Currarino syndrome auxiliary diagnosis system, method, equipment, medium and program product

Abstract

The invention provides a Curranino syndrome auxiliary diagnosis system, method and device, a medium and a program product, and relates to the technical field of medical biologication.The system comprises a first information obtaining module used for obtaining user information, and the user information comprises a growth period; the second information acquisition module is used for acquiring image data of the user; the Curranino syndrome diagnosis prompt module is used for outputting Curranino syndrome diagnosis prompt information according to the image data of the user; and the auxiliary diagnosis prompt module is used for outputting an auxiliary diagnosis prompt of a related part according to the expected malformation risk in the growth period under the condition that the Curraino syndrome diagnosis prompt determines that the user is the Curraino syndrome. By adopting the technical scheme provided by the embodiment of the invention, the auxiliary diagnosis prompt of the Currarino syndrome can be output based on the growth period and the image data of the user and based on different clinical symptoms and image expressions of the Currarino syndrome in different life growth periods, so as to assist in prompting possible malformation parts of the user, and improve the diagnosis accuracy of the Currarino syndrome. Therefore, the user is prompted to diagnose and treat related parts in time.

Description

Technical Field

[0001] The embodiments of the present invention relate to the field of medical biotechnology, and in particular to a Currarino syndrome auxiliary diagnosis system, method, device, medium and program product. Background Art

[0002] Currarino syndrome (CS) was first described by Italian doctor Guido Currarino in 1981 and named Currarino triad. The classic CS triad includes three congenital malformations: sacrococcygeal dysgenesis, anorectal malformation and presacral tumor. In 2000, Belloni et al. found that CS can be accompanied by other malformations in addition to the above three main signs, so it was renamed "Currarino syndrome". The syndrome is related to chromosome 7 microdeletion and spontaneous mutation, involving mutations in the MNX1 gene. CS is usually diagnosed in infancy, and about 80% of CS cases are diagnosed before at least 16 years of age. Due to the diverse phenotypes of CS, some patients are diagnosed only when they develop symptoms in adulthood. In clinical work, missed diagnosis is often caused by lack of systematic understanding of the disease. Early and complete diagnosis of CS is crucial to the patient's prognosis and quality of life at different growth stages. Summary of the invention

[0003] The embodiments of the present invention provide a Currarino syndrome auxiliary diagnosis system, method, device, medium and program product to provide a solution for auxiliary diagnosis of Currarino syndrome.

[0004] A first aspect of an embodiment of the present invention provides a Currarino syndrome auxiliary diagnosis system, the system comprising:

[0005] The first information acquisition module is used to acquire user information, wherein the user information includes: growth period;

[0006] The second information acquisition module is used to acquire the user's image data;

[0007] Currarino syndrome diagnosis prompt module, used to output Currarino syndrome diagnosis prompt information based on the user's image data;

[0008] The auxiliary diagnosis prompt module is used to output auxiliary diagnosis prompts for relevant parts according to the expected deformity risk during the growth period when the Currarino syndrome diagnosis prompt determines that the user has Currarino syndrome. When the growth period is infancy, the auxiliary diagnosis prompts for the pelvis, uterus, vagina, anus, rectum, urinary system, spinal cord and spine are output; when the growth period is adolescence, the auxiliary diagnosis prompts for the pelvis, uterus and vagina are output; when the growth period is adulthood, the auxiliary diagnosis prompts for the anus and rectum are output.

[0009] Optionally, the user information also includes: user's medical symptoms, and the Currarino syndrome diagnosis prompt module is used to:

[0010] When the user's symptoms include symptoms related to presacral tumors or anorectal malformation, Currarino syndrome diagnosis prompt information is output, and the Currarino syndrome diagnosis prompt information indicates to obtain the user's sacrum and coccyx image, and the sacrum and coccyx image is used to determine the development of the sacrum and coccyx. In the case of sacrum and coccyx dysplasia, the user is determined to have Currarino syndrome.

[0011] Optionally, the user information also includes: user's medical symptoms, and the Currarino syndrome diagnosis prompt module is used to: output Currarino syndrome diagnosis prompt information when the growth period is infancy and the medical symptoms include one or more of congenital anal atresia, anal stenosis, presacral tumors, and urinary system malformation-related symptoms.

[0012] Optionally, the Currarino syndrome diagnosis prompt module is further used to: output Currarino syndrome diagnosis prompt information when the growth period is adolescence and the symptoms include symptoms related to tethered cord and / or symptoms related to uterine malformation.

[0013] Optionally, the Currarino syndrome diagnosis prompt module is further used to: output Currarino syndrome diagnosis prompt information when the growth period is adulthood and the symptoms include anorectal malformation-related symptoms and / or presacral tumors.

