Double-conductive-path gel electrode patch and preparation method thereof

Abstract

The invention provides a double-conductive-path gel electrode patch and a preparation method thereof. The double-conductive-path gel electrode patch can be applied to the technical field of health sensing and monitoring. The preparation method of the double-conductive-path gel electrode patch comprises the following steps: dispersing polyvinyl alcohol, graphene oxide and ferric ion coordinated polydopamine in an aqueous solution to obtain a mixed solution; the mixed solution is injected into a mold, freezing and unfreezing circulation is carried out to enable the mixed solution to be in a gel state, the double-conductive-path gel electrode patch is obtained, and the freezing and unfreezing circulation comprises at least one time of freezing operation and at least one time of unfreezing operation.

Description

Technical Field

[0001] The present disclosure relates to the technical field of health sensor monitoring, and in particular to a gel electrode patch with dual conductive pathways and a preparation method thereof. Background Art

[0002] With the rapid development of artificial intelligence, wearable flexible electronic devices can realize real-time monitoring of motion information and physiological information. In order to obtain accurate physiological signals, the electrode patches used in wearable devices must have good adhesion and conductivity to the skin. However, the traditional gel electrode patches in related technologies have weak conductivity. Summary of the invention

[0003] In view of the above problems, the present disclosure provides a dual-conductive-path gel electrode patch and a preparation method thereof.

[0004] According to the first aspect of the present disclosure, there is provided a method for preparing a dual-conductive pathway gel electrode patch, comprising: dispersing polyvinyl alcohol, graphene oxide and polydopamine coordinated with trivalent iron ions in an aqueous solution to obtain a mixed solution; injecting the mixed solution into a mold, and performing a freeze-thaw cycle to make the mixed solution gel-like, thereby obtaining a dual-conductive pathway gel electrode patch, wherein the freeze-thaw cycle comprises at least one freezing operation and at least one thawing operation.

[0005] According to an embodiment of the present disclosure, the mass volume ratio of the polyvinyl alcohol, the graphene oxide and the polydopamine coordinated with trivalent iron ions is (0.9-1.1): (0.25-0.35): (0.45-0.55).

[0006] According to an embodiment of the present disclosure, the polyvinyl alcohol, graphene oxide and polydopamine coordinated with trivalent iron ions are dispersed in an aqueous solution to obtain a mixed solution, comprising: dispersing the polyvinyl alcohol in the aqueous solution when the temperature of the aqueous solution is 90°C, and dispersing the graphene oxide and polydopamine coordinated with trivalent iron ions in the aqueous solution when the temperature of the aqueous solution is room temperature.

[0007] According to an embodiment of the present disclosure, the temperature of the above-mentioned freezing operation is -20°C, and the duration of the above-mentioned freezing operation is 17 to 19 hours.

[0008] According to an embodiment of the present disclosure, the temperature of the above-mentioned thawing operation is 4° C., and the duration of the above-mentioned thawing operation is 5 to 7 hours.

[0009] A second aspect of the present disclosure provides a dual-conductive-pathway gel electrode patch prepared based on the above-mentioned dual-conductive-pathway gel electrode patch preparation method.

[0010] According to an embodiment of the present disclosure, the tensile deformation of the above-mentioned gel electrode patch is 200%~240%, and the compressive deformation of the above-mentioned gel electrode patch is 30%~50%.

[0011] According to the embodiment of the present disclosure, the maximum peeling force of the gel electrode patch is 1.2N / cm 2 .

[0012] According to an embodiment of the present disclosure, the time required for the above-mentioned gel electrode patch to repair itself after being broken is ≥10 minutes.

[0013] According to an embodiment of the present disclosure, when the frequency is 0-100 Hz, the resistance of the gel electrode patch is less than 2 kΩ.

[0014] A third aspect of the present disclosure provides an application of an electrode patch based on the above-mentioned dual conductive pathway in the field of physiological electrical signal acquisition.

[0015] According to the dual-conductive pathway gel electrode patch and the preparation method thereof provided by the present disclosure, polyvinyl alcohol, graphene oxide and polydopamine coordinated by trivalent iron ions are dispersed in an aqueous solution to obtain a mixed solution. The prepared mixed solution is injected into a mold by utilizing a template method, and a freeze-thaw cycle is performed to make the mixed solution gel-like, thereby obtaining a dual-conductive pathway gel electrode patch, thereby improving the production efficiency of the gel electrode patch. Moreover, since graphene oxide and polydopamine coordinated by trivalent iron ions are conductive, the prepared gel electrode patch has a dual-conductive pathway, thereby improving the conductivity of the gel electrode patch. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] The above and other objects, features and advantages of the present disclosure will become more apparent through the following description of the embodiments of the present disclosure with reference to the accompanying drawings, in which:

