturalness of skin care products and the rapid development of biotechnology, the development of after-sun repair products is moving towards a safer, more efficient and natural direction. Through in-depth research on natural ingredients and preparation processes, after-sun repair products with excellent performance can be developed to provide consumers with more comprehensive and efficient after-sun care solutions. Summary of the invention

[0008] The purpose of the present invention is to provide a collagen tripeptide complex for after-sun repair and a preparation method thereof, which can significantly improve various problems of after-sun skin.

[0009] To achieve the above object, the present invention provides a collagen tripeptide complex for after-sun repair, which is composed of the following raw materials in parts by weight: 10-20 parts of collagen tripeptide, 1-5 parts of sodium hyaluronate, 3-8 parts of modified glycerin, 1-3 parts of Centella asiatica extract, 1-3 parts of green tea extract, 0.5-2 parts of disodium glycyrrhizinate, 1-3 parts of seaweed extract, 2-5 parts of squalane, 0.5-2 parts of vitamin E, 2-5 parts of vitamin B5, 1-3 parts of urea capsules, 0.5-2 parts of lavender extract, 1-3 parts of modified titanium dioxide, 0.5-1.5 parts of thickener, 0.3-1 parts of preservative, 1-3 parts of emulsifier, and 8-12 parts of deionized water; Wherein, the preparation method of modified glycerol is as follows: A1. Pour glycerol into the reactor, heat to 60°C and stir; B1. Under stirring conditions, add the titanate coupling agent to glycerol in two drops according to a predetermined ratio, 40% for the first drop and 60% for the second drop. After each drop, keep stirring for 10 minutes; C1. After the titanate coupling agent is added dropwise, continue stirring for 10 minutes, then add the aluminosilicate coupling agent dropwise to the glycerol in two portions according to a predetermined ratio, 40% for the first drop and 60% for the second drop, and keep stirring for 10 minutes after each dropwise addition; D1. After the titanate coupling agent and the aluminosilicate coupling agent are added dropwise, the reaction temperature is maintained at 85°C, the stirring speed is adjusted to 2000r / min, and the stirring is continued for 60 minutes; E1. After the reaction is completed, the mixture is cooled to 25°C and filtered through filter paper to ensure the purity of the modified glycerol; The preparation method of modified titanium dioxide is as follows: A2. In a 250 ml beaker, mix 50 ml of isopropyl titanate, 25 ml of ethylene glycol, and 25 ml of ethanol. Stir with a magnetic stirrer at room temperature until a uniform and transparent solution A is formed. B2. Take another 250ml beaker, add 100ml of deionized water, and while stirring, add 5ml of nitric acid dropwise to adjust the pH value to 4; C2. Add solution A dropwise to the nitric acid aqueous solution at a rate of 3 drops per second while continuing to stir; D2, the temperature of the hydrolysis and polycondensation reactions were both controlled at 45°C, and the mixture was heated in a water bath and stirred for 4 hours to form a sol, and the obtained sol was aged at room temperature for 24 hours to obtain an aged sol; E2, placing the aged sol in a freeze dryer for freeze drying; F2, grinding the dried gel into powder, placing the powder into a muffle furnace, and calcining it under a nitrogen atmosphere to obtain calcined titanium dioxide powder; G2, adding the calcined titanium dioxide powder to the EDTA solution, stirring the reaction at 65°C for 3 hours using a magnetic stirrer; H2. After the reaction is completed, the product is centrifuged and washed, and the washed product is placed in an oven and dried at 80°C for 12 hours, and the dried product is ground into fine powder.

[0010] Modified titanium dioxide: The modified titanium dioxide prepared by the above method has more excellent physical sunscreen performance. Its micronization technology enables titanium dioxide powder to be better dispersed in the product to form a uniform sunscreen layer, effectively blocking the invasion of ultraviolet rays, thereby significantly enhancing the sunscreen effect of the product and providing comprehensive ultraviolet protection for the skin.

[0011] Compared with traditional titanium dioxide, modified titanium dioxide has better skin compatibility and low irritation, which means it can reduce skin irritation and allergic reactions, improve product safety and comfort, and is suitable for people with all skin types.

