An assisted injection platform for endothelial response testing

Abstract

The application relates to an auxiliary injection platform for an endothelial reaction test, which comprises a base assembly, an X-direction sliding rail arranged on the upper side of the base, an X-direction sliding block in sliding connection with the X-direction sliding rail, a Y-direction sliding rail assembly, a Y-direction support frame fixedly connected with the base, a Y-direction sliding rail arranged on the Y-direction support frame, a Z-direction sliding rail assembly, a Y-direction sliding block in sliding connection with the Y-direction sliding rail, a Z-direction sliding rail arranged on the rear end face of the Y-direction sliding block, a Z-direction sliding block in sliding connection with the Z-direction sliding rail, an injector assembly fixedly connected with the Z-direction sliding block, and a driving assembly capable of driving the X-direction sliding block, the Y-direction sliding block and the Z-direction sliding block to move along the X-direction, the Y-direction and the Z-direction respectively. The auxiliary injection device can automatically complete the endothelial injection process of continuous and multi-point injection on test animals in the endothelialization test process, and the labor intensity of the operator is reduced.

Description

Technical Field

[0001] This invention relates to the field of medical devices, and in particular to an auxiliary injection platform for endothelial reactions. Background Technology

[0002] Interventional medical devices, such as vascular stents, occluders, or filters, may contain various chemical components after the manufacturing process, such as dyes, adhesives, and sterilization residues from the sterilization process. The potential irritant activity of these components should be considered. Irritation is characterized by inflammation, redness, swelling, heat, and pain. Therefore, irritation testing is crucial for assessing the potential for irritation after exposure of interventional medical devices to the human body.

[0003] To assess the extent of irritation to the human body caused by interventional medical devices, irritation testing is required. Endothelial reaction testing is a routine method for irritation testing, assessing the likelihood of irritation by intradermal injection of an extract of the medical device. During the test, multiple injections are performed at specific sites on the experimental animal. For example, multiple injections of the extract are made at equal intervals along the longitudinal direction (head to tail) on the left side of the rabbit's spine, and multiple injections of the control solution are made at equal intervals along the longitudinal direction on the right side of the rabbit's spine, with each injection point on the left side aligned with the injection point on the right side. Therefore, endothelial reaction testing requires multiple injections on the experimental animal, and the location of the injection points is highly critical. Currently, manual injection is commonly used, which is highly demanding on the operator and physically demanding. Summary of the Invention

[0004] Based on this, and to address the aforementioned problems, the present invention provides an auxiliary injection platform for endothelial reaction testing, capable of fully automated injection to replace the manual injection process. This auxiliary injection device includes: a base assembly comprising a base and an X-axis slide rail disposed on the upper side of the base; an X-axis slider slidably connected to the X-axis slide rail; a Y-axis slide rail assembly comprising a Y-axis support frame fixedly connected to the base, with a Y-axis slide rail disposed on the Y-axis support frame; a Z-axis slide rail assembly comprising a Y-axis slider and a Z-axis slide rail disposed on the rear end face of the Y-axis slider, with the Y-axis slider slidably connected to the Y-axis slide rail; a Z-axis slider slidably connected to the Z-axis slide rail; a syringe assembly fixedly connected to the Z-axis slider; and a drive assembly capable of driving the X-axis slider, Y-axis slider, and Z-axis slider to move along the X, Y, and Z axes, respectively.

[0005] Furthermore, it also includes an injection pre-compression component. The syringe assembly includes an injection needle, and the injection pre-compression component includes a telescopic connecting rod assembly and a pre-compression ring. One end of the connecting rod assembly is fixedly connected to the Z-axis slider, and the other end is fixedly connected to the pre-compression ring. The injection needle can pass through the pre-compression ring.

[0006] Furthermore, the longitudinal axis of the injection needle is substantially parallel to or coincides with the central axis of the pre-compression ring.

[0007] Furthermore, a pressure sensor is provided on the lower end face of the preload ring.

[0008] Furthermore, a sterilization component is provided on the lower end face of the pre-compression ring.

[0009] Furthermore, the connecting rod assembly includes a first connecting rod, a second connecting rod, and a third connecting rod connected in sequence. The free end of the first connecting rod is fixedly connected to the X-axis slider, and the third connecting rod is fixedly connected to the preload ring b.

