Pharmaceutical composition for treating alopecia and preparation method thereof

Abstract

The invention discloses a pharmaceutical composition for treating alopecia and a preparation method thereof. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 7 to 13g of radix bupleuri, 11 to 19g of radix angelicae sinensis, 13 to 18g of radix rehmanniae recen, 7 to 13g of semen persicae, 7 to 14g of flos carthami, 8 to 13g of rhizoma chuanxiong, 9 to 11g of fructus aurantii, 7 to 13g of radix platycodonis, 11 to 18g of radix achyranthis bidentatae, 3 to 8g of liquorice root, 6 to 13g of radix paeoniae rubra and 5 to 8g of radix saposhnikoviae. The preparation method of the pharmaceutical composition comprises the following steps: 1) respectively taking radix bupleuri, angelica sinensis, radix rehmanniae recen, safflower, ligusticum wallichii, fructus aurantii, platycodon grandiflorum, radix achyranthis bidentatae, liquorice, radix paeoniae rubra and divaricate saposhnikovia root in parts by weight for later use; (2) taking the peach kernels in parts by weight, and grinding the peach kernels for later use; (3) sequentially putting the raw materials taken in the step (1) and the crushed peach kernels into a container, then adding purified water, heating and boiling, and filtering out liquid medicine to obtain initial liquid medicine; and 4) adding the obtained initial liquid medicine into purified water, heating with strong fire again, boiling for 1 minute, decocting with slow fire for 2.5-3.5 hours, and cooling to obtain the target product.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a pharmaceutical composition for treating hair loss and a preparation method thereof. Background Art

[0002] Hair loss refers to the phenomenon of hair loss. Generally, hair loss can be divided into two basic types, namely permanent hair loss and temporary hair loss. Permanent hair loss is the common male baldness. In some European countries, the male baldness rate is as high as 40%. At the beginning of permanent hair loss, the edge of the forehead is obviously retracted, and the hair on the top of the head is sparse. Then it gradually develops and finally develops to only a circle of sparse hair on the back and sides of the head. The main reasons are: 1) genetic factors, lack or imbalance of male hormones in the blood circulation; 2) excessive obesity; 3) scars left by various skin diseases or skin injuries, congenital hair stunting, and severe damage to hair follicles caused by chemicals or physical causes can all cause permanent hair loss. Temporary hair loss is often caused by diseases with high fever. In addition, X-rays, ingestion of heavy metals, malnutrition, certain inflammatory skin diseases, chronic wasting diseases, and endocrine disorders can also cause temporary hair loss.

[0003] Hair loss has a great impact on people's lives. First of all, hair loss seriously affects the appearance and appearance, and it is easy to look old. It also affects job hunting, narrows interpersonal relationships, and increases mental stress. Therefore, the treatment of hair loss is urgent. There are currently two treatment options for male pattern baldness: the first method is hair transplantation, which is to transplant the hair follicles of the scalp where the hair still grows to the place where the hair does not grow, that is, from the back of the head to the front; the second method is local application of medicine, which can effectively prevent continued hair loss caused by various reasons and promote hair regeneration in bald or sparse hair areas; however, these existing treatment methods are only indicators and not cure the root cause. Summary of the invention

[0004] The technical problem to be solved by the present invention is to overcome the defects of the above-mentioned technology and provide a pharmaceutical composition for treating hair loss and a preparation method thereof.

[0005] To solve the above technical problems, the technical solution provided by the present invention is a pharmaceutical composition for treating hair loss, which comprises the following raw materials in parts by weight: 7-13g of bupleurum, 11-19g of angelica, 13-18g of raw rehmannia, 7-13g of peach kernel, 7-14g of safflower, 8-13g of chuanxiong, 9-11g of fructus aurantii, 7-13g of platycodon, 11-18g of achyranthes bidentata, 3-8g of licorice, 6-13g of red peony root, and 5-8g of siler.

[0006] Furthermore, the pharmaceutical composition comprises the following raw materials in parts by weight: 10g of bupleurum, 15g of angelica, 15g of raw rehmannia, 10g of peach kernel, 10g of safflower, 10g of chuanxiong, 10g of fructus aurantii, 10g of platycodon, 15g of achyranthes bidentata, 6g of liquorice, 10g of red peony root, and 6g of siler.

