Biological sensing device starting method

Abstract

The invention discloses a method for starting a biological sensing device. The biological sensing device comprises a sensor module and an electronic signal sensor. The sensor module comprises a biological sensor and a sensor fixing seat. The sensor fixing seat comprises an electric connection unit, and the electric connection unit comprises at least one conductive part electrically connected to the biological sensor. The conductive piece is conductive rubber with a layered structure and is formed by alternately stacking a plurality of insulating layers and a plurality of conductive layers along a first axis. The electronic signal sensor is combined with the sensor module along a second axis direction and comprises a circuit signal unit and a battery, wherein the circuit signal unit is used for being electrically connected with the conductive piece. The circuit signal unit is provided with two electrical contacts, the electrical contacts form a switch, and when the electronic signal sensor is combined with the sensor module, the battery supplies power to the biological sensor, so that power consumption of the battery during storage is avoided.

Description

[0001] This application is a divisional application of application number 202010434400.9, filed on May 21, 2020, and entitled “Biosensing device and method for starting a biosensing device”. Technical Field

[0002] The present invention relates to a sensing device, and in particular to a method for starting a biological sensing device. Background Art

[0003] See also Figures 1 to 3 A conventional sensing device 1, as described in U.S. Pat. No. 7,899,511B2, comprises a sheet of adhesive 11 for being attached to the epidermis, a base 12 attached to the sheet of adhesive 11, a mounting base 13 disposed in the base 12, a sensor 14 mounted on the mounting base 13, and an electronic device 15 disposed on the base 12 and connected to the sensor 14.

[0004] The installation method of the sensing device 1 is to first stick the base 12 provided with the sheet adhesive 11 to the body surface, and then install the sensor 14 combined with the mounting base 13 on the base 12 by an implanter (not shown) (see Figure 2 ), finally, the mounting base 13 is rotated to bend a signal output section 141 of the sensor 14 (see Figure 3 ) so that the sensor 14 is electrically connected to the electronic device 15. Another installation method is to bend the sensor 14 to a predetermined angle and then install it through the implanter.

[0005] Because the sensor 14 can only be connected to the electronic device 15 after being bent, so that the electronic device 15 can read the signal, but this method requires bending the sensor 14 to the required angle, which will increase the stress of the sensor 14 at the bend and easily cause damage. Therefore, this existing design has a higher risk of breaking the sensor 14 when implanting or removing the sensor 14, so there is a need for improvement to improve the process yield. In addition, the internal circuit of the electronic device 15 is in a closed circuit state, that is, regardless of whether it is electrically connected to the sensor 14, the battery will continue to be powered by the internal circuit. Therefore, even if the sensor 14 is not used by the user, it will still consume the power of the battery and reduce the battery life. Summary of the invention

[0006] An object of the present invention is to provide a method for activating a biosensing device that makes the sensor less prone to damage, has excellent electrical conductivity, and can increase the battery life.

[0007] The startup method of the present invention installs the biosensor and the conductive element to the sensor fixing seat to form a sensor module, wherein the conductive element is electrically connected to the biosensor.

[0008] The sensor module is combined with the implant device and with the guide needle.

[0009] The electronic signal sensor is combined with the implant device, and two electrical contacts of the electronic signal sensor form an open circuit state.

[0010] The implant device is placed on the skin surface, and pressure is applied to make the electronic signal sensor adhere to the skin surface.

[0011] The sensor module is coupled to the base of the electronic signal sensor, and the sensing segment portion of the biosensor passes through the base of the electronic signal sensor.

[0012] The sensor module is pushed to the start position by the implant device, and the conductive element is caused to contact with the electrical contact of the electronic signal sensor.

[0013] The battery of the electronic signal sensor is activated to provide power to the sensor module to perform the detection function of the biological sensing device.

[0014] In the startup method of the present invention, when the electrical contact on the electronic signal sensor is in the open circuit state, the battery is in a completely power-off state.