[0010] Furthermore, the second connecting rod includes a first rod unit and a second rod unit that are slidably connected to each other, and an elastic element is provided between the opposite end faces of the first rod unit and the second rod unit.

[0011] Furthermore, it also includes a first reinforcing rod and a second reinforcing rod. One end of the first reinforcing rod is connected to the first connecting rod, and the other end is connected to the first rod unit. One end of the second reinforcing rod is connected to the third connecting rod, and the other end is connected to the second rod unit.

[0012] Furthermore, the longitudinal axis of the second connecting rod is substantially parallel to the central axis of the preload ring.

[0013] Furthermore, a camera is also provided on the injection pre-compression component.

[0014] The technical solution of the present invention has the following beneficial effects:

[0015] 1. The injection needle of the present invention has three degrees of freedom (X, Y, and Z) relative to the X-axis slider on which the test animal is placed, thereby enabling fully automated operation of multi-point injection of the injection needle into the test animal, reducing the requirements for test operators, reducing the workload of test operators, and improving the success rate of multiple injections. Attached Figure Description

[0016] Figure 1 A three-dimensional structural diagram of the auxiliary injection device;

[0017] Figure 2 A three-dimensional structural diagram of the auxiliary injection device without the base, etc.;

[0018] Figure 3 This is a first partial perspective view of the auxiliary injection device;

[0019] Figure 4 This is a second partial perspective view of the auxiliary injection device;

[0020] Figure 5for Figure 1 Enlarged view of point A in the image;

[0021] Figure 6 This is a partial sectional view of the second connecting rod;

[0022] Figure 7 A partial exploded view of the auxiliary injection device; Detailed Implementation

[0023] To make the above-mentioned objects, features, and advantages of the present invention more apparent and understandable, specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings. Many specific details are set forth in the following description to provide a thorough understanding of the present invention. However, the present invention can be practiced in many other ways different from those described herein, and those skilled in the art can make similar modifications without departing from the spirit of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed below.

[0024] It should be noted that when an element is referred to as "fixed to" or "set on" another element, it can be directly on the other element or there may be an intervening element. When an element is considered to be "connected to" another element, it can be directly connected to the other element or there may be an intervening element. The terms "vertical," "horizontal," "left," "right," and similar expressions used herein are for illustrative purposes only and do not represent the only possible implementation. The orientations of the present invention are described in terms of top, bottom, left, and right. Figure 1 The markings in the figure are used as a reference. The X-direction (i.e., along the X-axis), Y-direction (i.e., along the Y-axis), and Z-direction (i.e., along the Z-axis) of this invention are... Figure 1 The annotations in the text serve as the benchmark.

[0025] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0026] First Embodiment

[0027] See Figure 1As shown, this embodiment provides an auxiliary injection device 100 for endothelial reaction testing, used to perform endothelial injections on test animals such as rabbits and mice in animal experiments to conduct endothelial reaction tests. Specifically, the device 100 includes a base assembly 10, which includes a base 11 and an X-axis slide rail 13 disposed on the base; a platform assembly 20, which includes an X-axis slider 21 slidably disposed on the X-axis slide rail 13; a Y-axis slide rail assembly 30, which includes a Y-axis support frame 34 fixed to the base 11, and a Y-axis slide rail 32 disposed in the Y-axis support frame 34; a Z-axis slide rail assembly 40, which includes a Y-axis slider 42, the front surface of which is slidably connected to the Y-axis slide rail 32, and the rear surface of which is provided with a Z-axis slide rail 45; a Z-axis slider assembly 50, which is slidably connected to the Z-axis slide rail 45; and a syringe assembly 60, which is fixedly connected to the Z-axis slider assembly 50. In addition, the auxiliary injection device 100 also has a driving component, which includes an X-axis driving unit XM, a Y-axis driving unit YM, and a Z-axis driving unit ZM, which can drive the X-axis slider 21, the Y-axis slider 42, and the Z-axis slider 51 to move along the X, Y, and Z directions, respectively.

