Traditional Chinese medicine composition for treating radiotherapy-induced skin injury and application of traditional Chinese medicine composition

Abstract

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating radiotherapy-induced skin injury and application thereof, and the traditional Chinese medicine composition comprises astragalus membranaceus, rheum officinale, scutellaria baicalensis, golden cypress, mint, coptis chinensis, cortex dictamni, radix sophorae flavescentis, honeysuckle, gypsum and divaricate saposhnikovia root. Astragalus mongholicus is used as a monarch material, and is used for tonifying qi and drawing toxin and promoting tissue regeneration to heal sore; rheum officinale, scutellaria baicalensis, cortex phellodendri and coptis chinensis synergistically clear away heat and toxic materials and eliminate dampness and purge fire, which are the important basis of toxin expelling and detoxification. Mint, cortex dictamni, radix sophorae flavescentis and honeysuckle have the effects of dispelling wind and relieving itching, clearing heat and drying dampness, resolving dampness and detoxifying, and both symptom improvement and pathology root are considered; the gypsum clears heat and purges fire, the divaricate saposhnikovia root dispels wind evil, assists the whole prescription in directly clearing heat toxin and expelling evil, and integrally achieves multiple effects of expelling toxin and removing necrotic tissue, clearing away heat and toxic materials, eliminating dampness and relieving itching, and dispelling wind and evil.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition for treating radiotherapy-induced skin damage and application thereof. Background Art

[0002] Radiotherapy is one of the important means of treating malignant tumors in modern medicine. It uses high-energy rays to directly destroy the DNA structure of cancer cells, thereby inhibiting their proliferation and growth. However, while radiotherapy kills tumor cells, it also inevitably causes damage to surrounding normal tissues, especially the skin. Skin damage after radiotherapy is a common complication, manifested as erythema, edema, and peeling, and in severe cases can lead to skin necrosis and ulceration. This damage not only affects the patient's quality of life, but may also lead to infection, delayed wound healing, and even affect the follow-up treatment.

[0003] At present, the clinical treatment methods for skin damage after radiotherapy mainly include topical application of antibiotics, hormone drugs, wound care and surgical debridement. However, these methods have many limitations. First, long-term use of antibiotics may lead to the emergence of drug-resistant strains, reduce efficacy, and increase the difficulty of infection control. Secondly, although hormone drugs can temporarily relieve inflammatory reactions, long-term use may cause side effects such as hormone dependence and skin atrophy, which is not conducive to long-term healing of wounds. In addition, traditional wound care measures have limited effects on large-area ulcerated and necrotic wounds, especially for patients with complex pathogenesis such as qi deficiency, damp-heat and toxic evil accumulation, the efficacy is often unsatisfactory. Although surgical debridement can effectively remove necrotic tissue, it is traumatic, the patient recovers slowly, and it cannot solve the problem of deep toxic evil.

[0004] In traditional Chinese medicine theory, skin necrosis and ulceration after radiotherapy belongs to the category of "heat toxic sores", and its pathogenesis is mainly due to qi deficiency, internal accumulation of damp-heat toxic evil, and poor circulation of qi and blood. Traditional Chinese medicine has unique advantages in regulating the body's immunity, improving microcirculation, and promoting wound healing. However, there is still a lack of scientific and systematic research and development of traditional Chinese medicine formulas or preparations for skin necrosis and ulceration after radiotherapy, and most of the traditional Chinese medicine prescriptions used in clinical practice are empirical medications, which have the following problems: 1. Lack of targeted combinations: Existing Chinese medicine prescriptions are mostly based on a single "clearing heat and detoxifying" or "drying dampness and relieving itching", lacking comprehensive consideration of complex pathogenesis such as qi deficiency, toxic evil, dampness and heat, and have limited efficacy.

[0005] 2. Single form of drug application: Traditional Chinese medicine is mostly oral decoctions, but the development and application of external treatments are insufficient, which limits the role of Chinese medicine in wound care.

[0006] 3. Lack of standardization and modernization research: The compatibility and dosage of existing Chinese medicine prescriptions mostly rely on traditional experience, lack of systematic modern pharmacological verification and dosage optimization research, and the preparation form and administration method are relatively backward, which can hardly meet modern clinical needs.

