Locking device, locking system and implant

Abstract

The invention provides a locking device, a locking system and an implant. The locking device comprises a shell and a winding assembly at least partially contained in the shell. The winding assembly can rotate relative to the shell. The winding assembly comprises a winding piece, a connecting piece and a locking piece. The locking piece is elastic. The locking piece is arranged between the winding piece and the connecting piece. And the winding piece is fixedly connected with the connecting piece. Wherein the locking piece is matched with the shell to limit rotation of the winding assembly, and the locking piece is configured to be capable of being separated from limitation of the shell under the action of external force. According to the locking device, the locking system and the implant, when the elastic locking piece is matched with the shell to limit rotation of the winding assembly, the locking device is in the locking state; when the locking piece is stressed to deform and is separated from limitation of the shell, the locking device is in an unlocking state, and at the moment, the winding assembly can be driven to rotate clockwise or anticlockwise.

Description

Technical Field

[0001] The present application relates to the field of medical devices, and in particular to a locking device, a locking system and an implant. Background Art

[0002] Valve ring dilatation is one of the most common causes of mitral and tricuspid valve diseases, which usually leads to mitral and tricuspid valve insufficiency and blood reflux. Annuloplasty is performed on the dilated valve ring to reduce the area of ​​the mitral or tricuspid valve orifice by contracting the valve ring, so that the valve leaflets can fit together during ventricular contraction, thereby reducing or eliminating reflux.

[0003] For some annuloplasty applications, an annuloplasty structure is implanted on the valve ring, and the length of the flexible elongated member (e.g., tension wire, adjustment wire) of the annuloplasty structure is adjusted to reduce the circumference of the valve ring to treat regurgitation. After the length of the flexible elongated member is adjusted, it needs to be locked by a locking device to maintain the effect of reducing the valve ring. Summary of the invention

[0004] An embodiment of the present application provides a locking device. The locking device includes a housing and a winding assembly at least partially accommodated in the housing. The winding assembly can rotate relative to the housing. The winding assembly includes a winding member, a connecting member and a locking member. The locking member is elastic. The locking member is arranged between the winding member and the connecting member. The winding member is fixedly connected to the connecting member. The locking member cooperates with the housing to limit the rotation of the winding assembly, and the locking member is configured to be able to break away from the restriction of the housing under the action of an external force.

[0005] The embodiment of the present application also provides a locking system. The locking system includes a conveying device and the above-mentioned locking device. The conveying device includes an outer tube, an inner tube movably installed in the outer tube, and a slender rod movably installed in the inner tube. The distal end of the outer tube is connected to the shell and is relatively fixed. The distal end of the inner tube is connected to the connecting piece and is relatively fixed. Among them, the outer tube is configured to limit the rotation of the shell, the slender rod is configured to provide an external force to the locking piece to make the locking piece break away from the restriction of the shell, and the inner tube is configured to drive the winding assembly to rotate relative to the shell.

[0006] The present application also provides an implant. The implant comprises a flexible elongated member, a plurality of anchoring members and the locking device. The flexible elongated member connects the plurality of anchoring members and the locking device. Each of the anchoring members is configured to be anchored to a tissue. The flexible elongated member is configured to adjust the spacing between the plurality of anchoring members. The locking device is configured to adjust the length of the flexible elongated member and to lock the length of the flexible elongated member.

[0007] In the locking device, locking system and implant of the embodiments of the present application, when the elastic locking member cooperates with the shell to limit the rotation of the winding assembly, the locking device is in a locked state; when the locking member is deformed by force and breaks away from the restriction of the shell, the locking device is in an unlocked state, at which time the winding assembly can be driven to rotate clockwise or counterclockwise. Therefore, after the flexible slender member is connected to the locking device, force is applied to make the locking member break away from the restriction of the shell, and the flexible slender member can be wound around the winding member by driving the winding assembly to rotate relative to the shell. When the flexible slender member is adjusted to a suitable length, the locking member is restored to cooperate with the shell to limit the rotation of the winding assembly relative to the shell, and the flexible slender member is locked by the locking device. BRIEF DESCRIPTION OF THE DRAWINGS

[0008] In order to more clearly illustrate the technical solutions in the implementation methods of the present application or the background technology, the drawings required for the implementation methods of the present application are described below. Obviously, the drawings described below are some implementation methods of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0009] Figure 1 It is a schematic diagram of the three-dimensional structure of a locking device according to an embodiment of the present application;

[0010] Figure 2 is a schematic structural diagram of an implant (flexible elongated member is tightened) according to an embodiment of the present application;

[0011] Figure 3 is a schematic diagram of the three-dimensional structure of an anchor member according to an embodiment of the present application;

[0012] Figure 4 is a schematic diagram of the three-dimensional structure of an anchor member according to another embodiment of the present application;

[0013] Figure 5 yes Figure 3 A schematic diagram of the connection between the anchor member and the flexible elongated member shown;

[0014] Figure 6 is a schematic structural diagram of an implant (the flexible elongated member is tightened) according to another embodiment of the present application;

[0015] Figure 7 This is a schematic diagram of the connection between the flexible elongated member and the conveying member according to one embodiment of the present application;

[0016] Figure 8 yes Figure 1 A cross-sectional view of the locking device shown in a locked state;

[0017] Fig. 9 yes Figure 1 A cross-sectional view showing the locking device in an unlocked state;

[0018] Fig.10 yes Figure 1 Another cross-sectional view showing the locking device in an unlocked state;

[0019] Fig.11 yes Figure 1 A cross-sectional view of the locking device shown;

[0020] Fig.12 yes Figure 1 A schematic diagram of the locking device after the winding member is wound around the flexible elongated member;

[0021] Fig.13 yes Figure 1 An exploded schematic diagram of the locking device shown;

[0022] Fig.14 yes Figure 8 A schematic diagram of the three-dimensional structure of the winding assembly shown;

[0023] Fig.15 yes Fig.14 An exploded schematic diagram of the winding assembly shown;

[0024] Fig.16 yes Fig.15 A schematic diagram of the three-dimensional structure of the winding member shown;

[0025] Fig.17 yes Fig.16 A partial structural schematic diagram of the winding member shown;

[0026] Fig.18 yes Fig.13 A schematic diagram of the three-dimensional structure of the upper shell shown;

[0027] Fig.19 yes Figure 8 A cross-sectional view showing the locking end of the locking portion engaging with the locking groove of the housing;

[0028] Fig. 20 is a front view of a locking device according to another embodiment of the present application;

[0029] Fig.21 yes Fig. 20 A cross-sectional view of the locking device shown in a locked state;

[0030] Fig. 22 yes Fig. 20 A cross-sectional view showing the locking device in an unlocked state;

[0031] Fig.23 yes Fig.21 An exploded schematic diagram of the winding assembly shown;

[0032] Fig.24 yes Fig.21 Another exploded schematic diagram of the winding assembly shown;

[0033] Fig.25 yes Fig.21 Another exploded schematic diagram of the winding assembly shown;

[0034] Fig.26 yes Fig.23 A schematic diagram of the three-dimensional structure of the winding member shown;

[0035] Fig. 27 yes Fig.21 A cross-sectional view showing the locking end of the locking portion engaging with the locking groove of the housing;

[0036] Fig.28 is a cross-sectional view of a locking device in another embodiment of the present application in a locked state;

[0037] Fig.29 yes Fig.28 A cross-sectional view showing the locking device in an unlocked state;

[0038] Fig.30 yes Fig.28 An exploded schematic diagram of the winding assembly shown;

[0039] Fig.31 yes Fig.28 Another exploded schematic diagram of the winding assembly shown;

[0040] Fig.32 yes Fig.28 Another exploded schematic diagram of the winding assembly shown;