[0015] The startup method of the present invention installs the biosensor and the conductive member to the sensor fixing seat to form the sensor module. The conductive member is a layered structure composed of multiple conductive layers and multiple insulating layers stacked alternately and stacked along a first axis.

[0016] The activation method of the present invention combines the electronic signal sensor with the implant device along a second axis direction, and the second axis direction is not parallel to the first axis direction.

[0017] In the startup method described in the present invention, the first axis and the second axis are located in the same plane and have an angle between them, and the angle remains substantially unchanged before and after the sensing section of the biosensor passes through the base of the electronic signal sensor.

[0018] In the startup method described in the present invention, the number of the conductive members is two, the biosensor has a working electrode and a counter electrode, the two conductive members are electrically connected to the working electrode and the counter electrode respectively, and the electrical contacts are electrically connected to at least one conductive layer of one of the conductive members.

[0019] In the activation method of the present invention, the sensor fixing seat has a fixing groove for fixing the conductive member and the biosensor, and the conductive member is squeezed by the groove wall of the fixing groove of the sensor fixing seat to further tightly engage with the biosensor.

[0020] The beneficial effect of the present invention is that before the biosensor device is used, the sensor module and the electronic signal sensor are separately arranged, and the electrical contacts of the electronic signal sensor are in an open circuit state. When the biosensor device is to be used, the sensor module and the electronic signal sensor are combined to allow the battery to supply power to the biosensor, thereby avoiding power consumption of the battery during storage, so that the battery power can maintain normal operation during the use of the biosensor. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Other features and effects of the present invention will be clearly presented in the embodiments with reference to the accompanying drawings, in which:

[0022] Figure 1 is a three-dimensional exploded diagram illustrating the existing sensing device;

[0023] Figure 2 is a side cross-sectional view illustrating a state where the mounting base of the conventional sensing device is mounted in front of the base;

[0024] Figure 3 is a side cross-sectional view illustrating that the mounting base of the prior art sensing device is mounted on the base, and the sensor is bent to be connected to the base;

[0025] Figure 4 is a perspective exploded view illustrating an embodiment of the biosensing device of the present invention;

[0026] Figure 5 is a perspective exploded view illustrating that the sensor holder in the embodiment has not yet been combined with the base of the electronic signal sensor;

[0027] Figure 6 is a perspective exploded view showing that the sensor module has not yet been combined with the base;

[0028] Figure 7 is a perspective view illustrating the sensor holder in the embodiment coupled to the base of the electronic signal sensor;

[0029] Figure 8 is a perspective view illustrating two conductive members in the embodiment described;

[0030] Fig. 9 It's a piece along Figure 7 A cross-sectional view taken along line IX-IX;

[0031] Fig.10 is a cross-sectional view of the embodiment, wherein the sensor holder has not yet been combined with the electronic signal sensor;

[0032] Fig.11 is a block diagram illustrating a sensing unit of the embodiment;

[0033] Fig.12 is a perspective exploded view illustrating the biosensor of the embodiment;

[0034] Fig.13 is a front view illustrating the biosensor of the embodiment;

[0035] Fig.14 is a front view illustrating a variation of the biosensor of the embodiment, wherein the sensing section and the signal output section of the biosensor are provided with an angle of 135 degrees;

[0036] Fig.15 It is a picture similar to Fig.14 A front view of the present invention, wherein the sensing section and the signal output section are provided with an angle of 45 degrees;

[0037] Fig.16 is a front view illustrating that the signal output section in the embodiment is a pentagon;

[0038] Fig.17 is a front view, illustrating that the signal output section in the embodiment is a rectangle;

[0039] Fig.18 is a front view illustrating another aspect of the biosensor in the embodiment;

[0040] Fig.19 is a partial cross-sectional schematic diagram illustrating that the biosensor in the embodiment is installed via an implant device;

[0041] Fig. 20 is a circuit diagram of the embodiment;

[0042] Fig.21 It is a picture similar to Fig. 20 , but the embodiment only has a conductive element, and the two electrical contacts in the embodiment are connected to different conductive layers of the conductive element;

[0043] Fig. 22 It is a picture similar to Fig.21 , but the electrical contacts are electrically connected to the same conductive layer of the conductive member; and

[0044] Fig.23is a startup flow chart of the biosensor measurement in the embodiment. DETAILED DESCRIPTION

[0045] See also Figures 4 to 7 , the embodiment of the biosensing device of the present invention is suitable for passing through a guide needle 91 (see Fig.19 In this embodiment, the biosensor device is used to measure the blood sugar level of a human body, and the biosensor device includes an electronic signal sensor 2, a sensor fixing seat 3, and a biosensor 4.

