Sample blending device and blending method

Abstract

The invention discloses a sample mixing device and a mixing method.The sample mixing device comprises a sample mixing pipe, the first end of the sample mixing pipe is open and used for extracting a reagent or air, the second end of the sample mixing pipe is connected with a pump body, and when the first end of the sample mixing pipe extracts air, the second end of the sample mixing pipe is connected with the pump body; and the air can extrude the residual reagent in the sample mixing pipe towards the second end of the sample mixing pipe to form a clean section, and the reagent can be uniformly mixed when the reagent to be mixed is repeatedly sucked in the clean section under the action of the pump body. The uniform mixing method adopts the sample uniform mixing device. The device is reasonable in structure, good in uniform mixing effect and small in operation space, the risk of impurity mixing can be greatly reduced, and the accuracy of a detection result can be improved.

Description

Technical Field

[0001] The invention relates to the technical field of sample injection equipment, in particular to a sample mixing device and a mixing method. Background Art

[0002] A sampler is a device used to introduce samples into an analytical instrument or processing system. It is widely used in laboratory analysis, chemical production, pharmaceuticals, environmental monitoring and other fields. When the sampler dilutes the stock solution to prepare the standard solution, whether the standard solution is mixed evenly has a great impact on the calibration instrument or ensuring the accuracy of the analysis results. In practice, the sampler has a precise structure and a small operating space. In the prior art, the bubbling method is usually used to mix the diluted stock solution to prepare the standard solution, that is, inject air or other gases into the diluted stock solution to make the diluted stock solution roll to prepare the standard solution. The size of the bubbles must also be controlled to avoid bubbles that are too large or too small, which has a certain degree of operating difficulty, especially when the amount of diluted stock solution is small; in addition, the air and other gases that are blown in also have the risk of introducing impurities into the stock solution, which is not conducive to improving the accuracy and repeatability of the test data. Summary of the invention

[0003] The present invention discloses a sample mixing device and a mixing method, which solves the technical problems of poor mixing effect and easy introduction of impurities in the existing sample injector using the bubbling method for mixing, and has the technical effects of reasonable structure, good mixing effect, small operation space, greatly reducing the risk of mixing impurities and being conducive to improving the accuracy of detection results. The adopted technical scheme is as follows: A sample mixing device comprises a mixing tube, wherein the first end of the mixing tube is open and used for extracting reagents or air, and the second end of the mixing tube is connected to a pump body. When the first end of the mixing tube extracts air, the air can expel the residual reagent in the mixing tube toward the second end of the mixing tube to form a clean section. When the reagent to be mixed is repeatedly sucked in the clean section under the action of the pump body, the reagent can be mixed.

[0004] On the basis of the above technical solution, the first end of the sample mixing tube includes a sampling needle, and the end of the sampling needle includes a spike portion.

[0005] On the basis of the above technical solution, the sample mixing tube is provided with scale values, and the pump body includes a syringe pump.

[0006] On the basis of the above technical solution, it also includes a driving unit, which is used to drive the mixing tube to move.

[0007] A mixing method, using the sample mixing device as described above, comprises the following steps: A. Clean the sample mixing tube with cleaning solution; B. Under the action of the pump body, the first end of the mixing tube absorbs the original solution and injects the original solution into the sample bottle; C. Under the action of the pump body, the first end of the mixing tube injects the diluent into the sample bottle to form the reagent to be mixed; D. Make the first end of the mixing tube contact with the air, and under the action of the pump body, extract a certain amount of air through the first end of the mixing tube. The certain amount of air is designed so that the air can expel the residual reagent in the mixing tube to the second end of the mixing tube to form a clean section. In this application, the clean section is a relative concept, which refers to the mixing tube section where residual liquid is accumulated. A small amount of residual liquid may also be attached to the clean section.

[0008] E. Make the first end of the mixing tube contact the reagent in the sample bottle, and under the action of the pump body, repeatedly draw the reagent in the clean section to mix the mixed liquid. During the repeated drawing process, the suction force of the pump body changes accordingly. In addition, in the present application, the length of the clean section extending in the mixing tube is elastically variable. When the suction force of the pump body increases, the length of the clean section extends and is filled with the mixed liquid; when the suction force of the pump body decreases, the length of the clean section decreases, and the level of the mixed liquid filled therein decreases.