[0014] A second aspect of an embodiment of the present invention provides a Currarino syndrome auxiliary diagnosis method, the method comprising: obtaining user information, determining a growth period corresponding to the user;

[0015] Acquiring image data of the user; the image data includes an image of the sacrum and coccyx;

[0016] Output Currarino syndrome diagnosis prompt information based on the user's image data;

[0017] When the Currarino syndrome diagnosis prompt determines that the user has Currarino syndrome, auxiliary diagnosis prompts for relevant parts are output according to the expected deformity risk during the growth period. When the growth period is infancy, auxiliary diagnosis prompts for the pelvis, uterus, vagina, anus, rectum, urinary system, spinal cord and spine are output; when the growth period is adolescence, auxiliary diagnosis prompts for the pelvis, uterus and vagina are output; when the growth period is adulthood, auxiliary diagnosis prompts for the anus and rectum are output.

[0018] Optionally, the user information also includes: user's medical symptoms, and outputting Currarino syndrome diagnosis prompt information based on the user's image data, including:

[0019] When the user's symptoms include symptoms related to presacral tumors or anorectal malformation, Currarino syndrome diagnosis prompt information is output, and the Currarino syndrome diagnosis prompt information indicates to obtain the user's sacrum and coccyx image, and the sacrum and coccyx image is used to determine the development of the sacrum and coccyx. In the case of sacrum and coccyx dysplasia, the user is determined to have Currarino syndrome.

[0020] Optionally, the user information also includes: the user's medical symptoms, and outputting Currarino syndrome diagnosis prompt information based on the user's image data, including: when the growth period is infancy and the medical symptoms include one or more of congenital anal atresia, anal stenosis, presacral tumors, and urinary system malformation-related symptoms, outputting Currarino syndrome diagnosis prompt information.

[0021] Optionally, outputting Currarino syndrome diagnosis prompt information based on the user's image data also includes:

[0022] When the growth period is adolescence and the symptoms include symptoms related to tethered cord and / or symptoms related to uterine malformation, Currarino syndrome diagnosis prompt information is output.

[0023] Optionally, outputting Currarino syndrome diagnosis prompt information based on the user's image data also includes: when the growth period is adulthood and the symptoms include anorectal malformation-related symptoms and / or presacral tumors, outputting Currarino syndrome diagnosis prompt information.

[0024] A third aspect of an embodiment of the present invention provides an electronic device, comprising a memory, a processor, and a computer program stored in the memory, wherein the processor executes the computer program to implement the Currarino syndrome auxiliary diagnosis system described in the first aspect above.

[0025] A third aspect of an embodiment of the present invention is a computer-readable storage medium, wherein instructions are stored in the computer-readable storage medium, and when the computer-readable storage medium is run on a computer, the computer executes the Currarino syndrome auxiliary diagnosis system described in the first aspect.

[0026] A third aspect of an embodiment of the present invention provides a computer program product, including a computer program, which, when executed by a processor, implements the Currarino syndrome auxiliary diagnosis system described in the first aspect above.

[0027] By adopting the technical solution provided in the embodiment of the present invention, an auxiliary diagnosis prompt of Currarino syndrome can be output based on the user's growth period and imaging data, and based on the different clinical symptoms and imaging manifestations of Currarino syndrome at different growth periods of life, so as to assist in prompting the user of possible deformities, so as to prompt the user to diagnose and treat the relevant parts in a timely manner. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings required for use in the description of the embodiments of the present invention will be briefly introduced below. Obviously, the accompanying drawings in the following description are only some embodiments of the present invention. For ordinary technicians in this field, other accompanying drawings can be obtained based on these accompanying drawings without paying creative work.

[0029] Figure 1 is a structural block diagram of a Currarino syndrome auxiliary diagnosis system provided by an embodiment of the present invention;

[0030] Figure 2 It is a flowchart of the steps of the Currarino syndrome auxiliary diagnosis method provided by an embodiment of the present invention. DETAILED DESCRIPTION

[0031] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0032] Currarino syndrome is an autosomal dominant genetic disease and a rare congenital developmental malformation. Its main manifestations are all or part of the congenital malformations of the triad of sacrococcygeal dysplasia, anorectal malformation and presacral tumors, and it may be accompanied by other pelvic system malformations. Domestic and foreign studies on Currarino syndrome are mostly case reports and reviews, and there are few related imaging literature. Due to the diversity of clinical and imaging manifestations of CS, the main symptoms of patients at different stages vary, and CS patients need to pay attention to them at different stages of their life cycle. In clinical work, it is usually because only some malformations in CS are paid attention to and only diagnosed for this, and CS cannot be fully and accurately diagnosed, resulting in missed diagnosis and misdiagnosis. Based on this, the inventor retrospectively analyzed and summarized the imaging manifestations and long-term clinical data of 16 patients with Currarino syndrome, in order to improve the understanding and diagnosis level of imaging physicians of this disease.

