Fungicide composition

Abstract

The present disclosure relates to a fungicide composition. More specifically, the present disclosure relates to a liquid fungicide composition comprising a combination of a benzamide based fungicide and a surfactant. The present disclosure also relates to a method for preparing the fungicide composition and a method for controlling the growth of a fungal plant pathogen using the fungicide composition.

Description

Technical field:

[0001] The present disclosure relates to an agrochemical composition for crop protection. The present disclosure also relates to a method for preparing the composition.

[0002] Background technology of the present disclosure:

[0003] Crop protection agrochemical compositions can be formulated in different ways, and the characteristics of the active ingredients and the properties of the formulation may cause problems in terms of the ease of formulation, stability, ease of application and activity of the formulation. In addition, some formulations are more advantageous than others for economic and ecological reasons.

[0004] Therefore, highly concentrated active ingredient formulations are desirable because they offer many advantages. For example, highly concentrated formulations require less packaging costs and complexity than less concentrated formulations. As a result, the costs and complexity of production, transportation and storage are reduced, and in addition, the preparation of spray solutions used in agriculture is simplified, such as during the dispensing and mixing operations, due to the handling of small-volume containers of crop protection compositions.

[0005] The advantage of liquid formulations over powder formulations is that they do not generate dust when the spray liquid is reconstituted (usually by adding water). Suspension concentrates are preferred liquid formulations because they are concentrated. Suspension concentrates refer to suspensions of solid particulate active ingredients in liquids that must be diluted with water before use. Suspension concentrates were developed primarily because they have a variety of advantages over other formulations, such as no dust generation, reduced toxicity and flammability due to solvents, and higher efficiency due to smaller particle size and small packaging volume. However, problems with suspension concentrate formulations such as low surface tension, foaming, and low pH still exist. When applied to crops, the acidity or low pH of suspension concentrates can adversely affect the soil and destroy the appearance of crops, thereby affecting the yield of agricultural products. Lower pH values ​​can also affect the half-life of the active ingredients in the formulation, leading to their degradation.

[0006] Zoxanil is a benzamide fungicide that is very effective against oomycete pathogens. This fungicide disrupts the microtubule cytoskeleton by binding to β-tubulin. It is currently widely used in potatoes, vine crops and other vegetable crops.

[0007] However, there is a need in the art to develop a stable bezobactam preparation to overcome the disadvantages of the known preparations and have excellent efficacy. There is also a need in the art to provide a bezobactam suspension concentrate preparation with a neutral pH value and low surface tension, which preparation has stability.

[0008] Purpose of this Disclosure

[0009] The main object of the present disclosure is to provide a stable liquid fungicide composition comprising a benzamide fungicide.

[0010] Another object of the present disclosure is to provide a stable liquid composition which effectively retains the active ingredient and improves suspensibility.

[0011] Another object of the present disclosure is to provide a stable liquid composition having high antifungal activity against plant pathogens.

[0012] Another object of the present disclosure is to provide a stable suspension concentrate composition which does not form foam, has a high pH value and better visual appearance of the formulation.

[0013] Summary of the invention disclosed herein:

[0014] The present disclosure provides a fungicide composition comprising a benzamide fungicide and a combination comprising a surfactant, wherein the surfactant comprises an anionic surfactant and a nonionic surfactant.

[0015] The present disclosure provides a suspension concentrate (SC) composition comprising zoxamidopropynil and a combination of a surfactant comprising an anionic surfactant and a nonionic surfactant.

[0016] In one aspect, the present disclosure provides a suspension concentrate composition comprising zoxamidopropynil and a combination of a surfactant comprising an anionic surfactant and a nonionic surfactant, wherein the weight ratio of the anionic surfactant to the nonionic surfactant ranges from about 20:1 to about 1:20.

[0017] In one aspect, the present disclosure provides a suspension concentrate composition comprising bezoxamide and a combination of a surfactant comprising an anionic surfactant and a nonionic surfactant, wherein the weight ratio of the anionic surfactant to the nonionic surfactant ranges from about 15:1 to about 1:15.

[0018] In another aspect, the present disclosure provides use of the fungicide composition for controlling plant pathogenic fungi.

[0019] In one aspect, the present disclosure provides a method of controlling plant pathogenic fungi, the method comprising contacting a plant, plant part, plant propagation material, pest, their food supply, habitat or breeding ground with a suspension concentrate composition comprising a combination of zoxamidin and a surfactant comprising an anionic surfactant and a nonionic surfactant.

[0020] In another aspect, the present disclosure provides a method for increasing crop yield, comprising applying the fungicide composition of the present disclosure to the surface of crops, or plant propagation materials or agricultural products.

[0021] In another aspect, the present disclosure provides a kit comprising a plurality of components, each of which may include at least one or more ingredients of the fungicide composition of the present disclosure.

[0022] Additional features and advantages of the present disclosure will be apparent from the following detailed description which shows the most preferred features of the present disclosure by way of example and which should not be construed as limiting the scope of the disclosure described herein.

[0023] Specific embodiments of the present disclosure

[0024] The following description is provided to assist in a comprehensive understanding of the exemplary embodiments of the present disclosure. It includes various specific details to assist in understanding, but these are considered to be exemplary only. Therefore, those of ordinary skill in the art will recognize that various changes and modifications may be made to the embodiments described herein without departing from the scope of the present disclosure. In addition, for clarity and conciseness, descriptions of well-known functions and structures are omitted.

[0025] The terms used in the following description and claims are not limited to the bibliographical meanings, but are used only by the inventors to enable a clear and consistent understanding of the present disclosure. Therefore, it should be clear to those skilled in the art that the following description of exemplary embodiments of the present disclosure is provided for illustration only and is not intended to limit the scope of the present disclosure as defined by the appended claims and their equivalents.

[0026] For the purpose of this disclosure, it should be understood that the present disclosure can take various alternative variations and step sequences, unless there is a clear contrary provision. In addition, except in any operating examples or otherwise specified, all numbers representing the amount of materials / ingredients used in the specification should be understood to be modified by the term "about" in all cases.

[0027] Therefore, before describing the present disclosure in detail, it should be understood that the present disclosure is not limited to the systems or process parameters specifically exemplified, which may of course vary. It should also be understood that the terms used herein are only used to describe embodiments of the present disclosure and are not intended to limit the scope of the present disclosure in any way. The use of examples anywhere in this specification (including examples of any term discussed herein) is illustrative only and in no way limits the scope and meaning of the present disclosure or any exemplary term.

[0028] Before elaborating on this topic in detail, it may be helpful to provide definitions of certain terms used herein. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which this topic belongs. For the sake of clarity, the following definitions are provided.

[0029] The use of the terms "a", "an", "the" and similar referents (especially in the context of the claims) should be interpreted to cover both the singular and the plural, unless otherwise indicated herein or clearly contradicted by the context. The terms first, second, etc. used herein are not meant to indicate any order, but are only for convenience to indicate a plurality, such as layers.

[0030] The terms "comprising," "having," "including," and "containing" should be construed as open-ended terms (ie, meaning "including, but not limited to,") unless otherwise noted.

[0031] Taking into account the measurement in question and the errors associated with the measurement of a particular amount (i.e., the limitations of the measurement system), "about" or "approximately" as used herein includes the stated value and the average value within the acceptable deviation range of the particular value determined by those skilled in the art. For example, "about" can be expressed as within one or more standard deviations, or within ±10% or ±5% of the stated value. Unless otherwise specified herein, the description of the range of values ​​is intended only as a shorthand method to individually reference each individual value falling within the range, and each individual value is incorporated into the specification as if it were individually described herein. The endpoints of all ranges are included in the range and can be independently combined. It should be understood that where a parameter range is provided, all integers and tenths thereof within the range are also provided. For example, "0.1-80%" includes 0.1%, 0.2%, 0.3%, etc. up to 80%.

[0032] All methods described herein can be performed in a suitable order unless otherwise stated herein or clearly contradicted by context. Unless otherwise stated, the use of any and all examples or exemplary language (e.g., "such as") is intended only to better illustrate the present disclosure and does not limit the scope of the present disclosure. No language used in the specification should be construed to indicate that any element not set forth in the claims is essential to the practice of the present disclosure.

[0033] As used herein, the term "agrochemical" is understood to mean agricultural chemicals, such as pesticides, fungicides, insecticides, miticides, herbicides, nematicides, plant growth regulators, and can be used interchangeably.

[0034] As used herein, the term "plant" or "crop" refers to a whole plant, a plant organ (e.g., leaves, stems, shoots, roots, trunks, branches, twigs, fruits, etc.), a plant cell or a plant seed. This term also includes plant crops, such as fruits. The term "plant" may also include "plant propagation material," which may include all reproductive parts of the plant, such as seeds and asexual plant materials, such as cuttings and tubers, which may be used for the propagation of the plant. This includes seeds, tubers, spores, corms, bulbs, rhizomes, buds, basal buds, runners and buds, as well as other parts of the plant, including rice seedlings and seedlings transplanted after germination or after emergence from the soil.

[0035] The term "site" as used herein means a vicinity or area designated for growing a desired crop susceptible or potentially susceptible to insect infestation, and where fungal control is desired. The site includes the vicinity of the desired crop plants where fungal infestation has occurred, is most likely to occur, or has not yet occurred.

