Sample analyzer

Abstract

The invention relates to a sample analyzer. An ultrasonic device in the sample analysis device acts on the target liquid to uniformly mix the target liquid, and the control device drives the ultrasonic device to perform ultrasonic uniform mixing on the target liquid by adopting the first driving parameter and the second driving parameter in sequence, when the first driving parameter is adopted to drive the ultrasonic device to carry out ultrasonic uniform mixing on the target liquid, the working parameter of the ultrasonic device meets the preset condition, and the second driving parameter is smaller than the first driving parameter. The ultrasonic device is driven by adopting the first driving parameter and the second driving parameter in sequence, the ultrasonic device can be prevented from working under the condition of large driving parameter driving all the time, and the service life of the ultrasonic device can be prolonged.

Description

Technical Field

[0001] The present application relates to the technical field of medical devices, and in particular to a sample analysis device. Background Art

[0002] In the field of sample analysis, target liquids such as samples, reagents, or mixtures of samples and reagents need to be mixed for detection. In the scheme of using ultrasound to mix the target liquid, constant driving parameters are generally used on the ultrasonic device. The ultrasonic driving parameters required for different target liquids to achieve the expected target liquid state in the same time will vary due to the type of target liquid and the environment in which it is located. In order to ensure the mixing effect, the driving parameters of the ultrasonic device generally need to increase some margin. However, the increase in margin will cause the ultrasonic device to continue to work under larger driving parameters, which will affect the service life of the ultrasonic device. Summary of the invention

[0003] In view of this, the embodiments of the present application hope to provide a sample analysis device, aiming to solve the technical problem in the related art that the ultrasonic device is driven to work continuously with larger driving parameters, resulting in a shortened service life of the ultrasonic device.

[0004] To achieve the above objectives, the present application provides a sample analysis device in a first aspect, comprising:

[0005] A sample dispensing mechanism, used to dispense at least part of the sample in the sample container into the reaction container;

[0006] A reagent dispensing mechanism, used to dispense at least part of the reagent in the reagent container into the reaction container;

[0007] A measuring component for measuring a reaction solution made of at least a sample and a mixed solution of a reagent;

[0008] an ultrasonic device, used for ultrasonically mixing a target liquid, wherein the target liquid includes at least one of the sample, the reagent and the mixed liquid;

[0009] A control device, the control device being configured to: sequentially use a first driving parameter and a second driving parameter to drive the ultrasonic device to ultrasonically mix the target liquid, wherein the working parameters of the ultrasonic device in the process of using the first driving parameter to drive the ultrasonic device to ultrasonically mix the target liquid meet a preset condition;

[0010] Wherein, the second driving parameter is smaller than the first driving parameter.

[0011] In some embodiments, the control device is further configured to: control the start-up of the ultrasonic device with a first preset driving parameter, and determine whether the working parameters of the ultrasonic device meet the preset conditions; if yes, drive the ultrasonic device with a second driving parameter; if not, increase the driving parameters of the ultrasonic device, and execute the step of determining whether the working parameters of the ultrasonic device meet the preset conditions until the driving parameters of the ultrasonic device are greater than or equal to the second preset driving parameters. When the working parameters of the ultrasonic device meet the preset conditions, the driving parameters of the ultrasonic device are the first driving parameters.

[0012] In some embodiments, the control device is further configured to generate an alarm signal when the driving parameter of the ultrasonic device is greater than or equal to the second preset driving parameter.

[0013] In some embodiments, the working parameter satisfies a preset condition, including: the working parameter reaches a first preset value, and when the working parameter reaches the first preset value, it indicates that cavitation occurs in the target liquid.

[0014] In some embodiments, the operating parameters of the ultrasonic device include one of the load impedance, driving voltage, driving current, and driving power of the ultrasonic device.

[0015] In some embodiments, the first driving parameter and the second driving parameter include a driving voltage, and the operating parameter of the ultrasonic device includes one of a load impedance, a driving current, and a driving power of the ultrasonic device; or

[0016] The first driving parameter and the second driving parameter include driving current, and the working parameter of the ultrasonic device includes one of load impedance, driving voltage, and driving power of the ultrasonic device; or,

[0017] The first driving parameter and the second driving parameter include driving power, and the working parameter of the ultrasonic device includes one of load impedance, driving voltage, and driving current of the ultrasonic device.

[0018] In some embodiments, the ultrasonic device includes an ultrasonic transducer and an ultrasonic vibrator, wherein the ultrasonic transducer is used to connect to the ultrasonic vibrator and drive the ultrasonic vibrator to vibrate, and the ultrasonic vibrator is used to be inserted into the target liquid to ultrasonically mix the target liquid.

