Traditional Chinese medicine composition for preventing and treating cerebral infarction as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating cerebral infarction and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine, the traditional Chinese medicine composition is prepared from herba epimedii, radix clematidis, hairyvein agrimony, pseudo-ginseng, leech, astragalus membranaceus, Chinese yam, pulp of dogwood fruit, fried malt, safflower, rheum officinale, raw hawthorn, liquorice, acorus calamus and rosemary. Different from the traditional therapy, the traditional Chinese medicine dialectical thinking is utilized, the comprehensive thought of eliminating phlegm and blood stasis, dredging meridians and collaterals to treat symptoms, strengthening body resistance to eliminate pathogenic factors, restoring consciousness and promoting intelligence, tonifying spleen and kidney and consolidating basis to treat root causes is provided, and the root-treating, infarction-preventing and encephalatrophy-preventing effects of tonifying spleen and kidney, nourishing qi and blood and restoring consciousness are more emphasized while blood stasis is removed and thrombolysis is performed. The traditional Chinese medicine composition has the advantages that the medicines are used together, the compatibility is proper, the effects of strengthening the body resistance to eliminate pathogenic factors, invigorating the spleen, replenishing qi, dissolving turbidity, restoring consciousness, dispersing blood stasis and dredging collaterals are achieved together, the ideal effects of relieving cerebral infarction symptoms, preventing cerebral infarction relapse, preventing and treating middle-aged and elderly cerebral infarction, dementia and the like are achieved, the curative effect is remarkable, the traditional Chinese medicine composition is obviously superior to common western medicine therapy, and the traditional Chinese medicine composition is worthy of clinical popularization and application.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine, relates to a traditional Chinese medicine composition for preventing and treating cerebral infarction, and also relates to a preparation method and application of the traditional Chinese medicine composition for preventing and treating cerebral infarction. Background Art

[0003] Cerebral infarction, formerly known as cerebral infarction, also known as ischemic stroke, refers to ischemic necrosis or softening of localized brain tissue caused by impaired blood supply to the brain, ischemia, and hypoxia. Common clinical types of cerebral infarction include cerebral thrombosis, lacunar infarction, and cerebral embolism, and cerebral infarction accounts for 80% of all strokes. Diseases closely related to it include: diabetes, obesity, hypertension, rheumatic heart disease, arrhythmia, dehydration due to various reasons, various arteritis, shock, and excessive and rapid drop in blood pressure. The main clinical manifestations are sudden fainting, unconsciousness, hemiplegia, speech disorders, and intellectual disabilities. Cerebral infarction not only poses a great threat to human health and life, but also brings great pain and heavy burdens to patients, families, and society.

[0004] At present, in clinical medicine, most hospitals treat cerebral infarction by infusion, promoting blood circulation and nourishing nerves, or promoting blood circulation and removing blood stasis to clear blood clots, which excessively pursues symptomatic treatment and weakens the root cause of the patient's illness. In view of this, a Chinese medicine composition for preventing and treating cerebral infarction and a preparation method thereof are specially proposed. Summary of the invention

[0005] The purpose of the present invention is to provide a Chinese medicine composition for preventing and treating cerebral infarction and a preparation method thereof, which has a good effect on the prevention and treatment of cerebral infarction.

[0006] The first technical scheme adopted by the present invention is a traditional Chinese medicine composition for preventing and treating cerebral infarction, which is prepared from the following medicinal materials: Herba Epimedii, Radix Clematis, Herba Agrimoniae, Radix Notoginseng, Hirudo, Radix Astragali, Rhizoma Dioscoreae, Fructus Corni, Roasted Malt, Safflower, Rhubarb, Raw Hawthorn, Licorice, Acorus Calamus, and Rosemary.

[0007] Furthermore, the Chinese medicine composition is made of the following raw materials in parts by weight: 15-30 parts of Epimedium, 10-20 parts of Clematis, 15-30 parts of Agrimoniae, 10-20 parts of Panax notoginseng, 5-10 parts of Leech, 15-30 parts of Astragalus, 15-30 parts of Dioscorea, 10-20 parts of Cornus, 10-15 parts of roasted malt, 6-10 parts of Carthamus, 6-10 parts of Rhubarb, 10-20 parts of Hawthorn, 5-10 parts of Licorice, 10-15 parts of Calamus, and 2-3 parts of Rosemary.

[0008] Furthermore, the Chinese medicine composition is made of the following raw materials in parts by weight: 25 parts of Epimedium, 15 parts of Clematis, 25 parts of Agrimoniae, 15 parts of Panax notoginseng, 8 parts of Leech, 23 parts of Astragalus, 22 parts of Dioscorea, 15 parts of Cornus, 12 parts of roasted malt, 8 parts of Safflower, 8 parts of Rhubarb, 15 parts of Hawthorn, 7 parts of Licorice, 12 parts of Calamus, and 3 parts of Rosemary.

[0009] The second technical solution adopted by the present invention is a method for preparing a Chinese medicine composition for preventing and treating cerebral infarction, which is specifically implemented according to the following steps:

[0010] S1: Material selection and proportioning: proportion and mix the medicinal materials according to the above weight proportions;

[0011] S2: Cleaning and drying: remove dust and impurities from the surface of the medicinal materials and dry them in the sun for 1-2 days;

[0012] S3: Drying: Drying at a temperature range of 40-60°C until the moisture content of the medicinal materials drops below 10%;

[0013] S4: Crushing and grinding: crushing the medicinal materials by a crusher;

[0014] S5: sieving: filtering with a 120-mesh sieve to obtain drug powder;

[0015] S6: Packaging.

[0016] Furthermore, the daily drying time in S2 is not less than 6 hours.

[0017] Furthermore, the drying time in S3 is 12-24 hours.

[0018] Furthermore, in S3, a hot air circulation oven or an infrared dryer is used for drying.

[0019] Furthermore, in S4, the material is crushed and ground by a hammer mill or a ball mill.

[0020] Furthermore, in S5, filtering is performed through a circular vibrating screen or a linear vibrating screen.

[0021] The third technical solution adopted by the present invention is the application of a traditional Chinese medicine composition for preventing and treating cerebral infarction. Take 4-6g of the traditional Chinese medicine composition, mix it into a paste with warm water, and take it warm within 30 minutes after a meal; 1-3 times a day, four weeks as a course of treatment, which can prevent and treat cerebral infarction.