[0036] The salts referred to herein are agriculturally acceptable salts. As used herein, "agriculturally acceptable salts" or "agrochemically acceptable salts" refer to salts that are known and accepted for agricultural or horticultural use.

[0037] The term "agriculturally acceptable amount of active substance" refers to the amount of active substance that kills or inhibits the pests / fungi that need to be controlled, and this amount has no significant toxicity to the treated plants. The common names of the active ingredients mentioned in this specification can be obtained from the 13th edition of the Handbook of Insecticides of the British Crop Protection Commission (2003), and can also be obtained from www.alanwood.net / pesticides get.

[0038] As used herein, the term "stable" refers to an active compound (eg, fungicide) that is chemically and / or physically stable over a certain time interval. The stability test described herein was performed according to the method of the International Pesticide Analysis Cooperative Committee (CIPAC).

[0039] The term "active" as used herein refers to a component that has chemical and / or biological activity. The term "active ingredient" as used herein refers to zoxamide or its salt or ester. In this regard, the "active" ingredient can be a single ingredient or a combination of multiple ingredients; and the meaning of the term "active" should be understood to include, but is not limited to, "benzamide fungicides" or zoxamide or its salt or ester.

[0040] Particle size is usually defined as the median diameter or D 50The term "particle size distribution" as used herein refers to the relative percentage by weight or volume of each different size fraction of a particulate material. The terms "median particle size", "median particle diameter", " D50 ” refers to the median or 50% quantile of the particle size distribution. Therefore, the term “D 50 ” defines a size where 50 volume percent of the particles are smaller than a given value.

[0041] Therefore, the term "D 90 ” defines a size where 90 volume percent of the particles are smaller than a given value.

[0042] The term "fungicide" refers to the ability of a substance to reduce or inhibit the growth of fungi or oomycetes.

[0043] "Control" or "controlling" fungi means inhibiting and / or suppressing the ability of fungi to grow and / or reproduce, or limiting fungus-related damage or loss in crop plants, or means controlling and preventing diseases. Control effects include all deviations from natural development, such as killing, delaying, reducing fungal diseases.

[0044] As used herein, "fungicidally effective amount" refers to an amount of active ingredient (eg, fungicide) that results in an adverse modification effect and includes deviation from natural development, killing, regulating, drying, delaying, and the like.

[0045] According to the present disclosure, "yield improvement" of an agricultural plant means that the yield of the corresponding plant product is increased by a measurable amount compared to the yield of the same plant product produced under the same conditions without the application of the present disclosure.

[0046] As used herein, the term "premix" refers to a preparation of more than one ingredient in a premixed formulation intended to be made into a mixture and applied to plants with or without further dilution with water.

[0047] As used herein, the term "gai / ha" means the concentration of the corresponding active ingredient in "grams" applied "per hectare" of crop field.

[0048] Each of the above aspects may have one or more embodiments. Each of the embodiments described below may be applicable to one or all of the aspects described above. These embodiments are intended to be interpreted as preferred features of one or all of the aspects described above. Each of the embodiments described below may be applicable to each of the aspects described above.

[0049] The inventors of the present disclosure have found that in fungicide compositions, especially suspension concentrate formulations, the stability of zoxamide is very good, there is no foam formation, the pH value is high, and the visual appearance of the formulation is better (especially when a combination of anionic and nonionic surfactants is used).

[0050] In one embodiment, the present disclosure provides an agricultural chemical composition.

[0051] Thus, in one embodiment, the present disclosure provides a fungicide composition.

[0052] Therefore, the present disclosure provides a fungicide composition comprising a benzamide fungicide.

[0053] In one embodiment, the benzamide fungicide is selected from the group consisting of benzohydroxamic acid, fluopyram, fluopyram, fluopyram, thiocyanate, salicylam, cyanamide, zoxamide, their salts, isomers or combinations thereof.

[0054] In a preferred embodiment, the benzamide fungicide is bezobactam.

[0055] In one embodiment, the benzamide fungicide is also known as a tubulin polymerizing fungicide.

[0056] In a preferred embodiment, bezoxamide is also known as a tubulin polymerizing fungicide.

[0057] Therefore, the present disclosure provides a fungicide composition comprising zoxamidin and at least one surfactant.

[0058] In one embodiment, the fungicide composition comprises zoxamidopropynil and at least one surfactant, the at least one surfactant comprising an anionic surfactant and a nonionic surfactant.

[0059] In one embodiment, the present disclosure provides a fungicide composition comprising zoxamidin and at least two surfactants.

[0060] In one embodiment, the fungicide composition comprises zoxamidopropynil and at least two surfactants, wherein the at least two surfactants comprise an anionic surfactant and a nonionic surfactant.

[0061] In one embodiment, the present disclosure provides a fungicide composition comprising a combination of zoxamidin and a surfactant.

[0062] In one embodiment, the fungicide composition comprises a combination of zoxamide and a surfactant, wherein the surfactant comprises an anionic surfactant and a nonionic surfactant.

[0063] In one embodiment, the present disclosure provides a fungicide composition comprising zoxamidin and a surfactant mixture.

[0064] In one embodiment, the fungicide composition comprises zoxamidopropynil and a surfactant mixture comprising an anionic surfactant and a nonionic surfactant.

[0065] Therefore, the present disclosure provides a fungicide composition comprising a benzamide fungicide, i.e., zoxamide, and a combination of a surfactant, comprising an anionic surfactant and a nonionic surfactant, for controlling plant pathogenic fungi and oomycetes.

[0066] According to one embodiment of the present disclosure, the fungicide composition comprises about 1% w / w to about 80% w / w of the benzamide fungicide based on the total weight of the composition.

[0067] In one embodiment of the present disclosure, the fungicide composition comprises about 1% w / w to about 60% w / w of the benzamide fungicide based on the total weight of the composition.

[0068] In one embodiment of the present disclosure, the fungicide composition comprises about 10% w / w to about 50% w / w of the benzamide fungicide based on the total weight of the composition.

[0069] In one embodiment of the present disclosure, the fungicide composition comprises about 10% w / w to about 40% w / w of the benzamide fungicide based on the total weight of the composition.

[0070] In a preferred embodiment, the fungicide composition comprises about 10% w / w to about 30% w / w of zoxamide based on the total weight of the composition.

[0071] In a preferred embodiment, the fungicide composition comprises about 22.5% w / w of zoxadiazole based on the total weight of the composition.

[0072] In a preferred embodiment, the fungicide composition comprises zoxamide at a concentration ranging from about 240 g / L to about 250 g / L.

[0073] According to one embodiment of the present disclosure, the surfactant is selected from the group consisting of anionic surfactants, nonionic surfactants or a combination thereof.

[0074] In one embodiment, the surfactant comprises an anionic surfactant and a nonionic surfactant.

[0075] In one embodiment, the anionic surfactant is a sulfonic acid surfactant.

[0076] In one embodiment, the sulfonic acid surfactant is selected from the group consisting of substituted and polymerized alkyl and aryl sulfonates, such as sodium alkylnaphthalene sulfonate, sodium naphthalene sulfonate, calcium lignin sulfonate, sodium lignin sulfonate, polysodium naphthalene sulfonate, ammonium lignin sulfonate, or combinations thereof.

[0077] In another embodiment, the anionic surfactant is a sulfonic acid surfactant selected from the group consisting of sodium alkylnaphthalene sulfonate, sodium naphthalene sulfonate, calcium lignin sulfonate, sodium lignin sulfonate, sodium polynaphthalene sulfonate and ammonium lignin sulfonate, or a combination thereof.

[0078] In a preferred embodiment, the sulfonic acid surfactant is sodium lignin sulfonate.

[0079] In a preferred embodiment, the anionic surfactant is sodium lignin sulfonate.

[0080] In one embodiment, the nonionic surfactant is an ethoxylated alcohol.

[0081] In one embodiment, the nonionic surfactant is an ethoxylated alcohol selected from the group consisting of alkylamine ethoxylates, acrylate graft copolymer ethoxylates, block polymers, carboxylated alcohol or alkylphenol ethoxylates, alcohol ethoxylates, ethoxylated alkylphenols, ethylene glycol esters, polyethylene glycols, silicone-based surfactants, tristyrylphenol ethoxylates, ethoxylated isotridecanols, or combinations thereof.

[0082] In one embodiment, the nonionic surfactant is an ethoxylate, and the ethoxylate is selected from the group consisting of alkylamine ethoxylates, alkylphenol ethoxylates, alcohol ethoxylates, tristyrylphenol ethoxylates, or combinations thereof.

[0083] In a preferred embodiment, the nonionic surfactant is ethoxylated isotridecanol.

[0084] In one embodiment, the surfactant is selected from one or more sulfonic acid surfactants and ethoxylated alcohols.

[0085] In one embodiment, the at least one surfactant is selected from sulfonic acid surfactants and ethoxylated alcohols.

[0086] In one embodiment, the at least two surfactants are selected from sulfonic acid surfactants and ethoxylated alcohols.

[0087] In one embodiment, the combination of surfactants is selected from a sulfonic acid surfactant and an ethoxylated alcohol.

[0088] In one embodiment, the surfactant mixture is selected from sulfonic acid surfactants and ethoxylated alcohols.

[0089] In one embodiment, the fungicide composition comprises a combination of surfactants in an amount of about 1% w / w to about 40% w / w based on the total weight of the composition.

