Acne-removing and relieving composition, cosmetic and preparation method of acne-removing and relieving composition

Abstract

The invention discloses an acne-removing and relieving composition, a cosmetic and a preparation method of the acne-removing and relieving composition, the acne-removing and relieving composition is prepared from quaternary ammonium salt-73, an anti-allergy agent, centella asiatica total glycosides, allantoin, nicotinamide, o-cymene-5-ol, bisabolol, surfactin and ethyoxyl diglycol. The acne removing and relieving composition disclosed by the invention is prepared from the following nine materials: quaternary ammonium salt-73, anti-allergy, asiaticoside, allantoin, nicotinamide, o-cymene-5-ol, bisabolol, surfactin and ethyoxyl diglycol, and the nine materials are matched with one another, so that the effects of resisting bacteria, resisting inflammation, relieving, repairing, controlling oil and promoting absorption can be realized, and the acne removing and relieving effects are achieved; the skin barrier can be repaired after long-term use.

Description

Technical Field

[0001] The invention belongs to the technical field of cosmetics, and in particular relates to an acne-removing and soothing composition, cosmetics and a preparation method thereof. Background Art

[0002] As the largest organ in the human body, the skin not only bears the important responsibility of protecting the internal tissues from the external environment, but also has multiple functions such as regulating body temperature and sensing external stimuli. In particular, the facial skin, because of its delicate and sensitive structure, is more susceptible to external factors, such as ultraviolet radiation, air pollution, etc., which can cause various skin problems, the most common of which is acne (i.e. pimples). The formation of pimples is a complex physiological process involving multiple links such as excessive sebum secretion, abnormal keratinization of hair follicles, microbial (mainly Propionibacterium acnes) infection and inflammatory response. In addition, endocrine disorders, bad living habits (such as lack of sleep, improper diet), mental stress, etc. are also important factors that induce or aggravate acne.

[0003] In recent years, the anti-acne cosmetics market has shown a booming trend. In order to cater to this market demand, many cosmetics companies have launched various care products for acne-prone skin. Among these anti-acne products, products based on natural plant ingredients have gradually stood out and become the darling of the market. However, the acne-removing effect of natural plant anti-acne products often depends on the simple superposition of different plant ingredients, which to a certain extent limits the room for improvement of product effects. At present, although most natural plant anti-acne products can provide basic soothing and anti-inflammatory effects, there is still much room for improvement in terms of in-depth solution of acne problems and accelerated acne healing.

[0004] Therefore, there is an urgent need for an acne-removing and soothing composition, cosmetics and preparation methods thereof to solve the deficiencies of the prior art problems. Summary of the invention

[0005] In view of the above problems, the purpose of the present invention is to provide an acne-removing and soothing composition, a cosmetic and a preparation method thereof. The various components in the acne-removing and soothing composition cooperate with each other and work synergistically to achieve the effect of acne-removing and soothing, and long-term use can repair the skin barrier.

[0006] To achieve the above objectives, the first aspect of the present invention provides an acne-removing and soothing composition, comprising quaternary ammonium salt-73, sominjia, total glucosides of Centella asiatica, allantoin, niacinamide, o-cymene-5-ol, bisabolol, o-tingmin, and ethoxydiglycol.

[0007] The acne-removing and soothing composition of the present invention selects nine substances, including quaternary ammonium salt-73, Shuminjia, total glycosides of Centella asiatica, allantoin, niacinamide, o-cymene-5-ol, bisabolol, Otinmin, and ethoxydiglycol, as raw materials. These nine raw materials cooperate with each other to achieve antibacterial and anti-inflammatory, soothing, repairing, oil control, and absorption-promoting effects, thereby achieving acne-removing and soothing effects, and long-term use can repair the skin barrier. Its specific mechanism of action is as follows.

[0008] (1) Quaternary ammonium salt-73 can effectively kill or inhibit the bacteria that cause acne, especially Propionibacterium acnes, and reduce the occurrence of inflammation; it also helps to inhibit the formation of melanin and helps to lighten the spots left after acne; at the same time, o-cymene-5-ol has strong penetration and can penetrate deep into the skin layer, effectively inhibiting the reproduction of Propionibacterium acnes, reducing inflammation and the formation of acne. Therefore, the combination of quaternary ammonium salt-73 and o-cymene-5-ol can produce significant synergistic effects in antibacterial and anti-inflammatory aspects.

