Antimicrobial combinations

Abstract

The present invention relates to a combination comprising (A) at least one compound selected from the group consisting of compounds of formula (I), sorbitan esters, isosorbide esters and glyceryl ethers wherein R is selected from the group consisting of saturated hydrocarbon chains having 5 to 23 carbon atoms, unsaturated hydrocarbon chains having 5 to 23 carbon atoms, and mixtures thereof; and (B) at least one hydroxamic acid or a salt thereof. # imgabs0 #

Description

Technical Field

[0001] The present invention relates to an antimicrobial combination, its use as an antimicrobial agent and a formulation comprising the antimicrobial combination. Background Art

[0002] Preservation of household and cosmetic preparations extends their shelf life and thus offers consumers a better value for money.

[0003] Furthermore, preservatives prevent consumers from spreading microorganisms in their homes or on themselves, thus providing health benefits.Antimicrobial agents are well described in the art and there are many available that offer excellent performance.

[0004] However, there is a need to provide a series of complex preservative systems, by which excellent antimicrobial performance is provided, and the level of preservative active substances is also minimized. For example, many well-known preservative active substances with excellent efficacy are not preferred due to reduced consumer acceptance, health concerns or due to regulatory restrictions. For the same reason, the level of such active substances may also be (legally) restricted. In addition, there is a need for all elements of the preservative system to meet sustainability goals and ensure that household and cosmetic formulations are as environmentally friendly as possible.

[0005] Therefore, there is a need to provide even more sophisticated preservative systems that provide excellent antimicrobial effects and are also highly accepted by consumers, do not raise health or regulatory concerns, and have excellent sustainability and environmentally friendly properties. Summary of the invention

[0006] The present invention relates to a composition comprising

[0007] (A) at least one compound selected from the group consisting of a compound of formula (I), sorbitan esters, isosorbide esters and glycerol ethers

[0008]

[0009] wherein R is selected from a saturated hydrocarbon chain having 5 to 23 carbon atoms, an unsaturated hydrocarbon chain having 5 to 23 carbon atoms, and mixtures thereof; and

[0010] (B) at least one hydroxamic acid or a salt thereof.

[0011] Advantageously, the combination of the present invention shows a synergistic effect on a wide spectrum of microorganisms. This leads to the following advantages: preparations such as cosmetic preparations or household preparations can be preserved with a smaller amount of preservatives, reducing the possibility of adverse effects from antimicrobial active substances and saving resources. Advantageously, the combination of the present invention has a high renewable carbon content. The composition of the present invention is sustainable.

[0012] The composition of the present invention comprises (A) at least one compound selected from the group consisting of a compound of formula (I), sorbitan esters, isosorbide esters and glycerol ethers.

[0013]

[0014] wherein R is selected from a saturated hydrocarbon chain having 5 to 23 carbon atoms, an unsaturated hydrocarbon chain having 5 to 23 carbon atoms, and a mixture thereof.

[0015] In one embodiment, the composition of the present invention comprises (A) at least one compound selected from the group consisting of compounds of formula (I)

[0016]

[0017] wherein R is selected from a saturated hydrocarbon chain having 5 to 23 carbon atoms, an unsaturated hydrocarbon chain having 5 to 23 carbon atoms, and a mixture thereof.

[0018] Preferably, R in formula (I) is selected from a saturated hydrocarbon chain having 5 to 17 carbon atoms, an unsaturated hydrocarbon chain having 5 to 17 carbon atoms, and a mixture thereof.

[0019] More preferably, R in formula (I) is selected from a saturated hydrocarbon chain having 5 to 13 carbon atoms, an unsaturated hydrocarbon chain having 5 to 13 carbon atoms, and a mixture thereof.

[0020] Particularly preferably, R in formula (I) is selected from a saturated hydrocarbon chain having 7 to 9 carbon atoms, an unsaturated hydrocarbon chain having 7 to 9 carbon atoms, and a mixture thereof.

[0021] In at least one embodiment, R in formula (I) is selected from -(CH2)6CH3, -(CH2)8CH3 and mixtures thereof; or R in formula (I) is selected from -(CH2) 10 CH3, -(CH2) 12 CH3, and mixtures thereof; or R in formula (Ⅰ) is selected from -(CH2)7CH=CH2, -(CH2)7CH=CHCH2CH3, and mixtures thereof; or the RC=O residue in formula (Ⅰ) is derived from coconut fatty acid; or the RC=O residue in formula (Ⅰ) is derived from soybean fatty acid.

[0022] In at least one embodiment, R in formula (I) is selected from -(CH2)6CH3, -(CH2)8CH3 and mixtures thereof. In at least one embodiment, R in formula (I) is selected from -(CH2)6CH3, -(CH2)8CH3 and mixtures thereof. 10 CH3, -(CH2) 12CH3 and mixtures thereof. In at least one embodiment, R in formula (I) is selected from -(CH2)7CH=CH2, -(CH2)7CH=CHCH2CH3 and mixtures thereof. In at least one embodiment, the RC=O residue in formula (I) is derived from coconut fatty acid; in at least one embodiment, the RC=O residue in formula (I) is derived from soybean fatty acid.

[0023] The expression "RC=O residues in formula (I) are derived from coconut fatty acids" as used herein preferably means that the carbon chain length distribution in the RC=O residues in formula (I) corresponds to the carbon chain length distribution of fatty acids in coconut oil (eg bound as triglycerides).

[0024] The expression "RC=O residues in formula (I) are derived from soybean fatty acids" as used herein preferably means that the carbon chain length distribution in the RC=O residues in formula (I) corresponds to the carbon chain length distribution of fatty acids in soybean oil (eg bound as triglycerides).

[0025] Preferably, the weight ratio of the compound according to formula (I) wherein R is (CH2)6CH3 to the compound according to formula (I) wherein R is -(CH2)8CH3 is 1:9 to 9:1, preferably 3:7 to 7:3.

[0026] Preferably, wherein R is (CH2) 10 Compounds according to formula (I) wherein R is -(CH2) 12 The weight ratio of CH3 to the compound according to formula (I) is from 1:9 to 9:1, preferably from 3:7 to 7:3.

[0027] Preferably, the weight ratio of the compound according to formula (I) wherein R is (CH2)7CH=CH2 and the compound according to formula (I) wherein R is -(CH2)7CH=CHCH2CH3 is 1:9 to 9:1, preferably 3:7 to 7:3.

[0028] Compounds of formula (I) are described, for example, in WO2018 / 002100 and EP application number EP21200587.0.

[0029] In one embodiment, the combination of the invention comprises (A) at least one compound selected from sorbitan esters and isosorbide esters.

[0030] In one embodiment, the composition of the present invention comprises (A) at least one compound selected from sorbitan esters.

[0031] Preferably, the sorbitan ester is a monoester, diester and triester of sorbitan with one or more C6-C20 fatty acids. More preferably, the sorbitan ester is a monoester or diester of sorbitan with one or more C8-C14 fatty acids. Particularly preferably, the sorbitan ester is a monoester or diester of sorbitan with caprylic acid.

[0032] Preferably, the sorbitan ester is selected from sorbitan caprylate, sorbitan stearate, sorbitan olivetate, sorbitan oleate, sorbitan caprate, sorbitan laurate, sorbitan myristate, sorbitan caproate, and mixtures thereof. Particularly preferably, the sorbitan ester is sorbitan caprylate.

[0033] In one embodiment, the combination of the invention comprises (A) at least one compound selected from isosorbide esters.

[0034] Preferably, the isosorbide ester is a monoester or diester of isosorbide and one or more C6-C20 fatty acids. More preferably, the isosorbide ester is a monoester or diester of isosorbide and one or more C8-C14 fatty acids. Particularly preferably, the isosorbide ester is a monoester or diester of isosorbide and caprylic acid.

[0035] Preferably, the isosorbide ester is selected from isosorbide caprylate, isosorbide stearate, isosorbide olivetate, isosorbide oleate, isosorbide caprate, isosorbide laurate, isosorbide myristate, isosorbide caproate, and mixtures thereof. Particularly preferably, the isosorbide ester is isosorbide caprylate.

[0036] In one embodiment, the combination of the invention comprises (A) at least one compound selected from glycerol ethers.

[0037] Preferably, the glycerol ether is a monoether or diether of glycerol and one or more C6-C20 fatty alcohols. More preferably, the glycerol ether is a monoether or diether of glycerol and one or more C8-C14 fatty alcohols. Particularly preferably, the glycerol ether is a monoether of glycerol and one or more C8 fatty alcohols.

[0038] In at least one embodiment, the glyceryl ether is selected from ethylhexylglycerol, methylheptylglycerol, caprylyl glyceryl ether, and mixtures thereof.

[0039] The combination of the present invention comprises (B) at least one hydroxamic acid or a salt thereof.

[0040] In at least one embodiment, the combination of the present invention comprises (B) at least one hydroxamic acid. In at least one embodiment, the combination of the present invention comprises (B) at least one salt of a hydroxamic acid. Examples of salts of hydroxamic acids are alkali metal salts of hydroxamic acid (e.g., sodium salts of hydroxamic acid or potassium salts of hydroxamic acid) or alkaline earth metal salts of hydroxamic acid (e.g., magnesium salts of hydroxamic acid or calcium salts of hydroxamic acid).

[0041] Preferably, the hydroxamic acid is selected from the hydroxamic acid of formula (II)

[0042]

[0043] Where R 1 Selected from saturated hydrocarbon chains having 5 to 23 carbon atoms, unsaturated hydrocarbon chains having 5 to 23 carbon atoms, and mixtures thereof.

[0044] Preferably, R in formula (II) 1 is selected from saturated hydrocarbon chains having 5 to 17 carbon atoms, unsaturated hydrocarbon chains having 5 to 17 carbon atoms, and mixtures thereof. More preferably, R in formula (II) 1 is selected from saturated hydrocarbon chains having 5 to 13 carbon atoms, unsaturated hydrocarbon chains having 5 to 13 carbon atoms, and mixtures thereof. 1 Selected from saturated hydrocarbon chains having 7 carbon atoms, unsaturated hydrocarbon chains having 7 carbon atoms, and mixtures thereof.

[0045] Preferred hydroxamic acids are selected from the group consisting of caprylhydroxamic acid, hexanohydroxamic acid, caprohydroxamic acid, laurohydroxamic acid, and mixtures thereof.

[0046] A particularly preferred hydroxamic acid is octyl hydroxamic acid. Octyl hydroxamic acid may also be referred to as caprylohydroxamic acid or octanohydroxamic acid.

[0047] Hydroxamic acids are described, for example, in EP2224973.

[0048] Preferably, the weight ratio of (A) at least one compound selected from the group consisting of compounds of formula (I), sorbitan esters, isosorbide esters and glycerol ethers to (B) at least one hydroxamic acid or a salt thereof is from 20:1 to 1:5, more preferably from 15:1 to 1:2, even more preferably from 12:1 to 1:1, particularly preferably from 10:1 to 3:1. Also preferably, the weight ratio of (A) at least one compound selected from the group consisting of compounds of formula (I), sorbitan esters, isosorbide esters and glycerol ethers to (B) at least one hydroxamic acid or a salt thereof is from 1:1 to 15:1, more preferably from 3:1 to 12:1, even more preferably from 5:1 to 10:1, particularly preferably from 6:1 to 7:1, yet particularly preferably from 8:1 to 10:1, for example 9:1.

[0049] In a preferred embodiment, the combination of the invention comprises

[0050] (A) at least one compound selected from the group consisting of compounds of formula (I)

[0051]

[0052] wherein R is selected from a saturated hydrocarbon chain having 5 to 23 carbon atoms, an unsaturated hydrocarbon chain having 5 to 23 carbon atoms, and mixtures thereof; and

[0053] (B) at least one hydroxamic acid or a salt thereof.

[0054] In a preferred embodiment, the combination of the invention comprises

[0055] (A) at least one compound selected from the group consisting of compounds of formula (I)

[0056]

[0057] wherein R is selected from a saturated hydrocarbon chain having 5 to 13 carbon atoms, an unsaturated hydrocarbon chain having 5 to 13 carbon atoms, and mixtures thereof; and

[0058] (B) at least one hydroxamic acid or a salt thereof, wherein the hydroxamic acid is selected from the group consisting of octyl hydroxamic acid, hexanoyl hydroxamic acid, hexanoyl hydroxamic acid, lauroyl hydroxamic acid, and mixtures thereof.

[0059] In a particularly preferred embodiment, the combination according to the invention comprises

[0060] (A) at least one compound selected from the group consisting of compounds of formula (I)

[0061]

[0062] wherein R is selected from -(CH2)6CH3, -(CH2)8CH3, and mixtures thereof; and

[0063] (B) at least one hydroxamic acid or a salt thereof, wherein the hydroxamic acid is octylhydroxamic acid.

[0064] In at least one embodiment, the combination of the present invention is a blend.

[0065] In at least one embodiment, the blend comprises

[0066] 25 to 99% by weight, preferably 40 to 80% by weight, more preferably 55 to 70% by weight, particularly preferably 60 to 65% by weight, based on the total weight of the blend, of (A) at least one compound selected from the group consisting of compounds of formula (I), sorbitan esters, isosorbide esters and glycerol ethers; and

[0067] 1 to 50% by weight, preferably 2 to 20% by weight, more preferably 5 to 15% by weight, particularly preferably 8 to 12% by weight, of (B) at least one hydroxamic acid or a salt thereof, based on the total weight of the blend.

[0068] In at least one embodiment, the blend is an aqueous solution.

[0069] In at least one embodiment, the blend comprises a solvent. In at least one embodiment, the blend comprises a solvent, wherein the solvent comprises water and / or an alcohol. The solvent is useful for providing the compound used in the present invention in liquid form. In at least one embodiment, the solvent is cosmetically acceptable. In at least one embodiment, the blend comprises at least 10% by weight, preferably at least 20% by weight, more preferably at least 30% by weight, and even more preferably at least 50% by weight of water. Water is useful not only for economic reasons and because it is cosmetically acceptable. Optionally, the blend comprises a water miscible or water-soluble solvent, such as a lower alkyl alcohol. In at least one embodiment, the blend comprises a C1-C5 alkyl monoalcohol, preferably a C2-C3 alkyl monoalcohol. The alcohol that may be present is particularly a lower monoalcohol or polyol with 1 to 4 carbon atoms, such as preferably ethanol or isopropanol, which is commonly used for cosmetic purposes.

