Digestion and metabolism promoting tablet for treating diabetes and preparation method thereof

Abstract

The invention is suitable for the technical field of diabetes treatment, and provides a digestion and metabolism promoting tablet for diabetes treatment and a preparation method thereof. The metformin hydrochloride tablets are prepared from the following components in parts by weight: 45 to 65 parts of metformin hydrochloride, 0.001 to 0.003 part of vitamin D, 3.5 to 6 parts of cortex cinnamomi extract, 7 to 12 parts of fructus lycii extract, 0.5 to 1.6 parts of honey, 3 to 7 parts of starch, 0.4 to 0.6 part of polyvinylpyrrolidone, 0.1 to 0.3 part of magnesium stearate, 6 to 11 parts of filler, 3 to 9 parts of mineral supplement and 2 to 8 parts of dietary fiber. Preferably, the mass ratio of the cortex cinnamomi extract to the fructus lycii extract is 1: 2; the mineral supplement is one or more of magnesium, zinc, calcium and potassium. The preparation method is simple, the synergistic effect of all the components is strong, the traditional Chinese medicine composition is suitable for vast diabetic patients to use, the blood sugar level is effectively controlled, the digestion and metabolism functions of the diabetic patients are remarkably promoted, and the traditional Chinese medicine composition has wide market prospects and clinical application value.

Description

Technical Field

[0001] The invention relates to the technical field of diabetes treatment, in particular to a tablet for promoting digestion and metabolism for diabetes treatment and a preparation method thereof. Background Art

[0002] Diabetes is a common metabolic disease that usually causes long-term high blood sugar levels due to insufficient insulin secretion or poor insulin action. Depending on the different causes and manifestations, diabetes is divided into several types: type 1 diabetes, type 2 diabetes, gestational diabetes, and other types of diabetes. Treatment of diabetes includes lifestyle management, medication, and regular monitoring of blood sugar.

[0003] The digestive and metabolic processes of people with diabetes are affected in many ways, mainly due to chronically elevated blood sugar levels and insulin dysfunction. The following are specific effects of diabetes on digestion and metabolism: 1. Impact on digestive function: 1.1. Delayed gastric emptying: Diabetic patients, especially those with long-term hyperglycemia, may experience gastroparesis, which is delayed gastric emptying. This is because high blood sugar can damage the nerves that control gastrointestinal motility, causing the stomach to empty more slowly. Symptoms may include nausea, vomiting, bloating, and postprandial discomfort. 1.2. Gastrointestinal motility problems: Diabetes may also affect the smooth muscle function of the intestine, leading to problems such as indigestion, constipation or diarrhea, which are related to poor blood sugar control and autonomic neuropathy; 1.3. Abnormal gastric acid secretion: Diabetic patients may have abnormal gastric acid secretion, resulting in excessive or insufficient gastric acid, which in turn affects the digestion process. Long-term abnormal gastric acid may also lead to problems such as gastroesophageal reflux disease (GERD).

[0004] 2. Impact on metabolic function: 2.1. Insulin resistance and metabolic disorders: In patients with type 2 diabetes, insulin cannot effectively act on cells, resulting in the inability of glucose to enter cells, which causes hyperglycemia. In response to hyperglycemia, the pancreas secretes more insulin. Long-term high insulin levels (excess insulin) may lead to fat accumulation and increase the risk of obesity. 2.2. Lipodystrophy: Due to the weakened effect of insulin, fat cells cannot normally utilize fat reserves, resulting in fat accumulation, especially in the abdomen. High blood sugar and excessive insulin can also lead to the release of fatty acids in adipose tissue and increase the level of inflammation in the body, further aggravating diabetes-related metabolic disorders. 2.3. Glycogen synthesis and decomposition disorders: The liver of diabetic patients may have abnormalities in glycogen synthesis and decomposition. Under normal circumstances, insulin promotes glycogen synthesis and inhibits glycogen decomposition, but in diabetic patients, the effect of insulin is weakened, causing the liver to overproduce glucose, further exacerbating hyperglycemia; 2.4. Protein metabolism disorder: Diabetes can affect protein metabolism, leading to an imbalance in muscle breakdown and synthesis. Long-term high blood sugar levels can lead to a decrease in muscle mass, affecting physical strength and function. 2.5. Microvascular damage and metabolic imbalance: Microvascular damage caused by long-term hyperglycemia can affect the metabolic functions of various organs in the body, including the kidneys, eyes, and nervous system. This damage can affect the transport of substances and the normal metabolism of cells, leading to further imbalance of metabolic function.