[0022] The Chinese medicine composition of the present invention is different from traditional therapies. It uses the dialectical thinking of traditional Chinese medicine and puts forward a comprehensive idea of ​​"removing phlegm and blood stasis, unblocking meridians to treat symptoms; strengthening the body and eliminating evil, refreshing the brain and improving intelligence, strengthening the spleen and kidney, and consolidating the root to treat the root". While removing blood stasis and dissolving thrombus, it pays more attention to strengthening the spleen and kidney, nourishing qi and blood, refreshing the brain and preventing infarction and brain atrophy. All the medicines are used together and properly matched to play the effects of strengthening the body and eliminating evil, strengthening the spleen and replenishing qi, removing turbidity and refreshing the brain, removing blood stasis and unblocking meridians. It has an ideal effect on the relief of various symptoms of cerebral infarction and the prevention of the recurrence of cerebral infarction, as well as the prevention and treatment of cerebral infarction and dementia in the middle-aged and elderly. The curative effect is remarkable and significantly better than the commonly used Western medicine therapy. It highlights the characteristics of "effective, proven, and cheap" and "treating both the symptoms and the root" of traditional Chinese medicine treatment, and is worthy of clinical promotion and application. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 The invention is a schematic flow chart of a method for preparing a Chinese medicine composition for preventing and treating cerebral infarction. DETAILED DESCRIPTION

[0024] The present invention is described in detail below in conjunction with the accompanying drawings and specific embodiments. In the present invention, unless otherwise specified, all equipment and raw materials can be purchased from the market or are commonly used in the industry.

[0025] Cerebral infarction belongs to the category of stroke in traditional Chinese medicine. According to the severity of the disease and the depth of the disease, stroke follows the classification method of "Golden Chamber Synopsis" and is diagnosed as middle meridians and middle viscera. There is generally no change in consciousness during the onset of cerebral infarction, which is manifested as sudden occurrence of facial paralysis, speech impairment, hemiplegia, etc. without fainting, which belongs to the middle meridians of stroke. According to the syndrome differentiation method of meridians in stroke in the "Guidelines for Clinical Research of New Chinese Medicines" formulated and issued by the Ministry of Health in 1993, Chinese medicine syndrome differentiation is divided into five types: liver yang hyperactivity, wind and fire disturbance syndrome; wind phlegm and blood stasis, obstruction of meridians syndrome; phlegm heat and viscera, wind and phlegm disturbance syndrome; qi deficiency and blood stasis syndrome; yin deficiency and wind movement syndrome. In current clinical medicine, most hospitals treat cerebral infarction by infusion, blood circulation and nerve nutrition, or blood circulation and blood stasis to clear blood clots, excessive pursuit of symptomatic dredging, and weakening the root cause of the patient's illness.

[0026] In clinical practice, it is found that most patients with cerebral infarction are suffering from underlying deficiency and superficial excess. The underlying deficiency is qi deficiency, yang deficiency or blood deficiency, yin deficiency, while the superficial excess is mostly phlegm dampness and blood stasis. After years of clinical practice, it is proposed to strengthen the body and eliminate evil, wake up the brain and improve intelligence, strengthen the spleen and kidney, consolidate the body to treat the root cause, and eliminate phlegm and blood stasis, and dredge the meridians to treat the symptoms, so as to achieve the effect of treating both the symptoms and the root cause. Figure 1 As shown, a Chinese medicine composition for preventing and treating cerebral infarction of the present invention is prepared by the following process, which is as follows:

[0027] S1. Material selection and proportion

[0028] According to traditional Chinese medicine theory, select Chinese medicine with the effects of promoting blood circulation and removing blood stasis, replenishing qi and nourishing blood, clearing away heat and detoxifying, etc. Specifically include: Epimedium, Clematis, Agrimonia, Panax notoginseng, leech, Astragalus, Chinese yam, Cornus officinalis, fried malt, safflower, rhubarb, raw hawthorn, licorice, calamus, rosemary.

[0029] Ratio basis:

[0030] Main medicine: Epimedium, Clematis, and Agrimonia, which have the effects of nourishing kidney yang, strengthening tendons and bones, removing rheumatism, astringing and stopping bleeding, strengthening the body, and replenishing deficiency.

[0031] Assistant medicines: Astragalus, yam, and cornus fruit can nourish the spleen and kidneys and greatly replenish vital energy; Panax notoginseng, leech, hawthorn, safflower, and rhubarb can remove blood stasis and dredge meridians, which can not only remove blood stasis and eliminate spots, but also do not harm the body.

[0032] Auxiliary drugs: Polygala tenuifolia, Acorus calamus, Poria cocos, and fried malt, which can strengthen the spleen, eliminate turbidity, calm the mind and improve intelligence.

[0033] Assistant drugs: Rosemary and Licorice, which can clear the mind and harmonize various drugs.

[0034] The Chinese medicine composition is prepared according to the following weight parts: 15-30 parts of Epimedium, 10-20 parts of Clematis, 15-30 parts of Agrimoniae, 10-20 parts of Panax notoginseng, 5-10 parts of Leech, 15-30 parts of Astragalus, 15-30 parts of Chinese yam, 10-20 parts of Cornus, 10-15 parts of roasted malt, 6-10 parts of safflower, 6-10 parts of rhubarb, 10-20 parts of raw hawthorn, 5-10 parts of liquorice, 10-15 parts of calamus and 2-3 parts of rosemary.