[0028] See also Figure 1As shown, the base assembly 10 includes a base 11, which has a square frame structure. Support legs 12 are provided near the four corners of its lower end face. Optionally, these support legs 12 are telescopic, and their lower end faces are provided with elastic damping elements. By making the support legs 12 telescopic, the levelness of the base 11 can be adjusted by adjusting the height of different support legs 12. The elastic damping elements can reduce vibration and buffer the entire auxiliary injection device. X-axis slide rails 13 are fixedly provided on the left and right sides above the base 11, extending along the X-direction. Additionally, an X-axis drive unit XM is provided on the base 11. The X-axis drive unit XM includes a first screw 15 and a first motor 14 poweredly connected to the first screw 15. Specifically, a first screw 15 is rotatably connected to the base 11. This first screw 15 is located between and parallel to the X-axis slide rails 13 distributed on the left and right sides, while a first motor 14 is located at the front end of the first screw 15. In this embodiment, a coupling connects the output shaft of the first motor 14 to the front end of the first screw 15, allowing the first motor 14 to output power to the first screw 15 to drive its rotation. The upper surface of the X-axis slider 21 has multiple fixing members 212. In this embodiment, there are four fixing members 212, arranged in two rows, distributed near the four corners of the X-axis slider 21. Fixing grooves 212 are provided between the two rows of fixing members 212, extending along the Y direction. During animal experiments, the test animal can be placed in the fixing grooves 212, and its four legs can be bound to each fixing member 212, thus securing the animal during the experiment and facilitating subsequent endothelial reaction tests.

[0029] See Figure 2 As shown, the platform assembly 20 also includes multiple X-axis slide rail connectors 23 fixedly disposed at the lower end of the X-axis slider 21. The multiple slide rail connectors 23 slide in cooperation with the X-axis slide rails 13 located on the left and right sides, thereby achieving a sliding connection of the X-axis slider 21 relative to the base 11 along the X-axis. At least one first nut 22 is also fixedly disposed on the lower end face of the X-axis slider 21. A first screw 15 passes through the first nut 22 and meshes with the first screw 15, thus forming a threaded pair. With the above structural configuration, the first motor 14 drives the first screw 15 to rotate. The rotation of the first screw 15 drives the X-axis slider 21, which is fixedly connected to the first nut 22, to move along the X-axis on the X-axis slide rail 13, thereby driving the X-axis drive unit XM to move the X-axis slider 21 relative to the base 11 along the X-axis.

[0030] See also Figure 1As shown, the Y-axis slider assembly 30 includes a Y-axis support frame 34, which has an overall portal frame structure and extends along the Y-axis and is fixed to the upper surface of the base 11. The Y-axis support frame 34 serves as a support structure to provide support for other components. Y-axis slide rails 32 are fixedly installed in the Y-axis support frame 34. In this embodiment, there are two Y-axis slide rails 32 distributed along the top and bottom. Additionally, a Y-axis drive unit YM is also installed on the Y-axis support frame 34, including a Y-axis screw 33 and a second motor 31 that is poweredly connected to the Y-axis screw 33. Specifically, the Y-axis screw 33 is rotatably connected to the Y-axis support frame 34, located between the two Y-axis slide rails 32, while the second motor 31 is fixedly connected to the Y-axis support frame 34 and located on the left end of the Y-axis screw 33. The output shaft of the second motor 31 is connected to the left end of the Y-axis screw 33 via a coupling to achieve a power connection between the two. Multiple Y-axis slide rail connectors 44 are fixedly connected to the front end face of the Y-axis slider 42. The Y-axis slide rail connectors 44 are slidably connected to the Y-axis slide rail 32, thereby realizing the movement of the Y-axis slider 42 relative to the Y-axis slide rail along the Y direction.

[0031] See Figure 3 As shown, a second nut 46 is fixedly installed on the front end face of the Y-axis slider 42, and the second nut 46 is located between the upper and lower Y-axis slide rails 32. The Y-axis screw 33 passes through the second nut 65 and the two mesh with each other to form a threaded pair. The rotation of the second motor 31 drives the second screw 33 to rotate, and the rotation of the second screw 33 drives the Y-axis slider 42, which is fixedly connected to the second nut 46, to move along the Y-axis on the Y-axis slide rail 32. Therefore, the Y-axis slider 42 can move along the Y-axis relative to the Y-axis slide rail 32 by being driven by the Y-axis drive unit YM.