[0090] In one embodiment, the fungicide composition comprises a combination of surfactants in an amount of about 1% w / w to about 20% w / w based on the total weight of the composition.

[0091] In one embodiment, the fungicide composition comprises from about 1% w / w to about 15% w / w of the surfactant combination based on the total weight of the composition.

[0092] In a preferred embodiment, the fungicide composition comprises about 10.07% w / w of the combination of surfactants based on the total weight of the composition.

[0093] In one embodiment, the fungicide composition comprises about 1% w / w to about 30% w / w of anionic surfactant based on the total weight of the composition.

[0094] In one embodiment, the fungicide composition comprises about 1% w / w to about 30% w / w of the sulfonic acid surfactant, based on the total weight of the composition.

[0095] In one embodiment, the fungicide composition comprises about 1% w / w to about 15% w / w of the sulfonic acid surfactant, based on the total weight of the composition.

[0096] In a preferred embodiment, the fungicide composition comprises about 8.95% w / w sodium lignin sulfonate based on the total weight of the composition.

[0097] In a preferred embodiment, the fungicide composition comprises sodium lignin sulfonate in a concentration range of about 75 g / L to about 130 g / L.

[0098] In one embodiment, the fungicide composition comprises about 0.5% w / w to about 20% w / w of the nonionic surfactant based on the total weight of the composition.

[0099] In one embodiment, the fungicide composition comprises about 0.5% w / w to about 20% w / w of the ethoxylated alcohol surfactant, based on the total weight of the composition.

[0100] In one embodiment, the fungicide composition comprises about 1% w / w to about 10% w / w of the ethoxylated alcohol surfactant, based on the total weight of the composition.

[0101] In a preferred embodiment, the fungicide composition comprises about 1.12% w / w of ethoxylated isotridecanol based on the total weight of the composition.

[0102] In a preferred embodiment, the fungicide composition comprises ethoxylated isotridecanol in a concentration ranging from about 7.5 g / L to about 15 g / L.

[0103] In a preferred embodiment, the composition comprises about 1% w / w to about 30% w / w of anionic surfactant based on the total weight of the composition, and about 0.5% w / w to about 20% w / w of nonionic surfactant based on the total weight of the composition.

[0104] In one embodiment, the present disclosure provides a fungicide composition comprising:

[0105] (a) benzamide fungicides; and

[0106] (b) at least one surfactant comprising an anionic surfactant and a nonionic surfactant;

[0107] The weight ratio of the anionic surfactant to the nonionic surfactant is in the range of about 20:1 to about 1:20.

[0108] In one embodiment, the present disclosure provides a fungicide composition comprising:

[0109] (a) benzamide fungicides; and

[0110] (b) at least two surfactants, the surfactants comprising an anionic surfactant and a nonionic surfactant;

[0111] The weight ratio of the anionic surfactant to the nonionic surfactant is in the range of about 20:1 to about 1:20.

[0112] In one embodiment, the present disclosure provides a fungicide composition comprising:

[0113] (a) benzamide fungicides; and

[0114] (b) a combination of surfactants comprising anionic surfactants and nonionic surfactants;

[0115] The weight ratio of the anionic surfactant to the nonionic surfactant is in the range of about 20:1 to about 1:20.

[0116] In one embodiment, the present disclosure provides a fungicide composition comprising:

[0117] (a) benzamide fungicides; and

[0118] (b) a surfactant mixture comprising an anionic surfactant and a nonionic surfactant;

[0119] The weight ratio of the anionic surfactant to the nonionic surfactant is in the range of about 20:1 to about 1:20.

[0120] In another embodiment, the weight ratio of anionic surfactant to nonionic surfactant is selected from 20: 1, 19: 1, 18: 1, 17: 1, 16: 1, 15: 1, 14: 1, 13: 1, 12: 1, 11: 1, 10: 1, 9: 1, 8: 1, 7: 1, 6: 1, 5: 1, 4: 1, 3: 1, 2: 1, 1: 1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:11, 1:12, 1:13, 1:14, 1:15, 1:16, 1:17, 1:18, 1:19, and 1:20.

[0121] In a preferred embodiment, the present disclosure provides a fungicide composition, the fungicide composition comprising:

[0122] (a) zoxadiazole; and

[0123] (b) a surfactant combination comprising a sulfonic acid surfactant and an ethoxylated alcohol;

[0124] The weight ratio of the sulfonic acid surfactant to the ethoxylated alcohol is in the range of about 15:1 to about 1:15.

[0125] In a preferred embodiment, the present disclosure provides a fungicide composition, the fungicide composition comprising:

[0126] (a) zoxadiazole; and

[0127] (b) a surfactant combination comprising sodium lignin sulfonate and ethoxylated isotridecanol;

[0128] The weight ratio of sodium lignin sulfonate to ethoxylated isotridecanol is about 8:1.

[0129] In a preferred embodiment, the present disclosure provides a fungicide composition, the fungicide composition comprising:

[0130] (a) zoxadiazole; and

[0131] (b) a surfactant combination comprising sodium lignin sulfonate and ethoxylated isotridecanol;

[0132] The weight ratio of sodium lignin sulfonate to ethoxylated isotridecanol is about 7.99:1.

[0133] In one embodiment, compositions useful for the present disclosure include solid and liquid-based compositions. Compositions disclosed herein can be formulated in a manner suitable for a particular application. The formulation can be a solid or liquid formulation. Non-limiting examples of suitable liquid formulations can be emulsion concentrates (EC), suspension concentrates (SC), capsule suspensions (CS), oil dispersions (OD); and suitable solid formulations can be water-dispersible granules (WDG) and wettable powders (WP), powders, etc.

[0134] In a preferred embodiment, the fungicide composition is a liquid composition.

[0135] In one embodiment, the fungicide composition is a liquid formulation.

[0136] In one embodiment, the fungicide composition is a suspension concentrate (SC) formulation.

[0137] In one embodiment, the present disclosure provides a suspension concentrate fungicide composition comprising:

[0138] (a) benzamide fungicides; and

[0139] (b) at least one surfactant, the surfactant comprising an anionic surfactant and a nonionic surfactant.

[0140] In one embodiment, the present disclosure provides a suspension concentrate fungicide composition comprising:

[0141] (a) benzamide fungicides; and

[0142] (b) at least two surfactants, the surfactants comprising an anionic surfactant and a nonionic surfactant.

[0143] In one embodiment, the present disclosure provides a suspension concentrate fungicide composition comprising:

[0144] (a) benzamide fungicides; and

[0145] (b) A combination of surfactants, the surfactant comprising an anionic surfactant and a nonionic surfactant.

[0146] In one embodiment, the present disclosure provides a suspension concentrate fungicide composition comprising:

[0147] (a) benzamide fungicides; and

[0148] (b) a surfactant mixture, the surfactant comprising an anionic surfactant and a nonionic surfactant.

[0149] In one embodiment, the present disclosure provides a suspension concentrate fungicide composition comprising:

[0150] (a) benzamide fungicides; and

[0151] (b) at least one surfactant comprising an anionic surfactant and a nonionic surfactant;

[0152] The weight ratio of the anionic surfactant to the nonionic surfactant is in the range of about 20:1 to about 1:20.

[0153] In one embodiment, the present disclosure provides a suspension concentrate fungicide composition comprising:

[0154] (a) benzamide fungicides; and

[0155] (b) at least two surfactants, the surfactants comprising an anionic surfactant and a nonionic surfactant;

[0156] The weight ratio of the anionic surfactant to the nonionic surfactant is in the range of about 20:1 to about 1:20.

[0157] In one embodiment, the present disclosure provides a suspension concentrate fungicide composition comprising:

[0158] (a) benzamide fungicides; and

[0159] (b) a combination of surfactants comprising anionic surfactants and nonionic surfactants;

[0160] The weight ratio of the anionic surfactant to the nonionic surfactant is in the range of about 20:1 to about 1:20.

[0161] In one embodiment, the present disclosure provides a suspension concentrate fungicide composition comprising:

[0162] (a) benzamide fungicides; and

[0163] (b) a surfactant mixture comprising an anionic surfactant and a nonionic surfactant;

[0164] The weight ratio of the anionic surfactant to the nonionic surfactant is in the range of about 20:1 to about 1:20.

[0165] In one embodiment, the present disclosure provides a suspension concentrate fungicide composition comprising:

[0166] (a) zoxadiazole; and

[0167] (b) A combination of surfactants, the surfactant comprising an anionic surfactant and a nonionic surfactant.

[0168] The weight ratio of the anionic surfactant to the nonionic surfactant is in the range of about 20:1 to about 1:20.

[0169] In a preferred embodiment, the present disclosure provides a suspension concentrate fungicide composition, the suspension concentrate fungicide composition comprising:

[0170] (a) zoxadiazole; and

[0171] (b) A combination of surfactants, the surfactant comprising an anionic surfactant and a nonionic surfactant.

[0172] The weight ratio of the anionic surfactant to the nonionic surfactant is in the range of about 15:1 to about 1:15.

[0173] In one embodiment, the present disclosure provides a suspension concentrate fungicide composition comprising:

[0174] (a) zoxadiazole; and

[0175] (b) a surfactant combination comprising a sulfonic acid surfactant and an ethoxylated alcohol;

[0176] The weight ratio of the sulfonic acid surfactant to the ethoxylated alcohol is in the range of about 20:1 to about 1:20.