[0012] The modified titanium dioxide has higher chemical stability and light stability, and can maintain its sun protection performance under various light and temperature conditions, extending the shelf life and use effect of the product.

[0013] Modified glycerin: By introducing a specific coupling agent to modify glycerin, the moisturizing properties of glycerin can be significantly improved. Modified glycerin can lock in skin moisture more effectively and form a lasting moisturizing barrier, thereby alleviating the dryness and tightness of the skin after sun exposure and keeping the skin hydrated and smooth.

[0014] Modified glycerin can also enhance the skin's barrier function, reduce the loss of skin moisture, and help repair damaged skin barriers. This is especially important for sunburned skin, as sunburn often destroys the skin's barrier structure, leading to moisture loss and easier penetration of external irritants.

[0015] Modified glycerin has good stability and compatibility, and can be well mixed with other skin care ingredients to improve the overall stability and quality of the product. In addition, it can also enhance the consistency and smoothness of the product and improve the use experience.

[0016] There is an indirect synergistic effect between modified glycerol and modified titanium dioxide: Enhanced protection and repair dual effects: Modified titanium dioxide, as a physical sunscreen, can form a uniform and dense sunscreen layer on the skin surface, effectively blocking the damage of ultraviolet rays and reducing the risk of sunburn. Modified glycerin penetrates deep into the skin, providing a lasting moisturizing effect, while enhancing the skin barrier function and helping to repair the skin barrier damaged by ultraviolet rays. The combination of the two not only provides external sun protection, but also strengthens internal moisturizing and repair, forming a dual effect of protection and repair, providing more comprehensive protection for the skin.

[0017] Improve the overall stability and comfort of the product: The micronization technology and high stability of modified titanium dioxide enable the product to maintain a long-term sun protection effect and is not easily invalidated by light or temperature changes. The compatibility and stability of modified glycerin enable it to be well mixed with other skin care ingredients to improve the overall stability of the product. The two work together to make after-sun repair products more stable and easy to store, and provide better comfort and user experience during use.

[0018] Promotes skin health and recovery: The sunscreen effect of modified titanium dioxide helps reduce UV damage to the skin and reduces the risk of skin aging and cancer. The moisturizing and barrier repair functions of modified glycerin help promote the regeneration and repair of skin cells and accelerate the skin's recovery process. The combination of the two not only helps relieve sunburn symptoms, but also promotes long-term skin health and rejuvenation.

[0019] Preferably, it is composed of the following raw materials in parts by weight: 10 parts of collagen tripeptide, 1 part of sodium hyaluronate, 3 parts of modified glycerin, 1 part of Centella asiatica extract, 1 part of green tea extract, 0.5 parts of disodium glycyrrhizinate, 1 part of seaweed extract, 2 parts of squalane, 0.5 parts of vitamin E, 2 parts of vitamin B5, 1 part of urea capsule, 0.5 parts of lavender extract, 1 part of modified titanium dioxide, 0.5 parts of thickener, 0.3 parts of preservative, 1 part of emulsifier, and 8 parts of deionized water.

[0020] Preferably, it is composed of the following raw materials in parts by weight: 20 parts of collagen tripeptide, 5 parts of sodium hyaluronate, 8 parts of modified glycerin, 3 parts of Centella asiatica extract, 3 parts of green tea extract, 2 parts of disodium glycyrrhizinate, 3 parts of seaweed extract, 5 parts of squalane, 2 parts of vitamin E, 5 parts of vitamin B5, 3 parts of urea capsules, 2 parts of lavender extract, 3 parts of modified titanium dioxide, 1.5 parts of thickener, 1 part of preservative, 3 parts of emulsifier, and 12 parts of deionized water.

