Easily-punctured high-leakproofness medicinal thermoplastic elastomer particle and preparation method thereof

Abstract

The invention relates to the technical field of functional polymer materials, in particular to an easy-to-puncture high-leakproofness medicinal thermoplastic elastomer particle and a preparation method thereof. The thermoplastic elastomer particles are prepared from the following raw materials in parts by weight: 20 to 35 parts of styrene-ethylene-butylene-styrene block copolymer, 10 to 15 parts of polyolefin elastomer POE (Polyolefin Elastomer), 4 to 6 parts of polypropylene, 45 to 60 parts of mineral oil, 1.5 to 3 parts of inorganic filler, 0.05 to 0.15 part of antioxidant, 0.05 to 0.15 part of slipping agent and 0.05 to 0.15 part of dispersing agent; according to the thermoplastic elastomer particle disclosed by the invention, the raw material composition and the raw material content are optimized, the prepared thermoplastic elastomer particle not only keeps the original puncture property of isoprene rubber (butyl rubber), but also keeps the original high elasticity, meanwhile, the tear resistance, aging resistance, easy puncture and high leakproofness are improved, the same material can be recycled, and the preparation method is simple and convenient. And the product is green, environment-friendly and carbon-reducing, has no odor and no color change, and meets the safety requirements of food and medicines.

Description

Technical Field

[0001] The invention relates to the technical field of functional polymer materials, in particular to easy-to-puncture high-sealing medicinal thermoplastic elastomer particles and a preparation method thereof. Background Art

[0002] At present, most of the medicinal sealing caps are composed of three parts: inner cap, outer cap and flexible rubber gasket placed between the inner cap and the outer cap. When taking medicine, a plastic needle is used to penetrate the gasket and inner cap, and infusion is achieved after contact with the liquid medicine. Because the gasket and inner cap are thick, they are easy to fall off during the puncture process, which often leads to contamination of the liquid medicine, and the puncture resistance is very large, which is inconvenient to operate and laborious. With the development of new injection molding technology, "two-color injection molding machines" have appeared in the market, and two injection molding machines can simultaneously inject and mold products of two materials at one time. Thermoplastic elastomer medicinal sealing caps include: the shell of the sealing cap and the elastic airtight puncture area part, and the new injection molding technology can be used to inject and mold the medicinal sealing cap at one time. Without the need for a cap assembly machine and a cap assembly sorting machine, the processing cost is low, the production efficiency is high, and the quality is stable. Traditional flexible rubber gaskets are mostly isoprene rubber or butyl rubber, which require complex processing technologies such as vulcanization, cannot be injection molded, and cannot be reused. Thermoplastic elastomer (TPE) particles have the high elasticity, high strength and high resilience of rubber, can be processed by injection molding, are safe, environmentally friendly and non-toxic, have a wide hardness range, are soft to the touch, are weather-resistant, heat-resistant and fatigue-resistant, have excellent processing performance, do not require vulcanization, can be recycled, and are an environmentally friendly and carbon-reducing material of the same material, suitable for elastic and sealed puncture areas.

[0003] However, the thermoplastic elastomer TPE particles currently used still have the following problems:

[0004] 1. Thermoplastic elastomer TPE particles are made by mixing a variety of polymers and host materials. They cannot pass the biological toxicology risk assessment (GB / T16886.5-2017 "Biological Evaluation of Medical Devices Part 5: In Vitro Cytotoxicity Test") and their cytotoxicity is unqualified.

[0005] 2. It is difficult for thermoplastic elastomers to simultaneously meet the following requirements for pharmaceutical sealing covers:

[0006] 1) Puncture force in the puncture area: the average puncture force is required to be less than 70N and the maximum puncture force is required to be less than 75N;

[0007] 2) Dynamic holding force: The dynamic holding force of plastic needles is required to be greater than 5.5N, and the dynamic holding force of metal needles is required to be greater than 1N;

[0008] 3) Dynamic holding force and puncture sealing: A 0.3 kg weight must be loaded and maintained for 4 hours without falling, and the puncture part must not leak;