[0009] (2) However, the strong antibacterial effect of quaternary ammonium salt-73 can also cause certain damage to skin cells, resulting in impaired skin barrier function, thereby causing sensitive reactions such as dryness, desquamation, and redness and swelling, while the strong permeability of o-cymene-5-ol can also cause temporary damage to the skin barrier, making the skin more susceptible to external stimuli. Based on this, the present application also introduces Shuminjia, bisabolol, allantoin, Centella asiatica total glycosides, and Aotingmin. Shuminjia contains herbal ingredients such as astragalus, siler, gastrodia, calendula, and albizzia, which have natural anti-inflammatory, antioxidant, soothing and repairing effects, can reduce skin sensitivity and promote skin self-repair; bisabolol has significant anti-inflammatory and sedative effects, can effectively reduce skin redness and inflammatory reactions, and promote skin recovery; allantoin can promote the renewal and repair of skin cells, accelerate wound healing, and thus help reduce the formation of acne scars; Total glucosides of Centella asiatica can promote the synthesis of collagen, repair skin damage caused by acne and improve skin texture; Otingmin helps maintain the microecological balance on the skin surface, inhibits the growth of harmful bacteria, and indirectly supports skin health and inhibits the formation of acne by creating an environment conducive to the survival of beneficial bacteria; therefore, the combination of Shuminjia, bisabolol, allantoin, total glucosides of Centella asiatica and Otingmin can produce significant synergistic effects in soothing and repairing, and can effectively alleviate skin sensitivity and external stimulation reactions caused by quaternary ammonium salt-73 and o-cymene-5-ol.

[0010] (3) However, long-term use of allantoin may cause skin irritation and central nervous system reactions, leading to dry and irritated skin, which may aggravate acne problems; at the same time, long-term use of Centella asiatica total glycosides may cause overactivity of skin cells, thereby destroying the natural balance of the skin, impairing the skin barrier function, and increasing sensitivity to external stimuli; and long-term use of Aotingmin may excessively inhibit the growth of certain bacteria, leading to an imbalance in the skin microecology, which will destroy the natural barrier function of the skin and aggravate acne problems. Based on this, the present application also introduces niacinamide and ethoxydiglycol. Niacinamide has a variety of skin care effects, which can reduce skin irritation and inflammatory reactions caused by long-term use of Aotingmin and Centella asiatica total glycosides, and help repair damaged skin barriers; ethoxydiglycol can increase skin hydration and reduce skin dryness and irritation problems caused by long-term use of allantoin. More importantly, niacinamide can inhibit the production of fatty acids and triglycerides in sebum, thereby reducing sebum secretion and the occurrence of acne; ethoxydiglycol has a good solubilizing effect, which can help other ingredients to dissolve and stabilize better, so that they can act on the skin more effectively. Therefore, niacinamide and ethoxydiglycol can work together to control oil secretion and promote skin absorption.

[0011] Furthermore, the present invention includes, by weight, 1 to 10 parts of quaternary ammonium salt-73, 1 to 5 parts of sourmin, 0.1 to 0.5 parts of total Centella asiatica glucosides, 0.1 to 1.0 parts of allantoin, 1 to 5 parts of niacinamide, 0.01 to 0.1 parts of o-cymene-5-ol, 0.1 to 1 parts of bisabolol, 1 to 5 parts of autinamine, and 1 to 5 parts of ethoxydiglycol.

[0012] Correspondingly, the second aspect of the present invention also provides a cosmetic, including a cosmetic external dosage form matrix and the above-mentioned acne-removing and soothing composition, wherein the cosmetic external dosage form matrix includes water, a thickener, a moisturizer, an emulsifier, an antibacterial agent, an emollient and a pH neutralizer.

[0013] Furthermore, the dosage form of the cosmetic of the present invention is at least one of a paste, an aqueous solution, an emulsion, an essence and a cream.

[0014] Furthermore, the cosmetic external dosage form matrix of the present invention includes, by weight, 70 to 80 parts of water, 0.1 to 1 part of a thickener, 1 to 10 parts of a moisturizer, 2 to 10 parts of an emulsifier, 1 to 15 parts of an emollient, 0.1 to 4 parts of an antibacterial agent, and 0.05 to 1 part of a pH neutralizer.

[0015] Further, the moisturizing agent of the present invention includes at least one of betaine and 1,2-hexanediol.

[0016] Furthermore, the emulsifier of the present invention comprises At least one of Care 165MB and EMULIUM MELLIFERA MB.

[0017] Further, the emollient of the present invention includes at least one of cetearyl alcohol, isononyl isononanoate, dimethicone, squalane and tocopherol acetate.

[0018] Accordingly, the third aspect of the present invention also provides a method for preparing a cosmetic, comprising the steps of:

[0019] (1) mixing water, a thickener, allantoin and a humectant, and heating and stirring to obtain an aqueous phase;

[0020] (2) mixing bisabolol, an emulsifier, and an emollient, and heating and stirring to obtain an oil phase;

[0021] (3) mixing the aqueous phase and the oil phase, performing vacuum insulation, and then performing homogenization;

[0022] (4) cooling the mixture obtained in step (3) to 60-65° C., adding a pH neutralizer and stirring uniformly;

[0023] (5) cooling the mixture obtained in step (4) to 50-55° C., adding an antibacterial agent and o-cymene-5-ol and stirring evenly;

[0024] (6) cooling the mixture obtained in step (5) to below 40° C., adding Shuminjia, quaternary ammonium salt-73, total glycosides of Centella asiatica, niacinamide, Otingmin, and ethoxydiglycol, and stirring evenly;

[0025] (7) Cool the mixture obtained in step (6) to room temperature and fill it.