[0070] Optionally, the blend contains a water-soluble polyol. In at least one embodiment, the water-soluble polyol is a polyol having two or more hydroxyl groups in the molecule. In at least one embodiment, the water-soluble polyol is selected from the group consisting of: diols such as ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, tetramethylene glycol, 2,3-butanediol, pentamethylene glycol, 2-butene-1,4-diol, hexanediol, octanediol; triols such as glycerol, trimethylolpropane, 1,2,6-hexanetriol, etc.; tetraols such as pentaerythritol; pentaols Such as xylitol (xylytol); hexahydric alcohols such as sorbitol and mannitol; polyol polymers such as diethylene glycol, dipropylene glycol, polyethylene glycol, polypropylene glycol, tetraethylene glycol, diglycerol, polyethylene glycol, triglycerol, tetraglycerol, polyglycerol; glycol alkyl ethers such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monohexyl ether, ethylene glycol mono-2-methylhexyl ether, ethylene glycol isoamyl ether, ethylene glycol benzyl ether, Ethylene glycol isopropyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether; glycol alkyl ethers such as diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol butyl ether, diethylene glycol methyl ethyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether, propylene glycol isopropyl ether, dipropylene glycol methyl ether, dipropylene glycol ethyl Ether, dipropylene glycol butyl ether; glycol ether esters such as ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether acetate, ethylene glycol diadipic acid ester, ethylene glycol disuccinate, diethylene glycol monoethyl ether acetate, diethylene glycol monobutyl ether acetate, propylene glycol monomethyl ether acetate, propylene glycol monoethyl ether acetate, propylene glycol monopropyl ether acetate, propylene glycol monophenyl ether acetate; glycerol monoalkyl ethers such as wood alcohol (xyl alcohol); alcohol), squalane alcohol, batyl alcohol; sugar alcohols such as sorbitol, maltol, maltotriose, mannitol, sucrose, erythritol, glucose, fructose, starch sugar, maltose, xylytose, starch sugar reducing alcohol, glysolid, tetrahydrofurfuryl alcohol, POE tetrahydrofurfuryl alcohol, POP butyl ether, POPPOE butyl ether, tripolyoxypropylene glycerol ether, POP glycerol ether, POP glycerol ether phosphoric acid, POP POE pentaerythritol ether, and mixtures thereof.

[0071] In a preferred embodiment, the blend comprises a solvent selected from the group consisting of: water, glycols, ethanol, and mixtures thereof. In a preferred embodiment, the blend comprises water.

[0072] In a preferred embodiment, the blend comprises an aqueous, alcoholic or aqueous-alcoholic solvent, wherein the aqueous, alcoholic or aqueous-alcoholic solvent comprises water, ethanol, propanol, isopropanol, 1,2-propylene glycol, 1,3-propylene glycol, isobutanol, butanol, butyl glycol, butyl diethylene glycol, glycerol, or a mixture thereof; preferably wherein the aqueous, alcoholic or aqueous-alcoholic solvent comprises water, ethanol, propanol, isopropanol, 1,2-propylene glycol, 1,3-propylene glycol, glycerol, or a mixture thereof; more preferably, wherein the aqueous, alcoholic or aqueous-alcoholic solvent comprises water, isopropanol, 1,2-propylene glycol, 1,3-propylene glycol, or a mixture thereof; even more preferably, wherein the aqueous, alcoholic or aqueous-alcoholic solvent consists of water or consists of a mixture of water and an alcohol, wherein the alcohol is selected from isopropanol, 1,2-propylene glycol and 1,3-propylene glycol.

[0073] Optionally, the combination of the invention comprises (C) at least one additional antimicrobial agent.

[0074] Optionally, the blends of the present invention comprise (C) at least one additional antimicrobial agent.

[0075] In at least one embodiment, the antimicrobial agent is selected from the group consisting of aromatic alcohols, organic acids and salts thereof, compounds according to formula (P), alkyl glycols, halogenated compounds, isothiazolinones, and mixtures thereof; wherein formula (P) is as follows:

[0076]

[0077] in

[0078] R 1 ' is H, unsubstituted or halogen-substituted, branched or unbranched C1-C 20 -alkyl, unsubstituted or substituted by halogen C5-C8-cycloalkyl, unsubstituted or substituted by halogen C6-C 10 -aryl group or unsubstituted or halogen substituted, branched or unbranched C7-C 20 - aralkyl groups;

[0079] R 2 ' is O or S;

[0080] R 3 ' is H or a C1-C4-alkyl group;

[0081] X + It is a cation.

[0082] Preferably, R 3 ' is methyl.

[0083] In at least one embodiment, the aromatic alcohol is selected from the group consisting of benzyl alcohol, phenoxyethanol, resveratrol, propylene phenoxyethanol, phenylethanol, phenylpropanol, vanillin, 2-methyl-1-phenyl-2-propanol, and mixtures thereof.

[0084] In at least one embodiment, the organic acid and its salts are selected from the group consisting of benzoic acid, sorbic acid, dehydroacetic acid, lactic acid, salicylic acid, p-methoxybenzoic acid, undecylenic acid, glycolic acid, propionic acid, levulinic acid, and mixtures thereof.

[0085] In at least one embodiment, the compound according to formula (P) is selected from the group consisting of: 2-hydroxypyridine-N-oxide, 2-thiopyridine-1-oxide and its salt, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone and its salt (preferably monoethanolamine salt), and mixtures thereof. Formula (P) discloses and includes tautomeric equivalents of these compounds, because equilibrium always exists. In at least one embodiment, the compound according to formula (P) is piroctone olamine (hydroxypyrrolidone).

[0086] In at least one embodiment, the alkyl diol is selected from the group consisting of 1,2-pentanediol, 1,2-hexanediol, 1,6-hexanediol, 1,2-octanediol, 1,2-heptanediol, 1,2-decanediol, methylpropanediol, and mixtures thereof.

[0087] In at least one embodiment, the halogenated compound is selected from the group consisting of chlorhexidine and its salts, triclosan, chlorphenesin, triclocarban, chloroxylenol, iodopropynyl butylcarbamate, bronopol, climbazole, and mixtures thereof.

[0088] In at least one embodiment, the isothiazolinone is selected from the group consisting of methylisothiazolinone, methylchloroisothiazolinone, benzylisothiazolinone, and mixtures thereof.

[0089] In at least one embodiment, the antimicrobial agent is selected from the group consisting of aromatic alcohols, organic acids and their salts, hydroxypyridones, alkyl glycols, halogenated compounds, isothiazolinones, and mixtures thereof.

[0090] In at least one embodiment, the antimicrobial agent is selected from the group consisting of phenoxyethanol, benzyl alcohol, phenylethanol, benzoic acid and its salts, piroctone olamine, and mixtures thereof.

[0091] The combination of the invention may be prepared by methods known in the art, for example by mixing the ingredients thereof.

[0092] The blends of the present invention may be prepared by methods known in the art, such as mixing the ingredients thereof.

[0093] The present invention also relates to a preparation comprising:

[0094] (A) at least one compound selected from the group consisting of a compound of formula (I), sorbitan esters, isosorbide esters and glycerol ethers

[0095]

[0096] wherein R is selected from a saturated hydrocarbon chain having 5 to 23 carbon atoms, an unsaturated hydrocarbon chain having 5 to 23 carbon atoms, and mixtures thereof, and

[0097] (B) at least one hydroxamic acid or a salt thereof.

[0098] In one embodiment, the invention relates to a formulation comprising:

[0099] (A) 0.1 to 10% by weight, preferably 0.2 to 3% by weight, particularly preferably 0.3 to 1.5% by weight, based on the total weight of the preparation, of at least one compound selected from the group consisting of compounds of formula (I), sorbitan esters, isosorbide esters and glycerol ethers

[0100]

[0101] wherein R is selected from a saturated hydrocarbon chain having 5 to 23 carbon atoms, an unsaturated hydrocarbon chain having 5 to 23 carbon atoms, and mixtures thereof,

[0102] and

[0103] (B) 0.01 to 1.5% by weight, preferably 0.05 to 0.5% by weight, particularly preferably 0.1 to 0.3% by weight, based on the total weight of the preparation, of at least one hydroxamic acid or a salt thereof.

[0104] In at least one embodiment, the formulation is selected from cosmetic formulations and household cleaning formulations.

[0105] In at least one embodiment, the formulation is selected from the group consisting of: shampoo, shower gel, facial cleanser, facial mask, foam bath, intimate wash, bath oil, cleansing milk, micellar water, makeup remover, cleansing wipes, hair mask, perfume, liquid soap, shaving soap, shaving foam, cleansing foam, day cream, anti-aging cream, body milk, body lotion, body mousse, facial serum, eye cream, sunscreen lotion, sunscreen, face cream, aftershave lotion, shaving cream, hair removal cream, skin whitening gel, tanning cream, anti-acne gel, mascara, foundation, primer, concealer, blush, bronzer, concealer (bb) cream, eyeliner (pencil), night cream, eyebrow gel, highlighter, lip gloss, hand soap, hair oil, nail polish remover, conditioner, hair styling gel, hair styling cream, anti-frizz serum, scalp care, hair dye, split end care solution (split end fluid), deodorant, antiperspirant, baby cream, insect repellent, hand cream, sunscreen gel, foot cream, exfoliator, body scrub, cellulite treatment, bar soap, cuticle lubricant, lip balm, hair care, eye shadow, bath additive, body spray, eau de toilette, mouthwash, toothpaste, lubricating gel, moisturizer, serum, toner, aquasorbet, cream gel, styling mousse, dry shampoo, lipstick, lip gloss, hydroalcoholic gel, body oil, shower gel, illuminator, lip pencil, hair spray, combing cream and sunscreen.

[0106] In at least one embodiment, the formulation is a cosmetic formulation for cleansing hair and / or skin.

[0107] In at least one embodiment, the formulation is a cosmetic formulation, preferably a skin care formulation, more preferably a leave-on skin care formulation.

[0108] In at least one embodiment, the formulation is an aqueous solution.

[0109] In at least one embodiment, the preparation comprises a solvent, in at least one embodiment, the preparation comprises a solvent, wherein the solvent comprises water and / or alcohol. The solvent is useful for providing the compound used in the present invention in liquid form. In at least one embodiment, the solvent is cosmetically acceptable. In at least one embodiment, the preparation comprises at least 10% by weight, preferably at least 20% by weight, more preferably at least 30% by weight, and even more preferably at least 50% by weight of water. Water is useful not only for economic reasons but also because it is cosmetically acceptable. Optionally, the preparation comprises a water miscible or water-soluble solvent, such as a lower alkyl alcohol. In at least one embodiment, the preparation comprises a C1-C5 alkyl monoalcohol, preferably a C2-C3 alkyl monoalcohol. The alcohol that may be present is particularly a lower monoalcohol or polyol with 1 to 4 carbon atoms, such as preferably ethanol or isopropanol, which is commonly used for cosmetic purposes.

[0110] Optionally, the formulation comprises a water-soluble polyol. In at least one embodiment, the water-soluble polyol is a polyol having two or more hydroxyl groups in the molecule. In at least one embodiment, the water-soluble polyol is selected from the group consisting of: diols such as ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, tetramethylene glycol, 2,3-butanediol, pentamethylene glycol, 2-butene-1,4-diol, hexanediol, octanediol; triols such as glycerol, trimethylolpropane, 1,2,6-hexanetriol, etc.; tetraols such as pentaerythritol; pentaols such as xylitol; hexaols such as sorbitol, glycerol, etc. polyol polymers such as diethylene glycol, dipropylene glycol, polyethylene glycol, polypropylene glycol, tetraethylene glycol, diglycerol, polyethylene glycol, triglycerol, tetraglycerol, polyglycerol; glycol alkyl ethers such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monohexyl ether, ethylene glycol mono-2-methylhexyl ether, ethylene glycol isopentyl ether, ethylene glycol benzyl ether, ethylene glycol isopropyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether; glycol alkyl ethers such as diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol butyl ether, diethylene glycol methyl ethyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether, propylene glycol isopropyl ether, dipropylene glycol methyl ether, dipropylene glycol ethyl ether, dipropylene glycol butyl ether; glycol ether esters such as ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether acetate, ethylene glycol diadipic acid ester, ethylene glycol disuccinate, di Ethylene glycol monoethyl ether acetate, diethylene glycol monobutyl ether acetate, propylene glycol monomethyl ether acetate, propylene glycol monoethyl ether acetate, propylene glycol monopropyl ether acetate, propylene glycol monophenyl ether acetate; glycerol monoalkyl ethers, such as wood alcohol, selachyl alcohol, and batyl alcohol; sugar alcohols, such as sorbitol, maltol, maltotriose, mannitol, sucrose, erythritol, glucose, fructose, starch sugar, maltose, xylytose, starch sugar reducing alcohol, glysolid, tetrahydrofurfuryl alcohol, POE tetrahydrofurfuryl alcohol, POP butyl ether, POP POE butyl ether, tripolyoxypropylene glycerol ether, POP glycerol ether, POP glycerol ether phosphoric acid, POP POE pentaerythritol ether, and mixtures thereof.

[0111] In a preferred embodiment, the formulation comprises a solvent selected from the group consisting of water, glycols, ethanol, and mixtures thereof. In a preferred embodiment, the formulation comprises water.

[0112] In a preferred embodiment, the formulation comprises an aqueous, alcoholic or aqueous-alcoholic solvent, wherein the aqueous, alcoholic or aqueous-alcoholic solvent comprises water, ethanol, propanol, isopropanol, 1,2-propylene glycol, 1,3-propylene glycol, isobutanol, butanol, butyl glycol, butyl diethylene glycol, glycerol, or a mixture thereof; preferably, wherein the aqueous, alcoholic or aqueous-alcoholic solvent comprises water, ethanol, propanol, isopropanol, 1,2-propylene glycol, 1,3-propylene glycol, glycerol, or a mixture thereof; more preferably, wherein the aqueous, alcoholic or aqueous-alcoholic solvent comprises water, isopropanol, 1,2-propylene glycol, 1,3-propylene glycol, or a mixture thereof; even more preferably, wherein the aqueous, alcoholic or aqueous-alcoholic solvent consists of water or a mixture of water and an alcohol, wherein the alcohol is selected from isopropanol, 1,2-propylene glycol and 1,3-propylene glycol.