[0009] 4) Puncture debris: 3 punctures with a plastic needle, 3 punctures with a 16G stainless steel needle, and ≤20 debris with a plastic or metal puncture;

[0010] 5) Sealing of injection point: For the thermoplastic elastomer medicinal sealing cap, use a 0.8mm steel needle to vertically puncture three times at different points in the puncture area. After pulling out the steel needle, place the thermoplastic elastomer medicinal bottle with a fixed volume of injection water between two parallel plates and apply a pressure of 25KPa. No leakage is allowed in the puncture area;

[0011] 6) The medicine bottle should be hung and kept for 2 hours after the plastic needle is inserted. No leakage should be allowed after the plastic needle is pulled out;

[0012] 7) The medicine bottle is hung and punctured 15 times with a plastic needle. There should be no leakage in the puncture area within 90 minutes.

[0013] Based on this, the present invention provides an easy-to-puncture and highly airtight medicinal thermoplastic elastomer particle and a preparation method thereof to solve the above-mentioned technical problems. Summary of the invention

[0014] The object of the present invention is to provide a medicinal thermoplastic elastomer particle with easy puncture and high airtightness and a preparation method thereof. The prepared thermoplastic elastomer particle not only maintains the original punctureability of isoprene rubber (butyl rubber), but also retains the original high elasticity, and at the same time improves the tear resistance, aging resistance, easy puncture, high airtightness, the same material can be recycled, is green, environmentally friendly and reduces carbon emissions, and has no odor and no color change, and meets the safety requirements of food and medicine.

[0015] To achieve the above object, the present invention provides the following technical solutions:

[0016] The first aspect of the present invention provides an easy-to-puncture high-sealing medicinal thermoplastic elastomer particle, which is composed of the following raw materials in parts by weight: 20 to 35 parts of styrene-ethylene-butylene-styrene block copolymer, 10 to 15 parts of polyolefin elastomer POE, 4 to 6 parts of polypropylene, 45 to 60 parts of mineral oil, 1.5 to 3 parts of inorganic filler, 0.05 to 0.15 parts of antioxidant, 0.05 to 0.15 parts of lubricant and 0.05 to 0.15 parts of dispersant.

[0017] The present invention is further configured as follows: the styrene-ethylene-butylene-styrene block copolymer is selected from high molecular weight SEBS, the molecular weight of the high molecular weight SEBS is ≥200,000, and is at least one of G1651, G1652, 6151, 6154, 501T, 502T, 503T, 601, 604, 520, 510, 1320, and 1310.

[0018] The present invention is further configured as follows: the polyolefin elastomer POE is at least one of the food and drug grade brands: 3020, 3588, 6102, 6202, 8999, 8150, 8842, DF610, DF710, LC170, and LC670.

[0019] The present invention is further configured as follows: the polypropylene is selected from low melt index homopolymer polypropylene PP.

[0020] The present invention is further configured as follows: the low melt index homopolymer polypropylene PP is at least one of T30S, 5090T, K8003, M800E, R530, H-T03, and 868K.

[0021] The present invention is further configured as follows: the mineral oil is cycloalkyl mineral oil.

[0022] The present invention is further configured as follows: the cycloalkyl mineral oil is at least one of 4006, 4010, 10-40, and KW26#.

[0023] The present invention is further configured as follows: the inorganic filler is calcium carbonate stone powder with a mesh size of 500 to 1000.

[0024] The present invention is further configured as follows: the antioxidant is compounded by antioxidant 168 and antioxidant 1010 in a mass ratio of 0.65:0.35.

[0025] The present invention is further configured as follows: the lubricant is selected from any one of erucamide, oleamide, and silicone masterbatch.

[0026] The present invention is further configured as follows: the dispersant is stearate.

[0027] The present invention is further configured as follows: the stearate is at least one of zinc stearate, sodium stearate, magnesium stearate, and potassium stearate.