[0026] Further, step (1) of the present invention comprises heating to 75-80°C;

[0027] Furthermore, step (2) of the present invention comprises heating to 70-75°C. DETAILED DESCRIPTION

[0028] The following is a further detailed description of the claims of the present invention in conjunction with specific implementation methods, but does not constitute any limitation to the present invention. Any limited modifications made by anyone within the scope of protection of the claims of the present invention are still within the scope of protection of the claims of the present invention.

[0029] The present invention provides an acne-removing and soothing composition, comprising quaternary ammonium salt-73, sominjia, total glycosides of Centella asiatica, allantoin, nicotinamide, o-cymene-5-ol, bisabolol, aotingmin, and ethoxydiglycol. Further, by mass, it comprises 1 to 10 parts of quaternary ammonium salt-73, 1 to 5 parts of sominjia, 0.1 to 0.5 parts of total glycosides of Centella asiatica, 0.1 to 1.0 parts of allantoin, 1 to 5 parts of nicotinamide, 0.01 to 0.1 parts of o-cymene-5-ol, 0.1 to 1 parts of bisabolol, 1 to 5 parts of aotingmin, and 1 to 5 parts of ethoxydiglycol.

[0030] Among them, the content of quaternary ammonium salt-73 (also known as piaoning) can be but not limited to 1 part, 3 parts, 5 parts, 7 parts, 8.5 parts, 9 parts, and 10 parts. Quaternary ammonium salt-73 is a powerful bactericidal agent that can effectively inhibit the growth of various bacteria, especially Propionibacterium acnes, which is one of the main pathogenic factors of acne. In addition, quaternary ammonium salt-73 also has whitening activity and can effectively inhibit the formation of melanin, thereby helping to alleviate the skin pigmentation problem caused by acne. Therefore, quaternary ammonium salt-73 can not only reduce the occurrence of acne, but also improve the skin spots caused by acne, making the skin look more uniform and healthy.

[0031] Among them, the content of Shuminjia can be but not limited to 1 part, 1.5 parts, 2 parts, 2.7 parts, 3.5 parts, 4.2 parts, 5.0 parts. Shuminjia contains a variety of herbal ingredients such as astragalus, siler, gastrodia, calendula, and albizzia. These ingredients are carefully matched to target the mechanism that causes skin sensitivity and exert their effects through multi-dimensional repair, anti-inflammatory and soothing, anti-aging and absorption-promoting effects.

[0032] Among them, the content of total glycosides of Centella asiatica can be but not limited to 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, and 0.5 parts. When the skin is damaged by inflammatory diseases such as acne, the production of collagen may be affected, leading to scar formation and deterioration of skin texture. Total glycosides of Centella asiatica is an active ingredient extracted from Centella asiatica. Total glycosides of Centella asiatica can not only inhibit inflammatory response, but also effectively promote the synthesis of collagen, which is especially important for repairing skin damage caused by acne. However, long-term use of total glycosides of Centella asiatica may cause overactivity of skin cells, thereby destroying the natural balance of the skin, impairing the skin barrier function, and increasing sensitivity to external stimuli.

[0033] Among them, the content of allantoin can be but not limited to 0.1 parts, 0.8 parts, 1.5 parts, 3 parts, 5 parts, 7 parts, 8.5 parts, 9 parts, and 10 parts. Allantoin can stimulate the division and proliferation of epidermal cells, accelerate the shedding of the aging stratum corneum, and thus promote the generation of new and healthy skin cells. For acne patients, this means that damaged skin tissue can be restored faster and scar formation can be reduced. Allantoin also has a mild anti-inflammatory effect, which can reduce skin redness and inflammation, providing immediate relief for acne patients; at the same time, allantoin can also help the skin retain moisture, help maintain the integrity of the skin barrier, and promote a healthier skin condition. However, long-term use of allantoin may cause skin irritation and central nervous system reactions, leading to dry and irritated skin, which may aggravate acne problems.

[0034] The content of niacinamide can be, but is not limited to, 1 part, 1.8 parts, 2.5 parts, 3.2 parts, 4.1 parts, and 5 parts. Sebum is a grease secreted by sebaceous glands, mainly composed of fatty acids and triglycerides. Excessive sebum secretion can lead to clogged pores, form acne, and then develop into acne. Niacinamide can directly affect the function of sebaceous glands, reduce the production of sebum by inhibiting the synthesis of fatty acids and triglycerides. At the same time, niacinamide also has anti-inflammatory properties, which helps to reduce redness and pain and accelerate the healing of acne by reducing the release of inflammatory mediators (such as interleukin-8 and tumor necrosis factor-α).