[0041] Fig.33 yes Fig.30 A schematic diagram of the three-dimensional structure of the winding member shown;

[0042] Fig.34 yes Fig.28 A cross-sectional view showing the locking end of the locking portion engaging with the locking groove of the housing;

[0043] Fig.35 is a front view of a locking system according to an embodiment of the present application;

[0044] Fig.36 yes Fig.35 A schematic diagram of the separation of the conveying device and the locking device shown;

[0045] Fig.37 yes Fig.35 A cross-sectional view of the locking system shown;

[0046] Fig.38 yes Fig.35An exploded schematic diagram of the conveying device shown;

[0047] Figure 39 to Figure 41 A schematic diagram of a process of applying a locking device to mitral annuloplasty according to an embodiment of the present application. DETAILED DESCRIPTION

[0048] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0049] The limiting terms "proximal" and "distal" described in this application are commonly used terms in the field of interventional medicine. Specifically, the "distal" refers to the end away from the operator during the surgical operation, and the "proximal" refers to the end close to the operator during the surgical operation. Axial refers to the direction parallel to the line connecting the distal and proximal centers of the instrument or component, radial refers to the direction perpendicular to the axial direction, and circumferential refers to the direction around the axial direction. Unless otherwise defined, all technical and scientific terms used in this application have the same meaning as commonly understood by technicians in the technical field to which this application belongs. The commonly used terms used in the specification of this application are only for the purpose of describing specific embodiments and are not to be construed as limitations on this application.

[0050] In the description of the present application, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected" and "connected" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a direct connection or an indirect connection through an intermediate medium, and it can be the internal connection of two elements or the interaction relationship between two elements.

[0051] The directional terms mentioned in the embodiments of the present application, such as "upper", "lower", "left", "right", "inner", "outer", etc., are only referenced to the directions of the drawings. Therefore, the directional terms used are for better and clearer description and understanding of the embodiments of the present application, rather than indicating or implying that the devices or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the embodiments of the present application. "Multiple" means at least two.

[0052] In the embodiments of the present application, the terms "first", "second", and "third" are used for descriptive purposes only and are not to be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Thus, a feature defined as "first", "second", and "third" may explicitly or implicitly include one or more of the features.

[0053] In the implementation manner of the present application, the character " / " generally indicates that the objects before and after are in an "or" relationship. For ordinary technicians in this field, the specific meanings of the above terms in the present application can be understood according to specific circumstances.

[0054] The disclosure of this article provides many different implementations or examples for implementing different structures of the present application. It is to be understood that the specific implementations described herein are only used to explain the relevant application, rather than to limit the application. It should also be noted that, for ease of description, only the parts related to the application are shown in the accompanying drawings. The present application will be described in detail below with reference to the accompanying drawings and in combination with the implementations.

[0055] See also Figure 1 and Figure 2 , an embodiment of the present application provides a locking device 10. The locking device 10 can be disposed in an implant 100 used for annuloplasty. The implant 100 includes a flexible elongated member 30, a plurality of anchors 50 and a locking device 10. The flexible elongated member 30 connects the plurality of anchors 50 and the locking device 10. Each anchor 50 is configured to be anchored to tissue. The flexible elongated member 30 is configured to adjust the spacing between the plurality of anchors 50. The locking device 10 is configured to adjust the length of the flexible elongated member 30 and to lock the length of the flexible elongated member 30. The locking device 10 can also be applied to chordal repair, in which a flexible elongated member is used as an artificial chord connecting the valve leaflet to the papillary muscle / ventricular wall, and the locking device 10 adjusts the length of the flexible elongated member and locks the length of the flexible elongated member to thereby adjust and fix the length of the artificial chord.

[0056] In the present application, the flexible elongated member 30 may be a flexible linear object, such as a thread, a filament, a rope, a strip, a belt, etc. The radial cross-sectional shape of the flexible elongated member 30 may be circular, oblate, rectangular, square or other shapes, etc., which is not limited in the present application. The flexible elongated member 30 may be made of a biocompatible metal material and / or polymer material, such as stainless steel 316L, tungsten, tantalum, nickel titanium, polyethylene, polyamide, polypropylene, polyurethane, etc. Exemplarily, the flexible elongated member 30 is a slender wire, which may be woven from a plurality of metal filaments. The flexible elongated member 30 has a developing property under a DSA (Digital subtraction angiography) device.

[0057] The following is a specific description using the locking device 10 applied to annuloplasty as an example.

[0058] During annuloplasty, after multiple anchors 50 connected by the flexible elongated member 30 are implanted into the heart tissue, the locking device 10 adjusts the spacing between the multiple anchors 50 by tightening or loosening the flexible elongated member 30 (i.e., adjusting the length of the flexible elongated member 30), thereby adjusting the size of the physiological valve ring. The locking device 10 can lock the length of the flexible elongated member 30 to maintain the adjusted size of the valve ring. The locking device 10 can tighten the flexible elongated member 30 to reduce the spacing between the multiple anchors 50, thereby reducing the size of the patient's valve ring to achieve the purpose of reducing blood reflux. After the valve ring is reduced to achieve the desired effect, the locking device 10 can lock the length of the flexible elongated member 30 to maintain the tension of the flexible elongated member 30, thereby maintaining the effect of reducing the valve ring. In the case where the flexible elongated member 30 is over-tightened (i.e., the spacing between the multiple anchors 50 is too small), the locking device 10 can loosen the flexible elongated member 30 to readjust the spacing between the multiple anchors 50 until the size adjustment of the valve ring reaches the desired effect.

[0059] It can be understood that the multiple anchoring members 50 connected by the flexible slender member 30 can be anchored to cardiac tissues such as the mitral valve annulus, the tricuspid valve annulus, the left ventricular wall or the right ventricular wall. When the implant 100 is implanted in the valve annulus, the valve annulus is directly reduced by tightening the flexible slender member 30. When the implant 100 is implanted in the ventricular wall below the valve annulus, such as the ventricular wall 0.5-2 cm below the valve annulus, the purpose of reducing the valve annulus can be achieved by tightening the flexible slender member 30 to narrow the ventricle and reduce the volume of the ventricle. It should be noted that reducing the volume of the left ventricle can also treat ischemic heart failure. The implant 100 is specifically described below using the valve annulus as an example.

[0060] See also Figures 3 to 5 In some embodiments, the anchor 50 includes a tissue engaging element 52, a head 54, and a connecting structure 56. The head 54 is connected to the proximal end of the tissue engaging element 52. The connecting structure 56 can be rotatably sleeved on the head 54 or the proximal end of the tissue engaging element 52. The connecting structure 56 is provided with a connecting hole 560. The connecting hole 560 is configured to allow the flexible elongated member 30 to pass through. It can be understood that the anchor 50 is connected to the flexible elongated member 30 through the connecting hole 560 of the connecting structure 56. The distal end of the flexible elongated member 30 can be connected to the connecting structure 56 of the first anchor 50 anchored to the tissue, and the two cannot be separated and always remain connected. The flexible elongated member 30 can movably pass through the connecting holes 560 of the remaining anchors 50 anchored to the tissue, that is, the connecting structures 56 of the remaining anchors 50 can slide along the flexible elongated member 30.

[0061] In some examples, the connection structure 56 includes a connection element 562 and a connection ring 564. The connection element 562 is rotatably mounted on the head 54 of the anchor 50 or the proximal portion of the tissue engaging element 52. The connection ring 564 is movably connected to the connection element 562, and the connection ring 564 defines a connection hole 560. In other examples, the connection structure 56 includes a connection element 562, and the connection element 562 includes an annular member 5622 and a protrusion 5624 fixed to the annular member 5622. The annular member 5622 is rotatably mounted on the head 54 of the anchor 50 or the proximal portion of the tissue engaging element 52. The connection hole 560 is opened in the protrusion 5624. In other examples, the connection structure 56 may also only include a connection ring 564 that is rotatably mounted on the head 54 of the anchor 50 or the proximal portion of the tissue engaging element 52, and the connection ring 564 defines the connection hole 560.