[0046] See also Figure 6 , Figure 8 and Fig. 9 The electronic signal sensor 2 includes a base 21, a circuit board 22 arranged on the base 21, a sensor unit 23 arranged on the circuit board 22, a battery 24 arranged on the circuit board 22 and supplying power to the sensor unit 23, and a circuit signal unit 25 arranged on the circuit board 22.

[0047] The base 21 is suitable for being attached to the surface of a biological body, and has a receiving groove 211 , two buckling members 212 , and two springs 213 .

[0048] Each of the locking members 212 can partially protrude out of the receiving groove 211 of the base 21 , and each of the locking members 212 is elastically pressed against by a corresponding spring 213 for pushing the locking member 212 toward a locking position.

[0049] The circuit board 22 is disposed in the base 21 and has a through hole 221 corresponding to the receiving groove 211 .

[0050] See Figure 6 and Fig.11 The sensor unit 23 is disposed on the circuit board 22 and has a signal amplifier 231, an analog / digital signal converter 232, a processor 233, and a transmitter 234. The sensor unit 23 is an existing object, and a person skilled in the art can adjust its internal configuration as needed, which is not limited to the one disclosed in the present invention.

[0051] The circuit signal unit 25 has two electrical contacts 251 spaced apart from each other on the circuit board 22. The electrical contacts 251 form a switch, wherein one of the electrical contacts 251 is electrically connected to the battery 24, and the other electrical contact 251 is usually maintained at a ground potential or a zero potential. Since the electrical contacts 251 are not conductive to each other, the switch is usually in an open circuit disconnected state, so that the battery 24 is completely powered off, i.e., in a zero current state; and when the electrical contact 251 is conductive to form a closed circuit state, the battery 24 will be conductive and provide electrical energy for power supply.

[0052] See also Figure 5 , Figure 6 and Fig. 9 The sensor holder 3 is mounted on the base 21 of the electronic signal sensor 2 and is fixed in the receiving groove 211. The sensor holder 3 has a fixing groove 31, two grooves 32 corresponding to the buckle 212, and an electrical connection unit 33 arranged in the fixing groove 31. The fixing groove 31 has a card slot portion 311 for fixing the electrical connection unit 33, and a sensor slot portion 312. The sensor slot portion 312 corresponds to the through hole 221 of the circuit board 22 and is used to place the part of the biosensor 4.

[0053] The electrical connection unit 33 together with the sensor holder 3 is detachably electrically connected to the circuit board 22 , and has two conductive members 331 spaced apart and electrically connected to the electrical contacts 251 , respectively.

[0054] Each conductive member 331 is composed of multiple layers of electrical insulating rubber and multiple layers of conductive rubber alternately stacked. The conductive member is a layered structure, and the stacking direction of the layered structure extends along a first axis L1. The conductive rubber is a synthetic rubber compounded by conductive powder such as conductive carbon black and silver powder, and presents a black and white zebra stripe with the insulating rubber, such as Figure 8 shown.