[0035] Among them, the content of o-cymene-5-ol can be but not limited to 0.01 parts, 0.03 parts, 0.06 parts, 0.08 parts, and 0.1 parts. o-cymene-5-ol is a natural compound extracted from thyme and other plants, with strong antibacterial and anti-inflammatory properties. It also has good skin permeability and can quickly penetrate the surface of the skin and reach deep into the hair follicles. This feature enables it to act more effectively on acne sites, effectively inhibit the reproduction of Propionibacterium, and reduce inflammation and acne formation. In addition, if used for a long time, the strong permeability of o-cymene-5-ol may also cause temporary damage to the skin barrier, making the skin more susceptible to external stimuli.

[0036] Wherein, the content of bisabolol may be, but is not limited to, 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, and 1 part. Bisabolol is a natural ingredient extracted from chamomile, which can effectively inhibit the production of inflammatory mediators, such as interleukins (IL-1β, IL-6), tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2). These inflammatory mediators play a key role in skin inflammatory reactions, and by reducing their production, the redness and inflammatory reaction of the skin can be significantly reduced. At the same time, bisabolol has a mild sedative effect, which can relieve skin discomfort caused by acne, such as itching, stinging and burning.

[0037] Among them, the content of Aotingmin can be but not limited to 1 part, 1.2 parts, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, and 5 parts. Aotingmin can maintain the weakly acidic environment of the skin (pH = 4.5-5.5), promote beneficial bacteria to resist harmful bacteria, keep the skin in a stable state, reduce body allergies, and thus reduce sensitivity to external stimuli. However, long-term use of Aotingmin may excessively inhibit the growth of certain bacteria, leading to an imbalance in the skin's microecology, which can destroy the skin's natural barrier function and aggravate acne problems.

[0038] The content of ethoxydiglycol can be, but is not limited to, 1 part, 1.2 parts, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, and 5 parts. Ethoxydiglycol can not only enhance the hydration capacity of the skin, but also, due to its excellent solubilizing properties, can help other ingredients to be better dissolved and stabilized in the formula, which enables these ingredients to act more effectively on the skin.

[0039] Accordingly, the present invention also provides the use of the above-mentioned acne-removing and soothing composition in cosmetics, and the cosmetics can be formed by mixing the acne-removing and soothing composition with a cosmetic external dosage form matrix. Specifically, the cosmetic external dosage form matrix includes water, a thickener, a moisturizer, an emulsifier, an antibacterial agent, an emollient, and a pH neutralizer.

[0040] The dosage form of the cosmetics may be, but is not limited to, ointments, aqueous solutions, emulsions, essences and creams.

[0041] Among them, calculated by mass, the matrix of the cosmetic external dosage form includes 70 to 80 parts of water, 0.1 to 1 part of thickener, 1 to 10 parts of moisturizer, 2 to 10 parts of emulsifier, 1 to 15 parts of emollient, 0.1 to 4 parts of antibacterial agent and 0.05 to 1 part of pH neutralizer.

[0042] The water content may be, but is not limited to, 70 parts, 72 parts, 74 parts, 76 parts, 78 parts, or 80 parts.

[0043] The content of the thickener may be, but is not limited to, 0.1 part, 0.3 part, 0.5 part, 0.7 part, 0.8 part, 0.9 part, or 1.0 part. The thickener may be carbomer.

[0044] The content of the moisturizer may be, but not limited to, 1 part, 3 parts, 5 parts, 7 parts, 9 parts, and 10 parts; specifically, the moisturizer includes at least one of betaine and 1,2-hexanediol. More specifically, the moisturizer includes 0.5 to 5 parts of betaine and 0.1 to 5 parts of 1,2-hexanediol, such as betaine may be, but not limited to, 0.5 parts, 1 part, 2 parts, 3 parts, 4 parts, and 5 parts; 1,2-hexanediol may be, but not limited to, 0.1 parts, 0.6 parts, 1.2 parts, 1.8 parts, 2.5 parts, 3.2 parts, 4 parts, 4.5 parts, and 5 parts.

[0045] The content of the emulsifier may be, but is not limited to, 2 parts, 3 parts, 4 parts, 6 parts, 7 parts, 8 parts, 9 parts, or 10 parts; specifically, the emulsifier includes 0.1 to 5 parts Care 165MB and 0.5 to 5 parts of EMULIUM MELLIFERAMB. Care 165MB can be in the form of, but not limited to, 0.1, 1, 2, 3, 4, or 5 copies; EMULIUMMELLIFERA MB can be in the form of, but not limited to, 0.5, 1, 2, 3, 4, or 5 copies.

[0046] The content of the emollient may be, but is not limited to, 1 part, 3 parts, 5 parts, 7 parts, 9 parts, 11 parts, 13 parts, and 15 parts. Specifically, the emollient includes at least one of cetostearyl alcohol, isononyl isononanoate, dimethicone, squalane, and tocopherol acetate. For example, the emollient includes 0.1 to 3 parts of cetostearyl alcohol, 1 to 5 parts of isononyl isononanoate, 1 to 5 parts of dimethicone, 0.1 to 5 parts of squalane, and 0.1 to 2 parts of tocopherol acetate.