[0113] In at least one embodiment, the preparation contains additives commonly used in cosmetology, pharmacy and dermatology, which are referred to below as adjuvants. In at least one embodiment, the adjuvants are selected from the group consisting of oily substances, emulsifiers, co-emulsifiers, cationic polymers, film formers, superfatting agents, stabilizers, active biological substances, glycerol, preservatives, pearlescent agents, dyes and fragrances, solvents, sunscreens, functional acids and also protein derivatives such as gelatin, collagen hydrolysates, natural or synthetic polypeptides, egg yolk lecithin, lanolin and lanolin derivatives, fatty alcohols, silicones, deodorants, substances with keratolytic and keratolytic effects, enzymes and / or carriers / solvents.

[0114] In at least one embodiment, the formulation comprises water-soluble vitamins and their derivatives, water-soluble amino acids and their salts and / or derivatives, viscosity modifiers, dyes, non-volatile solvents or diluents (water-soluble and water-insoluble), pearlescent aids, thickeners, foam boosters, additional surfactants or nonionic co-surfactants, pediculocides, pH adjusters, fragrances, preservatives, chelating agents, proteins, skin active agents, sunscreens, UV absorbers, vitamins, niacinamide, caffeine, minoxidil, and combinations thereof. In at least one embodiment, the formulation comprises 0 to 5% by weight of vitamins and amino acids based on the total weight of the formulation. The formulation may also contain pigment materials such as inorganic, nitroso, monoazo, diazo, carotenoid, triphenylmethane, triarylmethane, xanthene, quinoline, oxazine, azine, anthraquinone, indigoid, thionindigoid, quinacridone, phthalocyanine, vegetable, natural pigments, including: water-soluble components such as those with CI names. The formulation may contain 0 wt %, preferably 0.0001 wt % to 5 wt % of pigment material.

[0115] In at least one embodiment, the formulation comprises an oily substance, which is any fatty substance that is liquid at room temperature (25°C). In at least one embodiment, the formulation comprises an oily substance selected from the group consisting of: silicone oil, volatile or non-volatile, linear, branched or cyclic, optionally organically modified; phenyl silicones; silicone resins and silicone gums; mineral oils such as paraffin oil or vaseline oil; oils of animal origin such as fully hydrogenated squalene, lanolin; oils of plant origin such as liquid triglycerides, for example sunflower oil, corn oil, soybean oil, rice bran oil, jojoba oil, babassu oil (babusscu oil), pumpkin oil, grapeseed oil, sesame oil, walnut oil, almond oil, macadamia oil, avocado oil, sweet almond oil, sorrel oil, castor oil, caprylic / capric triglyceride, olive oil, peanut oil, rapeseed oil, argan oil, crambe seed oil and coconut oil; synthetic oils such as purcellin oil, isoparaffins, linear and / or branched fatty alcohols and fatty acid esters, preferably guerbet alcohols having 6 to 18, preferably 8 to 10, carbon atoms; linear (C6-C 13 ) fatty acids and straight chain (C6-C 20 ) esters of fatty alcohols; branched (C6-C 13 ) carboxylic acid and straight chain (C6-C 20 ) Esters of fatty alcohols, linear (C6-C 18 ) esters of fatty acids with branched alcohols, in particular 2-ethylhexanol; esters of linear and / or branched fatty acids with polyols (e.g. dimer glycol or trimer glycol) and / or Gilbert alcohols; esters based on (C6-C 10 ) triglycerides of fatty acids; esters such as dioctyl adipate, diisopropyl dimer dilinoleate; propylene glycol / dicaprylate or waxes such as beeswax, paraffin or microcrystalline wax, alone or in combination with a hydrophilic wax, for example cetearyl alcohol; fluorinated and perfluorinated oils; fluorinated silicone oils; mixtures of the aforementioned compounds.

[0116] In at least one embodiment, the formulation contains a nonionic co-emulsifier. In at least one embodiment, the nonionic co-emulsifier is selected from 0 to 30 mol of ethylene oxide and / or 0 to 5 mol of propylene oxide and linear fatty alcohols having 8 to 22 carbon atoms, fatty acids having 12 to 22 carbon atoms, alkylphenols having 8 to 15 carbon atoms in the alkyl group, and adducts of anhydrous sorbitan or sorbitol esters; 0 to 30 mol of ethylene oxide and glycerol adducts (C 12 -C 18) fatty acid monoesters and diesters; glycerol monoesters and diesters and sorbitan monoesters and diesters of saturated and unsaturated fatty acids having 6 to 22 carbon atoms, when appropriate, their ethylene oxide adducts; adducts of 15 to 60 mol of ethylene oxide with castor oil and / or hydrogenated castor oil; polyol esters and in particular polyglycerol esters, such as polyricinoleic acid polyglycerol esters and poly-12-hydroxystearate polyglycerol esters. Similarly suitable are mixtures of compounds from one or more of these classes of substances. Examples of suitable ionizable co-emulsifiers include anionic emulsifiers, such as phosphoric acid monoesters, phosphoric acid diesters or phosphoric acid triesters, and also cationic emulsifiers, such as monoalkyl quaternary ammonium salts, dialkyl quaternary ammonium salts or trialkyl quaternary ammonium salts and their polymer derivatives.

[0117] In at least one embodiment, the formulation comprises a cationic polymer. Suitable cationic polymers include those known under the INCI name "Polyquaternium", in particular polyquaternium-31, polyquaternium-16, polyquaternium-24, polyquaternium-7, polyquaternium-22, polyquaternium-39, polyquaternium-28, polyquaternium-2, polyquaternium-10, polyquaternium-11, and also polyquaternium 37 & mineral oil & PPG trideceth (Salcare SC95), PVP-dimethylaminoethyl methacrylate copolymer, guar gum-hydroxypropyltrimonium hydrochloride, and also calcium alginate and ammonium alginate. In addition, cationic cellulose derivatives; cationic starch; copolymers of diallyl ammonium salts and acrylamide; quaternized vinyl pyrrolidone / vinylimidazole polymers; condensation products of polyethylene glycols and amines; quaternized collagen polypeptides; quaternized wheat polypeptides; polyethyleneimine; cationic silicone polymers, such as amidopolymethylsiloxane; copolymers of adipic acid and dimethylaminohydroxypropyldiethylenetriamine; polyaminopolyamides and cationic chitin derivatives, such as chitosan.

[0118] In at least one embodiment, the formulation comprises a superfatting agent. As superfatting agents, for example, the following substances can be used: polyethoxylated lanolin derivatives, lecithin derivatives, polyol fatty acid esters, monoglycerides, or fatty acid alkanolamides, the latter also acting as foam stabilizers. Available moisturizers include, for example, isopropyl palmitate, glycerol and / or sorbitol.

[0119] In at least one embodiment, the formulation comprises a stabilizer. As stabilizers, for example metal salts of fatty acids, such as magnesium stearate, aluminum stearate and / or zinc stearate can be used.

[0120] In at least one embodiment, the formulation comprises a care additive. The formulation can be blended with conventional ceramides, pseudoceramides, fatty acid N-alkyl polyhydroxyalkylamides, cholesterol, cholesterol fatty acid esters, fatty acids, triglycerides, cerebrosides, phospholipids, panthenol and the like as care additives.

[0121] In at least one embodiment, the formulation comprises an antifungal substance. In at least one embodiment, the antifungal substance is selected from the group consisting of ketoconazole, oxiconazole, bifonazole, butoconazole, cloconazole, clotrimazole, econazole, enriconazole, fenticonazole, isoconazole, miconazole, sukonazole, tioconazole, fluconazole, itraconazole, terconazole, naftifine and terbinafine, zinc pyrithione, piroctone olamine (hydroxypyrrolidone), and combinations thereof. In at least one embodiment, the formulation comprises 0.1% to 1% by weight of the total amount of antifungal substances in the formulation. In at least one embodiment, the formulation comprises pyrithione anti-dandruff particles. For example, 1-hydroxy-2-pyrithione salt is a highly preferred granular anti-dandruff agent. Based on the total weight of the formulation, the concentration of pyrithione anti-dandruff particles can be in the range of 0.1% to 4% by weight, preferably 0.1% to 3% by weight, more preferably 0.3% to 2% by weight. Preferred pyrithione salts include those formed from heavy metals such as zinc, tin, cadmium, magnesium, aluminum and zirconium, preferably zinc, more preferably the zinc salt of 1-hydroxy-2-pyridinethione (referred to as "zinc pyrithione" or "ZPT"), more preferably the 1-hydroxy-2-pyridinethione salt in the form of platelet-like particles. Salts formed from other cations (such as sodium) may also be suitable.

[0122] Functional acids are acidic substances used to impart clinical functions to the skin or hair when applied. Suitable functional acids include alpha-hydroxy acids, beta-hydroxy acids, lactic acid, retinoic acid and the like.

[0123] In at least one embodiment, the formulation comprises an astringent. In at least one embodiment, the astringent is selected from the group consisting of magnesium oxide, aluminum oxide, titanium dioxide, zirconium dioxide, zinc oxide, oxide hydrates, aluminum oxide hydrates (boehmite) and hydroxides, chloride hydrates of calcium, magnesium, aluminum, titanium, zirconium or zinc. In at least one embodiment, the formulation comprises 0.001 wt % to 10 wt %, or 0.01 wt % to 9 wt %, or 0.05 wt % to 8 wt %, or 0.1 wt % to 5 wt % of an astringent.

[0124] In at least one embodiment, the formulation comprises a deodorant. In at least one embodiment, the deodorant is selected from the group consisting of allantoin, bisabolol, and combinations thereof. In at least one embodiment, the formulation comprises 0.001 wt % to 10 wt %, or 0.01 wt % to 9 wt %, or 0.05 wt % to 8 wt %, or 0.1 wt % to 5 wt % of the deodorant.

[0125] In at least one embodiment, the formulation comprises a sunscreen and / or a UV filter. Suitable sunscreens and UV filters are disclosed in WO-2013 / 017262 A1, page 32, line 11 to the end of page 33. In at least one embodiment, the sunscreen and / or UV filter is selected from the group consisting of: 4-aminobenzoic acid, 3-(4'-trimethylammonium)-benzylidene-borane-2-one-methylsulfate, camphorbenzalkonium methylsulfate, 3,3,5-trimethyl-cyclohexyl salicylate, 2-hydroxy-4-methoxybenzophenone, 2-phenylbenzimidazole-5-sulfonic acid and its potassium, sodium and triethanolamine salts, 3,3'-(1,4-phenylene dimethine)-bis-(7,7-dimethyl-2-oxobicyclo[2.2.1]-heptane-1-methanesulfonic acid) and its salts, 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)-1-methylsulfonic acid and its salts. 2-(4-(2-(2-((4-(((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((( 3,3,3-Tetramethyl-1-(trimethylsilyloxy)-disiloxy)-propyl)phenol, 4,4'-[(6-[4-((1,1-dimethylethyl)-amino-carbonyl)phenylamino]-1,3,5-triazine-2,4-yl)diimino]bis-(benzoic acid-2-ethylhexyl ester), 3-benzophenone, 4-benzophenone, 3(4'-methylbenzylidene)-D,L-camphor, 3-benzylidene-camphor, salicylic acid-2-ethylhexyl ester, 4-dimethylaminobenzoic acid-2-ethylhexyl ester, hydroxy-4-methoxy-benzophenone-5-sulfonic acid and its sodium salt, 4-isopropylbenzyl salicylate, methyl sulfate N,N,N-trimethyl- 4-(2-Oxobornyl-3-ylidenemethyl)anilinium, homosalate (INN), oxybenzone (INN), 2-phenylbenzimidazole-5-sulfonic acid and its sodium, potassium and triethanolamine salts, octylmethoxycinnamic acid, 4-methoxycinnamic acid isopentyl ester, p-methoxycinnamic acid isopentyl ester, 2,4,6-triphenylamino-(p-carbon-2'-ethylhexyl-1'-oxy)-1,3,5-triazine (octyl triazone) phenol, 2,2(2H-benzotriazol-2-yl)-4-methyl-6-(2-methyl-3-(1,3,3,3-tetramethyl-1-(trimethylsilyl)oxy)-disiloxane)propyl (drometrizole trisiloxane) benzoic acid, 4,4-((6-(((1,1-dimethylethyl)amino)carbonyl)phenyl)amino)-1,3,5-triazine-2,4-diyl)diimino)bis,bis(2-ethylhexyl)benzoate), 4,4-((6-(((1,1-dimethylethyl)amino)carbonyl)phenyl)amino)-1,3,5-triazine-2,4-diyl)diimino)bis,bis(2-ethylhexyl)ester), 3-(4'-methylbenzylidene)-D,L-camphor (4-methylbenzylidene camphor), benzyl-camphor-sulfonic acid, octyl cyanoacrylate, polyacrylic acid Oleamidomethyl-benzylidene-camphor, 2-ethylhexyl salicylate (octyl salicylate), 4-dimethyl-aminobenzoic acid ethyl-2-hexyl ester (octyl dimethyl PABA), PEG-25 PABA, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid (5-benzophenone) and its sodium salt, 2,2'-methylene-bis-6-(2H-benzotriazol-2-yl)-4-(tetramethyl-butyl)-1,1,3,3-phenol, 2-2'-bis-(1,4-phenylene) 1H-benzimidazole-4,6-disulfonic acid sodium salt, (1,3, 5)-Triazine-2,4-bis((4-(2-ethyl-hexyloxy)-2-hydroxy)-phenyl)-6-(4-methoxyphenyl), 2-ethylhexyl-2-cyano-3,3-diphenyl-2-acrylate, caprylic acid glyceryl ester, di-p-methoxycinnamic acid, p-aminobenzoic acid and its esters, 4-tert-butyl-4'-methoxydibenzoylmethane, 4-(2-β-pyranose glucoseoxy)propoxy-2-hydroxybenzophenone, octyl salicylate, methyl-2,5-diisopropylcinnamic acid, cinoxate, dihydroxy-dimethoxybenzophenone, 2,2'-di Disodium salt of hydroxy-4,4'-dimethoxy-5,5'-disulfobenzophenone, dihydroxybenzophenone, 1,3,4-dimethoxyphenyl-4,4-dimethyl-1,3-pentanedione, 2-ethylhexyl-dimethoxybenzylidene-dioxoimidazolidine propionate, methylene-bis-benzotriazolyl tetramethylbutylphenol, phenyl dibenzimidazole tetrasulfonate, bis-ethylhexyloxyphenol-methoxyphenol-triazine, tetrahydroxybenzophenone, terephthalylidene dicamphor-sulfonic acid, 2,4,6-tris[4,2-ethylhexyloxycarbonyl)phenylamino]-1,3,5-triazine, methyl-bis(trimethylsiloxy)silyl-isoamyltrimethoxycinnamic acid, amyl p-dimethylaminobenzoate, amyl p-dimethylaminobenzoate, 2-ethylhexyl p-dimethylaminobenzoate, isopropyl p-methoxycinnamate / diisopropylcinnamate, 2-ethylhexyl p-methoxycinnamate, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and trihydrate, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium salt, phenyl-benzimidazole sulfonic acid, and combinations thereof. In at least one embodiment, the formulation comprises 0.001% to 10% by weight, preferably 0.05% to 5% by weight, even more preferably 0.1% to 3% by weight, and most preferably 0.05% to 1% by weight of sunscreen and / or UV filter. In at least one embodiment, the formulation comprises a photoprotective substance in an amount of 0.01 to 10% by weight, or 0.1 to 5% by weight, more preferably 0.2 to 2% by weight. Suitable photoprotective substances include, in particular, all photoprotective substances listed in EP1084696A1, which are incorporated herein by reference. In a preferred embodiment, the photoprotective substance is selected from the group consisting of: 2-ethylhexyl 4-methoxycinnamate, methyl methoxycinnamate, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, polyethoxylated p-aminobenzoic acid esters, and combinations thereof. ,

