Composition of high-concentration salicylic acid and preparation method thereof

Abstract

The invention provides a high-concentration salicylic acid composition, which is prepared from the following raw materials in parts by weight: 30 to 40 parts of high-concentration salicylic acid, 30 to 40 parts of polyethylene glycol-400, 10 to 20 parts of polyhydric alcohol, 2 to 5 parts of bisabolol, 2 to 5 parts of dipotassium glycyrrhizinate and 2 to 5 parts of anti-allergic agent, and the sum of the weight parts of all the components is 100. According to the composition of the high-concentration salicylic acid provided by the scheme, all the components are synergistically matched, multi-dimensional synergistic interaction is achieved through a prebiotic system, the skin barrier is consolidated, the metabolism capacity of the skin is improved, the skin is relieved and repaired, and research shows that microorganisms play a key role in inflammatory skin pathogenesis.

Description

Technical Field

[0001] The invention belongs to the technical field of cosmetics and skin care, and particularly relates to a high-concentration salicylic acid composition and a preparation method thereof. Background Art

[0002] Nowadays, the fast-paced lifestyle, irregular daily routine, and environmental pollution have led to an increasing number of people with acne-prone skin, and skin problems have become the focus of modern people's attention. Among them, acne and pimples not only affect skin and mental health, bring about appearance anxiety, but also have many impacts on life.

[0003] For this group of people, improving skin blemishes is a rigid demand. They have a more urgent demand for treatment and beauty, and are motivated to actively try various projects to solve skin problems. The anti-acne skin care market has huge space, and the "acid" ingredients and anti-inflammatory repair related to its treatment have become new drivers. The main idea for improving acne and closed comedones is to dredge them, among which acid ingredients have significant effects in dredging pores and controlling oil.

[0004] Salicylic acid is a classic beta-hydroxy acid (BHA) that is popular because it can penetrate deep into the pores, promote the metabolism of the stratum corneum, effectively remove dead skin cells, reduce pore blockage, and thus improve acne problems. However, traditional salicylic acid is added in low amounts, is highly irritating, and takes a long time to take effect. Summary of the invention

[0005] The purpose of the embodiments of this specification is to provide a high-concentration salicylic acid composition and a preparation method thereof, which can effectively remove acne and gently lighten marks. Through scientific proportions and special preparation processes, it can reduce skin irritation and improve the comfort and effect of use.

[0006] To solve the above technical problems, the embodiments of the present application are implemented in the following ways:

[0007] In a first aspect, the present application provides a high-concentration salicylic acid composition, comprising, by weight, the following raw materials:

[0008] 30-40 parts of high-concentration salicylic acid, 30-40 parts of polyethylene glycol-400, 10-20 parts of polyol, 2-5 parts of bisabolol, 2-5 parts of dipotassium glycyrrhizinate, 2-5 parts of anti-allergic agent, and the total weight of each component is 100 parts.

[0009] In one embodiment, the anti-allergic agent is one of ginger root extract, chamomile extract, and sea fennel extract.

[0010] In one embodiment, the high concentration of salicylic acid is salicylic acid with a concentration > 2%.

[0011] In a second aspect, the present application provides a method for preparing a high-concentration salicylic acid composition according to the first aspect, the method comprising:

[0012] Weigh the raw materials according to the weight ratio;

[0013] The high-concentration salicylic acid is subjected to low-temperature ultrasonic dispersion treatment to obtain treated salicylic acid;

[0014] The treated salicylic acid, polyethylene glycol-400 and polyol are mixed evenly, heated to 80-85°C, stirred and cooled to 70-75°C to obtain a first material body;

[0015] Add dipotassium glycyrrhizinate to the first material, stir evenly and cool to 40-45° C. to obtain a second material;

[0016] Adding bisabolol and an anti-allergic agent to the second material body and stirring evenly to obtain a third material body;

[0017] When the temperature of the third material body is lowered to 35° C., the cooling is stopped, and samples are taken for physical and chemical testing. If the test is qualified, a composition with high concentration of salicylic acid is obtained.

