Biodegradable amphiphilic microsphere as well as preparation method and application thereof

The preparation of amphiphilic microspheres by physical emulsification method solves the complex problem of chemical reaction processes in the prior art, simplifies production steps, reduces costs, and achieves the effects of uniform distribution and cell proliferation in aqueous gels.

CN119570074APending Publication Date: 2025-03-07CHANGZHOU INST OF MATERIA MEDICA
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Patent Information

Application Number
CN202411765853.4
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-04
Publication Date
2025-03-07

AI Technical Summary

Technical Problem

In the existing amphiphilic microsphere preparation methods, the chemical reaction process is complex, resulting in a variety of production steps and high cost.

Method used

The amphiphilic microspheres were prepared by physical method, and the emulsification method of the oil and aqueous phases was used to generate microspheres in which the hydrophobic polymer and the hydrophilic polymer were entangled with each other, avoiding the chemical reaction steps.

Benefits of technology

The production steps are significantly simplified, the use of chemical reagents and heavy metal catalysts is reduced, and the amphiphilic microspheres are evenly distributed in the aqueous gel, which is not easy to agglomerate, and promotes tissue cells to enter the microspheres for adhesion and proliferation.

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Abstract

The invention belongs to the technical field of biomedical materials, and particularly relates to a biodegradable amphiphilic microsphere as well as a preparation method and application thereof, and the preparation method comprises the following steps: step S1, preparing an oil phase; s2, preparing a water phase; s3, adding the oil phase into the water phase, and emulsifying the polymer according to a certain stirring speed to generate a microsphere-shaped prepolymer; s4, removing the organic solvent in the microspheres in a vacuum or heating manner, and gradually curing the microspheres to obtain pre-polymerized microspheres; step S5, washing the pre-polymerized microspheres for multiple times to remove the surfactant, and screening the pre-polymerized microspheres through screens with different mesh numbers to obtain biodegradable amphiphilic microspheres with different particle size distribution; by adopting a physical method for synthesis, the chemical reaction between polymers is avoided, the production steps are remarkably simplified, the use of chemical reagents and heavy metal catalysts is reduced, and tissue cells are promoted to enter the microspheres for adhesion and proliferation.
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Citation Information

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