[0177] In a preferred embodiment, the present disclosure provides a suspension concentrate (SC) fungicide composition, the suspension concentrate (SC) fungicide composition comprising:

[0178] (a) zoxadiazole; and

[0179] (b) a surfactant combination comprising a sulfonic acid surfactant and an ethoxylated alcohol;

[0180] The weight ratio of the sulfonic acid surfactant to the ethoxylated alcohol is in the range of about 15:1 to about 1:15.

[0181] In a preferred embodiment, the present disclosure provides a suspension concentrate composition comprising:

[0182] (a) zoxadiazole; and

[0183] (b) a surfactant combination comprising sodium lignin sulfonate and ethoxylated isotridecanol;

[0184] The weight ratio of sodium lignin sulfonate to ethoxylated isotridecanol is in the range of about 10:1 to about 1:10.

[0185] In a preferred embodiment, the present disclosure provides a suspension concentrate fungicide composition, the suspension concentrate fungicide composition comprising:

[0186] (a) zoxadiazole; and

[0187] (b) a surfactant combination comprising sodium lignin sulfonate and ethoxylated isotridecanol;

[0188] The weight ratio of sodium lignin sulfonate to ethoxylated isotridecanol is about 8:1.

[0189] In a preferred embodiment, the present disclosure provides a suspension concentrate fungicide composition, the suspension concentrate fungicide composition comprising:

[0190] (a) zoxadiazole; and

[0191] (b) a surfactant combination comprising sodium lignin sulfonate and ethoxylated isotridecanol;

[0192] The weight ratio of sodium lignin sulfonate to ethoxylated isotridecanol is about 7.99:1.

[0193] In one embodiment, the particle size distribution D of the active ingredient in the suspension concentrate fungicide composition is 50 Less than about 10 microns.

[0194] In one embodiment, the particle size distribution of the active ingredient in the suspension concentrate fungicide composition is D50 Less than about 5 microns.

[0195] In one embodiment, the particle size distribution of the active ingredient in the suspension concentrate fungicide composition is D90 Less than about 20 microns.

[0196] In one embodiment, the particle size distribution D of the active ingredient in the suspension concentrate fungicide composition is 90 Less than about 10 microns.

[0197] In one embodiment, the fungicide composition exhibits excellent suspensibility, better dispersibility, better uniformity and no sedimentation. In one embodiment, the suspension concentrate fungicide composition of the present disclosure is stable at room temperature for up to 4 months.

[0198] In one embodiment, the present disclosure provides a suspension concentrate fungicide composition comprising:

[0199] (a) Zoxanil;

[0200] (b) a combination of surfactants comprising anionic surfactants and nonionic surfactants; and

[0201] (c) at least one agrochemically acceptable excipient.

[0202] In a preferred embodiment, the present disclosure provides a suspension concentrate composition comprising:

[0203] (a) Zoxanil;

[0204] (b) a combination of surfactants comprising sodium lignin sulfonate and ethoxylated isotridecanol; and

[0205] (c) at least one agrochemically acceptable excipient;

[0206] The weight ratio of sodium lignin sulfonate to ethoxylated isotridecanol is in the range of about 10:1 to about 1:10.

[0207] In one embodiment, the present disclosure provides a suspension concentrate fungicide composition comprising:

[0208] (a) from about 10% to about 40% w / w of zoxadiazole;

[0209] (b) from about 1% to about 20% w / w of a combination of surfactants comprising anionic surfactants and nonionic surfactants; and

[0210] (c) at least one agrochemically acceptable excipient.

[0211] In one embodiment, the agrochemically acceptable excipient is selected from the group consisting of a wetting agent, a dispersant, a binder, an antifreeze agent, a surfactant, a preservative, a mineral, a colorant, a pH adjuster, a defoaming agent, a solvent, or a combination thereof. However, it should be understood that any other agrochemically acceptable excipient known to those skilled in the art can be used to achieve its intended purpose.

[0212] In one embodiment, the agrochemically acceptable excipient is present in an amount ranging from about 1% w / w to about 99% w / w of the total weight of the composition.

[0213] In one embodiment, the agrochemically acceptable excipient is present in an amount ranging from about 1% w / w to about 60% w / w of the total weight of the composition.

[0214] In one embodiment, the agrochemically acceptable excipient is present in an amount ranging from about 1% w / w to about 30% w / w of the total weight of the composition.

[0215] According to one embodiment, the wetting agent may include any one of sulfosuccinates, naphthalenesulfonates, olyoxypr esters, phosphates, olyoxypr alcohols, and alkylbenzenesulfonates, or a combination thereof, but is not limited thereto.

[0216] In one embodiment, the dispersant may include any one of polycarboxylates, naphthalenesulfonate condensates, phenolsulfonic acid condensates, lignin sulfonates, methyl oleyl taurate, and polyvinyl alcohol, or a combination thereof, but is not limited thereto.

[0217] In another embodiment, the binder may include any one of polyvinyl alcohol, phenylnaphthalene sulfonate, lignin derivatives, polyvinyl pyrrolidone, polyalkyl pyrrolidone, carboxymethyl cellulose, xanthan gum, polyethoxylated fatty acids, polyethoxylated fatty alcohols, ethylene oxide copolymers, propylene oxide copolymers, polyethylene glycol and polyethylene oxide, or a combination thereof, but is not limited thereto.

[0218] In one embodiment, the surfactant that can be included is selected from sulfonic acid, sulfate, carboxylic acid and its salt. Non-limiting examples of water-soluble anionic surfactants include alkyl sulfates, alkyl ether sulfates, alkyl amide ether sulfates, alkyl aryl polyether sulfates, alkyl aryl sulfates, alkyl aryl sulfonates, monoglyceride sulfates, alkyl sulfonates, alkyl amide sulfonates, alkyl aryl sulfonates, benzene sulfonates, toluene sulfonates, xylene sulfonates, cumene sulfonates, alkyl benzene sulfonates, alkyl diphenyl oxide sulfonates, alpha-olefin sulfonates, alkyl naphthalene sulfonates, paraffin sulfonates, lignin sulfonates, alkyl sulfosuccinates, ethoxylated sulfosuccinates, alkyl ether sulfosuccinates, alkyl amide sulfosuccinates, alkyl sulfosuccinamates, alkyl sulfoacetates, alkyl phosphates, phosphates, alkyl ether phosphates, acyl sarcosinates, acyl isethionates, N-acyl taurates, N-acyl-N-alkyl taurates and alkyl carboxylates. Non-limiting examples of nonionic surfactants include glycerol ethers, glycol ethers, ethanolamides, sulfonamides, alcohols, amides, alcohol ethoxylates, glycerides, glycol esters, ethoxylates of glycerides and glycol esters, glycosyl alkyl polyglycosides, polyoxyethylated fatty acids, alkanolamine condensates, alkanolamides, tertiary acetylenic diols, polyoxyethylated thiols, carboxylates, polyoxyethylated polyoxypropylene glycol, sorbitan fatty acid esters or combinations thereof. Also included are EO / PO block copolymers (EO is ethylene oxide, PO is propylene oxide), EO polymers and copolymers, polyamines, polyvinyl pyrrolidone, sorbitan fatty acid alcohol polyoxyethylene ethers, and sorbitan fatty acid ester polyoxyethylene ethers.

[0219] In one embodiment, the antifreeze agent may include any one or a combination of ethylene glycol, propylene glycol, urea, glycerol and antifreeze protein, but is not limited thereto. In one embodiment, the antifreeze compound is a glycol selected from ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, monopropylene glycol, dipropylene glycol, tripropylene glycol, glycerol and a mixture thereof.

[0220] In a preferred embodiment, the antifreeze compound is propylene glycol.

[0221] In a preferred embodiment, the antifreeze compound is monopropylene glycol.

[0222] In one embodiment, the mineral may include any one or a combination of kaolin, silica, titanium (IV) oxide, rutile, anatase, alumina, aluminum hydroxide, iron oxide, iron sulfide, magnetite, pyrite, hematite, ferrite, chlorite, calcium carbonate, calcite, aragonite, quartz, zircon, olivine, orthopyroxene, tourmaline, kyanite, albite, anorthite, monoclinic pyroxene, orthoclase, gypsum, andalusite, talc, fluorite, apatite, orthoclase, topaz, corundum, diamond, tin, tin oxide, antimony, antimony oxide, beryllium, cobalt, copper, feldspar, gallium, indium, lead, lithium, manganese, mica, molybdenum, nickel, perlite, platinum group metals, phosphorus and phosphate rocks, potash, rare earth elements, tantalum, tungsten, vanadium, zeolite, zinc and zinc oxide, and indium tin oxide, but is not limited thereto.

[0223] In one embodiment, the colorant may be selected from iron oxide, titanium oxide and Prussian blue, and organic dyes such as alizarin dyes, azo dyes or metal phthalocyanine dyes, and trace elements such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc or combinations thereof.