[0018] In one embodiment, the treated salicylic acid, polyethylene glycol-400, and polyol are mixed uniformly, including: fully mixing using ultrasonic dispersion technology.

[0019] In one embodiment, the temperature is lowered to 70-75° C. under stirring, and the stirring speed of the first material is 30-60 rpm.

[0020] It can be seen from the technical solutions provided in the embodiments of this specification that the high-concentration salicylic acid composition provided by the solution has synergistic combinations of components, and utilizes the multi-dimensional synergistic enhancement of the prebiotic system to consolidate the skin barrier, improve the skin's metabolic capacity, soothe and repair the skin. Studies have shown that microorganisms play a key role in the pathogenesis of inflammatory skin. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the embodiments of this specification or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in this specification. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative labor.

[0022] Figure 1 The present invention provides a schematic flow chart of a method for preparing a high-concentration salicylic acid composition. DETAILED DESCRIPTION

[0023] In order to enable those skilled in the art to better understand the technical solutions in this specification, the technical solutions in the embodiments of this specification will be clearly and completely described below in conjunction with the drawings in the embodiments of this specification. Obviously, the described embodiments are only part of the embodiments of this specification, not all of the embodiments. Based on the embodiments in this specification, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of this specification.

[0024] In the following description, specific details such as specific system structures, technologies, etc. are provided for the purpose of illustration rather than limitation, so as to provide a thorough understanding of the embodiments of the present application. However, it should be clear to those skilled in the art that the present application may also be implemented in other embodiments without these specific details. In other cases, detailed descriptions of well-known systems, devices, circuits, and methods are omitted to prevent unnecessary details from obstructing the description of the present application.

[0025] It will be apparent to those skilled in the art that various modifications and variations may be made to the specific embodiments of the present application description without departing from the scope or spirit of the present application. Other embodiments derived from the present application description will be apparent to those skilled in the art. The present application description and examples are exemplary only.

[0026] The words “include,” “including,” “have,” “contain,” etc. used in this document are open-ended terms, meaning including but not limited to.

[0027] The microecology on the surface of the skin is the first skin barrier between the skin and the external environment. The components in the high-concentration salicylic acid composition provided in this application are coordinated and use the prebiotic system to synergize in multiple dimensions to strengthen the skin barrier, improve the skin's metabolic capacity, soothe and repair the skin. Studies have shown that microorganisms play a key role in the pathogenesis of inflammatory skin.

[0028] The present invention is further described in detail below with reference to the accompanying drawings and embodiments.

[0029] The present application embodiment provides a high concentration salicylic acid composition, which comprises, in parts by weight, the following raw materials:

[0030] 30-40 parts of high-concentration salicylic acid, 30-40 parts of polyethylene glycol-400, 10-20 parts of polyol, 2-5 parts of bisabolol, 2-5 parts of dipotassium glycyrrhizinate, 2-5 parts of anti-allergic agent, and the total weight of each component is 100 parts.

[0031] Among them, the anti-allergic agent is one of ginger root extract, chamomile extract and sea fennel extract.

[0032] Specifically, the high-concentration salicylic acid is salicylic acid with a concentration of >2%. The high-concentration salicylic acid is the core component of the high-concentration salicylic acid composition provided by the present application, and is specially treated, ie, low-temperature ultrasonic dispersion treatment, to reduce irritation and maintain the best penetration effect.

[0033] Bisabolol, dipotassium glycyrrhizinate and ginger root extract or chamomile extract or sea fennel extract are the soothing ingredients of the high-concentration salicylic acid composition provided in the present application, which can effectively soothe skin inflammation and reduce redness, swelling and discomfort.

[0034] Polyols are the moisturizing ingredients of the high-concentration salicylic acid composition provided in this application, which can deeply hydrate the skin and promote skin barrier repair.

[0035] Macrogol-400 is a stabilizer for the high-concentration salicylic acid composition provided in the present application, which can ensure the stability and safety of the product.