[0047] Among them, the content of the antibacterial agent can be but not limited to 0.1 parts, 0.5 parts, 1 parts, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, and 4 parts; for example, the antibacterial agent can be but not limited to p-hydroxyacetophenone.

[0048] The content of the pH neutralizer may be, but is not limited to, 0.05 part, 0.06 part, 0.07 part, 0.08 part, 0.09 part, or 1 part; for example, the pH neutralizer may be, but is not limited to, aminomethyl propanol.

[0049] Specifically, the preparation method of the above cosmetics comprises the following steps:

[0050] (1) mixing water, a thickener, allantoin and a humectant, and heating and stirring to obtain an aqueous phase;

[0051] (2) mixing bisabolol, an emulsifier, and an emollient, and heating and stirring to obtain an oil phase;

[0052] (3) mixing the aqueous phase and the oil phase, performing vacuum insulation, and then performing homogenization;

[0053] (4) cooling the mixture obtained in step (3) to 60-65° C., adding a pH neutralizer and stirring uniformly;

[0054] (5) cooling the mixture obtained in step (4) to 50-55° C., adding an antibacterial agent and o-cymene-5-ol and stirring evenly;

[0055] (6) cooling the mixture obtained in step (5) to below 40° C., adding Shuminjia, quaternary ammonium salt-73, total glycosides of Centella asiatica, niacinamide, Otingmin, and ethoxydiglycol, and stirring evenly;

[0056] (7) Cool the mixture obtained in step (6) to room temperature and fill it.

[0057] Further, step (1) of the present invention comprises heating to 75-80°C;

[0058] Furthermore, step (2) of the present invention comprises heating to 70-75°C.

[0059] Furthermore, in step (3) of the present invention, the vacuum insulation time is 10 to 15 minutes.

[0060] In order to better illustrate the purpose, technical solutions and beneficial effects of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0061] Specifically, the detailed information of the main raw materials used in the embodiments and comparative examples are as follows:

[0062]

[0063]

[0064] Example 1

[0065] This embodiment provides an acne-removing and soothing cream, which comprises, by weight, 0.3 parts of carbomer, 0.5 parts of Care 165MB, 2 parts of EMULIUM MELLIFERAMB, 1 part of isononyl isononanoate, 2 parts of polydimethylsiloxane, 3 parts of cetearyl alcohol, 3 parts of squalane, 0.5 parts of tocopheryl acetate, 0.4 parts of bisabolol, 0.15 parts of allantoin, 0.5 parts of betaine, 0.8 parts of 1,2-hexanediol, 3 parts of niacinamide, 2 parts of sominjia, 0.3 parts of Centella asiatica total glucoside, 2 parts of autingmin, 0.1 parts of p-hydroxyacetophenone, 0.08 parts of o-cymene-5-ol, 5 parts of quaternium-73, 2 parts of ethoxydiglycol, 0.06 parts of aminomethyl propanol, 71.31 parts of water.

[0066] This embodiment also provides a method for preparing an acne-removing and soothing cream, the steps comprising:

[0067] (1) Add water, carbomer, allantoin, betaine, and 1,2-hexanediol into a water phase pot, mix, heat to 80° C., stir for 10 min to obtain a water phase, and then pump the water phase into the main pot;

[0068] (2) Bisabolol, Care 165MB, EMULIUM MELLIFERAMB, isononyl isononanoate, dimethicone, cetearyl alcohol, squalane, and tocopheryl acetate were added to the oil phase pot and mixed, heated to 74°C, and stirred for 5 minutes to obtain the oil phase;

[0069] (3) The oil phase is pumped into the main pot, vacuum-insulated for 13 min, and then homogenized;

[0070] (4) cooling the mixture obtained in step (3) to 62° C., adding aminomethyl propanol and stirring evenly;

[0071] (5) cooling the mixture obtained in step (4) to 52° C., adding p-hydroxyacetophenone and o-cymene-5-ol and stirring evenly;

[0072] (6) cooling the mixture obtained in step (5) to 36° C., adding Shuminjia, quaternary ammonium salt-73, total glycosides of Centella asiatica, niacinamide, Otingmin, and ethoxydiglycol, and stirring evenly;

[0073] (7) The mixture obtained in step (6) is cooled to room temperature, the material is left to stand for 24 hours, and the material is taken out and filled after being tested and qualified.

[0074] Example 2

[0075] This embodiment provides an acne-removing and soothing cream, which comprises, by weight, 0.15 parts of carbomer, 0.3 parts of Care 165MB, 1.5 parts of EMULIUM MELLIFERA MB, 0.5 parts of isononyl isononanoate, 1.5 parts of polydimethylsiloxane, 2.5 parts of cetearyl alcohol, 2 parts of squalane, 0.3 parts of tocopheryl acetate, 0.3 parts of bisabolol, 0.1 parts of allantoin, 0.3 parts of betaine, 0.5 parts of 1,2-hexanediol, 2 parts of niacinamide, 1 part of sominjia, 0.25 parts of Centella asiatica total glucoside, 1.8 parts of autinmin, 0.1 parts of p-hydroxyacetophenone, 0.05 parts of o-cymene-5-ol, 4 parts of quaternium-73, 1 part of ethoxydiglycol, 0.07 parts of aminomethyl propanol, and 79.78 parts of water.