[0126] In at least one embodiment, the formulation comprises an antioxidant. In at least one embodiment, the antioxidant is selected from the group consisting of amino acids, peptides, sugars, imidazoles, carotenoids, carotenes, chlorogenic acid, lipoic acid, thiols, thioglycols, thioN-acetyl esters, thiomethyl esters, thioethyl esters, thiopropyl esters, thiopentyl esters, thiobutyl esters, thiolauryl esters, thiopalmitoyl esters, thiooleyl esters, thiocholesterol esters, thioglycerides, dilaurylthiodipropionate, distearylthiodipropionate, thiodipropionic acid, metal chelators, hydroxy acids, fatty acids, folic acid, vitamin C, tocopherol, vitamin A, stilbene, and derivatives and combinations thereof. In at least one embodiment, the antioxidant is selected from the group consisting of glycerol, histidine, tyrosine, tryptophan, urocannic acid, D,L-carnosine, D-carnosine, L-carnosine, beta-carotene, alpha-carotene, lycopene, dihydrolipoic acid, aurothioglucose, propylthiouracil, thioredoxin, glutathione, cysteine, cystine, cystamine, buthioninsulfoximine, homocysteinesulfoximine, buthioninsulfone, pentathioninesulfoximine, hexanesulfone, thiourea, thiourea, thiourea, thiourea, thiourea, thiourea, thiourea, thiourea, thiourea, thiourea, thiourea, thiourea, thiourea, thiourea, thiourea, thiourea, thiourea, thiourea In at least one embodiment, the antioxidant is selected from the group consisting of vitamin A, vitamin A derivatives, vitamin E, vitamin E derivatives, and combinations thereof. In at least one embodiment, the formulation comprises 0.001 to 10 wt %, preferably 0.05 to 5 wt %, even more preferably 0.1 to 3 wt %, still particularly preferably 0.05 to 1 wt % of antioxidant.

[0127] In at least one embodiment, the preparation comprises a dye or a pigment. In at least one embodiment, the preparation comprises at least one pigment. Suitable dyes and pigments are disclosed in the table across pages 36 to 43 in WO2013 / 017262A1. These can be colored pigments that impart a color effect to the product material or hair, or they can be gloss effect pigments that impart a gloss effect to the product material or hair. The color or gloss effect on the hair is preferably temporary, i.e. they last until the next hair washing and can be removed again by washing the hair with a conventional shampoo. In at least one embodiment, the preparation comprises a total amount of 0.01% to 25% by weight, preferably 5% to 15% by weight of the pigment. In at least one embodiment, the particle size of the pigment is 1 micron to 200 microns, preferably 3 microns to 150 microns, more preferably 10 microns to 100 microns. The pigment is a colorant that is hardly soluble in the application medium and can be inorganic or organic. Inorganic-organic mixed pigments are also possible. Inorganic pigments are preferred. The inorganic pigments are advantageous in that they have excellent resistance to light, weather and temperature. The inorganic pigments may be of natural origin. In at least one embodiment, the inorganic pigments are selected from the group consisting of chalk, ochre, umber, smectite, burnt sienna, graphite, and combinations thereof. The pigments may be white pigments, such as titanium dioxide or zinc oxide, black pigments, such as black iron oxide, colored pigments, such as ultramarine or red iron oxide, luster pigments, metallic effect pigments, pearlescent pigments and fluorescent or phosphorescent pigments, wherein preferably at least one pigment is a colored, non-white pigment. In at least one embodiment, the pigments are selected from the group consisting of metal oxides, hydroxides and oxide hydrates, mixed phase pigments, sulfur-containing silicates, metal sulfides, complex metal cyanides, metal sulfates, chromates and molybdates, and the metal itself (bronze pigments), and combinations thereof. In at least one embodiment, the pigment is selected from the group consisting of titanium dioxide (CI 77891), black iron oxide (CI 77499), yellow iron oxide (CI 77492), red and brown iron oxide (CI 77491), manganese violet (CI 77742), ultramarine (sodium aluminum sulfosilicate, CI 77007, Pigment Blue 29), chromium oxide hydrate (CI 77289), Prussian blue (ferric ferrocyanide, CI 77510), carmine (cochineal), and combinations thereof. In at least one embodiment, the pigment is selected from the group consisting of mica-based pearlescent and colored pigments, which are coated with metal oxides or metal oxychlorides (such as titanium dioxide or bismuth oxychloride) and optionally additional color-imparting substances (such as iron oxides, Prussian blue, ultramarine, carmine, etc.), and wherein the color can be determined by varying the layer thickness. Such pigments, for example, are available under the trade name and Sold by Merck. In at least one embodiment, the pigment is selected from the group consisting of organic pigments such as sepia, gamboge, bone char, Cassel brown, indigo, chlorophyll, and other plant pigments. In at least one embodiment, the pigment is selected from the group consisting of synthetic organic pigments such as azo pigments, anthraquinoids, indigos, dioxazines, quinacridones, phthalocyanines, isoindolinones, perylenes and peronones, metal complexes, basic blues, and diketopyrrolopyrrole pigments.

[0128] In at least one embodiment, the formulation comprises 0.01% to 10% by weight, preferably 0.05% to 5% by weight, of at least one particulate material. Suitable materials are, for example, materials that are solid and in particulate form at room temperature (25°C). In at least one embodiment, the particulate material is selected from the group consisting of: silica, silicates, aluminates, clays, mica, insoluble salts, especially insoluble inorganic metal salts, metal oxides, such as titanium dioxide, minerals and insoluble polymer particles are suitable. The particles may be present in the formulation in an undissolved, preferably stably dispersed form, and may be deposited on the substrate in solid form after being applied to a keratin substrate and evaporating the solvent. A stable dispersion may be achieved by providing a formulation having a sufficiently large yield point to prevent the solid particles from sinking. A suitable gel former may be used in an appropriate amount to establish a sufficient yield point. In at least one embodiment, the particulate material is selected from the group consisting of: silica (silica gel, silicon dioxide) and metal salts, especially inorganic metal salts, wherein silicon dioxide is particularly preferred. The metal salt is, for example, an alkali metal or alkaline earth metal halide, such as sodium chloride or potassium chloride; an alkali metal or alkaline earth metal sulfate, such as sodium sulfate or magnesium sulfate.

[0129] In at least one embodiment, the formulation contains direct dyes. Preferred among the direct dyes are the following compounds, alone or in combination with one another: hydroxyethyl-2-nitro-p-toluidine, 2-hydroxyethylpicric acid, 4-nitrophenyl semicarbazide, tris(4-amino-3-methylphenyl)carbonium chloride (basic violet 2), 1,4-diamino-9,10-anthracenedione (disperse violet 1), 1-(2-hydroxyethyl)amino-2-nitro-4-[di(2-hydroxyethyl)amino]benzene (HC Blue No. 2), 4-[ethyl-(2-hydroxyethyl)amino]-1-[(2-hydroxyethyl)amino]-2-nitrobenzene hydrochloride ( HC Blue No. 12), 1-amino-4-[bis(2-hydroxyethyl)amino]-2-nitrobenzene hydrochloride (HC Red No. 13), 4-amino-1-[(2-hydroxyethyl)amino]-2-nitrobenzene (HC Red No. 3), 4-amino-3-nitrophenol, 4-[(2-hydroxyethyl)amino]-3-nitrophenol, 1-amino-5-chloro-4-[(2,3-dihydroxypropyl)amino]-2-nitrobenzene (HC Red No. 10), 5-chloro-1,4-[bis(2,3-dihydroxypropyl)amino]-2-nitrobenzene (HC Red No. 11 No. 99), 2-chloro-6-ethylamino-4-nitrophenol, 2-amino-6-chloro-4-nitrophenol, 4-[(2-hydroxyethyl)amino]-3-nitro-1-trifluoromethylbenzene (HC Yellow No. 13), 8-amino-2-bromo-5-hydroxy-4-imino-6-{[3-(trimethylammonium)-phenyl]amino}-1(4H)-naphthol chloride (CI56059; Basic Blue No. 99), 1-[(4-aminophenyl)azo]-7-(trimethylammonium)-2-naphthol chloride (CI12250; Basic Brown 16), 1-[(4-amino-2-nitrophenyl)azo]-7-(trimethylammonium)-2-naphthol chloride (Basic Brown No. 17), 2-hydroxy-1-[(2-methoxyphenyl)azo]-7-(trimethylammonium)naphthalene chloride (CI12245; Basic Red No. 76), 3-methyl-1-phenyl-4-{[3-(trimethylammonium)phenyl]azo}pyrazol-5-one chloride (CI12719; Basic Yellow No. 57) and 2,6-diamino-3-[(pyridin-3-yl)azo]pyridine and its salts.Particularly preferred among the aforementioned direct dyes are the following compounds, alone or in combination with one another: hydroxyethyl-2-nitro-p-toluidine, 2-hydroxyethylpicramic acid, 4-nitrophenyl semicarbazide, tris(4-amino-3-methylphenyl)carbonium chloride (basic violet 2), 1,4-diamino-9,10-anthracenedione (disperse violet 1), 1-(2-hydroxyethyl)amino-2-nitro-4-[di(2-hydroxyethyl)amino]benzene (HC Blue No. 2), 4-[ethyl-(2-hydroxyethyl)amino]-1-[(2-hydroxyethyl)amino]-2-nitrobenzene salt Hydrochloride (HC Blue No. 12), 1-amino-4-[bis(2-hydroxyethyl)amino]-2-nitrobenzene hydrochloride (HC Red No. 13), 4-amino-1-[(2-hydroxyethyl)amino]-2-nitrobenzene (HC Red No. 3), 4-amino-3-nitrophenol, 4-[(2-hydroxyethyl)amino]-3-nitrophenol, 1-amino-5-chloro-4-[(2,3-dihydroxypropyl)amino]-2-nitrobenzene (HC Red No. 10), 5-chloro-1,4-[bis(2,3-dihydroxypropyl)-amino]-2-nitrobenzene (HC Red No. 11), 2-chloro-6-ethylamino-4-nitrophenol, 2-amino-6-chloro-4-nitrophenol, 4-[(2-hydroxyethyl)amino]-3-nitro-1-trifluoromethylbenzene (HC Yellow No. 13), 8-amino-2-bromo-5-hydroxy-4-imino-6-{[3-(trimethylammonium)-phenyl]amino}-1(4H)-naphthol chloride (CI56059; Basic Blue No. 99), 1-[(4-aminophenyl)azo]-7-(trimethylammonium)-2-naphthol chloride (CI12250; Basic Blue No. 99), =The total amount of direct dyes in the formulation is 0.01 to 15% by weight, preferably 0.1 to 10% by weight, and most preferably 0.5 to 8% by weight.

[0130] In at least one embodiment, the formulation comprises a conditioning agent. In at least one embodiment, the conditioning agent is a water-insoluble, water-dispersible, non-volatile liquid that forms emulsified liquid particles. In at least one embodiment, the conditioning agent is a silicone (e.g., silicone oil, cationic silicone, silicone gum, high refractive silicone, and silicone resin), an organic conditioning oil (e.g., hydrocarbon oil, polyolefin, and fatty ester), a cationic conditioning surfactant, a high melting point fatty compound, or a combination thereof.

[0131] In at least one embodiment, the conditioning agent is a silicone and the formulation comprises 0.01% to 10%, or 0.1% to 5%, of a silicone conditioning agent by total weight of the formulation. Suitable silicone conditioning agents and optional suspending agents for silicones are described in US-5,104,646. In at least one embodiment, the formulation comprises a silicone gum selected from the group consisting of polydimethylsiloxane, (polydimethylsiloxane) (methylvinylsiloxane) copolymer, poly(dimethylsiloxane) (diphenylsiloxane) (methylvinylsiloxane) copolymer, and mixtures thereof.