[0009] On the basis of the above technical solution, the cleaning liquid adopts pure water; the diluent adopts pure water.

[0010] On the basis of the above technical solution, a multi-way valve is provided at the inlet end of the sample mixing tube.

[0011] Based on the above technical solution, after the cleaning liquid cleans the mixing tube, the first end of the mixing tube is brought into contact with air. Under the action of the pump body, a certain amount of air is extracted through the first end of the mixing tube, and the air discharges the cleaning liquid in the mixing tube to the second end of the mixing tube.

[0012] On the basis of the above technical solution, under the action of the pump body, the reagent is repeatedly sucked 3 to 6 times in the clean section to mix the mixed liquid.

[0013] On the basis of the above technical solution, the outer cover of the mixing device is provided with a shell, and a filter is provided at the inlet of the shell that is connected to the outside air.

[0014] Beneficial Effects The present invention has a reasonable structure. Before the mixing operation, air is quantitatively extracted through the first end of the mixing tube, and the air flow flows rapidly in the mixing tube, prompting the residual reagent in the mixing tube to flow to the second end of the mixing tube, so that a clean section can be formed near the first end of the mixing tube, and then when the mixing tube is operated in the next step, the degree of crossover between reagents is reduced, which is conducive to more accurate control of the concentration or injection volume of the reagent. When performing the mixing operation, the diluted stock solution is repeatedly sucked in the clean section, so that the stock solution and the diluent can be more violently stirred, which is conducive to improving the mixing effect of the mixed standard solution, and at the same time avoiding the operational difficulties of controlling the size of bubbles in the bubbling method; in addition, in the aforementioned mixing operation, the reagent to be mixed always seals the air in the mixing tube in the mixing tube, that is, the reagent to be mixed is in contact with the air in the cross-sectional area of ​​the mixing tube, which greatly reduces the contact degree between the mixed solution and the air compared to the bubbling method, and is conducive to reducing the risk of impurities being mixed in.

[0015] The invention has a simple structure and a small operating space, and can effectively solve the mixing problem in a small space, can better meet the use requirements, and at the same time avoids the introduction of impurities, which is beneficial to improving the accuracy of detection. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the prior art descriptions are briefly introduced below. Obviously, the drawings described below are only one embodiment of the present invention, and for ordinary technicians in this field, other implementation drawings can be derived from the provided drawings without creative work.

[0017] Figure 1 : Schematic diagram of the structure in which the air pushes the residual liquid in the mixing tube toward the second end of the mixing tube; Figure 2 :The mixing tube repeatedly draws the mixed liquid Figure 1 ; Figure 3 :The mixing tube repeatedly draws the mixed liquid Figure 2 ; DETAILED DESCRIPTION The following description and accompanying drawings fully illustrate the specific embodiments of this article so that those skilled in the art can practice them. Parts and features of some embodiments may be included in or replace parts and features of other embodiments. The scope of the embodiments of this article includes the entire scope of the claims, as well as all available equivalents of the claims. Herein, the terms "first", "second", etc. are only used to distinguish one element from another, without requiring or implying any actual relationship or order between these elements. In fact, the first element can also be called the second element, and vice versa. Moreover, the terms "include", "comprise" or any other variant thereof are intended to cover non-exclusive inclusion, so that the structure, device or equipment including a series of elements includes not only those elements, but also other elements that are not explicitly listed, or also include elements inherent to such structure, device or equipment. In the absence of more restrictions, the elements defined by the sentence "including one..." do not exclude the existence of other identical elements in the structure, device or equipment including the elements. Each embodiment is described in a progressive manner herein, and each embodiment focuses on the differences from other embodiments, and the same and similar parts between the embodiments can be referred to each other.

[0018] The terms "longitudinal", "lateral", "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc. in this document indicate the orientation or position relationship based on the orientation or position relationship shown in the drawings, and are only for the convenience of describing this document and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operate in a specific orientation, and therefore cannot be understood as a limitation on the present invention. In the description of this document, unless otherwise specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a mechanical connection or an electrical connection, it can also be the internal communication of two elements, it can be a direct connection, or it can be an indirect connection through an intermediate medium. For ordinary technicians in this field, the specific meanings of the above terms can be understood according to specific circumstances.