[0005] In summary, promoting digestion and metabolism plays an important role in the treatment of diabetes. Promoting digestion and metabolism mainly works by helping to better control blood sugar levels, improving insulin sensitivity, reducing weight and improving overall health.

[0006] Existing diabetes treatment drugs and methods on the market mainly focus on controlling blood sugar levels. However, there are relatively few treatment options for the digestion and metabolism problems of diabetic patients, especially delayed gastric emptying, gastrointestinal motility problems and metabolic dysfunction. Therefore, it is of great clinical significance to develop a drug that can effectively promote the digestion and metabolism of diabetic patients and help control blood sugar levels. Summary of the invention

[0007] The object of the present invention is to provide a tablet for promoting digestion and metabolism for treating diabetes and a preparation method thereof, so as to solve the problems in the above-mentioned background technology.

[0008] To achieve the above object, the present invention provides the following technical solutions: In a first aspect, the present invention provides a tablet for promoting digestion and metabolism for the treatment of diabetes, wherein the components and contents thereof are as follows in terms of mass fraction: 45-65 parts of metformin hydrochloride, 0.001-0.003 parts of vitamin D, 3.5-6 parts of cinnamon extract, 7-12 parts of wolfberry extract, 0.5-1.6 parts of honey, 3-7 parts of starch, 0.4-0.6 parts of polyvinyl pyrrolidone, 0.1-0.3 parts of magnesium stearate, 6-11 parts of filler, 3-9 parts of mineral supplement, and 2-8 parts of dietary fiber.

[0009] Preferably, the mass ratio of the cinnamon extract to the wolfberry extract is 1:2.

[0010] Preferably, the mineral supplement is one or more of magnesium, zinc, calcium and potassium.

[0011] Preferably, the dietary fiber is one or more of β-glucan, arabinose, pectin and mannan.

[0012] Preferably, the filler is one or more of microcrystalline cellulose, hydroxypropyl methylcellulose, and calcium diacid.

[0013] Preferably, the tablet further comprises fish oil and spirulina.

[0014] Preferably, the weight proportions of the fish oil and spirulina are 16 to 25 parts of fish oil and 2 to 8 parts of spirulina.

[0015] The second aspect of the present invention provides a method for preparing the tablet according to the first aspect of the present invention, comprising the following steps: S1, weighing each component in proportion and adding it into a mixing mixer, mixing and stirring until wet granules are formed and have good adhesion; S2, drying the wet granules using a fluidized bed dryer; S3, using a tablet press to compress the dried granules into tablets, ensuring that the thickness and hardness of the tablets meet the standards.

[0016] Preferably, the drying temperature is 40-50°C.

[0017] The present invention has at least the following beneficial effects: The present invention provides a tablet for promoting digestion and metabolism for the treatment of diabetes and a preparation method thereof. The preparation method is simple, the components have strong synergistic effects, and the tablet is suitable for use by a wide range of diabetic patients. It not only effectively controls blood sugar levels, but also significantly promotes the digestion and metabolic functions of diabetic patients, and has broad market prospects and clinical application value. DETAILED DESCRIPTION

[0018] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0019] The present invention provides a tablet for promoting digestion and metabolism for treating diabetes, wherein the components and contents thereof are as follows in parts by mass: 45-65 parts of metformin hydrochloride, 0.001-0.003 parts of vitamin D, 3.5-6 parts of cinnamon extract, 7-12 parts of wolfberry extract, 0.5-1.6 parts of honey, 3-7 parts of starch, 0.4-0.6 parts of polyvinyl pyrrolidone, 0.1-0.3 parts of magnesium stearate, 6-11 parts of filler, 3-9 parts of mineral supplement, and 2-8 parts of dietary fiber.

[0020] Among them, the mass ratio of cinnamon extract to wolfberry extract is 1:2; the mineral supplement is one or more of magnesium, zinc, calcium, and potassium; the dietary fiber is one or more of β-glucan, arabinose, pectin, and mannan; the filler is one or more of microcrystalline cellulose, hydroxypropyl methylcellulose, and calcium diacid.