[0032] See also Figure 1 As shown, the Z-axis slide rail assembly 40 includes a Y-axis slider 42, and a Z-axis slide rail 45 extending along the Z-axis is fixedly disposed on the rear end face of the Y-axis slider 42. In this embodiment, there are two Z-axis slide rails 45, which are disposed on the left and right sides of the Y-axis slider 42. In addition, a Z-axis drive unit ZM is also disposed on the Y-axis slider 42. The Z-axis drive unit ZM includes a Z-axis screw 43 and a third motor 41 that is poweredly connected to the Z-axis screw 43. Specifically, the third screw 43 extends along the Z-axis and is rotatably connected to the rear end face of the Y-axis slider, and is located between the two Z-axis slide rails 45 arranged left and right. The third motor 41 is disposed on the upper end side of the third screw 43 and connected to the third screw 43 to realize power transmission.

[0033] See Figure 4As shown, the Z-axis slider assembly 50 includes a Z-axis slider 51. A Z-axis slide rail connector 54 is provided on the front end face of the Z-axis slider 51. The Z-axis slide rail connector 54 is arranged in two rows on the left and right sides of the Z-axis slider 51 and is slidably connected to the Z-axis slide rail 45, allowing the Z-axis slider 51 to slide along the Z-axis slide rail 45 in the Z-direction. A Z-axis nut 55 is fixedly connected to the rear end face of the Y-axis slider 42, located between the two rows of Z-axis slide rail connectors 54. The upper end of the third screw 43 is powered by the third motor 41, while the lower end passes through and engages with the Z-axis nut 55, thus forming a threaded pair between the third nut 43 and the Z-axis nut 55. The rotation of the third motor 41 drives the third screw 43 to rotate, causing the Z-axis slider 51, fixedly connected to the Z-axis nut 55, to slide along the Z-direction on the Z-axis slide rail 45.

[0034] Therefore, in this embodiment, the X-axis drive unit XM can drive the X-axis slider 21 to move along the X-axis on the X-axis slide rail 13, the Y-axis drive unit YM can drive the Y-axis slider 42 to move along the Y-axis on the Y-axis slide rail 32, and the Z-axis drive unit ZM can drive the Z-axis slider 51 to move along the Z-axis on the Z-axis slide rail 45. Thus, when the syringe assembly 60 is fixedly connected to the Z-axis slider 51 and the experimental animal is fixed to the X-axis slider, the syringe assembly 60 can move relative to the X-axis slider along the X and Y directions to reach the specific injection point. Simultaneously, the syringe assembly 60 can move relative to the X-axis slider along the Z-axis to complete the subsequent injection action.

[0035] See Figure 5 As shown, the syringe assembly 60 includes a syringe housing 61. In this embodiment, the delivery housing 61 is generally L-shaped. A syringe barrel 64 is fixedly disposed in the syringe housing 61, and an injection needle 65 is connected to one end of the syringe barrel 64. A piston (not shown) is disposed in the syringe barrel 64, and the piston is connected to a drive screw 63. A gear nut (not shown) is screwed onto the outer circumference of the drive screw 63. A motor (not shown) is disposed in the delivery housing 61, and the output shaft of the motor is connected to a gear 62. The gear 62 meshes with the gear nut. When the motor drives the gear 62 to rotate, the gear 62 drives the gear nut to rotate, thereby driving the drive screw 63 to move axially, so as to push the piston to slide along the syringe barrel 64 to complete the injection or aspiration action. The Z-axis slider assembly 50 also includes a fixing seat 52, which is fixedly disposed on the rear end face of the Z-axis slider 51. The syringe housing 61 can be embedded in the fixing seat 52 to realize the fixed connection between the delivery assembly 60 and the Z-axis slider 51.