[0062] See also Figure 5 In some embodiments, a fixing member 31 is provided at the distal end of the flexible elongated member 30. The fixing member 31 is located at the distal end side of the connecting hole 560 of the first anchoring member 50. The fixing member 31 is connected to the connecting structure 56 to limit the proximal movement of the first anchoring member 50 relative to the flexible elongated member 30. In this way, the distal end of the flexible elongated member 30 is connected to the connecting structure 56 of the first anchoring member 50 and cannot be separated. It can be understood that the flexible elongated member 30 passes through the connecting hole 560 of the first anchoring member 50 so that the fixing member 31 at the distal end is located at the distal end side of the connecting hole 560, which can avoid the fixing member 31 being arranged at the proximal side of the connecting hole 560 to increase the distance between the first anchoring member 50 and the second anchoring member 50 and cause uneven contraction of the valve ring, thereby avoiding structural changes in the leaflets in this area. The connection of the fixing member 31 to the connecting structure 56 of the first anchoring member 50 can limit the proximal movement of the first anchoring member 50 relative to the flexible elongated member 30, thereby avoiding affecting the surgical operation.

[0063] Exemplarily, the connection structure 56 includes a connection element 562 and a connection ring 564. The connection element 562 can be rotatably sleeved on the head 54 of the anchor 50. The fixing member 31 is a hollow cylindrical structure. The outer diameter of the fixing member 31 is larger than the inner diameter of the connection ring 564 (i.e., the aperture of the connection hole 560). The two free ends of the flexible slender member 30 pass through the connection ring 564 of the first anchor 50 from the proximal end to the distal end, and then pass through the fixing member 31, and the two free ends of the flexible slender member 30 (i.e., the distal end of the flexible slender member 30) are fixedly connected to the fixing member 31 by crimping. The fixing member 31 can be covered with a protective film 310, and the protective film 310 is connected to the connection ring 564 by sutures, so that the fixing member 31 is connected to the connection structure 56 of the first anchor 50. The protective film 310 can be a biocompatible film, and the material can be selected from PET (Polyethylene terephthalate). In other examples, the fixing member 31 can be connected to the connection structure 56 of the first anchoring member 50 by welding or bonding. The flexible elongated member 30 can have only one free end fixedly connected to the fixing member 31. In addition, after the distal end of the flexible elongated member 30 is connected to the connection structure 56 of the first anchoring member 50, the flexible elongated member 30 and the connection structure 56 of the first anchoring member 50 can be connected by knotting, winding, welding, or bonding so that the flexible elongated member 30 and the connection structure 56 of the first anchoring member 50 cannot be separated and always remain connected.

[0064] The tissue engaging element 52 is configured to be anchored into the tissue. The tissue engaging element 52 has a distal tip 522, which is easy to pierce the tissue. The head 54 is configured to be connected to the driving device. In some examples, the tissue engaging element 52 may be a spiral nail, and the spiral nail is fixedly connected to the head 54. The anchor 50 is driven to rotate by the rotation of the driving device so that the spiral nail is anchored into the tissue. The spiral nail can be made of stainless steel, titanium alloy or cobalt alloy. In other examples, the tissue engaging element 52 can be a plurality of pre-shaped nails, and the plurality of pre-shaped nails are fixedly connected to the head 54. The pre-shaped nail is made of shape memory material (such as nickel-titanium-based shape memory alloy, copper-based shape memory alloy, iron-based shape memory alloy, etc.) and is made by bending and heat setting. The anchor 50 is anchored into the tissue by the driving device. The pre-shaped nail is deformed by the restraint of the delivery sheath, and the overall radial size becomes smaller for easy delivery. When the anchor 50 is separated from the delivery sheath, the pre-shaped nail returns to the predetermined curved shape. The pre-shaped nail is in a curved shape when engaged with tissue to prevent the anchor 50 from falling off.

[0065] See also Figure 6In some embodiments, the implant 100 further includes at least one spacer 70. The spacer 70 is movably connected to the flexible elongated member 30. The spacer 70 is disposed between two adjacent anchoring members 50. It can be understood that the spacer 70 can prevent the flexible elongated member 30 from being over-tightened, resulting in the distance between two adjacent anchoring members 50 being too short, thereby affecting the effect of reducing the valve ring. At the same time, the spacer 70 can play a buffering role, dispersing the tightening force on the anchoring member 50, and ensuring the stable implantation of the anchoring member 50. Among them, the spacer 70 is a tubular member with a certain length, and is made of a biocompatible material. The spacer 70 can be wrapped with a coating to reduce the risk of heart tissue being damaged by the spacer 70 and to increase biocompatibility.

[0066] Optionally, a spacer 70 may be provided between any two adjacent anchors 50 among the plurality of anchors 50, that is, the anchors 50 and the spacers 70 are staggered. Of course, a spacer 70 may also be provided every two or more anchors 50, that is, a spacer 70 may be provided between some two adjacent anchors 50, and no spacer 70 may be provided between some two adjacent anchors 50, which is not limited in the present application.

[0067] See also Figure 7 In some embodiments, the proximal end of the flexible elongated member 30 is connected to a conveying member 200. It is understood that the distal end of the flexible elongated member 30 is connected to the first anchoring member 50. The flexible elongated member 30 and the conveying member 200 are transported into the patient's body along with the first anchoring member 50, and the proximal end of the conveying member 200 extends outside the patient's body. The anchoring member 50, the spacer 70, the locking device 10, etc. are transported to the flexible elongated member 30 through the conveying member 200. After the locking device 10 is stably connected to the flexible elongated member 30, the conveying member 200 is disconnected from the flexible elongated member 30 and withdrawn from the patient's body. In this way, the flexible elongated member 30 can select a suitable implantation length, and there is no need to cut the flexible elongated member 30 in the body, which avoids the falling off of particles on the wire, and the operation is safer.

[0068] In the present application, the conveying member 200 may be a flexible linear object, such as a thread, a wire, a rope, a strip, a belt, etc. The radial cross-sectional shape of the conveying member 200 may be circular, oblate, rectangular, square, or other shapes, etc., which is not limited in the present application. The conveying member 200 may be made of a biocompatible metal material and / or a polymer material, such as stainless steel 316L, tungsten, tantalum, nickel titanium, polyethylene, polyamide, polypropylene, polyurethane, etc. Exemplarily, the conveying member 200 is a slender wire, such as a polymer wire.

[0069] exist Figure 7In the example of FIG. 1 , the proximal end of the flexible elongated member 30 is connected to the distal end of the conveying member 200 in a U-shaped manner. In this way, the conveying member 200 can be separated from the flexible elongated member 30 by pulling the conveying member 200 outside the body, which is easy to operate. In other embodiments, the conveying member 200 can also be detachably connected to the flexible elongated member 30 by means of threaded connection, snap connection, etc., which will not be described in detail.

[0070] exist Figure 5 In the example of FIG. 1 , the length of the flexible elongated member 30 is long enough. When the flexible elongated member 30 is delivered into the patient's body along with the first anchor 50, the proximal end of the flexible elongated member 30 can extend outside the patient's body, making it easier to wear the anchor 50, the spacer 70, the locking device 10, etc. After the locking device 10 is stably connected to the flexible elongated member 30, the excess portion of the flexible elongated member 30 can be cut off by a wire cutter.

