Control method and equipment of artificial liver blood purification pipeline and medium

Abstract

The invention provides a control method, system and equipment of an artificial liver blood purification pipeline, a medium and a program product, and relates to the field of medical treatment. The method comprises the steps that an instruction for opening or closing at least one component in a pipeline is obtained; changing the flow direction of plasma passing through the pipeline component elements according to the instruction; according to the method, connection and / or disconnection between pipelines are automatically controlled according to different treatment equipment types, so that the flow directions of blood and plasma in the pipelines are controlled, the effect of automatically adapting to multiple treatment modes is achieved, the defect that currently used pipelines can only complete a single corresponding treatment mode is overcome, and the treatment efficiency is improved. The step of assembling multiple sets of pipelines is avoided through the comprehensive automatic control method, the probability of errors and pollution in the pipeline installation process is reduced, the medical cost is reduced, and the workload of medical staff is reduced.

Description

Technical Field

[0001] The present invention relates to the field of intelligent medical treatment, and more specifically, to a control method, device, medium and program product of an artificial liver blood purification pipeline. Background Art

[0002] Artificial liver therapy is an important means of treating liver failure. Relevant guidelines and consensus have pointed out that artificial liver therapy has a definite clinical effect. Its treatment principle is to complete the functions of separation, replacement, adsorption and material exchange through the extracorporeal circulation system, temporarily replace part of the liver function, remove harmful substances, supplement essential substances, create conditions for liver cell regeneration, and can also serve as a bridge for liver transplantation. Commonly used treatment modes include plasma exchange (PE), perfusion (PA), plasma diafiltration (PDF), dual plasma molecular adsorption system (DPMAS), etc.

[0003] Artificial liver treatment is highly operational, and the installation and pre-flushing of the extracorporeal circulation circuit must be completed before treatment, which is a large workload. With the continuous updating of artificial liver blood purification treatment modes and technologies, the existing fixed modes and corresponding circuits cannot fully meet the needs of clinical treatment development and the development of new treatment modes. Therefore, in clinical practice, a complex treatment phenomenon is achieved by splicing multiple sets of circuits, but the method of assembling multiple sets of circuits has certain defects and risks: first, it increases the workload and operation links of the operator and increases the risk of contamination; second, it increases the difficulty of nursing operations, making it difficult to achieve homogeneity in the quality of clinical nursing operations, further increasing the risk of treatment and affecting the safety of treatment; third, the splicing combination of multiple sets of circuits increases the patient's medical expenses. Therefore, a control method for blood purification circuits that can adapt to the current clinical multiple treatment needs and complex mode treatment to a greater extent can achieve the effect of automatically changing the treatment mode. Summary of the invention

[0004] The present invention aims to solve at least one of the technical problems existing in the prior art. To this end, the present invention provides a control method, device, medium and program product for an artificial liver blood purification pipeline; the method of the present invention controls the conduction and disconnection between pipelines according to different types of treatment equipment, thereby controlling the flow direction of blood and plasma in the pipeline, and realizing automatic adaptation to multiple treatment modes.

[0005] In a first aspect, the present application discloses a control method for an artificial liver blood purification circuit, the method comprising: Obtaining an instruction to open or close at least one component in a pipeline; the pipeline includes: an input component, a secondary membrane separator, a second connecting pipe, a third connecting pipe, a filtration pump P3, and an output component; the input component is connected to the lower end of the secondary membrane separator, the upper end of the secondary membrane separator is connected to the filtration pump P3 through the second connecting pipe, the secondary membrane separator body is provided with a port 1 and a port 2, and the port 1 is connected to the output component through the third connecting pipe; the component includes a disconnection interface 1 provided at the second connecting pipe and a disconnection interface 2 provided at the third connecting pipe; The flow direction of the plasma flowing out after passing through the output component is changed according to the instruction; when the disconnect interface 1 and the disconnect interface 2 are opened, the S1 interface located at the disconnect interface 1 is connected with the S6 interface of the disconnect interface 2, so as to control the plasma passing through the secondary membrane separator to flow into the output component; and the S2 interface located at the disconnect interface 1 is connected with the S5 interface of the disconnect interface 2, so as to control the plasma passing through the secondary membrane separator to flow out along the port 1 and flow into the port 2 through the filtration pump P3.

[0006] In some embodiments, controlling the plasma that has passed through the secondary membrane separator to flow into the output component comprises: controlling the plasma that has passed through the secondary membrane separator to flow into the output component from the upper end of the secondary membrane separator sequentially through the S1 interface and the S6 interface; Optionally, port one is located at a lower end of port two.

[0007] In some embodiments, the pipeline further includes: a connecting tube 4 arranged at port 2, a T-tube 1 arranged at the connecting tube 4, a processing device, a waste liquid tube 2 arranged at the filtration pump P3, and a disconnection interface 3 is arranged at the waste liquid tube 2; opening the disconnection interface 1 and the disconnection interface 2 is a first treatment mode, and the first treatment mode further includes: obtaining an instruction to open the T-tube 1, controlling the plasma passing through the secondary membrane separator to flow into the secondary membrane separator along the port 1 in sequence through the S5 interface, the S2 interface, the filtration pump P3, the disconnection interface 3, the processing device, the T-tube 1, and the port 2; after flowing into the secondary membrane separator along the port 2, it flows from the secondary membrane separator from top to bottom, and flows out along the port 1 on the side of the secondary membrane separator body, and the liquid after flowing out flows into the filtration pump P3 through the S5 interface and the S2 interface to form a self-circulation; Optionally, the processing device includes any one of the following: a biological device, a non-biological adsorption device, and a perfusion device.

[0008] Optionally, the pipeline also includes a connecting tube 1 arranged at the lower end of the input component and the lower end of the secondary membrane separator, and a waste liquid tube 1 connected to the connecting tube 1; the component also includes a T-tube 2 arranged at the connection between the connecting tube 1 and the waste liquid tube 1; when the instructions to close the disconnect interface 1 and the disconnect interface 2 and the instructions to close the T-tube 1 and the T-tube 2 are obtained, the second treatment mode is turned on, and the plasma passing through the secondary membrane separator is controlled to be discharged from the upper end of the secondary membrane separator through the connecting tube 2, the filtration pump P3, and the waste liquid tube 2 in sequence; at the same time, the plasma passing through the input component is also controlled to flow directly into the secondary membrane separator through the connecting tube 1.

[0009] Optionally, the second treatment mode also includes: controlling the plasma flowing out of port one to flow into the output component through connecting tube three.