[0036] Example 1

[0037] A method for preparing a high-concentration salicylic acid composition comprises the following steps:

[0038] Step 1. Weigh the raw materials according to weight ratio: 40 parts of high concentration salicylic acid, 40 parts of polyethylene glycol-400, 12 parts of polyol, 3 parts of bisabolol, 2 parts of dipotassium glycyrrhizinate, and 3 parts of ginger root extract.

[0039] Step 2: subjecting the high-concentration salicylic acid to low-temperature ultrasonic dispersion treatment to obtain treated salicylic acid.

[0040] Specifically, subjecting high-concentration salicylic acid to a low-temperature ultrasonic dispersion treatment can reduce the irritation of high-concentration salicylic acid to the skin and maintain the best penetration effect.

[0041] Step 3: Evenly mix the treated salicylic acid, polyethylene glycol-400 and polyol, and use ultrasonic dispersion technology to fully mix them, heat them to 80-85° C., stir and cool them to 70-75° C., and obtain a first material body.

[0042] Specifically, ultrasonic dispersion technology can be used at low temperature to fully disperse the mixture and reduce the granularity. The temperature is raised and the stirring speed of the mixture is controlled to fully dissolve the salicylic acid. The stirring speed can be 30-60 rpm.

[0043] Step 4: Add dipotassium glycyrrhizinate to the first material, stir evenly, and cool to 40-45° C. to obtain a second material.

[0044] Specifically, stirring is performed to completely dissolve the added dipotassium glycyrrhizinate.

[0045] Step 5: Add bisabolol and ginger root extract to the second material, stir evenly, and obtain a third material.

[0046] Specifically, the addition of bisabolol and ginger root extract helps not reduce the effect of the composition, ensuring that the high-concentration salicylic acid composition can effectively eliminate acne and fade acne marks. The effective active ingredients in the composition are scientifically proportioned and work synergistically.

[0047] Step 6: When the temperature of the third material body is lowered to 35° C., the cooling is stopped, and samples are taken for physical and chemical testing. If the test is qualified, a composition with high concentration of salicylic acid is obtained.

[0048] It is understandable that if the inspection fails, the problem will be found and a solution will be found.

[0049] Example 2

[0050] A method for preparing a high-concentration salicylic acid composition comprises the following steps:

[0051] Step 1. Weigh the raw materials in proportion by weight: 35 parts of high concentration salicylic acid, 35 parts of polyethylene glycol-400, 20 parts of polyol, 3 parts of bisabolol, 2 parts of dipotassium glycyrrhizinate, and 5 parts of chamomile extract.

[0052] Step 2: subjecting the high-concentration salicylic acid to low-temperature ultrasonic dispersion treatment to obtain treated salicylic acid.

[0053] Step 3: Evenly mix the treated salicylic acid, polyethylene glycol-400 and polyol, and use ultrasonic dispersion technology to fully mix them, heat them to 80-85° C., stir and cool them to 70-75° C., and obtain a first material body.

[0054] Step 4: Add dipotassium glycyrrhizinate to the first material, stir evenly, and cool to 40-45° C. to obtain a second material.

[0055] Step 5: Add bisabolol and chamomile extract to the second material body, stir evenly, and obtain a third material body.

[0056] Step 6: When the temperature of the third material body is lowered to 35° C., the cooling is stopped, and samples are taken for physical and chemical testing. If the test is qualified, a composition with high concentration of salicylic acid is obtained.

[0057] Example 3

[0058] A method for preparing a high-concentration salicylic acid composition comprises the following steps:

[0059] Step 1. Weigh the raw materials according to weight ratio: 38 parts of high concentration salicylic acid, 37 parts of polyethylene glycol-400, 15 parts of polyol, 3 parts of bisabolol, 2 parts of dipotassium glycyrrhizinate, and 5 parts of sea fennel extract.

[0060] Step 2: subjecting the high-concentration salicylic acid to low-temperature ultrasonic dispersion treatment to obtain treated salicylic acid.