[0019] A second aspect of the present application provides a sample analysis device, comprising:

[0020] A sample dispensing mechanism, used to dispense at least part of the sample in the sample container into the reaction container;

[0021] A reagent dispensing mechanism, used to dispense at least part of the reagent in the reagent container into the reaction container;

[0022] A measuring component for measuring a reaction solution made of at least a sample and a mixed solution of a reagent;

[0023] an ultrasonic device, used for ultrasonically mixing a target liquid, wherein the target liquid includes at least one of the sample, the reagent and the mixed liquid;

[0024] A control device, wherein the control device is configured to: sequentially use a first driving parameter and a second driving parameter to drive the ultrasonic device to ultrasonically mix the target liquid, and cavitation occurs in the target liquid during the process of using the first driving parameter to drive the ultrasonic device to ultrasonically mix the target liquid; wherein the second driving parameter is smaller than the first driving parameter.

[0025] In some embodiments, the control device is further configured to: control the start-up of the ultrasonic device with a first preset driving parameter, determine whether the working parameter fed back by the ultrasonic device meets a preset condition, and if so, determine that cavitation occurs in the target liquid and use a second driving parameter to drive the ultrasonic device; if not, execute the step of determining whether the working parameter fed back by the ultrasonic device meets the preset condition, increase the driving parameter of the ultrasonic device, and execute the step of determining whether the working parameter fed back by the ultrasonic device meets the preset condition until the driving parameter of the ultrasonic device is greater than or equal to the second preset driving parameter. When the working parameter of the ultrasonic device meets the preset condition, the driving parameter of the ultrasonic device is the first driving parameter.

[0026] In some embodiments, the control device is further configured to generate an alarm signal when the driving parameter of the ultrasonic device is greater than or equal to the second preset driving parameter.

[0027] In some embodiments, the sample analysis device further comprises an acoustic transducer, and the acoustic transducer is used to monitor the sound signal of the target liquid. The control device is configured to: determine whether cavitation occurs in the target liquid according to feedback information from the acoustic transducer; or,

[0028] The sample analysis device further comprises a visual monitoring device, which is used to monitor the image signal of the target liquid. The control device is configured to determine whether cavitation occurs in the target liquid according to feedback information from the visual monitoring device.

[0029] A third aspect of the present application provides a sample analysis device, comprising:

[0030] A sample dispensing mechanism, including a sample dispensing needle, for dispensing at least part of the sample in the sample container into the reaction container;

[0031] A reagent dispensing mechanism, including a reagent dispensing needle, for dispensing at least part of the reagent in the reagent container into the reaction container;

[0032] A measuring component for measuring a reaction solution made of at least a sample and a mixed solution of a reagent;

[0033] a cleaning liquid supply device, the cleaning liquid supply device being used to supply cleaning liquid to clean at least one of the sample dispensing needle, the reagent dispensing needle, the reaction container, and the stirring rod;

[0034] an ultrasonic device for transmitting ultrasonic waves to a target liquid, wherein the target liquid includes the sample, the reagent, a mixed liquid containing at least the sample and the reagent, and one of the cleaning liquid;

[0035] A control device, wherein the control device is configured to: sequentially use a first driving parameter and a second driving parameter to drive the ultrasonic device to transmit ultrasonic waves to the target liquid, and an operating parameter of the ultrasonic device in the process of using the first driving parameter to drive the ultrasonic device to transmit ultrasonic waves to the target liquid satisfies a preset condition;

[0036] Wherein, the second driving parameter is smaller than the first driving parameter.

[0037] In some embodiments, the control device is further configured to: control the start-up of the ultrasonic device with a first preset driving parameter, and determine whether the working parameters of the ultrasonic device meet the preset conditions; if yes, drive the ultrasonic device with a second driving parameter; if not, increase the driving parameters of the ultrasonic device, and execute the step of determining whether the working parameters of the ultrasonic device meet the preset conditions until the driving parameters of the ultrasonic device are greater than or equal to the second preset driving parameters. When the working parameters of the ultrasonic device meet the preset conditions, the driving parameters of the ultrasonic device are the first driving parameters.

[0038] In some embodiments, the operating parameters of the ultrasonic device include one of the load impedance, driving voltage, driving current, and driving power of the ultrasonic device.