[0035] The prescription of traditional Chinese medicine pays attention to "monarch, minister, assistant and messenger". The "monarch medicine" of the present invention is "three immortals": Xianlingpi has a warm nature, is pungent and sweet, is non-toxic, can nourish kidney yang, strengthen tendons and bones, and eliminate rheumatism, and has good effects on soreness of waist and knees, asthma and cough due to kidney deficiency, cold infertility, rheumatic pain, hemiplegia, etc. Xianhecao is astringent and hemostatic. Modern research has shown that Xianhecao contains agrimony, tannins and a small amount of vitamin K, which has a good hemostatic effect. "Modern Practical Chinese Medicine" lists it as a tonic astringent hemostatic agent. Xianhecao can also strengthen the body and replenish the deficiency. It has a good effect on fatigue, fatigue, sallow complexion, spontaneous sweating due to qi deficiency, palpitations, etc., so it is called debility grass. Qi is the leader of blood, and qi can regulate blood, so it can effectively prevent the occurrence of cerebral hemorrhage and cerebral infarction. Clematis chinensis has the effects of removing rheumatism, dredge meridians and relieve pain, and treat bone stagnation. It is used to treat rheumatic pain, limb numbness, tendon spasm, flexion and extension difficulties, throat stagnation and other symptoms. Modern pharmacological research has shown that Clematis chinensis has analgesic, choleretic, anti-histamine excitation and diuretic effects. Clematis chinensis can also stimulate macrophages, regulate self-immunity, improve body resistance, and lower blood pressure. These three medicines are the main medicines, which can play a good effect on limb numbness, meridian stagnation, hemiplegia, kidney deficiency and weak tendons, and leg and foot stagnation caused by cerebral infarction.

[0036] Astragalus, Chinese yam, and cornus officinalis are used as "minister medicines" to nourish the spleen and kidneys, replenish vital energy, and cooperate with the main medicine to strengthen the spleen and kidneys, nourish qi and blood, benefit the brain marrow, and consolidate the root cause; many patients experience brain atrophy after cerebral infarction, mainly because the brain marrow is not nourished after the blood supply is insufficient due to the obstruction. Panax notoginseng, leech, hawthorn, safflower, and rhubarb are used as "minister medicines" to dissipate blood stasis and dredge the meridians, which can not only dissipate blood stasis and eliminate spots, but also not hurt the body. The "general" rhubarb is used in the prescription to dissipate blood stasis and remove the old, and to support the old and bring forth the new. The use of leeches focuses on its anti-coagulation, anti-thrombosis, and protection of brain nerves. It has been recorded in the "Shennong Bencao Jing". In recent years, it has been newly discovered that leeches have special effects in preventing and treating cardiovascular and cerebrovascular diseases and anti-cancer. "Adjuvant medicines" use Polygala, Acorus calamus, Poria, fried malt, etc. to strengthen the spleen and dissipate turbidity, and can calm the mind, improve intelligence, and clear the mind. Rosemary is mainly used as the “enhancer drug” in order to use the fragrance to reach the clear orifices and attract the spirit. Licorice harmonizes the various drugs, which is nourishing but not dry, and dispersing but tangible.

[0037] S2. Washing and drying

[0038] Select the raw materials of various medicinal materials that are free of insects, mildew, and impurities, wash them with clean water, and remove the dust and impurities on the surface. After washing, spread the medicinal materials evenly in the sun to dry until the surface of the medicinal materials is dry without water droplets, but avoid excessive exposure to the sun to cause the loss of effective ingredients of the medicinal materials.

[0039] Environment selection: Choose a sunny and well-ventilated place for drying. The ideal place can be an outdoor drying yard or a special drying shed.

[0040] Time: The drying time is 1-2 days, and the drying time is not less than 6 hours per day. The specific time can be adjusted according to the weather conditions and the dryness of the medicinal materials.

[0041] When drying, avoid rain and dust pollution. Cover the herbs with gauze. Turn the herbs regularly to ensure even drying. Avoid direct sunlight to prevent the active ingredients in the herbs from being destroyed.

[0042] S3. Drying

[0043] Put the dried medicinal materials into the dryer and set the appropriate temperature and time to ensure that the moisture inside the medicinal materials is completely evaporated while keeping the effective ingredients of the medicinal materials intact.

[0044] Equipment selection: Use low-temperature drying equipment, such as a hot air circulation oven or an infrared dryer.

[0045] Temperature control: The temperature is controlled at 40-60℃, and the specific temperature is adjusted according to the properties of the medicinal materials.

[0046] Time: Drying time is 12-24 hours, until the moisture content of the medicinal materials drops below 10%.

[0047] During drying, check the dryness of the medicinal materials regularly to avoid overheating and loss of active ingredients. Keep the drying equipment clean to avoid cross contamination. Record the temperature and time during the drying process for subsequent quality control.

[0048] S4. Crushing and grinding

[0049] Use a grinder to grind the dried medicinal materials until they are fine powder. Control the speed and grinding time of the grinder to avoid the loss of medicinal efficacy due to excessive grinding.

[0050] Equipment selection: Use a Chinese medicine crusher, such as a hammer mill or ball mill.

[0051] Particle size control: The particle size of the crushed medicinal materials is controlled at 100-120 meshes, and the specific particle size is adjusted according to the properties of the medicinal materials and usage requirements.

[0052] Avoid generating too much heat during the crushing process to avoid affecting the active ingredients of the medicinal materials. Check the wear of the crushing equipment regularly to ensure the crushing effect. Keep the crushing equipment clean to avoid cross contamination.

[0053] S5.Sieving

[0054] Use a fine sieve to sieve the mixed powder to remove the residue and larger particles to ensure the fineness and uniformity of the powder.

[0055] Equipment selection: Use a vibrating screen, such as a circular vibrating screen or a linear vibrating screen.

[0056] Screen selection: Use a 120 mesh screen to ensure consistent powder fineness.

[0057] S6. Packaging

[0058] Put the sieved powder into a dry, clean, well-sealed glass bottle or bag. Pay attention to sealing during the packaging process to prevent air and moisture from entering.

[0059] Material selection: Use moisture-proof and oxidation-proof packaging materials, such as aluminum foil bags or sealed bottles.

[0060] Packing quantity: 10-50 grams per pack or bottle according to usage requirements.

[0061] In order to further illustrate the technical solution of the present invention, the following embodiments are provided.

[0062] Example 1

[0063] S1. Material selection and proportion

[0064] The Chinese medicine composition is prepared according to the following weight: 15 grams of Epimedium, 15 grams of Clematis, 30 grams of Agrimoniae, 10 grams of Panax notoginseng, 8 grams of Leech, 30 grams of Astragalus, 15 grams of Dioscorea, 15 grams of Cornus, 115 grams of roasted malt, 6 grams of Safflower, 8 grams of Rhubarb, 20 grams of Raw Hawthorn, 5 grams of Licorice, 13 grams of Calamus, and 3 grams of Rosemary.

