Ointment for treating rhagadia manus and pedis and preparation method thereof

Abstract

The invention discloses an ointment for preventing and treating rhagadia manus and pedis and a preparation method thereof. The ointment is prepared from the following components: purified water, vaseline, glycerol, glycerin monostearate, xanthan gum, carbomer, methylparaben and 8-hydroxyquinoline sulfate. The ointment can effectively improve skin cracks, swelling and bleeding in a rat chapping model constructed by a NaOH solution. The traditional Chinese medicine composition has the effects of moisturizing and protecting skin, promoting hand and foot crack healing and the like, has unique remarkable advantages in the aspect of treating hand and foot rhagadia, and is suitable for large-area popularization and application.

Description

Technical Field

[0001] The invention relates to the field of ointments, and in particular to an ointment for preventing and treating chapped hands and feet and a preparation method thereof. Background Art

[0002] Chapped hands and feet refer to dry skin and cracks on the hands and feet caused by various reasons, often accompanied by pain. It is a common skin disease of the hands and feet. The stratum corneum of the normal human palm and sole skin is thick and has no sebaceous glands. It lacks sebum protection. Under external stimulation, the stratum corneum will become brittle and hard. Once the traction and pressure exceed the normal tolerance limit of the skin, it will crack and cause disease. Common inducing factors include dryness, friction, trauma, acid and alkali substances, organic solvents (soap detergent), etc. Chapped hands and feet need to be differentiated from hand and foot eczema, palmoplantar keratosis, tinea pedis and ichthyosis. It may also be combined with tinea pedis, eczema, ichthyosis, etc.

[0003] Chapped hands and feet not only cause pain and discomfort, but also make the appearance rough and ugly, affecting the appearance. Due to the cracked skin, it is easy to collect dust and bacteria, which provides opportunities for infection, resulting in skin redness, swelling, suppuration, itching, pain, etc. It will limit the movement ability of the hands and feet, affecting exercise and daily life. Patients with chapped hands and feet generally feel insecure about their hands and feet, which affects their mental health.

[0004] Simple chapped hands and feet can be treated with external application of vitamin E cream or oral vitamin B6 according to doctor's advice to improve symptoms. For patients with other diseases combined with eczema and ichthyosis, it is recommended that they actively treat the primary disease, and glucocorticoid preparations such as hydrocortisone cream or oral vitamin A can be used under the guidance of a doctor. For patients with diseases such as eczema and ichthyosis, it is necessary to treat the primary disease. Glucocorticoid preparations such as hydrocortisone cream can reduce inflammation and itching and promote skin repair. Vitamin A can regulate the keratinization process of the skin and improve the dryness and roughness of the skin. However, the clinical efficacy of the medicaments for chapped hands and feet is not satisfactory, or long-term use has an irritating effect, so inventing an ointment for treating chapped hands and feet is the purpose of the present invention. Summary of the invention

[0005] In view of the problems that the ointment for treating chapped hands and feet in the prior art has poor efficacy and irritation, the present invention provides an ointment for preventing and treating chapped hands and feet and a preparation method thereof.

[0006] In order to achieve the above object, the present invention specifically adopts the following technical solutions: A medicinal ointment for preventing and treating chapped hands and feet (denoted as ZZ001) is composed of the following components by weight: 70-90% purified water, 1-10% vaseline, 1-10% glycerol, 1-10% glyceryl monostearate, 0.1-1% xanthan gum, 0.1-1% carbomer, 0.1-1% methylparaben, and 0.1-1% 8-hydroxyquinoline sulfate.

[0007] The preparation process of the chapped skin ointment (ZZ001) is as follows: (1) Weigh vaseline, glyceryl monostearate, and glycerin in proportion, put them into a container, heat to 80-85° C., and stir until completely dissolved to form the oil phase; (2) Weigh water, xanthan gum, carbomer, methylparaben, and 8-hydroxyquinoline sulfate in proportion, put them into a container, heat to 80-85° C., and stir until completely dissolved to form the aqueous phase; (3) Add the oil phase from step (1) to the water phase from step (2) under stirring and stir evenly; then cool to room temperature.

[0008] Preferably, in step (3), the oil phase of step (1) is first added to the water phase of step (2) at a stirring speed of 20 to 100 r / min, and then stirred evenly at a stirring speed of 5000 to 10000 r / min (for 1 to 10 minutes).

[0009] The ointment for preventing and treating chapped hands and feet is used as a medicine for preventing and treating chapped hands and feet.

[0010] The effect of ZZ001 was observed in an animal model of chapped hands and feet, and it was found that it can alleviate the clinical symptoms of chapped hands and feet.

