Clindamycin phosphate processing and hydrolyzing device and method thereof

Abstract

The invention discloses a clindamycin phosphate processing hydrolysis device and method, and particularly relates to the technical field of injection preparation, the clindamycin phosphate processing hydrolysis device comprises a supporting frame, a hydrolysis mixing assembly is arranged on the supporting frame, the hydrolysis mixing assembly comprises a sliding seat arranged on the supporting frame, the sliding seat is in sliding connection with the supporting frame, and a hydrolysis cylinder is arranged at the bottom of the sliding seat. Clindamycin phosphate powder is prevented from being stacked together due to friction force, the amplitude plate and the heating plate can generate high-frequency amplitude, raw liquid clindamycin phosphate powder molecules can be fully mixed together easily, meanwhile, the temperature of the raw liquid clindamycin phosphate powder during evolutionary hydrolysis can be controlled through the heating plate, and therefore the raw liquid clindamycin phosphate powder can be obtained. Compressed airflow is conveyed into the aeration pipe, is aerated in the hydrolysis cylinder through the aeration pipe, and is stirred by matching with the rotation of the connecting disc, the filter screen plate, the first stirring blade and the second stirring blade, so that the caking of a stock solution and lindamycin phosphate powder can be effectively avoided, and the hydrolysis quality and effect are ensured.

Description

Technical Field

[0001] The invention relates to the technical field of injection preparation, and more specifically to a clindamycin phosphate processing and hydrolysis device and a method thereof. Background Art

[0002] Clindamycin phosphate is an organic compound and also an antibiotic drug. It is a semi-synthetic derivative of clindamycin. Clindamycin phosphate has no antibacterial activity in vitro, but it is rapidly hydrolyzed into clindamycin after entering the body and shows its pharmacological activity. Therefore, its antibacterial spectrum, antibacterial activity and therapeutic effect are the same as clindamycin, but its fat solubility and permeability are better than clindamycin. Clindamycin phosphate itself is inactive in vitro and needs to release clindamycin through hydrolysis reaction to exert its antibacterial effect. The hydrolysis process is the key step in its transformation from an inactive form to an active form.

[0003] Among them, the patent with announcement number CN219816053U discloses a device for preparing clindamycin phosphate injection, which relates to the technical field of preparing clindamycin phosphate injection, and comprises a fixed seat for supporting the preparation device, a pillar is provided on the top of the fixed seat near the length direction, a connecting frame is provided on the outer wall of the pillar, a processing mechanism is fixedly connected inside the connecting frame, a filtering mechanism is provided on the top of the fixed seat and the bottom facing the processing mechanism, a filtering plate is movably provided inside the filtering mechanism, a mounting mechanism is clamped on the top of the filtering plate, a lifting power mechanism is provided on the top of the pillar, a stirring mechanism is movably provided inside the processing mechanism, and the lifting power mechanism is movably connected to the stirring mechanism; When the structure is in use, the clindamycin phosphate injection preparation device can be used to conveniently stir up and down, thereby improving the stirring efficiency, and the filter screen is easy to clean. However, when the raw materials are hydrolyzed and mixed, the raw materials are prone to agglomeration, which affects the hydrolysis effect. Summary of the invention

[0004] In order to overcome the above-mentioned defects of the prior art, the present invention provides a clindamycin phosphate processing and hydrolysis device and method thereof, aiming to solve the problems raised in the above-mentioned background technology.