[0055] Each conductive member 331 is in the shape of a zebra stripe block. The conductive member 331 is generally in the shape of a hexahedron and has four electrically conductive surfaces and two non-conductive surfaces perpendicular to the first axis L1. As described above, the conductive member is composed of a plurality of insulating layers 331a and a plurality of conductive layers 331b stacked alternately. The electrically conductive surfaces are arranged perpendicularly to the conductive layers 331b. Therefore, the four electrically conductive surfaces of the conductive rubber can be connected to each other through the conductive layers 331b. The conductive surface 333 is used to electrically connect to the biosensor 4, and the second conductive surface 334 is used to electrically connect to the circuit board 22. The first conductive surface 333 and the second conductive surface 334 are adjacent to each other. In the preferred embodiment, the angle between the first conductive surface 333 and the second conductive surface 334 is approximately 90 degrees. Thus, the biosensor 4 and the circuit board 22 are arranged perpendicular to each other, so that the electrodes on the biosensor 4 can be electrically connected to the circuit board 22 through the conductive member 331, so that the electrical signal generated by the biosensor 4 can be transmitted to the circuit board 22 through each conductive member 331, and the biosensor 4 can achieve the purpose of signal transmission without bending, thereby increasing the stability of signal transmission.

[0056] When the sensor holder 3 is coupled to the base 21 of the electronic signal sensor 2 (eg Fig. 9 ), the sensor fixing seat 3 will push the latch 212 to make it retreat to the groove 211 of the base 21, and when the sensor fixing seat 3 is pushed to the bottom of the groove 211, and the latch 212 corresponds to the groove 32 of the sensor fixing seat 3, the latch 212 is reset to the latching position by the pushing of the spring 213 so that the latch 212 and the groove 32 are correspondingly engaged, and the latch 212 is locked to the sensor fixing seat 3, so that the sensor fixing seat 3 can be maintained in a position that is tightly fitted with the circuit board 22.

[0057] Cooperate Figure 5 and Fig.10 The biosensor 4 is installed in the sensor slot 312 of the sensor holder 3 and is electrically connected to the electronic signal sensor 2, and is clamped and fixed by the conductive member 331. The biosensor 4 is used to be implanted in a living body to detect physiological signals in the living body and output electrical signals to the electronic signal sensor 2 accordingly. Therefore, according to its function, the biosensor 4 can be defined and distinguished into a sensing section 401 and a signal output section 402, and the two sections are located in the same plane, so as to Figure 13 to Figure 18A dotted chain line L is used as the boundary, the part below the dotted chain line L is the sensing section 401, and the part above the dotted chain line L is the signal output section 402. The sensing section 401 passes through the through hole 221 of the circuit board 22, and at least a part of the sensing section (401) is used to be implanted in a biological body, such as a human body, and extends along a second axis L2. At least a part of the signal output section 402 is used to be electrically connected to the electronic signal sensor 2, which is arranged between the conductive members 331 and extends along the first axis L1. The second axis L2 is not parallel to the first axis L1 and has an angle θ between them on the same plane. When the angle θ is lower than 4 degrees or higher than 176 degrees, the biosensor 4 will not be convenient to be implanted on the body surface, so preferably, the angle θ is between 4 and 176 degrees, and more preferably, the angle θ is between 45 and 135 degrees. In this embodiment, the angle θ is 90 degrees. See. Fig.12 and Fig.13 , the biosensor 4 measures physiological signals through electrodes and an analytical sensing layer thereon. The biosensor 4 is in the form of a sheet, and in one embodiment, the sensor has a substrate 41, a working electrode 42, and a counter electrode 43. The thickness of the substrate 41 is between 0.05 mm and 0.5 mm. The working electrode 42 and the counter electrode 43 are both arranged on the substrate 41, and are respectively on two opposite sides of the substrate 41, and extend from the sensing section 401 to the signal output section 402. Thus, the signal measured from the sensing section 401 can be transmitted to the signal output section 402 and transmitted to the electronic signal sensor 2 in the form of the electrical signal. The working electrode 42 can be selected from any one of platinum, platinum, gold, chromium, titanium, tungsten, rhodium, iridium, palladium, and graphite, or an alloy thereof. In this embodiment, the counter electrode 43 can be selected from platinum, platinum, gold, chromium, titanium, tungsten, rhodium, iridium, palladium, silver, silver / silver chloride, graphite or alloys thereof, preferably silver / silver chloride.

