High-resolution laser ophthalmology diagnostic instrument system and detection method thereof

Abstract

The invention discloses a high-resolution laser ophthalmology diagnostic instrument system which comprises a spectroscope, a collimation imaging mechanism is arranged on the light source leading-in side of the spectroscope, a light source of the light source mechanism is led in through the collimation imaging mechanism, and the detection side of the spectroscope is divided into two paths, one path is sequentially and optically connected with a synchronous radiography mechanism and a detector mechanism according to the light emitting direction, the other path is sequentially and optically connected with a scanning imaging mechanism, an eyepiece mechanism and an eyepiece adjusting mechanism according to the light emitting direction, and the scanning imaging mechanism is further optically connected with an internal fixation mechanism; the light source mechanism is used for providing light sources with different wavelengths. The invention discloses a high-resolution laser ophthalmology diagnostic instrument system and a detection method thereof. The system can be used for synchronous radiography to obtain radiography images of a plurality of structures of eyes.

Description

Technical Field

[0001] The present invention relates to the technical field of optical equipment, and in particular to a high-resolution laser ophthalmology diagnostic instrument system and a detection method thereof. Background Art

[0002] Laser ophthalmology diagnostic equipment uses laser scanning to capture fundus images and can see static images such as retinal blood vessels, regardless of the patient's refractive state, including myopia, hyperopia and astigmatism, and different requirements for the level of detail of the eye structure and the type of lesions. High resolution is very important in fine structure imaging and lesion detection. To support accurate ophthalmic diagnosis, the equipment needs to be able to provide consistent high-resolution images.

[0003] Refractive adjustment is usually achieved by adjusting the lens system or using a refractive adjustment module. Traditional adjustment methods are complex to maintain high image quality under different refractive conditions. Refractive problems beyond the range (such as high myopia or high hyperopia) may not be effectively compensated, and cannot respond to changes in the patient's eye refractive state in real time, affecting imaging or correction effects. Summary of the invention

[0004] The present invention overcomes the shortcomings of the prior art and provides a high-resolution laser ophthalmology diagnostic instrument system and a detection method thereof; the system can be used for synchronous imaging to obtain imaging images of multiple structures of the eye.

[0005] To achieve the above-mentioned purpose, the technical solution adopted by the present invention is: a high-resolution laser ophthalmology diagnostic instrument system, the laser ophthalmology diagnostic instrument comprises: a spectroscope, a collimating imaging mechanism is arranged on the light source introduction side of the spectroscope, and the light source of the light source mechanism is introduced through the collimating imaging mechanism, the detection side of the spectroscope is divided into two paths, one path is optically connected with a synchronous imaging mechanism and a detector mechanism in sequence according to the light emitting direction, and the other path is optically connected with a scanning imaging mechanism, an eyepiece mechanism, and an eyepiece adjustment mechanism in sequence according to the light emitting direction, and the scanning imaging mechanism is also optically connected with an internal fixation mechanism; the light source mechanism is used to provide light sources of different wavelengths; the collimating imaging mechanism The incident light meter is optically connected to the light output side of the light source mechanism, and the collimating imaging mechanism collimates and shapes the light provided by the light source mechanism; the scanning mechanism obtains the light source of the light source mechanism through the optical signal of the collimating imaging mechanism through the scanning imaging mirror assembly in the scanning mechanism and then outputs it, and corrects the optical aberration and enlarges the viewing angle; the eyepiece mechanism is used to receive the optical signal of the scanning mechanism and guide the optical signal into the human eye adjusted by the eyepiece adjustment mechanism; the internal fixation mechanism is used for imaging and guiding the human eye position adjusted by the eyepiece adjustment mechanism; the detector mechanism is used to obtain imaging signals for fundus imaging.

[0006] Specifically, the scanning imaging lens group in the scanning mechanism corrects the spherical aberration, astigmatism, and chromatic aberration of the system to ensure that different wavelengths have high imaging quality and the best imaging working distance is consistent. By changing the shape and spacing of the lens, the trend of light is adjusted to enlarge the viewing angle.

[0007] In a preferred embodiment of the present invention, the light source mechanism includes a mounting seat, on which a single-channel light source group, a PCB support plate, and a four-in-one beam splitter are arranged, a PCB board is arranged on the PCB support plate, the single-channel light source group is optically connected to a collimation imaging mechanism connected to the PCB board through the four-in-one beam splitter, and the light source mechanism includes at least two or more wavelengths.

[0008] Specifically, the light source mechanism can adopt a multi-channel light source in the prior art to achieve rapid switching between different wavelengths at the ns level.

[0009] In a preferred embodiment of the present invention, the eyepiece adjustment mechanism includes an eyepiece positioning seat and a refractive support seat arranged on the shell of the laser ophthalmic diagnostic instrument, the eyepiece is arranged on the eyepiece positioning seat, and the eyepiece is located on one side of the scanning imaging mechanism; the refractive support seat is slidably connected to a guide rail arranged below the scanning optical path support seat through a refractive motor, and the refractive motor is connected to the scanning optical path support seat.

[0010] Specifically, the scanning light path support seat is driven to slide on the guide rail to adjust the distance from the scanning light path support seat to the eyepiece, thereby achieving diopter adjustment.

