Composition for inducing relaxation effect

Abstract

The present invention is a composition for inducing a relaxation effect. Provided is a composition in which crude drugs having a relaxing effect inducing effect are combined. A composition for inducing a relaxing effect, which contains rhizoma zingiberis, ginseng and jujube as active ingredients.

Description

Technical Field

[0001] The present invention relates to a composition for inducing relaxation effect. Background Art

[0002] In our busy modern society, people are constantly under stress in their daily lives. An increasing number of people report not only physical discomfort but also mental problems. Sometimes people fall into an unstable mental state with increasing feelings of uneasiness and anxiety.

[0003] Although crude drugs have pharmacological effects alone, they are used in the treatment and prevention of various diseases and symptoms as a combination of various crude drugs in traditional Chinese medicine prescriptions. As a combination of crude drugs other than such traditional Chinese medicine prescriptions, for example, it has been reported that a combination of gardenia, dried ginger, liquorice and deerskin glue can improve sleep and memory (Patent Document 1), but in reality, not much research has been conducted.

[0004] Prior art literature

[0005] Patent Literature

[0006] Patent Document 1: Japanese Patent No. 7176790 Summary of the invention

[0007] Problem that the invention aims to solve

[0008] An object of the present invention is to provide a combination of herbal medicines capable of inducing a relaxation effect.

[0009] Solutions for solving problems

[0010] The present inventors have conducted intensive studies to solve the above problems and have found that a combination of dried ginger, ginseng and jujube can induce a novel relaxation effect that has not been known in the case of any of them alone, thereby completing the present invention.

[0011] That is, the present invention relates to a composition for inducing a relaxation effect, which contains dried ginger, ginseng and jujube as effective ingredients.

[0012] Effects of the Invention

[0013] By taking the composition of the present invention, a novel relaxation effect that has been unknown so far for a single herbal medicine can be induced, and various relaxation effects such as relief of neck and shoulder stiffness, improvement of cold symptoms, improvement of psychological state, improvement of loss of appetite, and improvement of awakening during sleep can be obtained. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Figure 1 Graph showing the evaluation results of the item “stiffness of neck and shoulders” in Test Example 1 using VAS.

[0015] Figure 2 This is a graph showing the evaluation results of the item “coldness of fingers” in Test Example 1 using VAS.

[0016] Figure 3 This is a graph showing the evaluation results of the item “general coldness” of Test Example 1 using VAS.

[0017] Figure 4 Graph showing the evaluation results of the item “sense of uneasiness” in Test Example 1 using VAS.

[0018] Figure 5 : is a graph showing the evaluation results of the item “lack of concentration” of Test Example 1 using VAS.

[0019] Figure 6 : is a graph showing the evaluation results of the item “no feeling of relaxation” in Test Example 1 using VAS.

[0020] Figure 7 : is a graph showing the evaluation results of the item “loss of appetite” in Test Example 1 using VAS.

[0021] Figure 8 It is a graph showing the evaluation results of the item “irritability / anxiety” of Test Example 1 using VAS.

[0022] Fig. 9 Graph showing the evaluation results of the item “mental fatigue” in Test Example 1 using VAS.

[0023] Fig.10 3 is a graph showing the evaluation results of the item “frequent waking up during sleep” in Test Example 1 using VAS. DETAILED DESCRIPTION

[0024] The relaxation effect inducing composition of the present invention uses dried ginger, ginseng and jujube as active ingredients.

[0025] Dried ginger is a herbal medicine based on a substance obtained by soaking or steaming the rhizome of ginger (Zingiber officinale Roscoe) of the Zingiberaceae family.

[0026] Ginseng is a herbal medicine based on the root obtained by removing the rootlets of Panax ginseng CA Meyer of the Araliaceae family or soaking the rootlets in hot water.

[0027] Jujube is a herbal medicine based on the fruit of jujube (Ziziphus jujuba Miller var. inermis Rehder) of the Rhamnaceae family.

[0028] In the composition of the present invention, these crude drugs can be used directly, or in the form of crude drug powders or crude drug extracts obtained by extracting the crude drugs with solvents such as water and ethanol. The crude drug extracts can be concentrated soft extracts or dried extract powders.

[0029] The content mass ratio of dried ginger, ginseng and jujube in the composition of the present invention is not particularly limited, but from the viewpoint of inducing a relaxing effect, the content mass ratio of dried ginger to ginseng (in the case of a crude drug extract, the crude drug conversion weight) is preferably 10:3 to 4:1. In addition, the content mass ratio of dried ginger to jujube (in the case of a crude drug extract, the crude drug conversion weight) is preferably 5:3 to 1:1.

[0030] The relaxation effect induction in the present invention includes the improvement of various conditions that cannot be identified as diseases, such as the relief of stiff neck / shoulder, the improvement of cold symptoms such as cold fingers or whole body, the improvement of psychological states such as uneasiness, lack of concentration, lack of relaxation, loss of appetite, irritability / restlessness, mental fatigue, and the improvement of mid-sleep awakening caused by waking up multiple times during sleep. In the present invention, the use of improving the above symptoms or conditions also includes the preventive use thereof.