[0065] S2. Washing and drying

[0066] Select the raw materials of various medicinal materials that are free of insects, mildew, and impurities, wash them with clean water, and remove the dust and impurities on the surface. Spread the washed medicinal materials evenly in the sun to dry until the surface of the medicinal materials is dry and free of water droplets, but avoid excessive exposure to the sun to cause the loss of effective ingredients of the medicinal materials. The drying time is 1 day and the drying time is 8 hours.

[0067] S3. Drying

[0068] The dried medicinal materials were placed in a hot air circulation oven for drying. The temperature was controlled at 50° C. The drying time was 18 hours. The moisture content of the medicinal materials was 8%.

[0069] S4. Crushing and grinding

[0070] The dried medicinal materials are crushed with a hammer mill until they form a fine powder. The particle size of the crushed medicinal materials is controlled at 120 mesh.

[0071] S5.Sieving

[0072] Use a linear vibrating screen to sieve the mixed powder to remove drug residues and larger particles, and use a 120-mesh screen to ensure consistent powder fineness.

[0073] S6. Packaging

[0074] Put the sieved powder into a dry, clean, well-sealed aluminum foil bag. Pay attention to sealing during packaging to prevent air and moisture from entering. Each bottle contains 10 grams.

[0075] Example 2

[0076] S1. Material selection and proportion

[0077] The Chinese medicine composition is prepared according to the following weight: 15 grams of Epimedium, 20 grams of Clematis, 25 grams of Agrimoniae, 10 grams of Panax notoginseng, 10 grams of Leech, 25 grams of Astragalus, 15 grams of Dioscorea, 20 grams of Cornus, 12 grams of roasted malt, 6 grams of Safflower, 10 grams of Rhubarb, 15 grams of Hawthorn, 5 grams of Licorice, 15 grams of Calamus, and 2 grams of Rosemary.

[0078] S2. Washing and drying

[0079] Select the raw materials of various medicinal materials that are free of insects, mildew, and impurities, wash them with clean water, and remove the dust and impurities on the surface. Spread the washed medicinal materials evenly in the sun to dry until the surface of the medicinal materials is dry and free of water droplets, but avoid excessive exposure to the sun to cause the loss of effective ingredients of the medicinal materials. The drying time is 1 day and the drying time is 9 hours.

[0080] S3. Drying

[0081] The dried medicinal materials were placed in a hot air circulation oven for drying. The temperature was controlled at 60° C. The drying time was 12 hours. The moisture content of the medicinal materials was 9%.

[0082] S4. Crushing and grinding

[0083] The dried medicinal materials are crushed with a hammer mill until they form a fine powder. The particle size of the crushed medicinal materials is controlled at 110 mesh.

[0084] S5.Sieving

[0085] Use a circular vibrating screen to sieve the mixed powder to remove drug residues and larger particles, and use a 120-mesh screen to ensure consistent powder fineness.

[0086] S6. Packaging

[0087] Put the sieved powder into a dry, clean, well-sealed sealed bottle. Pay attention to sealing during packaging to prevent air and moisture from entering. Each bottle contains 10 grams.

[0088] Example 3

[0089] S1. Material selection and proportion

[0090] The Chinese medicine composition is prepared according to the following weight: 25 grams of Epimedium, 10 grams of Clematis, 30 grams of Agrimoniae, 15 grams of Panax notoginseng, 5 grams of Leech, 30 grams of Astragalus, 25 grams of Dioscorea, 10 grams of Cornus, 15 grams of roasted malt, 8 grams of Safflower, 6 grams of Rhubarb, 20 grams of Raw Hawthorn, 7 grams of Licorice, 15 grams of Calamus, and 3 grams of Rosemary.

[0091] S2. Washing and drying

[0092] Select the raw materials of various medicinal materials that are free of insects, mildew, and impurities, wash them with clean water, and remove the dust and impurities on the surface. Spread the washed medicinal materials evenly in the sun to dry until the surface of the medicinal materials is dry and free of water droplets, but avoid excessive exposure to the sun to cause the loss of effective ingredients of the medicinal materials. The drying time is 2 days, and the drying time is 7 hours per day.

[0093] S3. Drying

[0094] The dried medicinal materials were placed in a hot air circulation oven for drying. The temperature was controlled at 40° C. The drying time was 24 hours. The moisture content of the medicinal materials was 9%.

[0095] S4. Crushing and grinding

[0096] The dried medicinal materials are crushed with a ball mill until they form fine powder. The particle size of the crushed medicinal materials is controlled at 100 mesh.

[0097] S5.Sieving

[0098] Use a circular vibrating screen to sieve the mixed powder to remove drug residues and larger particles, and use a 120-mesh screen to ensure consistent powder fineness.

[0099] S6. Packaging

[0100] Put the sieved powder into a dry, clean, well-sealed aluminum foil bag. Pay attention to sealing during packaging to prevent air and moisture from entering. Each package contains 30 grams.

[0101] Example 4

[0102] S1. Material selection and proportion

[0103] The Chinese medicine composition is prepared according to the following weight: 25 grams of Epimedium, 20 grams of Clematis, 15 grams of Agrimoniae, 15 grams of Panax notoginseng, 10 grams of Leech, 15 grams of Astragalus, 25 grams of Dioscorea, 20 grams of Cornus, 10 grams of roasted malt, 8 grams of Safflower, 10 grams of Rhubarb, 10 grams of Raw Hawthorn, 7 grams of Licorice, 15 grams of Calamus, and 2 grams of Rosemary.

[0104] S2. Washing and drying

[0105] Select the raw materials of various medicinal materials that are free of insects, mildew, and impurities, wash them with clean water, and remove the dust and impurities on the surface. Spread the washed medicinal materials evenly in the sun to dry until the surface of the medicinal materials is dry and free of water droplets, but avoid excessive exposure to the sun to cause the loss of effective ingredients of the medicinal materials. The drying time is 2 days, and the drying time is 7 hours per day.

[0106] S3. Drying

[0107] The dried medicinal materials were placed in an infrared dryer for drying. The temperature was controlled at 40° C. The drying time was 12 hours. The moisture content of the medicinal materials was 7%.