[0005] The present invention provides the following technical solution: a clindamycin phosphate processing and hydrolysis device, comprising a support frame, on which a hydrolysis mixing assembly is arranged; The hydrolysis mixing assembly comprises a slide seat arranged on a support frame, the slide seat is slidably connected to the support frame, and a hydrolysis cylinder is arranged at the bottom of the slide seat; A sealing cylinder is embedded in the hydrolysis cylinder, a plurality of connecting rings are sleeved on the surface of the sealing cylinder, and an elastic supporting column is clamped on each of the connecting rings, an amplitude plate is arranged on each of the elastic supporting columns, and a heating plate is arranged on the outer side of each of the connecting rings; The top of the hydrolysis cylinder is clamped with a limiting cylinder, a rotating shaft is rotatably connected in the limiting cylinder, a connecting disk is fixedly arranged at the bottom of the rotating shaft, a plurality of filter plates for separation and treatment are distributed on the connecting disk, a plurality of first stirring blades are distributed on the top of the connecting disk, a plurality of second stirring blades are distributed on the bottom of the connecting disk, and a dislocation opening is formed between each two adjacent first stirring blades and second stirring blades; It can be seen that in the above technical solution, when the filter plate rotates, it is easy to filter out impurities in the powder during hydrolysis, and the first stirring blade and the second stirring blade facilitate the stock solution and the lincomycin phosphate powder to be fully mixed together for hydrolysis. The amplitude generated by starting the vibration motor is transmitted to the connecting ring and is expanded through the elastic support column, so that the amplitude plate and the heating plate can generate high-frequency amplitude, which is easy for the stock solution and the lincomycin phosphate powder molecules to be fully mixed together. At the same time, the temperature during hydrolysis can be controlled by the heating plate, and it is aerated in the hydrolysis cylinder through the aeration pipe, and then the connecting plate, the filter plate, the first stirring blade and the second stirring blade are rotated to stir it, which can effectively avoid the stock solution and the lincomycin phosphate powder from caking, thereby ensuring the quality of hydrolysis. Optionally, in a possible implementation manner, one end of the sealing cylinder passes through the hydrolysis cylinder and extends to the surface of the hydrolysis cylinder, a vibration motor is installed inside the sealing cylinder by bolts, an air pump is provided on one side of the vibration motor, the air pump is installed in the sealing cylinder by bolts, an aeration pipe is provided at the output end of the air pump, the aeration pipe passes through the sealing cylinder and extends to the outside of the sealing cylinder, a support seat is provided at the top of the hydrolysis cylinder, a conveying cylinder connected to the hydrolysis cylinder is plugged on the support seat, a docking sleeve is rotatably connected to the top of the conveying cylinder, a spreader is fixedly provided on the top of the docking sleeve, a plurality of material distribution ports are opened through the spreader, a feed hopper is rotatably connected to the top of the spreader, a valve is embedded in the feed hopper, a driving motor is installed on the top of the slide seat by bolts, a pulley is provided at the output end of the driving motor and one end of the top rotating shaft of the limit cylinder, the two pulleys are respectively located on both sides of the spreader, the pulley and the outside of the spreader are both connected with belts, and a screw transmission module for driving the slide seat to move up and down is provided on the slide seat; It can be seen that in the above technical solution, clindamycin phosphate is diverted by the valve, and the pulley drives the spreader to rotate via the belt, so that each distribution port can rotate, and the clindamycin phosphate after diversion by the valve is easily screened out and conveyed to the conveying cylinder when the distribution port rotates, thereby avoiding the clindamycin phosphate powder from piling up due to friction.

[0006] A method, using the above-mentioned clindamycin phosphate processing and hydrolysis device, is characterized in that it comprises the following steps: Step 1: The staff installs the device at the designated location. When processing and hydrolyzing clindamycin phosphate, the stock solution is injected into the hydrolysis cylinder, and the clindamycin phosphate is injected into the feed hopper at the same time. The clindamycin phosphate is diverted through the valve; Step 2, simultaneously starting the drive motor, the output end of the drive motor drives the pulley to rotate the spreader via the belt, so that each feed opening can rotate, and the clindamycin phosphate after being shunted by the valve is easily sieved out and conveyed to the conveying cylinder when the feed opening rotates, thereby preventing the clindamycin phosphate powder from piling up due to friction; Step 3: when the lincomycin phosphate powder is transported to the conveying cylinder, it is guided to the hydrolysis cylinder through the conveying cylinder for hydrolysis. At the same time, when the belt rotates, the pulley at the top of the rotating shaft can also drive the rotating shaft to rotate, thereby rotating the connecting disk and the filter plate. When the filter plate rotates, it is easy to filter impurities in the powder during hydrolysis, and the first stirring blade and the second stirring blade facilitate the stock solution and the lincomycin phosphate powder to be fully mixed together for hydrolysis; Step 4: When the stock solution and the lincomycin phosphate powder are hydrolyzed and mixed in the hydrolysis cylinder, the amplitude generated by starting the vibration motor is transmitted to the connecting ring and expanded through the elastic support column, so that the amplitude plate and the heating plate can generate high-frequency amplitude, which is easy for the stock solution and the lincomycin phosphate powder molecules to be fully mixed together, and the temperature during the hydrolysis can be controlled by the heating plate; Step 5. In order to ensure the efficiency and effect of hydrolysis, the compressed air flow is delivered to the aeration pipe through the air pump, aerated in the hydrolysis cylinder through the aeration pipe, and then the connecting plate, the filter plate, the first stirring blade and the second stirring blade are rotated to stir it, which can effectively avoid the agglomeration of the stock solution and the lincomycin phosphate powder and ensure the quality of hydrolysis.