[0007] In response to the above problems, the present invention proposes a Chinese medicine composition for treating radiotherapy-induced skin damage and its application, which comprehensively covers the complex pathogenesis of skin damage after radiotherapy, has the comprehensive effects of invigorating qi, clearing away heat, drying dampness and activating blood circulation, and at the same time directly acts on the lesions through external application, reduces systemic side effects, and improves the patient's treatment experience and compliance. Summary of the invention

[0008] The object of the present invention is to provide a Chinese medicine composition for treating radiotherapy skin damage and application thereof, with astragalus as the main ingredient, and invigorating qi, detoxifying, promoting tissue regeneration and healing sores as the core; rhubarb, scutellaria, phellodendron and coptis chinensis cooperate in clearing away heat and detoxifying, drying dampness and purging fire, which is an important basis for detoxifying; peppermint, dactyly, sophora flavescens and honeysuckle can dispel wind and relieve itching, clear away heat and dry dampness, transform dampness and detoxify, and take into account both symptom improvement and pathological root causes; gypsum can clear away heat and purge fire, and saposhnikovia can dispel wind evil, assisting the whole prescription in directly clearing heat and toxins and expelling evil, and achieving the multiple effects of detoxifying and purging rot, clearing heat and detoxifying, drying dampness and relieving itching, and dispersing wind and evil as a whole.

[0009] In order to achieve the above technical objectives and the above technical effects, the present invention is implemented through the following technical solutions: A traditional Chinese medicine composition for treating radiotherapy-induced skin damage comprises: astragalus, rhubarb, scutellaria, phellodendron, mint, coptis root, licorice root, sophora flavescens, honeysuckle, gypsum and siler.

[0010] Furthermore, the weight ratio of the raw materials of the Chinese medicine composition is: 0.5-4 parts of astragalus, 0.8-4 parts of rhubarb, 0.5-2 parts of scutellaria, 0.5-2 parts of phellodendron, 0.5-1 parts of coptis, 1-4 parts of dittany, 1-4 parts of sophora flavescens, 1-3 parts of honeysuckle, 1-3 parts of mint, 1 part of gypsum, and 1-2 parts of siler.

[0011] Furthermore, the weight ratio of the raw materials of the Chinese medicine composition is: 1 part of Astragalus, 1 part of Rhubarb, 1 part of Scutellaria, 1 part of Phellodendron, 1 part of Coptis, 1 part of Dictamni, 1 part of Sophora flavescens, 1 part of Honeysuckle, 1 part of Mint, 1 part of Gypsum, and 1 part of Saposhnikovia.

[0012] Decoction of Chinese herbal medicines for 1 hour. Choose the decoction solution close to body temperature for soaking for 10-15 minutes each time. Soak once or twice a day depending on the severity of the skin reaction.

[0013] On the other hand, the present invention provides a Chinese medicine preparation for treating radiotherapy-induced skin damage, wherein the Chinese medicine preparation is an external-use medicine prepared from the above-mentioned Chinese medicine composition.

[0014] Furthermore, the topical medication includes but is not limited to decoctions, ointments, tinctures, sprays and dressings.

[0015] On the other hand, the present invention proposes the use of the above-mentioned Chinese medicine composition in the preparation of a medicine for treating skin necrosis and ulceration after radiotherapy.

[0016] Beneficial effects of the present invention: Astragalus membranaceus is the main herb in the prescription and runs through the whole prescription. It has the functions of replenishing qi, expelling toxins, promoting tissue regeneration and healing sores. According to traditional Chinese medicine, if qi is deficient, toxins are difficult to be discharged, and sores will not heal for a long time. Astragalus membranaceus is sweet in taste and slightly warm in nature. It enters the spleen and lung meridians, replenishes qi, strengthens the exterior, expel toxins and promotes tissue regeneration. Its function is to strengthen the positive qi to expel evil spirits, and at the same time promote the healing of skin wounds, laying the foundation for the whole prescription to treat the disease and seek the root cause.

[0017] The assistant herbs rhubarb, scutellaria baicalensis, phellodendron chinense and coptis chinensis are all used for clearing away heat, detoxifying, drying dampness and purging fire. The four herbs used together can not only clear away internal heat, but also eliminate dampness and toxins, and work together to enhance the effects of clearing heat, detoxifying, drying dampness and purging fire.