[0028] The second aspect of the present invention also provides a method for preparing the above-mentioned easy-to-puncture high-sealing medicinal thermoplastic elastomer particles, comprising the following steps:

[0029] Step 1: accurately weigh styrene-ethylene-butylene-styrene block copolymer, polyolefin elastomer POE, polypropylene, mineral oil, inorganic filler, antioxidant, lubricant and dispersant for use;

[0030] Step 2: Pour the styrene-ethylene-butylene-styrene block copolymer into a low-speed mixer and heat it to 45° C.

[0031] Step 3, atomize and spray the mineral oil into the styrene-ethylene-butylene-styrene block copolymer in a low-speed mixer at a speed of 5 L / min, stir at a low speed for 30 min, and then stand for 4 h to obtain a uniformly mixed mixture;

[0032] Step 4: Add polyolefin elastomer POE, polypropylene, inorganic filler, antioxidant, lubricant and dispersant to the obtained mixture, and mix in a high-speed mixer for 15 minutes to obtain a uniformly mixed formula;

[0033] Step 5: Extrude the obtained formula material on a twin-screw extruder, and water-cool the pellets to obtain finished thermoplastic elastomer pellets.

[0034] The present invention is further configured as follows: in the step five, the temperatures of the twin-screw extruder are respectively 135-165°C in temperature control zone 1, 175-205°C in temperature control zone 2, 185-215°C in temperature control zone 3, 195-225°C in temperature control zone 4, 190-220°C in temperature control zone 5, 185-215°C in temperature control zone 6, 145-185°C in temperature control zone 7, 145-185°C in temperature control zone 8, 135-165°C in temperature control zone 9, 135-165°C in temperature control zone 10, 185-215°C in screen changing temperature control zone, and 165-195°C in die head temperature control zone; the cooling water temperature of the water-cooled granulation is 35-45°C.

[0035] Compared with the prior art, the present invention has the following beneficial effects:

[0036] In the present invention, styrene-ethylene-butylene-styrene block copolymer, polyolefin elastomer POE, polypropylene, mineral oil, inorganic filler, antioxidant, lubricant and dispersant are used as raw materials to prepare easy-to-puncture high-sealing medicinal thermoplastic elastomer particles. The thermoplastic elastomer particles of the present invention are optimized by comparing the relevant properties of isoprene rubber (butyl rubber) to optimize the raw material composition and raw material content. The prepared thermoplastic elastomer particles not only maintain the original punctureability of isoprene rubber (butyl rubber), but also retain the original high elasticity, while improving the tear resistance, aging resistance, easy puncture, high sealing, the same material can be recycled, green environmental protection and carbon reduction, and no odor and no color change, meet the safety requirements of food and medicine, and can be widely used in food, medicine, medical equipment, electronic appliances, automotive appliances, sporting goods and other fields. DETAILED DESCRIPTION

[0037] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0038] Example 1

[0039] The present embodiment provides an easy-to-puncture high-sealing medicinal thermoplastic elastomer granule, which is composed of the following raw materials in parts by weight: 28 parts of styrene-ethylene-butylene-styrene block copolymer, 12.5 parts of polyolefin elastomer POE, 5 parts of polypropylene, 52 parts of mineral oil, 2.2 parts of inorganic filler, 0.1 parts of antioxidant, 0.1 parts of lubricant and 0.1 parts of dispersant.

[0040] Among them, the styrene-ethylene-butylene-styrene block copolymer uses high molecular weight SEBS.

[0041] Polypropylene uses low melt index homopolymer polypropylene PP.

[0042] The mineral oil used is cycloalkane mineral oil.

[0043] The inorganic filler is 800-mesh calcium carbonate powder.

[0044] The antioxidant is prepared by compounding antioxidant 168 and antioxidant 1010 in a mass ratio of 0.65:0.35.

[0045] The lubricant is erucamide.

[0046] The dispersant is stearate.