[0033] Specifically, in the embodiment of the present invention, the inventor retrospectively analyzed the clinical and imaging data of 16 patients diagnosed with Currarino syndrome admitted to a hospital from June 2006 to August 2022, including 8 males and 8 females, with an initial diagnosis age of 0 to 61 years old. The diagnosis of Currarino syndrome includes: ① sacral dysplasia; ② congenital anorectal malformation; ③ presacral mass. Complete CS is manifested as ①+②+③; partial CS is manifested as ①+② / ③ or only ①.

[0034] Among the 16 patients with Currarino syndrome, all patients underwent pelvic and sacrococcygeal imaging examinations, including MRI in 7 cases, CT in 5 cases, and both MRI and CT in 4 cases; 6 cases underwent abdominal X-ray and gastrointestinal angiography (or fistula angiography), and 2 cases underwent cystography.

[0035] In the embodiment of the present invention, two senior imaging diagnostic physicians jointly retrospectively observed and analyzed the imaging data of 16 CS patients and reached a consensus. The image analysis content includes: (1) the development of the sacrum and coccyx; (2) the presence of anal atresia or anal stenosis and the confirmation of the location of the stenosis; (3) the presence of presacral tumors, and the observation of the size, shape, signal / density, and relationship between the tumor and the sacral canal; (4) other congenital malformations of the pelvis. Clinical data analysis includes: reviewing medical history, surgical history and pathological examination results. (1) Confirming the time of the patient's first visit to this hospital and the main complaint; (2) Confirming whether the patient has a history of treatment for congenital anal atresia or anal stenosis at birth or infancy.

[0036] The specific analysis results are as follows:

[0037] 1. CS classification: Among the 16 cases of CS, 3 complete cases showed the classic triad of sacrococcygeal dysplasia, anorectal malformation and presacral mass; 13 partial cases, of which 10 had two characteristic malformations, namely sacrococcygeal dysplasia and anorectal malformation (7 cases) and sacrococcygeal dysplasia and presacral mass (3 cases); 3 cases had only one characteristic malformation, namely sacrococcygeal dysplasia, and all of them had other pelvic malformations except anorectal malformation and presacral mass. Both complete and partial CS can be combined with other pelvic system malformations, including uterine malformations (such as unicornuate uterus and rudimentary uterus, didelphys-diva malformation), urinary system malformations (such as complex urinary system malformations, solitary kidney, urethral atresia), tethered cord and / or spina bifida.

[0038] 2. Imaging manifestations (as shown in Table 1, where Table 1 shows the patient's clinical data and imaging manifestations):

[0039] All 16 cases had sacral and coccygeal deformities: 11 cases showed varying degrees of partial absence of the sacrum and coccyx, specifically partial or complete absence of the sacrum and coccygeal vertebrae below the S1 / S2 vertebrae, of which 3 cases had unilateral sacrum absence (all on the right side), manifested as the "scimitar sign"; 5 cases only showed abnormal development of the coccyx, including absence of the coccyx or a short coccyx.

[0040] Six patients had presacral masses: one was pathologically confirmed as a mature cystic teratoma, with low density, clear boundaries, and relatively uniform density on CT plain scan; MRI plain scan T1WI showed low signal with dot-shaped high signal, T2WI showed equal to slightly high signal, the internal signal was uneven, the boundary was clear, and enhanced scanning showed enhanced cyst wall enhancement, but no enhancement was found inside. Two cases were presacral myelomeningocele combined with epidermoid cysts. MRI scans showed an oval mass in the presacral space, with high signal on T2WI, clear boundaries, and smooth edges. The lesion was connected to the sacral canal through the sacral defect, and no enhancement was found on enhanced scanning. Another smaller oval mass was found in the presacral space, with slightly high signal on T2WI, clear boundaries, and clear boundaries with surrounding structures. Enhanced scanning showed enhanced edge enhancement of the lesion, but no enhancement was found inside. One case was presacral myelomeningocele. CT scan showed a round, slightly low-density mass in the presacral space with clear boundaries and uniform density. The lesion was connected to the sacral canal through the sacral defect, and no enhancement was found on enhanced scan. The other two cases were epidermoid cysts / dermoid cysts. A round cystic mass was seen in the presacral space. CT plain scan showed low density, MRI T1WI showed equal / low signal, T2WI showed high signal, clear boundaries, uniform signal, clear boundary between the lesion and adjacent tissues, and no enhancement was found on enhanced scan.

