The invention relates to a production method of wet phosphoric acid byproducts comprising highly pure and highly white alpha-semi-hydrated gypsum and an inorganic-organic compound fertilizer. The method comprises the following steps: carrying out an acidolysis reaction on phosphoric acid and phosphate rock powder, adding a filter aid to a mixed slurry obtained after the reaction, carrying out solid-liquid separation, washing the obtained solid phase to obtain washing water and a solid, crushing the solid, sending the crushed solid into a granulator, reacting the crushed solid with gasified ammonia in the granulator, adding fertilizers with different formulas, granulating, drying the granulated material, screening, cooling, and packaging to obtain the inorganic-organic compound fertilizer; and introducing a clear liquid obtained after the acidolysis and solid-liquid separation into a decalcification and crystal transformation tank, adding a sulfuric acid solution and a crystal transformation agent, carrying out decalcification and crystal transformation reactions, carrying out solid-liquid separation to obtain a solid and a clear liquid, adding the solid into hot water, washing, and drying to obtain the highly pure and highly white alpha-semi-hydrated gypsum. The highly pure and highly white alpha-semi-hydrated gypsum with the advantages of excellent performances, white appearance and wide uses can be produced, and the inorganic-organic compound fertilizer can be produced by using organic matters, phosphorus and resources residual in acid insoluble substances.