[0047] In this embodiment, it should be noted that the styrene-ethylene-butylene-styrene block copolymer uses American Kraton G1651; the polypropylene uses Qilu Petrochemical T30S; the polyolefin elastomer POE uses ExxonMobil 6102; the mineral oil uses PetroChina Karamay Refining and Chemical Cycloalkane White Oil 4010; the inorganic filler uses 800 mesh calcium carbonate from Henan Fuhai Mineral Products Co., Ltd.; the antioxidant uses German BASF antioxidant 168 and antioxidant 1010 in a compound mass ratio of 0.65:0.35; the lubricant uses Jiangxi Zhilian New Materials Co., Ltd.; and the dispersant uses zinc stearate BP7 from Jinan Century Tongda Chemical Co., Ltd.

[0048] In addition, this embodiment also provides a method for preparing the above-mentioned easy-to-puncture high-sealing medicinal thermoplastic elastomer particles, comprising the following steps:

[0049] Step 1: accurately weigh styrene-ethylene-butylene-styrene block copolymer, polyolefin elastomer POE, polypropylene, mineral oil, inorganic filler, antioxidant, lubricant and dispersant for use;

[0050] Step 2: Pour the styrene-ethylene-butylene-styrene block copolymer into a low-speed mixer and heat it to 45° C.

[0051] Step 3, atomize and spray the mineral oil into the styrene-ethylene-butylene-styrene block copolymer in a low-speed mixer at a speed of 5 L / min, stir at a low speed for 30 min, and then stand for 4 h to obtain a uniformly mixed mixture;

[0052] Step 4: Add polyolefin elastomer POE, polypropylene, inorganic filler, antioxidant, lubricant and dispersant to the obtained mixture, and mix in a high-speed mixer for 15 minutes to obtain a uniformly mixed formula;

[0053] Step 5: Extrude the obtained formula material on a twin-screw extruder, and water-cool the pellets to obtain finished thermoplastic elastomer pellets.

[0054] Among them, the temperatures of the twin-screw extruder are 150°C in temperature control zone 1, 190°C in temperature control zone 2, 200°C in temperature control zone 3, 210°C in temperature control zone 4, 205°C in temperature control zone 5, 200°C in temperature control zone 6, 165°C in temperature control zone 7, 165°C in temperature control zone 8, 150°C in temperature control zone 9, 150°C in temperature control zone 10, 200°C in screen changing temperature control zone, and 180°C in die head temperature control zone; the cooling water temperature of the water-cooled granulation is 40°C.

[0055] Example 2

[0056] The preparation method of the easily puncturable and highly airtight medicinal thermoplastic elastomer particles provided in this embodiment is basically the same as that in Example 1, except that: the specific raw material composition and the specific preparation method of the easily puncturable and highly airtight medicinal thermoplastic elastomer particles in this embodiment are different; the specific raw material composition and the specific preparation method of the easily puncturable and highly airtight medicinal thermoplastic elastomer particles in this embodiment are as follows:

[0057] The present embodiment provides an easy-to-puncture high-sealing medicinal thermoplastic elastomer granule, which is composed of the following raw materials in parts by weight: 35 parts of styrene-ethylene-butylene-styrene block copolymer, 15 parts of polyolefin elastomer POE, 6 parts of polypropylene, 60 parts of mineral oil, 3 parts of inorganic filler, 0.15 parts of antioxidant, 0.15 parts of lubricant and 0.15 parts of dispersant.

[0058] Among them, the styrene-ethylene-butylene-styrene block copolymer uses high molecular weight SEBS.

[0059] Polypropylene uses low melt index homopolymer polypropylene PP.

[0060] The mineral oil used is cycloalkane mineral oil.

[0061] The inorganic filler is 1000 mesh calcium carbonate powder.

[0062] The antioxidant is prepared by compounding antioxidant 168 and antioxidant 1010 in a mass ratio of 0.65:0.35.

[0063] The lubricant is erucamide.

[0064] The dispersant is stearate.

[0065] In this embodiment, it should be noted that the styrene-ethylene-butylene-styrene block copolymer uses American Kraton G1651; the polypropylene uses Qilu Petrochemical T30S; the polyolefin elastomer POE uses ExxonMobil 6102; the mineral oil uses PetroChina Karamay Refining and Chemical Cycloalkane White Oil 4010; the inorganic filler uses 1000 mesh calcium carbonate from Henan Fuhai Mineral Products Co., Ltd.; the antioxidant uses German BASF antioxidant 168 and antioxidant 1010 in a composite mass ratio of 0.65:0.35; the lubricant uses Jiangxi Zhilian New Materials Co., Ltd.; and the dispersant uses zinc stearate BP7 from Jinan Century Tongda Chemical Co., Ltd.