[0071] See also Figures 8 to 10 , Figure 21 to Figure 22 and Figure 28 to Figure 29 In some embodiments, the locking device 10 includes a housing 12 and a winding assembly 14 at least partially accommodated in the housing 12. The winding assembly 14 can rotate relative to the housing 12. The winding assembly 14 includes a winding member 142, a connecting member 144, and a locking member 146. The locking member 146 is elastic. The locking member 146 is disposed between the winding member 142 and the connecting member 144, and the winding member 142 is fixedly connected to the connecting member 144. Among them, the locking member 146 cooperates with the housing 12 to limit the rotation of the winding assembly 14, and the locking member 146 is configured to be able to break away from the restriction of the housing 12 under the action of an external force.

[0072] It can be understood that when the elastic locking member 146 cooperates with the housing 12 to restrict the rotation of the winding assembly 14, the locking device 10 is in a locked state; when the locking member 146 is deformed by force and breaks away from the restriction of the housing 12, the locking device 10 is in an unlocked state, and the winding assembly 14 can be driven to rotate clockwise or counterclockwise. Fig.11 ), the locking member 146 is forced to break away from the restriction of the housing 12, and the flexible elongated member 30 can be wound around the winding member 142 by driving the winding assembly 14 to rotate relative to the housing 12 (see Fig.12 When the flexible elongated member 30 is adjusted to a suitable length, the locking member 146 is restored to cooperate with the housing 12 to restrict the winding assembly 14 from rotating relative to the housing 12 . At this time, the flexible elongated member 30 is locked by the locking device 10 .

[0073] The flexible elongated member 30 is wound around the winding member 142 at least twice, preferably at least three times. In this way, there is friction between the flexible elongated member 30 and the winding member 142, and there is also friction between the multiple turns of the flexible elongated member 30 wound around the winding member 142 due to overlap. The friction can offset the tension generated by the movement of the leaflets, ensuring that the flexible elongated member 30 is not pulled by the tension generated by the movement of the leaflets, and the locking device 10 is stably connected to the flexible elongated member 30. Generally, the flexible elongated member 30 is wound around the winding member 142 multiple times, and the friction between the flexible elongated member 30 wound multiple times is greater, the locking force of the locking device 10 on the flexible elongated member 30 is stronger, and the fatigue performance of the flexible elongated member 30 is better.

[0074] Please combine Fig. 9 , Fig.13 , Fig. 22 and Fig.29 In some embodiments, the housing 12 is provided with a proximal opening 121. The connecting member 144 is provided with a channel 1440 extending along its axial direction. The channel 1440 passes through the proximal surface and the distal surface of the connecting member 144. The channel 1440 is exposed to the proximal opening 121. The channel 1440 is configured for the elongated rod 26 to pass through. The locking member 146 is responsive to the force applied thereto by the elongated rod 26 so that the locking member 146 is disengaged from the restriction of the housing 12.

[0075] It can be understood that the winding member 142 and the locking member 146 are accommodated in the housing 12 as a whole, and the connecting member 144 is at least partially accommodated in the housing 12. The channel 1440 of the connecting member 144 is exposed to the proximal opening 121 of the housing 12. The connecting member 144 may be located in the housing 12 as a whole, the channel 1440 corresponds to the position of the proximal opening 121, and the slender rod 26 first passes through the proximal opening 121 and then passes through the channel 1440; or the connecting member 144 may be partially located in the housing 12, and partially extends from the proximal opening 121, and the slender rod 26 is directly passed through the channel 1440. The slender rod 26 passes through the channel 1440 of the connecting member 144 and contacts the locking member 146 disposed between the winding member 142 and the connecting member 144. The slender rod 26 applies force to the locking member 146 so that the locking member 146 is deformed and breaks away from the restriction of the housing 12. At this time, the winding assembly 14 can rotate bidirectionally relative to the housing 12. When the locking device 10 needs to be locked, the slender rod 26 is removed, and the locking member 146 re-matches with the housing 12 to restrict the rotation of the winding assembly 14 due to its own elastic recovery shape (ie, returns to the natural state).

[0076] See also Fig.18 , Fig.19 , Fig. 27 and Fig.34In some embodiments, the locking member 146 includes an elastic locking portion 1462. The locking portion 1462 is in an elongated shape and includes two opposite ends, at least one of which is a locking end 1462a. At least one locking groove 123 is provided in the housing 12 along its circumference. The locking end 1462a cooperates with one of the locking grooves 123 to limit the rotation of the winding assembly 14. The locking portion 1462 is configured to enable the locking end 1462a to be free from the restriction of the locking groove 123 under the action of an external force.

[0077] It can be understood that when the locking portion 1462 is in a natural state, that is, the locking portion 1462 is not affected by external force, the locking end 1462a of the locking portion 1462 is located in one of the locking grooves 123. Since the locking end 1462a is against the surface of the locking groove 123, the locking end 1462a is restricted by the locking groove 123, and the winding assembly 14 cannot rotate relative to the shell 12. When the locking portion 1462 is deformed by external force so that the locking end 1462a disengages from the locking groove 123, the winding assembly 14 can rotate relative to the shell 12. One locking groove 123, two locking grooves 123 or more locking grooves 123 can be arranged along the circumference of the shell 12. Preferably, the locking portion 1462 is evenly provided with a plurality of locking grooves 123 along the circumference. The greater the number of locking grooves 123, the higher the adjustment accuracy of the length of the flexible slender member 30. Fig.19 , Fig. 27 and Fig.34 In the example of , 10 locking grooves 123 are provided in the shell 12 along its circumference. In other examples, 8 locking grooves 123, 9 locking grooves 123, 11 locking grooves 123, 12 locking grooves 123, etc. may be provided in the shell 12 along its circumference. The number of the locking grooves 123 is not specifically limited in the present application.

[0078] The locking portion 1462 may be made of elastic material, such as shape memory alloy (nickel-titanium-based shape memory alloy Ni-TiSMA, copper-based shape memory alloy Cu SMA, iron-based shape memory alloy Fe SMA, etc.), stainless steel, etc. In one example, the locking portion 1462 is made of nickel-titanium alloy.

[0079] In some embodiments, the surface of the locking groove 123 includes a blocking surface 1232, a guide surface 1234, and a transition surface 1236 connecting the blocking surface 1232 and the guide surface 1234. The transition surface 1236 is arc-shaped. When the locking portion 1462 is in a natural state, the locking end 1462a is located in one of the locking grooves 123, and the stopper is substantially parallel to the blocking surface 1232. It can be understood that when the locking end 1462a of the stopper is located in the locking groove 123 and remains stationary, the stopper is substantially parallel to the blocking surface 1232 of the locking groove 123, which is conducive to preventing the winding assembly 14 from rotating relative to the housing 12. When the winding assembly 14 stops rotating, if the locking portion 1462 has not moved to a position substantially parallel to the blocking surface 1232, under the elastic action of the locking portion 1462 itself (after the external force applied to the locking portion 1462 is removed, the locking portion 1462 has a tendency to return to a natural state), the locking portion 1462 moves along the guide surface 1234 to a position substantially parallel to the blocking surface 1232. In other embodiments, when the locking end 1462a of the stopper is located in the locking groove 123 and remains stationary, the locking portion 1462 and the blocking surface 1232 may intersect and have an angle.

