Formula food for children as well as preparation method and application of formula food

Abstract

The invention provides a formula food for children and a preparation method and application thereof, the formula food for children comprises zinc, lactoferrin and yeast beta-glucan, and the raw materials of the formula food for children comprise bovine colostrum, lactoferrin and yeast beta-glucan. On the basis of the dry matter mass of the zinc, the lactoferrin, the yeast beta-glucan and the bovine colostrum in the raw materials of the formula food for children, the mass ratio of the zinc to the lactoferrin to the yeast beta-glucan to the bovine colostrum in the raw materials of the formula food for children is (1.5-12): (16-800): (14-75): (95-480); according to the amount of dry matter of the infant formula food, the total protein content is 8 g to 30 g / 100 g, the fat content is 10 g to 35 g / 100 g, and the carbohydrate content is 35 g to 70 g / 100 g.

Description

Technical Field

[0001] The invention belongs to the technical field of infant and children's food, and specifically relates to a pediatric formula food and a preparation method and application thereof. Background Art

[0002] The early stage of life is the fastest period of growth and development of the body. The childhood stage is the golden period of growth and development throughout the entire life stage. It is very important to ensure the stable growth and development of children. Balanced nutrition has the most important impact on growth and development. The younger the age, the greater the impact of nutrition. Nutrition and health status at this stage have an important impact on weight, height growth, bone development, immune system development and brain maturation, intestinal flora, etc. Malnutrition in children can lead to varying degrees of growth retardation, affecting the growth of weight and height and the development of various organs, especially the brain and skeletal system, causing future physical development, motor skills and intellectual development to lag behind normal children.

[0003] As for bone growth, bone growth and development are rapid during childhood and adolescence, with bone construction as the main process, accelerated bone turnover, and bone formation as the dominant process, so bone mass grows steadily. The weight of human bones at birth is 70-95g. By the end of adolescence, the average total weight of bones reaches 2400g for females and 3300g for males. Bone growth includes linear growth and bone mass accumulation. Linear growth is the main growth in childhood, and the average growth rate is about 5-6cm per year. Bone mass accumulation is the main process during adolescence, especially puberty. About 40%-60% of adult bone mass is achieved during adolescence, and 90% of peak bone mass has been accumulated by the age of 18. Therefore, if we can make full use of the rapid bone mass accumulation period in childhood and adolescence to promote the body to reach a higher peak bone mass, it will have positive significance for the bone health of children and adolescents and the prevention of osteoporosis in middle-aged and elderly people.

[0004] There are many internal and external factors that affect the growth and development of bones in children and adolescents, such as genetics, endocrine, nutrition, exercise, disease and drugs. Nutrition plays an important role in bone growth and development and height growth. Therefore, it is necessary to adjust and optimize the nutrient ratio in a targeted manner when developing children's formula milk powder to achieve the best nutritional effect and promote children's growth.

[0005] Currently, in the field of infant and children's food, a lot of research has been done on the effects of nutrients such as protein, fat, calcium, vitamin D, etc. on height growth. However, there are fewer studies on the effects of the combined effects of lactoferrin, bovine colostrum, etc. on bone health and height. A solution is needed to find the proportion and method of adding these ingredients to achieve the best nutritional effect. Summary of the invention

[0006] In order to solve the above technical problems, the purpose of the present invention is to provide a pediatric formula food and its preparation method and application. The pediatric formula food comprises zinc, lactoferrin, yeast β-glucan and bovine colostrum in raw materials, and has the effect of promoting children's growth.

[0007] To achieve the above object, the present invention first provides a pediatric formula food, wherein the pediatric formula food comprises zinc, lactoferrin and yeast β-glucan, the raw material of the pediatric formula food comprises bovine colostrum, and the mass ratio of zinc, lactoferrin, yeast β-glucan to bovine colostrum in the raw material of the pediatric formula food is 1.5-12:16-800:14-75:95-480 based on the dry matter mass of the zinc, lactoferrin, yeast β-glucan and bovine colostrum in the raw material of the pediatric formula food;

[0008] Wherein, based on the dry weight of the pediatric formula food, the total protein content is 8g-30g / 100g, the fat content is 10g-35g / 100g, and the carbohydrate content is 35g-70g / 100g.

[0009] In the above-mentioned pediatric formula food, preferably, the pediatric formula food is infant formula food or children's formula milk powder, preferably children's formula milk powder.

[0010] In the above-mentioned pediatric formula food, preferably, based on the dry matter amount of the infant formula food, the total protein content is 8g-22g / 100g, the proportion of whey protein to total protein is 40%-75%, the fat content is 15g-33g / 100g, and the carbohydrate content is 50g-70g / 100g; preferably, based on the amount of dry matter of the infant formula food, the total protein content is 10g-18g / 100g, the proportion of whey protein to total protein is 40%-70%, the fat content is 18g-30g / 100g, and the carbohydrate content is 52g-60g / 100g;

[0011] Calculated based on the dry matter amount of the children's formula milk powder, the total protein content is 16.5g-30g / 100g, the fat content is 10-35g / 100g, and the carbohydrate content is 35-70g / 100g; preferably, calculated based on the dry matter amount of the children's formula milk powder, the total protein content is 17g-25g / 100g, the fat content is 10-25g / 100g, and the carbohydrate content is 45-60g / 100g.