[0011] In a preferred embodiment of the present invention, the internal fixation mechanism includes an internal fixation display, which is optically connected to the scanning imaging mechanism via an imaging lens assembly, and the image formed on the internal fixation display is used to guide the position of human eyes.

[0012] In a preferred embodiment of the present invention, the synchronous imaging mechanism includes a filter switching seat, on which a plurality of different filters are arranged, and the filter switching seat is slidably arranged in the housing of the laser ophthalmological diagnostic instrument through a slide rail; and the filter switching seat is located between the optical path of the spectroscope and the detector mechanism, and the filter in the optical path between the spectroscope and the detector mechanism is adjusted by displacing the filter switching seat relative to the sampling port of the detector mechanism.

[0013] In a preferred embodiment of the present invention, the synchronous imaging mechanism includes a filter switching seat, on which a plurality of different filters are arranged, and the filter switching seat is rotatably connected to the housing of the laser ophthalmological diagnostic instrument via a rotating shaft; and the filter switching seat is located between the optical path of the spectroscope and the detector mechanism, and the filter in the optical path between the spectroscope and the detector mechanism is adjusted by rotating the filter switching seat relative to the sampling port of the detector mechanism.

[0014] In a preferred embodiment of the present invention, the internal fixation mechanism further comprises an internal fixation lamp and a display screen lamp arranged in the housing.

[0015] Specifically, the collimating mechanism includes a spherical lens, a cylindrical lens, an aspherical mirror, a prism, or a micro-optical device.

[0016] Specifically, the eyepiece mechanism includes a spherical mirror, an aspherical mirror, a double-cemented aspherical mirror, or a free-form mirror.

[0017] Specifically, the scanning imaging mechanism includes a one-dimensional mirror, a MEMS mirror, or a two-dimensional mirror.

[0018] Specifically, the power supply of the light source mechanism is a linear constant current source.

[0019] In a preferred embodiment of the present invention, the refraction is adjusted by moving the collimating mechanism; the collimating mechanism performs a refraction adjustment of ≥±D, wherein D is the refraction.

[0020] Specifically, the different refraction of the human eye causes the conjugate distance of the entire optical system to change, that is, the image of the myopic eye is in front of the retina, and the image of the hyperopic eye is behind the retina. By ensuring the dispersion correction of the system, the axial magnification of the collimator mechanism is reduced and the sensitivity of the refractive adjustment stroke is reduced.

[0021] In a preferred embodiment of the present invention, the single-channel light source group includes single-channel light source one, single-channel light source two, single-channel light source three, and single-channel light source four, which are arranged on a mounting base, and the single-channel light source one, single-channel light source two, single-channel light source three, and single-channel light source four use light sources of different wavelengths.

[0022] In a preferred embodiment of the present invention, a detection method of a high-resolution laser ophthalmological diagnostic instrument system is implemented using a high-resolution laser ophthalmological diagnostic instrument system, comprising the following steps: Step S1, according to the rising edge of the feedback signal of the X-ray galvanometer, the single-channel light source 4 is turned off, and the single-channel light source 1 is turned on to obtain a line of images containing sodium fluorescein angiography; Step S2, according to the falling edge of the high-speed galvanometer feedback signal, the single-channel light source 1 is turned off, and the single-channel light source 4 is turned on to obtain a row of images containing indocyanine green angiography; Step S3, moving the Y galvanometer and repeating steps S1 and S2 until a complete fundus image is obtained; Step S4, performing line coding on the image data and transmitting it to the host computer; Step S5: the host computer divides the image into two images, namely, a sodium fluorescein contrast image and an indocyanine green contrast image, according to the lines, and displays them.

[0023] Specifically, the mechanical switching structure of the filter switching seat of the synchronous imaging mechanism can be, but is not limited to, a pull-out type or a rotation type. Due to the existence of the synchronous imaging mechanism, the optical system of the laser ophthalmological diagnostic instrument can simultaneously present fundus fluorescence imaging patterns of two or more contrast agents. The PCB board includes PCB board 1 and PCB board 2.

[0024] Compared with the prior art, the present invention has the following beneficial effects: The invention discloses a high-resolution laser ophthalmology diagnostic instrument system and a detection method thereof, which can be used for synchronous imaging to obtain imaging images of multiple eye structures.

[0025] Synchronous angiography is an ophthalmic imaging technique used to simultaneously obtain angiographic images of multiple structures of the eye. In order to improve the accuracy and efficiency of disease diagnosis, synchronous angiography is combined with laser diagnosis to simultaneously display the vascular structures of the retinal surface, deep layers, and choroid. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] The present invention is further described below in conjunction with the accompanying drawings and embodiments.