[0080] See also Fig.11 In some embodiments, the housing 12 is provided with a first through hole 125. The winding member 142 is provided with a second through hole 1420. The first through hole 125 and the second through hole 1420 are configured to allow the flexible elongated member 30 to pass through. The winding assembly 14 is configured to rotate relative to the housing 12 to wind the flexible elongated member 30 onto the winding member 142 or to release the flexible elongated member 30 from the winding member 142. It can be understood that the flexible elongated member 30 moves through the first through hole 125 of the housing 12 and the second through hole 1420 of the winding member 142, so that the flexible elongated member 30 is connected to the locking device 10. The winding assembly 14 can be rotated forward relative to the housing 12 to wind the flexible elongated member 30 onto the winding member 142. The winding assembly 14 can be rotated reversely relative to the housing 12 to release the flexible elongated member 30 from the winding member 142. In the present application, the rotation direction of the winding assembly 14 that causes the flexible elongated member 30 to be wound around the winding member 142 is defined as a forward rotation, and the rotation direction of the winding assembly 14 that causes the flexible elongated member 30 to be unwound from the winding member 142 is defined as a reverse rotation.

[0081] Exemplarily, the housing 12 is provided with first through holes 125 on two opposite sides, so that the flexible elongated member 30 can enter the housing 12 from the first through hole 125 on one side, pass through the second through hole 1420 of the winding member 142, and then pass out from the first through hole 125 on the other side. In one example, the two first through holes 125 are symmetrically arranged about the central axis of the housing 12, and the central axis of the two first through holes 125 and the central axis of the second through hole 1420 are in the same plane. In this way, the winding assembly 14 can be rotated so that the central axis of the second through hole 1420 is substantially colinear with the central axis of the two first through holes 125, which is conducive to the flexible elongated member 30 smoothly passing through the two first through holes 125 and the second through hole 1420. In other examples, the housing 12 can also be provided with only one first through hole 125.

[0082] See also Figure 1 and Fig.13 In some embodiments, the housing 12 includes an upper housing 122, a lower housing 124, and two annular members 126. The upper housing 122 is fixedly connected to the lower housing 124. The two annular members 126 are respectively fixedly arranged on opposite sides of the lower housing 124 to form two first through holes 125. Specifically, the upper housing 122 and the lower housing 124 can be fixedly connected by welding, bonding, threaded connection, etc. Mounting holes are provided on opposite sides of the lower housing 124, and the two annular members 126 are respectively fixedly installed in the mounting holes. The inner and outer sides of the annular member 126 are rounded to reduce damage to the flexible elongated member 30.

[0083] See also Figures 14 to 16 , Figure 23 to Figure 26 and Figure 30 to Figure 33 In some embodiments, the winding member 142 includes a bobbin 1422 and a fixing seat 1424 fixedly connected to the bobbin 1422. The connecting member 144 is fixedly connected to the fixing seat 1424. The fixing seat 1424 is provided with a receiving groove 1424a. The locking portion 1462 is received in the receiving groove 1424a. When the locking portion 1462 is in a natural state, the locking end 1462a extends out of the receiving groove 1424a and cooperates with one of the locking grooves 123 (see Figure 8 , Fig.21 and Fig.28 When the locking portion 1462 is subjected to an external force, the locking portion 1462 is deformed so that the locking end 1462a retracts toward the receiving groove 1424a, and the locking end 1462a is free from the restriction of the locking groove 123 (see Fig. 9 , Fig. 22 and Fig.29 ).

[0084] It can be understood that the second through hole 1420 of the winding member 142 is opened on the bobbin 1422, and the flexible elongated member 30 is wound around the bobbin 1422 of the winding member 142. The fixing seat 1424 is fixedly connected to the connecting member 144, and together define the activity space of the locking member 146. In the illustrated example, the bobbin 1422 is located at the distal end side of the fixing seat 1424. Since the locking portion 1462 is in the shape of an elongated strip, when the locking portion 1462 is not subjected to external force, the locking portion 1462 is substantially straight and its locking end 1462a extends out of the receiving groove 1424a and cooperates with one of the locking grooves 123 of the housing 12. When the middle part of the locking portion 1462 is subjected to external force, the locking portion 1462 is deformed and bent toward the distal end of the receiving groove 1424a, so that the locking end 1462a retracts along the radial direction of the receiving groove 1424a, and the locking end 1462a is free from the restriction of the locking groove 123.

[0085] See also Fig.10 , Fig.15 and Fig.23 In some embodiments, the connector 144 includes a first connector 1442. The fixing seat 1424 is fixedly received in the inner cavity of the first connector 1442. The first connector 1442 is provided with an avoidance groove 1442a corresponding to the receiving groove 1424a. It can be understood that the locking portion 1462 is received in the receiving groove 1424a of the fixing seat 1424, and the fixing seat 1424 is fixedly received in the inner cavity of the first connector 1442, so that the locking portion 1462 is restricted between the winding member 142 and the connector 144. The first connector 1442 is provided with an avoidance groove 1442a corresponding to the receiving groove 1424a to avoid affecting the locking end 1462a from extending out of the receiving groove 1424a.

[0086] Further, the housing 12 is provided with a proximal opening 121. The connecting member 144 also includes a second connecting portion 1444 fixedly connected to the first connecting portion 1442. The second connecting portion 1444 extends from the proximal opening 121. It can be understood that the first connecting portion 1442 is accommodated in the housing 12, and the second connecting portion 1444 extends from the proximal opening 121. The connecting member 144 is provided with a channel 1440 extending along its axial direction. The channel 1440 passes through the proximal surface of the second connecting portion 1444 and the distal surface of the first connecting portion 1442, that is, a portion of the channel 1440 coincides with the inner cavity of the first connecting portion 1442. The second connecting portion 1444 of the connecting member 144 extends from the proximal opening 121 of the housing 12, so as to facilitate the slender rod 26 to enter the channel 1440. The slender rod 26 passes through the channel 1440 and applies force to the locking portion 1462 located in the accommodating groove 1424a, causing the locking portion 1462 to deform and bend toward the distal end of the accommodating groove 1424a to escape from the restriction of the locking groove 123. At this time, the winding assembly 14 can rotate bidirectionally relative to the shell 12.

[0087] See also Fig.16 , Fig.17 , Fig.26 and Fig.33 In some embodiments, the radial length of the receiving groove 1424a gradually decreases from the proximal end to the distal end and the axial depth in the middle of the receiving groove 1424a is greater than the axial depth on both sides. It can be understood that the shape design of the receiving groove 1424a limits the two end portions of the locking portion 1462 from moving axially toward the distal end, which is conducive to applying force to the middle portion of the locking portion 1462 to deform the locking portion 1462 and bend toward the distal end of the receiving groove 1424a.

[0088] See also Figures 8 to 19 In some embodiments, the fixing seat 1424 is further provided with an axial hole 1424b communicating with the accommodating groove 1424a. The axial hole 1424b extends along the axial direction of the fixing seat 1424. The locking member 146 also includes a fixing shaft 1464 and a fixing pin 1466. The locking portion 1462 passes through the fixing shaft 1464 and is pressed by the fixing pin 1466. The fixing shaft 1464, the fixing pin 1466 and the locking portion 1462 are relatively fixed. The fixing shaft 1464 can be movably accommodated in the axial hole 1424b. It can be understood that in this embodiment, the locking portion 1462 is straight in a natural state, and both opposite ends thereof are free ends. The locking portion 1462 can be a straight elastic wire. The fixing shaft 1464 is provided with a mounting hole along its radial direction, and the locking portion 1462 passes through the mounting hole of the fixing shaft 1464 and is pressed by the fixing pin 1466. The fixing pin 1466 and the fixing shaft 1464 can be fixed by welding or gluing. The locking portion 1462 is accommodated in the accommodating groove 1424a, and the fixing shaft 1464 is accommodated in the accommodating hole, so that the locking member 146 can only move axially. After passing through the channel 1440 of the connecting member 144, the slender rod 26 can contact the fixing shaft 1464 of the locking member 146, and the external force is transmitted to the locking portion 1462 by applying force to the fixing shaft 1464, so that the locking portion 1462 is deformed. In some examples, the central axis of the axial hole 1424b is substantially coincident with the central axis of the winding member 142, so that the slender rod 26 accurately applies force to the middle part of the locking portion 1462.