[0012] According to some specific embodiments of the present invention, in the pediatric formula food of the present invention, the infant formula food is an infant formula food for infants aged 0-6 months, an older infant formula food for infants aged 6-12 months, or an infant formula food for infants aged 12-36 months, and the children's formula milk is a children's formula milk for children aged 3 years and above, wherein:

[0013] Infant formula food for infants aged 0-6 months has a total protein content of 8-15 g / 100 g, preferably 10-15 g / 100 g, a whey protein content of 60-75% of the total protein, a fat content of 23-30 g / 100 g, a linoleic acid content of 2700-6000 mg / 100 g, an α-linolenic acid content of 270-600 mg / 100 g, and a carbohydrate content of 50-60 g / 100 g.

[0014] The total protein content of the formula food for older infants aged 6-12 months is 8-20 g / 100 g, preferably 10-20 g / 100 g, the proportion of whey protein in the total protein is 40-75%, the fat content is 20-30 g / 100 g, the linoleic acid content is 2700-4500 mg / 100 g, the α-linolenic acid content is 270-450 mg / 100 g, and the carbohydrate content is 50-60 g / 100 g.

[0015] In the infant formula food for infants aged 12-36 months, the total protein content is 8-20g / 100g, preferably 10-20g / 100g, the fat content is 20-30g / 100g, the linoleic acid content is 2700-4500mg / 100g, the α-linolenic acid content is 270-450mg / 100g, and the carbohydrate content is 50-60g / 100g.

[0016] The total protein content of children's formula milk for children over 3 years old, converted to dry matter, is 16.5g-30g / 100g, the fat content is 10-35g / 100g, and the carbohydrate content is 35-70g / 100g.

[0017] The pediatric formula food is infant formula food or children's formula milk powder, preferably children's formula milk powder.

[0018] In the above-mentioned pediatric formula food, preferably, the mass ratio of the zinc, lactoferrin, yeast β-glucan to the bovine colostrum in the raw materials of the pediatric formula food is 1.6-11.9:20-800:14.7-70:98.1-476;

[0019] More preferably, the mass ratio of the zinc, lactoferrin, yeast β-glucan to the bovine colostrum in the raw materials of the pediatric formula food is 1.6-11.9:30-800:15-70:100-476.

[0020] According to some specific embodiments of the present invention, the mass ratio of the zinc, lactoferrin, yeast β-glucan to the bovine colostrum in the raw materials of the pediatric formula food is 1.6-11.9:50-800:15-49:110-476.

[0021] According to some specific embodiments of the present invention, in the pediatric formula food of the present invention, the mass ratio of lactoferrin, yeast β-glucan to bovine colostrum in the raw materials of the pediatric formula food is 5-20: 6-12: 40-80. The amount of zinc can be determined by referring to the aforementioned ratio range of zinc to lactoferrin.

[0022] According to some specific embodiments of the present invention, in the pediatric formula food of the present invention, the mass ratio of lactoferrin, yeast β-glucan to bovine colostrum in the raw materials of the pediatric formula food is 40-60:6-12:40-80. The amount of zinc can be determined by referring to the aforementioned ratio range of zinc to lactoferrin.

[0023] According to some specific embodiments of the present invention, in the pediatric formula food of the present invention, the mass ratio of lactoferrin, yeast β-glucan to bovine colostrum in the raw materials of the pediatric formula food is 80-120:6-12:40-80. The amount of zinc can be determined by referring to the aforementioned ratio range of zinc to lactoferrin.

[0024] According to a specific embodiment of the present invention, the pediatric formula food of the present invention contains 1.8-20 mg zinc / 100 g food dry matter.

[0025] According to some preferred specific embodiments of the present invention, the pediatric formula contains zinc, lactoferrin, yeast β-glucan and bovine colostrum in the raw materials of the pediatric formula at 2.0-19.8 mg / 100 g food dry matter, 20-1323 mg / 100 g food dry matter, 16.3-119 mg / 100 g food dry matter and 109-800 mg / 100 g food dry matter, respectively.

[0026] According to some preferred specific embodiments of the present invention, the pediatric formula contains zinc, lactoferrin, yeast β-glucan and bovine colostrum in the raw materials of the pediatric formula food at 2.0-19.8 mg / 100 g food dry matter, 30-1300 mg / 100 g food dry matter, 20-80 mg / 100 g food dry matter and 110-800 mg / 100 g food dry matter, respectively.