[0011] The animal model of chapped hands and feet is to apply NaOH solution. This model was used to observe the therapeutic effect of ZZ001 on chapped hands and feet. The results showed that ZZ001 effectively improved the skin cracks caused by the application of NaOH solution and induced wound healing. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Figure 1 This is a gross morphological observation of the therapeutic effect of ZZ001 on the chapped rat model; Figure 2 To provide the scoring and statistical analysis of skin damage in rat models induced by ZZ001; Figure 3 The effect of HYP (hydroxyproline) on skin in the ZZ001 rat model; Figure 2 , Figure 3 In the table, *, **, *** and **** indicate p<0.05, p<0.01, p<0.001 and p<0.0001, respectively. DETAILED DESCRIPTION

[0013] In order to make the technical purpose, technical scheme and beneficial effects of the present invention clearer, the technical scheme of the present invention is further explained below in conjunction with specific embodiments. However, the implementation is intended to explain the present invention and cannot be understood as limiting the present invention. If no specific technology or conditions are specified in the embodiments, the technology or conditions described in the literature in the field or the product manual shall be followed.

[0014] Example 1: An ointment for preventing and treating chapped hands and feet (denoted as ZZ001) and its preparation process In terms of mass percentage, the formula of ZZ001 is as follows: 88.2% purified water, 2% vaseline, 3% glycerin, 6% glyceryl monostearate, 0.2% xanthan gum, 0.1% carbomer, 0.2% methylparaben, and 0.3% 8-hydroxyquinoline sulfate.

[0015] The preparation process of the ointment for treating chapped skin is as follows: (1) Weigh vaseline, glyceryl monostearate, and glycerin in proportion, put them into a container, heat to 80-85° C., and stir until completely dissolved to form the oil phase; (2) water, xanthan gum, carbomer, methylparaben, and 8-hydroxyquinoline sulfate are placed in a suitable container, heated to 80-85°C, and stirred until completely dissolved to serve as the aqueous phase; (3) Start stirring at a speed of 20 r / min, slowly add the oil phase at 80-85° C. in step (1) to the water phase at 80-85° C. in step (2), adjust the stirring speed to 40 r / min, stir for 20 s-1 min, start the homogenizer, and homogenize at 8000 r / min for 3 min; Cool to room temperature.

[0016] Example 2: An ointment for preventing and treating chapped hands and feet (denoted as ZZ001) and its preparation process In terms of mass percentage, the formula of ZZ001 is as follows: 70% purified water, 10% vaseline, 10% glycerin, 6% glyceryl monostearate, 1% xanthan gum, 1% carbomer, 1% methylparaben, and 1% 8-hydroxyquinoline sulfate.

[0017] The preparation process of the ointment for treating chapped skin is as follows: (1) Weigh vaseline, glyceryl monostearate, and glycerin in proportion, put them into a container, heat to 80-85° C., and stir until completely dissolved to form the oil phase; (2) water, xanthan gum, carbomer, methylparaben, and 8-hydroxyquinoline sulfate are placed in a suitable container, heated to 80-85°C, and stirred until completely dissolved to serve as the aqueous phase; (3) Start stirring at a speed of 20 r / min, slowly add the oil phase at 80-85° C. in step (1) to the water phase at 80-85° C. in step (2), adjust the stirring speed to 40 r / min, stir for 20 s-1 min, start the homogenizer, and homogenize at 8000 r / min for 5 min; Cool to room temperature.

[0018] Example 3: An ointment for preventing and treating chapped hands and feet (denoted as ZZ001) and its preparation process In terms of mass percentage, the formula of ZZ001 is as follows: 90% purified water, 1% vaseline, 1% glycerin, 7.6% glyceryl monostearate, 0.1% xanthan gum, 0.1% carbomer, 0.1% methylparaben, and 0.1% 8-hydroxyquinoline sulfate.

[0019] The preparation process of the ointment for treating chapped skin is as follows: (1) Weigh vaseline, glyceryl monostearate, and glycerin in proportion, put them into a container, heat to 80-85° C., and stir until completely dissolved to form the oil phase; (2) water, xanthan gum, carbomer, methylparaben, and 8-hydroxyquinoline sulfate are placed in a suitable container, heated to 80-85°C, and stirred until completely dissolved to serve as the aqueous phase; (3) Start stirring at a speed of 20 r / min, slowly add the oil phase at 80-85° C. in step (1) to the water phase at 80-85° C. in step (2), adjust the stirring speed to 40 r / min, stir for 20 s-1 min, start the homogenizer, and homogenize at 8000 r / min for 2 min; Cool to room temperature.