[0017] Figure 1 A flow chart schematically shows a method for preparing a gel electrode patch with dual conductive pathways according to an embodiment of the present disclosure;

[0018] Figure 2 The schematic diagram of the preparation process of the dual-conductive pathway gel electrode patch according to the embodiment of the present disclosure is schematically shown;

[0019] Figure 3A The mechanical schematic diagram of the gel electrode patch according to the embodiment of the present disclosure is schematically shown;

[0020] Figure 3B Schematically showing the strain diagrams of different gel electrode patches according to embodiments of the present disclosure;

[0021] Figure 3CSchematically showing the strain diagram of different freezing and thawing cycle numbers according to an embodiment of the present disclosure;

[0022] Figure 3D Schematically showing the strain diagram of different freezing and thawing cycle numbers according to another embodiment of the present disclosure;

[0023] Figure 4A The figure schematically shows a mechanical schematic diagram of a gel electrode patch according to another embodiment of the present disclosure;

[0024] Figure 4B Schematically showing the strain diagram of different gel electrode patches according to another embodiment of the present disclosure;

[0025] Figure 4C Schematically showing a strain diagram of different freezing and thawing cycle numbers according to another embodiment of the present disclosure;

[0026] Figure 4D Schematically showing a strain diagram of different freezing and thawing cycle times according to yet another embodiment of the present disclosure;

[0027] Figure 5A The schematic diagram of the peeling experiment of the gel electrode patch according to the embodiment of the present disclosure is schematically shown;

[0028] Figure 5B The schematic diagram of the peeling force of the gel electrode patch according to the embodiment of the present disclosure is schematically shown;

[0029] Figure 5C The schematic diagram of the peeling force of the gel electrode patch according to another embodiment of the present disclosure is schematically shown;

[0030] Fig. 6A A schematic diagram schematically shows that the gel electrode patch according to an embodiment of the present disclosure has conductivity;

[0031] Figure 6B A schematic diagram showing that a gel electrode patch according to another embodiment of the present disclosure has conductivity;

[0032] Figure 6C A schematic diagram schematically shows that a gel electrode patch according to another embodiment of the present disclosure has conductivity;

[0033] Fig.6D A schematic diagram schematically shows that a gel electrode patch according to another embodiment of the present disclosure has conductivity;

[0034] Fig. 7A A schematic diagram of the impedance of the gel electrode patch at different frequencies according to an embodiment of the present disclosure is schematically shown; and

[0035] Figure 7BThe impedance diagram of the gel electrode patch at different frequencies according to another embodiment of the present disclosure is schematically shown. DETAILED DESCRIPTION

[0036] Hereinafter, embodiments of the present disclosure will be described with reference to the accompanying drawings. However, it should be understood that these descriptions are exemplary only and are not intended to limit the scope of the present disclosure. In the following detailed description, for ease of explanation, many specific details are set forth to provide a comprehensive understanding of the embodiments of the present disclosure. However, it is apparent that one or more embodiments may also be implemented without these specific details. In addition, in the following description, descriptions of known structures and technologies are omitted to avoid unnecessary confusion of the concepts of the present disclosure.

[0037] The terms used herein are only for describing specific embodiments and are not intended to limit the present disclosure. The terms "comprise", "include", etc. used herein indicate the existence of the features, steps, operations and / or components, but do not exclude the existence or addition of one or more other features, steps, operations or components.

[0038] All terms (including technical and scientific terms) used herein have the meanings commonly understood by those skilled in the art unless otherwise defined. It should be noted that the terms used herein should be interpreted as having a meaning consistent with the context of this specification and should not be interpreted in an idealized or overly rigid manner.

[0039] When using expressions such as "at least one of A, B, and C, etc.", they should generally be interpreted according to the meaning of the expression commonly understood by those skilled in the art (for example, "a system having at least one of A, B, and C" should include but is not limited to a system having A alone, B alone, C alone, A and B, A and C, B and C, and / or A, B, C, etc.).

[0040] In the technical solution of the present disclosure, the user information (including but not limited to user personal information, user image information, user device information, such as location information, etc.) and data (including but not limited to data used for analysis, stored data, displayed data, etc.) involved are all information and data authorized by the user or fully authorized by all parties, and the collection, storage, use, processing, transmission, provision, disclosure and application of the relevant data comply with relevant laws, regulations and standards, take necessary confidentiality measures, do not violate public order and good morals, and provide corresponding operation entrances for users to choose to authorize or refuse.