[0027] According to some preferred specific embodiments of the present invention, the pediatric formula food contains 2.0-19.8 mg / 100 g of zinc, 50-1300 mg / 100 g of lactoferrin, 16.3-50 mg / 100 g of yeast β-glucan and the bovine colostrum in the raw materials of the pediatric formula food are 160-800 mg / 100 g of dry matter.

[0028] According to a specific embodiment of the present invention, in the pediatric formula food of the present invention, the raw materials providing total protein, in addition to bovine colostrum, may also selectively include other protein raw materials, such as: one or more of raw milk (cow / sheep), whole milk powder (cow / sheep), skim milk powder (cow / sheep), whey protein powder (cow / sheep), desalted whey powder (cow / sheep), β-casein, etc. Specifically, based on 1000 parts by weight of the children's formula milk powder of the present invention, its raw materials include: 0-7000 parts of raw milk (cow / sheep), 0-260 parts of whole milk powder (cow / sheep), 0-120 parts of whey protein powder (cow / sheep), 0-500 parts of skim milk powder (cow / sheep), and / or 0-600 parts of desalted whey powder (cow / sheep).

[0029] According to a specific embodiment of the present invention, in the infant formula food of the present invention, the raw materials providing fat may include: raw milk (cow / sheep), whole milk powder (cow / sheep), cream (cow / sheep), corn oil, soybean oil, sunflower oil, 1,3-dioleic acid-2-palmitic acid triglyceride, coconut oil, rapeseed oil, linseed oil, etc. One or more. Specifically, based on 1000 parts by weight of infant formula food or children's modulated milk powder, its raw materials include one or more of the following raw materials in parts by weight: 0-7000 parts of raw milk (cow / sheep), 0-260 parts of whole milk powder (cow / sheep), 0-50 parts of corn oil, 0-65 parts of soybean oil, 0-100 parts of sunflower oil, 0-240 parts of 1,3-dioleic acid-2-palmitic acid triglyceride, 0-30 parts of coconut oil, 0-85 parts of rapeseed oil, and 0-20 parts of linseed oil.

[0030] According to a specific embodiment of the present invention, in the children's formula food of the present invention, in addition to the above-mentioned components, the conventional components of infant formula food or children's modulated milk powder may also be included, for example, nutrients, dietary fiber, phosphatidylserine, inositol, taurine, L-carnitine, docosahexaenoic acid, (3R, 3'R)-dihydroxy-β-carotene, eicosatetraenoic acid, lutein, one or more of animal bifidobacterium lactis subspecies, etc. are also included. Preferably, a composite nutrient package is included. In some preferred embodiments, the children's modulated milk powder is converted into 1000 weight portions of dry matter, and its raw materials include 1-20 parts of nutrients, and the nutrients include vitamins and minerals, or further selectively include dietary fiber (fructooligosaccharides, galacto-oligosaccharides, polyfructose, breast milk oligosaccharides, isomerized lactose liquid, etc.), inositol, taurine, L-carnitine, docosahexaenoic acid, eicosatetraenoic acid, lutein, one or more of animal bifidobacterium lactis subspecies. The compound nutrients mainly include: compound vitamins: vitamin A, vitamin D, vitamin E, vitamin K1, vitamin K2, vitamin B1, niacin, folic acid, pantothenic acid, vitamin C, choline, taurine; compound minerals: calcium, iron, zinc and their derivatives. The sources, contents and usage of the vitamins and minerals should comply with the national standards and relevant regulations for children's formula milk powder.

[0031] The present invention also provides a method for preparing the above-mentioned pediatric formula food. The infant formula food and children's formula milk powder of the present invention can be prepared according to the following method: using a wet method or a dry method or a dry-wet composite production process, β-casein, OPO structural lipids and vitamin B6 composition are mixed with other raw materials in the formula to prepare the infant formula food or children's formula milk powder. In some more specific embodiments, the preparation process of infant formula food or children's formula milk powder mainly includes: batching, homogenization, concentration and sterilization, spray drying, and dry mixing to obtain the finished product, which specifically includes the following steps: the raw milk is inspected, roughly filtered, stored after cooling, and pasteurized at 90-100°C for 10-60s and placed in a mixing tank, and the raw materials are fully mixed in proportion to obtain a mixed material; the mixed material is homogenized after filtering and removing impurities, and the homogenization temperature is 50-60°C and the pressure is 120-200 bar, to obtain a homogeneous material; the homogeneous material is concentrated, and the dry matter weight content of the concentrate is 40-60%; the concentrated material is sterilized at 90-100°C for 10-60s to obtain a sterilized material; the sterilized material is dried by a spray drying tower, with an inlet air temperature of 150-200°C, an exhaust air temperature of 80-120°C, a negative pressure of -10 to -2mmWG, a high-pressure pump pressure of 140-250bar, and then introduced into a fluidized bed for secondary drying to obtain a pediatric formula food.