[0027] Figure 1 is a schematic diagram of a high-resolution laser ophthalmological diagnostic instrument system in a preferred embodiment of the present invention; Figure 2 is a mechanical framework diagram of a high-resolution laser ophthalmological diagnostic instrument system in a preferred embodiment of the present invention; Figure 3 is an enlarged mechanical frame diagram of a high-resolution laser ophthalmological diagnostic instrument system in a preferred embodiment of the present invention; Figure 4 It is a schematic diagram of the optical part of a scanning imaging mechanism of a high-resolution laser ophthalmological diagnostic instrument system in a preferred embodiment of the present invention; Figure 5 is a schematic diagram of an eyepiece mechanism of a high-resolution laser ophthalmological diagnostic instrument system in a preferred embodiment of the present invention; Figure 6 It is a schematic diagram of fundus blood flow in a high-resolution laser ophthalmological diagnostic instrument system in a preferred embodiment of the present invention; Figure 7 is a schematic diagram of an eyepiece adjustment mechanism of a high-resolution laser ophthalmological diagnostic instrument system in a preferred embodiment of the present invention; Figure 8 Schematic diagram of an internal fixation mechanism of a high-resolution laser ophthalmological diagnostic instrument system in a preferred embodiment of the present invention; Fig. 9 is a schematic diagram of a detector mechanism of a high-resolution laser ophthalmology diagnostic instrument system in a preferred embodiment of the present invention; Fig.10It is a schematic diagram of the light source mechanism of a high-resolution laser ophthalmological diagnostic instrument system in a preferred embodiment of the present invention; Fig.11 It is a schematic flow chart of the synchronous imaging function of a high-resolution laser ophthalmological diagnostic instrument system in a preferred embodiment of the present invention; Fig.12 It is a schematic diagram of a pull-out filter switching structure of a high-resolution laser ophthalmology diagnostic instrument system in a preferred embodiment of the present invention; Fig.13 It is a schematic diagram of a rotating filter switching structure of a high-resolution laser ophthalmological diagnostic instrument system in a preferred embodiment of the present invention; Fig.14 It is a schematic diagram of a high-resolution laser ophthalmological diagnostic instrument system using a collimation mechanism to adjust the refractive structure in a preferred embodiment of the present invention; Fig.15 It is a schematic diagram of the installation structure of an X-galvanometer and a Y-galvanometer of a high-resolution laser ophthalmology diagnostic instrument system in a preferred embodiment of the present invention; Light source mechanism, 20-collimation imaging mechanism, 201-single channel light source 1, 202-single channel light source 2, 203-single channel light source 3, 204-single channel light source 4, 205-beam splitter 4-in-1, 206-PCB support plate, 207-PCB board 1, 208-PCB board 2, 209-cover plate, 210-optical fiber cable bayonet, 211-power connector 1, 212-connector 2, 30-scanning imaging mechanism, 301-optical part, 4 0-eyepiece mechanism, 401-eyepiece positioning seat, 402-eyepiece, 50-synchronous imaging mechanism, 60-internal fixation mechanism, 601-fixation lamp, 602-display screen lamp, 603-internal fixation axial adjustment shaft, 604-scanning optical path support seat, 70-detector mechanism, 701-rotating filter switching structure, 702-pinhole device, 80-beam splitter, 90-eyepiece adjustment mechanism, 901-X galvanometer, 902-Y galvanometer, 904-top screw. DETAILED DESCRIPTION

[0028] The technical solution of the present invention is described in detail below through the accompanying drawings and specific embodiments. It should be understood that the embodiments of the present invention and the specific features in the embodiments are detailed descriptions of the technical solution of the present invention, rather than limitations on the technical solution of the present invention. The embodiments of the present invention and the technical features in the embodiments may be combined with each other unless there is a conflict.

[0029] The term "and / or" is only a description of the association relationship between related objects, indicating that there can be three relationships. For example, A and / or B can mean: A exists alone, A and B exist at the same time, and B exists alone. In addition, the character " / " generally indicates that the related objects are in an "or" relationship. Embodiment 1

[0030] like Figure 1 , Figure 2 As shown, the present invention discloses a high-resolution laser ophthalmology diagnostic instrument system, which includes: a spectroscope 80, a collimating imaging mechanism 20 is arranged on the light source introduction side of the spectroscope 80, and the light source of the light source mechanism 10 is introduced through the collimating imaging mechanism 20. The detection side of the spectroscope 80 is divided into two paths, one path is optically connected to the synchronous imaging mechanism 50 and the detector mechanism 70 in sequence according to the light emitting direction, and the other path is optically connected to the scanning imaging mechanism 30, the eyepiece mechanism 40, and the eyepiece adjustment mechanism 90 in sequence according to the light emitting direction, and the scanning imaging mechanism 30 is also optically connected to the internal fixation mechanism 60.

[0031] Specifically, the light source mechanism 10 includes a mounting seat, on which a single-channel light source group, a PCB support plate 206, and a four-in-one beam splitter 205 are arranged, a PCB board is arranged on the PCB support plate 206, and the single-channel light source group is optically connected to the collimation imaging mechanism 20 connected to the PCB board through the four-in-one beam splitter 205, and the light source mechanism 10 contains at least two or more wavelengths. The light source mechanism 10 is used to provide light sources of different wavelengths; the PCB board includes a PCB board 1 207 and a PCB board 2 208. Further, the power supply of the light source mechanism 10 is powered by a linear constant current source. The single-channel light source group includes a single-channel light source 1 201, a single-channel light source 2 202, a single-channel light source 3 203, and a single-channel light source 4 204 arranged on the mounting seat, which are used to provide light sources of different wavelengths.