[0041] In the process of realizing the present disclosure, it was found that the hydrogel prepared by the traditional method in the related art has weak conductivity, and its actual use in signal monitoring is very difficult because of its lack of conductivity. The filling of the conductive filler is just a simple physical and mechanical mixture. The lack of chemical bonding ability makes the dispersion of the conductive material uneven, which will also have a greater impact on the mechanical properties of traditional elastic polymers. Traditional elastic polymers are weak in themselves because they are hindered by insufficient mechanical strength and high Young's modulus and cannot be assimilated with the skin. At the same time, the electrode patch in the related art is prone to cause severe allergic reactions on sensitive skin due to its lack of biocompatibility. Therefore, its application in the actual process is limited. Compared with conductive fillers, the new conductive polymer is more similar to human skin, but is also limited by its significant brittleness, which also hinders practical application.

[0042] In view of this, an embodiment of the present disclosure provides a method for preparing a dual-conductive path gel electrode patch, comprising: dispersing polyvinyl alcohol, graphene oxide and polydopamine coordinated with trivalent iron ions in an aqueous solution to obtain a mixed solution; injecting the mixed solution into a mold, and performing a freeze-thaw cycle to make the mixed solution gel-like, thereby obtaining a dual-conductive path gel electrode patch, wherein the freeze-thaw cycle includes at least one freezing operation and at least one thawing operation.

[0043] Figure 1 The flowchart of the method for preparing the dual conductive pathway gel electrode patch according to the embodiment of the present disclosure is schematically shown.

[0044] like Figure 1 As shown, the method 100 for preparing the dual conductive path gel electrode patch of this embodiment includes operation S110 and operation S120.

[0045] In operation S110, polyvinyl alcohol, graphene oxide, and polydopamine coordinated with trivalent iron ions are dispersed in an aqueous solution to obtain a mixed solution.

[0046] In operation S120, the mixed solution is injected into a mold, and a freeze-thaw cycle is performed to make the mixed solution gel-like, thereby obtaining a gel electrode patch with dual conductive pathways.

[0047] According to the embodiments of the present disclosure, polyvinyl alcohol (PVA) is a high molecular polymer, generally a white or slightly yellow powder or granular solid, with good water solubility. The molecular structure of polyvinyl alcohol is composed of many repeated vinyl alcohol units. Graphene oxide (GO) is a type of derivative in the process of graphite to graphene transformation, and is a two-dimensional structure nanomaterial with a single atomic layer thickness. Polydopamine coordinated by trivalent iron ions (PDA-Fe 3+) is a composite material composed of polydopamine (PDA) and trivalent iron ions (Fe³⁺).

[0048] According to an embodiment of the present disclosure, polyvinyl alcohol, graphene oxide, and polydopamine coordinated with trivalent iron ions may be dispersed in an aqueous solution to obtain a mixed solution, which is a viscous solution.

[0049] According to the embodiments of the present disclosure, a configured mixed solution can be obtained when the mass volume ratio of polyvinyl alcohol, graphene oxide and polydopamine coordinated by trivalent iron ions is determined. The configured mixed solution can be injected into a mold using a template method. Among them, the mold can be made according to demand, and the shape and thickness of the mold can be customized according to demand. For example, the mold can be rectangular, square, circular, irregular, etc.

[0050] According to an embodiment of the present disclosure, the freezing operation of the mixed solution can be completed by placing the mixed solution in the freezing layer of a refrigerator, and the freezing operation of the mixed solution can be completed by placing the mixed solution in the refrigeration layer of a refrigerator. In addition, the freezing and thawing cycle of the mixed solution can also be completed by running a freezing and thawing program. By performing a freezing and thawing cycle on the mold injected with the mixed solution, the mixed solution can be made into a gel state, and since the polydopamine coordinated by graphene oxide and trivalent iron ions has conductivity, a gel electrode patch with a dual conductive pathway is obtained.

[0051] According to an embodiment of the present disclosure, the freeze-thaw cycle includes at least one freezing operation and at least one thawing operation, and the freezing operation and the thawing operation are performed alternately. For example, the freeze-thaw cycle can be three times, i.e., freezing, thawing, freezing, thawing, freezing, and thawing. For another example, the freeze-thaw cycle can also be two times, i.e., freezing, thawing, freezing, and thawing. Thawing is required after each freezing, and the last operation before obtaining the gel electrode patch with a dual conductive path is a thawing operation.

[0052] Figure 2 The schematic diagram shows the preparation process of the dual conductive pathway gel electrode patch according to an embodiment of the present disclosure.