[0007] Furthermore, the pharmaceutical composition comprises the following raw materials in parts by weight: 9g of bupleurum, 11g of angelica, 15g of raw rehmannia, 11g of peach kernel, 11g of safflower, 9g of chuanxiong, 9g of fructus aurantii, 13g of platycodon, 15g of achyranthes bidentata, 5g of liquorice, 9g of red peony root, and 7g of siler.

[0008] Furthermore, a second object of the present invention is to provide a method for preparing the above-mentioned pharmaceutical composition, comprising the following steps:

[0009] Step 1) respectively taking Bupleurum, Chinese Angelica, Radix Rehmanniae, Carthamus tinctorius, Rhizoma Chuanxiong, Fructus Aurantii Immaturus, Platycodon grandiflorum, Achyranthes bidentata, Licorice, Radix Paeoniae Rubra, Saposhnikovia divaricata by weight and setting aside;

[0010] Step 2) taking peach kernels by weight and crushing the peach kernels for later use;

[0011] Step 3) Put the raw materials obtained in step 1 and the crushed peach kernel into a container in sequence, then add purified water, first heat with high heat, and after boiling, continue to simmer for 40 minutes with low heat, filter out the medicinal solution after cooling, and obtain the initial medicinal solution;

[0012] Step 4) Add the obtained initial drug solution into purified water, heat it again with high heat, boil it for 1 minute, then simmer it with low heat for 2.5-3.5 hours, and obtain the target product after cooling.

[0013] Furthermore, the amount of pure water added in step 3 needs to cover the raw material by 3-5 cm.

[0014] Furthermore, in step 4, the amount of pure water added is 1.8-2.1 liters.

[0015] Compared with the prior art, the invention has the following advantages: the pharmaceutical composition provided by the invention has a reasonable formula design, and uses bupleurum, angelica, raw rehmannia, peach kernel, safflower, ligusticum chuanxiong, fructus aurantii, platycodon grandiflorum, achyranthes bidentata, liquorice, red peony root and saposhnikovia root as raw materials; wherein angelica, raw rehmannia, ligusticum chuanxiong, red peony root, peach kernel and safflower have the effects of promoting the dredging and dilation of capillaries, replenishing blood and activating blood circulation, and activating blood circulation and promoting hair growth; bupleurum has the effects of reconciling the exterior and the interior, soothing the liver and relieving depression, raising yang and lifting depression, and relieving fever and stopping malaria; through the complementary and joint action of the above drugs, the pharmaceutical composition has the effects of removing dampness, replenishing qi and blood, preventing hair loss and promoting hair growth from the inside out, and is suitable for patients suffering from hair loss and alopecia areata for a long time, and has remarkable effects of preventing hair loss and promoting hair growth; meanwhile, the invention is a pure Chinese medicine external preparation, and has little toxic and side effects on humans. DETAILED DESCRIPTION

[0016] The following is a further detailed description of a pharmaceutical composition for treating hair loss and a preparation method thereof according to the present invention in conjunction with embodiments.

[0017] Example 1

[0018] A pharmaceutical composition for treating hair loss, comprising the following raw materials in parts by weight: 10g of bupleurum, 15g of angelica, 15g of raw rehmannia, 10g of peach kernel, 10g of safflower, 10g of chuanxiong, 10g of fructus aurantii, 10g of platycodon, 15g of achyranthes bidentata, 6g of liquorice, 10g of red peony root, and 6g of siler;

[0019] The preparation method of the pharmaceutical composition comprises the following steps:

[0020] Step 1) respectively taking Bupleurum, Chinese Angelica, Radix Rehmanniae, Carthamus tinctorius, Rhizoma Chuanxiong, Fructus Aurantii Immaturus, Platycodon grandiflorum, Achyranthes bidentata, Licorice, Radix Paeoniae Rubra, Saposhnikovia divaricata by weight and setting aside;

[0021] Step 2) taking peach kernels by weight and crushing the peach kernels for later use;

[0022] Step 3) Put the raw materials taken in step 1 and the crushed peach kernels into a container in sequence, and then add purified water, wherein the amount of purified water added should be 4 cm above the raw materials;

[0023] First, heat with high heat, and after boiling, continue to simmer with low heat for 40 minutes. After cooling, filter out the liquid medicine to obtain the initial liquid medicine.

[0024] Step 4) Add the obtained initial drug solution into 2 liters of pure water, heat it again with high heat, boil it for 1 minute, then simmer it with low heat for 3 hours, and obtain the target product after cooling.

