Fishy smell-free DHA (docosahexaenoic acid) small dropping pill and

Abstract

The invention provides a fishy smell-free DHA (docosahexaenoic acid) small dropping pill and a preparation method thereof, the fishy smell-free DHA small dropping pill comprises: a capsule skin, the capsule skin is prepared from a gelatin solution comprising gelatin, glycerin and water, the capsule skin presents a frosted appearance, and the gelatin comprises mixed pigskin gelatin and fish skin gelatin; the DHA dropping pill comprises a capsule skin and a content wrapped in the capsule skin, the content comprises grease and N-acetylneuraminic acid, the grease at least comprises DHA algal oil, and the DHA dropping pill prepared by the scheme is not prone to oxidative deterioration under illumination, free of fishy smell and not prone to adhesion under high temperature or high humidity.

Description

Technical Field

[0001] The invention relates to the field of dripping pills, and in particular to a DHA small dripping pill without fishy smell and a preparation method thereof. Background Art

[0002] DHA has important physiological functions in the central nervous system, cardiovascular system and visual nervous system, and it is particularly important to supplement DHA during infancy and childhood. In the market, small drop-shaped gel candies are popular among consumers because of their fun to take, bursting sensation when bitten, thin capsule, easy chewing and dissolving, etc., and are widely used in the field of DHA nutritional supplementation.

[0003] DHA is an important ω-3 long-chain polyunsaturated fatty acid with a high degree of unsaturation, which poses some challenges to its stability. For example, under conditions of light, high temperature, and high humidity, DHA oils are prone to oxidation phenomena such as increased fishy smell, rancidity, increased peroxide value, and acid value, which reduces the stability and shelf life of the product.

[0004] Compared with transparent DHA small pills, small pills with frosted appearance have better light-shielding, antioxidant and anti-adhesion properties. However, the current frosting process for DHA small pills is achieved by adding modified starch or sugar alcohols to the capsule skin to change the surface properties of the rubber. This process requires precise control of the type, amount and method of adding the added substances. The operation process is relatively complicated and requires the introduction of other auxiliary materials besides nutrients and basic components of the rubber. It does not meet the requirements of clean labels, which in turn limits the application of frosting. Summary of the invention

[0005] The object of the present invention is to provide a DHA small drop pill without fishy smell and a preparation method thereof, wherein oil and N-acetylneuraminic acid are mixed to obtain the content and the proportion of gelatin in the capsule skin is adjusted to obtain DHA small drop pill without fishy smell with high process feasibility and stability.

[0006] To achieve the above objectives, the present technical solution provides a DHA small drop pill without fishy smell and a preparation method thereof, comprising:

[0007] A capsule skin, wherein the capsule skin is prepared from a gelatin solution comprising gelatin, glycerin and water, wherein the gelatin comprises mixed pig skin gelatin and fish skin gelatin, and wherein the capsule skin presents a frosted appearance;

[0008] The contents wrapped in the capsule skin include oil and N-acetylneuraminic acid, wherein the oil at least includes DHA algae oil.

[0009] This solution aims to solve the problems existing in the process and performance of existing DHA small drop pills, and to provide a kind of odorless DHA small drop pills and preparation method thereof which can achieve good nutritional supplementation effect, have stable frosting effect and meet the requirements of clean label. Through innovative formula design and process optimization, it overcomes the defect that the traditional frosting process needs to introduce more non-nutritional excipients, and improves the comprehensive quality and market competitiveness of the product. Specifically, unlike the traditional DHA small drop pills, this solution adds N-acetylneuraminic acid to the contents. The addition of N-acetylneuraminic acid can not only increase the formation of synapses, but also promote the release of neurotransmitters and other functions, so as to provide nutritional effects in combination with DHA; and N-acetylneuraminic acid can migrate to the capsule skin to form a frosted capsule skin, and cooperate with gelatin solution to form a stable frosted capsule skin to reduce the use of non-nutritional materials.

[0010] In some embodiments, the oil includes one or more of plant-derived oils, animal-derived oils, and microbial-derived oils other than DHA algae oil, wherein the plant-derived oil is selected from one or more combinations of walnut oil, flaxseed oil, and MCT oil, the animal-derived oil is selected from fish oil containing DHA and EPA, and the microbial-derived oil is selected from ARA oil fermented by microorganisms, wherein MCT oil refers to medium-chain triglycerides.