[0053] like Figure 2As shown, the preparation process of the dual conductive pathway gel electrode patch includes dispersing polyvinyl alcohol, graphene oxide and polydopamine coordinated by trivalent iron ions in an aqueous solution to obtain a mixed solution 210, injecting the prepared mixed solution 210 into a mold 220 by a template method, and subjecting the mold 220 with the mixed solution 210 to a freeze-thaw cycle to make the mixed solution gel-like, thereby obtaining a dual conductive pathway gel electrode patch. The cross-linking bonding of hydrogen bonds can be seen from the theoretical model 230 of the dual conductive pathway gel electrode patch. The freezing operation temperature can be -20°C, the freezing operation duration is 18 hours, and the thawing operation temperature can be 4°C, and the thawing operation duration is 6 hours.

[0054] According to the embodiments of the present disclosure, polyvinyl alcohol, graphene oxide and polydopamine coordinated by trivalent iron ions are dispersed in an aqueous solution to obtain a mixed solution. The configured mixed solution is injected into a mold by utilizing a template method, and a freeze-thaw cycle is performed to make the mixed solution gel-like, thereby obtaining a gel electrode patch with a dual conductive path, thereby improving the production efficiency of the gel electrode patch. Moreover, since graphene oxide and polydopamine coordinated by trivalent iron ions are conductive, the prepared gel electrode patch has a dual conductive path, thereby improving the conductivity of the gel electrode patch.

[0055] According to an embodiment of the present disclosure, the mass volume ratio of polyvinyl alcohol, graphene oxide and polydopamine coordinated by trivalent iron ions can be (0.9-1.1): (0.25-0.35): (0.45-0.55). Different mass volume ratios of polyvinyl alcohol, graphene oxide and polydopamine coordinated by trivalent iron ions can obtain different mixed solutions.

[0056] For example, the mass volume ratio of polyvinyl alcohol, graphene oxide and polydopamine coordinated with trivalent iron ions can be 0.1:0.3:0.5.

[0057] According to an embodiment of the present disclosure, polyvinyl alcohol, graphene oxide and polydopamine coordinated by trivalent iron ions are dispersed in an aqueous solution to obtain a mixed solution, comprising:

[0058] When the temperature of the aqueous solution is 90° C., polyvinyl alcohol is dispersed in the aqueous solution, and when the temperature of the aqueous solution is room temperature, graphene oxide and polydopamine coordinated with trivalent iron ions are dispersed in the aqueous solution.

[0059] According to an embodiment of the present disclosure, when the mass-to-volume ratio of polyvinyl alcohol, graphene oxide and polydopamine coordinated with trivalent iron ions is determined, polyvinyl alcohol can be dispersed in an aqueous solution at 90°C, and graphene oxide and polydopamine coordinated with trivalent iron ions can be dispersed in an aqueous solution at room temperature, thereby obtaining a mixed solution.

[0060] According to an embodiment of the present disclosure, the solubility of polyvinyl alcohol, graphene oxide and polydopamine coordinated with trivalent iron ions can be improved by dispersing polyvinyl alcohol in an aqueous solution when the temperature of the aqueous solution is 90°C and dispersing graphene oxide and polydopamine coordinated with trivalent iron ions in an aqueous solution when the temperature of the aqueous solution is room temperature.

[0061] According to an embodiment of the present disclosure, the temperature of the freezing operation can be -20°C, and the duration of the freezing operation can be 17 to 19 hours.

[0062] According to an embodiment of the present disclosure, the mixed solution can be placed in a freezer layer of a refrigerator, and the freezing operation temperature is -20°C, and the freezing operation time can be 17 to 19 hours. For example, the freezing operation time can be 18 hours.

[0063] According to an embodiment of the present disclosure, the temperature of the thawing operation may be 4° C., and the duration of the thawing operation may be 5 to 7 hours.

[0064] According to an embodiment of the present disclosure, after the mixed solution is frozen, the frozen mixed solution can be placed in a cold storage layer of a refrigerator, and the temperature of the thawing operation is -4°C. The mixed solution after thawing is in a gel state, and the thawing operation time is 5 to 7 hours. For example, the thawing operation time can be 6 hours.

[0065] According to an embodiment of the present disclosure, by injecting the configured mixed solution into a mold and performing a freeze-thaw cycle, as the number of freeze-thaw cycles gradually increases, the gel-like electrode iron sheet will shrink, so the number of freeze-thaw cycles can be three.

[0066] According to an embodiment of the present disclosure, by using a template method to inject a mixed solution of vinyl alcohol, graphene oxide and polydopamine coordinated with trivalent iron ions in a mass volume ratio of (0.9~1.1): (0.25~0.35): (0.45~0.55) into a mold, and performing a predetermined number of freeze-thaw cycles, the mixed solution can be made into a gel state, thereby obtaining a gel electrode patch with a dual conductive path. Among them, the temperature of the freezing operation is -20°C, the duration of the freezing operation is 17~19 hours, the temperature of the thawing operation is 4°C, and the duration of the thawing operation is 5~7 hours, which improves the preparation efficiency of the gel electrode patch and improves the conductivity of the gel electrode patch.