[0039] In the sample analysis device provided in the present application, the ultrasonic device is driven to work by sequentially using two driving parameters of different sizes, namely a first driving parameter and a second driving parameter. After the preset conditions of the required mixing effect are met during the operation with a large driving parameter, since it is not necessary to always work under the condition of a high driving parameter to maintain the required mixing effect, a small driving parameter is used to keep the ultrasonic device working, so that the ultrasonic device does not need to continue to work under the condition of a high driving parameter during the process of mixing the target liquid, which is beneficial to extending the service life of the ultrasonic device. BRIEF DESCRIPTION OF THE DRAWINGS

[0040] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the structures shown in these drawings without paying creative work.

[0041] Figure 1 is a schematic diagram of a sample analysis device in an embodiment;

[0042] Figure 2 Schematic diagram of an ultrasonic device in an embodiment.

[0043] Explanation of the accompanying figures: sample loading mechanism 11, sample dispensing mechanism 12, reagent loading mechanism 13, reagent dispensing mechanism 14, reaction mechanism 15, magnetic separation and cleaning mechanism 16, ultrasonic device 17, base 171, ultrasonic transducer 172, ultrasonic vibrator 173, measuring component 18, cleaning liquid supply device 19. DETAILED DESCRIPTION

[0044] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0045] It should be noted that all directional indications in the embodiments of the present invention (such as up, down, left, right, front, back, etc.) are only used to explain the relative position relationship, movement status, etc. between the components in a certain specific posture. If the specific posture changes, the directional indication will also change accordingly.

[0046] It should also be noted that when an element is referred to as being "fixed on" or "disposed on" another element, it may be directly on the other element or there may be an intermediate element at the same time. When an element is referred to as being "connected to" another element, it may be directly connected to the other element or may be indirectly connected to the other element through an intermediate element.

[0047] In addition, the descriptions of "first", "second", etc. in the present invention are only used for descriptive purposes and cannot be understood as indicating or implying their relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In addition, the technical solutions between the various embodiments can be combined with each other, but they must be based on the ability of ordinary technicians in the field to implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be deemed that such a combination of technical solutions does not exist and is not within the scope of protection required by the present invention.

[0048] The present application provides a sample analysis device, which is described in detail below.

[0049] Please refer to Figure 1 and Figure 2 , Figure 1 is a schematic diagram of a sample analysis device in an embodiment, Figure 2 FIG. 1 is a schematic diagram of an ultrasonic device 17 in an embodiment.

[0050] It is understandable that the sample analysis device may be a blood cell analyzer, a biochemical analyzer, a chemical immunoassay analyzer, etc., and is not limited here. Next, a chemical immunoassay analyzer is used as an example for description.

[0051] Please refer to Figure 1 The chemical immunoassay analyzer includes a sample loading mechanism 11, a sample dispensing mechanism 12, a reagent loading mechanism 13, a reagent dispensing mechanism 14, a reaction mechanism 15, a magnetic separation and cleaning mechanism 16, an ultrasonic device 17, a measuring component 18, a cleaning liquid supply device 19, and a control device (not shown in the figure).

[0052] The sample loading mechanism 11 is used to load the sample carrying component, which can be a sample container or a sample rack for accommodating multiple sample containers, which is not limited here. The sample container is used to accommodate the sample. The sample loading mechanism 11 can be manual injection or automatic injection, which is not limited here.

[0053] The sample dispensing mechanism 12 is used to dispense at least a portion of the sample in the sample container into the reaction container. In some embodiments, the sample dispensing mechanism 12 includes a sample dispensing needle.

[0054] The reagent loading mechanism 13 is used to load the reagents required for sample analysis. In one embodiment, the reagent loading mechanism 13 can be a reagent disk, which is a disc-shaped structure with multiple positions for carrying reagent containers. The reagent loading mechanism 13 can rotate and drive the reagent container it carries to rotate, and is used to rotate the reagent container to a specific position. The number of reagent loading mechanisms 13 can be one or more.

[0055] The reagent dispensing mechanism 14 is used to dispense at least part of the reagent in the reagent container into the reaction container. In some embodiments, the reagent dispensing mechanism 14 includes a reagent dispensing needle.

[0056] The reaction mechanism 15 is used to carry the reaction container. In some examples, the reaction mechanism 15 includes a carrying position for carrying the reaction container, a heat preservation device and a rotating device. The heat preservation device includes a heating element for maintaining the temperature in the reaction mechanism 15. The rotating device is used to transfer the reaction container between various stations.