[0018] Rhubarb is bitter and cold in nature, and is good at purging fire and detoxifying, promoting blood circulation and removing blood stasis. It is especially suitable for the symptoms of ulceration and decomposition. Its function of decomposition and pus discharge allows the necrotic tissue to be discharged, while clearing the bowels and relieving heat to avoid the accumulation of toxic evil. Scutellaria baicalensis is bitter and cold in nature. It enters the lung, stomach, and large intestine meridians, purging fire and detoxifying, drying dampness and clearing heat. When used with Phellodendron chinense and Coptis chinensis, it is especially good at drying dampness and removing evil. It is particularly effective for the condition of local damp-heat stagnation and sloughing of the skin after radiotherapy. Phellodendron chinense clears heat and dries dampness, purging fire and detoxifying, especially entering the lower part of the body, and can clear dampness and heat in the lower part of the body. It cooperates with Scutellaria baicalensis to achieve the effect of clearing dampness and heat from head to toe. Coptis chinensis is bitter, cold and dehumidifies, and is good at clearing heart fire and drying dampness and heat. It has a strong targeting effect on the pathogenesis of redness, swelling, heat and pain at the edge of ulcers, and the combination of dampness, heat, blood stasis and toxicity. It is also compatible with Scutellaria baicalensis and Phellodendron chinense to form a "Coptis chinensis, Phellodendron chinense, and Scutellaria baicalensis" combination, forming a powerful heat-clearing and detoxification system.

[0019] Auxiliary drugs such as mint, white peony root, sophora flavescens, and honeysuckle are used to assist the main and auxiliary drugs. On the one hand, they enhance the effects of clearing heat, detoxifying, and drying dampness, and on the other hand, they take into account multiple effects such as local antipruritic, anti-infection, and dehumidification and astringency.

[0020] Peppermint is pungent and cool in nature. It enters the lung and liver meridians, dispels wind-heat, and clears the head. It is used topically on skin necrosis wounds after radiotherapy. It can clear away superficial heat, dispel heat evil on the skin surface, and relieve the patient's burning sensation and discomfort of skin itching. At the same time, it dispels wind and dredges the meridians, which is conducive to the excretion of evil from the wound. Dictamni is cold in nature and bitter in taste. It enters the spleen, stomach, and bladder meridians. It has the functions of clearing heat and drying dampness, dispelling wind and relieving itching. It is especially good at treating damp-heat sores on the skin. It is used together with Scutellaria baicalensis, Phellodendron chinense, and Rhubarb to strengthen the removal of damp-heat toxins, and at the same time play a role in relieving itching and alleviating the symptoms of ulcerated skin sensitivity. Sophora flavescens is bitter, cold, and moist in nature. It clears heat and dries dampness, kills insects and relieves itching. It is combined with Dictamni to strengthen the function of clearing dampness, dispelling heat, and relieving itching. The two work together to target the inflammatory reaction caused by damp-heat in the skin, relieve symptoms, improve the local microenvironment, and help repair the wound. Honeysuckle is an excellent product for clearing away heat and detoxifying. It is sweet and cold in nature, and enters the heart, lung, and stomach meridians. It can not only clear away heat and detoxify, but also dispel wind-heat, disperse stagnation and reduce swelling. When used together with the above-mentioned medicines, it can enhance the effects of clearing heat and detoxifying, anti-inflammatory and reducing swelling. It is especially effective in relieving local stagnation of toxins in skin wounds after radiotherapy.

[0021] The medicinal materials gypsum and saposhnikovia play a guiding and synergistic role in the prescription, while also taking into account the effects of clearing away heat, relieving exterior symptoms, and expelling wind and dampness.

[0022] Gypsum is a heat-clearing and fire-purging medicine. It is pungent and sweet, and is very cold. It enters the lung and stomach meridians. It is good at clearing away the heat of the qi. It can significantly reduce the burning and redness of the skin after radiotherapy, and relieve the congestive inflammatory reaction of the tissues around the wound. It is very cold and not greasy, and has the power to lead the heat downward, coordinating all the medicines to reach the diseased area. Saposhnikovia divaricata is a wind-dispelling and antipyretic medicine. It is pungent, sweet and slightly warm. It enters the spleen, liver and bladder meridians. It is good at dispelling wind and dampness, relieving itching and detoxification. It can especially relieve local itching and skin sensitivity of ulcers, and relieve the evil toxins from the surface. At the same time, it acts as a meridian-guiding medicine to enhance the overall synergy of the drug effects of the whole prescription.