[0132] In at least one embodiment, the formulation comprises a terminal amino silicone. "Terminal amino silicone" as defined herein means a silicone comprising one or more amino groups at one or both ends of the silicone backbone. In at least one embodiment, the formulation is substantially free of any silicone compound comprising pendant amino groups. In one embodiment, the formulation is substantially free of any silicone compound that is not a terminal amino silicone. In at least one embodiment, the amino group at at least one end of the silicone backbone of the terminal amino silicone is selected from the group consisting of primary amines, secondary amines, and tertiary amines. In at least one embodiment, the formulation comprises a terminal amino silicone conforming to formula (S):

[0133] (R F ) a G 3-a -Si-(-OSiG2) n -O-SiG 3-a (R F ) a (S)

[0134] in

[0135] G is hydrogen, phenyl, hydroxy or C1-C8 alkyl, preferably methyl;

[0136] a is an integer having a value from 1 to 3, preferably 1;

[0137] b is 0, 1 or 2, preferably 1;

[0138] n is a number from 0 to 1,999;

[0139] R F Is in accordance with the general formula C q H 2q L is a monovalent group, wherein q is an integer having a value from 2 to 8, and L is selected from the following groups: -N(R T )CH2-CH2-N(R T )2;-N(R T )2;-N(R T )3A- ;-N(R T )CH2-CH2-NR T H2A - ; where R T A is hydrogen, phenyl, benzyl or a saturated hydrocarbon group, preferably an alkyl group having 1 to 20 carbon atoms; - It is a halide ion.

[0140] In at least one embodiment, the terminal amino silicone corresponding to formula (S) has a=1, q=3, G=methyl, n is 1000 to 2500, or 1500 to 1700, and L is -N(CH3)2. Suitable terminal amino silicones corresponding to formula (S) have a=0, G=methyl, n is 100 to 1500, or 200 to 800, and L is selected from the following groups: -N(R T )CH2-CH2-N(R T )2;-N(R T )2;-N(R T )3A - ;-N(R T )CH2-CH2-NR T H2A - ; where R T A is hydrogen, phenyl, benzyl or a saturated hydrocarbon group, preferably an alkyl group having 1 to 20 carbon atoms; - is a halide ion, or L is -NH2. In at least one embodiment, the terminal amino silicone is selected from the group consisting of bisaminomethyl polydimethylsiloxane, bisaminoethyl polydimethylsiloxane, bisaminopropyl polydimethylsiloxane, bis-aminobutyl polydimethylsiloxane, and mixtures thereof. In one embodiment, the viscosity of the terminal amino silicone is 1,000 to 30,000 cPs, or 5,000 to 20,000 cPs when measured at 25°C. In at least one embodiment, the formulation comprises 0.1% to 20%, or 0.5% to 10%, or 1% to 6% of the terminal amino silicone by total weight of the formulation.

[0141] In at least one embodiment, the formulation comprises a high melting point fatty compound. The high melting point fatty compound has a melting point of 25°C or higher. In at least one embodiment, the high melting point fatty compound is selected from the group consisting of: fatty alcohols, fatty acids, fatty alcohol derivatives, fatty acid derivatives, and mixtures thereof. Non-limiting examples of high melting point compounds are found in the International Cosmetic Ingredient Dictionary, Fifth Edition, 1993 and the CTFA Cosmetic Ingredient Handbook, Second Edition, 1992. The formulation may comprise 0.1% to 40%, or 1% to 30%, or 1.5% to 16%, or 1.5% to 8% of a high melting point fatty compound by the total weight of the formulation. This is advantageous in view of providing improved conditioning benefits, such as a smooth feel during application to wet hair, a soft and moisturizing feel on dry hair. In at least one embodiment, the fatty alcohol is selected from the group consisting of: cetyl alcohol, stearyl alcohol, behenyl alcohol, and mixtures thereof. In at least one embodiment, the formulation comprises a linear fatty alcohol, wherein the linear fatty alcohol is contained in a lamellar gel matrix. The lamellar gel matrix is ​​suitable for providing various conditioning benefits, such as a smooth feel during application to wet hair and a soft and moisturized feel on dry hair. The linear fatty alcohol may contain 8 to 24 carbon atoms. In one embodiment, the linear fatty alcohol is selected from the group consisting of cetyl alcohol, stearyl alcohol, and mixtures thereof. In one embodiment, the weight ratio of total linear fatty alcohol to terminal amino silicone is from 0.5:1 to 10:1, or from 1:1 to 5:1, or from 2.4:1 to 2.7:1.

[0142] In at least one embodiment, the lamellar gel matrix comprises a cationic conditioning surfactant and a high melting point fatty compound. In view of providing a lamellar gel matrix, the cationic conditioning surfactant and the high melting point fatty compound are contained at a level such that the weight ratio of the cationic surfactant to the high melting point fatty compound is in the range of 1:1 to 1:10, or 1:1 to 1:6.

[0143] In at least one embodiment, the formulation comprises a cationic conditioning surfactant. In at least one embodiment, the formulation comprises 0.05% to 3.0%, or 0.075% to 2.0%, or 0.1% to 1.0% of a cationic conditioning surfactant by total weight of the formulation. In at least one embodiment, the cationic conditioning surfactant is contained in a lamellar gel matrix. In other words, the formulation comprises a lamellar gel matrix and the lamellar gel matrix comprises a cationic conditioning surfactant. In one embodiment, the cationic conditioning surfactant is according to formula (C):

[0144]

[0145] Among them, R 71 , R 72 , R 73 and R 74 At least one of the following is selected from an aliphatic group having 8 to 30 carbon atoms, an aromatic group, an alkoxy group, a polyoxyalkylene group, an alkylamido group, a hydroxyalkyl group, an aryl group or an alkylaryl group having up to 22 carbon atoms; the remaining R 71 , R 72 , R 73 and R 74 independently selected from the group consisting of an aliphatic group of 1 to 22 carbon atoms, an aromatic group, an alkoxy group, a polyoxyalkylene group, an alkylamido group, a hydroxyalkyl group, an aryl group or an alkylaryl group having up to 22 carbon atoms;

[0146] X is selected from the group consisting of halogen, acetate, citrate, lactate, glycolate, phosphate, nitrate, sulfonate, sulfate, alkyl sulfate, alkyl sulfonate, and combinations thereof.

[0147] In at least one embodiment, the cationic conditioning surfactant is selected from the group consisting of behentrimonium chloride, behentrimonium methylsulfate, or behentrimonium ethylsulfate, and steartrimonium chloride, steartrimonium methylsulfate, or steartrimonium ethylsulfate. It is believed that the longer alkyl groups provide improved smoothness and soft feel on wet and dry hair compared to cationic surfactants with shorter alkyl groups. It is also believed that such cationic surfactants can provide reduced irritation compared to those with shorter alkyl groups.

[0148] In at least one embodiment, the cationic surfactant is a di-long alkyl quaternary ammonium salt selected from the group consisting of dialkyl (C14-C18) dimethyl ammonium chloride, ditallow alkyl dimethyl ammonium chloride, dihydrogenated tallow alkyl dimethyl ammonium chloride, distearyl dimethyl ammonium chloride, dicetyl dimethyl ammonium chloride, and mixtures thereof.

[0149] In at least one embodiment, the cationic surfactant is a tertiary amidoamine with an alkyl group of 12 to 22 carbons. The tertiary amidoamine can be selected from the group consisting of stearyl amidopropyl dimethylamine, stearyl amidopropyl diethylamine, stearyl amidoethyl diethylamine, stearyl amidoethyl dimethylamine, palmitamidopropyl dimethylamine, palmitamidopropyl diethylamine, palmitamidoethyl diethylamine, palmitamidoethyl dimethylamine, behenamidopropyl dimethylamine, behenamidopropyl diethylamine, behenamidoethyl diethylamine, behenamidoethyl dimethylamine, arachidyl amidopropyl dimethylamine, arachidyl amidopropyl diethylamine, arachidyl amidoethyl diethylamine and arachidyl amidoethyl dimethylamine, diethylaminoethyl stearamide, and mixtures thereof. The tertiary amidoamine can be used in combination with an acid. Acid is typically used as a salt-forming anion. In one embodiment, the acid is selected from the group consisting of lactic acid, malic acid, hydrochloric acid, 1-glutamic acid, acetic acid, citric acid, and mixtures thereof.

[0150] In at least one embodiment, the cationic surfactant is selected from the group consisting of cetyltrimethylammonium chloride (CTAC), stearyltrimethylammonium chloride (STAC), behentrimethylammonium methylsulfate, stearamidopropyldimethylamine (SAPDMA), distearyldimethylammonium chloride, and mixtures thereof.

[0151] In at least one embodiment, the formulation comprises a surfactant system. In at least one embodiment, the surfactant system comprises a surfactant selected from the group consisting of anionic surfactants, cationic surfactants, nonionic surfactants, zwitterionic surfactants and / or amphoteric surfactants. In at least one embodiment, the formulation comprises a total amount of surfactants in an amount of 0.01 wt % to 70 wt %, 0.1 wt % to 40 %, 1 wt % to 30 %, 2 wt % to 20 wt %.

[0152] In at least one embodiment, the formulation comprises an anionic surfactant. In at least one embodiment, the anionic surfactant is selected from the group consisting of: (C 10 -C 20)-alkyl and alkylene carboxylates, alkyl ether carboxylates, fatty alcohol sulfates, fatty alcohol ether sulfates, alkylamide sulfates and sulfonates, fatty acid alkylamide polyglycol ether sulfates, alkane sulfonates and hydroxyalkane sulfonates, olefin sulfonates, acyl esters of isethionates, α-sulfo fatty acid esters, alkylbenzene sulfonates, alkylphenol glycol ether sulfonates, sulfosuccinates, sulfosuccinic acid monoesters and diesters, fatty alcohol ether phosphates, protein / fatty acid condensation products, alkyl monoglyceride sulfates and sulfonates, alkylglyceride ether sulfonates, fatty acid methyl taurates, fatty acid sarcosinates, sulforicinoleates, acyl glutamates, and mixtures thereof. Anionic surfactants (and mixtures thereof) can be used in the form of their water-soluble or water-dispersible salts, for example, sodium, potassium, magnesium, ammonium, monoethanolammonium, diethanolammonium and triethanolammonium and similar alkylammonium salts. In at least one embodiment, the anionic surfactant is a salt of an anionic surfactant containing 12 to 14 carbon atoms. In at least one embodiment, the anionic surfactant is selected from the group consisting of sodium lauryl sulfate, sodium laureth sulfate, sodium tridecyl sulfate, sodium trideceth sulfate, sodium myristyl sulfate, sodium myreth sulfate, and mixtures thereof.

[0153] In at least one embodiment, the formulation comprises an acyl glycinate surfactant. In at least one embodiment, the acyl glycinate surfactant conforms to formula (Y):

[0154]

[0155] R 1a is a straight-chain or branched saturated alkyl radical having 6 to 30, preferably 8 to 22, particularly preferably 8 to 18 carbon atoms or is a straight-chain or branched, monounsaturated or polyunsaturated alkenyl radical having 6 to 30, preferably 8 to 22, particularly preferably 12 to 18 carbon atoms, and

[0156] Q a + It is a cation.

[0157] In at least one embodiment, Q a + Selected from the group consisting of: Li + 、Na + , K + Mg ++ , Ca ++ 、Al +++ NH4 +, monoalkylammonium ions, dialkylammonium ions, trialkylammonium ions and tetraalkylammonium ions, or combinations thereof. In at least one embodiment, the acyl glycinate surfactant is selected from sodium cocoyl glycinate and potassium cocoyl glycinate. In at least one embodiment, the acyl glycinate surfactant is selected from the group consisting of: 12 Alkyl or C 14 In at least one embodiment, the acyl glycinate surfactant is selected from the group consisting of: 16 Alkyl or C 18 Those of alkyl.

[0158] In at least one embodiment, the formulation comprises a glutamate surfactant or a salt thereof corresponding to formula (Z):

[0159]

[0160] in:

[0161] R' is HOOC-CH2-CH2- or M + -OOC-CH2-CH2-, where M + It is a cation;

[0162] R is a straight chain or branched, saturated alkyl group having 6 to 30, preferably 8 to 22, more preferably 8 to 18 carbon atoms or a straight chain or branched, monounsaturated or polyunsaturated alkenyl group having 6 to 30, preferably 8 to 22, more preferably 12 to 18 carbon atoms. + is a metal cation. In at least one embodiment, M + Selected from the group consisting of: Li + 、Na + , K + Mg ++ , Ca ++ 、Al +++ NH4 + , monoalkylammonium ions, dialkylammonium ions, trialkylammonium ions and tetraalkylammonium ions, or combinations thereof.

[0163] In at least one embodiment, the glutamate surfactant is selected from sodium cocoyl glutamate and potassium cocoyl glutamate. In at least one embodiment, the glutamate surfactant is selected from the group consisting of: 12 Alkyl or C 14 In at least one embodiment, the glutamate surfactant is selected from the group consisting of: 16 Alkyl or C 18 Those of alkyl.

[0164] In at least one embodiment, the formulation comprises 0.01% to 30% by weight, preferably 1% to 25% by weight, more preferably 5% to 20% by weight, particularly preferably 12% to 18% by weight of anionic surfactant.

[0165] In at least one embodiment, the formulation comprises a nonionic surfactant. In at least one embodiment, the nonionic surfactant has an HLB (hydrophile lipophile balance) greater than 12. Optionally, the nonionic surfactant is selected from the group consisting of: ethoxylated or ethoxylated / propoxylated fatty alcohols with a fatty chain of 12 to 22 carbon atoms, ethoxylated sterols such as stearyl alcohol or lauryl alcohol (EO-7), PEG-16 soy sterol or PEG-10 soy sterol, polyoxyethylene polyoxypropylene block polymers (poloxamers), and mixtures thereof.