[0010] In some embodiments, the pipeline further includes: a fluid infusion pot; the output component includes a return plasma pump P4, a venous pot, and an outlet venous tube; the input component includes: a primary membrane separator and a plasma pot; the lower end of the primary membrane separator is sequentially connected to the venous pot and the first end of the outlet venous tube through a connecting pipe; the fluid infusion pot, the return plasma pump P4 and the venous pot are sequentially connected through a connecting pipe; the lower end of the plasma pot is connected to the lower end of the secondary membrane separator through a connecting pipe 1, and the port 1 of the secondary membrane separator is sequentially connected to the venous pot through a connecting pipe 2, the return plasma pump P4 and a connecting pipe 5; Optionally, the components also include a multi-port tube arranged at connecting tube three and a T-tube three arranged at connecting tube five; when an instruction to open disconnect interface one, the multi-port tube, and T-tube three is obtained, the third treatment mode is turned on to control the plasma to flow into the multi-port tube, T-tube three, connecting tube five, and then into the venous pot in sequence through the S1 interface of connecting tube two.

[0011] Optionally, the multi-port tube has at least five ports, the first port is used to connect to the S1 interface at the connecting tube 2, the second port is used to connect to the port 1 of the secondary membrane separator, the third port is used to connect to the T-tube 3, the fourth port is used to connect to the liquid replenishment pot, and the fifth port is used to connect to the return slurry pump P4.

[0012] In some embodiments, when an instruction to start the second T-tube is obtained, the fourth treatment mode is started, and the plasma after the plasma passes through the plasma pot is controlled to be discharged as waste plasma through the waste liquid pipe 1; Optionally, the fourth treatment mode also includes: obtaining a connecting tube between the fluid infusion pot, the slurry pump P4 and the venous pot in the conductive multi-port tube, and controlling the nutrient solution in the fluid infusion pot to flow into the venous pot after passing through the slurry pump P4; the speed at which the nutrient solution flows into the venous pot is consistent with the speed at which the waste plasma is discharged; the nutrient solution is a supplementary solution / replacement solution, and the nutrient solution includes one or more of the following: plasma, albumin solution, colloid solution, plasma bag supplies, and balancing solution.

[0013] In some embodiments, the component also includes a disconnect interface four arranged between the T-tube three of the connecting tube five and the venous pot; when an instruction to open the disconnect interface four is obtained, an S7 interface and an S8 interface are formed on both sides of the disconnect interface four.

[0014] In some embodiments, the input component further includes: an inlet artery tube, a blood pump P1, an arterial pot, a primary membrane separator, and a plasma pump P2; the output component further includes an outlet venous tube; the first end of the inlet arterial tube is connected to the patient, the second end of the inlet arterial tube is sequentially connected to the blood pump P1, the arterial pot, and the upper end of the primary membrane separator through a connecting tube, and the body side port 2 of the primary membrane separator is sequentially connected to the plasma pump P2 and the upper end of the plasma pot through a connecting tube; the return plasma pump P4 is connected to the first end of the outlet venous tube, and the second end of the outlet venous tube is connected to the patient; In some embodiments, the first treatment mode is a treatment mode when a novel secondary adsorption treatment device is used; Optionally, the second treatment mode is a treatment mode when a DFPP treatment device is used; Optionally, the third treatment mode is a treatment mode when a DPMAS treatment device is used; Optionally, the fourth treatment mode is a treatment mode when a PE treatment device is used; In some embodiments, the disconnection interfaces at both ends of the disconnection interface are respectively provided with stop valves or stop clamps for connecting the disconnection interfaces with other pipelines.

[0015] The third aspect of the present application discloses a computer device, which includes: a memory and a processor; the memory is used to store a computer program; and the processor executes the computer program to implement the steps of the above method.

[0016] A fourth aspect of the present application discloses a computer-readable storage medium having a computer program stored thereon, wherein the computer program implements the steps of the above method when executed by a processor.

[0017] A fifth aspect of the present application discloses a computer program product, including a computer program, which implements the steps of the above method when executed by a processor.

[0018] This application has the following beneficial effects: 1. This application innovatively discloses a control method for an artificial liver blood purification pipeline, which automatically controls the conduction and / or disconnection between pipelines according to different types of treatment equipment, thereby controlling the flow direction of blood and plasma in the pipeline, achieving the effect of automatically adapting to multiple treatment modes, overcoming the defect that the currently used pipelines can only complete a single corresponding treatment mode. The fully automated control method avoids the steps of assembling multiple sets of pipelines, reduces the probability of errors and contamination during pipeline installation, reduces medical costs, and reduces the workload of medical staff. It is worth noting that the four treatment modes in this application are parallel treatment modes that do not interfere with each other.

[0019] 2. The present application innovatively adopts a separate design for the pipes connecting the individual components in the extracorporeal circulation circuit, adds a detachable spiral interface to the separation fracture, and sets a T-tube somewhere in the pipe to increase the liquid flow direction, etc., in order to solve the problem that each single treatment mode can only use its own unique set of pipes, resulting in the inability to replace some defective pipes and high costs.

[0020] 3. The control method and corresponding pipeline disclosed in this application also have the following advantages: 1) Reduce work links: A set of pipelines can realize the free switching of multiple treatment modes, avoiding the current situation where two sets of pipelines need to be pieced together to complete complex modes, and avoiding the situation where the automatic pre-flushing program of the artificial liver blood purification machine cannot be used to complete the pre-flushing due to the splicing of pipelines. First, it reduces the use of consumables. Second, it avoids human intervention in manual pre-flushing and reduces the possibility of contamination. Third, it reduces the difficulty of installation and pre-flushing operations, which is conducive to improving operability, rapid homogeneous promotion, and improving treatment safety.

[0021] 2) Applicable to multiple modes: In addition to being applicable to a variety of mature modes of artificial liver treatment, the improved pipeline is also suitable for the development of new secondary adsorption / pipeline / bio-artificial liver treatment.

[0022] 3) Replaceable venous pots and tubing: Due to changes in the artificial liver blood purification treatment mode, the complexity increases, the treatment time is prolonged, and the treatment may even last for more than 8 hours. Therefore, the incidence of thrombosis in the extracorporeal circulation circuit, especially in the venous pot, will also increase with time. It manifests as increased instrument pressure during treatment, and even coagulation and blockage of the pipeline, resulting in the inability to achieve the expected treatment goals and unplanned machine removal; consumption of coagulation substances such as platelets, increasing the risk of bleeding during treatment; and causing economic losses. Based on this, a venous tubing designed to be replaceable can avoid the above situation.

[0023] The design of connectable ends in the venous line breaks the traditional one-piece line form, and the independent parts of the line assembly can be replaced in the early stage of venous thrombosis, avoiding the need to replace the primary membrane, secondary membrane and the entire set of treatment lines due to blockage of the venous line. This method can reduce medical costs and patient expenses; reduce adverse events such as blood loss and coagulation substance consumption caused by line coagulation; and reduce the workload and time cost of operators to reinstall and pre-flushing the line.