[0076] This embodiment also provides a method for preparing an acne-removing and soothing cream, the steps comprising:

[0077] (1) Add water, carbomer, allantoin, betaine, and 1,2-hexanediol into a water phase pot, mix, heat to 77° C., stir for 8 minutes to obtain a water phase, and then pump the water phase into the main pot;

[0078] (2) Bisabolol, Care 165MB, EMULIUM MELLIFERA MB, isononyl isononanoate, dimethicone, cetearyl alcohol, squalane, and tocopheryl acetate were added to the oil phase pot and mixed, heated to 72°C, and stirred for 5 minutes to obtain the oil phase;

[0079] (3) The oil phase is pumped into the main pot, vacuum-insulated for 15 min, and then homogenized;

[0080] (4) cooling the mixture obtained in step (3) to 64° C., adding aminomethyl propanol and stirring evenly;

[0081] (5) cooling the mixture obtained in step (4) to 54° C., adding p-hydroxyacetophenone and o-cymene-5-ol and stirring evenly;

[0082] (6) cooling the mixture obtained in step (5) to 38° C., adding Shuminjia, quaternary ammonium salt-73, total glycosides of Centella asiatica, niacinamide, Otingmin, and ethoxydiglycol, and stirring evenly;

[0083] (7) The mixture obtained in step (6) is cooled to room temperature, the material is left to stand for 24 hours, and the material is taken out and filled after being tested and qualified.

[0084] Example 3

[0085] This embodiment provides an acne-removing and soothing cream, which comprises, by weight, 0.3 parts of carbomer, 0.4 parts of Care 165MB, 3 parts of EMULIUM MELLIFERA MB, 0.8 parts of isononyl isononanoate, 1.8 parts of polydimethylsiloxane, 3 parts of cetearyl alcohol, 3 parts of squalane, 0.7 parts of tocopheryl acetate, 0.4 parts of bisabolol, 0.15 parts of allantoin, 0.5 parts of betaine, 0.7 parts of 1,2-hexanediol, 2.5 parts of niacinamide, 1.5 parts of sominjia, 0.3 parts of Centella asiatica total glucoside, 2 parts of autingmin, 0.1 parts of p-hydroxyacetophenone, 0.06 parts of o-cymene-5-ol, 3 parts of quaternium-73, 1.5 parts of ethoxydiglycol, 0.09 parts of aminomethyl propanol, and 74.2 parts of water.

[0086] This embodiment also provides a method for preparing an acne-removing and soothing cream, the steps comprising:

[0087] (1) Add water, carbomer, allantoin, betaine, and 1,2-hexanediol into a water phase pot, mix, heat to 76°C, stir for 6 minutes to obtain a water phase, and then pump the water phase into the main pot;

[0088] (2) Bisabolol, Care 165MB, EMULIUM MELLIFERA MB, isononyl isononanoate, dimethicone, cetearyl alcohol, squalane, and tocopheryl acetate were added to the oil phase pot and mixed, heated to 71°C, and stirred for 7 minutes to obtain the oil phase;

[0089] (3) The oil phase is pumped into the main pot, vacuum-insulated for 11 min, and then homogenized;

[0090] (4) cooling the mixture obtained in step (3) to 62° C., adding aminomethyl propanol and stirring evenly;

[0091] (5) cooling the mixture obtained in step (4) to 51° C., adding p-hydroxyacetophenone and o-cymene-5-ol and stirring evenly;

[0092] (6) cooling the mixture obtained in step (5) to 30° C., adding Shuminjia, quaternary ammonium salt-73, total glycosides of Centella asiatica, niacinamide, Otingmin, and ethoxydiglycol, and stirring evenly;

[0093] (7) The mixture obtained in step (6) is cooled to room temperature, the material is left to stand for 24 hours, and the material is taken out and filled after being tested and qualified.

[0094] Comparative Example 1

[0095] The difference between this comparative example and Example 1 is that allantoin is removed, and the rest is the same as Example 1.

[0096] Comparative Example 2

[0097] The difference between this comparative example and Example 1 is that nicotinamide is removed, and the rest is the same as Example 1.

[0098] Comparative Example 3

[0099] The difference between this comparative example and Example 1 is that Shuminjia is removed, and the rest is the same as Example 1.

[0100] Comparative Example 4

[0101] The difference between this comparative example and Example 1 is that the total glycosides of Centella asiatica are removed, and the rest is the same as Example 1.

[0102] Comparative Example 5

[0103] The difference between this comparative example and Example 1 is that Aotingmin is removed, and the rest is the same as Example 1.

[0104] Comparative Example 6

[0105] This comparative example is the same as Example 1 except that o-cymene-5-ol is removed.