[0011] It should be noted that this program aims to provide an odorless DHA small drop pill that mainly provides DHA nutrients. Walnut oil in plant-derived oils is also rich in unsaturated fatty acids necessary for the human body, such as linolenic acid and linoleic acid. Flaxseed oil can be partially converted into DHA in the human body to cooperate with DHA algae oil to improve the body's absorption and utilization efficiency of DHA. MCT oil is particularly suitable for infants and other people whose digestive systems are not fully developed; EPA in animal-derived oils can work together with DHA to protect the human cardiovascular system and nervous system; microbial-derived oils combined with DHA can simulate the fatty acid composition of breast milk to provide comprehensive and balanced nutritional support for infants and young children.

[0012] In some embodiments, the contents of the fishy-free DHA small drop pills include a flavoring substance, wherein the flavoring substance is selected from one or more combinations of lemon oil and sweet orange oil. Lemon oil is selected as a flavoring substance to give the DHA small drop pills a distinct lemon flavor, which can effectively mask the fishy smell of DHA algae oil to improve the overall smell of the product. At the same time, lemon oil also has certain antioxidant properties to enhance the antioxidant capacity of the DHA small drop pills; selecting sweet orange oil as a flavoring substance can also give the DHA small drop pills a sweet citrus flavor to enhance the taste of the DHA small drop pills.

[0013] In order to allow N-acetylneuraminic acid to migrate into the capsule skin to form the "sand-returning" effect of the frosted capsule skin, this solution sets the ratio of N-acetylneuraminic acid to gelatin to 1:20 to 1:40. Specifically, N-acetylneuraminic acid coexists with ingredients such as oil in the contents. N-acetylneuraminic acid has a certain water solubility. When the capsule skin is formed, it is affected by the moisture and environmental conditions of the capsule skin, which prompts it to migrate from the contents to the capsule skin. The gelatin molecules have a certain spatial structure and charge distribution, and can interact with the N-acetylneuraminic acid molecules. When N-acetylneuraminic acid migrates to the capsule skin, it will combine with the gelatin molecules and gradually aggregate, eventually forming tiny crystal particles that precipitate on the surface of the capsule skin, presenting a frosted effect.

[0014] When the ratio of N-acetylneuraminic acid to gelatin is 1:40, this is the minimum threshold for achieving the "returning sand" effect. At this ratio, there are a sufficient number of N-acetylneuraminic acid molecules that can interact with gelatin molecules and migrate to the capsule skin. As the ratio of N-acetylneuraminic acid increases, more molecules can participate in the "returning sand" process, and the frosting effect will gradually become more obvious; however, if the ratio of N-acetylneuraminic acid is too high, it will also cause some problems: on the one hand, too much N-acetylneuraminic acid will change the physical and chemical properties of the capsule skin, such as destroying the gel strength and viscosity of gelatin, thereby affecting the formation of droplets during the dripping process and the wrapping effect of the capsule skin; on the other hand, excessive precipitation of N-acetylneuraminic acid on the capsule skin may cause excessive frosting, affecting the integrity and mechanical properties of the capsule skin, making the capsule skin fragile and easy to break during processing, storage or transportation.

[0015] In addition, in order to further improve the problem of unstable rubber process caused by N-acetylneuraminic acid, the mass ratio of fish skin gelatin and pig skin gelatin contained in gelatin is set to 0.1-1:1 in this scheme. Preferably, the mass ratio of fish skin gelatin and pig skin gelatin in gelatin is 0.5:1.

[0016] Specifically, pigskin gelatin has relatively low viscosity and good formability, and its molecular chain structure is relatively regular, which can provide a stable basic framework for the capsule skin and help form a uniform capsule skin shape during the dripping process; fish skin gelatin has a higher viscosity and contains more hydrophobic groups in its molecular chain, which enables it to enhance the interaction between molecules when mixed with pigskin gelatin and form a tighter network structure. This network structure can better lock in moisture, reduce the interaction when in contact with N-acetylneuraminic acid, and enable the capsule skin to withstand a certain external force without being easily broken, thereby protecting the stability of the colloid.