[0057] The magnetic separation and cleaning mechanism 16 is used to perform magnetic separation treatment on the mixed solution containing at least the magnetic bead reagent in the reaction container. In some embodiments, the magnetic separation and cleaning mechanism 16 is provided with a magnetic separation and cleaning station on the reaction mechanism 15, which is used to treat the mixed solution containing at least the magnetic bead reagent in the reaction container located at the magnetic separation and cleaning station.

[0058] The ultrasonic device 17 is used to generate ultrasonic waves. In some embodiments, the ultrasonic device 17 includes a base 171, an ultrasonic transducer 172 and an ultrasonic vibrator 173. The base 171 is connected to the ultrasonic transducer 172. The ultrasonic transducer 172 includes a backing layer, a piezoelectric layer and a matching layer connected in sequence. The piezoelectric layer is a piezoelectric crystal. The piezoelectric crystal generates compression and expansion in the thickness direction through the inverse piezoelectric effect under the action of the driving electrical signal. The frequency of this deformation reaches the ultrasonic frequency, forming ultrasonic vibration. The ultrasonic transducer 172 is used to connect to the ultrasonic vibrator 173 and drive the ultrasonic vibrator 173 to vibrate.

[0059] The measuring unit 18 is used to measure a reaction solution composed of at least a mixed solution of a reagent and a sample.

[0060] The cleaning liquid supply device 19 is used to supply cleaning liquid to clean at least one of the sample dispensing needle, the reagent dispensing needle, the reaction container, and the stirring rod. In some embodiments, when the ultrasonic device 17 is used for ultrasonic cleaning, there can be multiple ultrasonic devices 17, which are used to ultrasonically clean the sample dispensing needle, the reagent dispensing needle, the reaction container, and the stirring rod. In some embodiments, the stirring rod is used to stir the mixed solution including at least the sample and the reagent so that the mixed solution is fully mixed.

[0061] As an embodiment, when the ultrasonic device 17 is used to clean the sample dispensing needle, the sample analysis device further includes a first cleaning pool, and the cleaning liquid supply device is used to supply cleaning liquid to the first cleaning pool to clean the sample dispensing needle.

[0062] As an embodiment, when the ultrasonic device 17 is used to clean the reagent dispensing needle, the sample analysis device further includes a second cleaning pool, and the cleaning liquid supply device is used to supply cleaning liquid to the second cleaning pool to clean the reagent dispensing needle.

[0063] As an embodiment, when the ultrasonic device 17 is used to clean the stirring rod, the stirring rod is used to stir the sample or reagent or the mixture of the sample and the reagent in the reaction container. The sample analysis device also includes a third cleaning tank, and the cleaning liquid supply device is used to supply cleaning liquid to the third cleaning tank to clean the stirring rod.

[0064] As an embodiment, when the ultrasonic device 17 is used to clean the reaction container, the cleaning liquid supply device is used to supply cleaning liquid to the reaction container to clean the reaction container.

[0065] The control device is used to control the actions of various components of the chemical immunoassay analyzer according to preset instructions or instructions input by the operator, so that the immunoassay analyzer can complete the measurement of the sample.

[0066] In the process of measuring samples by immunoassay analyzer, it is necessary to mix the samples, reagents or at least the mixture of samples and reagents. Common mixing methods include stirring rod stirring, vortex mixing, oscillation mixing, ultrasonic mixing, etc. In the scheme of ultrasonic mixing, an ultrasonic device is used to radiate ultrasonic waves to the target liquid such as the sample, reagent or at least the mixture of the sample and reagent to cause cavitation of the target liquid, and the cavitation effect is used to achieve the mixing of the target liquid. The common design scheme for ultrasonic mixing is to use constant driving parameters to act on the ultrasonic device to generate corresponding ultrasonic waves. Due to the constant driving parameters, the ultrasonic sound pressure required to achieve cavitation within the same time limit is different when facing different types of liquids or the same type of liquid in different environments. In order to ensure the success rate of cavitation, the driving parameters of the ultrasonic device generally need to increase some margin. Larger driving parameters will accelerate the use loss of the transducer, which is not conducive to the design of systems with long life requirements.

[0067] Based on the principle of liquid medium cavitation, that is, the difficulty of liquid medium cavitation under ultrasound is affected by the cavitation nuclei (micro bubbles, impurities, etc.) in the liquid medium. The smaller the cavitation nuclei in the liquid, the higher the ultrasound intensity required to cause cavitation. After cavitation is achieved, the number of cavitation nuclei in the liquid medium increases, and the ultrasound intensity required to maintain cavitation decreases. Based on this, the cavitation characteristic of low ultrasound intensity required to maintain cavitation is used to extend the service life of the ultrasonic device without affecting the mixing effect.