[0019] As used herein, the term "plurality" means two or more than two, unless otherwise specified.

[0020] In this document, the character " / " indicates that the preceding and following objects are in an "or" relationship. For example, A / B means: A or B.

[0021] In this article, the term "and / or" is a description of the association relationship between objects, indicating that three relationships may exist. For example, A and / or B means: A or B, or, A and B.

[0022] Example 1 like Figures 1 to 3 The sample mixing device shown includes a sample mixing tube 100 . The first end of the sample mixing tube 100 includes a sampling needle. The end of the sampling needle includes a sharp thorn portion to facilitate piercing the stopper on the sample bottle 200 .

[0023] like Figure 2 and 3 As shown, the spiked portion of the mixing tube 100 forms the first end, and the first end of the mixing tube 100 is open for extracting reagents or air. In this embodiment, the reagent here can be a stock solution, or a mixture of a stock solution and a diluent, which are collectively referred to as reagents for the convenience of description. The stock solution is a high-concentration solution that has not been diluted or treated, and is often used as a basis for preparing other solutions. The diluent is used to adjust the high-concentration stock solution to a concentration suitable for experiment or analysis to avoid instrument overload or analysis error caused by excessive concentration.

[0024] The second end of the mixing tube 100 is connected to the pump body. In this embodiment, the pump body includes a syringe pump, and a multi-way valve is provided on the hose connecting the second end of the mixing tube 100 to the pump body. The multi-way valve is electrically connected to the external controller.

[0025] like Figure 1 As shown, when a certain amount of air is drawn from the first end of the mixing tube 100, the air can push the residual reagent in the mixing tube 100 toward the second end of the mixing tube 100. In this embodiment, the reagent here can be a cleaning solution, a diluent, or a mixture of a diluent and an original solution. For the convenience of description, they are collectively referred to as residual reagents. Under the action of the pressure difference between the inside and outside of the mixing tube 100, a clean section is formed. When the reagent is repeatedly sucked in the clean section under the action of the pump body, the reagent can be mixed, such as Figure 2 and 3 As shown. During the repeated suction process, the suction force of the pump body changes accordingly. In addition, during the suction process, the length of the clean section extending in the mixing tube 100 changes elastically. When the suction force of the pump body increases, the length of the clean section extends and is filled with the mixed liquid; when the suction force of the pump body decreases, the length of the clean section decreases, and the level of the mixed liquid filled therein decreases.

[0026] The sample mixing tube 100 is provided with scale values ​​(not shown) to facilitate identification of the amount of air inhaled by the sample mixing tube 100 .

[0027] In addition, a driving unit is included, and the driving unit is used to drive the sample mixing tube 100 to move. A mixing method, using the above sample mixing device, comprises the following steps: A. Cleaning the sample mixing tube 100 with a cleaning liquid. In this embodiment, the cleaning liquid is pure water. The method and device for cleaning the sampling needle with the cleaning liquid are prior art and will not be described in detail here. B. The driving unit drives the sampling needle to move downward, so that the sampling needle pierces the sample bottle storing the stock solution, and then under the action of the pump body, the first end of the sampling needle absorbs the stock solution and injects the stock solution into the sample bottle 200 containing the mixed solution; C. Afterwards, the multi-way valve is switched, and under the action of the pump body, the diluent flows through the mixing tube 100, and the diluent is injected into the sample bottle 200 from the first end of the mixing tube to form a reagent to be mixed. In this embodiment, the diluent is pure water; in this process, the diluent flushes the inner wall surface of the sampling needle, so that most of the original liquid attached to it enters the sample bottle 200.

[0028] D. Then the driving unit drives the mixing tube 100 to separate from the sample bottle, so that the first end of the mixing tube 100 contacts the air, and the multi-way valve is switched. Under the action of the pump body, a certain amount of air is extracted through the first end of the mixing tube 100, and the air pushes the diluent or the mixture of the diluent and the original solution remaining in the mixing tube 100 toward the second end of the mixing tube, forming a clean section; E. Afterwards, the driving unit drives the mixing tube 100 to extend below the liquid surface of the mixed liquid of the diluent and the original liquid to be mixed in the sample bottle, that is, the first end of the mixing tube 100 contacts the reagent in the sample bottle, and the multi-way valve is switched. Under the action of the pump body, the mixed liquid reagent to be mixed is repeatedly sucked in the clean section to mix the mixed liquid. Figure 2 and 3 In the clean section, the reagent is repeatedly pumped 3 to 6 times for a good mixing effect.