[0058] It is worth noting that, in order to meet the needs of users, the angle θ of the biosensor 4 on the same plane can be adjusted between 4 degrees and 135 degrees. In another variation of this embodiment, the angle θ is 135 degrees (see Fig.14 ), which can be implanted manually by oblique insertion into the organism. In another variation, the angle θ is 45 degrees (see Fig.15 ), the implantation method can also be carried out manually. In this way, the biosensor 4 can be installed at a suitable angle according to the needs of use. The surface area of ​​the signal output section 402 is larger than the surface area of ​​the sensing section 401, and can have different structural designs, such as L-shaped (see Fig.13), polygon (see Fig.16 ), or a rectangular ( Fig.17 ), and its shape is not limited, as long as it can be stably electrically connected to the conductive member 331 of the electronic signal sensor 2. In this embodiment, the length of the sensing segment 401 of the biosensor 4 along the second axis L2 is between 3 mm and 20 mm, preferably between 5 mm and 7 mm, and the width is between 0.3 mm and 1.0 mm, preferably between 0.3 mm and 0.6 mm.

[0059] In another variation of this embodiment, the biosensor 4 further has a through hole 44 (see Fig.18 The through hole 44 penetrates the working electrode 42, the substrate 41 and the counter electrode 43 to provide a channel for blood to flow between the working electrode 42 and the counter electrode 43, thereby improving the conduction efficiency and reducing the resistance. In addition, the setting of the through hole 44 can also be used to increase the surface area for the reagent (such as the aforementioned analytical sensing layer) to adhere to, so as to increase the stability of the reagent coating.

[0060] In another variation of the present embodiment, the biosensor 4 further has an insulating layer (not shown) stacked on the working electrode 42 or the counter electrode 43, and a reference electrode is disposed on the insulating layer to form a sensor with three electrodes to improve the accuracy of sensing the analyte. The present invention can also add other electrode arrangements or change the orientation of the electrodes on the planar substrate and other different electrode configuration combinations.

[0061] One of the manufacturing methods of this embodiment is to first take a substrate and plate the conductive material required to form the working electrode 42 on it, and then coat the silver / silver chloride layer on the other side and dry it to form the material required for the counter electrode 43. Then, according to the structural shape of the sensor, the portion extending from the periphery to the inside of the sensor shape is removed by laser to form the working electrode 42, and the portion extending from the periphery to the inside of the sensor shape is removed by laser on the other side coated with the silver / silver chloride layer to form the counter electrode 43, and then the plate is cut according to the shape of the sensor to form the semi-finished product of the biosensor 4. In this way, the cutter will not cut the working electrode 42 and the counter electrode 43, thereby preventing the electrodes from deforming. Finally, the analytical sensing layer is covered on the surface of the working electrode 42, and the biosensor 4 is completed. The above manufacturing method is only to introduce that this embodiment can be made in other ways according to the above by a person of ordinary knowledge, so the manufacturing method of this embodiment is not limited to the above method.

[0062] The analytical sensing layer is a mixture of glucose oxidase and a water-soluble cross-linker, wherein the oxidase is used to react with glucose to produce hydrogen peroxide, and then the working electrode 42 will measure the electrical signal corresponding to hydrogen peroxide, and this electrical signal can reflect the amount of glucose in the blood. The water-soluble cross-linker can form a larger group of oxidase to prevent the oxidase from detaching from the electrode of the biosensor 4, and can also selectively allow smaller molecules to pass through. The water-soluble cross-linker can be disuccinimidyl suberate or glutaraldehyde.

[0063] It is worth mentioning that an analyte regulating layer can be coated on the analytical sensing layer. Because the analyte regulating layer is a porous layer, the amount of small molecules (such as glucose) entering can be controlled to adjust the number of small molecules reacting with the analytical sensing layer. The analyte regulating layer can be composed of a glucose-permeable polymer, such as nafion, polyurethane, or polycarbonate. Among them, because the nafion film has negatively charged groups, it is difficult for negatively charged substances in the body to pass through the nafion film, thereby eliminating the interference of negatively charged substances (such as negatively charged drugs).