[0041] Nine patients had anorectal malformations: three had anorectal stenosis, with varying degrees of dilation of the rectum and sigmoid colon above the secondary stenosis; six had anal atresia, with the distal rectum not descending and forming a blind end, one with recto-vaginal fistula, and one with recto-urethral fistula.

[0042] In addition, 14 CS patients (3 complete and 11 incomplete) also had malformations of other pelvic systems, and some patients had multiple other malformations: 5 patients had uterine malformations, including 1 unicornuate uterus and rudimentary uterus, 2 uterus-double vagina malformation, and 2 uterus-double uterus malformation. 3 patients had urinary system malformations, including 1 complex urinary system malformation (hypospadias with penoscrotal transposition), 1 solitary kidney, and 1 urethral atresia. 7 patients had tethered spinal cord, 3 of whom had spina bifida.

[0043] Table 1 Clinical data and imaging manifestations of patients

[0044]

[0045]

[0046]

[0047] A total of 16 patients visited the hospital 23 times at different times. Thirteen patients visited the hospital during infancy and childhood. The reasons for the visits included congenital anal atresia or anal stenosis in 10 cases, presacral masses in 2 cases, and symptoms related to urinary tract malformation in 1 case. Four patients visited the hospital from school age to adolescence. The reasons for the visits included symptoms related to tethered cord (3 / 4) and symptoms related to uterine malformation (1 / 4). Six patients visited the hospital during adulthood. The reasons for the visits included symptoms related to anorectal malformation in 5 cases and presacral masses in 1 case. Sacrococcygeal dysplasia was an accidental discovery and was not the reason for the visit.

[0048] According to the phenotype of CS patients, it can be divided into complete type and partial type; complete type CS is manifested by the triad of sacral dysplasia, anorectal malformation and presacral mass; partial type CS is manifested by sacrococcygeal dysplasia combined with any one of presacral mass and anorectal malformation, or only sacrococcygeal dysplasia without other core manifestations. In this group of cases, there were 3 cases (18.75%) of complete type and 13 cases (81.25%) of partial type, of which 10 cases (62.5%) showed two core manifestations and 3 cases (18.75%) showed only sacrococcygeal dysplasia.

[0049] The clinical manifestations of CS are diverse and vary in severity. Patients often visit doctors with different complaints at different times and complete imaging examinations based on the corresponding complaints. Even if these examinations include the sacrum, sacral and coccygeal abnormalities are still easily overlooked. Therefore, children with sacral and coccygeal malformations should be alert to the possibility of CS; at the same time, children with anal atresia or stenosis should pay attention to carefully observe the development of the sacral and coccygeal bones and complete relevant examinations.

[0050] Infants and young children often present with defecation disorders or abdominal discomfort due to anorectal malformations. Patients of all ages may present with symptoms related to other system malformations associated with CS, which is more common in adolescence, among which symptoms related to tethered spinal cord and urogenital malformations are more common. Children with tethered cords should also be alert to the presence of sacral and coccygeal dysplasia.

[0051] Sacrococcygeal dysplasia is the core manifestation of CS. 100% of CS cases have sacral malformation. The types of malformation include complete or partial absence of the sacrum, absence or short development of the coccyx, and may also be combined with hemivertebrae, spondylolysis, vertebral fusion, etc. All 16 patients in this group had varying degrees of sacral malformation, with partial absence of the sacrum being the most common (50.0%, 8 / 16). Among them, 3 cases showed unilateral sacral absence, the characteristic of CS, namely the "scimitar sign" (18.8%, 3 / 16). The other two characteristic signs of CS are presacral tumors and anorectal stenosis; presacral tumors are usually benign lesions, including presacral myelomeningocele, teratoma, dermoid / epidermoid cyst, neuroenteric cyst, hamartoma, or a combination. In this group of cases, 6 cases had presacral tumors, with presacral myelomeningocele being the most common (50%, 3 / 6), 2 of which were complicated by epidermoid cysts, and 1 was a mature cystic teratoma (16.7%, 1 / 6); anorectal malformations usually manifest as congenital anal atresia or anal stenosis, and some patients have fistulas. In this group of cases, 9 cases had anorectal malformations, with anal atresia being the most common (66.7%, 6 / 9), 1 case was complicated by recto-vaginal fistula, and 1 case was complicated by recto-urethral fistula; and all of them were diagnosed at birth or infancy due to congenital anal atresia. CS can also be combined with other pelvic system developmental abnormalities, such as urogenital system developmental malformations, which may include horseshoe kidney, duplicated kidney malformation, unilateral renal agenesis, uterine vaginal duplication malformation, bicornuate uterus, uterine and vaginal agenesis, etc.; nervous system developmental abnormalities, including tethered spinal cord, spina bifida, etc. In this group of cases, 14 patients (87.5%, 14 / 16) had concomitant pelvic malformations of other systems, and some patients had multiple other malformations.