[0108] S4. Crushing and grinding

[0109] The dried medicinal materials are crushed with a hammer mill until they form a fine powder. The particle size of the crushed medicinal materials is controlled at 1120 mesh.

[0110] S5.Sieving

[0111] Use a circular vibrating screen to sieve the mixed powder to remove drug residues and larger particles, and use a 120-mesh screen to ensure consistent powder fineness.

[0112] S6. Packaging

[0113] Put the sieved powder into a dry, clean, well-sealed sealed bottle. Pay attention to sealing during packaging to prevent air and moisture from entering. Each bottle contains 30 grams.

[0114] Example 5

[0115] S1. Material selection and proportion

[0116] The Chinese medicine composition is prepared according to the following weight: 30 grams of Epimedium, 10 grams of Clematis, 25 grams of Agrimoniae, 20 grams of Panax notoginseng, 5 grams of Leech, 20 grams of Astragalus, 30 grams of Dioscorea, 10 grams of Cornus, 12 grams of roasted malt, 10 grams of Safflower, 6 grams of Rhubarb, 15 grams of Hawthorn, 10 grams of Licorice, 10 grams of Calamus, and 3 grams of Rosemary.

[0117] S2. Washing and drying

[0118] Select the raw materials of various medicinal materials that are free of insects, mildew, and impurities, wash them with clean water, and remove the dust and impurities on the surface. Spread the washed medicinal materials evenly in the sun to dry until the surface of the medicinal materials is dry and free of water droplets, but avoid excessive exposure to the sun to cause the loss of effective ingredients of the medicinal materials. The drying time is 1 day, not 9 hours.

[0119] S3. Drying

[0120] The dried medicinal materials were placed in an infrared dryer for drying. The temperature was controlled at 50° C. The drying time was 18 hours. The moisture content of the medicinal materials was 6%.

[0121] S4. Crushing and grinding

[0122] The dried medicinal materials are crushed with a ball mill until they form fine powder. The particle size of the crushed medicinal materials is controlled at 100 mesh.

[0123] S5.Sieving

[0124] Use a circular vibrating screen to sieve the mixed powder to remove drug residues and larger particles, and use a 120-mesh screen to ensure consistent powder fineness.

[0125] S6. Packaging

[0126] Put the sieved powder into a dry, clean, well-sealed aluminum foil bag. Pay attention to sealing during packaging to prevent air and moisture from entering. Each package is 50 grams.

[0127] Example 6

[0128] S1. Material selection and proportion

[0129] The Chinese medicine composition is prepared according to the following weight: 30 grams of Epimedium, 15 grams of Clematis, 15 grams of Agrimoniae, 20 grams of Panax notoginseng, 7 grams of Leech, 15 grams of Astragalus, 30 grams of Dioscorea, 15 grams of Cornus, 10 grams of roasted malt, 10 grams of Safflower, 8 grams of Rhubarb, 10 grams of Hawthorn, 10 grams of Licorice, 13 grams of Calamus, and 2 grams of Rosemary.

[0130] S2. Washing and drying

[0131] Select the raw materials of various medicinal materials that are free of insects, mildew, and impurities, wash them with clean water, and remove the dust and impurities on the surface. Spread the washed medicinal materials evenly in the sun to dry until the surface of the medicinal materials is dry and free of water droplets, but avoid excessive exposure to the sun to cause the loss of effective ingredients of the medicinal materials. The drying time is 1 day and the drying time is 10 hours.

[0132] S3. Drying

[0133] The dried medicinal materials were placed in an infrared dryer for drying. The temperature was controlled at 60° C. The drying time was 12 hours. The moisture content of the medicinal materials was 5%.

[0134] S4. Crushing and grinding

[0135] The dried medicinal materials are crushed with a ball mill until they form fine powder. The particle size of the crushed medicinal materials is controlled at 120 mesh.

[0136] S5.Sieving

[0137] Use a circular vibrating screen to sieve the mixed powder to remove drug residues and larger particles, and use a 120-mesh screen to ensure consistent powder fineness.

[0138] S6. Packaging

[0139] Put the sieved powder into a dry, clean, well-sealed sealed bottle. Pay attention to sealing during packaging to prevent air and moisture from entering. Each bottle contains 50 grams.

[0140] Example 7

[0141] S1. Material selection and proportion

[0142] The Chinese medicine composition is prepared according to the following weight: 25 grams of Epimedium, 15 grams of Clematis, 25 grams of Agrimoniae, 15 grams of Panax notoginseng, 8 grams of Leech, 23 grams of Astragalus, 22 grams of Chinese yam, 15 grams of Cornus officinalis, 12 grams of roasted malt, 8 grams of safflower, 8 grams of rhubarb, 15 grams of raw hawthorn, 7 grams of liquorice, 12 grams of calamus, and 3 grams of rosemary.

[0143] S2. Washing and drying

[0144] Select the raw materials of various medicinal materials that are free of insects, mildew, and impurities, wash them with clean water, and remove the dust and impurities on the surface. Spread the washed medicinal materials evenly in the sun to dry until the surface of the medicinal materials is dry and free of water droplets, but avoid excessive exposure to the sun to cause the loss of effective ingredients of the medicinal materials. The drying time is 2 days, and the drying time is 7 hours per day.

[0145] S3. Drying

[0146] The dried medicinal materials were placed in a hot air circulation oven for drying. The temperature was controlled at 55° C. The drying time was 15 hours. The moisture content of the medicinal materials was 8%.

[0147] S4. Crushing and grinding

[0148] The dried medicinal materials are crushed with a ball mill until they form fine powder. The particle size of the crushed medicinal materials is controlled at 100 mesh.

[0149] S5.Sieving

[0150] Use a linear vibrating screen to sieve the mixed powder to remove drug residues and larger particles, and use a 120-mesh screen to ensure consistent powder fineness.

[0151] S6. Packaging

[0152] Put the sieved powder into a dry, clean, well-sealed sealed bottle. Pay attention to sealing during packaging to prevent air and moisture from entering. Each bottle contains 10 grams.

[0153] Comparative Example 1

[0154] Compared with Example 1, Comparative Example 1 does not add Astragalus, and the remaining components and preparation method are the same as those of Example 1.