[0021] Preferably, it is composed of the following raw materials in parts by weight: 15 parts of collagen tripeptide, 3 parts of sodium hyaluronate, 5 parts of modified glycerin, 2 parts of Centella asiatica extract, 2 parts of green tea extract, 1 part of disodium glycyrrhizinate, 2 parts of seaweed extract, 3 parts of squalane, 1 part of vitamin E, 3 parts of vitamin B5, 2 parts of urea capsules, 1 part of lavender extract, 2 parts of modified titanium dioxide, 1 part of thickener, 0.5 parts of preservatives, 2 parts of emulsifiers, and 10 parts of deionized water.

[0022] Preferably, in steps A1-C1, the stirring rate is 300 r / min; in step B1, the predetermined ratio is 5% of the weight of glycerol; in step C1, the predetermined ratio is 4% of the weight of glycerol; in step E1, the pore size of the filter paper is 0.4-10 μm.

[0023] Preferably, in step A2, the stirring rate is 800 r / min; in step B2, the stirring rate is 300 r / min; in step C2, the stirring rate is 300 r / min; in step D2, the stirring rate is 400 r / min; in step E2, the freeze-drying temperature is controlled at -50°C, the vacuum degree is 10 Pa, and the drying time is 48 hours; in step F2, the calcination temperature is controlled at 500°C, and the calcination time is 3.5 hours; in step G2, the stirring rate is 400 r / min.

[0024] The present invention also provides a method for preparing the above-mentioned collagen tripeptide complex for after-sun repair, comprising the following steps: Step S1, weighing collagen tripeptide, sodium hyaluronate, modified glycerin, Centella asiatica extract, green tea extract, disodium glycyrrhizinate, seaweed extract, squalane, vitamin E, vitamin B5, urea capsule, lavender extract, modified titanium dioxide, thickener, preservative, emulsifier, and deionized water in parts by weight; Step S2, adding deionized water into a reaction kettle, heating to 40-50° C. and stirring, while stirring, adding sodium hyaluronate and collagen tripeptide until they are completely dissolved; Step S3, adding modified glycerin, squalane and vitamin E, stirring after each addition; Step S4, adding Centella asiatica extract, green tea extract, disodium glycyrrhizinate, and seaweed extract in sequence, stirring after each addition; Step S5, adding vitamin B5 and urea capsule, and continuing to stir until completely dissolved; Step S6, using pH test paper or pH meter to adjust the pH value of the solution to 5.5-6.5; Step S7, adding thickener, emulsifier, and preservative, stirring after each addition; Step S8, adding modified titanium dioxide and lavender extract, stirring after each addition; Step S9, transferring the solution in the reaction container to a homogenizer for homogenization, filtering the solution using a microporous filter membrane to remove impurities and particles, and obtaining a collagen tripeptide complex for after-sun repair.

[0025] Preferably, in step S2, the stirring rate is 100-200 r / min; in step S3, the stirring rate is 100-150 r / min; in step S4, the stirring rate is 80-120 r / min; in step S5, the stirring rate is 100-110 r / min; in step S7, the stirring rate is 150-200 r / min; in step S8, the stirring rate is 100-120 r / min.

[0026] Preferably, in step S2, the stirring time is 10 to 20 minutes; in step S3, the stirring time is 5 to 10 minutes; in step S4, the stirring time is 5 to 8 minutes; in step S5, the stirring time is 5 to 10 minutes; in step S7, the stirring time is 10 to 15 minutes; in step S8, the stirring time is 5 to 8 minutes.

[0027] Preferably, in step S9, the pore size of the microporous filter membrane is 0.45 μm.

[0028] Therefore, the present invention adopts the above-mentioned collagen tripeptide complex for after-sun repair and its preparation method, and the beneficial technical effects are as follows: The present invention not only utilizes the powerful moisturizing and repairing ability of collagen tripeptide and sodium hyaluronate, but also combines the excellent moisturizing barrier brought by modified glycerin, as well as the anti-inflammatory and antioxidant properties of various plant extracts such as Centella asiatica extract, green tea extract, and disodium glycyrrhizinate, effectively alleviating skin discomfort after sun exposure and accelerating the skin's self-repair process.