[0036] See also Figure 5As shown, an injection pre-compression component 53 is also fixedly connected to the Z-axis slider 51. The injection pre-compression component 53 includes a connecting rod assembly 53a and a pre-compression ring 53b fixedly connected to the end of the connecting rod assembly 53a. The connecting rod assembly 53a includes a first connecting rod 531 extending along the X-axis (or substantially parallel to the X-axis), a second connecting rod 533 extending along the Z-axis (or substantially parallel to the Y-axis), and a third connecting rod 535 extending along the X-axis (or substantially parallel to the X-axis). The two ends of the second connecting rod 533 are fixedly connected to the first connecting rod 531 and the third connecting rod 535, respectively, thus forming a Z-shaped structure. The end of the first connecting rod 531 furthest from the second connecting rod 533 is fixedly connected to the Z-axis slider 51, thereby achieving a fixed connection between the pre-compression component 53 and the Z-axis slider 51. A pre-compression ring 53b is fixedly connected to the free end of the third connecting rod 535. The central axis of the pre-compression ring 53b is substantially parallel to or coincides with the longitudinal axis of the injection needle 65. The injection needle 65 can pass through the pre-compression ring 534 from top to bottom to insert into the skin of the test animal. In this invention, "substantially parallel" means that the two are parallel or the included angle between them is within ±5 degrees. Alternatively, the longitudinal axis or central axis of the first connecting rod 531, the second connecting rod 533, the third connecting rod 535, and the pre-compression ring 53b can also extend in other directions, as long as the injection needle 65 can pass through the pre-compression ring 53b. For example, see Figure 5 As shown, when the injection needle 65 extends vertically along the Z-axis, the pre-compression ring 53b is horizontally positioned, with its central axis also vertical. At this time, the longitudinal axis of the second connecting rod 533 is also substantially vertical, meaning it is substantially parallel to the central axis of the pre-compression ring 53b. In this embodiment, the tip of the injection needle 64 is positioned above the bottom wall of the pre-compression ring 53b, meaning the height h from the needle tip to the bottom wall of the pre-compression ring 53b is greater than 0. This arrangement ensures that the injection needle 64 does not penetrate the animal's skin when the pre-compression ring 53b first contacts the animal's skin. Furthermore, the second connecting rod 533 includes a first rod unit 5331 and a second rod unit 5332. The first rod unit 5331 is fixed or integrally formed with the first connecting rod 531, and the second rod unit 5332 is fixed or integrally formed with the third connecting rod 535.

[0037] See Figure 6As shown, the end of the first rod unit 5331 is provided with a sliding groove 5331A, and the end of the second rod unit 5332 is slidably inserted into the sliding groove 5331A, thereby making the second connecting rod 533 a telescopic rod. One end of the elastic element 5333 is connected to the end face of the second rod unit 5332, and the other end is connected to the bottom wall of the sliding groove 5331A. The bottom wall and the upper end face of the second rod unit 5332 form their opposite end faces, and the elastic element 5333 is disposed on the opposite end face. The second rod unit 5332 can overcome the elastic force of the spring and slide in the sliding groove 5331A, thereby realizing the extension and retraction of the second connecting rod 533.

[0038] See also Figure 5 As shown, the injection pre-compression component 53 is also provided with a first reinforcing rod 532 and a second reinforcing rod 534. One end of the first reinforcing rod 532 is fixedly connected to the first connecting rod 531, and the other end is fixedly connected to the first rod unit 5331. One end of the second reinforcing rod 534 is fixedly connected to the second rod unit 5332, and the other end is fixedly connected to the third connecting rod 535. The first reinforcing rod 532 is used to enhance the connection strength between the first connecting rod 531 and the first rod unit 5331, and reduce the amount of deformation that occurs at the connection due to force. Similarly, the second reinforcing rod 534 is used to enhance the connection strength between the third connecting rod 535 and the second rod unit 5332, and reduce the amount of deformation that occurs at the connection due to force. By setting the first reinforcing rod 532 and the second reinforcing rod 534, the amount of rotation of the first connecting rod 531 and the third connecting rod 535 around the Y-axis when the injection pre-compression component 53 is subjected to force at the pre-compression ring 534 can be reduced, thereby reducing the amount of deflection of the pre-compression ring 53b during the compression process and preventing uneven compression of the test animal's skin due to the deflection of the pre-compression ring 53b, so as to more evenly compress the skin of the test animal near the injection point.