[0032] Specifically, the incident light of the collimating imaging mechanism 20 is optically connected to the light output side of the light source mechanism 10, and the collimating imaging mechanism 20 collimates and shapes the light provided by the light source mechanism 10. Furthermore, the collimating mechanism 20 includes a spherical lens, a cylindrical lens, an aspherical mirror, a prism, or a micro-optical device. When designing the optical system, the sensitivity of the collimating mechanism 20 to the entire system is reduced, and the refraction can be adjusted by moving the collimating mechanism 20; the collimating mechanism 20 can achieve a refraction adjustment of ≥±25D. More specifically, diffractive optical elements (Diffractive Optical Elements), referred to as DOE, also known as binary optical devices, are mainly used for laser beam shaping. Its principle of through-light micro-optical imaging can shape the laser into a specified spot shape and light intensity distribution, such as homogenization, collimation, focusing, forming a specific pattern, etc. The microlens array is an array composed of lenses with a clear aperture and a relief depth of micrometers. Like traditional lenses, its smallest functional unit can also be a spherical lens, aspherical lens, cylindrical lens, prism, etc., and it can also achieve focusing, collimation transformation and other functions at micro-optical angles. Because of its small unit size and high integration, it can form many new optical systems and complete functions that traditional optical components cannot complete.

[0033] Specifically, the scanning mechanism 30 scans and images the acquired optical signal through the scanning imaging mirror assembly in the scanning mechanism 30 and then outputs it, and corrects the optical aberration and enlarges the viewing angle. Further, the scanning imaging mechanism 30 includes a mirror one-dimensional galvanometer, a MEMS galvanometer, or a two-dimensional galvanometer. The optical part 301 in the scanning imaging mechanism 30 is as follows: Figure 4 As shown, it can be composed of a traditional mirror, a one-dimensional galvanometer of a galvanometer group, a MEMS galvanometer, a two-dimensional galvanometer, a DMD, etc.; Specifically, the eyepiece mechanism 40 includes an eyepiece positioning seat 401 disposed on the housing of the laser ophthalmic diagnostic instrument, an eyepiece 402 is disposed on the eyepiece positioning seat 401, and the eyepiece 402 is located between the scanning imaging mechanism 30 and the eyepiece adjustment mechanism 90. The eyepiece mechanism 40 is used to receive the optical signal of the scanning mechanism 30, and guide the optical signal into the human eye adjusted by the eyepiece adjustment mechanism 90. Further, the eyepiece mechanism 40 includes a spherical mirror, an aspherical mirror, a double-glued aspherical mirror, or a free-form mirror. One-dimensional galvanometer, MEMS galvanometer, two-dimensional galvanometer More specifically, the eyepiece mechanism 40 receives the optical signal of the scanning mechanism 30, and guides it into the human eye; Figure 5 The eyepiece mechanism 40 shown can be composed of an eyepiece positioning seat 401; an eyepiece 402 composed of a spherical lens, an aspherical lens, a double-cemented aspherical lens, a free-form surface lens, etc.; wherein the eyepiece mechanism 40 can be switched to adapt to environments with different resolution requirements, and the retinal blood vessels of the fundus can be clearly seen, and the blood flow and cells of the blood vessels of the fundus can also be observed. Figure 6 As shown, the blood flow inside the blood vessel can be clearly observed. Since the eyepiece can be switched, that is, the eyepiece and the overall mechanical structure are not integrated, assembly errors are prone to occur during the assembly of the eyepiece, thereby reducing the system resolution.

[0034] Specifically, the synchronous imaging mechanism 50 includes a filter switching seat, on which a plurality of different filters are arranged, and the filter switching seat is slidably arranged in the housing of the laser ophthalmology diagnostic instrument through a slide rail; and the filter switching seat is located between the optical path of the spectroscope 80 and the detector mechanism 70, and the filter in the optical path between the spectroscope 80 and the detector mechanism 70 is adjusted by displacing the filter switching seat relative to the sampling port of the detector mechanism 70. Furthermore, the spectroscope 80 divides the light into the detector mechanism 70 in proportion through the collimating imaging mechanism 20. In other embodiments, the spectroscope mechanism 80 may use spectroscopes with different splitting ratios, or may use a hollow spectroscope, that is, a hole is dug in the center of the lens, to reduce system stray light and improve imaging resolution.

[0035] Specifically, the internal fixation mechanism 60 includes an internal fixation, that is, an internal fixation display. The internal fixation display is optically connected to the scanning imaging mechanism 30 through an imaging lens assembly, and the image formed on the internal fixation display is used to guide the position of the human eye. The internal fixation mechanism 60 is used for imaging and guiding the position of the human eye adjusted by the eyepiece adjustment mechanism 90. Furthermore, the internal fixation mechanism 60 also includes an internal fixation lamp 601 and a display screen lamp 602 arranged in the shell. More specifically, the internal fixation display / LED lamp is optically connected to the scanning imaging mechanism 30 through an imaging lens assembly, and the rotation of the human eyeball can be guided by changing the position of the internal fixation point; Figure 7 The inner fixation mechanism 60 shown is composed of an inner fixation lamp 601 and a display screen 602. The lamp can be a breathing type to reduce eye fatigue during observation. Specifically, the inner fixation lamp 601 is below the display screen lamp 602, and the inner fixation is installed on the scanning light path support seat 604 through the inner fixation axial adjustment shaft 603. The inner fixation position is fine-tuned by adjusting the inner fixation axial adjustment shaft 603. The inner fixation lamp 601 and the display screen 602 are on the same circuit board and can be selected and used according to needs.