[0066] In addition, this embodiment also provides a method for preparing the above-mentioned easy-to-puncture high-sealing medicinal thermoplastic elastomer particles, comprising the following steps:

[0067] Step 1: accurately weigh styrene-ethylene-butylene-styrene block copolymer, polyolefin elastomer POE, polypropylene, mineral oil, inorganic filler, antioxidant, lubricant and dispersant for use;

[0068] Step 2: Pour the styrene-ethylene-butylene-styrene block copolymer into a low-speed mixer and heat it to 45° C.

[0069] Step 3, atomize and spray the mineral oil into the styrene-ethylene-butylene-styrene block copolymer in a low-speed mixer at a speed of 5 L / min, stir at a low speed for 30 min, and then stand for 4 h to obtain a uniformly mixed mixture;

[0070] Step 4: Add polyolefin elastomer POE, polypropylene, inorganic filler, antioxidant, lubricant and dispersant to the obtained mixture, and mix in a high-speed mixer for 15 minutes to obtain a uniformly mixed formula;

[0071] Step 5: Extrude the obtained formula material on a twin-screw extruder, and water-cool the pellets to obtain finished thermoplastic elastomer pellets.

[0072] Among them, the temperatures of the twin-screw extruder are 165°C in temperature control zone 1, 205°C in temperature control zone 2, 215°C in temperature control zone 3, 225°C in temperature control zone 4, 220°C in temperature control zone 5, 215°C in temperature control zone 6, 185°C in temperature control zone 7, 185°C in temperature control zone 8, 165°C in temperature control zone 9, 165°C in temperature control zone 10, 215°C in screen changing temperature control zone, and 195°C in die head temperature control zone; the cooling water temperature of the water-cooled granulation is 45°C.

[0073] Example 3

[0074] The preparation method of the easily puncturable and highly airtight medicinal thermoplastic elastomer particles provided in this embodiment is basically the same as that in Example 1, except that: the specific raw material composition and the specific preparation method of the easily puncturable and highly airtight medicinal thermoplastic elastomer particles in this embodiment are different; the specific raw material composition and the specific preparation method of the easily puncturable and highly airtight medicinal thermoplastic elastomer particles in this embodiment are as follows:

[0075] The present embodiment provides an easy-to-puncture high-sealing medicinal thermoplastic elastomer granule, which is composed of the following raw materials in parts by weight: 20 parts of styrene-ethylene-butylene-styrene block copolymer, 10 parts of polyolefin elastomer POE, 4 parts of polypropylene, 45 parts of mineral oil, 1.5 parts of inorganic filler, 0.05 parts of antioxidant, 0.05 parts of lubricant and 0.05 parts of dispersant.

[0076] Among them, the styrene-ethylene-butylene-styrene block copolymer uses high molecular weight SEBS.

[0077] Polypropylene uses low melt index homopolymer polypropylene PP.

[0078] The mineral oil used is cycloalkane mineral oil.

[0079] The inorganic filler is 500-mesh calcium carbonate powder.

[0080] The antioxidant is prepared by compounding antioxidant 168 and antioxidant 1010 in a mass ratio of 0.65:0.35.

[0081] The lubricant is erucamide.

[0082] The dispersant is stearate.

[0083] In this embodiment, it should be noted that the styrene-ethylene-butylene-styrene block copolymer uses American Kraton G1651; the polypropylene uses Qilu Petrochemical T30S; the polyolefin elastomer POE uses ExxonMobil 6102; the mineral oil uses PetroChina Karamay Refining and Chemical Cycloalkane White Oil 4010; the inorganic filler uses 500 mesh calcium carbonate from Henan Fuhai Mineral Products Co., Ltd.; the antioxidant uses German BASF antioxidant 168 and antioxidant 1010 in a compound mass ratio of 0.65:0.35; the lubricant uses Jiangxi Zhilian New Materials Co., Ltd.; and the dispersant uses zinc stearate BP7 from Jinan Century Tongda Chemical Co., Ltd.