[0068] In some embodiments, the ultrasonic device 17 is used to ultrasonically mix the target liquid, and the target liquid includes at least one of a sample, a reagent, and a mixed liquid. The control device is configured to: sequentially use the first driving parameter and the second driving parameter to drive the ultrasonic device 17 to ultrasonically mix the target liquid, and the working parameters of the ultrasonic device 17 in the process of using the first driving parameter to drive the ultrasonic device 17 to ultrasonically mix the target liquid meet the preset conditions; wherein the second driving parameter is less than the first driving parameter. The second driving parameter is a parameter to ensure the mixing effect, and the second driving parameter can be adjusted according to the desired mixing effect and time requirements.

[0069] In this embodiment, a large first driving parameter is first used to drive the ultrasonic device 17 so that the working parameters of the ultrasonic device 17 meet the preset conditions, and then a small second driving parameter is used to drive the ultrasonic device 17. In this way, the ultrasonic device 17 can continue to work under a smaller ultrasonic action intensity, which is beneficial to extending the service life of the ultrasonic device 17.

[0070] In some embodiments, the second driving parameter is a constant value. During ultrasonic mixing, in order to make the timing of the entire machine more controllable, it is necessary to ensure that the time spent on mixing for different tests is basically consistent. Therefore, setting a constant value is helpful to ensure the mixing effect. The constant value depends on the expectation of the mixing effect at a specific time.

[0071] In some embodiments, the control device controls the ultrasonic device 17 to start with a first preset driving parameter, and determines whether the working parameters of the ultrasonic device 17 meet the preset conditions. If so, the second driving parameters are used to drive the ultrasonic device 17. If not, the driving parameters of the ultrasonic device 17 are increased, and the step of determining whether the working parameters of the ultrasonic device 17 meet the preset conditions is performed until the driving parameters of the ultrasonic device 17 are greater than or equal to the second preset driving parameters. When the working parameters of the ultrasonic device 17 meet the preset conditions, the driving parameters of the ultrasonic device 17 are the first driving parameters.

[0072] By judging whether the working parameters meet the preset conditions during the process of increasing the driving parameters, the driving parameters of the ultrasonic parameters are switched in time, thereby reducing the consumption of the ultrasonic device working under unnecessary large driving parameters.

[0073] In other embodiments, the control device controls the ultrasonic device 17 to start with a first preset driving parameter, increases the first preset driving parameter to a third preset driving parameter, the third preset driving parameter being that under the driving parameter condition, the working parameter of the ultrasonic device 17 generally does not meet the preset condition, continues to increase the driving parameter, and after the driving parameter is greater than the third preset driving parameter, determines whether the working parameter of the ultrasonic device 17 meets the preset condition; if so, uses the second driving parameter to drive the ultrasonic device 17; if not, increases the driving parameter of the ultrasonic device 17, and executes the step of determining whether the working parameter of the ultrasonic device 17 meets the preset condition until the driving parameter of the ultrasonic device 17 is greater than or equal to the second preset driving parameter; when the working parameter of the ultrasonic device 17 meets the preset condition, the driving parameter of the ultrasonic device 17 is the first driving parameter.

[0074] After the ultrasonic device is started and increases to a certain range of driving parameters, the working parameters of the ultrasonic device generally do not meet the preset conditions. During this time period, the control device does not determine whether the working parameters of the ultrasonic device meet the preset conditions, which is beneficial to saving the computing resources of the control device.

[0075] In some embodiments, the control device is configured to generate an alarm signal when the driving parameter of the ultrasonic device 17 is greater than or equal to the second preset driving parameter, which is conducive to the operator to timely analyze the reasons why the working parameters fail to meet the preset conditions and handle the fault in time. In some examples, the immunoassay analyzer also includes a sound generating device, and the alarm signal triggers the sound generating device to generate a sound alarm.

[0076] In some embodiments, the working parameter satisfies a preset condition, including: the working parameter reaches a first preset value, and when the working parameter reaches the first preset value, it indicates that cavitation occurs in the target liquid.

[0077] In some embodiments, the working parameters of the ultrasonic device 17 include one of the load impedance, driving voltage, driving current, and driving power of the ultrasonic device 17. When the target liquid meets the mixing requirements, the load impedance, driving voltage, driving current, and driving power of the ultrasonic device will change. By detecting the changes in the working parameters, it is determined whether the state of the target liquid meets the requirements, thereby determining whether to switch the driving parameters.