[0023] The whole formula is mainly based on Astragalus, with the core of invigorating Qi, expelling toxins, promoting tissue regeneration and healing sores; Rhubarb, Scutellaria, Phellodendron, and Coptis chinensis work together to clear away heat and detoxify, dry dampness and purge fire, which is an important basis for expelling toxins and detoxifying; Peppermint, Dictamni, Sophora flavescens, and Honeysuckle can dispel wind and relieve itching, clear heat and dry dampness, transform dampness and detoxify, taking into account both symptom improvement and the root cause of pathology; Gypsum clears heat and purges fire, and Saposhnikovia dispels wind evil, assisting the whole formula in clearing heat and toxins and expelling evil, achieving the multiple effects of expelling toxins and rot, clearing heat and detoxifying, drying dampness and relieving itching, and dispersing wind and evil.

[0024] The combination of the present invention embodies the traditional Chinese medical concept of "positive energy exists inside, evil cannot invade", clears away heat while invigorating qi, and expel toxins on the basis of clearing heat. Expelling toxins also dries dampness and astringes, and dispels wind and dissipates heat while eliminating dampness. It takes into account both the symptoms and the root cause, and treats both the inside and the outside, providing a more comprehensive treatment plan for the treatment of skin necrosis and ulceration after radiotherapy.

[0025] Of course, any product implementing the present invention does not necessarily need to achieve all of the advantages described above at the same time. DETAILED DESCRIPTION

[0026] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention. Example 1

[0027] A Chinese medicine composition for treating radiotherapy-induced skin damage as described in this embodiment includes: astragalus, rhubarb, scutellaria, phellodendron, mint, coptis, dittany, sophora flavescens, honeysuckle, mint, gypsum, and siler.

[0028] In this embodiment, the raw materials of the Chinese medicine composition include: 15g of Astragalus, 15g of Rhubarb, 15g of Scutellaria, 15g of Phellodendron, 15g of Mentha, 15g of Coptis, 15g of Dictamni, 15g of Sophora flavescens, 15g of Honeysuckle, 15g of Mentha, 15g of Gypsum, and 15g of Saposhnikovia.

[0029] Decoction the above raw materials for 1 hour. Choose 35-40℃ decoction solution for soaking for 10-15 minutes each time. Soak once or twice a day depending on the severity of the skin reaction. Example 2

[0030] The Chinese medicine composition for treating chronic diseases described in this embodiment has the following raw materials in the following weight ratios: 0.5-4 parts of Astragalus, 0.8-4 parts of Rhubarb, 0.5-2 parts of Scutellaria, 0.5-2 parts of Phellodendron, 0.5-1 parts of Coptis, 1-4 parts of Dictamni, 1-4 parts of Sophora flavescens, 1-3 parts of Honeysuckle, 1-3 parts of Menthus, 1 part of Gypsum, and 1-2 parts of Saposhnikovia. Example 3

[0031] This embodiment is aimed at patients with Qi deficiency as the main type. In this type of patients, the wound does not heal for a long time, the surrounding skin is pale or cold, there is no obvious redness, swelling, heat or pain, and the patient is generally tired and weak, with a sallow complexion, a pale tongue with a thin white coating, and a weak pulse. This is a typical manifestation of the "Qi deficiency and inability to control" syndrome in traditional Chinese medicine.

[0032] The Chinese medicine composition for treating chronic diseases described in this embodiment has the following raw materials in the following weight ratios: 4 parts of Astragalus, 0.8 parts of Rhubarb, 0.5 parts of Scutellaria, 0.5 parts of Phellodendron, 0.5 parts of Coptis, 1 part of Dictamni, 1 part of Sophora flavescens, 1 part of Honeysuckle, 1 part of Menthus, 1 part of Gypsum, and 1 part of Saposhnikovia.

[0033] Focus on replenishing the vital energy to promote the generation of qi and blood, thereby accelerating wound healing. On the basis of the original prescription, the weight of astragalus is increased from 1 part to 4-5 parts, because astragalus has the effects of replenishing qi and detoxifying, promoting tissue regeneration and healing sores, and its addition can effectively improve the wound healing ability of patients with qi deficiency. At the same time, in order to avoid the side effects of too strong cold or heat-clearing drugs on patients with qi deficiency, the dosage of coptis chinensis, phellodendron amurense, and scutellaria baicalensis can be reduced from 1 part to 0.5 parts respectively to weaken the intensity of clearing heat and drying dampness, so as not to damage the vital energy. In addition, the amount of rhubarb should also be adjusted to 0.5-0.8 parts to avoid excessive purging of fire and detoxification to damage the patient's spleen and stomach. The dosage of mint can remain unchanged (1 part) to play its role in assisting the evacuation of heat and toxins, but it should not be used too much to avoid consuming the patient's qi and blood. Such an adjustment makes the prescription as a whole tend to replenish deficiency and detoxify, while taking into account the slight heat-clearing and detoxifying effects, avoiding the problem of further loss of vital energy caused by "too cold". Example 4

[0034] For patients with damp-heat and toxic evil accumulation type, the symptoms include redness, swelling, heat and pain in the wound, abundant and sticky secretions, local burning sensation, accompanied by purulent secretions, red tongue with yellow greasy coating, and slippery and rapid pulse. This is a typical TCM syndrome of "damp-heat and toxic evil accumulation".