[0029] In addition, the outer cover of the mixing device is provided with a shell, and a filter is provided at the inlet of the shell that is connected to the outside air to filter out impurities in the air, which is beneficial to reduce impurities mixed in the mixed liquid and thus improve the accuracy of the detection results.

[0030] Example 2 The difference between Example 2 and Example 1 is that, in the mixing method, in order to prevent the residual cleaning liquid in the mixing tube 100 from mixing into the original solution, after the cleaning liquid cleans the mixing tube 100, the driving unit drives the mixing tube 100 to move, so that the first end of the mixing tube 100 contacts the air, and then the multi-way valve is switched. Under the action of the pump body, a certain amount of air is extracted through the first end of the mixing tube 100, and the air discharges the cleaning liquid in the mixing tube to the second end of the mixing tube, which is beneficial to further improve the concentration accuracy of the standard solution prepared by the original solution and the diluent.

[0031] The present invention is described above by way of examples, but the present invention is not limited to the above specific embodiments, and any changes or modifications made based on the present invention belong to the scope of protection claimed by the present invention.

Claims

1. A sample mixing device, characterized in that: The invention comprises a mixing tube (100), wherein the first end of the mixing tube (100) is open and used for extracting reagents or air, and the second end of the mixing tube (100) is connected to a pump body. When the first end of the mixing tube (100) extracts air, the air can expel the residual reagent in the mixing tube toward the second end of the mixing tube (100) to form a clean section. When the reagent to be mixed is repeatedly sucked in the clean section under the action of the pump body, the reagent can be mixed.

2. The sample mixing device according to claim 1, characterized in that: The first end of the sample mixing tube (100) comprises a sampling needle, and the end of the sampling needle comprises a sharp thorn portion.

3. The sample mixing device according to claim 1 or 2, characterized in that: The sample mixing tube is provided with scale values, and the pump body comprises a syringe pump.

4. The sample mixing device according to claim 3, characterized in that: It also comprises a driving unit, wherein the driving unit is used to drive the sample mixing tube (100) to move.

5. A mixing method, using the sample mixing device as claimed in any one of claims 1, 2, and 4, characterized in that: The steps include: A. Cleaning solution to clean the sample mixing tube (100); B. Under the action of the pump body, the first end of the sample mixing tube (100) absorbs the stock solution and injects the stock solution into the sample bottle (200); C. Under the action of the pump body, the first end of the mixing tube injects the diluent into the sample bottle (2100) to form the reagent to be mixed; D. bringing the first end of the sample mixing tube (100) into contact with air, and under the action of the pump body, extracting a certain amount of air through the first end of the sample mixing tube (100), and the air displaces the residual reagent in the sample mixing tube (100) toward the second end of the sample mixing tube (100), thereby forming a clean section; E. The first end of the sample mixing tube (100) is brought into contact with the reagent in the sample bottle, and the reagent is repeatedly pumped into the clean section under the action of the pump body to mix the mixed liquid.

6. The mixing method according to claim 5, characterized in that: The cleaning liquid is pure water; the diluent is pure water.

7. The mixing method according to claim 6, characterized in that: A multi-way valve is provided at the inlet end of the sample mixing tube (100).

8. The mixing method according to claim 5, characterized in that: After the sample mixing tube (100) is cleaned with the cleaning liquid, the first end of the sample mixing tube (100) is brought into contact with air, and under the action of the pump body, a fixed amount of air is extracted through the first end of the sample mixing tube (100), and the air discharges the cleaning liquid in the sample mixing tube (100) toward the second end of the sample mixing tube (100).

9. The mixing method according to claim 8, characterized in that: Under the action of the pump body, the reagent is repeatedly pumped 3 to 6 times in the clean section to mix the mixed liquid.

10. The mixing method according to any one of claims 5 to 9, characterized in that: The outer cover of the mixing device is provided with a shell, and the inlet of the shell connected with the outside air is provided with a filter.

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