[0089] Further, both opposite ends of the locking portion 1462 are locking ends 1462a. A plurality of locking grooves 123 are provided in the housing 12 along its circumference. Each locking end 1462a cooperates with one of the locking grooves 123 to limit the rotation of the winding assembly 14. It can be understood that when both opposite ends of the locking portion 1462 are locking ends 1462a, the number of locking grooves 123 provided in the housing 12 is an even number, thereby ensuring that when the winding assembly 14 stops rotating after rotating at any angle relative to the housing 12, both locking ends 1462a can enter the corresponding locking grooves 123.

[0090] In other embodiments, one of the two opposite ends of the locking portion 1462 is a locking end 1462a, and the other end is fixedly connected to the winding member 142 or the connecting member 144. In this way, the locking member 146 can omit the fixed shaft 1464 and the fixing pin 1466. The locking portion 1462 is straight in a natural state. The locking portion 1462 can be a linear elastic wire. One end of the locking portion 1462 is fixedly connected to the winding member 142 or the connecting member 144, and when assembling the winding assembly 14, the locking portion 1462 can be prevented from being offset relative to the winding member 142 and the connecting member 144, which is convenient for assembly. In this embodiment, a plurality of locking grooves 123 are provided in the housing 12 along its circumference. Since the locking portion 1462 is provided with a locking end 1462a, the locking grooves 123 provided in the housing 12 can be odd or even.

[0091] See also Figures 20 to 27 In some embodiments, the locking member 146 further includes a fixing portion 1468. One of the two opposite ends of the locking portion 1462 is a locking end 1462a, and the other end is fixedly connected to the fixing portion 1468. One of the fixing seat 1424 and the fixing portion 1468 is provided with a protrusion 1424c, and the other is provided with a matching groove 1468a adapted to the protrusion 1424c. The protrusion 1424c is accommodated in the matching groove 1468a. It can be understood that the shapes of the protrusion 1424c and the matching groove 1468a are adapted, and the fixing seat 1424 of the winding member 142 and the fixing portion 1468 of the locking member 146 are matched and connected through the protrusion 1424c and the matching groove 1468a. When assembling the winding assembly 14, the locking member 146 is first connected to the fixing seat 1424, and then the connecting member 144 is fixedly connected to the winding member 142. After the winding assembly 14 is assembled, the axial movement of the locking member 146 is restricted when the locking portion 1462 is not subjected to external force. In this embodiment, a plurality of locking grooves 123 are provided in the housing 12 along its circumference. Since the locking portion 1462 is provided with a locking end 1462a, the locking grooves 123 provided in the housing 12 can be odd or even.

[0092] In some examples, the fixing seat 1424 is provided with protrusions 1424c on both sides of the receiving groove 1424a, and the fixing portion 1468 is provided with a matching groove 1468a. In this example, the fixing portion 1468 and the locking portion 1462 can be made of the same elastic material. The fixing portion 1468 and the locking portion 1462 can be integrally formed, that is, the locking member 146 can be made of an elastic wire through heat setting. In other examples, the fixing seat 1424 is provided with matching grooves 1468a on both sides of the receiving groove 1424a, and the fixing portion 1468 is provided with a corresponding protrusion 1424c.

[0093] See also Figures 28 to 34In some embodiments, the locking member 146 further includes a fixing portion 1468. One of the two opposite ends of the locking portion 1462 is a locking end 1462a, and the other end is fixedly connected to the fixing portion 1468. The fixing seat 1424 is provided with a fixing groove 1424d adapted to the fixing portion 1468. The fixing portion 1468 is accommodated in the fixing groove 1424d. It can be understood that the shapes of the fixing portion 1468 and the fixing groove 1424d are adapted. In this embodiment, the fixing portion 1468 and the locking portion 1462 can be made of the same elastic material. The fixing portion 1468 and the locking portion 1462 can be integrally formed, that is, the locking member 146 can be made of an elastic wire through heat setting. When assembling the winding assembly 14, first place the fixing portion 1468 and the locking portion 1462 of the locking member 146 in the fixing groove 1424d and the receiving groove 1424a of the fixing seat 1424, respectively, and then fix the connecting member 144 to the winding member 142. After the winding assembly 14 is assembled, when the locking portion 1462 is not subjected to external force, the axial movement of the locking member 146 is restricted. In this embodiment, a plurality of locking grooves 123 are provided in the housing 12 along its circumference. Since the locking portion 1462 is provided with a locking end 1462a, the locking grooves 123 provided in the housing 12 can be odd or even.

[0094] In some embodiments, the fixing groove 1424d is provided on the outer peripheral wall of the fixing seat 1424. The fixing groove 1424d includes a first axial section 1424d1, a circumferential section 1424d2, and a second axial section 1424d3 which are connected in sequence. The second axial section 1424d3 is connected to the accommodating groove 1424a. In this way, the connection stability between the fixing portion 1468 and the fixing seat 1424 can be enhanced.

[0095] See also Figure 35 to Figure 37 , the embodiment of the present application further provides a locking system 300. The locking system 300 includes a delivery device 20 and a locking device 10 of any of the above embodiments. The delivery device 20 includes an outer tube 22, an inner tube 24 movably inserted into the outer tube 22, and a slender rod 26 movably inserted into the inner tube 24. The distal end of the outer tube 22 is connected to the housing 12 and is relatively fixed. The distal end of the inner tube 24 is connected to the connecting member 144 and is relatively fixed. Among them, the outer tube 22 is configured to limit the rotation of the housing 12, the slender rod 26 is configured to provide an external force to the locking member 146 to make the locking member 146 break away from the restriction of the housing 12, and the inner tube 24 is configured to drive the winding assembly 14 to rotate relative to the housing 12.

[0096] It can be understood that after the multiple anchoring members 50 connected by the flexible elongated member 30 are anchored to the valve ring, the locking device 10 connected to the distal end of the delivery device 20 is connected to the flexible elongated member 30, and then the elongated rod 26 is pushed to the distal end to apply force to the locking member 146 so that the locking member 146 is deformed and freed from the restriction of the housing 12, and then the inner tube 24 is rotated to drive the winding assembly 14 to rotate relative to the housing 12 to wind the flexible elongated member 30 around the winding member 142 to tighten the flexible elongated member 30 so that the spacing between the multiple anchoring members 50 is reduced to reduce the size of the patient's valve ring. After the valve ring is reduced to achieve the desired effect, the inner tube 24 is stopped from rotating to stop the winding assembly 14, and then the elongated rod 26 is withdrawn proximally, and the locking member 146 re-matches with the housing 12 due to its own elastic recovery shape, thereby locking the flexible elongated member 30. During the rotation of the inner tube 24, the outer tube 22 remains non-rotating to limit the rotation of the housing 12.

[0097] In some embodiments, the housing 12 is provided with a proximal opening 121. The connector 144 is provided with a channel 1440 extending along its axial direction. The channel 1440 runs through the proximal surface and the distal surface of the connector 144. The connector 144 includes a first connecting portion 1442 and a second connecting portion 1444 that are fixedly connected. The winding member 142 and the locking member 146 are integrally accommodated in the housing 12. The first connecting portion 1442 of the connector 144 is accommodated in the housing 12, and the second connecting portion 1444 extends from the proximal opening 121 of the housing 12, so as to be connected to the inner tube 24 of the conveying device 20. Specifically, the distal end of the inner tube 24 is movably sleeved on the second connecting portion 1444, and the inner tube 24 and the second connecting portion 1444 are relatively fixed. In one example, the second connecting portion 1444 is provided with at least one plane along the axial direction, and correspondingly, the distal portion of the inner tube 24 is provided with at least one plane. The inner tube 24 and the second connecting portion 1444 are limited in relative rotation by the plane. In another example, the inner tube 24 and the second connecting portion 1444 can limit the relative rotation between the inner tube 24 and the second connecting portion 1444 through the cooperation between the protrusion 5624 and the sliding groove.