[0020] Application Example 1: Gross morphological observation of the therapeutic effect of ZZ001 on chapped rat model The experimental animals were 6-week-old female SD rats purchased from Sibefor (Beijing) Biotechnology Co., Ltd. After the rats adapted for 1 week, 5 rats were kept as the blank group, and the rest of the rats were used as the model group for modeling. All rats were anesthetized with chloral hydrate and then depilatory cream was used to remove the hair on the back, with a depilatory area of ​​about 3*3cm. After the depilation, the modeling rats were smeared with 0.5M NaOH solution on the back skin, about 1mL each time. This operation was performed once a day. After 5-7 days, the cracking, swelling and scab formation of the rat's back skin were used as signs of successful modeling. The blank group rats only removed the hair without any treatment.

[0021] After the modeling was successful, the rats were randomly divided into 3 groups, 5 in each group. They were the model group, the ZZ001 group (prepared in Example 1) and the positive drug group, and the positive drug was commercially available Mayinglong urea ointment. The ZZ001 group and the urea ointment group were applied twice a day, 0.3 g each time, and the model group was applied with normal saline every day, 1 mL each time.

[0022] The results are as follows Figure 1 As shown, compared with the blank control group, the model group showed typical chapped skin characteristics, such as skin cracks, bleeding, swelling, tissue fluid exudation, scabs, etc., while the drug-treated group and the positive drug group both showed that they could significantly alleviate these skin injuries, showing only individual bleeding spots and scabs.

[0023] Application Example 2: Scoring and statistical analysis of skin damage in rat models with ZZ001 The skin lesion repair was visually evaluated every day and the data was recorded. The skin lesion scoring criteria were as follows: 0 point: the skin lesion disappeared completely; 1 point: the skin lesion repaired area reached 1 / 2 to 1; 2 points: the skin lesion repaired area reached 1 / 4 to 1 / 2; 3 points: the skin lesion repaired area reached 0 to 1 / 4.

[0024] The results are as follows Figure 2 As shown, the model group showed higher skin damage, larger lesion area, and extremely poor self-recovery ability, while the ZZ001 group and the positive drug group could greatly alleviate NaOH-induced skin damage.

[0025] Application Example 3: Effect of ZZ001 on the content of hydroxyproline (HYP) in the skin of rats with chapped skin After the experiment, skin samples from the back of the rats were collected. 50 mg of skin from the application site was cut from each rat in each group, and the hydroxyproline (HYP) content in the back skin of the rats was determined using the hydroxyproline (HYP) assay kit (alkaline hydrolysis method) of Nanjing Jiancheng Biotechnology Co., Ltd. Figure 3 The results showed that compared with the normal (blank control) group of mice, under the continuous stimulation of NaOH solution, the HYP of the skin of the model control group rats decreased significantly, the skin surface was seriously damaged, and the skin healing ability and healing speed decreased significantly, while the HYP of the drug group and the positive control group increased significantly, close to the content of the blank group, indicating that under the treatment of ZZ001 and positive drugs, the skin healing speed increased and was close to normal skin at the end of the experiment. The HYP content of ZZ001 was higher than that of the positive drug urea ointment, indicating that the effect of ZZ001 was better than that of the positive control.

[0026] The above results show that ZZ001 can relieve the clinical symptoms of chapped hands and feet, improve skin cracks, and induce wound healing. It shows good application prospects in the treatment of chapped hands and feet.

Claims

1. An ointment for preventing and treating chapped hands and feet, characterized in that: The composition is as follows in parts by weight: 70-90% purified water, 1-10% vaseline, 1-10% glycerin, 1-10% glyceryl monostearate, 0.1-1% xanthan gum, 0.1-1% carbomer, 0.1-1% methylparaben, and 0.1-1% 8-hydroxyquinoline sulfate.

2. The method for preparing the ointment for preventing and treating chapped hands and feet according to claim 1, characterized in that: The process is as follows: (1) Weigh vaseline, glyceryl monostearate, and glycerin in proportion, put them into a container, heat to 80-85° C., and stir until completely dissolved to form the oil phase; (2) Weigh water, xanthan gum, carbomer, methylparaben, and 8-hydroxyquinoline sulfate in proportion, put them into a container, heat to 80-85° C., and stir until completely dissolved to form the aqueous phase; (3) Add the oil phase from step (1) to the water phase from step (2) while stirring, and stir evenly; then cool to room temperature.

3. The method for preparing the ointment for preventing and treating chapped hands and feet according to claim 1, characterized in that: In step (3), the oil phase of step (1) is first added to the water phase of step (2) at a stirring speed of 20 to 100 r / min, and then stirred evenly at a stirring speed of 5000 to 10000 r / min.

4. Use of the ointment for preventing and treating chapped hands and feet according to claim 1 as a medicine for preventing and treating chapped hands and feet.

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