[0036] Specifically, the detector mechanism 70 is used to obtain imaging signals for fundus imaging. Fig. 9 The detector in the detector mechanism 70 shown can be composed of APD [Avalanche Photo Diode, a semiconductor photodetector], PMT [Photomultiplier Tube, a vacuum electronic device], PD [Photo Diode, a semiconductor photodetector], MPPC [Multi-Pixel Photon Counter, a semiconductor photodetector], etc.; a suitable detector is selected according to the actual light sensitivity.

[0037] Specifically, Figure 7 As shown, the eyepiece adjustment mechanism 90 can fine-tune the eyepiece position to align it with the front optical system of the eyepiece to reduce the aberration of the overall system caused by assembly. Embodiment 2

[0038] like Figure 1 , Figure 2As shown, the present invention discloses a high-resolution laser ophthalmology diagnostic instrument system, which includes: a spectroscope 80, a collimating imaging mechanism 20 is arranged on the light source introduction side of the spectroscope 80, and the light source of the light source mechanism 10 is introduced through the collimating imaging mechanism 20. The detection side of the spectroscope 80 is divided into two paths, one path is optically connected to the synchronous imaging mechanism 50 and the detector mechanism 70 in sequence according to the light emitting direction, and the other path is optically connected to the scanning imaging mechanism 30, the eyepiece mechanism 40, and the eyepiece adjustment mechanism 90 in sequence according to the light emitting direction, and the scanning imaging mechanism 30 is also optically connected to the internal fixation mechanism 60.

[0039] Specifically, the light source mechanism 10 includes a mounting seat, on which a single-channel light source group, a PCB support plate 206, and a four-in-one beam splitter 205 are arranged, a PCB board is arranged on the PCB support plate 206, and the single-channel light source group is optically connected to the collimation imaging mechanism 20 connected to the PCB board through the four-in-one beam splitter 205, and the light source mechanism 10 contains at least two or more wavelengths. The light source mechanism 10 is used to provide light sources of different wavelengths; the PCB board includes a PCB board 1 207 and a PCB board 2 208. Further, the power supply of the light source mechanism 10 is powered by a linear constant current source. The single-channel light source group includes a single-channel light source 1 201, a single-channel light source 2 202, a single-channel light source 3 203, and a single-channel light source 4 204 arranged on the mounting seat, which are used to provide light sources of different wavelengths.

[0040] Specifically, the incident light of the collimating imaging mechanism 20 is optically connected to the light output side of the light source mechanism 10, and the collimating imaging mechanism 20 collimates and shapes the light provided by the light source mechanism 10. Furthermore, the collimating mechanism 20 includes a spherical lens, a cylindrical lens, an aspherical mirror, a prism, or a micro-optical device. When designing the optical system, the sensitivity of the collimating mechanism 20 to the entire system is reduced, and the refraction can be adjusted by moving the collimating mechanism 20; the collimating mechanism 20 can achieve a refraction adjustment of ≥±25D. More specifically, diffractive optical elements (Diffractive Optical Elements), referred to as DOE, also known as binary optical devices, are mainly used for laser beam shaping. Its principle of through-light micro-optical imaging can shape the laser into a specified spot shape and light intensity distribution, such as homogenization, collimation, focusing, forming a specific pattern, etc. The microlens array is an array composed of lenses with a clear aperture and a relief depth of micrometers. Like traditional lenses, its smallest functional unit can also be a spherical lens, aspherical lens, cylindrical lens, prism, etc., and it can also achieve focusing, collimation transformation and other functions at micro-optical angles. Because of its small unit size and high integration, it can form many new optical systems and complete functions that traditional optical components cannot complete.

[0041] Specifically, the scanning mechanism 30 scans and images the acquired optical signal through the scanning imaging mirror assembly in the scanning mechanism 30 and then outputs it, and corrects the optical aberration and enlarges the viewing angle. Further, the scanning imaging mechanism 30 includes a mirror one-dimensional galvanometer, a MEMS galvanometer, or a two-dimensional galvanometer. The optical part 301 in the scanning imaging mechanism 30 is as follows: Figure 4 As shown, it can be composed of a traditional mirror, a one-dimensional galvanometer of a galvanometer group, a MEMS galvanometer, a two-dimensional galvanometer, a DMD, etc.; Specifically, the eyepiece mechanism 40 includes an eyepiece positioning seat 401 disposed on the housing of the laser ophthalmic diagnostic instrument, an eyepiece 402 is disposed on the eyepiece positioning seat 401, and the eyepiece 402 is located between the scanning imaging mechanism 30 and the eyepiece adjustment mechanism 90. The eyepiece mechanism 40 is used to receive the optical signal of the scanning mechanism 30, and guide the optical signal into the human eye adjusted by the eyepiece adjustment mechanism 90. Further, the eyepiece mechanism 40 includes a spherical mirror, an aspherical mirror, a double-glued aspherical mirror, or a free-form mirror. One-dimensional galvanometer, MEMS galvanometer, two-dimensional galvanometer More specifically, the eyepiece mechanism 40 receives the optical signal of the scanning mechanism 30, and guides it into the human eye; Figure 5 The eyepiece mechanism 40 shown can be composed of an eyepiece positioning seat 401; an eyepiece 402 composed of a spherical lens, an aspherical lens, a double-cemented aspherical lens, a free-form surface lens, etc.; wherein the eyepiece mechanism 40 can be switched to adapt to environments with different resolution requirements, and the retinal blood vessels of the fundus can be clearly seen, and the blood flow and cells of the blood vessels of the fundus can also be observed. Figure 6 As shown, the blood flow inside the blood vessel can be clearly observed. Since the eyepiece can be switched, that is, the eyepiece and the overall mechanical structure are not integrated, assembly errors are prone to occur during the assembly of the eyepiece, thereby reducing the system resolution.