[0017] In addition, the scheme sets the mass ratio of fish skin gelatin to pig skin gelatin in the range of 0.1 to 1:1, so that the high viscosity of fish skin gelatin can make up for the loose structure problem that pig skin gelatin may have when interacting with N-acetylneuraminic acid. For example, when N-acetylneuraminic acid is present, its acidity may affect the hydrogen bonding and other interactions between gelatin molecules, causing the capsule skin to become soft, deformed or difficult to form, while an appropriate amount of fish skin gelatin can enhance the interaction between molecules and maintain the mechanical strength and stability of the capsule skin.

[0018] In some embodiments, the gelatin solution contains sweeteners, wherein the sweeteners are selected from one or more of sorbitol, xylitol, erythritol, mogroside, and stevioside. The addition of sweeteners can further improve the taste of the odorless DHA pellets.

[0019] In some embodiments, the odorless DHA pellets include:

[0020] The capsule skin is prepared from a gelatin solution containing 60 to 180 parts by weight of gelatin, 20 to 60 parts by weight of glycerin, and 90 to 110 parts by weight of water, wherein the gelatin contains 60 to 120 parts by weight of pig skin gelatin and 1 to 60 parts by weight of fish skin gelatin;

[0021] The contents wrapped in the capsule skin include oil and N-acetylneuraminic acid in a weight ratio of 2 to 10, wherein the oil at least includes DHA algae oil in a weight ratio of 70 to 98.

[0022] In a specific embodiment, the odorless DHA pellets include:

[0023] The capsule skin is prepared from a gelatin solution containing 120 parts by weight of gelatin, 24 parts by weight of glycerin and 100 parts by weight of water, wherein the gelatin contains 80 parts by weight of pig skin gelatin and 40 parts by weight of fish skin gelatin;

[0024] The contents wrapped in the capsule skin include oil and N-acetylneuraminic acid in a weight ratio of 5, wherein the oil includes at least 85 weight parts of DHA algae oil.

[0025] It should be noted that "parts by mass" refers to the basic unit of measurement for expressing the mass ratio of multiple components, and 1 part can represent any unit mass. In this scheme, "a gelatin solution is prepared with a mass ratio of 120 gelatin, 24 glycerin and 100 water" means that the mass ratio of gelatin: glycerin: water is 120:24:100. Unlike the mass ratio, the mass ratio of all components is not limited to 100 parts.

[0026] In a second aspect, the technical solution provides a method for preparing odorless DHA small drop pellets, comprising the following steps:

[0027] Pour the oil and N-acetylneuraminic acid into an emulsifying tank and stir to evenly mix to obtain the contents, wherein the oil at least includes DHA algae oil;

[0028] Pour water into a gelling tank and set a high temperature environment, add glycerin and gelatin into the gelling tank in sequence, and stir the gelling until the gelatin is completely dissolved to obtain a transparent colloidal solution, wherein the gelatin includes pig skin gelatin and fish skin gelatin;

[0029] Pour the gelatin solution and the contents into a coaxial double-nozzle dropping pill making device and extrude them to obtain dropping pills, wherein the gelatin solution is ejected from an external nozzle of the coaxial double-nozzle dropping pill making device, and the contents are ejected from an internal nozzle of the coaxial double-nozzle dropping pill making device, and the temperature of the contents is lower than the temperature of the gelatin solution;

[0030] After the pellets are shaped and dried, small DHA pellets with frosted appearance and no fishy smell are obtained.

[0031] As mentioned above, in some embodiments, the oil includes one or more of plant-derived oils, animal-derived oils, and microbial-derived oils other than DHA algae oil, wherein the plant-derived oil is selected from one or more combinations of walnut oil, flaxseed oil, and MCT oil, the animal-derived oil is selected from fish oil containing DHA and EPA, and the microbial-derived oil is selected from ARA oil fermented by microorganisms.

[0032] In some embodiments, the contents of the odorless DHA pellets include flavoring substances, wherein the flavoring substances are selected from one or more combinations of lemon oil and sweet orange oil. At this time, the oil, flavoring substances and N-acetylneuraminic acid are poured into an emulsifying tank and stirred and mixed evenly to obtain the contents.