[0007] Technical effects and advantages of the present invention: 1. The clindamycin phosphate of the present invention is shunted by a valve, and each feed opening can rotate, so that the clindamycin phosphate after the valve shunting is easily sieved out and transported to the conveying cylinder when the feed opening rotates, thereby preventing the clindamycin phosphate powder from piling up due to friction; 2. The amplitude generated by the start-up of the vibration motor of the present invention is transmitted to the connecting ring and amplified by the elastic support column, so that the amplitude plate and the heating plate can generate high-frequency amplitude, which is easy for the stock solution and the lincomycin phosphate powder molecules to be fully mixed together, and the temperature during the evolution and hydrolysis can be controlled by the heating plate; 3. The present invention rotates the connecting disk and the filter plate, and the filter plate is easy to filter impurities in the powder during hydrolysis when rotating, while the first stirring blade and the second stirring blade facilitate the stock solution and the lincomycin phosphate powder to be fully mixed together for hydrolysis; 4. In order to ensure the efficiency and effect of hydrolysis, the present invention delivers compressed air to the aeration pipe through the air pump, aerates it in the hydrolysis cylinder through the aeration pipe, and then rotates and stirs it with the connection plate, the filter plate, the first stirring blade and the second stirring blade, which can effectively avoid the agglomeration of the stock solution and the lincomycin phosphate powder, thereby ensuring the quality of hydrolysis; In summary, through the corresponding coordinated use of various structures, the clindamycin phosphate after the valve diversion is sifted out through the distribution port during rotation and conveyed to the conveying cylinder, so that the clindamycin phosphate powder is prevented from piling up due to friction. The amplitude plate and the heating plate can generate high-frequency amplitude, which is easy for the original liquid clindamycin phosphate powder molecules to be fully mixed together. At the same time, the temperature of the original liquid clindamycin phosphate powder can be controlled by the heating plate during hydrolysis. The compressed air flow is conveyed to the aeration pipe, and aerated in the hydrolysis cylinder through the aeration pipe. Then, the connecting plate, the filter plate, the first stirring blade and the second stirring blade are rotated to stir the original liquid and the clindamycin phosphate powder, which can effectively prevent the original liquid and the clindamycin phosphate powder from agglomerating, thereby ensuring the quality and effect of the hydrolysis. BRIEF DESCRIPTION OF THE DRAWINGS

[0008] In order to more clearly illustrate the technical solutions in the present disclosure, the following briefly introduces the drawings required for use in some embodiments. Obviously, the drawings described below are only drawings of some embodiments of the present disclosure. For those of ordinary skill in the art, other drawings can also be obtained based on these drawings. In addition, the drawings described below can be regarded as schematic diagrams, and are not intended to limit the actual size of the product involved in the embodiments of the present disclosure, the actual process of the method, the actual timing of the signal, etc.

[0009] Figure 1 It is the front view of the overall structure of the present invention.

[0010] Figure 2 It is a side view of the overall structure of the present invention.

[0011] Figure 3 It is a stereoscopic diagram of the hydrolysis cylinder, the conveying cylinder, the spreader, the feed hopper and the valve of the present invention.

[0012] Figure 4 For the present invention Figure 3 Exploded diagram.

[0013] Figure 5 It is a stereoscopic diagram of the sealing cylinder, the connecting ring, the elastic supporting column, the amplitude plate and the heating plate of the present invention.

[0014] Figure 6 It is a stereoscopic diagram of the slide seat, the limiting cylinder, the rotating shaft, the connecting plate and the filter plate of the present invention.

[0015] Figure 7 It is a stereoscopic diagram of the support frame and the screw drive module of the present invention.