[0024] 4) Convenient management: Liver failure patients are in critical condition and their conditions change rapidly. The treating physician will temporarily change the treatment plan and treatment mode according to the progression of the disease, and will also carry out emergency treatment when necessary. There are many types of non-bioartificial liver treatments, and different treatment modes require the use of corresponding extracorporeal circulation circuits. On the one hand, it will cause the department to have a large number of pipeline consumables in storage, and on the other hand, it is easy for the pipeline to expire or the pipeline models to be incomplete and the supply to be insufficient. In this case, it not only increases the workload of management personnel, but also affects the timely treatment of patients. The improved pipeline can be used for multiple treatment modes with one set of pipelines, reducing management pressure. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative work.

[0026] Figure 1 is a schematic diagram of a method flow chart provided by the first aspect of an embodiment of the present invention; Figure 2 It is a schematic diagram of a control system of an artificial liver blood purification pipeline provided by the second aspect of an embodiment of the present invention; Figure 3 is a schematic diagram of a computer device provided by an embodiment of the present invention; Figure 4 is a schematic diagram of the architecture of an exemplary computing device provided by an embodiment of the present invention; Figure 5 is a schematic diagram of a storage medium provided by an embodiment of the present invention; Figure 6 is a schematic diagram of pipeline connection in a first treatment mode provided by an embodiment of the present invention; Figure 7 is a schematic diagram of pipeline connection in a second treatment mode provided by an embodiment of the present invention; Figure 8 is a schematic diagram of pipeline connections in a third treatment mode provided by an embodiment of the present invention; Fig. 9 is a schematic diagram of pipeline connections in a fourth treatment mode provided by an embodiment of the present invention; 1. Arterial pot; 2. Primary membrane separator; 3. Plasma pot; 31. Connecting tube one; 32. Waste liquid tube one; 33. T-tube two; 4. Secondary membrane separator; 41. Connecting tube two; 411. Disconnection interface one; 42. Connecting tube three; 421. Disconnection interface two; 422. Multi-port tube; 43. Connecting tube four; 431. T-tube one; 44. Waste liquid tube two; 441. Disconnection interface three; 45. Port one; 46. Port two; 5. Processing device; 6. Rehydration pot; 7. Venous pot; 8. Connecting tube five; 81. T-tube three; 82. Disconnection interface four. DETAILED DESCRIPTION

[0027] In order to enable those skilled in the art to better understand the solutions of the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention.

[0028] In some of the processes described in the specification and claims of the present invention and the above-mentioned figures, multiple operations that appear in a specific order are included, but it should be clearly understood that these operations may not be executed in the order in which they appear in this article or executed in parallel. The serial numbers of the operations, such as 101, 102, etc., are only used to distinguish different operations, and the serial numbers themselves do not represent any execution order. In addition, these processes may include more or fewer operations, and these operations may be executed in sequence or in parallel. It should be noted that the descriptions of "first", "second", etc. in this article are used to distinguish different messages, devices, modules, etc., do not represent the order of precedence, and do not limit the "first" and "second" to be different types.

[0029] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative work are within the scope of protection of the present invention.

[0030] Figure 1 The present invention provides a flow chart of a control method for an artificial liver blood purification pipeline. Specifically, the method comprises the following steps: 101: Obtaining an instruction to open or close at least one component in a pipeline; the pipeline includes: an input component, a secondary membrane separator, a second connecting pipe, a third connecting pipe, a filtration pump P3, and an output component; the input component is connected to the lower end of the secondary membrane separator, the upper end of the secondary membrane separator is connected to the filtration pump P3 through the second connecting pipe, the secondary membrane separator body is provided with a port 1 and a port 2, and the port 1 is connected to the output component through the third connecting pipe; the component includes a disconnection interface 1 provided at the second connecting pipe and a disconnection interface 2 provided at the third connecting pipe; 102: changing the flow direction of the plasma flowing out of the output component according to the instruction; when the disconnection interface 1 and the disconnection interface 2 are opened, the S1 interface located at the disconnection interface 1 is connected with the S6 interface of the disconnection interface 2, so as to control the plasma passing through the secondary membrane separator to flow into the output component; and the S2 interface located at the disconnection interface 1 is connected with the S5 interface of the disconnection interface 2, so as to control the plasma passing through the secondary membrane separator to flow out along the port 1 and flow into the port 2 through the filtration pump P3; In some embodiments, controlling the plasma that has passed through the secondary membrane separator to flow into the output component comprises: controlling the plasma that has passed through the secondary membrane separator to flow into the output component from the upper end of the secondary membrane separator sequentially through the S1 interface and the S6 interface; Optionally, port one is located at a lower end of port two.

[0031] In some embodiments, the pipeline further includes: a connecting tube 4 arranged at port 2, a T-tube 1 arranged at the connecting tube 4, a processing device, a waste liquid tube 2 arranged at the filtration pump P3, and a disconnection interface 3 is arranged at the waste liquid tube 2; opening the disconnection interface 1 and the disconnection interface 2 is a first treatment mode, and the first treatment mode further includes: obtaining an instruction to open the T-tube 1, controlling the plasma passing through the secondary membrane separator to flow into the secondary membrane separator along the port 1 in sequence through the S5 interface, the S2 interface, the filtration pump P3, the disconnection interface 3, the processing device, the T-tube 1, and the port 2; after flowing into the secondary membrane separator along the port 2, it flows from the secondary membrane separator from top to bottom, and flows out along the port 1 on the side of the secondary membrane separator body, and the liquid after flowing out flows into the filtration pump P3 through the S5 interface and the S2 interface to form a self-circulation; Optionally, the processing device includes any one of the following: a biological device, a non-biological adsorption device, and a perfusion device.

[0032] When undescribed components are involved, the default undescribed components are the default original state of the treatment mode. For example, when the first treatment mode is turned on, the undescribed T-tube 2 controls the unobstructed connection between the plasma pot and the secondary membrane separator, and the liquid in the connection tube 1 does not flow into the waste liquid tube 1; when there is no need to replace the venous pot and the circuit separately, the disconnection interface 4 of the connection tube 5 remains unobstructed; the infusion pot continues to replenish liquid through the connection tube without the return plasma pump, etc. For details, refer to Figure 6 shown.