[0031] The composition of the present invention includes medicines, quasi-drugs, foods, feeds, etc. for humans or animals. As dosage forms of medicines and quasi-drugs, for example, tablets, capsules, granules, powders, chewable tablets, syrups, etc. can be cited. When preparing these preparations, in addition to dried ginger, ginseng and jujube as active ingredients, pharmaceutically acceptable excipients, binders, extenders, disintegrants, surfactants, lubricants, dispersants, buffers, preservatives, flavoring agents, fragrances, coating agents, carriers, diluents, etc. can be appropriately combined as needed, and manufactured by conventional methods.

[0032] The dosage of the composition of the present invention is not particularly limited and can be appropriately set. For example, the daily dosage for an adult is about 0.4-0.6 g of dried ginger, 0.10-0.14 g of ginseng, and 0.3-0.5 g of jujube (in the case of a crude drug extract, the crude drug conversion weight).

[0033] As the form when the composition of the present invention is made into food, for example, in addition to various foods such as jelly, hard candy, soft candy, gummy candy, chewing gum, wafer biscuits, biscuits, chocolate, bread, noodles, sausages, etc. or nutritious foods, a nutritional supplement composition in the same form as the above-mentioned medicines (tablets, capsules, chewing agents, syrups, etc.) can also be cited. When preparing these foods, in addition to dried ginger, ginseng and jujube as active ingredients, other food materials or sweet seasonings, gelling agents, colorants, antifungal agents, acid seasonings, seasonings, pH regulators, swelling agents, solvents, softeners, oils, emulsifiers, preservatives, aromatics, stabilizers, colorants, antioxidants, humectants, thickeners, etc. can also be appropriately combined as needed, and manufactured according to a conventional method. Food includes functional food, specific health food, functional expression food, etc.

[0034] The composition of the present invention may be accompanied by a display for improving stiffness of the neck / shoulder, preventing / improving coldness of the fingers, preventing / improving coldness of the whole body, alleviating anxiety, improving / maintaining concentration, imparting a sense of relaxation, improving loss of appetite, alleviating impatience / anxiety, alleviating mental fatigue, improving awakening during sleep, etc. The act of accompanying the display includes: recording on the body, container, package, etc. of the product containing the composition of the present invention; recording in documents such as instructions, attachments, brochures, and other printed materials that disclose product information; recording in advertisements used for promotion including various leaflets and the Internet; etc.

[0035] Example

[0036] The present invention will be described in more detail below with reference to Examples and Test Examples, but the present invention is not limited to these Examples and the like.

[0037] Example 1

[0038] Preparation of tablets containing dried ginger, ginseng and jujube

[0039] 10 times the amount of purified water was added to the cut dried ginger, ginseng and jujube, and the mixture was heated to 95-100°C under stirring, and then extracted for about 60 minutes. After the extraction, the extract was separated into solid and liquid, and the separated liquid was concentrated under reduced pressure and then dried by spray drying to obtain dried ginger, ginseng and jujube extract powders.

[0040] The obtained dried ginger, ginseng and jujube extract powders are mixed with lactose, microcrystalline cellulose and magnesium stearate, and tableted using a tablet press to produce tablets containing 0.5 g of dried ginger, 0.14 g of ginseng and 0.4 g of jujube in terms of weight as crude drugs per 3 tablets (the total amount of dried ginger extract powder, ginseng extract powder and jujube extract powder is 90 mg).

[0041] Test Example 1

[0042] Human trials

[0043] Thirty healthy women aged 35 to 50 were selected as subjects in each group. The tablets prepared in Example 1 were taken once a day for 12 weeks. After 4 weeks, 8 weeks, and 12 weeks from the start of the intake, VAS (Visual Analogue Scale) was used to evaluate the items of "stiffness of the neck / shoulder", "coldness of the fingers", "coldness of the whole body", "uneasiness", "lack of concentration", "lack of relaxation", "loss of appetite", "irritability / anxiety", "mental fatigue", and "frequent waking up during the meal" (herbal medicine group). As a control, tablets without dried ginger, ginseng, and jujube extract powder were taken and evaluated in the same way using VAS (control group). The results are shown in Figures 1 to 10 .

[0044] As shown in these results, it can be confirmed that by taking dried ginger, ginseng and jujube together, improvements are achieved in the following items: "stiffness of neck / shoulder", "coldness of fingers", "coldness of the whole body", "feeling of uneasiness", "lack of concentration", "lack of relaxation", "loss of appetite", "feeling of impatience / anxiety", "mental fatigue", "waking up many times in the middle of the night", and the effect is enhanced over time.

[0045] Industrial Applicability

[0046] By taking the composition of the present invention, effects such as relief of neck and shoulder stiffness, improvement of cold symptoms, improvement of psychological state, improvement of loss of appetite, and improvement of awakening during sleep, which have been unknown so far for each herbal medicine alone, can be achieved, and it is useful as a drug, food, etc. for inducing relaxation effects.

Claims

1. A composition for inducing a relaxation effect, comprising dried ginger, ginseng and jujube as effective ingredients.

2. The relaxation effect inducing composition according to claim 1, wherein The relaxing effect is improvement of neck / shoulder stiffness, improvement of cold symptoms, improvement of psychological state, improvement of loss of appetite or improvement of mid-night awakening.

3. The relaxation effect inducing composition according to claim 2, wherein Cold syndrome refers to coldness of the hands and feet or coldness of the whole body.

4. The relaxation effect inducing composition according to claim 2, wherein The improvement of the mental state is a reduction in anxiety, an improvement in concentration, a feeling of relaxation, a reduction in anxiety, or a reduction in mental fatigue.

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