[0166] In at least one embodiment, the nonionic surfactant is selected from the group consisting of ethoxylated fatty alcohols, fatty acids, fatty acid glycerides or alkylphenols, in particular 2 to 30 mol of ethylene oxide and / or 1 to 5 mol of propylene oxide to C8- to C 22 - fatty alcohol, up to C 12 - to C 22 - addition products of fatty acids or of alkylphenols having 8 to 15 carbon atoms in the alkyl radical, of addition products of 1 to 30 mol of ethylene oxide onto glycerol 12 - to C 22 - mono- and diesters of fatty acids, addition products of 5 to 60 mol of ethylene oxide onto castor oil or onto hydrogenated castor oil, sugar esters of fatty acids, in particular sucrose with one or two C8- to C 22 - Esters of fatty acids, INCI: sucrose cocoate, sucrose dilaurate, sucrose distearate, sucrose laurate, sucrose myristate, sucrose oleate, sucrose palmitate, sucrose ricinoleate, sucrose stearate, sorbitan with one, two or three C8- to C 22 - fatty acid esters and having a degree of ethoxylation of 4 to 20, polyglyceryl fatty acid esters, in particular one, two or more C8- to C 22 - polyglyceryl fatty acid esters of fatty acids and polyglycerol having preferably 2 to 20 glyceryl units, alkyl glucosides, alkyl oligoglucosides and alkyl polyglucosides having C8 to C 22 - alkyl groups, for example decyl glucoside or lauryl glucoside, and mixtures thereof.

[0167] In at least one embodiment, the nonionic surfactant is selected from the group consisting of fatty alcohol ethoxylates (alkyl polyethylene glycols), alkylphenol polyethylene glycols, alkylthiol polyethylene glycols, fatty amine ethoxylates (alkylamino polyethylene glycols), fatty acid ethoxylates (acyl polyethylene glycols), polypropylene glycol ethoxylates (e.g. ), fatty acid alkyl alcohol amides (fatty acid amide polyethylene glycol), N-alkyl, N-alkoxy-polyhydroxy-fatty acid amides, sucrose esters, sorbitan esters, polyglycol ethers, and mixtures thereof.

[0168] In at least one embodiment, the formulation comprises a fatty N-methyl-N-glucamide surfactant, wherein the fatty N-methyl-N-glucamide surfactant conforms to formula (X):

[0169]

[0170] Wherein, R is selected from saturated or unsaturated hydrocarbon chains having 5 to 23 carbon atoms. Preferably, R in formula (X) is selected from saturated or unsaturated hydrocarbon chains having 7 to 17 carbon atoms. Also preferably, the RC=O residue in formula (X) is derived from caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, coconut fatty acid, or a mixture thereof. Also preferably, the RC=O residue in formula (X) is derived from 9-decenoic acid, 9-dodecenoic acid, or a mixture thereof.

[0171] Particularly preferred N-methyl-N-acylglucosamines of formula (X) are capryloyl / hexanoyl methylglucosamide, lauroyl / myristoyl methylglucosamide, cocoyl methylglucosamide, oleoyl methylglucosamide, or mixtures thereof. Such N-methyl-N-acylglucosamines are commercially available from Clariant ( Clear, Plus, Flex, Care, Sense).

[0172] Also particularly preferred N-methyl-N-acylglucamines of formula (X) are N-9-decenoyl-N-methylglucamine, N-9-dodecenoyl-N-methylglucamine, or mixtures thereof.

[0173] In at least one embodiment, the formulation comprises from 1 wt% to 20 wt%, preferably from 2 wt% to 10 wt%, more preferably from 3 wt% to 7 wt% of a nonionic surfactant.

[0174] In at least one embodiment, the amphoteric surfactant is selected from the group consisting of: N-(C-2-ylidene)-2-ylidene ...12 -C 18 )-alkyl-β-iminodipropionate and N-(C 12 -C 18 )-alkyl-β-aminopropionate; N-acylaminoalkyl-N,N-dimethylacetyl betaine, preferably N-(C8-C 18 )-Acylaminopropyl-N,N-dimethylacetyl betaine, (C 12 -C 18 )-alkyl-dimethyl-sulfopropyl betaine, imidazoline-based amphoteric surfactants (e.g. ), preferably the sodium salt of 1-(β-carboxymethyloxyethyl)-1-(carboxymethyl)-2-laurylimidazolinium; amine oxides, such as (C 12 -C 18 )-alkyl dimethylamine oxides, fatty acid acylamino alkyl dimethylamine oxides, and mixtures thereof.

[0175] In at least one embodiment, the formulation comprises a betaine surfactant. Optionally, the betaine surfactant is selected from C8- to C 18 -alkyl betaine. In at least one embodiment, the betaine surfactant is selected from the group consisting of: coconut dimethyl carboxymethyl betaine, lauryl dimethyl carboxymethyl betaine, lauryl dimethyl alpha carboxyethyl betaine, cetyl dimethyl carboxymethyl betaine, oleyl dimethyl gamma carboxypropyl betaine and lauryl bis (2-hydroxypropyl) alpha carboxyethyl betaine, and combinations thereof. Optionally, the betaine surfactant is selected from C8- to C 18 -sulfobetaine. In at least one embodiment, the betaine surfactant is selected from the group consisting of: cocodimethyl sulfopropyl betaine, stearyl dimethyl sulfopropyl betaine, lauryl dimethyl sulfoethyl betaine, lauryl bis (2-hydroxyethyl) sulfopropyl betaine, and combinations thereof. Optionally, the betaine surfactant is selected from carboxyl derivatives of imidazole, C8- to C 18 -Alkyl dimethyl ammonium acetate, C8- to C 18 -alkyldimethylcarbonylmethylammonium salts, and C8- to C 18 - fatty acid alkyl amido betaine, and mixtures thereof. Optionally, C8- to C 18 - Fatty acid alkyl amido betaine is selected from coconut fatty acid amidopropyl betaine, N-coconut fatty acid amidoethyl-N-[2-(carboxymethoxy)ethyl]glycerol (CTFA name: Cocoamphocarboxyglycinate), and mixtures thereof.

[0176] In at least one embodiment, the formulation comprises 0.5% to 20%, preferably 1% to 10% by weight of amphoteric surfactant.

[0177] In at least one embodiment, the formulation comprises a surfactant system. In at least one embodiment, the surfactant system comprises at least one surfactant selected from the group consisting of lauryl sulfate, laureth sulfate, cocoamido-propyl betaine, sodium cocoyl glutamate, lauroamphoacetate, and mixtures thereof. In at least one embodiment, the surfactant system comprises sodium laureth sulfate, sodium lauryl sulfate, and optionally cocoamidopropyl betaine. In at least one embodiment, the surfactant system comprises sodium laureth sulfate, potassium cocoyl glutamate, and cocoamidopropyl betaine.

[0178] In at least one embodiment, the formulation further comprises a hair-fixing polymer. In at least one embodiment, the hair-fixing polymer is selected from the group consisting of amphoteric hair-fixing polymers, zwitterionic hair-fixing polymers, anionic hair-fixing polymers, nonionic hair-fixing polymers, cationic hair-fixing polymers, and mixtures thereof. In at least one embodiment, the formulation comprises 0.01% to 20%, or 0.01% to 16%, or 0.01% to 10%, or 1% to 8%, or 2% to 6% of a hair-fixing polymer. Suitable hair-fixing polymers are disclosed, for example, in WO2018 / 002100 (pp. 55-63).

[0179] In at least one embodiment, the formulation has a viscosity of 0 cPs to 20,000 cPs. In at least one embodiment, the formulation has a viscosity of 0.1 cPs to 10,000 cPs, or 1 cPs to 5,000 cPs, or 5 cPs to 3,500 cPs.

[0180] The viscosity measurement conditions are defined in the above definition section. Viscosity can be important for anti-drip reasons. Dripping can be inconvenient for the user. In addition, more viscous formulations can be used for measured dispersion. In at least one embodiment, the formulation has a viscosity of 0 cPs to 1,000 cPs. When the formulation is in the form of a cleanser, this viscosity range is advantageous in view of the need for the ability to be dispersed on the skin and rinsed off.

[0181] In at least one embodiment, the formulation further comprises a viscosity-modifying substance. The viscosity-modifying substance is preferably a thickening polymer.

[0182] In at least one embodiment, the thickening polymer is an acrylamidomethylpropane sulfonic acid based polymer. These polymers exhibit good thickening properties even at pH values ​​below 7. Particularly preferably, the thickening polymer is selected from the group consisting of homopolymers or copolymers of acrylamidomethylpropanesulfonic acid and its salts. Of the polymers just mentioned, preference is given to polymers having at least 20 mol % of units based on acrylamidomethylpropanesulfonic acid and / or its salts, and particular preference is given to polymers having at least 50 mol % of units based on acrylamidomethylpropanesulfonic acid and / or its salts, the molar numbers relating in each case to the entire polymer. In the case of copolymers, in addition to the structural units based on acrylamidomethylpropanesulfonic acid and / or its salts, preferably one or more structural units based on the following comonomers are present in the copolymer: acrylic acid; methacrylic acid; acrylamide; dimethylacrylamide; vinylpyrrolidone (VP); hydroxyethyl acrylate; hydroxyethyl methacrylate; ethoxylated alcohol RO-(CH2CH2O) m H, wherein R is an alkyl group having 12 to 30 carbon atoms and m is a number from 3 to 30, and CH2=CH-COO-(CH2CH2-COO) n X, wherein n is a number from 0 to 10, and X is a counterion and is preferably H + 、Na + and / or NH4 + The polymers selected from the group consisting of homopolymers or copolymers of acrylamidomethylpropanesulfonic acid and its salts may be crosslinked or uncrosslinked. In the case of crosslinking, they contain structural units based on monomers having 2 or more olefinic double bonds. In the case of crosslinking, preferably 0.1 to 10 mol-% of such structural units, based on the entire polymer, are present in the homopolymer or copolymer. If one or more structural units based on acrylamidomethylpropanesulfonic acid and / or its salts in the homopolymer or copolymer of acrylamidomethylpropanesulfonic acid and / or its salts have one or more structural units that are not H + The other counterions are preferably selected from Na + and NH4 + Suitable polymers are mentioned in the published documents, including EP-0816403, EP-1069142, EP-1116733 and DE-10 2009 014877 (Clariant), EP-1347736 (L'Oréal) or EP-1496081 (Seppic). Examples include: AVC (ammonium acryloyldimethyltaurate / VP copolymer), AVS (sodium acryloyldimethyl taurate / VP cross-linked polymer), TAC (ammonium acryloyldimethyltaurate carboxyethyl acrylate crosspolymer), AMPS (ammonium polyacryloyl dimethyl taurate), HMB (Ammonium Acryloyldimethyltaurate / Beheneth-25 Methacrylate Crosspolymer), BLV (Ammonium Acryloyldimethyltaurate / Beheneth-25 Methacrylate Crosspolymer), HMS (Ammonium Acryloyldimethyltaurate / Steareth-25 Methacrylate Crosspolymer), SNC (ammonium acryloyldimethyltaurate / stearyl ether-8 methacrylate copolymer), LNC (Ammonium Acryloyldimethyltaurate / Laureth-7 Methacrylate Copolymer) or EMT 10 (Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer), 305.

[0183] In at least one embodiment, the thickening polymer is selected from the group consisting of: copolymers of at least one first monomer type selected from acrylic acid and methacrylic acid and at least one second monomer type selected from esters of acrylic acid and ethoxylated fatty alcohols; crosslinked polyacrylic acid; at least one first monomer type selected from acrylic acid and methacrylic acid and at least one second monomer type selected from esters of acrylic acid and ethoxylated fatty alcohols; 10 - to C 30 -alcohol; a crosslinked copolymer of at least one first monomer type selected from acrylic acid and methacrylic acid and at least one second monomer type selected from esters of itaconic acid and ethoxylated fatty alcohols; a copolymer of at least one first monomer type selected from acrylic acid and methacrylic acid, selected from itaconic acid and ethoxylated C 10 - to C 30 -alcohol esters and a third monomer type selected from C1- to C4-aminoalkyl acrylates; copolymers of two or more monomers selected from acrylic acid, methacrylic acid, acrylates and methacrylates; copolymers of vinyl pyrrolidone and ammonium acryloyldimethyltaurate; copolymers of ammonium acryloyldimethyltaurate and a monomer selected from esters of methacrylic acid with ethoxylated fatty alcohols; hydroxyethylcellulose; hydroxypropylcellulose; hydroxypropyl guar gum; glyceryl polyacrylate; glyceryl polymethacrylate; copolymers of at least one C2-, C3- or C4-olefin and styrene; polyurethane; hydroxypropyl starch phosphate; polyacrylamide; copolymers of methyl vinyl ether and maleic anhydride crosslinked with decadiene; carob seed meal; guar gum; xanthan gum; dehydrogenated xanthan gum; carrageenan; karaya gum; hydrolyzed corn starch; copolymers of polyethylene oxide, fatty alcohols and saturated methylene diphenyl diisocyanate (e.g., PEG-150 / stearyl alcohol / SMDI copolymer); and mixtures thereof.

[0184] In at least one embodiment, the formulation has a pH value of 2.0 to 12.0, preferably 3.0 to 9.0, more preferably 4.5 to 7.5. By changing the pH value, the formulation can be adapted to different applications.

[0185] In at least one embodiment, the formulation comprises an alkalizing agent or a pH adjusting agent. In at least one embodiment, ammonia or caustic soda are suitable, but water-soluble physiologically tolerable salts of organic and inorganic bases are also contemplated. Optionally, the pH adjusting agent is selected from ammonium bicarbonate, ammonia, monoethanolamine, ammonium carbonate. In at least one embodiment, the alkalizing agent or pH adjusting agent is selected from the group consisting of: 2-amino-2-methyl-1-propanol, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-ethyl-1,3-propanediol, tris(hydroxymethyl)-aminomethane, 2-amino-1-butanol, tris(2-hydroxypropyl)-amine, 2,2-iminobisethanol, lysine, iminourea (guanidine carbonate), tetrahydro-1,4-oxazine, 2-amino-5-guanidine-pentanoic acid, 2-aminoethanesulfonic acid, diethanolamine, triethanolamine, N-methylethanolamine, isopropanolamine, diisopropanolamine, triisopropanolamine, glucosamine, sodium hydroxide, potassium hydroxide, lithium hydroxide, magnesium oxide, and mixtures thereof.