[0052] The mechanism of this disease is still unclear. Currently, many studies believe that the disease is caused by abnormal differentiation of the endoderm and neuroectoderm. In addition, combined with previous literature and observations of this group of patients, further hypotheses and analyses are proposed for the above mechanism: the core mechanism of CS considered in the present embodiment is the abnormal development of the ectoderm. Normally, bones develop from the ectoderm, so abnormal ectoderm development can lead to sacral and coccygeal dysplasia, which explains the core sign that 100% of CS patients have partial or complete absence of the sacral and coccygeal bones above the pelvic diaphragm level. CS patients may develop atresia or stenosis at the pelvic diaphragm level due to the obstruction of the downward development of the rectum and anal canal. Presacral tumors are usually dermoid / epidermoid cysts or teratomas. Epidermoid / dermoid cysts are all developed from the ectoderm. Abnormal ectoderm development can lead to the occurrence of epidermoid / dermoid cysts; and according to literature reports, if the endoderm and neuroectoderm components are still combined with the mesoderm components that migrate to the presacral space during somite development, a teratoma will be formed. This hypothesis can also explain other malformations associated with CS to a certain extent: for example, the uterus can have abnormal vertical or horizontal fusion at the level of the pelvic diaphragm. Abnormal horizontal fusion of the uterus can lead to developmental abnormalities such as double uterus and double vagina; the obstruction of the downward development of the bladder neck / urethra can develop into developmental abnormalities such as congenital urethral stenosis or abnormal urethral opening. Therefore, in the embodiments of the present invention, considering that multiple pelvic systems such as the sacrum, rectum and anorectal canal, uterus and urinary tract have different degrees of obstruction in downward development at the level of the pelvic diaphragm, this may be related to the abnormal development of the ectoderm blocking the downward development of multiple germ layer structures at the level of the pelvic diaphragm. This related mechanism needs further exploration and verification.

[0053] CT and MRI are the main diagnostic methods for CS and have different diagnostic values. CT can more clearly show the degree and type of sacrococcygeal deformity through multi-planar reconstruction and three-dimensional reconstruction technology. MRI is more advantageous in observing the location of anal stenosis, the size and composition of the presacral mass and its relationship with surrounding tissues. It is also superior to other examinations in evaluating concurrent pelvic system malformations (such as tethering and uterine malformation). Selecting appropriate imaging techniques according to the different deformity components of CS to achieve multi-directional and multi-angle imaging is helpful for the early and accurate diagnosis of CS.

[0054] Since the symptoms of CS at different stages vary greatly, the time when the patient seeks treatment also becomes one of the important diagnostic bases. Therefore, not only does the three-dimensional imaging technology need to be used in image diagnosis to achieve multi-directional and multi-angle observation, but a comprehensive assessment also needs to be made in combination with the patient's growth period. Therefore, the embodiment of the present invention believes that the diagnosis of Currarino syndrome is not only a "three-dimensional diagnosis" at the imaging level, but also a "four-dimensional diagnosis" that combines three-dimensional imaging with the growth timeline; a fuller understanding of the different clinical symptoms and imaging manifestations of CS at different stages of life can improve the understanding of the disease and achieve an accurate early diagnosis of CS.

[0055] Based on the exploratory research of the above embodiments, the inventor proposes: based on the user's growth period and imaging data, and based on the different clinical symptoms and imaging manifestations of Currarino syndrome at different growth periods of life, auxiliary diagnosis prompts for Currarino syndrome can be output to assist in prompting the user of possible deformities, so as to prompt the user to diagnose and treat the relevant parts in a timely manner.

[0056] Specifically, the embodiment of the present invention provides a Currarino syndrome auxiliary diagnosis system, such as Figure 1 As shown, it shows a structural block diagram of the Currarino syndrome auxiliary diagnosis system provided by an embodiment of the present invention. Specifically, the system includes:

[0057] The first information acquisition module 101 is used to acquire user information, and the user information includes: growth period;

[0058] The second information acquisition module 102 is used to acquire the user's image data;

[0059] Currarino syndrome diagnosis prompt module 103, used to output Currarino syndrome diagnosis prompt information according to the user's image data;

[0060] The auxiliary diagnosis prompt module 104 is used to output auxiliary diagnosis prompts for relevant parts according to the expected deformity risk during the growth period when the Currarino syndrome diagnosis prompt determines that the user has Currarino syndrome. When the growth period is infancy, auxiliary diagnosis prompts for the pelvis, uterus, vagina, anus, rectum, urinary system, spinal cord and spine are output; when the growth period is adolescence, auxiliary diagnosis prompts for the pelvis, uterus and vagina are output; when the growth period is adulthood, auxiliary diagnosis prompts for the anus and rectum are output.