[0021] In addition, the tablet provided by the present invention further comprises fish oil and spirulina, wherein the weight proportions of the fish oil and the spirulina are 16 to 25 parts of fish oil and 2 to 8 parts of spirulina.

[0022] The preparation method of the above tablets comprises the following steps: S1, weighing each component in proportion and adding it into a mixing mixer, mixing and stirring until wet granules are formed and have good adhesion; S2, drying the wet granules by using a fluidized bed dryer at a drying temperature of 40-50°C; S3, using a tablet press to compress the dried granules into tablets, ensuring that the thickness and hardness of the tablets meet the standards.

[0023] The components of the present invention function as follows: Metformin hydrochloride, as the main hypoglycemic ingredient, can reduce blood sugar by inhibiting hepatic glucose output, improving peripheral tissue sensitivity to insulin, and increasing glucose uptake and utilization; Vitamin D helps maintain blood sugar balance, enhances insulin sensitivity, and is beneficial to bone health; Cinnamon extract has the functions of regulating blood sugar, improving insulin sensitivity and promoting digestion; Lycium barbarum extract is rich in antioxidants, which can protect pancreatic β cells, promote insulin secretion, and regulate blood lipids and blood sugar; Honey, as a natural sweetener, not only provides energy, but also helps improve intestinal microecology and promote digestion; Starch, as an excipient, helps form tablets; Polyvinylpyrrolidone and magnesium stearate, as auxiliary ingredients of tablets, play the role of bonding and lubrication respectively, improving the stability and compressibility of tablets; Fillers are used to adjust the volume and weight of tablets to ensure the uniformity and consistency of tablets; Mineral supplements such as magnesium, zinc, calcium, potassium, etc., play an important role in maintaining blood sugar balance, promoting metabolism and bone health; Dietary fiber helps regulate intestinal function, promotes digestion and metabolism; Fish oil and spirulina, as additional nutrients, provide essential fatty acids and trace elements to further promote health and metabolism.

[0024] Based on the above technical solution, the present invention provides the following partial embodiments:

[0025] Example 1 This embodiment provides a tablet for promoting digestion and metabolism for the treatment of diabetes. The components and contents thereof are as follows in parts by mass: 45 parts of metformin hydrochloride, 0.001 parts of vitamin D, 3.5 parts of cinnamon extract, 7 parts of wolfberry extract, 0.5 parts of honey, 3 parts of starch, 0.4 parts of polyvinyl pyrrolidone, 0.1 parts of magnesium stearate, 6 parts of fillers, 3 parts of mineral supplements, and 2 parts of dietary fiber.

[0026] Among them, the mass ratio of cinnamon extract to wolfberry extract is 1:2; the mineral supplement is magnesium; the dietary fiber is β-glucan; and the filler is microcrystalline cellulose.

[0027] The preparation method of the above tablets comprises the following steps: S1, weighing 45 parts of metformin hydrochloride, 0.001 parts of vitamin D, 3.5 parts of cinnamon extract, 7 parts of wolfberry extract, 0.5 parts of honey, 3 parts of starch, 0.4 parts of polyvinyl pyrrolidone, 0.1 parts of magnesium stearate, 6 parts of filler, 3 parts of mineral supplement, and 2 parts of dietary fiber by mass, adding them into a mixing mixer, mixing and stirring until wet granules are formed and have good adhesion; S2, drying the wet granules by using a fluidized bed dryer at a drying temperature of 40°C; S3, using a tablet press to compress the dried granules into tablets, ensuring that the thickness and hardness of the tablets meet the standards.

[0028] Example 2 This embodiment provides a tablet for promoting digestion and metabolism for the treatment of diabetes. The components and contents thereof are as follows in parts by mass: 50 parts of metformin hydrochloride, 0.002 parts of vitamin D, 4 parts of cinnamon extract, 8 parts of wolfberry extract, 0.7 parts of honey, 4 parts of starch, 0.5 parts of polyvinyl pyrrolidone, 0.2 parts of magnesium stearate, 8 parts of filler, 4 parts of mineral supplement, and 5 parts of dietary fiber.

[0029] Among them, the mass ratio of cinnamon extract to wolfberry extract is 1:2; the mineral supplement is zinc; the dietary fiber is arabinose; and the filler is hydroxypropyl methylcellulose.