[0032] According to a specific embodiment of the present invention, in the pediatric formula food of the present invention, the zinc, lactoferrin, yeast β-glucan and the bovine colostrum raw material in the raw materials of the pediatric formula food can all be commercially available.

[0033] According to a specific embodiment of the present invention, in the pediatric formula food of the present invention, the raw materials providing zinc include one or a combination of two or more of zinc sulfate, zinc gluconate, zinc glycinate, zinc oxide, zinc lactate, zinc citrate, zinc chloride, zinc acetate, zinc carbonate and zinc citrate trihydrate (i.e., zinc citrate (trihydrate)).

[0034] According to a specific embodiment of the present invention, in the pediatric formula food of the present invention, the bovine colostrum can be liquid bovine colostrum, bovine colostrum powder, or colostrum alkaline protein processed and prepared using bovine colostrum as raw material. Unless otherwise specified, the mass ratio or weight portion of bovine colostrum to lactoferrin described in the present invention is based on the amount of dry matter. In some specific embodiments of the present invention, the bovine colostrum is a powdered or finely crystalline product made from bovine colostrum as raw material, through processes such as sterilization, centrifugal defatting, and low-temperature drying; or it is colostrum alkaline protein made from bovine colostrum as raw material, through processes such as sterilization, defatting, centrifugal separation, removal of casein, α-lactalbumin, β-lactoglobulin, microfiltration, ultrafiltration, and freeze drying.

[0035] According to a specific embodiment of the present invention, in the pediatric formula food of the present invention, the lactoferrin can be a lactoferrin raw material from cow's milk, goat's milk and their products. For example, the raw material providing lactoferrin can be pure lactoferrin powder, or can include but not limited to milk alkaline protein, whole milk powder, skim milk powder, casein and whey protein powder. Unless otherwise specified, the ratio of the lactoferrin to other functional components in the composition of the present invention is based on the content of lactoferrin in the raw material.

[0036] According to a specific embodiment of the present invention, in the pediatric formula food of the present invention, the yeast β-glucan is produced by using brewer's yeast as raw material through extraction, acid-base treatment, spray drying and other steps, and meets the requirements of the announcement on approving 5 items such as golden camellia and Inula japonica (small black medicine) as new resource foods (No. 9 of 2010), and the β-glucan content used is ≥ 70%. Unless otherwise specified, the ratio of the yeast β-glucan to other functional components in the composition of the present invention is based on the β-glucan content in the raw materials.

[0037] According to a specific embodiment of the present invention, the pediatric formula food of the present invention, in addition to the zinc, lactoferrin, yeast β-glucan and bovine colostrum in the raw materials of the pediatric formula food, can also include other components of conventional infant formula food or children's reconstituted milk powder, mainly including protein, oil, carbohydrates, etc.

[0038] According to a specific embodiment of the present invention, the raw materials of the children's formula food of the present invention include:

[0039]

[0040]

[0041] The present invention also provides the use of the above-mentioned pediatric formula food in preparing products capable of promoting children's height growth.

[0042] In the above application, preferably, the method of promoting children's growth includes:

[0043] Prevent and / or alleviate weight loss caused by zinc deficiency or insufficient zinc intake;

[0044] Increase femur length; and / or

[0045] Add weight to the femur.

[0046] In the above application, preferably, based on the yeast β-glucan in the pediatric formula food, the application amount of the yeast β-glucan is 10-50 mg / day.

[0047] More preferably, based on the yeast β-glucan in the pediatric formula food, the amount of yeast β-glucan used is 11.5-49 mg / day, and further preferably 12.5-49 mg / day.

[0048] The "children" referred to in this manual refer to children between the ages of 0 and 6. According to different age groups and growth and development characteristics, "children" can be further divided into the following stages:

[0049] Infancy (0-1 years old): refers to children from birth to 1 year old.

[0050] Early childhood (1-3 years old): refers to children between 1 and 3 years old.

[0051] Childhood (3-18 years old): refers to children between 3 and 18 years old.

[0052] In the present invention, unless otherwise specified, the infants are infants aged 0-12 months; the toddlers are infants aged 1-3 years; and the children are children aged 36 months to under 7 years. In the present invention, unless otherwise specified, the infants are infants aged 0-12 months; the toddlers are infants aged 1-3 years; and the children are children aged 36 months to under 19 years, especially children under 7 years.

[0053] This definition applies to all parts of the present invention involving "children" to ensure that the technology, products or methods of the present invention meet the safety standards and applicability for use by children and adolescents. The design and use parameters of specific products or equipment can be appropriately adjusted according to the characteristics of different age groups to ensure their safety and effectiveness.

[0054] According to some specific embodiments of the present invention, in the present invention, the product can be any of the aforementioned foods, or a food obtained by further processing using the aforementioned pediatric formula food as a raw material without adding or with adding other substances.