[0224] In one embodiment, defoamers suitable for the purposes of the present disclosure include, but are not limited to, silicone-based defoamers, such as; acetylene-based defoamers, and perfluoroalkyl phosphinic and phosphonic acids and their salts. Preferred defoamers are those from linear polydimethylsiloxanes, whose average dynamic viscosity measured at about 25°C is in the range of about 1000 to about 800 millipascal seconds (mPa.s), typically in the range of about 1200 to about 6000 mPa.s, and contain silicon dioxide. Silicon dioxide includes polysilicic acid, metasilicic acid, orthosilicic acid, silica gel, silica gel, diatomaceous earth, precipitated silica, and the like. Linear polydimethylsiloxane defoamers contain a chemical formula of HO-[Si(CH3)2-O-] n H compounds as their chemical backbone, wherein the terminal groups are modified (e.g. by etherification), or are attached to the group -Si(CH3)3. Particularly preferred are polydimethylsiloxanes, wherein two methyl groups are attached to each silicon atom to form (H3C)[SiO(CH3)2] n Si(CH3) and dimethicone, which is a mixture of polydimethylsiloxane and silicon dioxide.

[0225] In one embodiment, the present composition further comprises at least one buffer as a pH adjuster to maintain the pH value of the composition.

[0226] According to one embodiment, examples of suitable solvents are water, vegetable oils or derivatives. In principle, solvent mixtures can also be used.

[0227] According to one embodiment, the present disclosure provides a suspension concentrate fungicide composition, the suspension concentrate fungicide composition comprising:

[0228] (a) Benzamide fungicides;

[0229] (b) a combination of surfactants comprising an anionic surfactant and a nonionic surfactant; wherein the weight ratio of the anionic surfactant to the nonionic surfactant ranges from about 20:1 to about 1:20; and

[0230] (c) optionally at least one agrochemically acceptable excipient.

[0231] In one embodiment, the fungicide composition further comprises an antifreeze agent.

[0232] In a preferred embodiment, the antifreeze agent is monopropylene glycol.

[0233] In a preferred embodiment, the fungicide composition comprises monopropylene glycol in a concentration range of about 70 g / L to about 90 g / L.

[0234] In one embodiment, the fungicide composition further comprises an antifoaming agent.

[0235] In a preferred embodiment, the defoaming agent is a polysiloxane emulsion.

[0236] In a preferred embodiment, the fungicide composition comprises a silicone emulsion in a concentration range of about 5 g / L to about 15 g / L.

[0237] In one embodiment, the fungicide composition further comprises a thickener.

[0238] In a preferred embodiment, the thickener is xanthan gum.

[0239] In a preferred embodiment, the fungicide composition comprises xanthan gum in a concentration ranging from about 1 g / L to about 5 g / L.

[0240] In one embodiment, the fungicide composition further comprises a preservative.

[0241] In a preferred embodiment, the preservative is 1,2-benzisothiazolin-3-one.

[0242] In a preferred embodiment, the fungicide composition comprises 1,2-benzisothiazolin-3-one in a concentration range of about 0.5 g / L to about 3 g / L.

[0243] In one embodiment, the fungicide composition further comprises a solvent.

[0244] In a preferred embodiment, the solvent is water.

[0245] In one embodiment, the present disclosure provides a fungicide composition, which consists of the following components:

[0246] (a) Benzamide fungicides;

[0247] (b) a combination of surfactants comprising an anionic surfactant and a nonionic surfactant; wherein the weight ratio of the anionic surfactant to the nonionic surfactant ranges from about 20:1 to about 1:20; and

[0248] (c) optionally at least one agrochemically acceptable excipient.

[0249] In one embodiment, the present disclosure provides a fungicide composition consisting of the following components:

[0250] (a) Benzamide fungicides;

[0251] (b) a combination of surfactants comprising an anionic surfactant and a nonionic surfactant; wherein the weight ratio of the anionic surfactant to the nonionic surfactant ranges from about 20:1 to about 1:20; and

[0252] (c) at least one agrochemically acceptable excipient.

[0253] According to one embodiment, the present disclosure provides a fungicide composition, which consists of the following components:

[0254] (a) Benzamide fungicides;

[0255] (b) a combination of surfactants, the combination of surfactants comprising an anionic surfactant and a nonionic surfactant; wherein the weight ratio of the anionic surfactant to the nonionic surfactant ranges from about 20:1 to about 1:20;

[0256] (c) antifreeze;

[0257] (d) defoaming agents;

[0258] (e) thickeners;

[0259] (f) preservatives; and

[0260] (g) Solvent.

[0261] In a preferred embodiment, the present disclosure provides a fungicide composition, which consists of the following components:

[0262] (a) Zoxanil;

[0263] (b) a combination of sodium lignin sulfonate and ethoxylated isotridecanol; wherein the weight ratio of sodium lignin sulfonate to ethoxylated isotridecanol ranges from about 20:1 to about 1:20; and

[0264] (c) Water.

[0265] In one embodiment, the suspension concentrate fungicide composition may be in aqueous form.

[0266] In one embodiment, the aqueous suspension concentrate may further comprise a thickener and / or a biocidal compound.

[0267] In one embodiment, the suitable thickener is hydroxyethylcellulose, a cellulose-derived gelling agent and thickener. Particularly preferred is hydroxyethylcellulose surface-treated with glyoxal.

[0268] Suitable preservatives are typical biocidal compounds, for example 1,2-benzisothiazolin-3-one and mixtures of 1,2-benzisothiazol-3(2H)-one and 2-methyl-2H-isothiazol-3-one, biocides.

[0269] In a preferred embodiment of the present disclosure, the suspension concentrate further comprises a thickener and a biocidal compound in a concentration of up to about 1% w / w based on the total weight of the composition.

[0270] In a preferred embodiment, the present disclosure provides a suspension concentrate composition comprising:

[0271] (a) zoxadiazole; and

[0272] (b) a surfactant combination comprising sodium lignin sulfonate and ethoxylated isotridecanol;

[0273] Wherein the composition further comprises:

[0274] (c) Monopropylene glycol as antifreeze;

[0275] (d) polysiloxane emulsions as defoaming agents;

[0276] (e) xanthan gum as a thickening agent; and

[0277] (f) 1,2-Benzisothiazolin-3-one as a preservative.

[0278] In a preferred embodiment, the present disclosure provides a suspension concentrate (SC) fungicide composition, the suspension concentrate (SC) fungicide composition comprising:

[0279] (c) zoxadiazole;

[0280] (d) a surfactant combination comprising sodium lignin sulfonate and ethoxylated isotridecanol; and

[0281] (e) at least one agrochemically acceptable excipient;

[0282] The weight ratio of sodium lignin sulfonate to ethoxylated isotridecanol is in the range of about 10:1 to about 1:10.

[0283] In one embodiment, the present disclosure provides a suspension concentrate fungicide composition comprising:

[0284] (a) from about 10% to about 40% w / w of zoxadiazole;

[0285] (b) from about 1% to about 20% w / w of a combination of surfactants comprising anionic surfactants and nonionic surfactants; and

[0286] (c) from about 1% to about 30% w / w of an agrochemically acceptable excipient.

[0287] In one embodiment, the present disclosure provides a suspension concentrate fungicide composition comprising:

[0288] (a) benzamide fungicides; and

[0289] (b) a combination of surfactants comprising anionic surfactants and nonionic surfactants;

[0290] The fungicide composition is in the form of a tank mix or a preformulated (premixed) / premixed preparation.

[0291] According to one embodiment, the present disclosure provides a fungicide composition in the form of a preformulated (premixed) formulation.

[0292] In one embodiment, the present disclosure provides a premix suspension concentrate fungicide composition comprising:

[0293] (a) benzamide fungicides; and

[0294] (b) A combination of surfactants, the surfactant comprising an anionic surfactant and a nonionic surfactant.

[0295] Thus, in one embodiment, the fungicide compositions disclosed herein may be applied together as a premix formulation.

[0296] In another embodiment, the fungicide composition can be applied to the soil before the seedlings emerge (pre-emergence) to prevent fungal growth. Alternatively, the fungicide composition can be applied after the seedlings emerge (post-emergence) to prevent the growth of fungal plant pathogens.

[0297] In another embodiment, the fungicide composition can be applied as a foliar spray at different times during crop development, with multiple early applications (pre-emergence) or late applications (post-emergence) as needed.

[0298] In one embodiment, the present disclosure provides a method for preparing the present fungicide composition, particularly a liquid fungicide composition, more particularly a suspension concentrate fungicide composition.

[0299] According to one embodiment, the method for preparing a fungicide composition comprises:

[0300] (a) adding a combination of a benzamide fungicide and a surfactant to form a mixture;

[0301] (b) stirring and grinding the mixture; and

[0302] (c) adding at least one agrochemically acceptable excipient to the mixture of step (b) in water and homogenizing the mixture to obtain a fungicide composition.

[0303] In another embodiment, the method for preparing the fungicide composition comprises:

[0304] (a) adding bezobactam, sodium lignin sulfonate and ethoxylated isotridecanol into a feeding container to form a mixture;

[0305] (b) subjecting the mixture to high shear mixing and grinding; and

[0306] (c) adding a suitable agrochemically acceptable excipient to the mixture of step (b) in water and stirring the mixture to homogenize to obtain the fungicide composition.