[0064] See also Figure 5 , Figure 7 and Fig.19 During installation, the base 21 of the electronic signal sensor 2 is first installed on the body surface of the organism through an adhesive patch, and then the sensor fixing seat 3 provided with the conductive member 331 is combined with the guide needle 91 of an implantation device 90, wherein the conductive member 331 is provided on both sides of the biosensor 4. Finally, the guide needle 91 and the sensor fixing seat 3 are aligned with the groove 211 of the base 21, and the implantation device 90 is started to place the sensor fixing seat 3, the conductive member 331 and the guide needle 91 into the groove 211 together, and the sensing segment 401 of the biosensor 4 is implanted into the organism through the guidance of the guide needle 91, and then the guide needle 91 is pulled back and retracted by the implantation device 90 to implant at least a part of the sensing segment 401 in the epidermis of the organism, and thus the installation is completed.

[0065] It is worth mentioning that the installation can also be performed manually. The steps can be that after the electronic signal sensor 2 is installed on the body surface of the organism, the sensor holder 3 provided with the biosensor 4 and the conductive member 331 is combined with the biosensor 4 to the guide needle 91 in a handheld manner, and the guide needle 91 is aligned with the through hole 221 of the circuit board 22, and the guide needle 91 is inserted into the organism by applying force to guide at least a part of the sensing section 401 to be implanted in the body, and at the same time, the sensor holder 3 is installed in the receiving groove 211, and then the guide needle 91 is pulled out to complete the installation. In this way, the installation can also be completed.

[0066] Because an angle has been prefabricated between the sensing section 401 and the signal output section 402 of the biosensor 4, the angle θ remains substantially unchanged before and after the biosensor 4 is implanted into the organism. That is, after being implanted into the organism, the biosensor 4 will not be bent or deformed to affect the electrical connection with the electronic signal sensor 2, thereby preventing damage.

[0067] The biosensor 4 and the conductive member 331 are mounted on the sensor holder 3 to form a sensor module 100. The fixing groove 31 of the sensor holder 3 accommodates the biosensor 4 and the conductive member 331, and the signal output section 402 of the biosensor 4 is clamped by the conductive member 331 and fixed in the fixing groove 31.

[0068] The present invention mainly clamps and fixes the biosensor 4 by virtue of the elasticity of each conductive member 331. For example, the spacing between the conductive members 331 is usually slightly smaller than the thickness of the biosensor 4. Each conductive member 331 can be pressed against the biosensor 4 through the groove wall of the fixing groove 31 of the sensor fixing seat 3, so that the biosensor 4 can be firmly fixed to the sensor fixing seat 3 by the clamping of the conductive members 331. In addition, the bottom end of the conductive member 331 usually slightly protrudes from the bottom end of the signal output section 402 of the biosensor 4 and the bottom of the sensor fixing seat 3. By pushing against the sensor fixing seat 3, the conductive members 331 can be closely fitted with the electrical contacts 251 on the circuit board 22, respectively, to achieve stable electrical conduction.

[0069] The circuit diagram of this embodiment is as follows Fig. 20 Please refer to the following description Figure 8 , Fig. 9 and Fig.10The electrical contact 251 is electrically connected to the biosensor 4 via the corresponding conductive member 331. It is worth mentioning that because the conductive member 331 is a layered structure in which multiple conductive layers 331b and insulating layers 331a are alternately stacked, and each conductive layer 331b is separated by an insulating layer 331a, the conductive layers 331b are not conductive to each other. When the sensor module 100 is electrically connected to the electrical contact 251, the electrical contact 251 will form a path through the electrode on the signal output segment 402 of the biosensor 4, allowing the battery 24 to supply power. In the preferred embodiment, when the electrical contact 251 of the circuit signal unit 25 forms a path, the battery 24 can provide power to the sensor module 100 to perform the detection function of the biosensor device. At the same time, the battery 24 also provides power to the sensor unit 23 of the electronic signal sensor 2, so that the sensor unit 23 can receive the physiological signal measured by the biosensor 4 and transmit the physiological signal to a receiving device 92.