[0055] The present invention has the following beneficial technical effects:

[0056] The present invention helps to promote the growth of children, prevent and / or alleviate weight loss, prevent and / or increase femur length, prevent and / or increase femur weight after lactoferrin, zinc, yeast beta-glucan and bovine colostrum in the raw material are mixed and compounded in a certain proportion, and the composition has an unexpected health effect within the preferred proportion range. BRIEF DESCRIPTION OF THE DRAWINGS

[0057] Figure 1 1 is the effect of different groups of experimental examples on femur length in a specific embodiment of the present invention.

[0058] Figure 2 1 is the effect of different groups of experimental examples on femoral weight in a specific embodiment of the present invention. DETAILED DESCRIPTION

[0059] Before further describing the specific embodiments of the present invention, it should be understood that the scope of protection of the present invention is not limited to the specific embodiments described below; it should also be understood that the terms used in the examples of the present invention are for describing the specific embodiments rather than for limiting the scope of protection of the present invention.

[0060] When the embodiments give numerical ranges, it should be understood that, unless otherwise specified in the present invention, both endpoints of each numerical range and any numerical value between the two endpoints can be selected. Unless otherwise defined, all technical and scientific terms used in the present invention have the same meaning as those generally understood by those skilled in the art. In addition to the specific methods, equipment, and materials used in the embodiments, according to the grasp of the prior art by those skilled in the art and the record of the present invention, any methods, equipment, and materials of the prior art similar or equivalent to the methods, equipment, and materials described in the embodiments of the present invention can also be used to realize the present invention.

[0061] Unless otherwise stated, the experimental methods, detection methods, and preparation methods disclosed in the present invention all adopt conventional techniques in the technical field.

[0062] In the embodiment, lactoferrin is conventional commercial lactoferrin powder or milk alkaline protein powder, wherein the content of lactoferrin is 95%; the milk alkaline protein powder has a milk alkaline protein content of ≥70%, a protein content of ≥90%, and a lactoferrin content of ≥38%. Bovine colostrum is conventional commercial bovine colostrum powder or commercial colostrum alkaline protein powder, wherein the protein content of bovine colostrum powder is 63.2%, and the immunoglobulin (IgG) content is ≥10%; the protein content of colostrum alkaline protein powder is ≥80%, and the immunoglobulin (IgG) content is ≥15%. The source of yeast β-glucan is conventional commercial yeast β-glucan powder, wherein the content of β-glucan is 75%.

[0063] Example 1

[0064] The present embodiment provides a children's formula milk powder food, in which the total protein content of the powdered formula food is 20.5g / 100g powder, the fat content is 13.5g / 100g powder, the carbohydrate content is 58.0g / 100g powder, the zinc content is 9.00mg / 100g powder, the lactoferrin content is 61.8mg / 100g powder, the bovine colostrum content is 360mg / 100g powder, and the yeast β-glucan content is 54.0mg / 100g powder.

[0065] This embodiment is achieved by compounding the following raw materials in parts by weight, and its raw material composition includes (preparing 1000 parts by weight):

[0066] 3400 parts of raw milk, 325 parts of skimmed milk powder, 215 parts of lactose, 15 parts of galacto-oligosaccharides, 6 parts of isomerized lactose liquid, 2.5 parts of compound vitamins, 1 part of compound minerals (including zinc sulfate), 0.65 parts of lactoferrin powder, 3.6 parts of bovine colostrum powder, and 0.72 parts of yeast β-glucan powder.

[0067] The children's formula milk powder of this embodiment is prepared by a dry-wet composite production process, which mainly includes: batching, preheating, homogenization, concentration and sterilization, spray drying, and obtaining a finished product. After testing, the various indicators of the finished product meet the standard requirements of children's formula milk powder.

[0068] The specific steps include:

[0069] The raw milk is inspected, roughly filtered, stored after cooling, and placed in a mixing tank after pasteurization (85°C, 15s); the large ingredients, small ingredients and other raw materials are fully mixed in proportion to ensure uniform distribution and stability of the formula; the mixed material is homogenized after filtering and removing impurities, with the homogenization temperature being 50°C and the pressure being 120bar; then, the homogenized material is concentrated, and the dry matter weight content of the concentrate is 50%; the concentrated material is sterilized at 85°C for 15s; the sterilized material is dried by a spray drying tower (inlet air temperature is 175°C, exhaust air temperature is 100°C, negative pressure is -8mmWG, high-pressure pump pressure is 200bar), and then introduced into a fluidized bed for secondary drying to obtain a powder.

[0070] Example 2

[0071] The present embodiment provides a children's formula milk powder food, in which the total protein content of the powdered formula food is 21.0g / 100g powder, the fat content is 18.0g / 100g powder, the carbohydrate content is 54.0g / 100g powder, the zinc content is 5.00mg / 100g powder, the lactoferrin content is 166.3mg / 100g powder, the bovine colostrum content is 198mg / 100g powder, and the yeast β-glucan content is 30.0mg / 100g powder.