[0033] In some embodiments, the ratio of N-acetylneuraminic acid to gelatin is set to 1:20 to 1:40.

[0034] In some embodiments, the mass ratio of fish skin gelatin to pig skin gelatin contained in gelatin is 0.1:1 to 1:1.

[0035] In some embodiments, the gelatin solution contains a sweet substance, wherein the sweet substance is selected from one or more of sorbitol, xylitol, erythritol, mogroside, and steviol glycoside. At this time, water is poured into the gelatinization tank and a high temperature environment is set. Glycerin, the sweet substance, and gelatin are added to the gelatinization tank in turn, and the gelatinization is stirred until the gelatin is completely dissolved to obtain a transparent colloidal solution.

[0036] Regarding the preparation process, in some embodiments, this solution pours oil and N-acetylneuraminic acid into an emulsifying tank, sets the stirring speed to 30-40 Hz, stirs for 20-30 min, starts vacuuming synchronously, sets the vacuum degree to -0.5--0.1 MPa, and stirs and mixes to obtain the contents uniformly. This solution can also achieve uniform distribution of oil and N-acetylneuraminic acid within a long time (such as 30 min) by setting a lower stirring speed (such as 30 Hz), and in addition, the vacuuming operation can make the contents more closely mixed under a negative pressure environment, and can also prevent oil oxidation.

[0037] Preferably, the oil and N-acetylneuraminic acid are poured into an emulsifying tank, the stirring speed is set to 35 Hz, the mixture is stirred for 20 min, vacuuming is started simultaneously, the vacuum degree is set to -0.1 MPa, and the mixture is stirred and mixed to obtain the contents.

[0038] In some embodiments, water is poured into a gelling tank and the high temperature is set to 80°C to 85°C. Glycerin and gelatin are added to the gelling tank in sequence and stirred. The stirring speed is set to 40 to 50 Hz. The gelling is stirred until the gelatin is completely dissolved to obtain a colloidal solution. After vacuum degassing, the solution is placed at 80°C to 85°C for insulation. It should be noted that when the colloidal solution is clear and transparent, the gelatin is deemed to be completely dissolved. This solution dissolves gelatin at a temperature of 80°C to 85°C, so that the colloidal solution formed by gelatin, water and glycerin has good fluidity and stability, so that it can pass through the nozzle smoothly during dripping to form a uniform capsule skin.

[0039] Preferably, water is poured into a gelling tank and the high temperature is set to 80°C. Glycerin and gelatin are added to the gelling tank in sequence and stirred. The stirring speed is set to 45 Hz. The gelling is stirred until the gelatin is completely dissolved to obtain a transparent colloidal solution. After vacuum degassing, the solution is kept warm at 80°C for later use.

[0040] In some embodiments, the freezing force of pig skin gelatin is 250 and the viscosity is 4.2 mPa.s; the freezing force of fish skin gelatin is 200 and the viscosity is 8.48 mPa.s.

[0041] In some embodiments, the coaxial double-nozzle drop-pill making equipment of the present scheme comprises a coaxially arranged internal nozzle and an external nozzle, wherein the gelatin solution is ejected from the external nozzle of the coaxial double-nozzle drop-pill making equipment, and the contents are ejected from the internal nozzle of the coaxial double-nozzle drop-pill making equipment, and the contents and the gelatin solution are extruded simultaneously to form a double-layer structured drop-pill.

[0042] In some embodiments, the temperature of the contents is set at 40°C and the temperature of the gelatin solution is set at 85°C.

[0043] Regarding the shaping and drying of the dropping pills, in some specific embodiments, the dropping pills are immersed in caprylic and capric glycerides and refrigerated at 4°C for 3 hours to shape, the deoiled dropping pills are slowly placed in a rotating cage, a piece of oil-absorbing cotton is added, the feeding port and the wind shield are closed, the drying conditions are temperature ≤25°C, humidity ≤65, and drying for 6 hours to make the moisture content of the rubber less than 15%.

[0044] In addition, in some embodiments, after obtaining the odorless DHA pellets, they are screened with a screen of a specific size and packaged internally. The specific screen size is adjusted according to the actual process requirements. In the embodiment of this scheme, the screen size is 6.0±0.5mm; the specific internal packaging process is also adjusted according to the actual process requirements, using an eight-row filling and packaging machine for nitrogen packaging, requiring the oxygen content in the strip bag to be less than 2%.