[0186] To establish an acidic pH, an acid may be included. In at least one embodiment, the formulation comprises an acid selected from the group consisting of hydrochloric acid, phosphoric acid, acetic acid, formic acid, sulfuric acid, citric acid, and mixtures thereof. Citric acid is most preferred because it has high consumer acceptance. In at least one embodiment, the acidic pH is adjusted with a buffer such as a phosphate buffer, a TRIS buffer, or a citric acid buffer. The buffer may be used alone or in combination with an acid.

[0187] In at least one embodiment, the preparation is in liquid form. In an optional embodiment, the preparation is in solid form. Optionally, the preparation is in powdered or granular form. This is advantageous because there is no need to transport liquids, which are typically heavy and long distances, which has economic and environmental benefits. Solid forms can be achieved by spray drying the preparation or using a rotary evaporator. The preparation can be converted into a liquid form after the preparation is transported, for example by adding water.

[0188] In at least one embodiment, the formulation is a household cleaning formulation.

[0189] In at least one embodiment, the formulation is a hand washing formulation. In at least one embodiment, the hand washing formulation comprises an anionic surfactant. In at least one embodiment, the hand washing formulation comprises 5% to 25% by weight of an anionic surfactant. In at least one embodiment, the hand washing formulation comprises a surfactant system comprising at least one anionic surfactant and an additional surfactant selected from a nonionic surfactant, an amphoteric surfactant or a zwitterionic surfactant, and combinations thereof.

[0190] Preferably, the hand washing formulation comprises cocamidopropyl betaine or an amine oxide. Preferably, the amine oxide is laurylamine oxide, cocoylamine oxide, or a combination thereof. In at least one embodiment, the pH value of the hand washing formulation is between pH 5.0 and pH 10, preferably between pH 5.5 and pH 9.0. In the case of a hand washing formulation comprising an amine oxide, the hand washing formulation preferably has a pH between pH 7.5 and pH 9.5, most preferably between pH 8.0 and pH 9.0.

[0191] In at least one embodiment, the formulation is a hard surface cleaner. In at least one embodiment, the hard surface cleaner comprises an anionic surfactant. In at least one embodiment, the hard surface cleaner comprises 1 wt % to 10 wt % of anionic surfactant. In at least one embodiment, the hard surface cleaner comprises a nonionic surfactant. In at least one embodiment, the hard surface cleaner comprises 1 wt % to 10 wt % of a nonionic surfactant. In at least one embodiment, the hard surface cleaner comprises a surfactant system comprising at least one anionic surfactant and an additional surfactant selected from nonionic surfactants, amphoteric surfactants and zwitterionic surfactants, and combinations thereof. Preferably, the hard surface cleaner comprises linear alkylbenzene sulfonate / ester and fatty alcohol ethoxylate. In at least one embodiment, the pH value of the hard surface cleaner is between pH 5.0 and pH 11, preferably between pH 6.0 and pH 9.0.

[0192] In at least one embodiment, the formulation is a liquid laundry detergent formulation comprising one or more surfactants. Preferably, the one or more surfactants of the liquid laundry detergent formulation are selected from anionic, nonionic, cationic and zwitterionic surfactants, and more preferably selected from anionic, nonionic and zwitterionic surfactants.

[0193] Anionic surfactants

[0194] In at least one embodiment, the formulation comprises an anionic surfactant. Anionic surfactants are particularly useful in cleaning formulations, such as household cleaning formulations. Preferred anionic surfactants are alkyl sulfonates and alkyl ether sulfates. Preferred alkyl sulfonates are alkyl benzene sulfonates, particularly those having C8-C 15 , preferably C 12 -C 14 The linear alkylbenzene sulfonate (LAS) of alkyl chain length of 1000 Å. Possible counterions for the concentrated alkaline liquid are ammonium ions, such as those produced by neutralizing the alkylbenzene sulfonic acid with one or more ethanolamines, such as monoethanolamine (MEA) and triethanolamine (TEA), or alternatively alkali metals, such as those produced by neutralizing the alkylbenzene sulfonic acid with an alkali metal hydroxide. Preferred alkyl ether sulfates (AES) are alkyl polyethoxylate sulfate anionic surfactants.

[0195] Nonionic surfactants

[0196] In at least one embodiment, the formulation comprises a nonionic surfactant. Nonionic surfactants include primary and secondary alcohol ethoxylates, particularly C8-C60 ethoxylated with an average of 1 to 20 moles of ethylene oxide per mole of alcohol. 20 Aliphatic alcohols, and more particularly C ethoxylated with an average of 1 to 10 mol of ethylene oxide per mol of alcohol 10 -C 15 Primary and secondary aliphatic alcohols. Non-ethoxylated nonionic surfactants include alkyl polyglycosides, glycerol monoethers and polyhydroxyamides (glucamides). Mixtures of nonionic surfactants may be used.

[0197] When included therein, household cleaning formulations, especially liquid laundry detergent formulations, preferably contain 0.2% to 40%, more preferably 1% to 20% by weight of nonionic surfactants such as alcohol ethoxylates, nonylphenol ethoxylates, alkyl polyglycosides, alkyl dimethylamine oxides, ethoxylated fatty acid monoethanolamides, fatty acid monoethanolamides, polyhydroxyalkyl fatty acid amides, N-acyl-N-alkyl derivatives of glucosamine ("glucamides"), or combinations thereof. Nonionic surfactants that can be used include primary and secondary alcohol ethoxylates, especially C8-C6 ethoxylated alcohols ethoxylated with an average of 1 to 35 moles of ethylene oxide per mole of alcohol. 20 Aliphatic alcohols, and more particularly C ethoxylated with an average of 1 to 10 mol of ethylene oxide per mol of alcohol 10 -C 15 Primary and secondary aliphatic alcohols.

[0198] Zwitterionic surfactants

[0199] In at least one embodiment, the formulation comprises a zwitterionic surfactant. The liquid laundry detergent formulation may comprise a zwitterionic surfactant, such as an amine oxide or a betaine, preferably in an amount of up to 10 wt %, based on the total weight of the liquid laundry detergent formulation. The betaine may be an alkyl dimethyl betaine or an alkyl amido betaine, wherein the alkyl group has a C 12 -C 18 chain.

[0200] Additional surfactants

[0201] In at least one embodiment, the liquid laundry detergent formulation comprises a surfactant selected from the group consisting of anionic surfactants, nonionic surfactants, and mixtures thereof; preferably, the surfactant is selected from the group consisting of linear alkylbenzene sulfonates, alkyl ether sulfates, nonionic surfactants, amine oxides and betaines; and more preferably selected from the group consisting of linear alkylbenzene sulfonates, alkyl ether sulfates and nonionic surfactants. Other surfactants other than the preferred LAS, AES and nonionic surfactants may also be added. Although less preferred, alkyl sulfate surfactants, particularly non-ethoxylated C 12 -C 15 Primary and secondary alkyl sulfates. Soaps may also be used. The level of soap is preferably less than 10 wt%.

[0202] Preferably, the one or more surfactants in the liquid laundry detergent formulation are present in an amount of at least 5% by weight, preferably from 5 to 65% by weight, more preferably from 6 to 60% by weight and particularly preferably from 7 to 55% by weight, based in each case on the total weight of the liquid laundry detergent formulation.

[0203] Additional optional ingredients

[0204] Household cleaning formulations may contain one or more optional ingredients, for example they may contain conventional ingredients commonly used in detergent compositions, particularly laundry detergent compositions. Examples of optional ingredients include, but are not limited to, builders, bleaching agents, bleach-active compounds, bleach activators, bleach catalysts, photobleaches, dye transfer inhibitors, pigment protectants, anti-redeposition agents, dispersants, fabric softeners and antistatic agents, fluorescent brighteners, enzymes, enzyme stabilizers, foam regulators, defoamers, malodor reducers, preservatives, disinfectants, hydrotropes, fiber lubricants, anti-shrinkage agents, buffers, perfumes, processing aids, colorants, dyes, pigments, corrosion inhibitors, fillers, stabilizers and other conventional ingredients for washing or laundry detergent compositions.

[0205] polymer

[0206] For washing synergistic, polymers can be advantageously used in household cleaning formulations, particularly in liquid laundry detergent formulations. The polymer is preferably polyalkoxylated polyethyleneimine (EPEI). Polyethyleneimine is a material consisting of ethyleneimine units -CH2CH2NH-, and when branched, the hydrogen on the nitrogen is replaced by another chain of ethyleneimine units. These polyethyleneimines can be prepared, for example, by polymerizing ethyleneimine in the presence of catalysts such as carbonic acid gas, sodium bisulfite, sulfuric acid, hydrogen peroxide, hydrochloric acid, acetic acid, etc. The specific method for preparing these polyamine skeletons is disclosed in US2,182,306, US 3,033,746, US2,208,095, US2,806,839 and US2,553,696.

[0207] Household cleaning formulations, especially liquid laundry detergent formulations, may contain other polymeric materials, for example: dye transfer inhibiting polymers, anti-redeposition polymers and cotton soil release polymers, especially those based on modified cellulosic materials. In particular, when EPEI is not present, the formulation may additionally contain a polymer of polyethylene glycol and vinyl acetate, such as the lightly grafted copolymers described in WO2007 / 138054. Such amphiphilic graft polymers based on water-soluble polyalkylene oxides as grafting bases and side chains formed by polymerizing vinyl ester components have the ability to allow surfactant levels to be reduced while maintaining high levels of oily soil removal.

[0208] Hydrotropes

[0209] In at least one embodiment, the formulation comprises a hydrotrope. In this article, a "hydrotrope" is a solvent that is neither water nor a conventional surfactant, and that assists the dissolution of surfactants and other components, particularly any polymers and / or chelating agents in a liquid, to promote its isotropy. Hydrotropes are particularly useful in household cleaning formulations. Among suitable hydrotropes, the following are particularly noteworthy: monopropylene glycol (MPG), glycerol, sodium cumene sulfonate, ethanol, other glycols, such as dipropylene glycol, diethers and ureas. MPG and glycerol are preferred hydrotropes.

[0210] Enzymes

[0211] In at least one embodiment, the formulation, particularly the liquid laundry detergent formulation comprises an enzyme. In at least one embodiment, the enzyme is selected from protease, mannanase, pectate lyase, cutinase, esterase, lipase, amylase, cellulase, and combinations thereof. Not so preferred other enzymes can be selected from peroxidase and oxidase. The enzyme is preferably present with a corresponding enzyme stabilizer. By the gross weight of the formulation, the total enzyme content in the formulation is preferably 0 wt % to 5 wt %, more preferably 0.5 wt % to 5 wt %, even more preferably 1 wt % to 4 wt %.

[0212] Chelating agents

[0213] Chelating agents are preferably included in the formulation, especially in household cleaning formulations. Preferred chelating agents include organic phosphonates, alkane hydroxyphosphonates and carboxylates, which are available from Thermphos under the DEQUEST trademark. Preferred chelating agent levels are less than 10% by weight and preferably less than 5% by weight, based on the total weight of the formulation. A particularly preferred chelating agent is HEDP (1-hydroxyethylidene-1,1-diphosphonic acid), for example sold as Dequest 2010. Also suitable are 2066 (diethylenetriaminepenta(methylenephosphonic acid) or DTPMP heptasodium).

[0214] Buffer

[0215] In at least one embodiment, preparation, particularly liquid laundry detergent preparation comprises buffer.Except for the reagent for producing anionic surfactant by LAS or fatty acid optionally included, the presence of buffer is preferred for pH control.Possible buffer is one or more ethanolamines, such as monoethanolamine (MEA) or triethanolamine (TEA).They are preferably used in preparations with a level of 1.0 % by weight to 15 % by weight.Other suitable amino alcohol buffer materials can be selected from compounds with a molecular weight greater than 61g / mol, including MEA.Except for the materials already mentioned, suitable materials also include: monoisopropanolamine, diisopropanolamine, triisopropanolamine, monoaminohexanol, 2-[(2-methoxyethyl) methylamino]-ethanol, propanolamine, N-methylethanolamine, diethanolamine, monobutanolamine, isobutanolamine, monoamylamine, 1-amino-3-(2-methoxyethoxy)-2-propanol, 2-methyl-4-(methylamino)-2-butanol, or a mixture thereof. Potential alternatives to aminoethanol buffers are alkali metal hydroxides such as sodium hydroxide or potassium hydroxide.

[0216] The present invention also relates to the use of the combination according to the invention as an antimicrobial agent.

[0217] In at least one embodiment, the antimicrobial agent is an antibacterial agent or an antifungal agent. In at least one embodiment, the antimicrobial agent is an antibacterial agent. In at least one embodiment, the antimicrobial agent is an antifungal agent.

[0218] The present invention also relates to a method of reducing the effects of microorganisms in a formulation, wherein the method comprises adding a combination of the present invention to the formulation.

[0219] In at least one embodiment, the microorganism is a bacterium or a fungus. In at least one embodiment, the microorganism is a bacterium. In at least one embodiment, the microorganism is a fungus. The fungus can be, for example, a yeast or a mold.

[0220] In this document, including in all embodiments of all aspects of the invention, the following definitions apply unless specifically stated otherwise. All percentages are by weight (w / w) of the total composition. All ratios are by weight. "% by weight" means percentage by weight. References to "parts" are by weight, for example a mixture of 1 part X and 3 parts Y. "QS" or "QSP" means an amount sufficient for 100% or for 100 g. + / - indicates standard deviation. All ranges are inclusive and combinable. The number of significant figures represents neither a limitation on the indicated amounts nor an indication of the accuracy of the measurements. All measurements are understood to be made at 23°C and at ambient conditions, where "ambient conditions" means at a pressure of 1 atmosphere (atm) and at 50% relative humidity. "Relative humidity" refers to the ratio (expressed as a percentage) of the moisture content of the air compared to the saturated moisture level at the same temperature and pressure. A hygrometer can be used, in particular one from International's probe hygrometer measures relative humidity. In this article, "min" means "point" or "minute". In this article, "mol" means mole. In this article, "g" after the number means "gram". In this article, "include / comprising" means that there may be other steps and other ingredients in addition. "Include / comprising" covers the terms "consisting of..." and "consisting essentially of...". The compositions, formulations, methods, uses and processes of the present invention may include / contain the elements and limitations of the present invention described herein and any additional or optional ingredients, components / assemblies, steps or limitations described herein, consisting of them and consisting essentially of them. Unless otherwise specified, the embodiments and aspects described herein may include / contain elements, features or components / assemblies of other embodiments and / or aspects that are not clearly combined or illustrated, or may be combined with elements, features or components / assemblies of other embodiments and / or aspects that are not clearly combined. "In at least one embodiment" means one or more embodiments of the present invention, and optionally all embodiments or large subgroups of embodiments have the features described subsequently. When ranges of amounts are given, these are understood to be the total amount of the ingredient in the composition, or when more than one species falls within the range of an ingredient definition, the total amount of all ingredients in the composition matching the definition.