[0029] In addition, the addition of seaweed extract and squalane further enhances the skin's barrier function and improves the moisturizing effect, while vitamin E and vitamin B5 work synergistically to provide the skin with necessary nutrients and promote cell regeneration. The addition of urea capsules helps soften keratin and promotes the absorption of subsequent skin care products, while lavender extract brings a soothing and relaxing effect, reducing skin tension.

[0030] As a physical sunscreen, modified titanium dioxide not only enhances the sunscreen performance of the product, but also effectively blocks the secondary damage of ultraviolet rays to the skin. In terms of the preparation method, the present invention ensures the full dissolution and uniform dispersion of the raw materials by precisely controlling the reaction conditions and stirring rate of each step, and finally obtains a collagen tripeptide complex for after-sun repair with fine texture, strong stability and easy absorption. DETAILED DESCRIPTION

[0031] The technical solution of the present invention is further illustrated by the following examples.

[0032] Unless otherwise defined, technical or scientific terms used in the present invention shall have the common meanings understood by one having ordinary skills in the field to which the present invention belongs.

[0033] Preparation of modified glycerol and modified titanium dioxide.

[0034] The preparation method of modified glycerol is as follows: A1. Pour glycerol into the reactor, heat to 60°C and stir (stirring rate is 300r / min); B1. Under stirring conditions, add titanate coupling agent to glycerol in two drops according to a predetermined ratio (5% of the weight of glycerol), 40% for the first drop and 60% for the second drop. After each drop, keep stirring for 10 minutes (stirring rate is 300r / min); C1. After the titanate coupling agent is added dropwise, continue stirring for 10 minutes, then add the aluminosilicate coupling agent dropwise to the glycerol in two portions according to the predetermined ratio, 40% for the first drop and 60% for the second drop, and keep stirring for 10 minutes after each drop (stirring rate is 300r / min); D1. After the titanate coupling agent and the aluminosilicate coupling agent are added dropwise, the reaction temperature is maintained at 85°C, the stirring speed is adjusted to 2000r / min, and the stirring is continued for 60 minutes; E1. After the reaction is completed, the mixture is cooled to 25°C and filtered through filter paper to ensure the purity of the modified glycerol; The preparation method of modified titanium dioxide is as follows: A2. In a 250 ml beaker, mix 50 ml of isopropyl titanate, 25 ml of ethylene glycol, and 25 ml of ethanol. Stir with a magnetic stirrer (stirring rate of 800 r / min) at room temperature until a uniform and transparent solution A is formed. B2. Take another 250ml beaker, add 100ml deionized water, and while stirring (stirring rate is 300r / min), add 5ml nitric acid dropwise to adjust the pH value to 4; C2. Add solution A dropwise into the nitric acid aqueous solution at a rate of 3 drops per second while continuing to stir (stirring rate is 300 r / min); D2. The temperature of the hydrolysis and polycondensation reactions were both controlled at 45°C, and the mixture was heated in a water bath and stirred for 4 hours (stirring rate was 400 r / min) to form a sol. The obtained sol was aged at room temperature for 24 hours to obtain an aged sol. E2, placing the aged sol in a freeze dryer for freeze drying; F2, grinding the dried gel into powder, placing the powder into a muffle furnace, and calcining it under a nitrogen atmosphere to obtain calcined titanium dioxide powder (calcination temperature is 500° C., calcination time is 3.5 hours); G2, add the calcined titanium dioxide powder into the EDTA solution, and stir the reaction at 65 °C for 3 hours using a magnetic stirrer (stirring rate is 400 r / min); H2. After the reaction is completed, the product is centrifuged and washed, and the washed product is placed in an oven and dried at 80°C for 12 hours, and the dried product is ground into fine powder.

[0035] The modified glycerol and modified titanium dioxide of Example 1, Example 2 and Example 3 were all prepared according to the above method.

[0036] Embodiment 1 Step S1, weigh by weight: 15 parts of collagen tripeptide, 3 parts of sodium hyaluronate, 5 parts of modified glycerin, 2 parts of Centella asiatica extract, 2 parts of green tea extract, 1 part of disodium glycyrrhizinate, 2 parts of seaweed extract, 3 parts of squalane, 1 part of vitamin E, 3 parts of vitamin B5, 2 parts of urea capsules, 1 part of lavender extract, 2 parts of modified titanium dioxide, 1 part of thickener, 0.5 parts of preservative, 2 parts of emulsifier, and 10 parts of deionized water.