[0045] Compared with the prior art, this technical solution has the following characteristics and beneficial effects:

[0046] The odorless DHA small drop pills provided by this solution combine oil and N-acetylneuraminic acid, which work together with N-acetylneuraminic acid to promote brain development, fully meet the needs of different groups of people, and play a synergistic role in multiple nutrients. Through the precise ratio of N-acetylneuraminic acid and gelatin, the "return to sand" is achieved to form a frosted capsule skin, which is stable and does not require additional non-nutritional excipients, and meets the clean label. At the same time, pig skin gelatin and fish skin gelatin are mixed in a specific mass ratio to improve the stability of the rubber process, enhance the performance of the capsule skin, and greatly increase the content of DHA in the content and the flavor stability. At the same time, the odorless DHA small drop pills prepared by this solution are not easy to oxidize and deteriorate under light, have no fishy smell, and are not easy to stick under high temperature or high humidity. BRIEF DESCRIPTION OF THE DRAWINGS

[0047] Figure 1 These are appearance observation diagrams of commercially available sample A and comparative examples 1 to 4.

[0048] Figure 2 It is a schematic diagram of the non-adhesive state of Example 1 and the adhesive state and the separation state after adhesion of Comparative Example 8. DETAILED DESCRIPTION

[0049] The following will be combined with the accompanying drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field belong to the scope of protection of the present invention.

[0050] Experimental group design:

[0051] Example 1 Odorless DHA small drop pills and preparation method thereof:

[0052] (1) Preparation of contents: According to the formula, weigh 85 parts of DHA algae oil and 5 parts of N-acetylneuraminic acid and pour them into the emulsification tank. Stir at a speed of 35 Hz for more than 20 minutes, and start vacuuming at the same time, setting the vacuum degree to -0.1 MPa, mix well and set aside.

[0053] (2) Preparation of gelatin solution: Weigh 100 parts of water and pour it into a gelatinizing tank, and set the temperature of the gelatinizing tank to 80°C; then pour 24 parts of glycerin into the gelatinizing tank, and finally pour 80 parts of pig skin gelatin (freezing power 250, viscosity: 4.2 mPa.s) and 40 parts of fish skin gelatin (freezing power 200, viscosity: 8.48 mPa.s), set the stirring tank speed to 45 Hz, stir the gelatinizing tank until the gelatin is completely dissolved and the gelatin solution is clear and transparent, vacuum degassing, and keeping warm at 80°C for use.

[0054] (3) Dropping: An inner nozzle and an outer nozzle with increasing diameters at the same center (both are coaxial nozzles) are used. The solution of the small droplet contents is extruded from the inner nozzle, and the solution of the small droplet capsule is extruded from the outer nozzle at the same time to form a double-layer structure composite. The temperature of the rubber liquid is controlled at 85°C and the temperature of the core liquid is controlled at 40°C.

[0055] (4) Shaping: Immerse the prepared balls in caprylic and capric glycerides and refrigerate at 4°C for 3 h to set;

[0056] (5) Drying: slowly put the de-oiled pellets into a rotating cage, add a piece of oil-absorbing cotton, close the feeding port and the wind shield, and dry under the conditions of temperature ≤ 25°C, humidity ≤ 65, and dry for 6 hours until the moisture content of the rubber is less than 15%;

[0057] (6) Screening: Use a sieve specified for the particle size of the pellets (6.0±0.5 mm) to screen each plate of pellets to obtain odorless DHA pellets with a frosted appearance.

[0058] (7) Inner packaging: An eight-row filling and packaging machine is used for nitrogen packaging, and the oxygen content in the strip bag is required to be less than 2%.

[0059] The ingredients of the odorless DHA pellets prepared in Example 1 are shown in Table 1 below:

[0060] Table 1 Ingredients of DHA small drop pills without fishy smell

[0061]

[0062] Embodiment 2:

[0063] The process is the same as that of Example 1, the main difference being that 5 parts of sweet orange oil and 5 parts of erythritol are added to the contents and the capsule skin, respectively.