[0033] Specifically, Figure 6 As shown, the treatment device also includes: a stop clamp arranged at the first end of the inlet arterial tube, and a pipeline connecting the fluid infusion port and the pressure detection port is also arranged on the inlet arterial tube, and a stop clamp is arranged on each of the two pipelines; a pipeline connecting the anticoagulation pump and a pipeline connecting the pressure detection port are sequentially arranged on the pipeline connecting the blood pump and the arterial pot, and a stop clamp is arranged on each of the two pipelines, and a T-tube is arranged at the connection between the pipeline between the blood pump and the arterial pot and the pipeline connecting the anticoagulation pump. Two ports are respectively arranged on the side of the primary membrane separator body, the lower port is connected to the slurry pump, and the upper port is connected to the pipeline with a stop clamp and a pressure detection port; a blood leakage detection structure is arranged between the primary membrane separator and the slurry pump; a pipeline connected to the pressure detection port with a stop clamp is arranged at the upper end of the plasma pot; the secondary membrane separator is a secondary membrane secondary membrane separator, and the pipeline connected to the port one of the secondary membrane secondary membrane separator is sequentially arranged with a sampling / drug administration port and a stop clamp, and is detachably connected to the connecting pipe four; a T-tube is arranged on the pipeline connected to the port two of the secondary membrane secondary membrane separator, and another pipeline is arranged through the T-tube to communicate with the processing device, and the connected pipelines are sequentially arranged with a sampling / drug administration port and a stop clamp; a pressure detection port of the pipeline with a stop clamp is also arranged through the T-tube; the connecting pipe four is connected to the break of the connecting pipe two, and a stop clamp is arranged at the break of the connecting pipe two; a stop clamp is arranged on the connecting pipeline of the filtration pump P3 and the processing device, and the pipeline connected to the waste liquid pipe two can be disconnected to prevent the liquid passing through the filtration pump from flowing to the waste liquid pipe two for discharge. At the same time, another break of the connecting pipe 2 at the upper end of the secondary membrane separator is connected to the connecting pipe 3, and the other end of the connecting pipe 3 is connected to the return slurry pump P4; other locations of the stop clamp, T-tube, disconnection point, sampling / dosing port are set on the pipeline as follows Figure 6 shown.

[0034] In some embodiments, the pipeline also includes a connecting tube 1 arranged at the lower end of the input component and the lower end of the secondary membrane separator, and a waste liquid tube 1 connected to the connecting tube 1; the component also includes a T-tube 2 arranged at the connection between the connecting tube 1 and the waste liquid tube 1; when the instructions to close the disconnect interface 1 and the disconnect interface 2 and the instructions to close the T-tube 1 and the T-tube 2 are obtained, the second treatment mode is turned on, and the plasma passing through the secondary membrane separator is controlled to be discharged from the upper end of the secondary membrane separator through the connecting tube 2, the filtration pump P3, and the waste liquid tube 2 in sequence; at the same time, the plasma passing through the input component is also controlled to flow directly into the secondary membrane separator through the connecting tube 1.

[0035] Optionally, the second treatment mode also includes: controlling the plasma flowing out of port one to flow into the output component through connecting tube three.

[0036] Optionally, the second treatment device further controls the plasma flowing out of the secondary membrane separator body side port 1 to flow into the return plasma pump P4. Optionally, the second treatment device is a DFPP treatment device; specifically, Figure 7 As shown, port 1 at the lower end of the secondary membrane separator is directly connected to the return slurry pump P4, and port 2 at the lower end of the secondary membrane separator is connected to the pressure detection port.

[0037] When it comes to undescribed components, the undescribed components are assumed to be in the default original state of the treatment mode. For example, when the second treatment mode is turned on, the undescribed disconnect interface 1 and disconnect interface 2 remain unobstructed, the liquid output from the upper end of the secondary membrane separator flows into the P3 pump through the connecting tube 2 and then discharged through the waste liquid tube 2, the liquid through the secondary membrane separator port 1 flows into the return pump P4 through the connecting tube 3, and the liquid through the secondary membrane separator port 2 is detected by the pressure detection port through the connecting tube 4; the undescribed T-tube 2 controls the unobstructed connection tube 1 between the plasma pot and the secondary membrane separator, and the liquid in the connecting tube 1 does not flow into the waste liquid tube 1; when there is no need to replace the venous pot and the circuit separately, the disconnect interface 4 of the connecting tube 5 remains unobstructed; the infusion pot continues to be replenished with liquid through the connecting tube without the return pump, etc. For details, refer to Figure 7 shown.

[0038] In some embodiments, the pipeline further includes: a fluid infusion pot; the output component includes a return plasma pump P4, a venous pot, and an outlet venous tube; the input component includes: a primary membrane separator and a plasma pot; the lower end of the primary membrane separator is sequentially connected to the venous pot and the first end of the outlet venous tube through a connecting pipe; the fluid infusion pot, the return plasma pump P4 and the venous pot are sequentially connected through a connecting pipe; the lower end of the plasma pot is connected to the lower end of the secondary membrane separator through a connecting pipe 1, and the port 1 of the secondary membrane separator is sequentially connected to the venous pot through a connecting pipe 2, the return plasma pump P4 and a connecting pipe 5; Optionally, the components also include a multi-port tube arranged at connecting tube three and a T-tube three arranged at connecting tube five; when an instruction to open disconnect interface one, the multi-port tube, and T-tube three is obtained, the third treatment mode is turned on to control the plasma to flow into the multi-port tube, T-tube three, connecting tube five, and then into the venous pot in sequence through the S1 interface of connecting tube two.

[0039] Optionally, the multi-port tube has at least five ports, the first port is used to connect to the S1 interface at the connecting tube 2, the second port is used to connect to the port 1 of the secondary membrane separator, the third port is used to connect to the T-tube 3, the fourth port is used to connect to the liquid replenishment pot, and the fifth port is used to connect to the return slurry pump P4.

[0040] Optionally, the third treatment device is a DPMAS treatment device. Specifically, Figure 8 As shown, there is no port design on the side of the secondary membrane separator, and the plasma passing through the plasma pot directly flows out from bottom to top along the secondary membrane separator. The secondary membrane separator can be: a secondary membrane, a perfusion device, an adsorber, a filter, a cell filter, etc.

[0041] When it comes to undescribed components, the undescribed components are assumed to be in the default original state of the treatment mode. For example, when the third treatment mode is turned on, port 1 and port 2 on the body side of the secondary membrane separator are directly closed, and the liquid only flows in from the lower end of the perfusion device and then flows out from the upper end. Through the connection of the broken end interface, it flows into the connecting tube 5 through the disconnect interface 1. The S2 interface and the subsequent filtration pump P3, waste liquid pipe 2, processing equipment, etc. are directly closed; the infusion pot and the return slurry pump P4 are also directly closed; the undescribed T-tube 2 controls the unobstructed connection tube 1 between the plasma pot and the secondary membrane separator, and the liquid in the connection tube 1 does not flow into the waste liquid pipe 1; when there is no need to replace the venous pot and the circuit separately, the disconnect interface 4 of the connection tube 5 remains unobstructed; the infusion pot continues to replenish liquid through the connecting tube without the return slurry pump, etc. For details, refer to Figure 8 shown.