[0098] See also Fig.37 and Fig.38In some embodiments, the elongated rod 26 includes a main body section 262 and a force-applying section 264 connected to the main body section 262. The force-applying section 264 is configured to press the locking member 146 in the channel 1440 of the connecting member 144 so that the locking member 146 is separated from the restriction of the housing 12. It can be understood that the elongated rod 26 passes through the channel 1440 of the connecting member 144 and contacts the locking member 146 disposed between the winding member 142 and the connecting member 144. The force-applying section 264 located in the channel 1440 presses the locking member 146 toward the distal end so that the locking member 146 is deformed and separated from the restriction of the housing 12. At this time, the winding assembly 14 can rotate bidirectionally relative to the housing 12. When the locking device 10 needs to be locked, the elongated rod 26 is removed, and the locking member 146 re-cooperates with the housing 12 due to its own elastic recovery shape (i.e., returns to the natural state) to limit the rotation of the winding assembly 14.

[0099] In some embodiments, at least the proximal portion of the channel 1440 of the connector 144 is provided with an internal thread, and the force-applying section 264 is correspondingly provided with an external thread. A first annular projection 240 is provided in the inner cavity of the inner tube 24, and a second annular projection 260 is provided on the slender rod 26. After the distal end of the inner tube 24 is connected to the connector 144 and the force-applying section 264 of the slender rod 26 is threadedly connected to the channel 1440, the second annular projection 260 limits the first annular projection 240 from moving toward the proximal end. It can be understood that the force-applying section 264 of the slender rod 26 is threadedly connected to the channel 1440 of the connector 144. On the one hand, the slender rod 26 can move axially relative to the channel 1440 through a spiral transmission, and on the other hand, the threaded connection can ensure the stability of the connection between the slender rod 26 and the connector 144. The second annular projection 260 limits the first annular projection 240 from moving toward the proximal end, so that the inner tube 24 and the connector 144 can remain connected.

[0100] It can be understood that since the slender rod 26 is threadedly connected to the connecting piece 144, the inner tube 24 is movably sleeved on the connecting piece 144, and in the process of driving the winding assembly 14 to rotate relative to the housing 12, the inner tube 24 and the slender rod 26 rotate synchronously to drive the winding assembly 14 to rotate. In this way, on the one hand, it can be avoided that the threaded connection between the slender rod 26 and the connecting piece 144 is released in advance when the ideal surgical effect is not achieved, and the slender rod 26 continuously applies pressure to the locking piece 146, so that the locking device 10 remains unlocked, and the inner tube 24 and the connecting piece 144 are always sleeved, so that the winding assembly 14 can be stably driven to rotate and the flexible slender piece 30 can be wound around the winding piece 142, thereby improving the stability of the surgical operation; on the other hand, it can be avoided that the threaded connection between the connecting rod and the connecting piece 144 is tightened and becomes hard to release, thereby improving the safety and reliability of the surgery.

[0101] See also Fig.36In some embodiments, the outer tube 22 includes an outer tube body 222 and a connecting claw 224 fixedly disposed at the distal end of the outer tube body 222. The housing 12 is correspondingly provided with a connecting groove 127 adapted to the connecting claw 224. The outer tube 22 and the housing 12 are connected and relatively fixed by the cooperation between the connecting claw 224 and the connecting groove 127. The number of the connecting claws 224 can be one or more, and the number of the connecting grooves 127 is consistent with the number of the connecting claws 224. In one example, the number of the connecting claws 224 is two, and the two connecting claws 224 are fixedly connected to the distal end of the outer tube body 222 and are arranged opposite to each other. Correspondingly, the housing 12 is provided with two connecting grooves 127.

[0102] See also Figure 2 and Figure 39 to Figure 41 The working principle of the locking device 10 of the embodiment of the present application is described below by taking the locking device 10 applied to mitral annuloplasty as an example. The surgical path of mitral annuloplasty is: femoral vein-inferior vena cava-right atrium (RA)-atrial septum (AS)-left atrium (LA)-mitral valve annulus (MVA).

[0103] See also Fig.39 , sequentially from the anterior triangular area of ​​the mitral valve along the posterior valve ring to the posterior triangular area or in the reverse direction, a sufficient number of anchors 50 are implanted in the mitral valve ring. Among them, the distal end of the flexible slender member 30 is connected to the first anchor 50, and the proximal end of the flexible slender member 30 is connected to the distal end of the conveying member 200 in a U-shaped manner. The remaining anchors 50 are transported to the flexible slender member 30 by the conveying member 200 before implantation, so as to be movably connected with the flexible slender member 30. Two adjacent anchors 50 are provided with a spacer 70, and the distance between the two adjacent anchors 50 is greater than the axial length of the spacer 70.

[0104] Please refer to the figure combination Fig.40 and Fig.41, the locking device 10 is pre-connected to the distal end of the conveying device 20. First, the proximal end of the conveying member 200 is sequentially passed through the first through hole 125, the second through hole 1420 on one side of the locking device 10, and the second through hole 1420 on the other side, and the locking device 10 is conveyed to the flexible slender member 30 along the conveying member 200, and the locking device 10 is close to the last anchoring member 50. Then, the slender rod 26 is rotated to move the slender rod 26 toward the distal end through the spiral transmission, and a force is applied to the locking portion 1462 to deform the locking portion 1462 and bend toward the distal end of the accommodating groove 1424a, and the locking end 1462a is retracted along the radial direction of the accommodating groove 1424a, and the locking end 1462a is free from the restriction of the locking groove 123 of the housing 12, and the winding assembly 14 can rotate bidirectionally relative to the housing 12. Next, the outer tube 22 is fixed, and the inner tube 24 and the slender rod 26 are rotated clockwise to rotate the winding assembly 14 relative to the housing 12 so that the flexible slender member 30 is wound around the winding member 142. After the flexible slender member 30 is wound around the winding member 142 for at least two turns, the conveying member 200 is pulled out of the body. The regurgitation of the mitral valve is observed by ultrasound. If the regurgitation amount of the mitral valve has not been reduced to the ideal state, the inner tube 24 and the slender rod 26 are continued to be rotated clockwise to further tighten the flexible slender member 30. If the flexible slender member 30 is over-tightened and causes stenosis of the mitral valve, the inner tube 24 and the slender rod 26 are rotated counterclockwise to release part of the flexible slender member 30. During the operation, the clockwise and counterclockwise rotations (if necessary) of the winding assembly 14 are controlled until a good ring shrinking effect is achieved. Finally, the threaded connection between the slender rod 26 and the connecting member 144 is released, and the locking portion 1462 re-matches with the housing 12 due to its own elastic recovery shape, thereby locking the flexible slender member 30. The flexible slender member 30 wound around the winding member 142 will make the locking device 10 and the last anchoring member 50 in a close contact state by relying on friction.

[0105] It should be noted that, in the absence of conflict, the embodiments and features in the embodiments of the present application can be combined with each other, and any combination of features in different embodiments is also within the protection scope of the present application. That is to say, the multiple embodiments described above can also be arbitrarily combined according to actual needs.