[0035] The Chinese medicine composition for treating chronic diseases described in this embodiment has the following raw materials in the following weight ratios: 0.5 parts of Astragalus, 3 parts of Rhubarb, 2 parts of Scutellaria, 2 parts of Phellodendron, 1 part of Coptis, 2 parts of Dictamni, 2 parts of Sophora flavescens, 1 part of Honeysuckle, 2 parts of Menthus, 1 part of Gypsum, and 1 part of Saposhnikovia.

[0036] The treatment focuses on clearing heat, detoxifying and drying dampness, while taking into account the promotion of blood circulation and promoting wound metabolism. On the basis of the original prescription, it is recommended to increase the dosage of Scutellaria baicalensis and Phellodendron chinense from 1 to 3 parts. Scutellaria baicalensis and Phellodendron chinense are good at clearing heat, drying dampness and detoxifying, and can directly target the inflammatory reaction of the wound caused by damp-heat toxic evil; the dosage of Sophora flavescens and Dictamni cortex should also be increased from 1 to 2-3 parts. Sophora flavescens has the effect of drying dampness, detoxifying and relieving itching, and Dictamni cortex has the outstanding effect of clearing heat and drying dampness, which can relieve the symptoms of wound redness, swelling and itching. In addition, the dosage of Rhubarb can be increased to 2 parts. Rhubarb has the effects of purging fire and detoxifying, promoting blood circulation, removing blood stasis, clearing the bowels and detoxifying, and is conducive to the rapid excretion of damp-heat toxic evil. In order to avoid the damage of cold and cool drugs to the body, the dosage of Astragalus membranaceus should be appropriately reduced from 1 part to 0.5 parts, so that the overall prescription focuses more on eliminating evil rather than strengthening the body. At the same time, in order to relieve the symptoms of heat and toxicity, the amount of mint can be appropriately increased to 2 parts. Its effects of clearing away heat and detoxifying, dispelling wind and relieving itching can improve the patient's discomfort. The adjusted prescription focuses on the intensity of clearing heat and drying dampness, while avoiding the harm of large doses of cold drugs to patients. By enhancing the dehumidifying and detoxifying effects of the drugs, it promotes the rapid drying, scabbing and healing of the wound surface. Example 5

[0037] Patients with severe dampness and toxins, obvious wound exudation, erosion, and severe itching usually belong to the TCM "dampness and toxins descending" syndrome. The pathogenesis is that dampness and toxins are retained in the skin and qi and blood circulation is not smooth.

[0038] The Chinese medicine composition for treating chronic diseases described in this embodiment has the following raw materials in the following weight ratios: 0.8 parts of Astragalus, 1.5 parts of Rhubarb, 3 parts of Scutellaria, 3 parts of Phellodendron, 1 part of Coptis, 4 parts of Dictamni, 4 parts of Sophora flavescens, 1 part of Honeysuckle, 3 parts of Menthus, 1 part of Gypsum, and 1 part of Saposhnikovia.

[0039] It is necessary to strengthen the effect of clearing heat, drying dampness and detoxifying, while focusing on relieving local dampness and itching symptoms. On the basis of the original prescription, the dosage of Dictamni and Sophora flavescens should be increased from 1 part to 3-4 parts respectively. Dictamni has strong heat-clearing, damp-drying and antipruritic effects, while Sophora flavescens not only has damp-drying and detoxifying effects, but also has antifungal effects, which are particularly suitable for patients with dampness and toxic exudation; the dosage of mint can also be increased to 3 parts to enhance the effects of dispersing wind and relieving itching, dispersing wind and clearing heat. The dosage of Scutellaria baicalensis and Phellodendron chinense is adjusted to 2-3 parts to further strengthen the effect of drying dampness, so as to facilitate the elimination of dampness and toxicity. The dosage of Coptis chinensis can be maintained at 1 part, while the dosage of Rhubarb is adjusted to 1.5-2 parts, which further strengthens the effects of purging heat and detoxifying, clearing the bowels and detoxifying, and helps to eliminate dampness and toxicity. For such patients, since the vital energy has not yet been significantly deficient, the dosage of Astragalus membranaceus can be maintained at 1 part or slightly reduced to 0.8 parts to avoid promoting dampness and stagnation of evil. Through such adjustments, the prescription can significantly alleviate the symptoms of wound erosion, exudation and itching caused by the accumulation of dampness and toxins, and make the wound gradually dry and smooth. Example 6