[0037] Step S2, adding deionized water into the reaction kettle, heating to 50°C and stirring (stirring rate 100 r / min, time 10 minutes), while stirring, adding sodium hyaluronate and collagen tripeptide until completely dissolved; Step S3, adding modified glycerol, squalane and vitamin E, stirring after each addition (stirring rate is 100 r / min, time is 5 minutes); Step S4, adding Centella asiatica extract, green tea extract, disodium glycyrrhizinate, and seaweed extract in sequence, stirring after each addition (stirring rate is 80 r / min, time is 5 minutes); Step S5, adding vitamin B5 and urea capsule, and continuing to stir until completely dissolved (stirring rate is 100 r / min, time is 5 minutes); Step S6, using pH test paper or a pH meter to adjust the pH value of the solution to 5.5; Step S7, adding thickener, emulsifier, and preservative, stirring after each addition; (stirring rate is 150 r / min, time is 10 minutes) Step S8, adding modified titanium dioxide and lavender extract, stirring after each addition (stirring rate is 100 r / min, time is 5 minutes); Step S9, transferring the solution in the reaction container to a homogenizer for homogenization, filtering the solution using a microporous filter membrane to remove impurities and particles, and obtaining a collagen tripeptide complex for after-sun repair.

[0038] Embodiment 2 Step S1, weigh by weight: 10 parts of collagen tripeptide, 1 part of sodium hyaluronate, 3 parts of modified glycerin, 1 part of Centella asiatica extract, 1 part of green tea extract, 0.5 parts of disodium glycyrrhizinate, 1 part of seaweed extract, 2 parts of squalane, 0.5 parts of vitamin E, 2 parts of vitamin B5, 1 part of urea capsule, 0.5 parts of lavender extract, 1 part of modified titanium dioxide, 0.5 parts of thickener, 0.3 parts of preservative, 1 part of emulsifier, and 8 parts of deionized water.

[0039] Step S2, adding deionized water into the reaction kettle, heating to 50°C and stirring (stirring rate 200 r / min, time 20 minutes), while stirring, adding sodium hyaluronate and collagen tripeptide until completely dissolved; Step S3, adding modified glycerol, squalane and vitamin E, stirring after each addition (stirring rate is 150 r / min, time is 10 minutes); Step S4, adding Centella asiatica extract, green tea extract, disodium glycyrrhizinate, and seaweed extract in sequence, stirring after each addition (stirring rate is 120 r / min, time is 8 minutes); Step S5, adding vitamin B5 and urea capsule, and continuing to stir until completely dissolved (stirring rate is 110 r / min, time is 10 minutes); Step S6, adjusting the pH value of the solution to 6.5; Step S7, adding thickener, emulsifier, and preservative, stirring after each addition; (stirring rate is 200 r / min, time is 15 minutes) Step S8, adding modified titanium dioxide and lavender extract, stirring after each addition (stirring rate is 120 r / min, time is 8 minutes); Step S9, transferring the solution in the reaction container to a homogenizer for homogenization, filtering the solution using a microporous filter membrane to remove impurities and particles, and obtaining a collagen tripeptide complex for after-sun repair.

[0040] Embodiment 3 Step S1, weigh by weight: 20 parts of collagen tripeptide, 5 parts of sodium hyaluronate, 8 parts of modified glycerin, 3 parts of Centella asiatica extract, 3 parts of green tea extract, 2 parts of disodium glycyrrhizinate, 3 parts of seaweed extract, 5 parts of squalane, 2 parts of vitamin E, 5 parts of vitamin B5, 3 parts of urea capsules, 2 parts of lavender extract, 3 parts of modified titanium dioxide, 1.5 parts of thickener, 1 part of preservative, 3 parts of emulsifier, and 12 parts of deionized water.