[0067] Preparation method of gel electrode patch with dual conductive pathways based on the above-mentioned preparation method of gel electrode patch with dual conductive pathways The present disclosure also provides a gel electrode patch with dual conductive pathways prepared based on the above-mentioned preparation method of gel electrode patch with dual conductive pathways.

[0068] According to an embodiment of the present disclosure, the tensile deformation of the gel electrode patch is 200% to 240%, and the compressive deformation of the gel electrode patch is 30% to 50%.

[0069] According to an embodiment of the present disclosure, the strain of the gel electrode patch may include tensile deformation and compressive deformation. By stretching or compressing the gel electrode patch, the tensile deformation of the gel electrode patch can reach 240%, and the compressive deformation of the gel electrode patch can reach 50%.

[0070] Figure 3A The mechanical schematic diagram of the gel electrode patch according to the embodiment of the present disclosure is schematically shown. Figure 3B The strain diagrams of different gel electrode patches according to the embodiments of the present disclosure are schematically shown. Figure 3C The strain diagram of different freezing and thawing cycle numbers according to an embodiment of the present disclosure is schematically shown. Figure 3D The strain diagram of different freezing and thawing cycle numbers according to another embodiment of the present disclosure is schematically shown.

[0071] like Figure 3A As shown in FIG. 1 , a tensile force is applied to the gel electrode patch, and the tensile force is F. Figure 3B As shown, the strains of the gel electrode patch made of a single material polyvinyl alcohol (PVA), the gel electrode patch made of polyvinyl alcohol and graphene oxide (PVA / GO), and the gel electrode patch made of polyvinyl alcohol, graphene oxide and polydopamine coordinated with trivalent iron ions (PVA / GO / PDA-Fe3+, referred to as PGF) under different loads respectively. It can be seen that the maximum tensile deformation of the gel electrode patch can be greater than 200%, and under the same tensile variable, the load of the gel electrode patch made of polyvinyl alcohol, graphene oxide and polydopamine coordinated with trivalent iron ions is greater than that of the gel electrode patch made of a single material polyvinyl alcohol, the gel electrode patch made of polyvinyl alcohol and graphene oxide, and the gel electrode patch made of polyvinyl alcohol, graphene oxide and polydopamine coordinated with trivalent iron ions. As Figure 3C As shown in the figure, the strain of gel electrode patches prepared with freeze-thaw cycles ranging from 1 to 6, 6 to 10, 11 to 15, 16 to 20, and 21 to 25 under different loads, it can be seen that under different freeze-thaw cycle ranges, they can have stable tensile deformation within a certain range, and the maximum tensile deformation can reach 240%. Figure 3DAs shown, the freeze-thaw cycle times range from 1 and 2 to 20 times respectively. It can be seen that when the freeze-thaw cycle times is 1, the gel electrode patch can have a stable tensile deformation, and when the freeze-thaw cycle times range from 2 to 20 times, the gel electrode patch can also have a stable tensile deformation, and the maximum tensile deformation can reach 240%.

[0072] Figure 4A The figure schematically shows a mechanical diagram of a gel electrode patch according to another embodiment of the present disclosure. Figure 4B The strain diagram of different gel electrode patches according to another embodiment of the present disclosure is schematically shown. Figure 4C The strain diagram of different freezing and thawing cycle numbers according to another embodiment of the present disclosure is schematically shown. Figure 4D The strain diagram of different freezing and thawing cycle numbers according to another embodiment of the present disclosure is schematically shown.