[0106] Comparative Example 7

[0107] This comparative example is the same as Example 1 except that Quaternium-73 is removed.

[0108] Comparative Example 8

[0109] This comparative example is the same as Example 1 except that bisabolol is removed.

[0110] Comparative Example 9

[0111] This comparative example is the same as Example 1 except that ethoxydiglycol is removed.

[0112] Refer to the "Disinfection Technical Specifications" (2002 edition) to conduct a 24-hour antibacterial test on the acne-relieving and soothing creams of Examples 1 to 3 and Comparative Examples 1 to 9 to test the inhibitory effect on bacteria. The results are shown in Table 1.

[0113] The red blood cell hemolysis experiment (RBC) is one of the alternative methods for the rabbit eye irritation experiment. The basic principle is to evaluate the damage of chemicals to eye tissue cells by measuring the amount of hemoglobin released from cells and the degree of denaturation. The RBC experiment can be used to evaluate the eye irritation of cosmetics. Therefore, in order to evaluate the sensitivity of the acne-relieving and soothing creams of Examples 1 to 3 and Comparative Examples 1 to 9, the red blood cell hemolysis experiment was also conducted on the acne-relieving and soothing creams of Examples 1 to 3 and Comparative Examples 1 to 9. The results are shown in Table 2; this experiment uses the RBC experiment test method and judgment criteria of the European Alternative Methods Validation Center. The specific judgment criteria are as follows: L / D > 100 indicates no irritation, 10 < L / D ≤ 100 indicates slight irritation, 1 < L / D ≤ 10 indicates mild irritation, 0.1 < L / D ≤ 1 indicates moderate irritation, and L / D ≤ 0.1 indicates severe irritation; where HD50 is the sample concentration when 50% of red blood cells are hemolyzed, DI is the protein denaturation index, and L / D is the ratio of HD50 to DI.

[0114] Refer to the following method to conduct a human efficacy test on the acne-relieving and soothing creams of Examples 1 to 3 and Comparative Examples 1 to 9.

[0115] Experimental subjects: There were 260 subjects, volunteer youths with obvious acne, red dots, etc. on the face, regardless of gender, aged 29 - 35 years old. 20 people were randomly selected as a group, and a total of 13 groups were divided.

[0116] Test method: ① After washing their faces, one group of subjects used ordinary skin care products on their faces twice a day, serving as a blank control group; ② After washing their faces, the other 12 groups of subjects used one of the acne-removing and soothing creams in Examples 1 to 3 and Comparative Examples 1 to 9 on their faces twice a day; both of the above ① and ② were required to use the selected products continuously for a total of 30 days. During this period, all participants were required to record the effectiveness of their skin at three time points: the 7th day, the 14th day, and the 30th day. The results are shown in Table 3.

[0117] In order to reflect the users' true feelings and satisfaction with the product effects, a detailed evaluation survey was conducted on the product on the 30th day. The evaluation items included five items, and each item was scored on a 10-point scale. The five items are: acne redness and swelling are reduced, to evaluate whether the acne has been relieved; acne redness and swelling subside, to evaluate the gradual subsidence of acne redness and swelling and the speed of subsidence; less oily skin, to evaluate the improvement of skin oil secretion; partial disappearance of acne, to evaluate how many acnes have completely disappeared; most of the acne has disappeared, to evaluate the significant reduction in the number of acne. The scoring standard is divided into four levels: 1 to 3 points indicate poor effect, that is, almost no improvement is observed; 4 to 5 points indicate average effect, that is, there is some improvement but not significant; 6 to 7 points indicate good effect, that is, the improvement can be clearly felt; 8 to 10 points indicate the best effect, that is, not only there is a significant improvement but also the expected optimal state is achieved. The product evaluation adjustment table is shown in Table 4.

[0118] Table 1 Antibacterial test results

[0119]

[0120] Table 2 Sensitivity test results

[0121] sample L / D Grading Example 1 221 Non-irritating Example 2 195 Non-irritating Example 3 204 Non-irritating Comparative Example 1 50 Slightly irritating Comparative Example 2 152 Non-irritating Comparative Example 3 95 Slightly irritating Comparative Example 4 80 Slightly irritating Comparative Example 5 85 Slightly irritating Comparative Example 6 160 Non-irritating Comparative Example 7 168 Non-irritating Comparative Example 8 90 Slightly irritating Comparative Example 9 170 Non-irritating

[0122] Table 3 Trial status table

[0123]

[0124] Table 4 Product evaluation adjustment table

[0125]

[0126] As can be seen from Table 1, the anti-acne soothing creams obtained in Examples 1 to 3 have high inhibition rates on Escherichia coli, Propionibacterium acnes, Staphylococcus aureus, and Candida albicans, while the inhibition rates of Comparative Examples 1 to 5 and Comparative Examples 8 to 9 are all reduced, and the inhibition rates of the anti-acne soothing creams in Comparative Examples 6 and 7 are greatly reduced, which indicates that the mutual cooperation between the nine components in the anti-acne soothing composition has a synergistic effect in terms of antibacterial effect.