[0040] For patients with severe heat and toxicity accompanied by local necrosis, the symptoms are local tissue necrosis on the wound surface, redness, swelling and heat at the edges, accompanied by foul-smelling secretions. The pathogenesis is "heat and toxicity stagnation, and the rotten flesh has not fallen off."

[0041] The Chinese medicine composition for treating chronic diseases described in this embodiment has the following raw materials in the following weight ratios: 0.8-1 part of Astragalus, 4 parts of Rhubarb, 1 part of Scutellaria, 1 part of Phellodendron, 1 part of Coptis, 1 part of Dictamni, 1 part of Sophora flavescens, 2-3 parts of Honeysuckle, 1 part of Menthus, 1 part of Gypsum, and 2 parts of Saposhnikovia.

[0042] The key to the treatment of such patients is to clear away heat and detoxify, remove rotten flesh and promote tissue regeneration. On the basis of the original prescription, the dosage of rhubarb should be increased from 1 to 3-4 parts. Rhubarb can purge fire and detoxify, promote blood circulation and remove blood stasis, and has the effects of softening and eliminating accumulation, and removing rotten flesh. It is an important medicine for treating raging heat and toxicity; the dosage of honeysuckle should also be increased from 1 to 2-3 parts. Honeysuckle has a significant effect of clearing heat and detoxifying, and can alleviate local infection reactions; the dosage of coptis chinensis and phellodendron can be increased to 2 parts to further enhance the detoxification effect; the dosage of saposhnikovia divaricata is adjusted to 2 parts, and its effect of dispersing wind and unblocking collaterals is helpful for the excretion of heat and toxicity; at the same time, the dosage of astragalus can be maintained at 1 part or slightly reduced to 0.8 parts, so as to avoid the difficulty in completely removing the toxic evil due to excessive strengthening of the body. The adjusted prescription pays equal attention to clearing away heat and detoxification, removing rotten flesh and promoting tissue regeneration, which can quickly improve the pathological state of raging heat and toxicity and rotten flesh, and create good conditions for wound repair.

[0043] The preferred embodiments of the present invention disclosed above are only used to help illustrate the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to the specific implementation methods described. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present invention, so that those skilled in the art can understand and use the present invention well. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. A Chinese medicine composition for treating radiotherapy-induced skin damage, characterized in that: include: Astragalus, rhubarb, scutellaria, phellodendron, mint, coptis, dittany, sophora flavescens, honeysuckle, gypsum, and siler.

2. The Chinese medicine composition according to claim 1, characterized in that: The raw materials of the Chinese medicine composition are proportioned in parts by weight: 0.5-4 parts of astragalus, 0.8-4 parts of rhubarb, 0.5-2 parts of scutellaria, 0.5-2 parts of phellodendron, 0.5-1 parts of coptis, 1-4 parts of dittany, 1-4 parts of sophora flavescens, 1-3 parts of honeysuckle, 1-3 parts of mint, 1 part of gypsum, and 1-2 parts of siler.

3. The Chinese medicine composition according to claim 1, characterized in that: The raw materials of the Chinese medicine composition are proportioned in parts by weight: 1 part of astragalus, 1 part of rhubarb, 1 part of scutellaria, 1 part of phellodendron, 1 part of coptis, 1 part of licorice root, 1 part of sophora flavescens, 1 part of honeysuckle, 1 part of mint, 1 part of gypsum, and 1 part of siler.

4. A Chinese medicine product for treating radiotherapy-induced skin damage, characterized in that: The Chinese medicine product is an external medicine prepared from the Chinese medicine composition according to any one of claims 1 to 3.

5. The Chinese medicine product according to claim 4, characterized in that: The oral medications include but are not limited to decoctions, ointments, tinctures, sprays and dressings.

6. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a medicament for treating skin necrosis and ulceration after radiotherapy.