[0016] The accompanying drawings are marked as follows: 1. support frame; 2. slide seat; 3. hydrolysis cylinder; 4. sealing cylinder; 5. connecting ring; 6. elastic support column; 7. amplitude plate; 8. heating plate; 9. limit cylinder; 10. rotating shaft; 11. connecting plate; 12. filter plate; 13. first stirring blade; 14. second stirring blade; 15. vibration motor; 16. air pump; 17. support seat; 18. conveying cylinder; 19. docking sleeve; 20. spreader; 21. material distribution port; 22. feed hopper; 23. valve; 24. aeration pipe; 25. drive motor; 26. pulley; 27. belt; 28. screw transmission module. DETAILED DESCRIPTION

[0017] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0018] As attached Figure 1 - Figure 7 The clindamycin phosphate processing and hydrolysis device shown in the invention has a hydrolysis mixing assembly arranged on the support frame 1, and the clindamycin phosphate after being shunted by the valve 23 is screened out and transported to the conveying cylinder 18 when rotating through the material distribution port 21, so as to avoid the clindamycin phosphate powder from piling up due to the friction force, and the amplitude plate 7 and the heating plate 8 can generate high-frequency amplitude, so that the stock solution and the lindamycin phosphate powder molecules can be fully mixed together, and the temperature during the evolutionary hydrolysis can be controlled by the heating plate 8 at the same time, and the compressed air flow is transported to the aeration pipe 24, and aerated in the hydrolysis cylinder 3 through the aeration pipe 24, and then the connecting plate 11, the filter plate 12, the first stirring blade 13 and the second stirring blade 14 are rotated to stir the stock solution, so as to effectively avoid the phenomenon of agglomeration of the stock solution and the lindamycin phosphate powder, and ensure the quality and effect of the hydrolysis, and the specific structure of the assembly is arranged as follows; The hydrolysis mixing assembly comprises a slide 2 arranged on a support frame 1, the slide 2 is slidably connected to the support frame 1, and a hydrolysis cylinder 3 is arranged at the bottom of the slide 2; A sealing cylinder 4 is embedded inside the hydrolysis cylinder 3, and a plurality of connecting rings 5 ​​are sleeved on the surface of the sealing cylinder 4, and each connecting ring 5 is clamped with an elastic support column 6, and an amplitude plate 7 is arranged on each of the elastic support columns 6, and a heating plate 8 is arranged on the outer side of each connecting ring 5; The top of the hydrolysis cylinder 3 is clamped with a limiting cylinder 9, and a rotating shaft 10 is rotatably connected in the limiting cylinder 9. A connecting plate 11 is fixedly arranged at the bottom of the rotating shaft 10, and a plurality of filter plates 12 for separation treatment are distributed on the connecting plate 11. A plurality of first stirring blades 13 are distributed on the top of the connecting plate 11, and a plurality of second stirring blades 14 are distributed on the bottom of the connecting plate 11, and a staggered opening is formed between each adjacent two first stirring blades 13 and second stirring blades 14. One end of the sealing cylinder 4 penetrates the hydrolysis cylinder 3 and extends to the surface of the hydrolysis cylinder 3. A vibration motor 15 is installed inside the sealing cylinder 4 by bolts. An air pump 16 is arranged on one side of the vibration motor 15. The air pump 16 is installed in the sealing cylinder 4 by bolts. An aeration pipe 24 is arranged at the output end of the air pump 16. The aeration pipe 24 penetrates the sealing cylinder 4 and extends to the outside of the sealing cylinder 4. A support seat 17 is arranged on the top of the hydrolysis cylinder 3. A conveying cylinder 18 connected to the hydrolysis cylinder 3 is plugged on the support seat 17. The top of the conveying cylinder 18 is rotatably connected to a docking sleeve 19. The top of the docking sleeve 19 is fixed. A material spreader 20 is provided, and a plurality of material distribution ports 21 are provided on the material spreader 20. A feed hopper 22 is rotatably connected to the top of the material spreader 20, and a valve 23 is embedded in the feed hopper 22. A driving motor 25 is installed on the top of the slide 2 by bolts. A pulley 26 is provided at the output end of the driving motor 25 and one end of the top rotating shaft 10 of the limiting cylinder 9. The two pulleys 26 are respectively located on both sides of the material spreader 20. The pulleys 26 and the outer sides of the material spreader 20 are both connected to the belt 27. A screw transmission module 28 for driving the slide 2 to move up and down is provided on the slide 2. A method, using the above-mentioned clindamycin phosphate processing and hydrolysis device, comprises the following steps: Step 1, the staff installs the device at the designated position, and when processing and hydrolyzing clindamycin phosphate, the stock solution is injected into the hydrolysis cylinder 3, and the clindamycin phosphate is injected into the feed hopper 22 at the same time, and the clindamycin phosphate is diverted through the valve 23; Step 2, simultaneously starting by driving motor 25, the output end of driving motor 25 drives pulley 26 to drive spreader 20 to rotate via belt 27, so that each feed opening 21 can rotate, and clindamycin phosphate after being shunted by valve 23 is easily sieved out and conveyed to conveying cylinder 18 when passing through feed opening 21 rotation, so as to avoid clindamycin phosphate powder from piling up due to friction; Step 3: when the lincomycin phosphate powder is transported to the conveying cylinder 18, it is guided to the hydrolysis cylinder 3 through the conveying cylinder 18 for hydrolysis. At the same time, when the belt 27 rotates, the pulley 26 at the top of the rotating shaft 10 can also rotate to drive the rotating shaft 10 to rotate, thereby rotating the connecting disk 11 and the filter plate 12. When the filter plate 12 rotates, it is easy to filter the impurities in the powder during hydrolysis, and the first stirring blade 13 and the second stirring blade 14 facilitate the stock solution and the lincomycin phosphate powder to be fully mixed together for hydrolysis; Step 4: When the stock solution and the lincomycin phosphate powder are hydrolyzed and mixed in the hydrolysis cylinder 3, the amplitude generated by starting the vibration motor 15 is transmitted to the connecting ring 5, and is expanded through the elastic support column 6, so that the amplitude plate 7 and the heating plate 8 can generate high-frequency amplitude, which is easy for the stock solution and the lincomycin phosphate powder molecules to be fully mixed together, and the temperature during the evolutionary hydrolysis can be controlled by the heating plate 8; Step 5, in order to ensure the efficiency and effect of hydrolysis, the compressed air flow is delivered to the aeration pipe 24 through the air pump 16, aerated in the hydrolysis cylinder 3 through the aeration pipe 24, and then the connecting plate 11, the filter plate 12, the first stirring blade 13 and the second stirring blade 14 are rotated to stir the stock solution and the lincomycin phosphate powder, which can effectively avoid the agglomeration of the stock solution and the lincomycin phosphate powder, thereby ensuring the quality of hydrolysis.