[0061] Step 3: Evenly mix the treated salicylic acid, polyethylene glycol-400 and polyol, and use ultrasonic dispersion technology to fully mix them, heat them to 80-85° C., stir and cool them to 70-75° C., and obtain a first material body.

[0062] Step 4: Add dipotassium glycyrrhizinate to the first material, stir evenly, and cool to 40-45° C. to obtain a second material.

[0063] Step 5: Add bisabolol and sea fennel extract to the second material body, stir evenly, and obtain a third material body.

[0064] Step 6: When the temperature of the third material body is lowered to 35° C., the cooling is stopped, and samples are taken for physical and chemical testing. If the test is qualified, a composition with high concentration of salicylic acid is obtained.

[0065] Example 4

[0066] A method for preparing a high-concentration salicylic acid composition comprises the following steps:

[0067] Step 1. Weigh the raw materials according to weight ratio: 40 parts of high concentration salicylic acid, 40 parts of polyethylene glycol-400, 10 parts of polyol, 5 parts of bisabolol, 3 parts of dipotassium glycyrrhizinate, and 2 parts of ginger root extract.

[0068] Step 2: subjecting the high-concentration salicylic acid to low-temperature ultrasonic dispersion treatment to obtain treated salicylic acid.

[0069] Step 3: Evenly mix the treated salicylic acid, polyethylene glycol-400 and polyol, and use ultrasonic dispersion technology to fully mix them, heat them to 80-85° C., stir and cool them to 70-75° C., and obtain a first material body.

[0070] Step 4: Add dipotassium glycyrrhizinate to the first material, stir evenly, and cool to 40-45° C. to obtain a second material.

[0071] Step 5: Add bisabolol and ginger root extract to the second material, stir evenly, and obtain a third material.

[0072] Step 6: When the temperature of the third material body is lowered to 35° C., the cooling is stopped, and samples are taken for physical and chemical testing. If the test is qualified, a composition with high concentration of salicylic acid is obtained.

[0073] Example 5

[0074] A method for preparing a high-concentration salicylic acid composition comprises the following steps:

[0075] Step 1. Weigh the raw materials in proportion by weight: 38 parts of high concentration salicylic acid, 30 parts of polyethylene glycol-400, 20 parts of polyol, 2 parts of bisabolol, 5 parts of dipotassium glycyrrhizinate, and 5 parts of chamomile extract.

[0076] Step 2: subjecting the high-concentration salicylic acid to low-temperature ultrasonic dispersion treatment to obtain treated salicylic acid.

[0077] Step 3: Evenly mix the treated salicylic acid, polyethylene glycol-400 and polyol, and use ultrasonic dispersion technology to fully mix them, heat them to 80-85° C., stir and cool them to 70-75° C., and obtain a first material body.

[0078] Step 4: Add dipotassium glycyrrhizinate to the first material, stir evenly, and cool to 40-45° C. to obtain a second material.

[0079] Step 5: Add bisabolol and chamomile extract to the second material, stir evenly, and obtain a third material.

[0080] Step 6: When the temperature of the third material body is lowered to 35° C., the cooling is stopped, and samples are taken for physical and chemical testing. If the test is qualified, a composition with high concentration of salicylic acid is obtained.

[0081] Example 6

[0082] A method for preparing a high-concentration salicylic acid composition comprises the following steps:

[0083] Step 1. Weigh the raw materials according to weight ratio: 30 parts of high concentration salicylic acid, 37 parts of polyethylene glycol-400, 20 parts of polyol, 5 parts of bisabolol, 5 parts of dipotassium glycyrrhizinate, and 3 parts of sea fennel extract.

[0084] Step 2: subjecting the high-concentration salicylic acid to low-temperature ultrasonic dispersion treatment to obtain treated salicylic acid.

[0085] Step 3: Evenly mix the treated salicylic acid, polyethylene glycol-400 and polyol, and use ultrasonic dispersion technology to fully mix them, heat them to 80-85° C., stir and cool them to 70-75° C., and obtain a first material body.