[0042] In some embodiments, when an instruction to start the second T-tube is obtained, the fourth treatment mode is started, and the plasma after the plasma passes through the plasma pot is controlled to be discharged as waste plasma through the waste liquid pipe 1; Optionally, the fourth treatment mode also includes: obtaining a connecting tube between the fluid infusion pot, the slurry pump P4 and the venous pot in the conductive multi-port tube, and controlling the nutrient solution in the fluid infusion pot to flow into the venous pot after passing through the slurry pump P4; the speed at which the nutrient solution flows into the venous pot is consistent with the speed at which the waste plasma is discharged; the nutrient solution is a supplementary solution / replacement solution, and the nutrient solution includes one or more of the following: plasma, albumin solution, colloid solution, plasma bag supplies, and balancing solution.

[0043] When undescribed components are involved, the default undescribed components are the default original state of the treatment mode. For example, when the fourth treatment mode is turned on, the plasma only flows from the lower end of the plasma pot through the connecting tube 1, T-tube 2, and waste liquid pipe 1 in sequence, and other undescribed reaching pipes and components are directly closed; when there is no need to replace the intravenous pot and the circuit separately, the disconnection interface 4 of the connecting tube 5 remains unobstructed; the infusion pot continues to replenish liquid through the connecting tube without the return plasma pump, etc. For details, refer to Fig. 9 shown.

[0044] In some embodiments, the component also includes a disconnect interface four arranged between the T-tube three of the connecting tube five and the venous pot; when an instruction to open the disconnect interface four is obtained, an S7 interface and an S8 interface are formed on both sides of the disconnect interface four.

[0045] In some embodiments, opening the disconnection interface means that the disconnection interface is disconnected to form an interface with 2 and a broken end, and closing the disconnection interface means that the disconnection interface is turned on and there is no broken end interface.

[0046] In some embodiments, the input component further includes: an inlet artery tube, a blood pump P1, an arterial pot, a primary membrane separator, and a plasma pump P2; the output component further includes an outlet venous tube; the first end of the inlet arterial tube is connected to the patient, the second end of the inlet arterial tube is sequentially connected to the blood pump P1, the arterial pot, and the upper end of the primary membrane separator through a connecting tube, and the body side port 2 of the primary membrane separator is sequentially connected to the plasma pump P2 and the upper end of the plasma pot through a connecting tube; the return plasma pump P4 is connected to the first end of the outlet venous tube, and the second end of the outlet venous tube is connected to the patient; In some embodiments, the first treatment mode is a treatment mode when a novel secondary adsorption treatment device is used; Optionally, the second treatment mode is a treatment mode when a DFPP treatment device is used; Optionally, the third treatment mode is a treatment mode when a DPMAS treatment device is used; Optionally, the fourth treatment mode is a treatment mode when a PE treatment device is used; In some embodiments, the corresponding type of treatment device is turned on according to the treatment mode required by the subject. The terms "subject" or "subject to be tested" or "sample to be tested" used herein refer to any animal (e.g., mammal), including but not limited to humans, non-human primates, rodents, etc., which will become the recipient of a specific treatment. Generally, the terms "subject" and "patient" are used interchangeably herein when referring to human subjects. Preferably, the subject is a human.

[0047] In some embodiments, the disconnection interfaces at both ends of the disconnection interface are respectively provided with stop valves or stop clamps for connecting the disconnection interfaces with other pipelines.

[0048] exist Figure 6-9 In the figure, the stop clamp is shaped like the number 8, the pressure detection port is shaped like an equilateral pentagon, the T-tube is represented by T, and a sampling / drug administration port is provided on the pipeline, which is shaped like an ellipse. Specific embodiment:

[0050] 1. Transformation (1) A split design is adopted for the secondary membrane inlet side of the extracorporeal circulation circuit, and detachable spiral interfaces are added on both sides of the broken end.

[0051] (2) A T-tube and a broken-end spiral interface design are added to the side hole at the upper end of the secondary membrane of the extracorporeal circulation circuit.

[0052] (3) A separation design is added to the side hole at the lower end of the secondary membrane of the extracorporeal circulation circuit, and a detachable spiral interface is added on both sides of the broken end.

[0053] (4) Add a cross-shaped connecting pipe design in front of the P4 pump to increase the liquid flow direction.

[0054] (5) A separate design is adopted between the venous circuit catheter, the warmer and the venous pot, and a detachable spiral interface is added on both sides of the cut end.

[0055] (6) A T-tube and extension tube design is added after the P4 pump, which can be connected to the cross-shaped structure.

[0056] (7) After the P3 pump, the waste liquid pipe has a separate design and detachable spiral interfaces are added on both sides of the broken end.

[0057] (8) Add flow-stop clamps on both sides of the added break end design.

[0058] 2. Technical solution

[0059] 2.1 Structure, connection and function: (1) The secondary membrane inlet side pipeline is designed to be split, with D1 as the separation point, forming two ends S1 and S2.

[0060] Connection: S1 and S6 connection; S2 and S5 connection Function: S1 and S6 are connected, so that the plasma in the secondary membrane can be drawn out from the outlet side of the secondary membrane and enter the vein through the P4 pump. S2 and S5 are connected, so that the plasma in the secondary membrane can be drawn out from the side hole at the lower end of the secondary membrane and flow to the direction of the P3 pump.

[0061] (2) A T-shaped tube is added to the side hole at the upper end of the secondary membrane to form two broken ends, S3 and S4.

[0062] Connection: The S4 end is connected to the outlet side of M3, and the S3 end is free at this time; M3 is a processing device; Function: The substances passing through M3 enter the upper end of the side hole of the secondary membrane through the T-tube and enter the outside of the secondary membrane.

[0063] (3) The side holes at the lower end of the secondary membrane are designed to be separated, with D3 as the separation point, forming two ends S5 and S6.

[0064] The connection and function are the same as (1).

[0065] (4) Add a T5 cross-shaped connecting pipe design on the upper side of the P4 pump.

[0066] Connection: Can be connected to T6, can be connected to fluid infusion.

[0067] Function: Connected with T6 to form a plasma return bypass, allowing plasma to return to the vein (applicable during DPMAS treatment). Connected with fluid replacement to allow fluid replacement to return to the vein via the P4 pump.

[0068] (5) With D4 as the separation point, two ends S7 and S8 are formed.

[0069] Function: It can be connected to an independent venous line to achieve separate replacement of the venous pot and circuit.

[0070] (6) A T-tube and an extension tube are added after the P4 pump, which can be connected to the T5 cross-shaped structure. The function is the same as (4).

[0071] (7) With D2 as the separation point, two ends S3 and S4 are formed.

[0072] Connection: S3 is connected to the inlet side of M3.