[0019] According to the above structure, when in use, the stock solution is injected into the hydrolysis cylinder 3, and the clindamycin phosphate is injected into the feed hopper 22 at the same time. The clindamycin phosphate is divided through the valve 23, and each of the feed ports 21 can rotate, so that the clindamycin phosphate after the valve 23 is easily divided is sieved out through the feed port 21 when the valve 23 rotates and is transported to the conveying cylinder 18. When the lindamycin phosphate powder is transported to the conveying cylinder 18, it is guided to the hydrolysis cylinder 3 through the conveying cylinder 18 for hydrolysis. When the filter plate 12 rotates, it is easy to filter the impurities in the powder during hydrolysis, and the first stirring blade 13 and the second stirring blade 14 are easily stirred. It is convenient for the stock solution and the lincomycin phosphate powder to be fully mixed together for hydrolysis. The amplitude generated by the start-up of the vibration motor 15 is transmitted to the connecting ring 5, and is amplified through the elastic support column 6, so that the amplitude plate 7 and the heating plate 8 can generate high-frequency amplitude. At the same time, the temperature during the evolutionary hydrolysis can be controlled through the heating plate 8. The compressed air flow is transported to the aeration pipe 24 through the air pump 16, and aerated in the hydrolysis cylinder 3 through the aeration pipe 24, and then the connecting plate 11, the filter plate 12, the first stirring blade 13 and the second stirring blade 14 are rotated to stir it to ensure the quality of hydrolysis.

[0020] Different from the prior art, the present application discloses a clindamycin phosphate processing and hydrolysis device. After being diverted by a valve 23, the clindamycin phosphate is screened out through a material distribution port 21 during rotation and transported to a transport cylinder 18, thereby preventing the clindamycin phosphate powder from piling up due to friction. The amplitude plate 7 and the heating plate 8 can generate high-frequency amplitude, which makes it easy for the stock solution and the lindamycin phosphate powder molecules to be fully mixed together. At the same time, the temperature of the stock solution during hydrolysis can be controlled by the heating plate 8. The compressed air flow is transported to an aeration pipe 24, aerated in a hydrolysis cylinder 3 through the aeration pipe 24, and then the connecting plate 11, the filter plate 12, the first stirring blade 13 and the second stirring blade 14 are rotated to stir the stock solution, thereby effectively preventing the stock solution and the lindamycin phosphate powder from agglomerating, thereby ensuring the quality and effect of the hydrolysis.