[0307] In another embodiment, the present disclosure provides a method for preparing a suspension concentrate fungicide composition comprising:

[0308] (a) adding bezobactam, sodium lignin sulfonate and ethoxylated isotridecanol into a feeding container to form a mixture;

[0309] (b) The mixture is subjected to high shear stirring and grinding to obtain a particle size D 50 Less than about 5 microns; and

[0310] (c) adding an agrochemically acceptable excipient to the mixture of step (b) in water and stirring the mixture to homogenize to obtain the fungicide composition.

[0311] According to one embodiment, the present disclosure provides the use of a fungicide composition for controlling the growth of a fungal plant pathogen.

[0312] According to one embodiment, the present disclosure provides use of a fungicide composition comprising a benzamide fungicide and a combination of a surfactant comprising an anionic surfactant and a nonionic surfactant for controlling the growth of fungal plant pathogens.

[0313] The weight ratio of the anionic surfactant to the nonionic surfactant is in the range of about 20:1 to about 1:20.

[0314] In one embodiment, the present disclosure provides use of a fungicide composition comprising a combination of zoxamidin and a surfactant comprising an anionic surfactant and a nonionic surfactant for controlling plant pathogenic fungi and oomycetes.

[0315] In one embodiment, the present disclosure provides the use of a fungicide composition comprising a combination of zoxamidin and a surfactant comprising a sulfonic acid surfactant and an ethoxylated alcohol for controlling plant pathogenic fungi and oomycetes.

[0316] In one embodiment, the present disclosure provides for the use of a suspension concentrate fungicide composition comprising a combination of zoxamidin and a surfactant comprising a sulfonic acid surfactant and an ethoxylated alcohol for controlling plant pathogenic fungi and oomycetes.

[0317] In another aspect, the present disclosure provides the use of a suspension concentrate fungicide composition comprising a combination of zoxamidopropane and a surfactant comprising a sulfonic acid surfactant and an ethoxylated alcohol for increasing crop yield.

[0318] Thus, the fungicide composition of the present disclosure was found to be highly active against a variety of phytopathogenic fungi in crops.

[0319] In one embodiment, the crop can be selected from, but not limited to: cereals (such as wheat, oats, barley, spelt, triticale, rye, corn, millet, rice); crops (such as sugar cane, soybeans, sunflowers, rapeseed, rapeseed, tobacco, sugar beets, fodder beets); tuber crops such as potatoes and sweet potatoes; crops such as asparagus and hops; fruit trees (such as apples and pears), stone fruits (such as peaches, nectarines, cherries, plums, apricots), citrus fruits (such as oranges, grapefruits, limes, lemons, kumquats, tangerines, tangerines); nuts, such as pistachios, almonds, walnuts, pecans; tropical fruits, such as mangoes, papayas, pineapples, dates, bananas, etc., grapes; vegetables (such as lettuce, wild lettuce, lettuce, fennel, ball and loose leaf lettuce, beets, spinach, chrysanthemums, etc.); These include lettuce, cauliflower, broccoli, Chinese cabbage, kale (winter or curly kale), Brussels sprouts, Brussels sprouts, red cabbage, white cabbage and savoy cabbage); fruiting vegetables (e.g. eggplant, cucumber, red pepper, zucchini, tomato, courgette, sweet corn); root vegetables (e.g. celery, turnip, carrot, kohlrabi, radish, horseradish, beetroot, salsify, celery); leguminous vegetables (e.g. peas, beans, etc.); bulb vegetables (e.g. leeks, onions, etc.); oil crops (e.g. mustard, olives, sunflower, coconut, castor oil plant, cocoa beans, peanuts); fiber crops (e.g. cotton, jute, flax); crops such as tea, coffee, rubber; ornamentals, including shrubs and flowering plants; vines, grasslands and forages.

[0320] According to another embodiment, the fungicide composition may be applied to the plant or its locus or plant propagation material before or after the plant is infected by the fungal pathogen.

[0321] In another embodiment, the fungicide composition can be used for foliar application, ground application, plant application, locus application, or plant propagation material application, or a combination thereof.

[0322] According to one embodiment, the present disclosure provides a method for controlling the growth of a fungal plant pathogen, the method for controlling the growth of a fungal plant pathogen comprising:

[0323] An effective amount of a fungicide composition comprising a benzamide fungicide and a combination of a surfactant comprising an anionic surfactant and a nonionic surfactant is applied to a plant or its locus or its plant propagation material; wherein the weight ratio of the anionic surfactant to the nonionic surfactant ranges from about 20:1 to about 1:20.

[0324] In one embodiment, the present disclosure provides a method for controlling plant pathogenic fungi, the method for controlling plant pathogenic fungi comprising applying a fungicide composition to a site where fungal control is required, the fungicide composition comprising a combination of zoxamide and a surfactant, the surfactant comprising an anionic surfactant and a nonionic surfactant, wherein the weight ratio of the anionic surfactant to the nonionic surfactant ranges from about 20:1 to about 1:20.

[0325] In one embodiment, the present disclosure provides a method of controlling plant pathogenic fungi, the method of controlling plant pathogenic fungi comprising applying a suspension concentrate fungicide composition to a locus where fungal control is desired, the suspension concentrate fungicide composition comprising a combination of zoxamide and a surfactant, the surfactant comprising sodium lignin sulfonate and ethoxylated isotridecanol, wherein the weight ratio of sodium lignin sulfonate to ethoxylated isotridecanol ranges from about 20:1 to about 1:20.

[0326] In a preferred embodiment, the present disclosure provides a method for controlling plant pathogenic fungi, the method for controlling plant pathogenic fungi comprising applying a suspension concentrate fungicide composition to a locus where fungal control is desired, the suspension concentrate fungicide composition comprising a combination of zoxamide and a surfactant, the surfactant comprising sodium lignin sulfonate and ethoxylated isotridecanol, wherein the weight ratio of sodium lignin sulfonate to ethoxylated isotridecanol ranges from about 15:1 to about 1:15.

[0327] In one embodiment, the fungicide composition can be used to control fungal diseases, such as pea diseases caused by one or more of the following species: Alternaria alternata, Aphanomyces euteiches f. sp. pisi, Ascochyta pinodella, Ascochytapinodes, Ascochyta pisi, Botryotinia fuckeliana, Botrytis cinerea, Cercospora pisa-sativae, Chalaraelegans, Cladosporium cladosporioides f. sp. pisicoia, Cladosporium pisicoia, Colletotrichum gloeosporioides, Colletotrichum pisi), Erysiphe pisi, Fusarium oxysporum, Fusarium oxysporum.sp.pisi, Fusarium solani, Fusicladium pisicoia, Glomerella cingulata, Mycosphaerella pinodes, Oidium sp., Peronosporaviciae, Phoma pinodella, Pythium spp., Rhizoctonia solani, Sclerotinia sclerotiorum, Septoriapisi, Thanatephorus cucumeris, Thielaviopsis hasicola, and Uromyces rust fabae, soybean diseases: Cercospora kikuchii, Elsinoe glycines, Diaporthe phaseolorum var.sojae), Septoria glycines, Cercospora sojina, Phakopsora pachyrhizi, Phytophthora sojae, and Rhizoctonia solani.

[0328] The methods of the present disclosure can be used to control a wide range of plant diseases, such as:

[0329] Rice diseases: Rice blast (Magnaporthe grisea), helminth leaf spot (Cochliobolus miyabeanus), sheath blight (Rhizoctonia solani), and bakanae (Gibberella fujikuroi).

[0330] Wheat diseases: powdery mildew (Erysiphe graminis), Fusarium ear blight (Fusarium graminearum, F. avenacerum, F. culmorum, Microdochium nivale), rust (Puccinia striiformis, P. graminis, P. recondita), snow mold (Micronectriella nivale), snow rot (Typhula sp.), loose smut (Ustilago tritici), wheat grain disease (Tilletia caries), eye spot disease (Pseudocercosporella herpotrichoides), leaf spot (Mycosphaerella graminicola), glumemma (Stagonospora nodorum), black spot and yellow spot (Pyrenophora tritici-repentis).

[0331] Barley diseases: powdery mildew (Erysiphe graminis), fusarium ear blight (Fusarium graminearum), avenacerum (F. avenacerum), yellow fusarium (F. culmorum), snow mold Microdochium (Microdochium nivale), rust (Puccinia striiformis, P. graminis, leaf rust (P. hordei), loose smut (Ustilago nuda), scald (Rhynchosporium secalis), web spot (Pyrenophora teres), spot (Cochliobolus sativus), sheath blight (Pyrenophora graminea), and rhizoctonia rot (Rhizoctonia solani solani))

[0332] Corn diseases: smut (Ustilago maydis), brown spot (Cochliobolus heterostrophus), copper spot (Gloeocercospora sorghi), southern rust (Puccinia polysora), gray spot (Cercosporazeae-maydis), white spot (Phaeosphaeria mydis and / or Pantoea ananatis), and rhizoctonia rot (Rhizoctonia solani).

[0333] Citrus diseases: melanosis (Diaporthe citri), scab (Elsinoefawcetti), penicillium rot (Penicillium digitatum, P. italicum), and brown rot (Phytophthora parasitica, Phytophthora citrophthora).

[0334] Apple diseases: blossom end rot (Monilinia mali), canker (Valsa ceratosperma), powdery mildew (Podosphaera leucotricha), alternaria leaf spot (Alternaria altemata apple pathotype), scab (Venturia inaequalis), powdery mildew, bitter rot (Colletotrichum acutatum), crown rot (Phytophtora cactorum), spot (Diplocarpon malí) and ring rot (Botryosphaeria berengeriana).