[0073] Function: S3 is connected to the inlet side of M3, so that plasma can be drawn out from the lower end of the side hole of M2 and then enter M3 through the P3 pump. M2 is a two-stage membrane separator; (8) T-tube structure: For example, the upper end T4 of the secondary membrane side hole has a T-shaped design, so that one end is connected to a pressure sensor to detect the pressure outside the membrane. A section of the pipeline is extended at the opening on the other side and a spiral opening design is added to achieve connection with other non-biological perfusion / adsorption devices or bioreactor devices. For details, please refer to Figure 6-9 , is a simple schematic diagram.

[0074] 2.3 Treatment principle: 2.3.1 Functions of each component (1) Primary membrane (plasma separator / filter): Its function is to separate part of the plasma from the whole blood.

[0075] (2) Secondary membrane (selective plasma component separator / secondary membrane separator / cell filter, etc.): Its function is to prevent particles / cells and other substances in non-biological perfusion / adsorption devices or bioreactor devices from falling into the blood circulation.

[0076] (3) Non-biological perfusion / adsorption device / bioreactor device: its function is to adsorb toxins / detoxify / complete material exchange, etc.

[0077] (4) Extracorporeal circulation circuit: used to establish extracorporeal circulation for artificial liver blood purification treatment.

[0078] 2.3.2 Principle (1) By disconnecting the separation port after pipeline modification, the upper and lower side holes outside the secondary membrane are connected to the inlet and outlet of the non-biological perfusion / adsorption device / bioreactor device to complete the new artificial liver treatment.

[0079] (2) By adding a detachable spiral interface, the connection method of different interfaces can be changed inside the pipeline, thereby changing the treatment principle and treatment mode, so that one set of pipelines can meet the needs of multiple treatment modes.

[0080] (3) The problem of replacing the venous circuit separately can be solved by designing a detachable connection between the warmer and the venous kettle and adding a detachable spiral interface design.

[0081] (4) When designing the disconnection, add a stop valve at the end of the pipeline to prevent liquid leakage and change the flow direction when the pipeline is disconnected.

[0082] Figure 3 is a schematic diagram of a computer device provided by an embodiment of the present invention, such as Figure 3 As shown, the device may include: one or more processors, and one or more memories; wherein the memories store computer-readable codes, and when the computer-readable codes are run by the one or more processors, the method described above may be executed.

[0083] The processor in this embodiment can be an integrated circuit chip with signal processing capabilities. The above processor can be a general-purpose processor, a digital signal processor (DSP), an application-specific integrated circuit (ASIC), a field-programmable gate array (FPGA) or other programmable logic devices, discrete gates or transistor logic devices, discrete hardware components. The disclosed methods, operations and logic block diagrams in the embodiments of the present disclosure can be implemented or executed. The general-purpose processor can be a microprocessor or the processor can also be any conventional processor, etc., which can be an X86 architecture or an ARM architecture.

[0084] In general, various example embodiments of the present disclosure may be implemented in hardware or dedicated circuits, software, firmware, logic, or any combination thereof. Certain aspects may be implemented in hardware, while other aspects may be implemented in firmware or software that may be executed by a controller, microprocessor, or other computing device. When various aspects of the disclosed embodiments are illustrated or described as block diagrams, flow charts, or using some other graphical representation, it will be understood that the blocks, devices, systems, techniques, or methods described herein may be implemented in hardware, software, firmware, dedicated circuits or logic, general purpose hardware or controllers or other computing devices, or some combination thereof as non-limiting examples.

[0085] For example, the method or device according to the embodiment of the present disclosure may also be implemented by Figure 4 The architecture of the computing device 3000 shown in FIG. Figure 4As shown, the computing device 3000 may include a bus 3010, one or more CPUs 3020, a read-only memory (ROM) 3030, a random access memory (RAM) 3040, a communication port 3050 connected to a network, an input / output component 3060, a hard disk 3070, etc. The storage device in the computing device 3000, such as ROM 3030 or hard disk 3070, may store various data or files used for processing and / or communication of the method provided by the present disclosure and program instructions executed by the CPU. The computing device 3000 may also include a user interface 3080. Of course, Figure 4 The architecture shown is only exemplary and can be omitted according to actual needs when implementing different devices. Figure 4 One or more components of a computing device are shown.

[0086] The embodiment of the present invention also provides a computer-readable storage medium, such as Figure 5 As shown, it is a schematic diagram of a storage medium provided by an embodiment of the present invention, and a computer readable instruction 4010 is stored on the computer storage medium 4020. When the computer readable instruction 4010 is executed by the processor, the method according to the embodiment of the present disclosure described with reference to the above figures can be executed. The computer readable storage medium in the embodiment of the present disclosure can be a volatile memory or a non-volatile memory, or can include both volatile and non-volatile memories. The non-volatile memory can be a read-only memory (ROM), a programmable read-only memory (PROM), an erasable programmable read-only memory (EPROM), an electrically erasable programmable read-only memory (EEPROM) or a flash memory. The volatile memory can be a random access memory (RAM), which is used as an external cache. By way of example and not limitation, many forms of RAM are available, such as static random access memory (SRAM), dynamic random access memory (DRAM), synchronous dynamic random access memory (SDRAM), double data rate synchronous dynamic random access memory (DDRSDRAM), enhanced synchronous dynamic random access memory (ESDRAM), synchronous link dynamic random access memory (SLDRAM), and direct memory bus random access memory (DR RAM). It should be noted that the memory of the methods described herein is intended to include, but is not limited to, these and any other suitable types of memory. It should be noted that the memory of the methods described herein is intended to include, but is not limited to, these and any other suitable types of memory.

[0087] The embodiments of the present disclosure further provide a computer program product or system, including a computer program, which implements the steps of the above method when executed by a processor.

[0088] In some embodiments, this embodiment also discloses a control system for an artificial liver blood purification circuit, such as Figure 2As shown, the system comprises: The acquisition module 201 is used to acquire an instruction to open or close at least one component in the pipeline; the pipeline includes: an input component, a secondary membrane separator, a connecting pipe 2, a connecting pipe 3, a filtration pump P3, and an output component; the input component is connected to the lower end of the secondary membrane separator, the upper end of the secondary membrane separator is connected to the filtration pump P3 through the connecting pipe 2, the secondary membrane separator body is provided with a port 1 and a port 2, and the port 1 is connected to the output component through the connecting pipe 3; the component includes a disconnection interface 1 provided at the connecting pipe 2 and a disconnection interface 2 provided at the connecting pipe 3; The first processing module 202 is used to change the flow direction of the plasma flowing out after passing through the output component according to the instruction; when the disconnect interface 1 and the disconnect interface 2 are opened, the S1 interface located at the disconnect interface 1 is connected with the S6 interface of the disconnect interface 2 to control the plasma passing through the secondary membrane separator to flow into the output component; and the S2 interface located at the disconnect interface 1 is connected with the S5 interface of the disconnect interface 2 to control the plasma passing through the secondary membrane separator to flow out along port 1 and flow into port 2 through the filtration pump P3.