[0064] Comparative Example 1

[0065] The process is the same as that of Example 1. The main difference is that 3 parts of N-acetylneuraminic acid are added when the content is prepared, and 120 parts of pig skin gelatin (freezing strength 250, viscosity: 4.2 mPa.s) are added when the capsule skin is prepared.

[0066] Comparative Example 2

[0067] The process is the same as that of Example 1. The main difference is that 4 parts of N-acetylneuraminic acid are added when the content is prepared, and 120 parts of pig skin gelatin (freezing strength 250, viscosity: 4.2 mPa.s) are added when the capsule skin is prepared.

[0068] Comparative Example 3

[0069] The process is the same as that of Example 1. The main difference is that 5 parts of N-acetylneuraminic acid are added when the content is prepared, and 120 parts of pig skin gelatin (freezing strength 250, viscosity: 4.2 mPa.s) are added when the capsule skin is prepared.

[0070] Comparative Example 4

[0071] The process is the same as that of Example 1. The main difference is that 6 parts of N-acetylneuraminic acid are added when the content is prepared, and 120 parts of pig skin gelatin (freezing strength 250, viscosity: 4.2 mPa.s) are added when the capsule skin is prepared.

[0072] Comparative Example 5

[0073] The process is the same as that of Example 1. The main difference is that 103 parts of pig skin gelatin (freezing force 250, viscosity: 4.2 mPa.s) and 17 parts of fish skin gelatin (freezing force 200, viscosity: 8.48 mPa.s) are added during the preparation of the capsule skin.

[0074] Comparative Example 6

[0075] The process is the same as that of Example 1. The main difference is that 96 parts of pig skin gelatin (freezing force 250, viscosity: 4.2 mPa.s) and 24 parts of fish skin gelatin (freezing force 200, viscosity: 8.48 mPa.s) are added during the preparation of the capsule skin.

[0076] Comparative Example 7

[0077] The process is the same as that of Example 1. The main difference is that 60 parts of pig skin gelatin (freezing force 250, viscosity: 4.2 mPa.s) and 60 parts of fish skin gelatin (freezing force 200, viscosity: 8.48 mPa.s) are added during the preparation of the capsule skin.

[0078] Performance Testing:

[0079] Appearance observation: Place on a white background and observe under natural light.

[0080] Drop test of pills: 8 DHA small pills were randomly selected from each group of examples or comparative examples, and the DHA small pills were made to freely fall from a height of 10 cm on a smooth test bench. Those without cracks passed the test.

[0081] Sensory evaluation: 30 selected sensory evaluators were selected to evaluate their preferences with reference to the preference rating table in Table 2, and to describe the reasons:

[0082] Table 2 Preference rating table

[0083] Points Preferences 0 Very dislike 1 dislike 2 A little bit dislike 3 It doesn't matter 4 I like it a little bit 5 like 6 Like it very much .

[0084] Strong light irradiation: Use the standardized equipment "adjustable light box" and set the light intensity to 4500lx±500lx. All samples are placed in the open and irradiated with strong light.

[0085] The DHA small drop pellets of Comparative Examples 1 to 4 were subjected to appearance observation, drop test and sensory evaluation to obtain test data as shown in Table 3 below:

[0086] Table 3 Drop test and sensory evaluation test data

[0087]

[0088] The product pictures of commercially available sample A (transparent small drop pills, domestically produced) and the DHA small drop pills obtained in Comparative Examples 1, 2, 3 and 4 and their preparation methods are shown in FIG. Figure 1 shown.

[0089] According to the results of Comparative Examples 1-4, with the increase of the amount of N-acetylneuraminic acid, the frosting becomes more and more obvious. When the amount is added to 6%, the taste is unacceptable due to the acidity of the material, and there is local excessive frosting, which affects the appearance. 4% N-acetylneuraminic acid can meet the requirements of frosting effect and taste, but the yield is low. It may be because its low pH value destroys the interaction force between gel molecules, thereby causing the structure of the gel to disintegrate. The rubber needs to be further optimized.

[0090] The DHA small drop pellets of Example 1, Example 2, Comparative Examples 5 to 7 were subjected to appearance observation, drop test and sensory evaluation to obtain test data as shown in Table 4 below:

[0091] Table 4 Drop test and photosensitivity evaluation test data

[0092] .