[0221] "Molecular weight" or "M.Wt." or "MW" and grammatical equivalents means number average molecular weight.

[0222] "Viscosity" at 25°C using a HAAKE rotational viscometer VT 550 with cooling / heating container and sensor system according to DIN 53019, 12.9 s -1 The shear rate was measured.

[0223] "Water soluble" refers to any material that dissolves sufficiently in water at 25°C to form a solution that is clear to the naked eye at a concentration of 0.1% by weight of the material in water. The term "water insoluble" refers to any material that is not "water soluble".

[0224] "Dry" or "substantially dry" means any compound or composition that contains less than 5%, less than 3%, or less than 2%, less than 1% or about 0% of liquid when measured at 25°C under ambient conditions. Such compounds or compositions in liquid form include water, oils, organic solvents, and other wetting agents. "Anhydrous" means that the composition contains less than 5%, less than 3%, or less than 2%, less than 1% or about 0% water by total weight of the composition.

[0225] "Substantially free" or "substantially free of" means less than 1%, or less than 0.8%, or less than 0.5%, or less than 0.3%, or about 0% of the total weight of the composition or formulation.

[0226] "Derivatives" include, but are not limited to, amide, ether, ester, amino, carboxyl, acetyl, acid, salt and / or alcohol derivatives of a given compound. In at least one embodiment, "derivatives thereof" means amide, ether, ester, amino, carboxyl, acetyl, acid, salt and alcohol derivatives.

[0227] The following examples are intended to illustrate the subject matter of the invention without limiting it. Example

[0228] Material

[0229] Flex is commercially available from Clariant. Chemical name: Capryl / hexanoyl anhydrous methyl glucamide (and) water, active ingredient content: 70% by weight. Capryl / hexanoyl anhydrous methyl glucamide is a mixture of a compound of formula (I) wherein R is -(CH2)8CH3 and a compound of formula (I) wherein R is -(CH2)6CH3.

[0230] SC is commercially available from Clariant. Chemical name: Sorbitan octanoate.

[0231] CGE is commercially available from Clariant. Chemical name: Caprylyl Glyceryl Ether.

[0232] Octylhydroxamic acid (hereinafter also referred to as CHA) is commercially available from TCI Chemicals.

[0233] Example 1

[0234] The antimicrobial properties of Velsan Flex, CHA and the combination of the two were studied against bacteria, fungi and molds: To test the inhibition of bacteria, Velsan Flex, CHA or the combination of the two were diluted in 1,2-propylene glycol and added to liquid Caso-Agar at 50°C in different concentrations and buffered to pH 7 (+ / - 0.2). To test the inhibition of fungi and molds, Velsan Flex, CHA or the combination of the two were diluted in 1,2-propylene glycol and added to liquid Sabouraud-4% Dextrose-Agar at 50°C in different concentrations and buffered to pH 5.6 (+ / - 0.2). Each solution was poured into a petri dish and inoculated with the same amount of bacteria, fungi or molds. The minimum inhibitory concentration (MIC) is the lowest concentration of each composition that inhibits the growth of each microorganism, while the next lowest dilution fails to inhibit the growth of the microorganism. The experiments were conducted under scientifically sound conditions so that appropriate comparisons can be made and conclusions can be drawn.

[0235] The results are shown in the following table:

[0236]

[0237]

[0238] It can be seen that the combination of the two ingredients shows a synergistic effect, since the MIC of the combination is lower than the MIC of the individual ingredients. This effect is observed on a broad spectrum of microorganisms, including both bacteria and fungi. This leads to the following advantages: preparations, such as cosmetic preparations or household preparations, can be preserved with less preservatives, reducing the possibility of adverse effects from antimicrobial active substances and saving resources.

[0239] Example 2

[0240] Corrosion protection demonstrated in challenge tests:

[0241] Synergistic effect and the ability of typical cosmetic preparations for wash-free application to preserve are also shown. The following examples show the challenge test results completed according to the 5.1.3 chapter of the 10th edition of the European Pharmacopoeia. The following test bacteria are used as representative microorganisms: Pseudomonas aeruginosa (Gram-negative organism, referred to as "Pa"), Staphylococcus aureus (Gram-positive organism, referred to as "Sa"), Escherichia coli (Escherichia coli) (Gram-negative organism, referred to as "Ec"), Candida albicans (Candida albicans) (fungus, referred to as "Ca") and Aspergillus terreus (Aspergillus terreus) (mold, referred to as "Ab").

[0242] The A criterion represents the recommended efficacy to be achieved. In justified cases where the A criterion cannot be achieved (e.g. due to increased risk of adverse reactions), the B criterion must be met. The A criterion relates to excellent protection of the formulation, and the B criterion is required to show adequate protection but requires the application of additional risk elimination measures related to packaging and raw material quality. For any tested organism, the F criterion means that the entire challenge test fails and the preservation and / or protection of the formulation is insufficient.

[0243] As a reference, unpreserved samples of each formulation were also tested.

[0244] Example 2A

[0245] As test systems, difficult-to-preserve preparations were used.

[0246] Leave-on type: O / W-cream gel

[0247]

[0248] The results of the challenge tests of the test formulations at pH 5 and pH 7 are shown in the table below.

[0249]

[0250] The unpreserved test system failed the challenge test for all test bacteria at pH 5 (entry 4). The use level of 1.35% Velsan Flex did not adequately preserve the formulation because it was not able to resist Ab (entry 2). Only a B-standard was obtained at the use level of 0.15% octylhydroxamic acid (entry 3). In contrast, the combination of the two ingredients at 1.35% and 0.15% use levels reached the A-standard for all test organisms, providing excellent protection for the formulation. The same formulation failed again at pH 7 (entry 8) for all test bacteria. When 0.15% CHA was used as a single preservative (entry 7), it only reached the B-standard for Sa and E.coli. 1.35% Velsan Flex also failed to preserve the formulation (entry 6). The combination of the two ingredients again showed an A-qualified excellent protection for all test organisms.

[0251] Example 2B

[0252] As test system the following preparation was used:

[0253]

[0254] The results of the challenge tests of the test formulations at pH 5 and pH 7 are shown in the table below.

[0255] Results at pH 5:

[0256]

[0257]

[0258] Results at pH 7:

[0259] entry 1 2 3 4 5 6 CHA 0.1％ 0.1％ 0.1％ Velsan SC 0.9％ 0.9％ Velsan CGE 0.9％ 0.9％ Unpreserved X Pseudomonas aeruginosa F A F B A A Staphylococcus aureus F F A A A A Escherichia coli F B B A A A Candida albicans F A B A A A Aspergillus terreus F A F F A A Overall Results F F F F A A

[0260] The combination of Velsan SC and CHA provided excellent results at pH 5 and pH 7. Likewise, the combination of Velsan CGE and CHA provided excellent results at pH 5 and pH 7. The combination provided significantly better results than the individual ingredients.

[0261] Example 3

[0262] Combinations of Examples of the Invention (amounts given in % by weight)

[0263]

[0264] Notes:

[0265] * = Compound according to formula (I) wherein R is -(CH2)8CH3; # = Compound according to formula (I) wherein R is -(CH2)6CH3. The combination is prepared by mixing its ingredients at room temperature.

[0266] Example 4

[0267] Combinations of Examples of the Invention (amounts given in % by weight)

[0268]

[0269] The combination is prepared by mixing its ingredients at room temperature.

[0270] Example 5

[0271] Combinations of Examples of the Invention (amounts given in % by weight)

[0272]

[0273] The combination is prepared by mixing its ingredients at room temperature.

[0274] Example 6

[0275] Example formulations of the invention (amounts given in % by weight)

[0276]

[0277]

[0278] Example 7

[0279] Example formulations of the invention (amounts given in % by weight)

[0280]

[0281]

[0282] Example 8

[0283] Example formulations of the invention (amounts given in % by weight)

[0284]

[0285]

[0286]

[0287] Example 9

[0288] Example formulations of the invention (amounts given in % by weight)

[0289]

[0290] Example 10

[0291] Example formulations of the invention (amounts given in % by weight)

[0292]

[0293] Embodiment 11

[0294] Example formulations of the invention (amounts given in % by weight)

[0295]

[0296]

Claims

1. A combination comprising (A) at least one compound selected from the group consisting of a compound of formula (I), sorbitan esters, isosorbide esters and glycerol ethers wherein R is selected from a saturated hydrocarbon chain having 5 to 23 carbon atoms, an unsaturated hydrocarbon chain having 5 to 23 carbon atoms, and mixtures thereof; and (B) at least one hydroxamic acid or a salt thereof.

2. The combination according to claim 1, wherein R in formula (I) is selected from a saturated hydrocarbon chain having 5 to 17 carbon atoms, an unsaturated hydrocarbon chain having 5 to 17 carbon atoms, and a mixture thereof, is preferably selected from saturated hydrocarbon chains having 5 to 13 carbon atoms, unsaturated hydrocarbon chains having 5 to 13 carbon atoms, and mixtures thereof, Particularly preferred are selected from saturated hydrocarbon chains having 7 to 9 carbon atoms, unsaturated hydrocarbon chains having 7 to 9 carbon atoms, and mixtures thereof.

3. The combination according to claim 1 or 2, wherein the sorbitan ester is a monoester, diester or triester of sorbitan with one or more C6-C20 fatty acids, preferably a monoester or diester of sorbitan with one or more C8-C14 fatty acids, particularly preferably a monoester or diester of sorbitan with caprylic acid.

4. The combination according to any one of claims 1 to 3, wherein the sorbitan ester is selected from sorbitan caprylate, sorbitan stearate, sorbitan olivate, sorbitan oleate, sorbitan caprate, sorbitan laurate, sorbitan myristate, sorbitan caproate, and mixtures thereof, preferably sorbitan caprylate.

5. The combination according to any one of claims 1 to 4, wherein the isosorbide ester is a monoester or diester of isosorbide with one or more C6-C20 fatty acids, preferably a monoester or diester of isosorbide with one or more C8-C14 fatty acids, particularly preferably a monoester or diester of isosorbide with caprylic acid.

6. The combination according to any one of claims 1 to 5, wherein the isosorbide ester is selected from isosorbide caprylate, isosorbide stearate, isosorbide olivate, isosorbide oleate, isosorbide caprate, isosorbide laurate, isosorbide myristate, isosorbide caproate, and mixtures thereof, preferably isosorbide caprylate.

7. The combination according to any one of claims 1 to 6, wherein the glycerol ether is a monoether or diether of glycerol and one or more C6-C20 fatty alcohols, preferably a monoether or diether of glycerol and one or more C8-C14 fatty alcohols, particularly preferably a monoether of glycerol and one or more C8 fatty alcohols.

8. A combination according to any one of claims 1 to 7, wherein the hydroxamic acid is selected from the hydroxamic acid of formula (II) Where R 1 Selected from saturated hydrocarbon chains having 5 to 23 carbon atoms, unsaturated hydrocarbon chains having 5 to 23 carbon atoms, and mixtures thereof.

9. A combination according to claim 8, wherein R in formula (II) 1 is selected from saturated hydrocarbon chains having 5 to 17 carbon atoms, unsaturated hydrocarbon chains having 5 to 17 carbon atoms, and mixtures thereof, is preferably selected from saturated hydrocarbon chains having 5 to 13 carbon atoms, unsaturated hydrocarbon chains having 5 to 13 carbon atoms, and mixtures thereof, Particularly preferred are selected from a saturated hydrocarbon chain having 7 carbon atoms, an unsaturated hydrocarbon chain having 7 carbon atoms, and a mixture thereof.

10. The combination according to any one of claims 1 to 9, wherein the weight ratio of (A) at least one compound selected from the group consisting of compounds of formula (I), sorbitan esters, isosorbide esters and glycerol ethers to (B) at least one hydroxamic acid or a salt thereof is 20:1 to 1:5, preferably 15:1 to 1:2, more preferably 12:1 to 1:1, and particularly preferably 10:1 to 3:

1.

11. The combination according to any one of claims 1 to 10, wherein the combination is a blend.

12. The combination according to claim 11, wherein the blend comprises 25 to 99 wt. %, preferably 40 to 80 wt. %, more preferably 55 to 70 wt. %, particularly preferably 60 to 65 wt. % of (A) at least one compound selected from the group consisting of compounds of formula (I), sorbitan esters, isosorbide esters and glycerol ethers, based on the total weight of the blend; and 1 to 50% by weight, preferably 2 to 20% by weight, more preferably 5 to 15% by weight, particularly preferably 8 to 12% by weight, based on the total weight of the blend, of (B) at least one hydroxamic acid or a salt thereof.

13. Use of a combination as defined in any one of claims 1 to 12 as an antimicrobial agent.

14. A method of reducing the impact of microorganisms in a formulation, wherein the method comprises adding a combination as defined in any one of claims 1 to 12 to the formulation.

15. A preparation comprising: (A) 0.1 to 10% by weight, preferably 0.2 to 3% by weight, particularly preferably 0.3 to 1.5% by weight, based on the total weight of the preparation, of at least one compound selected from the group consisting of compounds of formula (I), sorbitan esters, isosorbide esters and glycerol ethers wherein R is selected from a saturated hydrocarbon chain having 5 to 23 carbon atoms, an unsaturated hydrocarbon chain having 5 to 23 carbon atoms, and mixtures thereof; and (B) 0.01 to 1.5% by weight, preferably 0.05 to 0.5% by weight, particularly preferably 0.1 to 0.3% by weight, based on the total weight of the preparation, of at least one hydroxamic acid or a salt thereof.

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