[0041] Step S2, adding deionized water into the reaction kettle, heating to 50°C and stirring (stirring rate 200 r / min, time 20 minutes), while stirring, adding sodium hyaluronate and collagen tripeptide until completely dissolved; Step S3, adding modified glycerol, squalane and vitamin E, stirring after each addition (stirring rate is 150 r / min, time is 10 minutes); Step S4, adding Centella asiatica extract, green tea extract, disodium glycyrrhizinate, and seaweed extract in sequence, stirring after each addition (stirring rate is 120 r / min, time is 8 minutes); Step S5, adding vitamin B5 and urea capsule, and continuing to stir until completely dissolved (stirring rate is 110 r / min, time is 10 minutes); Step S6, using pH test paper or a pH meter to adjust the pH value of the solution to 6.0; Step S7, adding thickener, emulsifier, and preservative, stirring after each addition; (stirring rate is 200 r / min, time is 15 minutes) Step S8, adding modified titanium dioxide and lavender extract, stirring after each addition (stirring rate is 120 r / min, time is 8 minutes); Step S9, transferring the solution in the reaction container to a homogenizer for homogenization, filtering the solution using a microporous filter membrane to remove impurities and particles, and obtaining a collagen tripeptide complex for after-sun repair.

[0042] Comparative Example 1 The difference between this comparative example and Example 1 is that the modified glycerin is removed. Compared with Example 1, the collagen tripeptide complex for after-sun repair prepared in this comparative example has a weaker performance in terms of moisturizing barrier. Volunteer tests show that although this product can alleviate some symptoms of after-sun skin, the moisturizing effect of the skin is not as good as that of Example 1, and the dryness is more obvious, and the recovery speed is slower.

[0043] Comparative Example 2 The difference between this comparative example and Example 1 is that the modified titanium dioxide is removed. Compared with Example 1, the collagen tripeptide complex for after-sun repair prepared in this comparative example performs poorly in terms of sun protection performance. Volunteer tests show that although this product can relieve symptoms such as dryness and redness of the skin after sun exposure, due to the lack of the physical sunscreen effect of modified titanium dioxide, the skin is more susceptible to damage from ultraviolet rays, resulting in uneven skin color and more obvious pigmentation.

[0044] Comparative Example 3 Collagen tripeptide complex for after-sun repair: 8 parts of collagen tripeptide, 6 parts of sodium hyaluronate, 5 parts of modified glycerin, 0.5 parts of Centella asiatica extract, 0.5 parts of green tea extract, 3 parts of disodium glycyrrhizinate, 4 parts of seaweed extract, 2 parts of squalane, 0.1 parts of vitamin E, 1 part of vitamin B5, 4 parts of urea capsules, 3 parts of lavender extract, 1.5 parts of thickener, 0.3 parts of preservative, 3 parts of emulsifier, and 8 parts of deionized water.

[0045] For Examples 1 to 3 and Comparative Examples 1 to 3, scores were made in terms of moisturizing effect, repairing ability, sunscreen performance, anti-inflammatory and antioxidant properties. The scoring method is well known to those skilled in the art and will not be described in detail here.

[0046] Table 1 Scoring results ;

[0047] It is worth noting that the contents not elaborated in detail in the present invention are all prior art and are well known to those skilled in the art.

[0048] Therefore, the present invention adopts the above-mentioned collagen tripeptide complex for after-sun repair and the preparation method thereof, which can significantly improve various problems of after-sun skin.

[0049] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit it. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that they can still modify or replace the technical solution of the present invention with equivalents, and these modifications or equivalent replacements cannot cause the modified technical solution to deviate from the spirit and scope of the technical solution of the present invention.