[0094] According to Example 1 and Comparative Examples 5-7, it can be concluded that the yield of small drop pills can be improved with the increase of the amount of fish skin gelatin added. It may be that the viscosity of fish skin gelatin is much higher than that of pig skin gelatin, and it is easier to form a network structure: after the gelatin particles are dissolved in water, they can attract and interweave each other to form a network structure of stacked layers. This easier water-locking property can completely fill the water in the gel gap, reduce the combination with water-soluble acidic raw materials, and thus protect the colloid. However, when the amount of fish skin gelatin is increased to 1:1, the gelatin power is insufficient, the tensile strength and elasticity are deteriorated, the hardness of the pills is not enough, and the drop resistance test does not meet the standard. The fish skin gelatin and pig skin gelatin have the highest yield at 0.5:1.

[0095] From the comparison results of Example 2 and Example 1, it can be seen that the addition of the flavoring substance sweet orange oil and the seasoning substance erythritol to the formula improves the flavor of the product and significantly increases the preference.

[0096] The results of the changes in the indicators of the DHA small drop pills obtained after the samples of Example 1, Comparative Examples 1 to 4 and Comparative Example 8 were irradiated with strong light are shown in Table 5 below:

[0097] Table 5 Results of changes in indicators of DHA small drop pills irradiated with strong light

[0098]

[0099]

[0100] Note: Comparative Example 8 is a domestically produced frosted small drop pill purchased.

[0101] It should be noted that the lower the peroxide value and anisidine value, the lower the degree of oxidation of the algae oil. The standards are: anisidine value ≤15, peroxide value ≤0.25g / 100g, acid value (KOH) ≤3mg / g.

[0102] According to the flavor and physical and chemical index results of Example 1 and Comparative Examples 1 to 4 and Comparative Example 8, it can be concluded that the scrub of the capsule skin can reduce the oxidation of the fat in the content to a certain extent, indicating that the scrub can effectively prevent light from penetrating and also play an antioxidant role. The DHA small drop pills of Example 1 showed good antioxidant properties, and were slightly better than Comparative Examples 3, Comparative Example 4 and commercially available samples, which may be related to the better air tightness of the fish skin gelatin.

[0103] In addition, the adhesion degree of Example 1, Comparative Examples 1 to 4 and Comparative Example 8 was tested at different temperatures and humidities. The rubber adhesion results of DHA small droplets at different temperatures are shown in Table 6 below, and the rubber adhesion results of DHA small droplets at different humidities are shown in Table 7 below:

[0104] Table 6 DHA small pills rubber adhesion results at different temperatures

[0105]

[0106] .

[0108] According to the adhesion conditions of Example 1 and Comparative Examples 1 to 4 and Comparative Example 8, it can be concluded that scrubbing the capsule skin can improve the temperature resistance of the DHA small droplets. The DHA small droplets scrubbed with N-acetylneuraminic acid show good temperature resistance and are slightly better than commercially available samples.

[0109] Table 7 DHA small pills rubber adhesion results at different humidity

[0110]

[0111] According to the adhesion results of Example 1 and Comparative Examples 1 to 4 and Comparative Example 8, it can be concluded that scrubbing the capsule skin can improve the moisture resistance of the DHA small drop pellets. The DHA small drop pellets scrubbed with N-acetylneuraminic acid show good moisture resistance and are slightly better than the commercially available samples. The scheme of Comparative Example 8 is adhered at 75% RH, and the appearance is concave after separation. Figure 2 shown.

[0112] It is to be understood that the term "one" should be understood as "at least one" or "one or more", that is, in one embodiment, the number of an element may be one, while in another embodiment, the number of the element may be multiple, and the term "one" should not be understood as a limitation on the quantity.

[0113] The present invention is not limited to the above-mentioned optimal implementation mode. Anyone can derive other various forms of products under the inspiration of the present invention. However, no matter what changes are made in the shape or structure, all technical solutions that are the same or similar to those of the present application fall within the protection scope of the present invention.