[0042] Specifically, the synchronous imaging mechanism 50 includes a filter switching seat, on which a plurality of different filters are arranged, and the filter switching seat is rotatably connected to the housing of the laser ophthalmology diagnostic instrument through a rotating shaft; and the filter switching seat is located between the optical path of the spectroscope 80 and the detector mechanism 70, and the filter in the optical path between the spectroscope 80 and the detector mechanism 70 is adjusted by rotating the filter switching seat relative to the sampling port of the detector mechanism 70. Furthermore, the spectroscope 80 divides the light into the detector mechanism 70 in proportion through the collimating imaging mechanism 20. In other embodiments, the spectroscope mechanism 80 may use spectroscopes with different splitting ratios, or may use a hollow spectroscope, that is, a hole is dug in the center of the lens, to reduce system stray light and improve imaging resolution.

[0043] Specifically, the internal fixation mechanism 60 includes an internal fixation display, which is optically connected to the scanning imaging mechanism 30 via an imaging lens assembly, and the image formed on the internal fixation display is used to guide the position of the human eye. The internal fixation mechanism 60 is used to form an image and guide the position of the human eye adjusted by the eyepiece adjustment mechanism 90. Furthermore, the internal fixation mechanism 60 also includes an internal fixation lamp 601 and a display lamp 602 disposed in the shell. More specifically, the internal fixation display / LED lamp is optically connected to the scanning imaging mechanism 30 via an imaging lens assembly, and the rotation of the human eyeball can be guided by changing the position of the internal fixation point; Figure 7 The inner fixation mechanism 60 shown is composed of an inner fixation lamp 601 and a display screen lamp 602. The lamp can be a breathing type to reduce the fatigue of the eyes when observing.

[0044] Specifically, the detector mechanism 70 is used to obtain imaging signals for fundus imaging. Fig. 9 The detector in the detector mechanism 70 shown can be composed of APD, PMT, PD, MPPC, etc.; a suitable detector is selected according to the actual light sensitivity.

[0045] Specifically, Figure 7 As shown, the eyepiece adjustment mechanism 90 can fine-tune the eyepiece position to align it with the front optical system of the eyepiece to reduce the aberration of the overall system caused by assembly. Embodiment 3

[0046] On the basis of the first or second embodiment, the mechanical switching structure of the filter switching seat of the synchronous imaging mechanism 50 can be but not limited to the pull-out type and the rotating type. Due to the existence of the synchronous imaging mechanism 50, the optical system of the laser ophthalmological diagnostic instrument can simultaneously present the fundus fluorescence imaging patterns of two or more contrast agents. The pinhole device 702 of the detector mechanism 70 is fixed on the scanning light path support seat 604 through the pinhole support adjustment seat, and the mechanical switching structure of the filter switching seat of the synchronous imaging mechanism 50 adopts a rotating filter switching structure 701. The scanning light path support seat 604 is the main body of the entire light path, and most of the lens components are installed and fixed on the scanning light path support seat 604. The X galvanometer 901 and the Y galvanometer 902 in the light path are both installed on the scanning light path support seat 604 and fixed by the top screw 906. The galvanometer chamber cover is a reserved galvanometer inspection window, which plays a role in inspection and sound insulation. The X galvanometer 901 is used to collect fundus images in the X direction, and the Y galvanometer 902 is used to collect fundus images in the Y direction. Embodiment 4

[0047] On the basis of Example 1 or Example 2, Figure 1 , Figure 2 , Figure 3As shown, a detection method of a high-resolution laser ophthalmology diagnostic instrument system is implemented using a high-resolution laser ophthalmology diagnostic instrument system, comprising the following steps: Step S1, according to the rising edge of the high-speed galvanometer feedback signal, the single-channel light source 204 is turned off, and the single-channel light source 201 is turned on to obtain a line of images containing sodium fluorescein angiography; Step S2, according to the falling edge of the high-speed galvanometer feedback signal, the single-channel light source 1 201 is turned off, and the single-channel light source 4 204 is turned on to obtain a line of images containing sodium fluorescein angiography; Step S3, moving the low-speed galvanometer and repeating steps S1 and S2 until a complete fundus image is obtained; Step S4, line-encoding the image data and transmitting it to the host computer.