[0072] This embodiment is achieved by compounding the following raw materials in parts by weight, and its raw material composition includes (preparing 1000 parts by weight):

[0073] 4400 parts of raw milk, 220 parts of skimmed milk powder, 200 parts of lactose, 15 parts of galacto-oligosaccharides, 6 parts of isomerized lactose liquid, 1.8 parts of compound vitamins, 1 part of compound minerals (including zinc sulfate), 0.75 parts of lactoferrin powder, 2.5 parts of milk alkaline protein powder, 1.98 parts of colostrum alkaline protein powder, and 0.4 parts of yeast β-glucan powder.

[0074] The children's formula milk powder of this embodiment is prepared by a dry-wet composite production process, which mainly includes: batching, preheating, homogenization, concentration and sterilization, spray drying, and obtaining a finished product. After testing, the various indicators of the finished product meet the standard requirements of children's formula milk powder.

[0075] The specific steps include:

[0076] The raw milk is inspected, roughly filtered, stored after cooling, and placed in a mixing tank after pasteurization (85°C, 15s); the large ingredients, small ingredients and other raw materials are fully mixed in proportion to ensure uniform distribution and stability of the formula; the mixed material is homogenized after filtering and removing impurities, with the homogenization temperature being 50°C and the pressure being 120bar; then, the homogenized material is concentrated, and the dry matter weight content of the concentrate is 50%; the concentrated material is sterilized at 85°C for 15s; the sterilized material is dried by a spray drying tower (inlet air temperature is 175°C, exhaust air temperature is 100°C, negative pressure is -8mmWG, high-pressure pump pressure is 200bar), and then introduced into a fluidized bed for secondary drying to obtain a powder.

[0077] Example 3

[0078] The present embodiment provides a children's formula milk powder food, in which the total protein content of the powdered formula food is 20.0g / 100g powder, the fat content is 18.0g / 100g powder; the carbohydrate content is 54.0g / 100g powder; the zinc content is 5.00mg / 100g powder; the lactoferrin content is 330.6mg / 100g powder; the bovine colostrum content is 200mg / 100g powder; and the yeast β-glucan content is 30.0mg / 100g powder.

[0079] This embodiment is achieved by compounding the following raw materials in parts by weight, and its raw material composition includes (preparing 1000 parts by weight):

[0080] 4400 parts of raw milk, 210 parts of skimmed milk powder, 200 parts of lactose, 15 parts of galacto-oligosaccharides, 6 parts of isomerized lactose liquid, 2.5 parts of compound vitamins, 1 part of compound minerals (including zinc sulfate), 1 part of lactoferrin powder, 6.2 parts of milk alkaline protein powder, 2 parts of bovine colostrum powder, and 0.4 parts of yeast β-glucan powder.

[0081] The children's formula milk powder of this embodiment is prepared by a dry-wet composite production process, which mainly includes: batching, preheating, homogenization, concentration and sterilization, spray drying, and obtaining a finished product. After testing, the various indicators of the finished product meet the standard requirements of children's formula milk powder.

[0082] The specific steps include:

[0083] The raw milk is inspected, roughly filtered, stored after cooling, and placed in a mixing tank after pasteurization (85°C, 15s); the large ingredients, small ingredients and other raw materials are fully mixed in proportion to ensure uniform distribution and stability of the formula; the mixed material is homogenized after filtering and removing impurities, with the homogenization temperature being 50°C and the pressure being 120bar; then, the homogenized material is concentrated, and the dry matter weight content of the concentrate is 50%; the concentrated material is sterilized at 85°C for 15s; the sterilized material is dried by a spray drying tower (inlet air temperature is 175°C, exhaust air temperature is 100°C, negative pressure is -8mmWG, high-pressure pump pressure is 200bar), and then introduced into a fluidized bed for secondary drying to obtain a powder.

[0084] Example 4

[0085] The present embodiment provides a children's formula milk powder food, in which the total protein content of the powdered formula food is 21.0g / 100g powder, the fat content is 13.5g / 100g powder, the carbohydrate content is 58.0g / 100g powder, the zinc content is 7.00mg / 100g powder, the lactoferrin content is 57.0mg / 100g powder, the bovine colostrum content is 320mg / 100g powder, and the yeast β-glucan content is 48.8mg / 100g powder.

[0086] This embodiment is achieved by compounding the following raw materials in parts by weight, and its raw material composition includes (preparing 1000 parts by weight):

[0087] 3400 parts of raw milk, 325 parts of skimmed milk powder, 210 parts of lactose, 15 parts of galacto-oligosaccharides, 6 parts of isomerized lactose liquid, 2.5 parts of compound vitamins, 1 part of compound minerals (including zinc sulfate), 1.5 parts of milk alkaline protein powder, 3.2 parts of bovine colostrum powder, and 0.65 parts of yeast β-glucan powder.

[0088] The children's formula milk powder of this embodiment is prepared by a dry-wet composite production process, which mainly includes: batching, preheating, homogenization, concentration and sterilization, spray drying, and obtaining a finished product. After testing, the various indicators of the finished product meet the standard requirements of children's formula milk powder.