[0025] Example 2

[0026] In order to verify the therapeutic effect of the pharmaceutical composition obtained in Example 1, clinical observation was conducted on 15 patients with hair loss who came to the clinic for treatment.

[0027] 1. Diagnostic criteria: Patients have severe hair loss or alopecia areata symptoms.

[0028] 2. Observation method: Compare the clinical symptoms before and after treatment.

[0029] 3. Dosage method: Use the pharmaceutical composition obtained in Example 1, and when it is heated to 45±3°C, wash your hair with it, soak the head skin in the liquid for 5-10 minutes, and massage. The frequency of medication is once every 3 days, and 15 days is a course of treatment. After the course of treatment, reexamine and compare the clinical manifestations before and after treatment.

[0030] 4. Criteria for determining efficacy:

[0031] 1) Cure: clinical symptoms disappear;

[0032] 2) Marked effect: clinical symptoms partially disappear;

[0033] 3) Ineffective: No significant improvement in clinical symptoms.

[0034] 5. Observation conclusion:

[0035] Among the 15 patients, 8 were cured, with a cure rate of 53%; 5 were markedly effective, accounting for 30% of the total treated population; and 2 were ineffective, accounting for 13% of the treated population.

[0036] Example 3 Typical Cases

[0037] 1) Mr. Li, male, 20 years old, suffered from hair loss for a long time. After coming to the doctor for treatment, he adopted the pharmaceutical composition obtained in Example 1 and used it according to the doctor's advice. After two courses of treatment, his symptoms were relieved and new hair grew, with obvious effects.

[0038] The present invention and its implementation methods are described above, and such description is not restrictive. In short, if ordinary technicians in the field are inspired by it, without departing from the purpose of the invention, they can design structures and embodiments similar to the technical solution without creativity, which should all fall within the protection scope of the present invention.

Claims

1. A pharmaceutical composition for treating hair loss, characterized in that: The pharmaceutical composition comprises the following raw materials in parts by weight: 7-13g of bupleurum, 11-19g of angelica, 13-18g of raw rehmannia, 7-13g of peach kernel, 7-14g of safflower, 8-13g of chuanxiong, 9-11g of fructus aurantii, 7-13g of platycodon, 11-18g of achyranthes bidentata, 3-8g of liquorice, 6-13g of red peony root, and 5-8g of siler.

2. The pharmaceutical composition according to claim 1, characterized in that The pharmaceutical composition comprises the following raw materials in parts by weight: 10g of bupleurum, 15g of angelica, 15g of raw rehmannia, 10g of peach kernel, 10g of safflower, 10g of chuanxiong, 10g of fructus aurantii, 10g of platycodon, 15g of achyranthes bidentata, 6g of liquorice, 10g of red peony root, and 6g of siler.

3. The pharmaceutical composition according to claim 1, characterized in that The pharmaceutical composition comprises the following raw materials in parts by weight: 9g of bupleurum, 11g of angelica, 15g of raw rehmannia, 11g of peach kernel, 11g of safflower, 9g of chuanxiong, 9g of fructus aurantii, 13g of platycodon, 15g of achyranthes bidentata, 5g of liquorice, 9g of red peony root and 7g of siler.

4. The method for preparing the pharmaceutical composition according to any one of claims 1 to 3, characterized in that: The following steps are involved: Step 1) respectively taking Bupleurum, Chinese Angelica, Radix Rehmanniae, Carthamus tinctorius, Rhizoma Chuanxiong, Fructus Aurantii Immaturus, Platycodon grandiflorum, Achyranthes bidentata, Licorice, Radix Paeoniae Rubra, Saposhnikovia divaricata by weight and setting aside; Step 2) taking peach kernels by weight and crushing the peach kernels for later use; Step 3) Put the raw materials obtained in step 1 and the crushed peach kernel into a container in sequence, then add purified water, first heat with high heat, and after boiling, continue to simmer for 40 minutes with low heat, filter out the medicinal solution after cooling, and obtain the initial medicinal solution; Step 4) Add the obtained initial drug solution into purified water, heat it again with high heat, boil it for 1 minute, then simmer it with low heat for 2.5-3.5 hours, and obtain the target product after cooling.

5. The method for preparing the pharmaceutical composition according to claim 4, characterized in that: The amount of pure water added in step 3 needs to cover the raw materials by 3-5 cm.

6. The method for preparing the pharmaceutical composition according to claim 4, characterized in that: In step 4, the amount of pure water added is 1.8-2.1 liters.