Claims

1. A collagen tripeptide complex for after-sun repair, characterized in that: The invention is composed of the following raw materials in parts by weight: 10-20 parts of collagen tripeptide, 1-5 parts of sodium hyaluronate, 3-8 parts of modified glycerin, 1-3 parts of Centella asiatica extract, 1-3 parts of green tea extract, 0.5-2 parts of disodium glycyrrhizinate, 1-3 parts of seaweed extract, 2-5 parts of squalane, 0.5-2 parts of vitamin E, 2-5 parts of vitamin B5, 1-3 parts of urea capsules, 0.5-2 parts of lavender extract, 1-3 parts of modified titanium dioxide, 0.5-1.5 parts of thickener, 0.3-1 parts of preservative, 1-3 parts of emulsifier and 8-12 parts of deionized water. Wherein, the preparation method of modified glycerol is as follows: A1. Pour glycerol into the reactor, heat to 60°C and stir; B1. Under stirring conditions, add the titanate coupling agent to glycerol in two drops according to a predetermined ratio, 40% for the first drop and 60% for the second drop. After each drop, keep stirring for 10 minutes; C1. After the titanate coupling agent is added dropwise, continue stirring for 10 minutes, then add the aluminosilicate coupling agent dropwise to the glycerol in two portions according to a predetermined ratio, 40% for the first drop and 60% for the second drop, and keep stirring for 10 minutes after each dropwise addition; D1. After the titanate coupling agent and the aluminosilicate coupling agent are added dropwise, the reaction temperature is maintained at 85°C, the stirring speed is adjusted to 2000r / min, and the stirring is continued for 60 minutes; E1. After the reaction is completed, the mixture is cooled to 25°C and filtered through filter paper to ensure the purity of the modified glycerol; The preparation method of modified titanium dioxide is as follows: A2. In a 250 ml beaker, mix 50 ml of isopropyl titanate, 25 ml of ethylene glycol, and 25 ml of ethanol. Stir with a magnetic stirrer at room temperature until a uniform and transparent solution A is formed. B2. Take another 250ml beaker, add 100ml of deionized water, and while stirring, add 5ml of nitric acid dropwise to adjust the pH value to 4; C2. Add solution A dropwise to the nitric acid aqueous solution at a rate of 3 drops per second while continuing to stir; D2, the temperature of the hydrolysis and polycondensation reactions were both controlled at 45°C, and the mixture was heated in a water bath and stirred for 4 hours to form a sol, and the obtained sol was aged at room temperature for 24 hours to obtain an aged sol; E2, placing the aged sol in a freeze dryer for freeze drying; F2, grinding the dried gel into powder, placing the powder into a muffle furnace, and calcining it under a nitrogen atmosphere to obtain calcined titanium dioxide powder; G2, adding the calcined titanium dioxide powder to the EDTA solution, stirring the reaction at 65°C for 3 hours using a magnetic stirrer; H2. After the reaction is completed, the product is centrifuged and washed, and the washed product is placed in an oven and dried at 80°C for 12 hours, and the dried product is ground into fine powder.

2. The collagen tripeptide complex for after-sun repair according to claim 1, characterized in that: The product is composed of the following raw materials in parts by weight: 10 parts of collagen tripeptide, 1 part of sodium hyaluronate, 3 parts of modified glycerin, 1 part of Centella asiatica extract, 1 part of green tea extract, 0.5 parts of disodium glycyrrhizinate, 1 part of seaweed extract, 2 parts of squalane, 0.5 parts of vitamin E, 2 parts of vitamin B5, 1 part of urea capsule, 0.5 parts of lavender extract, 1 part of modified titanium dioxide, 0.5 parts of thickener, 0.3 parts of preservative, 1 part of emulsifier, and 8 parts of deionized water.

3. The collagen tripeptide complex for after-sun repair according to claim 1, characterized in that: The product is composed of the following raw materials in parts by weight: 20 parts of collagen tripeptide, 5 parts of sodium hyaluronate, 8 parts of modified glycerin, 3 parts of Centella asiatica extract, 3 parts of green tea extract, 2 parts of disodium glycyrrhizinate, 3 parts of seaweed extract, 5 parts of squalane, 2 parts of vitamin E, 5 parts of vitamin B5, 3 parts of urea capsules, 2 parts of lavender extract, 3 parts of modified titanium dioxide, 1.5 parts of thickener, 1 part of preservative, 3 parts of emulsifier, and 12 parts of deionized water.