[0155] Comparative Example 2

[0156] Compared with Example 1, Comparative Example 2 does not add yam, and the remaining components and preparation method are the same as those of Example 1.

[0157] Comparative Example 3

[0158] Compared with Example 1, Comparative Example 3 did not add Cornus officinalis, and the remaining components and preparation method were the same as those in Example 1.

[0159] Comparative Example 4

[0160] Compared with Example 1, Comparative Example 4 did not add Panax notoginseng, and the remaining components and preparation method were the same as those in Example 1.

[0161] Comparative Example 5

[0162] Compared with Example 1, Comparative Example 5 did not add leeches, and the remaining components and preparation method were the same as those of Example 1.

[0163] Comparative Example 6

[0164] Compared with Example 1, Comparative Example 6 did not add hawthorn, and the remaining components and preparation method were the same as those of Example 1.

[0165] Comparative Example 7

[0166] Compared with Example 1, Comparative Example 7 does not add safflower, and the remaining components and preparation method are the same as those of Example 1.

[0167] Comparative Example 8

[0168] Compared with Example 1, Comparative Example 8 did not add rhubarb, and the remaining components and preparation method were the same as those of Example 1.

[0169] Experimental Example 1: Treatment Effect Experiment

[0170] (1) Basic information:

[0171] 180 cases were observed clinically, aged 20-80 years old. Based on the differences in the treatment methods of the patients, the cases were divided into 9 groups, with 20 patients in each group. Specifically, there were 131 males and 49 females, with a male-to-female ratio of about 3:1. 32 cases were aged 40-50 years old, 87 cases were aged 50-65 years old, 46 cases were aged 65-75 years old, and 15 cases were over 75 years old; the course of disease was 15 days to 2 years; 85 of the 180 cases had symptoms of transient ischemic attacks such as dizziness, temporary slurred speech, limb disadvantages, and weakness, including 66 cases of long-term vertigo, dizziness, and headache, 42 cases of disadvantageous limb activity on one side, 36 cases of disadvantageous speech or crooked corners of the mouth, 60 cases of numbness in the hands or weakness in the legs, 85 cases with hypertension, 92 cases of hyperlipidemia, 40 cases with constipation, and 19 cases with Alzheimer's disease. All 180 cases were diagnosed by brain CT and MRI scans in the hospital and doctor's examinations.

[0172] (2) Diagnostic criteria:

[0173] Most patients have risk factors such as hypertension, hyperlipidemia or diabetes. Some patients may have symptoms of transient ischemic attack such as dizziness, headache, temporary limb numbness, weakness, hemiplegia, slurred speech, drooling, crooked mouth, etc.

[0174] The diagnosis can be confirmed by cranial CT examination in the ultra-early stage (within 6 hours of onset). CT can reveal some subtle early ischemic changes: such as high-density signs in the middle cerebral artery, unclear gray-white matter boundaries at the edge of the cortex (especially the insula) and the lentiform nucleus, and disappearance of brain sulci.

[0175] The diagnosis is confirmed by cranial MRI sequence examination, which can clearly show ischemic infarction, brainstem and cerebellar infarction, venous sinus thrombosis, etc., but is not sensitive to cerebral infarction within a few hours of onset.

[0176] (3) Usage and Dosage:

[0177] The first to ninth groups were orally administered with the preparations prepared in Example 1 and Comparative Examples 1-8, and one course of treatment was four weeks. For prevention of cerebral infarction, 5 g of the powder was taken each time (quantitative small spoon), and it was mixed into a paste with 100 ml of warm water at about 85 degrees, and taken warm 30 minutes after a meal.

[0178] Patients with cerebral infarction should take 1-3 courses of treatment. Those who are cured after one course of treatment can stop taking the medicine. Those who are not cured after one course of treatment should continue taking the second course of treatment.

[0179] (4) Efficacy criteria:

[0180] Cure: Symptoms of cerebral infarction disappear, and there is no recurrence after more than 1 year of follow-up. Brain CT or MRI examination is normal.

[0181] Improvement: Symptoms of cerebral infarction are alleviated or basically disappeared, and there is no aggravation or recurrence of symptoms during follow-up for more than 1 year. CT and MRI examinations of the head show that the cerebral ischemic lesions are reduced or shrunk.

[0182] Ineffective: Symptoms of cerebral infarction were not alleviated. No changes were found in the cerebral ischemic lesions by cranial CT and MRI examinations.

[0183] (5) Treatment effect:

[0184] After taking the Chinese medicine compositions in Example 1 and Comparative Examples 1 to 8 for 3 months, the specific efficacy of each group is shown in Table 1:

[0185] Table 1 Statistical table of therapeutic effects of each group of Chinese medicine compositions

[0186]

[0187] It can be seen that among the 180 cases using the embodiments and comparative examples, 25 cases were cured, accounting for 14%; 10 cases were improved, accounting for 6%. Among the ineffective cases, 1 case stopped taking the medicine on its own after taking the medicine for half a course of treatment without symptom relief, 2 cases stopped taking the medicine after one course of treatment because they felt it was ineffective, and the rest had no effect after using the Chinese medicine composition. Among the 180 cases of cerebral infarction, 25 cases were cured in an average of 60 days; 18 of them were cured after taking the medicine for one course of treatment (4 weeks), 4 cases were cured after taking the medicine for 2-4 courses of treatment, and 84 cases of improvement were effective after taking the medicine for one course of treatment. For 109 cases of cerebral infarction, this Chinese medicine composition was taken regularly for prevention after treatment, and no recurrence was observed after 1-2 years of follow-up.

[0188] In the cases of the embodiment, the Chinese medicine taken is the whole component, and the cure rate is the highest among all groups, so it can be shown that it has the effect of preventing and treating cerebral infarction. In other comparative examples, due to the lack of one monarch drug or ministerial drug, the overall effect is not obvious, so the cure rate is relatively low, but it can still be seen that it has a certain therapeutic effect.