[0070] It is worth noting that, in this embodiment, the number of the conductive members 331 is two. In other variations of this embodiment, the number of the conductive member 331 may also be one. The installation method is similar to Figure 4 One side of the biosensor 4 is pressed by the groove wall of the fixing groove 31 of the fixing seat 3 and fixed to the fixing groove 31, whereby the biosensor 4 can be more tightly connected with the conductive member 331 after being inserted into the fixing groove 31. A circuit diagram of a conductive member is shown in FIG. Fig.21 , Fig. 22 As shown, the working electrode 42 and the counter electrode 43 of the biosensor 4 are formed on the same surface of the substrate 41 and are spaced apart from each other along the first axis L1 direction. When the sensor module 100 is not installed to the electronic signal sensor 2, the electrical contact 251 is in an open circuit state. When the sensor module 100 is installed to the electronic signal sensor 2, the electrical contact 251 is electrically connected to the sensor unit 23 via the sensor module 100, allowing the battery 24 to supply power to the sensor module 100 and the sensor unit 23 to perform the detection function of the biosensor device. It is worth noting that Fig.21 and 22 The only difference is: Fig.21 The electrical contact 251 in is connected to the different conductive layers 331b of the conductive member 331, and Fig. 22 The electrical contact 251 in is connected to the same conductive layer 331b of the conductive member 331.

[0071] In short, no matter whether the number of the conductive members 331 is one or two, the battery 24 of the electronic signal sensor 2 of this embodiment does not consume power when the electronic signal sensor 2 is not connected to the sensor module 100. Only when the electronic signal sensor 2 is connected to the sensor module 100, the electrical contact 251 is electrically connected to the sensor unit 23 and the biosensor 4 through the conductive member 331 to perform the detection function of the biosensor device.

[0072] It is worth noting that in the present embodiment, each electrical contact 251 is connected to two conductive layers 331 b, but the number is not limited to two. In other variations of the embodiment, each electrical contact 251 may be connected to one or more than three conductive layers 331 b.

[0073] Fig.23 This is a flow chart of the power startup method of the biosensor device of the present invention. Figure 6 , Fig. 9 and Fig.19 The power startup method of the biosensor device of the present invention comprises the following steps:

[0074] Step 501: Install the biosensor 4 and the elastic conductive member 331 to the sensor fixing base 3, clamp the signal output segment 402 of the biosensor 4 by the elastic conductive member 331, and fix it in the fixing groove 31 of the sensor fixing base 3 to form the sensor module 100.

[0075] Among them, in this preferred embodiment, the biosensor 4 is fixed to the sensor fixing base 3 by clamping two elastic conductive members 331. The conductive member 331 adopts the conductive rubber with a layered structure mentioned above. The conductive rubber is squeezed by the groove wall of the fixing groove 31 so that it is tightly attached to the biosensor 4, and stable electrical conduction can be achieved without bonding the two together through any adhesive.

[0076] Step 502 : Combine the sensor module 100 with the implant device 90 and the guide needle 91 .

[0077] Step 503 : Combining the electronic signal sensor 2 with the implant device 90 .

[0078] In this preferred embodiment, the sensor module 100 and the guide needle 91 are pre-combined to the implant device 90 , and then the implant device 90 is combined with the electronic signal sensor 2 , but at this time the sensor module 100 is not combined with the electronic signal sensor 2 .

[0079] Step 504: Place the implant device 90 on the skin surface and apply pressure to make the electronic signal sensor 2 adhere to the skin surface.

[0080] Step 505: The sensor module 100 is combined with the base 21 of the electronic signal sensor 2 through the implant device 90, and the sensing segment 401 of the biosensor 4 is partially implanted subcutaneously to form the biosensor device.