[0061] In the embodiment of the present invention, the user information may also include: user personal information (eg, age, gender, etc.), user medical symptoms, user medical history, etc.

[0062] In the embodiment of the present invention, the image data of the user may be CT image data and MRI image data.

[0063] In the embodiment of the present invention, the CT examination equipment and parameters specifically include: using Canon Aquilion 64-slice spiral CT, the scanning range is from the diaphragm to the pelvic floor. The tube voltage is 120kV, the tube current is 200mAs, the layer thickness is 5mm, the layer spacing is 5mm, and the pitch is 1. The enhanced scanning contrast agent uses iopromide (300mgI / ml), and 80-100ml is injected at a flow rate of 3ml / s, and the arterial phase (delay of 30s) and venous phase (delay of 90s) scanning are performed. The MPR method is used for image post-processing.

[0064] MR examination equipment and parameters include: Siemens Magnetom Trio 3.0T magnetic resonance scanner, patients in supine position, feet first, and body matrix coil. Scan T1WI, T2WI, TSE fat suppression, coronal and sagittal T2WI, enhanced scanning using T1_vibe_fs sequence multi-phase scanning, injection of gadopentetate dimeglumine (Gd-DTPA) 15-20ml (0.1mmol / kg body weight) at an injection flow rate of 2.0-2.5m / s.

[0065] In an embodiment of the present invention, considering that the symptoms of CS at different stages vary greatly, it is proposed to output an auxiliary diagnosis prompt of Currarino syndrome based on the user information and the image data. For example, if a user visits a doctor for anorectal malformation during infancy, it can be prompted that the user is likely to suffer from Currarino syndrome, and the user is prompted to undergo further examinations, such as sacral and coccygeal imaging examinations, to confirm whether the user suffers from Currarino syndrome.

[0066] In the embodiment of the present invention, according to the analysis of relevant cases, it is found that Currarino syndrome is complicated by malformation symptoms in multiple parts. Therefore, after the user is diagnosed with Currarino syndrome, if the user is in infancy at this time, a comprehensive examination of the relevant parts can be performed to promptly discover the parts where the user may have abnormalities. The expected malformation risk of the pelvis, uterus and vagina of adolescent users is higher, and the user can be prompted to promptly perform pelvic, uterus and vaginal examinations during this growth period. The expected malformation risk of the anus and rectum of adult users is higher, and the user can be prompted to promptly perform an anus and rectum examination during this growth period.

[0067] In the embodiment of the present invention, after a patient visits a doctor due to different symptoms and is diagnosed with Currarino syndrome, the user may be prompted to perform examinations of corresponding parts at different growth stages.

[0068] In the embodiment of the present invention, the auxiliary diagnosis prompt of Currarino syndrome is used to prompt the user of the possibility of suffering from Currarino syndrome, prompt the user to undergo further examinations, and prompt the patient of abnormal parts that may occur in different growth periods, so as to prompt the patient to examine the corresponding parts in the corresponding growth period to achieve timely diagnosis and timely intervention.

[0069] In an optional implementation, the user information further includes: user's symptoms, and the Currarino syndrome diagnosis prompt module 103 is used to:

[0070] When the user's symptoms include symptoms related to presacral tumors or anorectal malformation, Currarino syndrome diagnosis prompt information is output, and the Currarino syndrome diagnosis prompt information indicates to obtain the user's sacrum and coccyx image, and the sacrum and coccyx image is used to determine the development of the sacrum and coccyx. In the case of sacrum and coccyx dysplasia, the user is determined to have Currarino syndrome.

[0071] In the embodiment of the present invention, it is considered that the diagnosis of Currarino syndrome includes: ① sacral dysplasia; ② congenital anorectal malformation; ③ presacral tumor. Complete CS is manifested as ①+②+③; partial CS is manifested as ①+② / ③ or only ①, wherein both complete and partial types will have sacral dysplasia. In the clinical diagnosis process, the user's symptoms may only be related to congenital anorectal malformation or only related to presacral tumors. In this case, there may be misdiagnosis and missed diagnosis. Based on this, the embodiment of the present invention proposes that when the user's symptoms include: presacral tumor-related symptoms or anorectal malformation-related symptoms, a prompt for a sacral imaging examination is output for the user to determine whether the user suffers from Currarino syndrome according to the results of the sacral imaging examination. After the user undergoes a sacral imaging examination, the professional can determine the user's sacral development through the sacral imaging, and further determine whether the user suffers from Currarino syndrome.

[0072] Specifically, in the embodiment of the present invention, either or both of CT and MRI examinations can be used to perform sacral and coccygeal imaging examinations.