4. The collagen tripeptide complex for after-sun repair according to claim 1, characterized in that: The product is composed of the following raw materials in parts by weight: 15 parts of collagen tripeptide, 3 parts of sodium hyaluronate, 5 parts of modified glycerin, 2 parts of Centella asiatica extract, 2 parts of green tea extract, 1 part of disodium glycyrrhizinate, 2 parts of seaweed extract, 3 parts of squalane, 1 part of vitamin E, 3 parts of vitamin B5, 2 parts of urea capsules, 1 part of lavender extract, 2 parts of modified titanium dioxide, 1 part of thickener, 0.5 parts of preservative, 2 parts of emulsifier, and 10 parts of deionized water.

5. The collagen tripeptide complex for after-sun repair according to claim 1, characterized in that: In steps A1-C1, the stirring rate is 300 r / min; in step B1, the predetermined ratio is 5% of the weight of glycerol; in step C1, the predetermined ratio is 4% of the weight of glycerol; in step E1, the pore size of the filter paper is 0.4~10 μm.

6. The collagen tripeptide complex for after-sun repair according to claim 1, characterized in that: In step A2, the stirring rate is 800 r / min; in step B2, the stirring rate is 300 r / min; in step C2, the stirring rate is 300 r / min; in step D2, the stirring rate is 400 r / min; in step E2, the freeze-drying temperature is controlled at -50°C, the vacuum degree is 10 Pa, and the drying time is 48 hours; in step F2, the calcination temperature is controlled at 500°C, and the calcination time is 3.5 hours; in step G2, the stirring rate is 400 r / min.

7. A method for preparing the collagen tripeptide complex for after-sun repair according to any one of claims 1 to 6, characterized in that: The following steps are involved: Step S1, weighing collagen tripeptide, sodium hyaluronate, modified glycerin, Centella asiatica extract, green tea extract, disodium glycyrrhizinate, seaweed extract, squalane, vitamin E, vitamin B5, urea capsule, lavender extract, modified titanium dioxide, thickener, preservative, emulsifier, and deionized water in parts by weight; Step S2, adding deionized water into a reaction kettle, heating to 40-50° C. and stirring, while stirring, adding sodium hyaluronate and collagen tripeptide until they are completely dissolved; Step S3, adding modified glycerin, squalane and vitamin E, stirring after each addition; Step S4, adding Centella asiatica extract, green tea extract, disodium glycyrrhizinate, and seaweed extract in sequence, stirring after each addition; Step S5, adding vitamin B5 and urea capsule, and continuing to stir until completely dissolved; Step S6, using pH test paper or pH meter to adjust the pH value of the solution to 5.5-6.5; Step S7, adding thickener, emulsifier, and preservative, stirring after each addition; Step S8, adding modified titanium dioxide and lavender extract, stirring after each addition; Step S9, transferring the solution in the reaction container to a homogenizer for homogenization, filtering the solution using a microporous filter membrane to remove impurities and particles, and obtaining a collagen tripeptide complex for after-sun repair.

8. The method for preparing a collagen tripeptide complex for after-sun repair according to claim 7, characterized in that: In step S2, the stirring rate is 100-200 r / min; in step S3, the stirring rate is 100-150 r / min; in step S4, the stirring rate is 80-120 r / min; in step S5, the stirring rate is 100-110 r / min; in step S7, the stirring rate is 150-200 r / min; in step S8, the stirring rate is 100-120 r / min.

9. The method for preparing a collagen tripeptide complex for after-sun repair according to claim 8, characterized in that: In step S2, the stirring time is 10 to 20 minutes; in step S3, the stirring time is 5 to 10 minutes; in step S4, the stirring time is 5 to 8 minutes; in step S5, the stirring time is 5 to 10 minutes; in step S7, the stirring time is 10 to 15 minutes; in step S8, the stirring time is 5 to 8 minutes.

10. The method for preparing a collagen tripeptide complex for after-sun repair according to claim 9, characterized in that: In step S9, the pore size of the microporous filter membrane is 0.45 μm.