[0089] In some embodiments, the system also includes: a second processing module, used to obtain an instruction to open T-tube one, and control the plasma passing through the secondary membrane separator to flow into the secondary membrane separator along port one in sequence through the S5 interface, S2 interface, filtration pump P3, disconnection interface three, processing device, T-tube one, and port two; after flowing into the secondary membrane separator along port two, it flows from the secondary membrane separator from top to bottom, and flows out along port one on the side of the secondary membrane separator body, and the outflowing liquid flows into the filtration pump P3 through the S5 interface and the S2 interface, forming a self-circulation.

[0090] In some embodiments, the system further includes: a third processing module, which is used to start a second treatment mode when obtaining instructions to close disconnect interface one and disconnect interface two, and instructions to close T-tube one and T-tube two, and to control the plasma passing through the secondary membrane separator to be discharged from the upper end of the secondary membrane separator through connecting tube two, filtration pump P3, and waste liquid tube two in sequence; at the same time, it also controls the plasma passing through the input component to flow directly into the secondary membrane separator through connecting tube one; optionally, the second treatment mode also includes: controlling the plasma flowing out of port one to flow into the output component through connecting tube three.

[0091] In some embodiments, the system also includes: a fourth processing module, which is used to start the third treatment mode when obtaining an instruction to open the disconnect interface one, the multi-port tube, and the T-tube three, and to control the plasma to flow into the multi-port tube, T-tube three, and then into the connecting tube five through the S1 interface of the connecting tube two, and then into the venous pot.

[0092] In some embodiments, the system also includes: a fifth processing module, which is used to start the fourth treatment mode when obtaining an instruction to turn on T-tube 2, and control the plasma after passing through the plasma pot to be discharged as waste plasma through waste liquid pipe 1; optionally, the fourth treatment mode also includes: obtaining a connecting tube between the infusion pot, the return pump P4 and the venous pot in the conductive multi-port tube, and controlling the nutrient solution in the infusion pot to flow into the venous pot after passing through the return pump P4; the speed at which the nutrient solution flows into the venous pot is consistent with the speed at which the waste plasma is discharged.

[0093] In some embodiments, the system further includes: a sixth processing module, which is used to form an S7 interface and an S8 interface on both sides of the disconnect interface four when obtaining an instruction to open the disconnect interface four.

[0094] It should be noted that the flowcharts and block diagrams in the accompanying drawings illustrate the possible architecture, functions and operations of the systems, methods and computer program products according to various embodiments of the present disclosure. In this regard, each box in the flowchart or block diagram can represent a module, a program segment, or a part of a code, and the module, program segment, or a part of the code contains one or more executable instructions for implementing the specified logical function. It should also be noted that in some alternative implementations, the functions marked in the box can also occur in a different order from the order marked in the accompanying drawings. For example, two boxes represented in succession can actually be executed substantially in parallel, and they can sometimes be executed in the opposite order, depending on the functions involved. It should also be noted that each box in the block diagram and / or flowchart, and the combination of boxes in the block diagram and / or flowchart can be implemented with a dedicated hardware-based system that performs a specified function or operation, or can be implemented with a combination of dedicated hardware and computer instructions.

[0095] In general, various example embodiments of the present disclosure may be implemented in hardware or dedicated circuits, software, firmware, logic, or any combination thereof. Certain aspects may be implemented in hardware, while other aspects may be implemented in firmware or software that may be executed by a controller, microprocessor, or other computing device. When various aspects of the disclosed embodiments are illustrated or described as block diagrams, flow charts, or using some other graphical representation, it will be understood that the blocks, devices, systems, techniques, or methods described herein may be implemented in hardware, software, firmware, dedicated circuits or logic, general purpose hardware or controllers or other computing devices, or some combination thereof as non-limiting examples.

[0096] Those skilled in the art can clearly understand that, for the convenience and brevity of description, the specific working processes of the systems, devices and units described above can refer to the corresponding processes in the aforementioned method embodiments and will not be repeated here.

[0097] In the several embodiments provided in the present application, it should be understood that the disclosed systems, devices and methods can be implemented in other ways. For example, the device embodiments described above are only schematic. For example, the division of the units is only a logical function division. There may be other division methods in actual implementation, such as multiple units or components can be combined or integrated into another system, or some features can be ignored or not executed. Another point is that the mutual coupling or direct coupling or communication connection shown or discussed can be an indirect coupling or communication connection through some interfaces, devices or units, which can be electrical, mechanical or other forms.

[0098] The units described as separate components may or may not be physically separated, and the components shown as units may or may not be physical units, that is, they may be located in one place or distributed on multiple network units. Some or all of the units may be selected according to actual needs to achieve the purpose of the solution of this embodiment.

[0099] In addition, each functional unit in each embodiment of the present invention may be integrated into one processing unit, or each unit may exist physically separately, or two or more units may be integrated into one unit. The above-mentioned integrated unit may be implemented in the form of hardware or in the form of software functional units.

[0100] The exemplary embodiments of the present disclosure described in detail above are merely illustrative and not restrictive. It should be understood by those skilled in the art that various modifications and combinations may be made to these embodiments or their features without departing from the principles and spirit of the present disclosure, and such modifications should fall within the scope of the present disclosure.

Claims

1. A control method for an artificial liver blood purification circuit, characterized in that: The method comprises: Obtaining instructions for opening or closing at least one component in a pipeline; the pipeline includes: an input component, a secondary membrane separator, a second connecting pipe, a third connecting pipe, a filtration pump, and an output component; the input component is connected to the lower end of the secondary membrane separator, the upper end of the secondary membrane separator is connected to the filtration pump through the second connecting pipe, the secondary membrane separator body is provided with a port 1 and a port 2, and the port 1 is connected to the output component through the third connecting pipe; the component includes a disconnection interface 1 provided at the second connecting pipe and a disconnection interface 2 provided at the third connecting pipe; The flow direction of the plasma flowing out of the output component is changed according to the instructions; when the disconnect interface 1 and the disconnect interface 2 are opened, the S1 interface located at the disconnect interface 1 is connected with the S6 interface of the disconnect interface 2, so as to control the plasma passing through the secondary membrane separator to flow into the output component; the S2 interface located at the disconnect interface 1 is connected with the S5 interface of the disconnect interface 2, so as to control the plasma passing through the secondary membrane separator to flow out along the port 1 and flow into the port 2 through the filtration pump.