[0073] like Figure 4A As shown in the figure, a compressive force is applied to the gel electrode patch, and the compressive force is F. Figure 4B As shown, the strains of the gel electrode patch made of a single material polyvinyl alcohol (PVA), the gel electrode patch made of polyvinyl alcohol and graphene oxide (PVA / GO), and the gel electrode patch made of polyvinyl alcohol, graphene oxide and polydopamine coordinated with trivalent iron ions (PVA / GO / PDA-Fe3+) under different pressures respectively. It can be seen that the maximum compression deformation of the gel electrode patch can reach 50%, and under the same tension and compression variables, the pressure of the gel electrode patch made of polyvinyl alcohol, graphene oxide and polydopamine coordinated with trivalent iron ions is greater than that of the gel electrode patch made of a single material polyvinyl alcohol, the gel electrode patch made of polyvinyl alcohol and graphene oxide, and the gel electrode patch made of polyvinyl alcohol, graphene oxide and polydopamine coordinated with trivalent iron ions. As shown in FIG. Figure 3C As shown in the figure, the strain of gel electrode patches prepared with freeze-thaw cycles ranging from 1 to 6, 6 to 10, 11 to 15, 16 to 20, and 21 to 25 under different pressures, it can be seen that under different freeze-thaw cycle ranges, the compressive deformation can be stable within a certain range, and the maximum compressive deformation can reach 50%. Figure 3D As shown, the freeze-thaw cycle times range from 1 and 2 to 20 times respectively. It can be seen that when the freeze-thaw cycle times is 1, the gel electrode patch can have a stable compression deformation amount, and when the freeze-thaw cycle times range from 2 to 20 times, the gel electrode patch can also have a stable compression deformation amount, and the maximum compression deformation amount can reach 50%.

[0074] According to the embodiment of the present disclosure, the maximum peeling force of the gel electrode patch is 1.2N / cm 2 .

[0075] According to the embodiment of the present disclosure, by adhering the gel electrode patch to the surface of the pig skin, the gel electrode patch can be well adhered to the surface of the pig skin, and the upper and lower sides can be peeled off using a universal mechanical machine. The maximum peeling force of the gel electrode patch adhering to the surface of the pig skin can reach 1.2N / cm 2 .

[0076] According to the embodiments of the present disclosure, since the gel electrode patch has a large peeling force on the skin surface and is not easily peeled off, it can provide favorable conditions for long-term physiological electrical signal monitoring.

[0077] Figure 5A The schematic diagram of the peeling experiment of the gel electrode patch according to the embodiment of the present disclosure is schematically shown. Figure 5B The schematic diagram of the peeling force of the gel electrode patch according to the embodiment of the present disclosure is schematically shown. Figure 5C The schematic diagram of the peeling force of the gel electrode patch according to another embodiment of the present disclosure is schematically shown.

[0078] like Figure 5A As shown in the figure, the gel electrode patch was adhered to the surface of the pig skin, and a peeling experiment was performed on the upper and lower sides of the gel electrode patch using a universal mechanical machine. Figure 5B As shown, the peeling force corresponding to different moving positions of the gel electrode patch (PVA) prepared from a single material polyvinyl alcohol and the gel electrode patch (PGF) prepared from polyvinyl alcohol, graphene oxide and polydopamine coordinated with trivalent iron ions during the glass experiment using a universal mechanical machine. It can be seen that the maximum peeling force of the gel electrode patch prepared from a single material polyvinyl alcohol is smaller than the maximum peeling force of the gel electrode patch prepared from polyvinyl alcohol, graphene oxide and polydopamine coordinated with trivalent iron ions. The maximum peeling force of the gel electrode patch prepared from polyvinyl alcohol, graphene oxide and polydopamine coordinated with trivalent iron ions can reach 1.2 N / cm 2 .like Figure 5C As shown in the figure, it is another representation of the peeling force corresponding to different moving positions of the gel electrode patch (PVA) prepared from a single material polyvinyl alcohol and the gel electrode patch (PGF) prepared from polyvinyl alcohol, graphene oxide and polydopamine coordinated with trivalent iron ions during the glass experiment using a universal mechanical machine. It can be seen that the maximum peeling force of the gel electrode patch prepared from a single material polyvinyl alcohol is smaller than the maximum peeling force of the gel electrode patch prepared from polyvinyl alcohol, graphene oxide and polydopamine coordinated with trivalent iron ions. The maximum peeling force of the gel electrode patch prepared from polyvinyl alcohol, graphene oxide and polydopamine coordinated with trivalent iron ions can reach 1.2 N / cm2 .

[0079] According to an embodiment of the present disclosure, the time required for the gel electrode patch to repair itself after being broken is ≥ 10 minutes.

[0080] According to the embodiment of the present disclosure, the gel electrode patch has the ability to conduct electricity, and the LED light can be turned on by connecting the gel electrode patch to the LED light. After the gel electrode patch is broken, the LED light is disconnected and the LED light is turned off.

[0081] According to an embodiment of the present disclosure, the gel electrode patch can repair itself by leaving the broken gel electrode patch to stand for a period of time. The time required for the gel electrode patch to repair itself after breaking is greater than or equal to 10 minutes. For example, the time required for the gel electrode patch to repair itself after breaking can be 15 minutes. The self-repaired gel electrode patch is connected to an LED, and the LED light can be re-lit. Therefore, the gel electrode patch has good self-repairing ability.