[0089] The specific steps include:

[0090] The raw milk is inspected, roughly filtered, stored after cooling, and placed in a mixing tank after pasteurization (85°C, 15s); the large ingredients, small ingredients and other raw materials are fully mixed in proportion to ensure uniform distribution and stability of the formula; the mixed material is homogenized after filtering and removing impurities, with the homogenization temperature being 50°C and the pressure being 120bar; then, the homogenized material is concentrated, and the dry matter weight content of the concentrate is 50%; the concentrated material is sterilized at 85°C for 15s; the sterilized material is dried by a spray drying tower (inlet air temperature is 175°C, exhaust air temperature is 100°C, negative pressure is -8mmWG, high-pressure pump pressure is 200bar), and then introduced into a fluidized bed for secondary drying to obtain a powder.

[0091] Experimental study on the efficacy of nutritional composition in regulating body weight and bone development in rats

[0092] 1. Experimental animals and groups

[0093] Newly weaned (21 days) SPF SD male rats were housed in an animal room with an ambient temperature of 20-23°C, a relative humidity of 40%-70%, a 12-h artificial lighting / dark cycle, and a ventilation rate of ≥15 times / h.

[0094] The rat diet was prepared with reference to the current common experimental animal pure diet formula AIN-93G. Among them, casein was soaked in 1% disodium EDTA aqueous solution for many times to remove zinc, then rinsed with deionized ultrapure water and dried to prepare a zinc-deficient diet. A certain amount of zinc sulfate was added to the zinc-deficient diet to prepare diets with different zinc contents (5mg / kg, 10mg / kg, 30mg / kg), and the feed zinc concentration was detected by atomic absorption spectrophotometer standard method.

[0095] After 4 days of adaptive feeding, 56 SD rats were randomly divided into 7 groups according to body weight, with 8 rats in each group. Lactoferrin, bovine colostrum and yeast β-glucan were administered by gavage. The experimental groups are shown in the table below. The animals were weighed regularly and the intervention lasted for 5 weeks. After the experiment, the rats were killed by cervical dislocation and quickly dissected. The femur and other tissues were removed and properly preserved for subsequent experiments. The experimental groups are shown in Table 1.

[0096] Table 1

[0097]

[0098] Note: (1) Experimental Example 1 is the normal zinc control group; Experimental Example 2 is the zinc deficiency group, which is 1 / 6 of the normal zinc control group;

[0099] (2) The dosage per kilogram of body weight of rats is calculated based on their body weight, food intake, and zinc content in the feed during their growth. A zinc content of 10 mg / kg in the feed translates to a dosage of 1-1.5 mg / kg per kilogram of body weight of rats.

[0100] (3) Based on the average weight range of 10.3-50 kg for children aged 3-12 years, the daily supplementary amount of zinc is 1.5-12 mg, the daily supplementary amount of lactoferrin is 16-800 mg, the daily supplementary amount of bovine colostrum is 95-480 mg, and the daily supplementary amount of yeast β-glucan is 10-75 mg.

[0101] (II) Experimental methods

[0102] 1. Weight

[0103] Monitor the weight changes and diet of each rat, and calculate the animal weight during the experiment based on the animal weight and food intake.

[0104] 2. Femoral weight and femoral length

[0105] The femur length was measured and recorded using a ruler, and the femur weight was weighed on an analytical balance.

[0106] (III) Experimental results

[0107] 1. Effects of different experimental cases on the weight gain of growing rats

[0108] Weight gain is one of the important signs that describes whether rats grow and develop normally and whether their bodies are healthy. The results of weight changes in different groups showed that compared with Experimental Example 1, the weight gain of Experimental Examples 2-8 slowed down significantly after three weeks of intervention, and this trend continued until the fifth week, suggesting that reducing the zinc content in the feed, that is, zinc deficiency or insufficient zinc intake can lead to slow weight gain in growing rats and cause growth retardation.

[0109] Compared with Experimental Example 2, there was no significant difference in the weight of Experimental Example 4 after 3 weeks of intervention and 4 weeks of intervention, but the weight of Experimental Example 2 after 5 weeks of intervention was significantly higher than that of Experimental Example 2. Compared with Experimental Example 2, the weight of Experimental Examples 5-8 was significantly higher than that of Experimental Example 3 from the beginning of the 3rd week of intervention, and this trend of change continued until the 5th week; from the data of the 5th week of intervention, it can be seen that the slow weight gain caused by zinc deficiency or insufficient zinc intake in Experimental Examples 6-8 is better than that in Experimental Example 4, and the difference is significant; although there is no significant difference between Experimental Examples 6, 7 and 8, the weight of Experimental Examples 6-8 has an increasing trend with the increase of the enhanced dose, and Experimental Example 8 is closer to the normal feed control group of Experimental Example 1. Compared with Experimental Example 3, at the 5th week of intervention, Experimental Examples 6-8 were significantly higher than Experimental Example 3; compared with Experimental Example 5, at the 5th week of intervention, the weight of Experimental Examples 6 and 7 was significantly higher than that of Experimental Example 5.