[0081] The step 505 is the implantation step of the biosensor 4, wherein the implantation device 90 provides an external force to the sensor module 100 and pushes the sensor module 100 to quickly connect to the base 21 of the electronic signal sensor 2, and at the same time, the sensing segment 401 of the biosensor 4 is partially implanted subcutaneously under the guidance of the guide needle 91 to measure physiological signals in the body, wherein the electrical contact 251 of the circuit signal unit 25 of the electronic signal sensor 2 forms a switch and connects to the battery 24, and the electrical contact 251 is usually maintained in an open circuit state, so that the circuit connected to the battery 24 is broken, so that no current will flow through, thereby maintaining the power of the battery 24 in a saturated state to avoid the problem of power consumption during storage, so that the battery can provide sufficient power for the biosensor device to perform detection for a predetermined time.

[0082] Step 506 : Push the sensor module 100 to an activation position through the implant device 90 , and maintain the sensor module 100 at the activation position, so that the conductive member 331 on the sensor module 100 contacts the electrical contact 251 .

[0083] Step 507: Activate the battery 24 of the electronic signal sensor 2 to provide power to the sensor module 100 to perform the detection function of the biological sensing device.

[0084] In summary, since the biosensor 4 will not be bent substantially before and after being implanted into the organism, the risk of damage can be reduced. Therefore, the purpose of the present invention can be achieved. In addition, the sensor module 100 and the electronic signal sensor 2 of the present invention are split into two modules, that is, before the biosensor device is used, the sensor module 100 and the electronic signal sensor 2 are separately set. When it is used, the sensor module 100 and the electronic signal sensor 2 are combined, and the internal battery 24 is started to supply power, so as to avoid the consumption of power of the battery 24 during storage, so that the battery power can maintain normal operation during the use of the biosensor 4.

[0085] The above are merely embodiments of the present invention and should not be used to limit the scope of the present invention. That is, any simple equivalent changes and modifications made according to the claims and description of the present invention still fall within the scope of the present invention.

Claims

1. A method for activating a biosensor device, comprising the following steps: Mounting a biosensor and at least one conductive member to a sensor mounting base to form a sensor module, wherein the conductive member is electrically connected to the biosensor; Combining the sensor module with the implant device and with the guide needle; The electronic signal sensor is combined with the implant device, and two electrical contacts of the electronic signal sensor are in an open circuit state; Placing the implant device on the skin surface and applying pressure to make the electronic signal sensor adhere to the skin surface; The sensor module is combined with the base of the electronic signal sensor, and the sensing section of the biosensor is passed through the base of the electronic signal sensor; Pushing the sensor module to an activation position through the implant device, and causing the conductive member to contact the electrical contact of the electronic signal sensor; and The battery of the electronic signal sensor is activated to provide power to the sensor module to perform the detection function of the biological sensing device.

2. The method for activating a biosensor device according to claim 1, wherein: When the electrical contact on the electronic signal sensor is in the open circuit state, the battery is in a completely power-off state.

3. The method for activating a biosensor device according to claim 1, wherein: The biosensor and the conductive member are mounted on the sensor fixing seat to form the sensor module. The conductive member is a layered structure consisting of a plurality of conductive layers and a plurality of insulating layers stacked alternately and stacked along a first axis.

4. The method for activating a biosensor device according to claim 3, wherein: The electronic signal sensor is combined with the implant device along a second axis direction, and the second axis direction is not parallel to the first axis direction.

5. The method for activating a biosensor device according to claim 4, wherein: The first axis and the second axis are located in the same plane and form an angle therebetween. The angle remains substantially unchanged before and after the sensing section of the biosensor passes through the base of the electronic signal sensor.

6. The method for activating a biosensor device according to claim 3, wherein: The number of the conductive members is two, the biosensor has a working electrode and a counter electrode, the two conductive members are electrically connected to the working electrode and the counter electrode respectively, and the electrical contacts are electrically connected to at least one conductive layer of one of the conductive members respectively.

7. The method for activating a biosensor device according to claim 1, wherein: The sensor fixing seat has a fixing groove for fixing the conductive element and the biosensor. The conductive element is pressed by the groove wall of the fixing groove of the sensor fixing seat to further tightly connect with the biosensor.

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