[0082] According to the embodiments of the present disclosure, since the broken gel electrode patch can repair itself after being left standing for a period of time, it is beneficial to maintain long-term monitoring of electrophysiological signals.

[0083] Fig. 6A The schematic diagram schematically shows that the gel electrode patch according to the embodiment of the present disclosure has conductivity. Figure 6B The schematic diagram schematically shows that the gel electrode patch according to another embodiment of the present disclosure has conductivity. Figure 6C The schematic diagram schematically shows that the gel electrode patch according to another embodiment of the present disclosure has conductivity. Fig.6D A schematic diagram showing that a gel electrode patch according to another embodiment of the present disclosure has conductivity is shown.

[0084] like Fig. 6A As shown in the figure, it is a circuit diagram of the LED circuit without the gel electrode patch connected and a schematic diagram of the LED being lit. Figure 6B As shown in the figure, it is a circuit diagram of the light-emitting diode circuit connected to the gel electrode patch and a schematic diagram of the light-emitting diode being lit. Figure 6C As shown in FIG. 1 , it is a circuit diagram of a case where the gel electrode patch connected to the light-emitting diode circuit is broken and a schematic diagram of a light-emitting diode circuit not being lit. Fig.6D As shown, it is a circuit diagram of the gel electrode patch connected to the light-emitting diode circuit in the case of self-repair and a schematic diagram of the light-emitting diode being lit.

[0085] Combination Figure 6A~6DIt can be seen that the gel electrode patch has the ability to conduct electricity, and after being left to stand for a period of time after being broken, the gel electrode patch can repair itself, and the repaired gel electrode patch still has the ability to conduct electricity. Therefore, the gel electrode patch has the ability to self-repair.

[0086] According to an embodiment of the present disclosure, when the frequency is 0-100 Hz, the resistance of the gel electrode patch is less than 2 kΩ.

[0087] According to the embodiments of the present disclosure, by analyzing the gel electrode patch at different frequencies, within the frequency range of 0 to 100 Hz, the gel electrode patch has a lower resistance at each frequency, and the resistance at various frequencies is lower than 2 kΩ.

[0088] According to the embodiments of the present disclosure, since the resistance of the gel electrode patch in the frequency range of 0-100 Hz is lower than 2 kΩ, the gel electrode patch exhibits excellent electrochemical performance.

[0089] Fig. 7A The impedance diagram of the gel electrode patch at different frequencies according to an embodiment of the present disclosure is schematically shown. Figure 7B The impedance diagram of the gel electrode patch at different frequencies according to another embodiment of the present disclosure is schematically shown.

[0090] like Fig. 7A As shown, it is a schematic diagram of the impedance of the gel electrode patch in the frequency range of 0~100Hz, including a gel electrode patch (PVA) made of a single material polyvinyl alcohol, a gel electrode patch made of polyvinyl alcohol and graphene oxide (PVA / GO), and a gel electrode patch made of polyvinyl alcohol, graphene oxide and polydopamine coordinated with trivalent iron ions (PVA / GO / PDA-Fe3+). It can be seen that the impedance of the gel electrode patch prepared by polyvinyl alcohol, graphene oxide and polydopamine coordinated with trivalent iron ions in the frequency range of 0~100Hz is always less than 2kΩ, and at the same frequency, the impedance of the gel electrode patch prepared by polyvinyl alcohol, graphene oxide and polydopamine coordinated with trivalent iron ions is less than the impedance of the gel electrode patch prepared by a single material polyvinyl alcohol and the gel electrode patch prepared by polyvinyl alcohol and graphene oxide. Therefore, the gel electrode exhibits excellent electrochemical performance in the frequency range of 0~100Hz. Figure 7B As shown, Fig. 7AThe impedance diagram of the middle frequency range of 0~log(4.5)Hz includes gel electrode patches made of single material polyvinyl alcohol (PVA), gel electrode patches made of polyvinyl alcohol and graphene oxide (PVA / GO), and gel electrode patches made of polyvinyl alcohol, graphene oxide and polydopamine coordinated with trivalent iron ions (PVA / GO / PDA-Fe3+). It can be seen that the impedance of the gel electrode patch made of polyvinyl alcohol, graphene oxide and polydopamine coordinated with trivalent iron ions is always less than 2kΩ in the frequency range of 0~log(4.5)Hz, and at the same frequency, the impedance of the gel electrode patch made of polyvinyl alcohol, graphene oxide and polydopamine coordinated with trivalent iron ions is less than the impedance of the gel electrode patch made of single material polyvinyl alcohol and the gel electrode patch made of polyvinyl alcohol and graphene oxide.