[0127] It can be seen from Table 2 that the irritation of the acne soothing cream obtained in Examples 1 to 3 is classified as non-irritating, while the irritation of the acne soothing cream prepared in Comparisons 1, 3, 4, 5, and 8 is classified as slightly irritating, which indicates that the combination of Shuminjia, bisabolol, allantoin, Centella asiatica glycosides, and Otingmin can produce significant synergistic effects in soothing and repairing, and can effectively alleviate skin sensitivity and external irritation reactions caused by quaternary ammonium salt-73 and o-cymene-5-ol.

[0128] According to the trial investigation results in Table 3, compared with the blank sample, the acne-removing and soothing creams of Examples 1 to 3 began to show effects on the 7th day of use, and the effects became more significant as the use time increased; on the contrary, the acne-removing and soothing creams of Comparative Examples 1 to 9 not only had a longer effective period, but their use effects were also significantly inferior to the acne-removing and soothing cream of the present invention.

[0129] It can be seen from the product evaluation questionnaire in Table 4 that the users who used the acne soothing cream prepared in Examples 1 to 3 of the present invention can obviously achieve the effects of acne soothing and repairing the skin barrier, and the survey scores are higher than those of the acne soothing cream prepared in Comparative Examples 1 to 9. In particular, when the two ingredients of o-cymene-5-ol and pionin are not added (such as Comparative Examples 6 and 7), the use effect of the acne soothing cream prepared is obviously the worst.

[0130] In summary, the various components in the acne-removing and soothing composition of the present invention cooperate with each other and work synergistically to achieve the effect of acne-removing and soothing. Long-term use can regulate and repair damaged skin barriers.

[0131] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the present invention.

Claims

1. An acne-removing and soothing composition, characterized in that: Including quaternary ammonium salt-73, Shuminjia, Centella asiatica total glucoside, allantoin, niacinamide, o-cymene-5-ol, bisabolol, Otingmin, and ethoxydiglycol.

2. The acne-removing and soothing composition according to claim 1, characterized in that: Calculated by mass, it includes 1 to 10 parts of quaternary ammonium salt-73, 1 to 5 parts of sominjia, 0.1 to 0.5 parts of total Centella asiatica glucosides, 0.1 to 1.0 parts of allantoin, 1 to 5 parts of niacinamide, 0.01 to 0.1 parts of o-cymene-5-ol, 0.1 to 1 parts of bisabolol, 1 to 5 parts of autinamine, and 1 to 5 parts of ethoxydiglycol.

3. A cosmetic, characterized in that: The cosmetic external dosage form comprises a matrix, and also comprises the anti-acne soothing composition according to any one of claims 1 to 2, wherein the matrix comprises water, a thickener, a moisturizer, an emulsifier, an antibacterial agent, an emollient and a pH neutralizer.

4. The cosmetic according to claim 3, characterized in that The dosage form of the cosmetic is at least one of a paste, an aqueous solution, an emulsion, an essence and a cream.

5. The cosmetic according to claim 3, characterized in that: The cosmetic external dosage form matrix comprises, by weight, 70 to 80 parts of water, 0.1 to 1 part of a thickener, 1 to 10 parts of a moisturizer, 2 to 10 parts of an emulsifier, 1 to 15 parts of an emollient, 0.1 to 4 parts of an antibacterial agent, and 0.05 to 1 part of a pH neutralizer.

6. The cosmetic according to claim 3, characterized in that The humectant includes at least one of betaine and 1,2-hexanediol.

7. The cosmetic according to claim 3, characterized in that The emulsifier includes At least one of Care 165MB and EMULIUM MELLIFERA MB.

8. The cosmetic according to claim 3, characterized in that: The emollient includes at least one of cetearyl alcohol, isononyl isononanoate, dimethicone, squalane and tocopheryl acetate.

9. The method for preparing a cosmetic according to any one of claims 3 to 8, characterized in that the steps include: (1) mixing water, a thickener, allantoin and a humectant, and heating and stirring to obtain an aqueous phase; (2) mixing bisabolol, an emulsifier, and an emollient, and heating and stirring to obtain an oil phase; (3) mixing the aqueous phase and the oil phase, performing vacuum insulation, and then performing homogenization; (4) cooling the mixture obtained in step (3) to 60-65° C., adding a pH neutralizer and stirring uniformly; (5) cooling the mixture obtained in step (4) to 50-55° C., adding an antibacterial agent and o-cymene-5-ol and stirring evenly; (6) cooling the mixture obtained in step (5) to below 40° C., adding Shuminjia, quaternary ammonium salt-73, total glycosides of Centella asiatica, niacinamide, Otingmin, and ethoxydiglycol, and stirring evenly; (7) Cool the mixture obtained in step (6) to room temperature and fill it.

10. The method for preparing a cosmetic according to claim 9, characterized in that: Step (1) comprises heating to 75-80°C; step (2) comprises heating to 70-75°C.

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