[0189] Clinical Case 1

[0190] Patient Bai, male, 56 years old, an employee of a unit in Baota District, Yan'an City. He usually has high blood pressure, loves drinking and smoking, often has dizziness and headaches, and takes western medicine to relieve it every time, and it often attacks for about two years. Later, there was leakage from the corners of the mouth, drooling, numbness in the hands, and weakness in the left leg for more than a week. He was diagnosed with cerebral infarction in a certain hospital and received infusion treatment for half a month, and the dizziness and headache improved. He came to the doctor on September 12, 2018. His tongue was fat, his tongue was dark and stagnant, his tongue coating was white and greasy, and his pulse was thin and astringent. Chinese medicine diagnosed him with qi deficiency, phlegm and blood stasis. He took the Chinese medicine composition of the present invention twice a day. After one week, drooling and numbness in the corners of the mouth were relieved, and all symptoms disappeared after four weeks. After two months, the brain CT examination was cured.

[0191] Clinical Case 2

[0192] Patient Yang, female, 67 years old, an employee of a group company in Xi'an. The sequelae of cerebral infarction accompanied by Alzheimer's disease for one year. The patient was depressed, had crooked mouth and eyes, unclear speech, fuzzy memory, often could not recognize his children, and answered questions irrelevantly. He had been hospitalized for rehabilitation in Xi'an, and the medication of thrombolysis and blood stasis, and nutrition of cranial nerves was not effective. He came to the hospital for treatment in May 2020. His tongue was dark red with little coating, the sublingual veins were purple, and the pulse was deep and astringent. Chinese medicine diagnosis was liver and kidney yin deficiency, blood stasis, and marrow malnutrition. He was treated with the Chinese medicine composition of the present invention 3 times a day. After one month, the speech was alleviated. Although the speed of speech was slightly slow, he could communicate simply. His family was very happy. He continued to take four courses of treatment, and he could recognize people and read words. His face was splendid and his face was basically correct. After taking the Chinese medicine composition of the present invention, a small amount of prevention and consolidation was taken, and followed up for one year without recurrence.

[0193] Clinical Case 3

[0194] Patient Zhang, male, 37 years old, from Chang'an District, Xi'an. The patient usually likes to smoke and drink, loves to stay up late, often has dizziness, and the physical examination blood lipids are TG3.5, blood pressure is 160 / 100, and uric acid is 580. Later, there were frequent dizziness, discomfort in the back of the head, and stiff neck. He went to the hospital for examination and no cerebral infarction was found. But the doctor advised that there may be myocardial infarction and cerebral infarction at any time, so he asked him to treat it as soon as possible. The patient came to the hospital to take the Chinese medicine composition of the present invention. After three days, the dizziness was significantly relieved. After a week, the dizziness basically disappeared, the neck was stiff, and the discomfort in the back of the head was also relieved a lot. The symptoms disappeared after half a month. After taking it for two months, the examination indicators all dropped ideally, blood lipids were TG2.0, blood pressure was 130 / 88, and uric acid was 450. After another month of consolidation, follow-up for two years, everything was normal.

[0195] The Chinese medicine composition of the present invention has remarkable innovation, uniqueness and high efficiency in treating cerebral infarction, which is mainly reflected in the following aspects:

[0196] Theoretical innovation: At present, both traditional Chinese medicine and Western medicine generally use the methods of promoting blood circulation and removing blood stasis, and dissolving thrombus and clots in the clinical treatment of cerebral infarction. However, this single treatment method often ignores the overall condition of the patient and fails to fundamentally solve the problem. This application is different from traditional therapies. It uses the dialectical thinking of traditional Chinese medicine and innovatively proposes a comprehensive treatment idea of ​​"removing phlegm and blood stasis, unblocking meridians to treat symptoms; strengthening the body and eliminating evil, refreshing the brain and improving intelligence, strengthening the spleen and kidneys, and consolidating the basic essence to treat the root cause." While removing blood stasis and dissolving clots, more attention is paid to the root cause of strengthening the spleen and kidneys, nourishing qi and blood, and refreshing the brain, thereby effectively preventing the recurrence of cerebral infarction and the occurrence of cerebral atrophy.

[0197] Unique medication: Looking at the drugs for treating cerebral infarction clinically, whether it is traditional Chinese medicine or Western medicine, most of them focus on removing blood stasis and unblocking collaterals. The present invention starts with strengthening the spleen and kidney to consolidate the foundation, and at the same time combines drugs for removing blood stasis and unblocking collaterals, eliminating thrombus and dissolving plaques, and the prescription and medication are unique. This unique compatibility method not only effectively treats the symptoms of cerebral infarction, but also fundamentally improves the patient's physique and improves the treatment effect.

[0198] The compatibility principle of "monarch, minister, assistant and messenger": the "monarch medicine" of the present invention is the "three immortals", namely, Herba Cibotii, Herba Agrimoniae, and Herba Clematis. These three herbs, as monarch medicines, have significant effects on symptoms such as limb numbness, adverse meridians, hemiplegia, kidney deficiency and weak tendons, and adverse legs and feet caused by cerebral infarction. The "minister medicines" are Panax notoginseng, leech, hawthorn, safflower, and rhubarb, which are collectively "minister medicines" for removing blood stasis and unblocking meridians, which can remove blood stasis and eliminate spots without hurting the body. The "general" rhubarb is used to remove blood stasis and eliminate the old, and to support the old and bring forth the new. The "assistant medicines" are Polygala, Acorus calamus, Poria, and fried malt, which can strengthen the spleen and eliminate turbidity, calm the mind and improve intelligence, and clear the mind. The "messenger medicines" are rosemary and licorice, which aim to use fragrance to reach the clear orifices, reconcile various medicines, replenish without being dry, and disperse and have a tangible form.

[0199] Significant therapeutic effect: The present invention has significant therapeutic effect. It can be seen from the above embodiments and control experiments that its effect is significantly better than commonly used Western medicine and general Chinese medicine. Looking at the clinical treatment of cerebral infarction, whether Chinese medicine or Western medicine, most of them tend to remove blood stasis and dredge the meridians. The present invention utilizes the dialectical thinking of traditional Chinese medicine and innovatively proposes the comprehensive idea of ​​"removing phlegm and blood stasis, unblocking the meridians to treat the symptoms; strengthening the body and eliminating evil, refreshing the brain and improving intelligence, strengthening the spleen and kidneys, and consolidating the foundation to treat the root cause". While removing blood stasis and dissolving blood clots, it pays more attention to strengthening the spleen and kidneys, nourishing qi and blood, refreshing the brain and preventing blood clots and brain atrophy. Starting with strengthening the spleen and kidney and consolidating the foundation, combined with drugs that remove blood stasis, dredge the meridians, eliminate blood clots and dissolve plaques, the therapeutic effect is significant.