[0078] The first driving parameter and the second driving parameter include a driving voltage, and the working parameter of the ultrasonic device 17 includes one of a load impedance, a driving current, and a driving power of the ultrasonic device 17; or,

[0079] The first driving parameter and the second driving parameter include a driving current, and the working parameter of the ultrasonic device 17 includes one of a load impedance, a driving voltage, and a driving power of the ultrasonic device 17; or,

[0080] The first driving parameter and the second driving parameter include driving power, and the working parameter of the ultrasonic device 17 includes one of load impedance, driving voltage, and driving current of the ultrasonic device 17 .

[0081] In some embodiments, the ultrasonic vibrator is inserted into the target liquid to perform ultrasonic mixing on the target liquid. Compared with the non-contact ultrasonic mixing device, inserting the ultrasonic vibrator directly into the target liquid can reduce the interference of other components on the ultrasonic transmission, so that the ultrasonic mixing effect is better.

[0082] In some embodiments, the ultrasonic device 17 is used to ultrasonically mix the target liquid, and the target liquid includes at least one of a sample, a reagent, and a mixed liquid. The control device is configured to: sequentially use the first driving parameter and the second driving parameter to drive the ultrasonic device 17 to ultrasonically mix the target liquid, and cavitation occurs in the target liquid during the process of using the first driving parameter to drive the ultrasonic device 17 to ultrasonically mix the target liquid; wherein the second driving parameter is less than the first driving parameter.

[0083] The ultrasonic device 17 continuously works at a relatively low ultrasonic intensity, which is beneficial to prolonging the service life of the ultrasonic device 17 compared with the ultrasonic device 17 in the prior art that always operates at a relatively high driving parameter.

[0084] In some embodiments, the control device is configured to: control the start-up of the ultrasonic device 17 with a first preset driving parameter, determine whether the working parameter fed back by the ultrasonic device 17 meets the preset conditions, and if so, determine that cavitation occurs in the target liquid and use the second driving parameter to drive the ultrasonic device 17; if not, execute the step of determining whether the working parameter fed back by the ultrasonic device 17 meets the preset conditions, increase the driving parameter of the ultrasonic device 17, and execute the step of determining whether the working parameter fed back by the ultrasonic device 17 meets the preset conditions until the driving parameter of the ultrasonic device 17 is greater than or equal to the second preset driving parameter. When the working parameter of the ultrasonic device 17 meets the preset conditions, the driving parameter of the ultrasonic device 17 is the first driving parameter.

[0085] By judging whether the working parameters meet the preset conditions during the process of increasing the driving parameters, the driving parameters of the ultrasonic parameters are switched in time, thereby reducing the consumption of the ultrasonic device working under unnecessary large driving parameters.

[0086] In some embodiments, the control device is configured to generate an alarm signal when the driving parameter of the ultrasonic device 17 is greater than or equal to the second preset driving parameter, which is conducive to the operator to timely analyze the reasons why the working parameters fail to meet the preset conditions and handle the fault in time. In some examples, the immunoassay analyzer also includes a sound generating device, and the alarm signal triggers the sound generating device to generate a sound alarm.

[0087] In some embodiments, the chemical immunoassay analyzer further includes a hydroacoustic transducer, which can be used to detect the sound signal of the target liquid, and use the feedback information of the hydroacoustic transducer to determine whether cavitation occurs in the target liquid.

[0088] In some embodiments, the chemical immunoassay analyzer further includes a visual monitoring device, which can be used to measure an image signal of the target liquid and determine whether cavitation occurs in the target liquid based on feedback information from the visual monitoring device.

[0089] In some embodiments, the ultrasonic device 17 is used to transmit ultrasonic waves to a target liquid, and the target liquid includes a sample, a reagent, a mixed liquid containing at least the sample and the reagent, and a cleaning liquid; the control device is configured to: sequentially use a first driving parameter and a second driving parameter to drive the ultrasonic device 17 to transmit ultrasonic waves to the target liquid, and the working parameters of the ultrasonic device 17 in the process of using the first driving parameter to drive the ultrasonic device 17 to transmit ultrasonic waves to the target liquid meet preset conditions; wherein the second driving parameter is less than the first driving parameter.

[0090] By using a large first driving parameter to drive the ultrasonic device 17, the working parameters of the ultrasonic device 17 meet the preset conditions. When a small second driving parameter is used to drive the ultrasonic device 17, the ultrasonic device 17 can work under a smaller ultrasonic action intensity, which is beneficial to extending the service life of the ultrasonic device 17.