[0030] The preparation method of the above tablets comprises the following steps: S1, weigh 50 parts of metformin hydrochloride, 0.002 parts of vitamin D, 4 parts of cinnamon extract, 8 parts of wolfberry extract, 0.7 parts of honey, 4 parts of starch, 0.5 parts of polyvinyl pyrrolidone, 0.2 parts of magnesium stearate, 8 parts of filler, 4 parts of mineral supplement, and 5 parts of dietary fiber by mass, add them into a mixing mixer, mix and stir until wet granules are formed and have good adhesion; S2, drying the wet granules by using a fluidized bed dryer at a drying temperature of 45°C; S3, using a tablet press to compress the dried granules into tablets, ensuring that the thickness and hardness of the tablets meet the standards.

[0031] Example 3 This embodiment provides a tablet for promoting digestion and metabolism for the treatment of diabetes. The components and contents thereof are as follows in parts by mass: 55 parts of metformin hydrochloride, 0.0025 parts of vitamin D, 5 parts of cinnamon extract, 10 parts of wolfberry extract, 1.4 parts of honey, 6 parts of starch, 0.55 parts of polyvinyl pyrrolidone, 0.25 parts of magnesium stearate, 10 parts of filler, 8 parts of mineral supplement, and 7 parts of dietary fiber.

[0032] Among them, the mass ratio of cinnamon extract to wolfberry extract is 1:2; the mineral supplement is calcium; the dietary fiber is pectin; and the filler is calcium diacid.

[0033] The preparation method of the above tablets comprises the following steps: S1, weigh 55 parts of metformin hydrochloride, 0.0025 parts of vitamin D, 5 parts of cinnamon extract, 10 parts of wolfberry extract, 1.4 parts of honey, 6 parts of starch, 0.55 parts of polyvinyl pyrrolidone, 0.25 parts of magnesium stearate, 10 parts of filler, 8 parts of mineral supplement, and 7 parts of dietary fiber by mass, add them into a mixing blender, and mix and stir until wet granules are formed and have good adhesion; S2, drying the wet granules by using a fluidized bed dryer at a drying temperature of 47°C; S3, using a tablet press to compress the dried granules into tablets, ensuring that the thickness and hardness of the tablets meet the standards.

[0034] Example 4 This embodiment provides a tablet for promoting digestion and metabolism for the treatment of diabetes. The components and contents thereof are as follows in parts by mass: 65 parts of metformin hydrochloride, 0.003 parts of vitamin D, 6 parts of cinnamon extract, 12 parts of wolfberry extract, 1.6 parts of honey, 7 parts of starch, 0.6 parts of polyvinyl pyrrolidone, 0.3 parts of magnesium stearate, 11 parts of filler, 9 parts of mineral supplement, and 8 parts of dietary fiber.

[0035] Among them, the mass ratio of cinnamon extract to wolfberry extract is 1:2; the mineral supplement is potassium; the dietary fiber is mannan; and the filler is microcrystalline cellulose.

[0036] The preparation method of the above tablets comprises the following steps: S1, weighing 65 parts of metformin hydrochloride, 0.003 parts of vitamin D, 6 parts of cinnamon extract, 12 parts of wolfberry extract, 1.6 parts of honey, 7 parts of starch, 0.6 parts of polyvinyl pyrrolidone, 0.3 parts of magnesium stearate, 11 parts of filler, 9 parts of mineral supplement, and 8 parts of dietary fiber by mass, adding them into a mixing blender, and mixing and stirring until wet granules are formed and have good adhesion; S2, drying the wet granules by using a fluidized bed dryer at a drying temperature of 50°C; S3, using a tablet press to compress the dried granules into tablets, ensuring that the thickness and hardness of the tablets meet the standards.

[0037] Example 5 This embodiment provides a tablet for promoting digestion and metabolism for the treatment of diabetes. It is the same as Embodiment 1, except that it also includes fish oil and spirulina. The weight proportions of fish oil and spirulina are 16 parts of fish oil and 2 parts of spirulina.

[0038] Example 6 This embodiment provides a tablet for promoting digestion and metabolism for the treatment of diabetes. It is the same as Embodiment 2, except that it also includes fish oil and spirulina. The weight proportions of fish oil and spirulina are 18 parts of fish oil and 4 parts of spirulina.

[0039] Example 7 This embodiment provides a tablet for promoting digestion and metabolism for the treatment of diabetes. It is the same as Embodiment 3, except that it also includes fish oil and spirulina. The weight proportions of fish oil and spirulina are 20 parts of fish oil and 6 parts of spirulina.