[0039] The following is combined with Figure 1-5The usage process of the auxiliary injection device 100 for the endothelial reaction test in this embodiment will be described. The test animal is fixed on the X-axis slider 21, and relevant parameters are input into the control system (not shown in the figure), such as the coordinates of the injection start position, the number of injection points, the direction of the injection point arrangement (e.g., along the X-axis or along the Y-axis), and the distance between injection points. The control system automatically calculates the coordinate position of each injection point based on the above input values. The control system controls the drive assembly to drive the X-axis slider 21 and the Y-axis slider 42 to move relative to each other, causing the injection needle 65 to reach the injection start position. The drive assembly drives the Z-axis slider 51 downwards, causing the injection needle 61 and the injection pre-compression member 53 to gradually approach the test animal's skin until the bottom wall of the pre-compression ring 53b makes initial contact with the test animal's skin. Since the needle tip is above the bottom wall of the pre-compression ring 53b and the distance between them is h, the height of the needle tip above the animal's skin is also h when the bottom wall of the pre-compression ring 53b makes initial contact with the test animal's skin. As the Z-axis slider 51 continues to move downwards, the pre-compression ring 53b squeezes the animal's skin. The reaction force of this compression causes the second connecting rod unit 5332 to overcome the elastic force of the elastic element 5333 and slide upwards relative to the first rod unit 5331, thereby causing the second connecting rod 533 to contract. When the contraction amount of the second connecting rod 533 is h, it indicates that the needle tip has moved downwards a distance h relative to the pre-compression ring 53b. At this point, the needle tip first contacts and begins to penetrate the test animal's skin. When the Z-axis slider 51 continues to move downwards by ΔH, the depth to which the injection needle 61 penetrates the test animal's skin is also ΔH. When ΔH reaches a predetermined value, the needle tip remains stationary at this position, and the controller controls the motor in the syringe assembly 60 to rotate, pushing the piston to achieve quantitative injection. After injection, the controller controls the Z-axis slider 51 to move upwards, causing the needle tip to withdraw from the test animal's body. Then, the controller controls the injection needle 61 to reach the next injection coordinate position, repeating the above injection process to complete the injection at the next injection point. In this embodiment, by setting the injection pre-compression component 53, the skin around the injection point is squeezed before the injection needle 61 is inserted into the skin of the test animal. This makes the skin around the injection point smoother and tighter, which facilitates subsequent injection operations, improves the success rate of injection, and prevents injection failure due to uneven or too loose skin at the injection point.

[0040] In other embodiments, a pressure sensor can be provided on the lower end face of the pre-compression ring 53b to measure the movement distance of the first lever unit 5331 relative to the second lever unit 5332. Assume the reaction force exerted by the skin on the pre-compression ring is F, the stiffness of the elastic element 5333 is K, and it is in its uncompressed natural state initially. When the force F detected by the pressure sensor is K*(H+ΔH), it indicates that the movement distance of the first lever unit 5331 relative to the second lever unit 5332 is H+ΔH, meaning the injection needle 61 has penetrated the skin of the experimental animal to a depth of ΔH. At this point, the control unit can stop driving the Z-axis slider 51, thereby completing the control of the injection needle 61 penetrating the skin of the experimental animal to a predetermined depth.

[0041] In other embodiments, a disinfection element can be provided on the lower end face of the pre-compression ring 53b. This disinfection element can be medical cotton soaked in alcohol, iodine, or other disinfectants. Since the pre-compression ring 53b contacts the animal's skin before the injection needle 61, the pre-compression ring 53b with the disinfection element can be made to reciprocate in a circular or linear motion near the injection point before injection, thereby disinfecting the injection point area and reducing the possibility of infection at the injection point in the experimental animal.

[0042] In other embodiments, a camera can be installed on the lower end face of the third connecting rod 535 or the pre-compression ring 53b. Before the experiment begins, the operator marks the initial injection point. After the camera takes a picture of the experimental animal, it transmits the image to the control system. The control system recognizes the image based on the captured image (using methods such as convolutional neural networks and deep neural networks) and calculates the coordinates of the marked point. This allows the auxiliary injection device 100 to automatically align the initial injection point of the injection needle 65 according to the manually marked point, eliminating the need for manual initial injection point alignment.