[0091] In some embodiments, the control device is further configured to: control the start-up of the ultrasonic device 17 with a first preset driving parameter, and determine whether the working parameters of the ultrasonic device 17 meet the preset conditions; if yes, drive the ultrasonic device 17 with a second driving parameter; if not, increase the driving parameters of the ultrasonic device 17, and execute the step of determining whether the working parameters of the ultrasonic device 17 meet the preset conditions until the driving parameters of the ultrasonic device 17 are greater than or equal to the second preset driving parameters.

[0092] By judging whether the working parameters meet the preset conditions during the process of increasing the driving parameters, the driving parameters of the ultrasonic parameters are switched in time, thereby reducing the consumption of the ultrasonic device working under unnecessary large driving parameters.

[0093] In some embodiments, the working parameters of the ultrasonic device 17 include one of the load impedance, driving voltage, driving current, and driving power of the ultrasonic device 17. When the target liquid meets the mixing requirements, the load impedance, driving voltage, driving current, and driving power of the ultrasonic device will change. By detecting the changes in the working parameters, it is determined whether the state of the target liquid meets the requirements, thereby determining whether to switch the driving parameters.

[0094] The measurement process of a measurement item in the immunoassay analyzer includes: adding a sample and a reagent to form a first mixed solution, mixing and incubating the first mixed solution to obtain a second mixed solution, magnetically separating the second mixed solution to obtain a magnetically separated liquid, adding a substrate to the magnetically separated liquid to obtain a third mixed solution, mixing and incubating the third mixed solution to obtain a reaction solution, and optically measuring the reaction solution. During the magnetic separation process, operations of adding separation liquid and mixing will be performed. The above-mentioned mixed solution as the target liquid includes at least one of the following situations: the first mixed solution after adding a sample and a reagent and before incubation, the second mixed solution during the magnetic separation process, and the third mixed solution formed after the magnetic separation and the addition of the substrate and before incubation.

Claims

1. A sample analysis device, characterized in that: include: A sample dispensing mechanism, used to dispense at least part of the sample in the sample container into the reaction container; A reagent dispensing mechanism, used to dispense at least part of the reagent in the reagent container into the reaction container; A measuring component for measuring a reaction solution made of at least a mixture of a sample and a reagent; an ultrasonic device, used for ultrasonically mixing a target liquid, wherein the target liquid includes at least one of the sample, the reagent and the mixed liquid; A control device, the control device being configured to: sequentially use a first driving parameter and a second driving parameter to drive the ultrasonic device to ultrasonically mix the target liquid, wherein the working parameters of the ultrasonic device in the process of using the first driving parameter to drive the ultrasonic device to ultrasonically mix the target liquid meet a preset condition; Wherein, the second driving parameter is smaller than the first driving parameter.

2. The sample analysis device according to claim 1, wherein: The control device is further configured to: control the ultrasonic device to start up with a first preset driving parameter, determine whether the working parameter of the ultrasonic device meets a preset condition; if so, drive the ultrasonic device with a second driving parameter; If not, increase the driving parameters of the ultrasonic device and execute the step of determining whether the working parameters of the ultrasonic device meet the preset conditions until the driving parameters of the ultrasonic device are greater than or equal to the second preset driving parameters. When the working parameters of the ultrasonic device meet the preset conditions, the driving parameters of the ultrasonic device are the first driving parameters.

3. The sample analysis device according to claim 2, wherein: The control device is further configured to generate an alarm signal when the driving parameter of the ultrasonic device is greater than or equal to the second preset driving parameter.

4. The sample analysis device according to claim 1, wherein: The working parameter meeting a preset condition includes: the working parameter reaching a first preset value, and when the working parameter reaches the first preset value, it indicates that cavitation occurs in the target liquid.

5. The sample analysis device according to any one of claims 1 to 4, characterized in that: The working parameters of the ultrasonic device include one of the load impedance, driving voltage, driving current, and driving power of the ultrasonic device.

6. The sample analysis device according to any one of claims 1 to 4, characterized in that: The first driving parameter and the second driving parameter include a driving voltage, and the working parameter of the ultrasonic device includes one of a load impedance, a driving current, and a driving power of the ultrasonic device; or, The first driving parameter and the second driving parameter include driving current, and the working parameter of the ultrasonic device includes one of load impedance, driving voltage, and driving power of the ultrasonic device; or, The first driving parameter and the second driving parameter include driving power, and the working parameter of the ultrasonic device includes one of load impedance, driving voltage, and driving current of the ultrasonic device.