[0106] It should be noted that all the above drawings are illustrative illustrations of the present application and do not represent the actual size of the product. Moreover, the size ratio relationship between the components in the drawings is not intended to limit the actual product of the present application.

[0107] The above are only some of the embodiments and implementations of the present application, and the protection scope of the present application is not limited thereto. Any person skilled in the art who is familiar with the technical scope disclosed in the present application can easily think of changes or substitutions, which should be included in the protection scope of the present application. Therefore, the protection scope of the present application shall be based on the protection scope of the claims.

Claims

1. A locking device, characterized in that: include: case; and A winding assembly at least partially accommodated in the housing, the winding assembly being rotatable relative to the housing, the winding assembly comprising a winding member, a connecting member and a locking member, the locking member being elastic, the locking member being arranged between the winding member and the connecting member, and the winding member being fixedly connected to the connecting member; The locking member cooperates with the housing to limit the rotation of the winding assembly, and the locking member is configured to be able to break away from the restriction of the housing under the action of external force.

2. The locking device according to claim 1, characterized in that: The locking member includes an elastic locking portion, which is in the shape of an elongated strip and includes two opposite ends, at least one of the two opposite ends being a locking end, and at least one locking groove is provided in the shell along its circumference, and the locking end cooperates with one of the locking grooves to limit the rotation of the winding assembly, and the locking portion is configured to enable the locking end to escape from the restriction of the locking groove under the action of an external force.

3. The locking device according to claim 2, characterized in that: The winding member comprises a bobbin and a fixing seat fixedly connected to the bobbin, the connecting member is fixedly connected to the fixing seat, the fixing seat is provided with a receiving groove, and the locking portion is received in the receiving groove; When the locking portion is in a natural state, the locking end extends out of the accommodating groove and cooperates with one of the locking grooves; When the locking portion is subjected to an external force, the locking portion is deformed to cause the locking end to retract toward the accommodating groove, and the locking end is freed from the restriction of the locking groove.

4. The locking device according to claim 3, characterized in that: The connecting member includes a first connecting portion, the fixing seat is fixedly accommodated in an inner cavity of the first connecting portion, and the first connecting portion is provided with an avoidance groove corresponding to the accommodating groove.

5. The locking device according to claim 4, characterized in that: The shell is provided with a proximal opening, and the connecting member further comprises a second connecting portion fixedly connected to the first connecting portion, and the second connecting portion extends from the proximal opening.

6. The locking device according to claim 3, characterized in that: The radial length of the accommodating groove gradually decreases from the proximal end to the distal end and the axial depth in the middle of the accommodating groove is greater than the axial depths on both sides.

7. The locking device according to any one of claims 3 to 6, characterized in that: The fixing seat is also provided with an axial hole connected to the accommodating groove, and the axial hole extends along the axial direction of the fixing seat. The locking member also includes a fixing shaft and a fixing pin. The locking portion passes through the fixing shaft and is tightened by the fixing pin. The fixing shaft, the fixing pin and the locking portion are relatively fixed, and the fixing shaft can be movably accommodated in the axial hole.

8. The locking device according to claim 7, characterized in that: The two opposite ends are both locking ends. A plurality of locking grooves are arranged in the shell along its circumference. Each locking end cooperates with one of the locking grooves to limit the rotation of the winding assembly.

9. The locking device according to any one of claims 3 to 6, characterized in that: The locking member also includes a fixing portion, one of the two opposite ends being the locking end, and the other end being fixedly connected to the fixing portion, one of the fixing seat and the fixing portion being provided with a protrusion, and the other being provided with a matching groove adapted to the protrusion, and the protrusion being accommodated in the matching groove.

10. The locking device according to any one of claims 3 to 6, characterized in that: The locking member also includes a fixing portion, one of the two opposite ends is the locking end, and the other end is fixedly connected to the fixing portion, the fixing seat is provided with a fixing groove adapted to the fixing portion, and the fixing portion is accommodated in the fixing groove.

11. The locking device according to claim 10, characterized in that: The fixing groove is arranged on the outer peripheral wall of the fixing seat, and the fixing groove comprises a first axial section, a circumferential section and a second axial section which are connected in sequence, and the second axial section is connected to the containing groove.

12. The locking device according to claim 2, characterized in that: The surface of the locking groove includes a blocking surface, a guiding surface, and a transition surface connecting the blocking surface and the guiding surface, and the transition surface is arc-shaped; Wherein, when the locking portion is in a natural state, the locking end is located in one of the locking grooves, and the stop portion is substantially parallel to the blocking surface.

13. The locking device according to claim 1, characterized in that: The shell is provided with a first through hole, and the winding member is provided with a second through hole. The first through hole and the second through hole are configured to allow a flexible slender member to pass through. The winding assembly is configured to rotate relative to the shell to wind the flexible slender member onto the winding member or release the flexible slender member from the winding member.

14. The locking device according to claim 1, characterized in that: The shell is provided with a proximal opening, and the connecting piece is provided with a channel extending along its axial direction, the channel passes through the proximal surface and the distal surface of the connecting piece, the channel is exposed to the proximal opening, and the channel is configured to allow a slender rod to pass through, and the locking piece is released from the restriction of the shell in response to a force applied thereto by the slender rod.

15. A locking system, characterized in that: The invention comprises a conveying device and a locking device according to any one of claims 1 to 14, wherein the conveying device comprises an outer tube, an inner tube movably inserted in the outer tube, and a slender rod movably inserted in the inner tube, wherein the distal end of the outer tube is connected to the housing and is relatively fixed, and the distal end of the inner tube is connected to the connecting piece and is relatively fixed; The outer tube is configured to limit the rotation of the shell, the slender rod is configured to provide external force to the locking element to make the locking element break away from the restriction of the shell, and the inner tube is configured to drive the winding assembly to rotate relative to the shell.

16. The locking system according to claim 15, characterized in that The connecting member is provided with a channel extending along its axial direction, and the channel passes through the proximal surface and the distal surface of the connecting member. The slender rod includes a main body section and a force-applying section connected to the main body section, and the force-applying section is configured to press the locking member in the channel to make the locking member break away from the restriction of the shell.

17. The locking system according to claim 16, characterized in that At least the proximal portion of the channel is provided with an internal thread, the force-applying section is correspondingly provided with an external thread, a first annular protrusion is provided in the inner cavity of the inner tube, and a second annular protrusion is provided on the slender rod; Wherein, after the distal end of the inner tube is connected to the connecting piece and the force-applying section of the slender rod is threadedly connected to the channel, the second annular protrusion restricts the first annular protrusion from moving toward the proximal end.

18. An implant, characterized in that It comprises a flexible slender member, a plurality of anchor members and a locking device according to any one of claims 1 to 14, wherein the flexible slender member connects the plurality of anchor members and the locking device, each of the anchor members is configured to be anchored to tissue, the flexible slender member is configured to adjust the spacing between the plurality of anchor members, and the locking device is configured to adjust the length of the flexible slender member and lock the length of the flexible slender member.

19. The implant according to claim 18, characterized in that The implant further comprises at least one spacer, which is movably connected to the flexible elongated member and is disposed between two adjacent anchoring members.

20. The implant according to claim 18, characterized in that The anchor member includes a tissue engaging element, a head and a connecting structure, wherein the head is connected to the proximal end of the tissue engaging element, and the connecting structure can be rotatably mounted on the head or the proximal end portion of the tissue engaging element, and the connecting structure is provided with a connecting hole, and the connecting hole is configured for the flexible slender member to pass through, and a fixing member is provided at the distal end of the flexible slender member, and the fixing member is located on the distal side of the connecting hole of the first anchor member, and the fixing member is connected to the connecting structure to limit the proximal movement of the first anchor member relative to the flexible slender member.

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