Claims

1. A DHA small drop pill without fishy smell and a preparation method thereof, characterized in that: include: A capsule skin, wherein the capsule skin is prepared from a gelatin solution comprising gelatin, glycerin and water, wherein the gelatin comprises mixed pig skin gelatin and fish skin gelatin, and wherein the capsule skin presents a frosted appearance; The contents wrapped in the capsule skin include oil and N-acetylneuraminic acid, wherein the oil at least includes DHA algae oil.

2. The odorless DHA small drop pill according to claim 1, characterized in that: The ratio of N-acetylneuraminic acid to gelatin is set at 1:20 to 1:

40.

3. The odorless DHA small drop pill according to claim 1, characterized in that: The mass ratio of fish skin gelatin to pig skin gelatin in the gelatin is set to 0.1:1 to 1:

1.

4. The odorless DHA small drop pill according to claim 1, characterized in that: The capsule skin is prepared from a gelatin solution containing 60 to 180 parts by weight of gelatin, 20 to 60 parts by weight of glycerol and 90 to 110 parts by weight of water, wherein the gelatin contains 60 to 120 parts by weight of pig skin gelatin and 1 to 60 parts by weight of fish skin gelatin; the content includes oil and fat and 2 to 10 parts by weight of N-acetylneuraminic acid, wherein the oil and fat at least includes 70 to 98 parts by weight of DHA algae oil.

5. The odorless DHA small drop pill according to claim 1, characterized in that: The gelatin solution contains sweeteners, wherein the sweeteners are selected from one or more of sorbitol, xylitol, erythritol, mogroside, and stevioside; the contents include flavoring substances, wherein the flavoring substances are selected from one or more combinations of lemon oil and sweet orange oil.

6. A method for preparing odorless DHA small drop pills, characterized in that: The following steps are involved: Pour the oil and N-acetylneuraminic acid into an emulsifying tank and stir to evenly mix to obtain the contents, wherein the oil at least includes DHA algae oil; Pour water into a gelling tank and set a high temperature environment, add glycerin and gelatin into the gelling tank in sequence, and stir the gelling until the gelatin is completely dissolved to obtain a transparent colloidal solution, wherein the gelatin includes pig skin gelatin and fish skin gelatin; The gelatin solution and the contents are sucked into a coaxial double-nozzle drop-pill making device and extruded to obtain drop-pills, wherein the gelatin solution is ejected from an external nozzle of the coaxial double-nozzle drop-pill making device, and the contents are ejected from an internal nozzle of the coaxial double-nozzle drop-pill making device, and the temperature of the contents is lower than the temperature of the gelatin solution; After the pellets are shaped and dried, odorless DHA small pellets with a frosted appearance are obtained.

7. The method for preparing a DHA small drop pill without fishy smell according to claim 6, characterized in that: The mass ratio of fish skin gelatin and pig skin gelatin in the gelatin is set to 0.1:1 to 1:1, and the ratio of N-acetylneuraminic acid to gelatin is set to 1:20 to 1:

40.

8. The method for preparing a DHA small drop pill without fishy smell according to claim 6, characterized in that: The coaxial double-nozzle drop-pill making equipment comprises a coaxially arranged internal nozzle and an external nozzle, wherein the gelatin solution is ejected from the external nozzle of the coaxial double-nozzle drop-pill making equipment, the contents are ejected from the internal nozzle of the coaxial double-nozzle drop-pill making equipment, and the contents and the gelatin solution are extruded simultaneously to form drop-pills with a double-layer structure, the temperature of the contents is set to 40°C, and the temperature of the gelatin solution is set to 85°C.

9. The method for preparing a DHA small drop pill without fishy smell according to claim 6, characterized in that: Pour the oil and N-acetylneuraminic acid into an emulsifying tank, set the stirring speed to 30-40 Hz, stir for 20-30 minutes, start vacuuming simultaneously, set the vacuum degree to -0.5-0.1 MPa, and stir to mix evenly to obtain the contents.

10. The method for preparing a DHA small drop pill without fishy smell according to claim 6, characterized in that: Pour water into the gelling tank and set the high temperature to 80℃~85℃. Add glycerin and gelatin to the tank in turn and stir. Set the stirring speed to 40~50HZ. Stir the gelling until the gelatin is completely dissolved to obtain a transparent colloidal solution. After vacuum degassing, keep warm at 80℃~85℃ for later use.

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