[0040] Example 8 This embodiment provides a tablet for promoting digestion and metabolism for the treatment of diabetes. It is the same as Embodiment 4, except that it also includes fish oil and spirulina. The weight proportions of fish oil and spirulina are 25 parts of fish oil and 8 parts of spirulina.

[0041] A series of tests were conducted on the products obtained in Examples 1-8 above, and the results are as follows:

[0042] In summary, the present invention cooperates with each other through a variety of beneficial ingredients, not only effectively controls blood sugar levels, but also significantly promotes the digestion and metabolic functions of diabetic patients. The metformin hydrochloride in the tablet, as the main hypoglycemic drug, can effectively reduce blood sugar, while vitamin D, cinnamon extract and wolfberry extract work synergistically to improve insulin sensitivity, promote insulin secretion, regulate blood lipids, and protect pancreatic beta cells. In addition, the addition of ingredients such as honey, dietary fiber, mineral supplements, fish oil and spirulina further enhances the digestion promotion and metabolic regulation functions of the tablet, helps to improve the intestinal microecology of diabetic patients, and promotes nutrient absorption and metabolic waste discharge.

[0043] After testing, the tablets provided by the present invention have excellent performance in terms of dissolution rate, disintegration time, active ingredient content, etc., and can quickly release active ingredients and improve bioavailability. At the same time, the tablets can also significantly reduce the postprandial blood sugar and fasting blood sugar levels of diabetic patients, effectively reduce the content of glycosylated hemoglobin, thereby comprehensively improving the health of diabetic patients.

[0044] The solution provided by the invention has a simple preparation method, strong synergistic effect of various components, is suitable for use by a wide range of diabetic patients, and has broad market prospects and clinical application value.

[0045] The above shows and describes the basic principles, main features and advantages of the present invention. It is obvious to those skilled in the art that the present invention is not limited to the details of the above exemplary embodiments, and that the present invention can be implemented in other specific forms without departing from the spirit or basic features of the present invention. Therefore, no matter from which point of view, the embodiments should be regarded as exemplary and non-restrictive. The scope of the present invention is defined by the appended claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims are included in the present invention.

[0046] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A tablet for promoting digestion and metabolism for the treatment of diabetes, characterized in that: The components and contents are as follows: 45-65 parts of metformin hydrochloride, 0.001-0.003 parts of vitamin D, 3.5-6 parts of cinnamon extract, 7-12 parts of wolfberry extract, 0.5-1.6 parts of honey, 3-7 parts of starch, 0.4-0.6 parts of polyvinyl pyrrolidone, 0.1-0.3 parts of magnesium stearate, 6-11 parts of filler, 3-9 parts of mineral supplement, and 2-8 parts of dietary fiber.

2. A tablet for promoting digestion and metabolism for the treatment of diabetes according to claim 1, characterized in that: The mass ratio of the cinnamon extract to the wolfberry extract is 1:

2.

3. A tablet for promoting digestion and metabolism for treating diabetes according to claim 1, characterized in that: The mineral supplement is one or more of magnesium, zinc, calcium and potassium.

4. A tablet for promoting digestion and metabolism for treating diabetes according to claim 1, characterized in that: The dietary fiber is one or more of β-glucan, arabinose, pectin and mannan.

5. A tablet for promoting digestion and metabolism for treating diabetes according to claim 1, characterized in that: The filler is one or more of microcrystalline cellulose, hydroxypropyl methylcellulose, and calcium diacid.

6. A tablet for promoting digestion and metabolism for treating diabetes according to claim 1, characterized in that: The tablet also includes fish oil and spirulina.

7. A tablet for promoting digestion and metabolism for treating diabetes according to claim 6, characterized in that: The weight proportions of the fish oil and spirulina are 16 to 25 parts of fish oil and 2 to 8 parts of spirulina.

8. The method for preparing a tablet according to any one of claims 1 to 7, characterized in that: The following steps are involved: S1, weighing each component in proportion and adding it into a mixing mixer, mixing and stirring until wet granules are formed and have good adhesion; S2, drying the wet granules using a fluidized bed dryer; S3, using a tablet press to compress the dried granules into tablets, ensuring that the thickness and hardness of the tablets meet the standards.

9. The method for preparing the tablet according to claim 8, characterized in that: The drying temperature is 40-50°C.

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