[0048] The optical signal is first converted into an electrical signal by the detection mechanism 70, and the electrical signal is converted into an image grayscale signal by the AD chip in the internal circuit of the device. Different light source channels correspond to different images: the single-channel light source 1 201 corresponds to the "fluorescein sodium angiography image", and the single-channel light source 4 204 corresponds to the "indocyanine green angiography image". Different channels correspond to different fluorescent images.

[0049] Step S5: the host computer divides the image into two images, namely, a sodium fluorescein contrast image and an indocyanine green contrast image, according to the lines, and displays them.

[0050] Specifically, after the fundus is combined with the contrast agent, different fluorescence can be stimulated by the light source; the synchronous imaging function is mainly achieved by quickly switching the wavelength of the light source. Different wavelengths are filtered by different bandpass filters, and the fundus fluorescence information under the corresponding contrast agent can be obtained.

[0051] Specifically, for different reflective imaging modes and fluorescent imaging modes, it is necessary to cope with the scenarios where no filter is required or different filters are switched. In this embodiment, Fig.11 and 12 As shown, there are pull-out and rotation filter switching structures respectively.

[0052] Specifically, when the acquisition step of step S4 is used, the corresponding filter is that which can excite the fundus laser through blue light and near-infrared, and the device switches to the corresponding gear; when we normally use blue / green / red / infrared and other wavelengths of light to scan the fundus and take a (non-fluorescent) image of the light reflected back from the fundus, it is not necessary to pass through the filter, and the device switches to a gear without a filter; there are other cases such as autofluorescence, and filters of other gears of the device are used. Furthermore, the single-channel light source 1 201 corresponds to the "sodium fluorescein angiography image", and the single-channel light source 4 204 corresponds to the "indocyanine green angiography image". Different channels correspond to different fluorescent images. The single-channel light source 1 201 is blue light, and the single-channel light source 4 204 is near-infrared light. Embodiment 5

[0053] Based on the first embodiment, Fig.14 As shown, the conventional method of adjusting the refraction is to move the eyepiece mechanism 40. Since the working distance between the laser diagnostic instrument and the human eye is often short, the refraction is generally adjusted by moving all the systems in front of the eyepiece, that is, changing the relative distance to the eyepiece. This scheme requires the entire system to be moved during adjustment, which is complicated and bulky. The present invention adjusts the refraction by adjusting the collimating mechanism 20; the refraction adjustment range can reach more than ±25D, and the complexity and stroke of the refraction adjustment are greatly reduced.

[0054] Specifically, different refraction of human eyes causes the conjugate distance of the entire optical system to change, that is, myopia is imaged in front of the retina, and hyperopia is imaged behind the retina. Based on the Gaussian imaging principle, the refraction motor 802 drives the refraction drive seat 404 to move and adjust the refraction assembly. When myopia occurs, the distance to the eyepiece 402 is shortened; when hyperopia occurs, the distance to the eyepiece 402 is extended.

[0055] Working principle: A high-resolution laser ophthalmological diagnostic instrument optical system. The laser beam relies on an oscillating mirror to periodically deflect to scan a two-dimensional retinal image. The intensity of the reflected light at each point or the light emitted by the laser-excited dye will be measured by a sensitive detector, which has a high resolution and can not only see the retinal blood vessels of the fundus, but also observe the blood flow and cells of the fundus blood vessels. At the same time, when dealing with human eyes with different refractive powers, the optical system disclosed in the patent of the present invention adjusts the refraction through a collimation mechanism, which greatly reduces the complexity of the refraction adjustment compared with the traditional refraction adjustment method. The light source mechanism of the patent of the present invention is powered by a fast-response linear constant current source, has a stable output power, and has fast switching between different wavelengths at the ns level; the synchronous imaging mechanism provides different filters to filter the excited fundus fluorescence, and finally can simultaneously present the fundus fluorescence imaging patterns of two or more contrast agents.

[0056] Based on the ideal embodiment of the present invention, through the above description, relevant personnel can make various changes and modifications without departing from the technical concept of the present invention. The technical scope of the present invention is not limited to the content in the specification, and the technical scope must be determined according to the scope of the claims.

Claims

1. A high-resolution laser ophthalmological diagnostic instrument system, characterized in that: The laser ophthalmological diagnostic instrument comprises: a spectroscope (80), wherein a collimating imaging mechanism (20) is provided on a light source introduction side of the spectroscope (80), and a light source of a light source mechanism (10) is introduced through the collimating imaging mechanism (20); the detection side of the spectroscope (80) is divided into two paths, one path being optically connected in sequence to a synchronous imaging mechanism (50) and a detector mechanism (70) in accordance with a light emitting direction, and the other path being optically connected in sequence to a scanning imaging mechanism (30), an eyepiece mechanism (40), and an eyepiece adjustment mechanism (90) in accordance with a light emitting direction, and the scanning imaging mechanism (30) is also optically connected to an internal fixation mechanism (60); The light source mechanism (10) is used to provide light sources with different wavelengths; The light incident side of the collimating imaging mechanism (20) is optically connected to the light emitting side of the light source mechanism (10), and the collimating imaging mechanism (20) collimates and shapes the light provided by the light source mechanism (10); The scanning mechanism (30) obtains the light source of the light source mechanism (10) through the optical signal of the collimating imaging mechanism (20), and outputs the scanned image through the scanning imaging mirror assembly in the scanning mechanism (30), and corrects the optical aberration and enlarges the viewing angle; The eyepiece mechanism (40) is used to receive the optical signal from the scanning mechanism (30) and guide the optical signal into the human eye adjusted by the eyepiece adjustment mechanism (90); The inner fixation mechanism (60) is used for imaging and guiding the eyepiece adjustment mechanism (90) to adjust the position of the human eye; The detector mechanism (70) is used to obtain imaging signals for fundus imaging.