[0091] According to the embodiments of the present disclosure, the dual-conductive-path gel electrode patch prepared by the preparation method of the dual-conductive-path gel electrode patch has good mechanical strength, the maximum strain can reach more than 50%, and it can maintain good mechanical strength during multiple cycles of stretching and extrusion. The elastic modulus equivalent to the skin is conducive to better fitting with the skin tissue; the gel electrode patch also has good adhesion ability and is more closely connected to the skin tissue, which is conducive to the measurement of more accurate parameters; the dual-path conductivity of the gel electrode patch enables it to have good electrical signal conduction ability, and the stable electrochemical sensing ability of the gel electrode patch can achieve stable long-term monitoring, and a certain self-repair ability is conducive to increasing the service life of the material. In addition, the gel electrode patch also has good biocompatibility, which is conducive to long-term signal monitoring without causing obvious inflammatory reactions.

[0092] The flow charts and block diagrams in the accompanying drawings illustrate the possible architecture, functions and operations of the systems, methods and computer program products according to various embodiments of the present disclosure. In this regard, each box in the flow chart or block diagram can represent a module, a program segment, or a part of a code, and the above-mentioned module, program segment, or a part of a code contains one or more executable instructions for realizing the specified logical function. It should also be noted that in some alternative implementations, the functions marked in the box can also occur in a different order from the order marked in the accompanying drawings. For example, two boxes represented in succession can actually be executed substantially in parallel, and they can sometimes be executed in the opposite order, depending on the functions involved. It should also be noted that each box in the block diagram or flow chart, and the combination of the boxes in the block diagram or flow chart can be implemented with a dedicated hardware-based system that performs a specified function or operation, or can be implemented with a combination of dedicated hardware and computer instructions.

[0093] It will be appreciated by those skilled in the art that the features described in the various embodiments of the present disclosure may be combined and / or combined in a variety of ways, even if such combinations and / or combinations are not explicitly described in the present disclosure. In particular, without departing from the spirit and teachings of the present disclosure, the features described in the various embodiments of the present disclosure may be combined and / or combined in a variety of ways. All of these combinations and / or combinations fall within the scope of the present disclosure.

[0094] The embodiments of the present disclosure are described above. However, these embodiments are only for illustrative purposes and are not intended to limit the scope of the present disclosure. Although the embodiments are described above separately, this does not mean that the measures in the various embodiments cannot be used in combination to advantage. Without departing from the scope of the present disclosure, those skilled in the art may make a variety of substitutions and modifications, which should all fall within the scope of the present disclosure.

Claims

1. A method for preparing a dual-conductive path gel electrode patch, characterized in that: include: Dispersing polyvinyl alcohol, graphene oxide and polydopamine coordinated with trivalent iron ions in an aqueous solution to obtain a mixed solution; The mixed solution is injected into a mold, and a freeze-thaw cycle is performed to make the mixed solution gel-like, thereby obtaining a gel electrode patch with dual conductive pathways, wherein the freeze-thaw cycle includes at least one freezing operation and at least one thawing operation.

2. The method according to claim 1, characterized in that The mass volume ratio of the polyvinyl alcohol, the graphene oxide and the polydopamine coordinated with trivalent iron ions is (0.9-1.1): (0.25-0.35): (0.45-0.55).

3. The method according to claim 1, characterized in that: The method comprises dispersing polyvinyl alcohol, graphene oxide and polydopamine coordinated with trivalent iron ions in an aqueous solution to obtain a mixed solution, comprising: When the temperature of the aqueous solution is 90° C., the polyvinyl alcohol is dispersed in the aqueous solution. When the temperature of the aqueous solution is room temperature, the graphene oxide and the polydopamine coordinated with the trivalent iron ion are dispersed in the aqueous solution.

4. The method according to claim 1, characterized in that: The temperature of the freezing operation is -20°C, and the duration of the freezing operation is 17 to 19 hours.

5. The method according to claim 1, characterized in that The temperature of the thawing operation is 4° C., and the duration of the thawing operation is 5 to 7 hours.

6. A dual-conductive path gel electrode patch prepared by the preparation method according to any one of claims 1 to 5.

7. The gel electrode patch according to claim 6, characterized in that: The tensile deformation of the gel electrode patch is 200% to 240%, and the compressive deformation of the gel electrode patch is 30% to 50%.

8. The gel electrode patch according to claim 6, characterized in that: The maximum peeling force of the gel electrode patch is 1.2 N / cm 2 .

9. The gel electrode patch according to claim 6, characterized in that: The time required for the gel electrode patch to repair itself after being broken is ≥10 minutes.

10. The gel electrode patch according to claim 6, characterized in that: When the frequency is 0-100 Hz, the resistance of the gel electrode patch is less than 2 kΩ.

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