[0043] See Figure 7The connection method between the syringe assembly 60 and the fixing base 52 is described below. The fixing base 52 is provided with a fixing groove 521, one end of which has a bottom wall 5211, and the other end extends to the upper end face of the fixing base 52 to form a through groove. At least one side wall of the fixing groove 521 is provided with a limiting groove 522, which is arranged parallel to the fixing groove 521. The housing 61 of the syringe assembly 60 is provided with a limiting protrusion 611 that mates with the limiting groove 522. The limiting protrusion 611 is made of an elastic body and is interference-fitted with the limiting groove 522. When the syringe assembly 60 needs to be installed into the fixing base 52, after aligning the limiting protrusion 611 with the limiting groove 522, the housing 61 is slid down along the fixing groove 521 from top to bottom until the bottom 612 of the housing 61 abuts against the bottom wall 5211 of the fixing groove 521. Because the limiting protrusion 611 and the limiting groove 522 are interference-fitted, the injection assembly 60 and the fixing seat 52 can be fixedly connected. When it is necessary to disassemble the injection assembly 60, it is only necessary to overcome the frictional resistance between the limiting protrusion 611 and the limiting groove 522 and slide the injection assembly 60 upward to separate it from the fixing seat 52.

[0044] The embodiments described above are merely examples of several implementations of the present invention, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the invention patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these all fall within the scope of protection of the present invention. The scope of protection of this patent should be determined by the appended claims.

Claims

1. An auxiliary injection device for endothelial reaction testing, characterized in that, include: A base assembly (10) includes a base (11) and an X-axis slide rail (13) disposed on the upper side of the base (11); an X-axis slider (21) slidably connected to the X-axis slide rail (13); a Y-axis slide rail assembly (30) includes a Y-axis support frame (34) fixedly connected to the base, and a Y-axis slide rail (32) disposed on the Y-axis support frame (34); and a Z-axis slide rail assembly (40) includes a Y-axis slider (4). 2) and a Z-axis slide rail (45) disposed on the rear end face of the Y-axis slider, wherein the Y-axis slider (42) is slidably connected to the Y-axis slide rail (32); a Z-axis slider (51) is slidably connected to the Z-axis slide rail (45); a syringe assembly (60) is fixedly connected to the Z-axis slider (51); and a drive assembly is capable of driving the X-axis slider (21), the Y-axis slider (42) and the Z-axis slider (51) to move along the X-axis, Y-axis and Z-axis respectively. It also includes an injection pre-compression component (53). The syringe assembly (60) includes an injection needle (65). The injection pre-compression component (53) includes a telescopic connecting rod assembly (53a) and a pre-compression ring (53b). One end of the connecting rod assembly (53a) is fixedly connected to the Z-axis slider (51), and the other end is fixedly connected to the pre-compression ring (53b). The injection needle (65) can pass through the pre-compression ring (53b).

2. The auxiliary injection device for endothelial reaction testing according to claim 1, characterized in that, The longitudinal axis of the injection needle (65) is substantially parallel to or coincides with the central axis of the pre-compression ring (53b).

3. The auxiliary injection device for endothelial reaction testing according to claim 1, characterized in that, A pressure sensor is provided on the lower end face of the preload ring (53b).

4. The auxiliary injection device for endothelial reaction testing according to claim 1, characterized in that, The lower end face of the pre-compression ring (53b) is provided with a sterilization component.

5. The auxiliary injection device for endothelial reaction testing according to claim 1, characterized in that, The connecting rod assembly (53a) includes a first connecting rod (531), a second connecting rod (533), and a third connecting rod (535) connected in sequence. The free end of the first connecting rod (531) is fixedly connected to the Z-axis slider (51), and the third connecting rod (535) is fixedly connected to the preload ring (53b).

6. The auxiliary injection device for endothelial reaction testing according to claim 5, characterized in that, The second connecting rod (533) includes a first rod unit (5331) and a second rod unit (5332) that are slidably connected to each other, and an elastic element (5333) is also provided between the opposite end faces of the first rod unit (5331) and the second rod unit (5332).

7. An auxiliary injection device for endothelial reaction testing according to claim 6, characterized in that, It also includes a first reinforcing rod (532) and a second reinforcing rod (534). One end of the first reinforcing rod (532) is connected to the first connecting rod (531), and the other end is connected to the first rod unit (5331). One end of the second reinforcing rod (534) is connected to the third connecting rod (535), and the other end is connected to the second rod unit (5332).

8. An auxiliary injection device for endothelial reaction testing according to claim 5, characterized in that, The longitudinal axis of the second connecting rod (533) is substantially parallel to the central axis of the preload ring (53b).

9. An auxiliary injection device for endothelial reaction testing according to claim 1, characterized in that, A camera is also provided on the injection pre-compression component (53).

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