2. The high-resolution laser ophthalmological diagnostic instrument system according to claim 1, characterized in that: The light source mechanism (10) comprises a mounting seat, on which a single-channel light source group, a PCB support plate (206), and a four-in-one beam splitter (205) are arranged, a PCB board is arranged on the PCB support plate (206), the single-channel light source group is optically connected to a collimation imaging mechanism (20) connected to the PCB board via the four-in-one beam splitter (205), and the light source mechanism (10) comprises at least two or more wavelengths.

3. The high-resolution laser ophthalmological diagnostic instrument system according to claim 2, characterized in that: The eyepiece adjustment mechanism (90) comprises an eyepiece positioning seat (401) and a refractive support seat (404) arranged on the housing of the laser ophthalmological diagnostic instrument; an eyepiece (402) is arranged on the eyepiece positioning seat (401), and the eyepiece (402) is located on one side of the scanning imaging mechanism (30); the refractive support seat (404) is slidably connected to a guide rail (801) arranged below the scanning light path support seat (604) via a refractive motor (802), and the refractive motor (802) is connected to the scanning light path support seat (604).

4. The high-resolution laser ophthalmological diagnostic instrument system according to claim 3, characterized in that: The internal fixation mechanism (60) comprises an internal fixation display, the internal fixation display is optically connected to the scanning imaging mechanism (30) via an imaging lens assembly, and the image formed on the internal fixation display is used to guide the position of human eyes.

5. The high-resolution laser ophthalmological diagnostic instrument system according to claim 4, characterized in that: The synchronous imaging mechanism (50) comprises a filter switching seat, on which a plurality of different filters are arranged, and the filter switching seat is slidably arranged in a housing of the laser ophthalmology diagnostic instrument via a slide rail; and the filter switching seat is located between the optical path of the beam splitter (80) and the detector mechanism (70), and the filter in the optical path between the beam splitter (80) and the detector mechanism (70) is adjusted by displacing the filter switching seat relative to the sampling port of the detector mechanism (70).

6. The high-resolution laser ophthalmological diagnostic instrument system according to claim 4, characterized in that: The synchronous imaging mechanism (50) comprises a filter switching seat, on which a plurality of different filters are arranged, and the filter switching seat is rotatably connected to a housing of the laser ophthalmology diagnostic instrument via a rotating shaft; and the filter switching seat is located between the optical path of the beam splitter (80) and the detector mechanism (70), and the filter in the optical path between the beam splitter (80) and the detector mechanism (70) is adjusted by rotating the filter switching seat relative to the sampling port of the detector mechanism (70).

7. The high-resolution laser ophthalmological diagnostic instrument system according to claim 5 or 6, characterized in that: The internal fixation mechanism (60) further comprises an internal fixation lamp (601) and a display screen lamp (602) arranged in the housing.

8. The high-resolution laser ophthalmological diagnostic instrument system according to claim 1, characterized in that: The refraction is adjusted by moving the collimating mechanism (20); the collimating mechanism (20) performs a refraction adjustment of ≥±25D, wherein D is the refraction.

9. The high-resolution laser ophthalmological diagnostic instrument system according to claim 5 or 6, characterized in that: The single-channel light source group comprises a single-channel light source one (201), a single-channel light source two (202), a single-channel light source three (203), and a single-channel light source four (204) which are arranged on a mounting seat, and the single-channel light source one (201), the single-channel light source two (202), the single-channel light source three (203), and the single-channel light source four (204) use light sources of different wavelengths.

10. A detection method for a high-resolution laser ophthalmological diagnostic instrument system, characterized in that: The high-resolution laser ophthalmological diagnostic instrument system according to claim 9 is implemented, comprising the following steps: Step S1, according to the rising edge of the feedback signal of the X-ray galvanometer (901), the single-channel light source four (204) is turned off, and the single-channel light source one (201) is turned on to obtain a line of images containing sodium fluorescein angiography; Step S2, according to the falling edge of the high-speed galvanometer feedback signal, the single-channel light source 1 (201) is turned off, and the single-channel light source 4 (204) is turned on to obtain a line of image containing indocyanine green angiography; Step S3, moving the Y galvanometer (902) and repeating steps S1 and S2 until a complete fundus image is obtained; Step S4, performing line coding on the image data and transmitting it to the host computer; In step S5, the host computer divides the image into two images, namely, a sodium fluorescein contrast image and an indocyanine green contrast image, and displays them row by row.

Images