[0084] In addition, this embodiment also provides a method for preparing the above-mentioned easy-to-puncture high-sealing medicinal thermoplastic elastomer particles, comprising the following steps:

[0085] Step 1: accurately weigh styrene-ethylene-butylene-styrene block copolymer, polyolefin elastomer POE, polypropylene, mineral oil, inorganic filler, antioxidant, lubricant and dispersant for use;

[0086] Step 2: Pour the styrene-ethylene-butylene-styrene block copolymer into a low-speed mixer and heat it to 45° C.

[0087] Step 3, atomize and spray the mineral oil into the styrene-ethylene-butylene-styrene block copolymer in a low-speed mixer at a speed of 5 L / min, stir at a low speed for 30 min, and then stand for 4 h to obtain a uniformly mixed mixture;

[0088] Step 4: Add polyolefin elastomer POE, polypropylene, inorganic filler, antioxidant, lubricant and dispersant to the obtained mixture, and mix in a high-speed mixer for 15 minutes to obtain a uniformly mixed formula;

[0089] Step 5: Extrude the obtained formula material on a twin-screw extruder, and water-cool the pellets to obtain finished thermoplastic elastomer pellets.

[0090] Among them, the temperatures of the twin-screw extruder are 135°C in temperature control zone 1, 175°C in temperature control zone 2, 185°C in temperature control zone 3, 195°C in temperature control zone 4, 190°C in temperature control zone 5, 185°C in temperature control zone 6, 145°C in temperature control zone 7, 145°C in temperature control zone 8, 135°C in temperature control zone 9, 135°C in temperature control zone 10, 185°C in screen changing temperature control zone, and 165°C in die head temperature control zone; the cooling water temperature of the water-cooled granulation is 35°C.

[0091] Example 4

[0092] The preparation method of the easily puncturable and highly airtight medicinal thermoplastic elastomer particles provided in this embodiment is basically the same as that in Example 1, except that: the specific raw material composition and the specific preparation method of the easily puncturable and highly airtight medicinal thermoplastic elastomer particles in this embodiment are different; the specific raw material composition and the specific preparation method of the easily puncturable and highly airtight medicinal thermoplastic elastomer particles in this embodiment are as follows:

[0093] The present embodiment provides an easy-to-puncture high-sealing medicinal thermoplastic elastomer granule, which is composed of the following raw materials in parts by weight: 28 parts of styrene-ethylene-butylene-styrene block copolymer, 12.5 parts of polyolefin elastomer POE, 5 parts of polypropylene, 52 parts of mineral oil, 2.2 parts of inorganic filler, 0.1 parts of antioxidant, 0.1 parts of lubricant and 0.1 parts of dispersant.

[0094] Among them, the styrene-ethylene-butylene-styrene block copolymer uses high molecular weight SEBS.

[0095] Polypropylene uses low melt index homopolymer polypropylene PP.

[0096] The mineral oil used is cycloalkane mineral oil.

[0097] The inorganic filler is 800-mesh calcium carbonate powder.

[0098] The antioxidant is prepared by compounding antioxidant 168 and antioxidant 1010 in a mass ratio of 0.65:0.35.

[0099] The lubricant is erucamide.

[0100] The dispersant is stearate.

[0101] In this embodiment, it should be noted that the styrene-ethylene-butylene-styrene block copolymer uses TSRC 1651; the polypropylene uses Dushanzi 800E, and the polyolefin elastomer POE uses Dow 8999; the mineral oil uses PetroChina Karamay Refining and Chemical Cycloalkane White Oil 4006; the inorganic filler uses 800 mesh calcium carbonate from Henan Fuhai Mineral Products Co., Ltd.; the antioxidant uses German BASF antioxidant 168 and antioxidant 1010 in a compound mass ratio of 0.65:0.35; the lubricant uses Jiangxi Zhilian New Materials Co., Ltd.; and the dispersant uses zinc stearate BP7 from Jinan Century Tongda Chemical Co., Ltd.