[0086] Step 4: Add dipotassium glycyrrhizinate to the first material, stir evenly, and cool to 40-45° C. to obtain a second material.

[0087] Step 5: Add bisabolol and sea fennel extract to the second material, stir evenly, and obtain a third material.

[0088] Step 6: When the temperature of the third material body is lowered to 35° C., the cooling is stopped, and samples are taken for physical and chemical testing. If the test is qualified, a composition with high concentration of salicylic acid is obtained.

[0089] Experimental data

[0090] 1. Detection method

[0091] 30 healthy male / female subjects were selected, with an age range of 18-60 years old and an average age of 34.3 years old, including 5 males and 25 females. A before-and-after control method was used, before using the product and after using the product for 28 days, using the subject self-evaluation questionnaire method and human efficacy experimental data to provide a basis for the efficacy of the product.

[0092] 2. Evaluation process

[0093] Base value (D0, before using the product)

[0094] 1) Check in at the front desk (verify identity information);

[0095] 2) When the subjects come to visit, they will be asked a series of questions about their medical history and health status according to the inclusion and exclusion criteria. At the same time, the skin condition of the test site will be evaluated and screened and recorded;

[0096] 3) Cleaning the face and waiting: The subjects cleaned their faces with a facial cleanser, dried their skin with dry facial tissue, and sat quietly in a laboratory at 21±1°C and 50±10%RH for 30 minutes;

[0097] 4) Collection of basic facial data of test subjects: Laboratory technicians operate TEWL (used to test transepidermal water loss) and Sebumeter (used to test skin oil content) to measure relevant basic indicators on the cheeks of test subjects;

[0098] 5) The laboratory technician guides the subjects to use the product according to the test requirements and product usage methods, and provides written test precautions and product instructions. The laboratory technician performs on-site operations according to the product usage requirements and the use site, and applies the product to the subjects;

[0099] 6) The subject receives the sample and leaves the laboratory, and the testing process ends.

[0100] Day 28 (D28, 28 days after using the product)

[0101] 1) The subjects returned for a visit, cleansed their faces with facial cleansing products, dried their skin with dry facial tissues, and sat in a laboratory at 21±1℃ and 50±10%RH for 30 minutes;

[0102] 2) Subjects completed the Day28 self-assessment questionnaire while sitting quietly for 30 minutes;

[0103] 3) Data collection of the test subjects' skin on Day 28: Laboratory technicians used TEWL and Sebumeter instruments to measure the relevant basic value indicators on the subjects' cheeks;

[0104] 4) Laboratory technicians check subject compliance;

[0105] 5) The subject signs out at the front desk and leaves the laboratory.

[0106] 3. Evaluation results

[0107] 1) Recruit 31 patients with facial acne, blackheads, and facial skin with skin oil content > 100 μg / cm 2 (Before cleaning) and the lactic acid sting test was positive for healthy male or female subjects, age range 18-60 years old. The before-and-after control method was adopted: before use of the product and after 28 days of use of the product. 30 healthy subjects were selected, and the transepidermal water loss values ​​of the 30 testers were tested before use and after 28 days of use. The test results are as follows: the transepidermal water loss rate decreased by 10.54%; at the same time, the skin oil content of the 30 testers was tested before use and after 28 days of use, and the skin oil content decreased by 12.68%. At the same time, the number of acne in the facial area of ​​the testers was counted, and the number of acne decreased by 34%. The decrease in transepidermal water loss rate indicates that the skin barrier function is enhanced, and the decrease in skin oil content indicates that the skin oil control effect is enhanced. At the same time, the number of acne has decreased significantly. It can be concluded that this product has good moisturizing, acne removal and oil control effects.