[0021] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A clindamycin phosphate processing and hydrolysis device, comprising a support frame (1), characterized in that: The support frame (1) is provided with a hydrolysis mixing component; The hydrolysis mixing assembly comprises a slide seat (2) arranged on a support frame (1), and a hydrolysis cylinder (3) is arranged at the bottom of the slide seat (2); A sealing cylinder (4) is embedded in the hydrolysis cylinder (3), a plurality of connecting rings (5) are sleeved on the surface of the sealing cylinder (4), and each of the connecting rings (5) is clamped with an elastic support column (6), and an amplitude plate (7) is arranged on each of the elastic support columns (6), and a heating plate (8) is arranged on the outer side of each of the connecting rings (5); The top of the hydrolysis cylinder (3) is clamped with a limiting cylinder (9), a rotating shaft (10) is rotatably connected inside the limiting cylinder (9), and a connecting disk (11) is fixedly provided at the bottom of the rotating shaft (10).

2. The clindamycin phosphate processing and hydrolysis device according to claim 1, characterized in that: A plurality of filter plates (12) for separation processing are arranged on the connection plate (11), a plurality of first stirring blades (13) are arranged on the top of the connection plate (11), a plurality of second stirring blades (14) are arranged on the bottom of the connection plate (11), and an offset opening is formed between each two adjacent first stirring blades (13) and second stirring blades (14).

3. The clindamycin phosphate processing and hydrolysis device according to claim 1, characterized in that: A vibration motor (15) is installed inside the sealing cylinder (4) via bolts, and an air pump (16) is provided on one side of the vibration motor (15).

4. The clindamycin phosphate processing and hydrolysis device according to claim 3, characterized in that: An aeration pipe (24) is provided at the output end of the air pump (16).

5. The clindamycin phosphate processing and hydrolysis device according to claim 1, characterized in that: A support seat (17) is provided at the top of the hydrolysis cylinder (3), a conveying cylinder (18) is plugged into the support seat (17), and a docking sleeve (19) is rotatably connected to the top of the conveying cylinder (18).

6. The clindamycin phosphate processing and hydrolysis device according to claim 5, characterized in that: A material distributor (20) is fixedly provided on the top of the docking sleeve (19), and a plurality of material distribution openings (21) are formed through the material distributor (20).

7. The clindamycin phosphate processing and hydrolysis device according to claim 6, characterized in that: The top of the material distributor (20) is rotatably connected to a feed hopper (22), and a valve (23) is embedded in the feed hopper (22).

8. The clindamycin phosphate processing and hydrolysis device according to claim 1, characterized in that: A driving motor (25) is provided at the top of the slide seat (2), and a pulley (26) is provided at the output end of the driving motor (25) and one end of the top rotating shaft (10) of the limiting cylinder (9).

9. The clindamycin phosphate processing and hydrolysis device according to claim 8, characterized in that: The outer sides of the pulley (26) and the spreader (20) are both connected to a belt (27) in a transmission manner, and the slide seat (2) is provided with a screw drive module (28) for driving the slide seat (2) to move up and down.

10. A method using the clindamycin phosphate processing and hydrolysis device according to any one of claims 1 to 9, characterized in that: The following steps are included: Step 1, injecting the stock solution into the hydrolysis cylinder (3), and injecting clindamycin phosphate into the feed hopper (22), and the clindamycin phosphate is diverted through the valve (23); Step 2: Each of the material distribution ports (21) is rotatable, so that the clindamycin phosphate after being diverted by the valve (23) is screened out through the material distribution port (21) when it rotates and is transported to the transport cylinder (18); Step 3, when the lincomycin phosphate powder is transported to the transport cylinder (18), it is guided to the hydrolysis cylinder (3) through the transport cylinder (18) for hydrolysis. When the filter plate (12) rotates, it is easy to filter impurities in the powder during hydrolysis, and the first stirring blade (13) and the second stirring blade (14) facilitate the stock solution and the lincomycin phosphate powder to be fully mixed together for hydrolysis; Step 4: The amplitude generated by the start-up of the vibration motor (15) is transmitted to the connecting ring (5), and is amplified through the elastic support column (6), so that the amplitude plate (7) and the heating plate (8) can generate high-frequency amplitude, and at the same time, the temperature during the evolution and hydrolysis can be controlled through the heating plate (8); Step five, the compressed air flow is delivered to the aeration pipe (24) through the air pump (16), aerated in the hydrolysis cylinder (3) through the aeration pipe (24), and then stirred by the connection plate (11), the filter plate (12), the first stirring blade (13) and the second stirring blade (14) to ensure the quality of hydrolysis.

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