[0073] In an optional embodiment, the Currarino syndrome diagnosis prompt module 103 is used to:

[0074] When the growth period is infants and young children, and the medical symptoms include one or more of congenital anal atresia, anal stenosis, presacral tumors, and urinary system malformation-related symptoms, Currarino syndrome diagnosis prompt information is output.

[0075] In an optional embodiment, the Currarino syndrome diagnosis prompt module 103 is further used for:

[0076] When the growth period is adolescence and the symptoms include symptoms related to tethered cord and / or symptoms related to uterine malformation, Currarino syndrome diagnosis prompt information is output.

[0077] In an optional embodiment, the Currarino syndrome diagnosis prompt module 103 is further used for:

[0078] When the growth period is adulthood and the symptoms include anorectal malformation-related symptoms and / or presacral tumors, Currarino syndrome diagnosis prompt information is output.

[0079] In the embodiment of the present invention, considering that there are great differences in the symptoms of CS at different stages, it is also proposed that whether the user may suffer from Currarino syndrome can be judged according to the growth stage of the user and the symptoms of the user, and the patient can be prompted to undergo a sacral and coccygeal imaging examination to obtain a sacral and coccygeal image, so that professionals can determine the user's sacral and coccygeal development through the sacral and coccygeal image, and further determine whether the user suffers from Currarino syndrome.

[0080] Based on the same inventive concept, the present invention provides a method for diagnosing Currarino syndrome. Figure 2 As shown, it shows a flowchart of the steps of the Currarino syndrome diagnosis method provided by an embodiment of the present invention. Specifically, the method includes:

[0081] S201, obtaining user information and determining the growth period corresponding to the user;

[0082] S202, obtaining image data of the user;

[0083] S203, outputting Currarino syndrome diagnosis prompt information according to the user's image data;

[0084] S204, when the Currarino syndrome diagnosis prompt determines that the user has Currarino syndrome, outputs auxiliary diagnosis prompts for relevant parts according to the expected deformity risk during the growth period; when the growth period is infancy, outputs auxiliary diagnosis prompts for the pelvis, uterus, vagina, anus, rectum, urinary system, spinal cord and spine; when the growth period is adolescence, outputs auxiliary diagnosis prompts for the pelvis, uterus and vagina; when the growth period is adulthood, outputs auxiliary diagnosis prompts for the anus and rectum.

[0085] In an optional implementation, the user information further includes: user's medical symptoms, and step S203 includes:

[0086] When the user's symptoms include symptoms related to presacral tumors or anorectal malformation, Currarino syndrome diagnosis prompt information is output, and the Currarino syndrome diagnosis prompt information indicates to obtain the user's sacrum and coccyx image, and the sacrum and coccyx image is used to determine the development of the sacrum and coccyx. In the case of sacrum and coccyx dysplasia, the user is determined to have Currarino syndrome.

[0087] In an optional implementation, the user information further includes: user's medical symptoms, and step S203 includes:

[0088] When the growth period is infants and young children, and the medical symptoms include one or more of congenital anal atresia, anal stenosis, presacral tumors, and urinary system malformation-related symptoms, Currarino syndrome diagnosis prompt information is output.

[0089] In an optional implementation, the step S203 further includes:

[0090] When the growth period is adolescence and the symptoms include symptoms related to tethered cord and / or symptoms related to uterine malformation, Currarino syndrome diagnosis prompt information is output.

[0091] In an optional implementation, the step S203 further includes:

[0092] When the growth period is adulthood and the symptoms include anorectal malformation-related symptoms and / or presacral tumors, Currarino syndrome diagnosis prompt information is output.

[0093] Based on the same inventive concept, an embodiment of the present invention also provides an electronic device, including a memory, a processor, and a computer program stored on the memory, characterized in that the processor executes the computer program to implement the Currarino syndrome auxiliary diagnosis system described in any of the above embodiments.

[0094] Based on the same inventive concept, the present invention also provides a computer-readable storage medium, in which instructions are stored. When the computer-readable storage medium is run on a computer, the computer executes the Currarino syndrome auxiliary diagnosis system described in any of the above embodiments.

[0095] Based on the same inventive concept, an embodiment of the present invention further provides a computer program product, including a computer program, which, when executed by a processor, implements the Currarino syndrome auxiliary diagnosis system described in any of the above embodiments.

[0096] Although the preferred embodiments of the present invention have been described, those skilled in the art may make additional changes and modifications to these embodiments once they have learned the basic creative concept. Therefore, the appended claims are intended to be interpreted as including the preferred embodiments and all changes and modifications that fall within the scope of the embodiments of the present invention.