[0108] 2) Recruit 31 patients with facial acne, blackheads, and facial skin with skin oil content > 100 μg / cm 2 Healthy male or female subjects with positive lactic acid sting test (before cleaning), age range 18-60 years old. The before-after control method was adopted: before product use, after product use for 28 days. Finally, 30 people were included in the statistics, and a questionnaire survey was conducted after using the product according to the product usage method for 28 days: 100% of the testers believed that the skin was clean and not tight after using the product; 100% of the testers believed that the oiliness of the skin was alleviated after using the product; 93.3% of the testers believed that the skin acne became smaller after using the product; 100% of the testers believed that the skin was light, transparent and soft after using the product; 100% of the testers were satisfied with the skin effect after using the product.

[0109] The high-concentration salicylic acid composition provided in the embodiment of the present application is prepared by mixing polyethylene glycol-400, polyol and salicylic acid, fully dispersing them and reducing the granularity by ultrasonic dispersion technology at low temperature, heating and controlling the stirring speed of the mixture to fully dissolve the salicylic acid, and then adding dipotassium glycyrrhizinate to completely dissolve it, and then adding bisabolol and ginger root extract after cooling, which helps the effect of the composition not to be reduced, ensuring that the high-concentration salicylic acid composition can effectively remove acne and fade acne marks, and the effective active ingredients in the composition are scientifically proportioned and work synergistically. The high-concentration salicylic acid composition provided in the present application is suitable for various skin types, especially oily, mixed and acne-prone skin.

[0110] The high-concentration salicylic acid composition provided in the present application achieves the dual effects of highly effective acne removal and mild scar lightening through scientific proportioning and special preparation technology, providing a new solution for the field of skin care.

[0111] It should be noted that the terms "include", "comprises" or any other variations thereof are intended to cover non-exclusive inclusion, so that a process, method, commodity or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, commodity or device. In the absence of further restrictions, the elements defined by the sentence "comprises a ..." do not exclude the existence of other identical elements in the process, method, commodity or device including the elements.

[0112] Each embodiment in this specification is described in a progressive manner, and the same or similar parts between the embodiments can be referred to each other, and each embodiment focuses on the differences from other embodiments. In particular, for the system embodiment, since it is basically similar to the method embodiment, the description is relatively simple, and the relevant parts can be referred to the partial description of the method embodiment.

Claims

1. A high concentration salicylic acid composition, characterized in that: Raw materials in parts by weight include: 30-40 parts of high-concentration salicylic acid, 30-40 parts of polyethylene glycol-400, 10-20 parts of polyol, 2-5 parts of bisabolol, 2-5 parts of dipotassium glycyrrhizinate, 2-5 parts of anti-allergic agent, and the total weight of each component is 100 parts.

2. The high concentration salicylic acid composition according to claim 1, characterized in that: The anti-allergic agent is one of ginger root extract, chamomile extract and sea fennel extract.

3. The high concentration salicylic acid composition according to claim 1, characterized in that: The high concentration salicylic acid is salicylic acid with a concentration greater than 2%.

4. A method for preparing a high concentration salicylic acid composition as claimed in any one of claims 1 to 3, characterized in that: The method comprises: Weigh the raw materials according to weight ratio; The high-concentration salicylic acid is subjected to low-temperature ultrasonic dispersion treatment to obtain treated salicylic acid; The treated salicylic acid, polyethylene glycol-400 and polyol are mixed evenly, heated to 80-85°C, stirred and cooled to 70-75°C to obtain a first material body; Add dipotassium glycyrrhizinate to the first material, stir evenly and cool to 40-45° C. to obtain a second material; Adding bisabolol and an anti-allergic agent to the second material body and stirring evenly to obtain a third material body; When the temperature of the third material body is lowered to 35° C., the cooling is stopped, and samples are taken for physical and chemical testing. If the test is qualified, a composition with high concentration of salicylic acid is obtained.

5. The preparation method according to claim 4, characterized in that: The step of uniformly mixing the treated salicylic acid, polyethylene glycol-400 and polyol comprises: fully mixing by using ultrasonic dispersion technology.

6. The preparation method according to claim 4, characterized in that: The stirring is performed while cooling the temperature to 70-75° C., and the stirring speed of the first material body is 30-60 rpm.

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