[0102] In addition, this embodiment also provides a method for preparing the above-mentioned easy-to-puncture high-sealing medicinal thermoplastic elastomer particles, comprising the following steps:

[0103] Step 1: accurately weigh styrene-ethylene-butylene-styrene block copolymer, polyolefin elastomer POE, polypropylene, mineral oil, inorganic filler, antioxidant, lubricant and dispersant for use;

[0104] Step 2: Pour the styrene-ethylene-butylene-styrene block copolymer into a low-speed mixer and heat it to 45° C.

[0105] Step 3, atomize and spray the mineral oil into the styrene-ethylene-butylene-styrene block copolymer in a low-speed mixer at a speed of 5 L / min, stir at a low speed for 30 min, and then stand for 4 h to obtain a uniformly mixed mixture;

[0106] Step 4: Add polyolefin elastomer POE, polypropylene, inorganic filler, antioxidant, lubricant and dispersant to the obtained mixture, and mix in a high-speed mixer for 15 minutes to obtain a uniformly mixed formula;

[0107] Step 5: Extrude the obtained formula material on a twin-screw extruder, and water-cool the pellets to obtain finished thermoplastic elastomer pellets.

[0108] Among them, the temperatures of the twin-screw extruder are 150°C in temperature control zone 1, 190°C in temperature control zone 2, 200°C in temperature control zone 3, 210°C in temperature control zone 4, 205°C in temperature control zone 5, 200°C in temperature control zone 6, 165°C in temperature control zone 7, 165°C in temperature control zone 8, 150°C in temperature control zone 9, 150°C in temperature control zone 10, 200°C in screen changing temperature control zone, and 180°C in die head temperature control zone; the cooling water temperature of the water-cooled granulation is 40°C.

[0109] Comparative Example 1: The difference from Example 1 is that an equal amount of paraffin oil is used instead of mineral oil in this example.

[0110] Comparative Example 2: The difference from Example 1 is that in this example, the amount of mineral oil used is 44 parts, and the amount of styrene-ethylene-butylene-styrene block copolymer used is 36 parts.

[0111] Comparative Example 3: The difference from Example 1 is that in this example, the amount of mineral oil used is 61 parts, and the amount of styrene-ethylene-butylene-styrene block copolymer used is 19 parts.

[0112] Performance test: The thermoplastic elastomer particle samples provided in Examples 1 to 3 and Comparative Examples 1 to 3 are marked as Examples 1 to 4 and Comparative Examples 1 to 3, respectively; and the thermoplastic elastomer particles provided in Examples 1 to 4 and Comparative Examples 1 to 3 are tested for relevant properties according to the testing standard YBB00242004-2015.

[0113] The obtained test data are recorded in Table 1 below:

[0114] Table 1 Performance test results of each group of thermoplastic elastomer particles

[0115]

[0116]

[0117] By comparing and analyzing the relevant data in Table 1, it can be seen that the thermoplastic elastomer particles prepared in Comparative Example 1, which uses paraffin oil instead of mineral oil, have unqualified cytotoxicity, decreased puncture force, decreased retention force, and unqualified airtightness; the thermoplastic elastomer particles prepared in Comparative Example 2 have the problem of unqualified puncture force exceeding the standard; the thermoplastic elastomer particles prepared in Comparative Example 3 have the problem of unqualified airtightness; the thermoplastic elastomer particles prepared by the present invention optimize the raw material composition and raw material content by comparing the relevant properties of isoprene rubber (butyl rubber), and the prepared thermoplastic elastomer particles not only maintain the original punctureability of isoprene rubber (butyl rubber), but also retain the original high elasticity, while improving the tear resistance, aging resistance, easy puncture, high airtightness, the same material can be recycled, green environmental protection and carbon reduction, and no odor and no color change, which meets the safety requirements of food and medicine. This shows that the easy-to-puncture high-sealing medicinal thermoplastic elastomer particles and their preparation method provided by the present invention have a broader market prospect and are more suitable for promotion.