[0097] The above is a detailed introduction to the Currarino syndrome auxiliary diagnosis system, method, device, medium and program product provided by the present invention. Specific examples are used in this article to illustrate the principles and implementation methods of the present invention. The description of the above embodiments is only used to help understand the method of the present invention and its core idea; at the same time, for those skilled in the art, according to the idea of ​​the present invention, there will be changes in the specific implementation method and application scope. In summary, the content of this specification should not be understood as limiting the present invention.

Claims

1. Currarino syndrome auxiliary diagnosis system, characterized in that: The system comprises: The first information acquisition module is used to acquire user information, wherein the user information includes: growth period; The second information acquisition module is used to acquire the user's image data; Currarino syndrome diagnosis prompt module, used to output Currarino syndrome diagnosis prompt information based on the user's image data; The auxiliary diagnosis prompt module is used to output auxiliary diagnosis prompts for relevant parts according to the expected deformity risk during the growth period when the Currarino syndrome diagnosis prompt determines that the user has Currarino syndrome. When the growth period is infancy, the auxiliary diagnosis prompts for the pelvis, uterus, vagina, anus, rectum, urinary system, spinal cord and spine are output; when the growth period is adolescence, the auxiliary diagnosis prompts for the pelvis, uterus and vagina are output; when the growth period is adulthood, the auxiliary diagnosis prompts for the anus and rectum are output.

2. The Currarino syndrome auxiliary diagnosis system according to claim 1, characterized in that: The user information also includes: the user's medical symptoms, and the Currarino syndrome diagnosis prompt module is used to: when the user's medical symptoms include symptoms related to presacral tumors or symptoms related to anorectal malformations, output Currarino syndrome diagnosis prompt information, the Currarino syndrome diagnosis prompt information instructs to obtain the user's sacrum and coccyx image, the sacrum and coccyx image is used to determine the development of the sacrum and coccyx, and in the case of sacrum and coccyx dysplasia, determine that the user has Currarino syndrome.

3. The Currarino syndrome auxiliary diagnosis system according to claim 1, characterized in that: The user information also includes: user's medical symptoms, and the Currarino syndrome diagnosis prompt module is used to output Currarino syndrome diagnosis prompt information when the growth period is infancy and the medical symptoms include one or more of congenital anal atresia, anal stenosis, presacral tumors, and urinary system malformation-related symptoms.

4. The Currarino syndrome auxiliary diagnosis system according to claim 3, characterized in that: The Currarino syndrome diagnosis prompt module is also used to: output Currarino syndrome diagnosis prompt information when the growth period is adolescence and the symptoms include symptoms related to tethered cord and / or symptoms related to uterine malformation.

5. The Currarino syndrome auxiliary diagnosis system according to claim 4, characterized in that: The Currarino syndrome diagnosis prompt module is also used to: output Currarino syndrome diagnosis prompt information when the growth period is adulthood and the symptoms include anorectal malformation-related symptoms and / or presacral tumors.

6. A method for auxiliary diagnosis of Currarino syndrome, characterized in that: The method comprises: Obtain user information and determine the corresponding growth period of the user; Obtain user's image data; Output Currarino syndrome diagnosis prompt information based on the user's image data; When the Currarino syndrome diagnosis prompt determines that the user has Currarino syndrome, auxiliary diagnosis prompts for relevant parts are output according to the expected deformity risk during the growth period. When the growth period is infancy, auxiliary diagnosis prompts for the pelvis, uterus, vagina, anus, rectum, urinary system, spinal cord and spine are output; when the growth period is adolescence, auxiliary diagnosis prompts for the pelvis, uterus and vagina are output; when the growth period is adulthood, auxiliary diagnosis prompts for the anus and rectum are output.

7. The Currarino syndrome auxiliary diagnosis method according to claim 5, characterized in that: The user information also includes: the user's medical symptoms, and the Currarino syndrome diagnosis prompt information is output based on the user's image data, including: When the user's symptoms include symptoms related to presacral tumors or anorectal malformation, Currarino syndrome diagnosis prompt information is output, and the Currarino syndrome diagnosis prompt information indicates to obtain the user's sacrum and coccyx image, and the sacrum and coccyx image is used to determine the development of the sacrum and coccyx. In the case of sacrum and coccyx dysplasia, the user is determined to have Currarino syndrome.

8. An electronic device comprising a memory, a processor and a computer program stored in the memory, characterized in that: The processor executes the computer program to implement the Currarino syndrome auxiliary diagnosis system according to any one of claims 1 to 5.

9. A computer-readable storage medium having a computer program stored thereon, characterized in that: When the computer program is executed by a processor, the Currarino syndrome auxiliary diagnosis system as described in any one of claims 1 to 5 is implemented.

10. A computer program product, comprising a computer program, characterized in that When the computer program is executed by a processor, the Currarino syndrome auxiliary diagnosis system as described in any one of claims 1 to 5 is implemented.

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