7. The sample analysis device according to any one of claims 1 to 4, characterized in that: The ultrasonic device comprises an ultrasonic transducer and an ultrasonic vibrator. The ultrasonic transducer is used to connect with the ultrasonic vibrator and drive the ultrasonic vibrator to vibrate. The ultrasonic vibrator is used to be inserted into the target liquid to ultrasonically mix the target liquid.

8. A sample analysis device, characterized in that: include: A sample dispensing mechanism, used to dispense at least part of the sample in the sample container into the reaction container; A reagent dispensing mechanism, used to dispense at least part of the reagent in the reagent container into the reaction container; A measuring component for measuring a reaction solution made of at least a mixture of a sample and a reagent; an ultrasonic device, used for ultrasonically mixing a target liquid, wherein the target liquid includes at least one of the sample, the reagent and the mixed liquid; A control device, wherein the control device is configured to: sequentially use a first driving parameter and a second driving parameter to drive the ultrasonic device to ultrasonically mix the target liquid, and cavitation occurs in the target liquid during the process of using the first driving parameter to drive the ultrasonic device to ultrasonically mix the target liquid; wherein the second driving parameter is smaller than the first driving parameter.

9. The sample analysis device according to claim 8, wherein: The control device is further configured to: control the ultrasonic device to start with a first preset driving parameter, determine whether the working parameter fed back by the ultrasonic device meets a preset condition, and if so, determine that cavitation occurs in the target liquid and drive the ultrasonic device with a second driving parameter; If not, execute the step of determining whether the working parameters fed back by the ultrasonic device meet the preset conditions, increase the driving parameters of the ultrasonic device, and execute the step of determining whether the working parameters fed back by the ultrasonic device meet the preset conditions until the driving parameters of the ultrasonic device are greater than or equal to the second preset driving parameters. When the working parameters of the ultrasonic device meet the preset conditions, the driving parameters of the ultrasonic device are the first driving parameters.

10. The sample analysis device according to claim 9, wherein: The control device is further configured to generate an alarm signal when the driving parameter of the ultrasonic device is greater than or equal to the second preset driving parameter.

11. The sample analysis device according to any one of claims 8 to 10, characterized in that: The sample analysis device further includes an underwater acoustic transducer, which is used to monitor the sound signal of the target liquid. The control device is configured to: determine whether cavitation occurs in the target liquid according to feedback information from the underwater acoustic transducer; or, The sample analysis device further comprises a visual monitoring device, which is used to monitor the image signal of the target liquid. The control device is configured to determine whether cavitation occurs in the target liquid according to feedback information from the visual monitoring device.

12. A sample analysis device, characterized in that: include: A sample dispensing mechanism, including a sample dispensing needle, for dispensing at least part of the sample in the sample container into the reaction container; A reagent dispensing mechanism, including a reagent dispensing needle, for dispensing at least part of the reagent in the reagent container into the reaction container; A measuring component for measuring a reaction solution made of at least a mixture of a sample and a reagent; a cleaning liquid supply device, the cleaning liquid supply device being used to supply cleaning liquid to clean at least one of the sample dispensing needle, the reagent dispensing needle, the reaction container, and the stirring rod; an ultrasonic device for transmitting ultrasonic waves to a target liquid, wherein the target liquid includes one of the sample, the reagent, the mixed liquid, and the cleaning liquid; A control device, wherein the control device is configured to: sequentially use a first driving parameter and a second driving parameter to drive the ultrasonic device to transmit ultrasonic waves to the target liquid, and an operating parameter of the ultrasonic device in the process of using the first driving parameter to drive the ultrasonic device to transmit ultrasonic waves to the target liquid satisfies a preset condition; Wherein, the second driving parameter is smaller than the first driving parameter.

13. The sample analysis device according to claim 12, wherein: The control device is further configured to: control the ultrasonic device to start up with a first preset driving parameter, determine whether the working parameter of the ultrasonic device meets a preset condition; if so, drive the ultrasonic device with a second driving parameter; If not, increase the driving parameters of the ultrasonic device and execute the step of determining whether the working parameters of the ultrasonic device meet the preset conditions until the driving parameters of the ultrasonic device are greater than or equal to the second preset driving parameters. When the working parameters of the ultrasonic device meet the preset conditions, the driving parameters of the ultrasonic device are the first driving parameters.

14. The sample analysis device according to claim 12 or 13, characterized in that: The working parameters of the ultrasonic device include one of the load impedance, driving voltage, driving current, and driving power of the ultrasonic device.

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