2. The control method of the artificial liver blood purification circuit according to claim 1, characterized in that: The controlling of the plasma passing through the secondary membrane separator to flow into the output component comprises: controlling the plasma passing through the secondary membrane separator to flow into the output component from the upper end of the secondary membrane separator through the S1 interface and the S6 interface in sequence; Optionally, port one is located at a lower end of port two; Optionally, the pipeline also includes: a connecting tube four arranged at port two, a T-tube one arranged at the connecting tube four, a processing device, a waste liquid tube two arranged at the filtration pump P3, and a disconnection interface three is arranged at the waste liquid tube two; opening the disconnection interface one and the disconnection interface two is a first treatment mode, and the first treatment mode also includes: obtaining an instruction to open the T-tube one, controlling the plasma passing through the secondary membrane separator to flow into the secondary membrane separator along port one in sequence through the S5 interface, the S2 interface, the filtration pump P3, the disconnection interface three, the processing device, the T-tube one, and the port two; after flowing into the secondary membrane separator along the port two, it flows from the secondary membrane separator from top to bottom, and flows out along the port one on the side of the secondary membrane separator body, and the liquid after flowing out flows into the filtration pump P3 through the S5 interface and the S2 interface to form a self-circulation; Optionally, the processing device includes any one of the following: a biological device, a non-biological adsorption device, and a perfusion device.

3. The control method of the artificial liver blood purification circuit according to claim 1, characterized in that: The pipeline also includes a connecting pipe 1 arranged at the lower end of the input component and the lower end of the secondary membrane separator, and a waste liquid pipe 1 connected to the connecting pipe 1; the component also includes a T-tube 2 arranged at the connection between the connecting pipe 1 and the waste liquid pipe 1; when the instructions to close the disconnection interface 1 and the disconnection interface 2 and the instructions to close the T-tube 1 and the T-tube 2 are obtained, the second treatment mode is turned on, and the plasma passing through the secondary membrane separator is controlled to be discharged from the upper end of the secondary membrane separator through the connecting pipe 2, the filtration pump P3, and the waste liquid pipe 2 in sequence; at the same time, the plasma passing through the input component is also controlled to flow directly into the secondary membrane separator through the connecting pipe 1; Optionally, the second treatment mode also includes: controlling the plasma flowing out of port one to flow into the output component through connecting tube three.

4. The control method of the artificial liver blood purification circuit according to claim 1, characterized in that: The pipeline also includes: a fluid infusion pot; the output component includes a return plasma pump P4, a venous pot, and an outlet venous tube; the input component includes: a primary membrane separator and a plasma pot; the lower end of the primary membrane separator is sequentially connected to the venous pot and the first end of the outlet venous tube through a connecting pipe; the fluid infusion pot, the return plasma pump P4 and the venous pot are sequentially connected through a connecting pipe; the lower end of the plasma pot is connected to the lower end of the secondary membrane separator through a connecting pipe 1, and the port 1 of the secondary membrane separator is sequentially connected to the venous pot through a connecting pipe 2, the return plasma pump P4 and a connecting pipe 5; Optionally, the component further comprises a multi-port tube arranged at the connecting tube three and a T-tube three arranged at the connecting tube five; when an instruction to start the disconnection interface one, the multi-port tube and the T-tube three is obtained, the third treatment mode is started, and the plasma is controlled to flow into the multi-port tube, the T-tube three, the connecting tube five, and then into the venous pot in sequence through the S1 interface of the connecting tube two; Optionally, the multi-port tube has at least five ports, the first port is used to connect to the S1 interface at the connecting tube 2, the second port is used to connect to the port 1 of the secondary membrane separator, the third port is used to connect to the T-tube 3, the fourth port is used to connect to the liquid replenishment pot, and the fifth port is used to connect to the return slurry pump.

5. The control method of the artificial liver blood purification circuit according to claim 1, characterized in that: When the instruction to start the second T-tube is obtained, the fourth treatment mode is started, and the plasma after the plasma passes through the plasma pot is controlled to be discharged as waste plasma through the waste liquid pipe one; Optionally, the fourth treatment mode also includes: obtaining a connecting tube between the fluid infusion pot, the slurry pump P4 and the venous pot in the conductive multi-port tube, and controlling the nutrient solution in the fluid infusion pot to flow into the venous pot after passing through the slurry pump P4; the speed at which the nutrient solution flows into the venous pot is consistent with the speed at which the waste plasma is discharged; the nutrient solution is a supplementary solution / replacement solution, and the nutrient solution includes one or more of the following: plasma, albumin solution, colloid solution, plasma bag supplies, and balancing solution.

6. The control method of the artificial liver blood purification circuit according to claim 1, characterized in that: The component also includes a disconnection interface 4 arranged between the T-shaped tube 3 of the connecting tube 5 and the venous pot; when an instruction to open the disconnection interface 4 is obtained, an S7 interface and an S8 interface are formed on both sides of the disconnection interface 4; Optionally, the input component also includes: an inlet arterial tube, a blood pump P1, an arterial pot, a primary membrane separator, and a plasma pump P2; the output component also includes an outlet venous tube; the first end of the inlet arterial tube is connected to the patient, the second end of the inlet arterial tube is sequentially connected to the blood pump P1, the arterial pot, and the upper end of the primary membrane separator through a connecting tube, the body side port 2 of the primary membrane separator is sequentially connected to the plasma pump P2 and the upper end of the plasma pot through a connecting tube; the return plasma pump P4 is connected to the first end of the outlet venous tube, and the second end of the outlet venous tube is connected to the patient.

7. The control method of the artificial liver blood purification circuit according to claim 1, characterized in that: Different treatment modes correspond to different types of treatment equipment, and the types of treatment equipment include any of the following: PE treatment equipment, DPMAS treatment equipment, DFPP treatment equipment, and new secondary adsorption treatment equipment; Optionally, the first treatment mode is a treatment mode when a new type of secondary adsorption treatment equipment is used; Optionally, the second treatment mode is a treatment mode when a DFPP treatment device is used; Optionally, the third treatment mode is a treatment mode when a DPMAS treatment device is used; Optionally, the fourth treatment mode is a treatment mode when a PE treatment device is used; Optionally, the disconnected end interfaces at both ends of the disconnecting interface are respectively provided with stop valves or stop clamps.

8. A computer device, characterized in that: The device comprises: a memory and a processor; the memory is used to store a computer program; the processor executes the computer program to implement the steps of the method according to any one of claims 1 to 7.

9. A computer-readable storage medium, characterized in that: A computer program is stored thereon, and when the computer program is executed by a processor, the steps of the method according to any one of claims 1 to 7 are implemented.

10. A computer program product, comprising a computer program, characterized in that When the computer program is executed by a processor, the steps of the method described in any one of claims 1 to 7 are implemented.

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