[0335] Pear diseases: scab (Venturia nashicola, V. pirina), powdery mildew, black spot (Alternaria alternata), rust (Gymnosporangium haraeanum), and phytophthora fruit rot (Phytophtora cactorum).

[0336] Peach diseases: brown rot (Monilinia fructicola), powdery mildew, scab (Cladosporium carpophilum), and phomopsis rot (Phomopsis sp.).

[0337] Grape diseases: Anthracnose (Elsinoe ampelina), late rot (Glomerella cingulata), powdery mildew (Uncinula necator), rust (Phakopsora ampelopsidis), black rot (Guignardia bidwellii), gray mold and downy mildew (Plasmopara vitícola).

[0338] Diseases of Japanese persimmon: Anthracnose (Gloeosporium kaki) and leaf spot (Cercospora kaki, Mycosphaerella nawae).

[0339] Cucurbit diseases: Anthracnose (Colletotrichum lagenarium), powdery mildew (Sphaerotheca fuliginea), vine blight (Mycosphaerella melonis), Fusarium wilt (Fusarium oxysporum), downy mildew (Pseudoperonospora cubensis), blight (Phytophthora sp.), and damping-off (Pythium sp.).

[0340] Tomato diseases: early blight (Alternaria solani), leaf mold (Cladosporium fulvum), and late blight (Phytophthora infestans).

[0341] Eggplant diseases: Brown spot (Phomopsis vexans) and powdery mildew (Erysiphe cichoracearum). Cruciferous vegetable diseases: Alternaria leaf spot (Alternaria japonica), white spot (Cercosporella brassicae), clubroot (Plasmodiophora brassicae) and downy mildew (Peronospora parasitica).

[0342] Onion diseases: Rust (Puccinia allii) and downy mildew (Peronospora destructor)

[0343] Bean diseases: purple seed spot (Cercospora kikuchii), black bean disease (Elsinoe glycines), pod and stem blight (Diaporthe phaseolorum var. sojae), soybean black spot (Septoria glycines), gray spot (Cercospora sojina), rust (Phakopsora pachyrhizi), yellow rust, brown stem rot (Phytophthora sojae), and rhizoctonia rot (Rhizoctonia solani).

[0344] Kidney bean diseases: Anthracnose (Colletotrichum lindemthianum). Peanut diseases: Leaf spot (Cercospora personata), brown spot (Cercosporaarachidicola), and white spot (Sclerotium rolfsii).

[0345] Pea diseases: powdery mildew (Erysiphe pisi) and root rot (Fusarium solanif. sp. pisi).

[0346] Potato diseases: early blight (Alternaria solani), late blight (Phytophthora infestans), pink rot (Phytophthora erythroseptica), and powdery scab (Spongospora subterranean f.sp. subterranea).

[0347] Strawberry diseases: powdery mildew (Sphaerotheca humuli) and anthracnose (Glomerella cingulata).

[0348] Tea tree diseases: blister blight (Exobasidium reticulatum), white scab (Elsinoe leucospila), gray blight (Pestalotiopsis sp.), and anthracnose (Colletotrichum theae-sinensis).

[0349] Tobacco diseases: Brown spot (Alternaria longipes), powdery mildew (Erysiphe cichoracearum), anthracnose (Colletotrichum tabacum), downy mildew (Peronospora tabacina), and blackleg (Phytophthora nicotianae).

[0350] Rapeseed diseases: Sclerotinia sclerotiorum and Rhizoctonia rot (Rhizoctonia solani). Cotton diseases: Rhizoctonia rot (Rhizoctonia solani).

[0351] Sugar beet diseases: Cercospora leaf spot (Cercospora beticola), leaf blight (Thanatephorus cucumeris), root rot (Thanatephorus cucumeris), and Aphanomyces root rot (Aphanomyces cochlioides).

[0352] Rose diseases: black spot (Diplocarpon rosae), powdery mildew (Sphaerotheca pannosa) and downy mildew (Peronospora sparsa), chrysanthemum and Asteraceae diseases: downy mildew (Bremiamilkucae), leaf blight (Septoria chrysanthemi-indici) and white rust (Puccinia horiana).

[0353] Diseases: Diseases caused by Pythium fungi (Pythium aphanidiormatum, Pythium debarianum, Pythium graminicola, Pythium irregulare, Pythium ultimum), gray mold (Botrytis cinerea) and sclerotinia (Sclerotinia sclerotiorum).

[0354] Japanese radish diseases: Brassica Alternaria black spot (Alternaria brassicicola).

[0355] Turfgrass diseases: round spot (Sclerotinia homeocarpa), brown spot, and large spot (Rhizoctonia solani).

[0356] Banana diseases: black banana leaf spot (Mycosphaerellafijiensis), yellow banana leaf spot (Mycosphaerella musicola).

[0357] Sunflower diseases: downy mildew (Plasmopara halstedii.

[0358] Seed diseases or various early plant growth diseases caused by Aspergillus, Penicillium, Fusarium, Gibberellic acid, Triacanthus, Thielavia, Rhizopus, Mucor, Corticostria, Phoma, Rhizoctonia and Diploidycetes.

[0359] A viral disease of many plants mediated by Polymixa spp. or Olpidium spp.

[0360] The present disclosure also provides a method for protecting plant propagation materials, preferably seeds, and roots and shoots of seedlings from plant pathogenic fungi, which method comprises contacting the plant propagation materials (such as seeds) with the composition of the present disclosure before sowing and / or after germination.

[0361] According to one embodiment, the present disclosure provides a method of controlling the growth of fungal plant pathogens, wherein the fungicide composition is applied in the range of about 10 g ai / ha to about 5000 g ai / ha.

[0362] In one embodiment, the present disclosure provides a method of controlling the growth of a fungal plant pathogen, wherein the fungicide composition is applied in the range of about 10 g ai / ha to about 3000 g ai / ha.

[0363] In one embodiment, the present disclosure provides a method of controlling the growth of fungal plant pathogens, wherein the fungicide composition is applied in the range of about 10 g ai / ha to about 1500 g ai / ha.

[0364] In one embodiment, the present disclosure provides a method of controlling the growth of fungal plant pathogens, wherein the fungicide composition is applied in the range of about 10 g ai / ha to about 500 g ai / ha.

[0365] In one embodiment, the present disclosure provides a method of controlling the growth of a fungal plant pathogen, wherein the fungicide composition is applied in the range of about 50 g ai / ha to about 450 g ai / ha.

[0366] According to one embodiment, the various components of the suspension concentrate fungicide composition can be used alone or have been partially or completely mixed with each other to prepare the suspension concentrate fungicide composition. The components can also be packaged separately and used as components in a partial kit.

[0367] In one embodiment, the kit may include one or more components for preparing a suspension concentrate fungicide composition. For example, the kit may include a combination of active ingredients and / or surfactants. One or more components may have been combined or pre-formulated.

[0368] According to an embodiment of the present disclosure, a kit comprising a stable agricultural chemical composition is provided. The kit comprises a plurality of components, which include at least one ingredient of the stable fungicide composition of the present disclosure.

[0369] In one embodiment of the present disclosure, the kit includes at least one or all components required for preparing a stable fungicide composition. For example, the kit may include zoxamide, anionic surfactants and nonionic surfactants.

[0370] One or more components may have been combined together or preformulated. In embodiments where more than two components are provided in the kit, these components may have been combined and packaged as is in a single container such as a vial, bottle, can, pouch, bag and / or jar. In other embodiments, two or more components of the kit may be packaged separately, i.e. they are not preformulated. Thus, the kit may include one or more separate containers, such as vials, cans, bottles, pouches, bags and / or jars, each containing a separate component of the stable fungicide composition.

[0371] In both forms, the components of the kit may be applied separately from the other components or together as components of a combination or composition according to the disclosure to prepare a stable fungicide composition according to the disclosure.

[0372] The present disclosure also provides a kit comprising a fungicide composition for controlling the growth of fungal plant pathogens and instructions for use. The instructions generally comprise instructions for applying the fungicide composition to a plant, or a locus thereof, or to its plant propagation material.

[0373] According to one embodiment, the kit comprises:

[0374] (a) benzamide fungicides; and

[0375] (b) a combination of surfactants comprising anionic surfactants and nonionic surfactants;

[0376] and optionally further comprises:

[0377] (c) Instructions for use.

[0378] In another embodiment, the kit comprises:

[0379] (a) zoxadiazole; and

[0380] (b) a surfactant combination comprising a sulfonic acid surfactant and an ethoxylated alcohol;

[0381] and optionally further comprising:

[0382] (c) Instructions for use.

[0383] In a preferred embodiment, the kit comprises:

[0384] (a) zoxadiazole; and

[0385] (b) a surfactant combination comprising sodium lignin sulfonate and ethoxylated isotridecanol;

[0386] and optionally further comprising:

[0387] (c) Instructions for use.

[0388] The above composition has fungicidal effect and is stable. Studies have found that the surfactant mixture of the suspension concentrate fungicide composition of the present disclosure has excellent stability over time and at different temperatures, even when the suspension concentrate fungicide composition is subjected to shear forces, such as during mixing. In addition, the stable fungicide composition obtained by the disclosed method has excellent suspensibility, better dispersibility, little or no sedimentation, and little particle degradation.