[0200] Rapid effect: Among the 180 observed cases, most patients showed significant improvement within a short period of time after taking the medicine. For example, 28 patients recovered after taking the medicine for one course of treatment (4 weeks), 40 patients recovered after taking the medicine for 2-4 courses of treatment, and 86 patients showed significant improvement in symptoms after taking the medicine for one course of treatment. These data show that the Chinese medicine composition can significantly improve the symptoms of cerebral infarction and relieve the pain of patients in a short period of time.

[0201] Shorten the treatment cycle: Traditional methods of treating cerebral infarction, whether it is Western medicine or general Chinese medicine, usually take a long time to see obvious effects. The Chinese medicine composition of the present invention combines the dual effects of removing blood stasis and dredge meridians and strengthening the spleen and kidney, which can achieve the effect of treating both the symptoms and the root causes in a shorter period of time. Specifically, the average healing time of 67 cured patients was 60 days, of which 28 cases were cured in only 4 weeks, and 40 cases were cured within 8-16 weeks. This shows that the Chinese medicine composition can quickly improve blood circulation, eliminate blood stasis, and restore blood supply to the brain, thereby accelerating the patient's recovery process.

[0202] Significant preventive effect: In addition to its significant therapeutic effect, the Chinese medicine composition of the present invention also performs well in preventing the recurrence of cerebral infarction. The results of a 1-2 year follow-up of cerebral infarction cases showed that all patients took the Chinese medicine composition regularly after treatment and no recurrence was observed. This result further proves the long-term effectiveness of the Chinese medicine composition in preventing cerebral infarction and provides continuous protection for patients.

[0203] In conclusion, the Chinese medicine composition of the present invention achieves the effect of treating both the symptoms and the root cause through the unique compatibility of Chinese medicines, and has significant advantages in the treatment and prevention of cerebral infarction. It is not only innovative and unique in theory and medication, but also highly efficient and fast in treatment time. This makes the Chinese medicine composition an ideal choice for the treatment of cerebral infarction, which can significantly shorten the patient's treatment cycle and improve the treatment efficiency. Its theoretical innovation, unique medication, and significant efficacy fully embody the characteristics of "effective, proven, and inexpensive" and "treating both the symptoms and the root cause" of Chinese medicine in treating diseases, and has great clinical promotion value.

Claims

1. A Chinese medicine composition for preventing and treating cerebral infarction, characterized in that: It is prepared from the following medicinal materials: Herba Epimedii, Radix Clematis, Herba Agrimoniae, Radix Notoginseng, Hirudo, Radix Astragali, Rhizoma Dioscoreae, Fructus Corni, Roasted Malt, Safflower, Rhubarb, Raw Hawthorn, Root of Licorice, Acorus Calamus, and Rosemary.

2. A Chinese medicine composition for preventing and treating cerebral infarction according to claim 1, characterized in that: The Chinese medicine composition is prepared from the following raw materials in parts by weight: 15-30 parts of epimedium, 10-20 parts of clematis, 15-30 parts of agrimony, 10-20 parts of notoginseng, 5-10 parts of leech, 15-30 parts of astragalus, 15-30 parts of yam, 10-20 parts of cornus, 10-15 parts of roasted malt, 6-10 parts of safflower, 6-10 parts of rhubarb, 10-20 parts of raw hawthorn, 5-10 parts of liquorice, 10-15 parts of calamus and 2-3 parts of rosemary.

3. A Chinese medicine composition for preventing and treating cerebral infarction according to claim 2, characterized in that: The Chinese medicine composition is prepared from the following raw materials in parts by weight: 25 parts of Herba Epimedii, 15 parts of Radix Clematis, 25 parts of Herba Agrimoniae, 15 parts of Radix Notoginseng, 8 parts of Hirudo, 23 parts of Radix Astragali, 22 parts of Dioscorea Oppositae, 15 parts of Fructus Corni, 12 parts of Roasted Malt, 8 parts of Safflower, 8 parts of Rhubarb, 15 parts of Raw Hawthorn, 7 parts of Licorice, 12 parts of Calamus and 3 parts of Rosemary.

4. The method for preparing a Chinese medicine composition for preventing and treating cerebral infarction according to claim 1, characterized in that: Follow the steps below to implement it: S1: Material selection and proportioning: proportion and mix the medicinal materials according to the above weight proportions; S2: Cleaning and drying: remove dust and impurities from the surface of the medicinal materials and dry them in the sun for 1-2 days; S3: Drying: Drying at a temperature range of 40-60°C until the moisture content of the medicinal materials drops below 10%; S4: Crushing and grinding: crushing the medicinal materials by a crusher; S5: sieving: filtering with a 120-mesh sieve to obtain drug powder; S6: Packaging.

5. The method for preparing a Chinese medicine composition for preventing and treating cerebral infarction according to claim 4, characterized in that: The daily drying time in S2 is not less than 6 hours.

6. The method for preparing a Chinese medicine composition for preventing and treating cerebral infarction according to claim 4, characterized in that: The drying time in S3 is 12-24 hours.

7. The method for preparing a Chinese medicine composition for preventing and treating cerebral infarction according to claim 6, characterized in that: In S3, the drying process is performed by using a hot air circulation oven or an infrared dryer.

8. The method for preparing a Chinese medicine composition for preventing and treating cerebral infarction according to claim 4, characterized in that: In the step S4, the pulverization and grinding is performed by a hammer mill or a ball mill.

9. The method for preparing a Chinese medicine composition for preventing and treating cerebral infarction according to claim 4, characterized in that: In the step S5, filtering is performed through a circular vibrating screen or a linear vibrating screen.

10. An application of a Chinese medicine composition for preventing and treating cerebral infarction, characterized in that: Take 4-6g of the Chinese medicine composition, mix it into a paste with warm water, and take it warm within 30 minutes after a meal; 1-3 times a day, four weeks as a course of treatment, which can play the role of preventing and treating cerebral infarction.

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