[0118] In the description of this specification, the description with reference to the terms "one embodiment", "example", "specific example", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0119] The preferred embodiments of the present invention disclosed above are only used to help illustrate the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to the specific implementation methods described. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present invention, so that those skilled in the art can understand and use the present invention well. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. A medicinal thermoplastic elastomer granule with easy puncture and high airtightness, characterized in that: The invention is composed of the following raw materials in parts by weight: 20 to 35 parts of styrene-ethylene-butylene-styrene block copolymer, 10 to 15 parts of polyolefin elastomer POE, 4 to 6 parts of polypropylene, 45 to 60 parts of mineral oil, 1.5 to 3 parts of inorganic filler, 0.05 to 0.15 parts of antioxidant, 0.05 to 0.15 parts of lubricant and 0.05 to 0.15 parts of dispersant.

2. The easy-to-puncture and highly airtight medicinal thermoplastic elastomer particles according to claim 1, characterized in that: The styrene-ethylene-butylene-styrene block copolymer is selected from high molecular weight SEBS.

3. The easy-to-puncture and highly airtight medicinal thermoplastic elastomer particles according to claim 1, characterized in that: The polypropylene is selected from low melt index homopolymer polypropylene PP.

4. The easy-to-puncture and highly airtight medicinal thermoplastic elastomer particles according to claim 1, characterized in that: The mineral oil is naphthenic mineral oil.

5. The easy-to-puncture and highly airtight medicinal thermoplastic elastomer particles according to claim 1, characterized in that: The inorganic filler is calcium carbonate powder with a mesh size of 500 to 1000.

6. The easy-to-puncture and highly airtight medicinal thermoplastic elastomer particles according to claim 1, characterized in that: The antioxidant is prepared by compounding antioxidant 168 and antioxidant 1010 in a mass ratio of 0.65:0.

35.

7. The easy-to-puncture and highly airtight medicinal thermoplastic elastomer particles according to claim 1, characterized in that: The lubricant is selected from any one of erucamide, oleamide and silicone masterbatch.

8. The easy-to-puncture and highly airtight medicinal thermoplastic elastomer particles according to claim 1, characterized in that: The dispersant is stearate.

9. The method for preparing the easily puncturable and highly airtight medicinal thermoplastic elastomer particles according to any one of claims 1 to 8, characterized in that: The following steps are involved: Step 1: accurately weigh styrene-ethylene-butylene-styrene block copolymer, polyolefin elastomer POE, polypropylene, mineral oil, inorganic filler, antioxidant, lubricant and dispersant for use; Step 2: Pour the styrene-ethylene-butylene-styrene block copolymer into a low-speed mixer and heat it to 45° C. Step 3, atomize and spray the mineral oil into the styrene-ethylene-butylene-styrene block copolymer in a low-speed mixer at a speed of 5 L / min, stir at a low speed for 30 min, and then stand for 4 h to obtain a uniformly mixed mixture; Step 4: Add polyolefin elastomer POE, polypropylene, inorganic filler, antioxidant, lubricant and dispersant to the obtained mixture, and mix in a high-speed mixer for 15 minutes to obtain a uniformly mixed formula; Step 5: Extrude the obtained formula material on a twin-screw extruder, and water-cool the pellets to obtain finished thermoplastic elastomer pellets.

10. The method for preparing the easy-to-puncture and highly airtight medicinal thermoplastic elastomer particles according to claim 9, characterized in that: In the step five, the temperatures of the twin-screw extruder are 135-165°C in temperature control zone one, 175-205°C in temperature control zone two, 185-215°C in temperature control zone three, 195-225°C in temperature control zone four, 190-220°C in temperature control zone five, 185-215°C in temperature control zone six, 145-185°C in temperature control zone seven, 145-185°C in temperature control zone eight, 135-165°C in temperature control zone nine, 135-165°C in temperature control zone ten, 185-215°C in screen changing temperature control zone, and 165-195°C in die head temperature control zone; the cooling water temperature of the water-cooled granulation is 35-45°C.

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