[0389] All features described herein can be combined arbitrarily with any of the above aspects. In order to more easily understand the present disclosure, reference will now be made to the following description by way of example. However, the scope of the present disclosure is not subject to any limitation of the examples. Those skilled in the art will appreciate that the present disclosure includes the aforementioned examples and can be further modified and changed within the technical scope of the present disclosure.

[0390] It should be understood that unless otherwise stated herein, or unless otherwise stated in the referenced test methods and procedures, all tests and physical properties listed are measured at atmospheric pressure and room temperature (ie, 25°C).

[0391] It should be understood that this description and examples are illustrative rather than limiting of the present disclosure, and those skilled in the art may select other embodiments according to the nature and scope of the present disclosure. Other embodiments may also be implemented within the scope of the present disclosure. The following examples illustrate the present invention, but are in no way intended to limit the scope of the claims.

[0392] Example

[0393] This disclosure will be described with reference to the following examples:

[0394] Example 1: Composition of SC suspension of oxadiazine

[0395] Element Quantity (w / w) % Benzamide; 22.15 Ethoxylated isotridecanol 1.12 Monopropylene glycol 7.16 Sodium lignin sulfonate 8.95 Dimethicone Oil 0.90 water QS total 100

[0396] method:

[0397] The method for preparing the suspension concentrate fungicide composition includes the corresponding amounts of the ingredients in the above table. Water is added to a container under stirring, followed by the addition of polydimethylsiloxane oil. Ethoxylated isotridecyl alcohol is heated to a temperature of about 25°C to about 30°C and then homogenized before use. Monopropylene glycol and sodium lignin sulfonate are charged to a container, followed by the addition of zoxamide. During the addition of the active ingredients, the mixture is homogenized by stirring and passed through a colloid mill. The stirrer in the charging tank is set to a low speed and stirring is continued during the grinding process to prevent settling. The slurry is ground using a horizontal bead mill and the processing conditions are adjusted so that the temperature of the ground slurry does not exceed about 40°C. The complete ground base is transferred to a storage tank. The gel is added to the storage tank and stirred continuously until a completely uniform state is achieved.

[0398] Example 2: Physicochemical stability data

[0399] The stability of the zoxamide SC composition prepared according to Example 1 was evaluated for the stability of physical parameters under accelerated heat stability (AHS) conditions (2 weeks at 54°C) and 3 months at 40°C.

[0400] Table 2: Physical properties of the composition of Example 1

[0401]

[0402] Sediment

[0403] Y = normal sediment

[0404] N = No precipitate or undetectable precipitate

[0405] Water hardness

[0406] Water D: 342ppm

[0407] Water A: 20ppm

[0408] Dispersion stability

[0409] H = uniform appearance

[0410] H = uniform S = precipitate (ml)

[0411] F = Flocculation

[0412] The stability of the composition was evaluated at 54°C for 2 weeks and at 40°C for 3 months and compared to initial observations of the composition.

[0413] The study found that the active content remained almost constant without any significant deterioration or loss. The composition also passed the wet sieve test as no crystal residue was observed on the wet sieve. The particle size of the composition was analyzed and found to be almost constant, indicating that the particle size growth or crystal formation was negligible (Table 2). The pH value was also maintained at a high level during the tested time period. The composition of Example 1 showed improved suspension, improved uniformity and no precipitation. Therefore, it is concluded that the composition of Example 1 remains stable in the environment and AHS, which ensures the overall stability of the composition.

[0414] Example 3: Surfactant screening and comparative study

[0415] Different anionic and nonionic surfactants were tested individually and in various combinations, and then a stable combination of surfactants that helped to form a stable suspension concentrate composition was determined. After determining the optimal weight of the active ingredient and surfactant combination, various anionic and nonionic surfactants were tested to evaluate their impact on the final composition.

[0416] In order to compare the physical stability, keeping the active ingredients of the present composition unchanged, various surfactants were combined in an optimal ratio to develop these compositions, which were named as Comparative Examples 'A', 'B' and 'C', respectively. The stability test was conducted at 54°C for 2 weeks.

[0417] The present disclosure provides a rationale for selecting surfactants for use in fungicide compositions.

[0418] Table 3: Surfactant screening

[0419]

[0420]

[0421] NT: Not Tested The present composition as described above has a high pH value and a low surface tension, which facilitates application in crops.

[0422] Example 4: Stability Study

[0423] The stability of the zoxamide SC composition prepared according to Example 1 was evaluated for the physical parameters at 0°C and 25°C for 6 and 12 months.

[0424] Table 4: Physical properties of the composition of Example 1

[0425]

[0426] Sediment:

[0427] Y = normal sediment

[0428] N = No precipitate or undetectable precipitate

[0429] The stability of the composition was evaluated at 6 and 12 months at 0°C and 25°C and compared with the initial observations of the composition. The particle size of the composition was analyzed and found to be almost constant, indicating that there was little or negligible particle size growth or crystal formation. The pH value was also maintained at a high level during the tested time period. No precipitation occurred in the composition of Example 1. Therefore, it was concluded that the composition of Example 1 remained stable from 6 to 12 months, which ensured the overall stability of the composition.

[0430] Example 5: Composition of zoxadiazole suspension concentrate (SC)

[0431]

[0432]

[0433] method:

[0434] The preparation method of the composition of Example 5 is the same as disclosed in Example 1.

[0435] Thus, the inventors of the present disclosure have discovered that the suspension concentrate compositions developed according to the present disclosure use selected anionic and nonionic surfactants to form stable compositions. The performance of the selected surfactants improves over time with little or no precipitation and less reduction in particle size. The suspension concentrate compositions prepared according to the present disclosure also pass the wet sieve test, indicating that the product is stable.

Claims

1. A fungicide composition, comprising: (a) benzamide fungicides; and (b) a combination of surfactants, the surfactant comprising an anionic surfactant and a nonionic surfactant; The weight ratio of the anionic surfactant to the nonionic surfactant is in the range of about 20:1 to about 1:

20.

2. The composition according to claim 1, wherein the benzamide fungicide is selected from the group consisting of benzohydroxamic acid, fluopyram, fluopyram, fluopyram, thiocyanate, salicylam, cyanamide, zoxamide, their salts, isomers or combinations thereof.

3. The composition according to claim 2, wherein the benzamide fungicide is zoxamidopropynil.

4. The composition according to claim 1, wherein the anionic surfactant is a sulfonic acid surfactant selected from the group consisting of sodium alkylnaphthalene sulfonate, sodium naphthalene sulfonate, calcium lignin sulfonate, sodium lignin sulfonate, sodium polynaphthalene sulfonate and ammonium lignin sulfonate, or a combination thereof.

5. The composition according to claim 4, wherein the anionic surfactant is sodium lignin sulfonate.

6. The composition of claim 1, wherein the nonionic surfactant is an ethoxylated alcohol selected from the group consisting of alkylamine ethoxylates, acrylate graft copolymer ethoxylates, block polymers, carboxylated alcohol or alkylphenol ethoxylates, alcohol ethoxylates, ethoxylated alkylphenols, glycol esters, polyethylene glycols, silicone-based surfactants, tristyrylphenol ethoxylates, ethoxylated isotridecanols, or combinations thereof.

7. The composition of claim 6, wherein the nonionic surfactant is ethoxylated isotridecanol.

8. The composition of claim 1, wherein the composition comprises from about 10% w / w to about 50% w / w of the benzamide fungicide based on the total weight of the composition.

9. The composition of claim 1, wherein the composition comprises a combination of surfactants in an amount from about 1% w / w to about 40% w / w based on the total weight of the composition.

10. The composition of claim 1, wherein the composition comprises from about 1% w / w to about 30% w / w of anionic surfactant based on the total weight of the composition, and from about 0.5% w / w to about 20% w / w of nonionic surfactant based on the total weight of the composition.

11. A suspension concentrate composition comprising: (a) Zoxanil; (b) a combination of surfactants comprising sodium lignin sulfonate and ethoxylated isotridecanol; and (c) at least one agrochemically acceptable excipient; The weight ratio of sodium lignin sulfonate to ethoxylated isotridecanol is in the range of about 10:1 to about 1:

10.

12. The composition of claim 11, wherein the agrochemically acceptable excipient is selected from the group consisting of a wetting agent, a dispersant, a binder, an antifreeze agent, a surfactant, a preservative, a mineral, a colorant, a pH adjuster, an antifoaming agent, a solvent, or a combination thereof.

13. Use of the fungicide composition according to claim 1 for controlling the growth of fungal plant pathogens.

14. A method for preparing the fungicide composition according to claim 1, comprising: (a) adding a combination of a benzamide fungicide and a surfactant to form a mixture; (b) stirring and grinding the mixture; as well as (c) adding at least one agrochemically acceptable excipient to said mixture of step (b) in water and homogenizing said mixture to obtain said fungicide composition.

15. A method for controlling the growth of a fungal plant pathogen, the method comprising: applying to the plant or the locus thereof or its plant propagation material an effective amount of a fungicide composition comprising a combination of a benzamide fungicide and a surfactant comprising an anionic surfactant and a nonionic surfactant; The weight ratio of the anionic surfactant to the nonionic surfactant is in the range of about 20:1 to about 1:20.

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