[0110] The above results suggest that simply increasing the zinc content in the feed or lactoferrin + bovine colostrum + yeast β-glucan can alleviate the slow weight gain caused by zinc deficiency or insufficient zinc intake to a certain extent; but on the basis of increasing the zinc content, giving lactoferrin or lactoferrin + bovine colostrum + yeast β-glucan at the same time can further alleviate the slow weight gain caused by zinc deficiency or insufficient zinc intake, but the group technical effect of zinc + lactoferrin + bovine colostrum + yeast β-glucan nutritional composition is the best, and there is a certain synergistic effect. The effects of different experimental examples on the weight gain of growing rats are shown in Table 2.

[0111] Table 2

[0112]

[0113] 2. Effects of different experimental cases on bone development

[0114] In order to evaluate the effects of different experimental examples on the skeletal development of growth retardation animal models, the effects of 5-week intervention of each experimental example on the femur length and femur weight of rats were measured.

[0115] (1) Femoral length

[0116] The effects of different groups of embodiments on femur length in the specific embodiments of the present invention are as follows: Figure 1 As shown, compared with Experimental Example 1, the femur length of Experimental Example 2 decreased significantly, indicating that zinc deficiency or insufficient zinc intake can affect the development of femur length in growing rats, inhibit bone development, and cause femur length growth retardation. Compared with Experimental Example 2, although the femur length of Experimental Examples 3, 4 and 5 increased (by 2.7%, 2.2% and 3.6% respectively), there was no significant difference, indicating that simply increasing the zinc content in the feed, increasing lactoferrin + bovine colostrum + yeast β-glucan, and increasing zinc and lactoferrin at the same time have a tendency to alleviate the growth retardation of femur length, but there is no significant increase. Compared with Experimental Example 2, the femur length of Experimental Examples 6, 7 and 8 increased significantly, increasing by 5.2%, 6.3% and 6.9% respectively, and gradually approaching Experimental Example 1, and there was no significant difference between Experimental Example 1.

[0117] The above experimental results indicate that the zinc + lactoferrin + bovine colostrum + yeast β-glucan nutritional composition has a promoting effect on the femur development of growing rats and can significantly increase the femur length. There is a synergistic reaction between the components, which can synergistically increase the femur length and promote bone growth and development. With the increase of the dose, the femur length of the animals shows a trend of gradual recovery, showing a dose-dependent relationship. The effects of different experimental examples on the femur length of growing rats are shown in Figure 3.

[0118] Table 3

[0119] Group Femur length / cm Compared with Experiment 2, the increase in femur length / % Experimental Example 1 3.96±0.14a / Experimental Example 2 3.63±0.13d / Experimental Example 3 3.73±0.15bcd 2.7 Experimental Example 4 3.71±0.13cd 2.2 Experimental Example 5 3.76±0.11bcd 3.6 Experimental Example 6 3.82±0.09abc 5.2 Experimental Example 7 3.86±0.10abc 6.3 Experimental Example 8 3.88±0.10ab 6.9

[0120] (2) Femoral weight

[0121] The effects of different groups of embodiments on femoral weight in the specific embodiments of the present invention are as follows: Figure 2 As shown, compared with Experimental Example 1, the femur weight of Experimental Example 2 decreased significantly, indicating that zinc deficiency or insufficient zinc intake can affect the development of the femur of growing rats, inhibit bone development, and lead to a decrease in femur weight and slow femur growth. Compared with Experimental Example 2, although the femur weight of Experimental Example 4 increased (an increase of 22% compared with the control group), there was no significant difference; compared with Experimental Example 2, the femur weights of Experimental Examples 3 and Experimental Examples 5-8 increased significantly, increasing by 19.5%, 30.5%, 57.3%, 80.9%, and 93.9%, respectively; but compared with Experimental Examples 3 and 4, the femur weights of Experimental Examples 6-8 gradually increased, and the effects of Experimental Examples 6 and 7 gradually approached Experimental Example 1, and there was no significant difference between Experimental Example 1.

[0122] The above indicates that simply increasing the zinc content in the feed has a tendency to alleviate the growth retardation of femur length, but there is no significant increase; however, on the basis of increasing the zinc content, giving lactoferrin or lactoferrin + bovine colostrum + yeast β-glucan at the same time can further alleviate the decrease in femur weight caused by zinc deficiency or insufficient zinc intake, but the group technical effect of zinc + lactoferrin + bovine colostrum + yeast β-glucan nutritional composition is the best, and the effect is better than that of lactoferrin + bovine colostrum + yeast β-glucan group. There is a synergistic reaction between the components, which can synergistically increase the weight of the femur and promote bone growth and development. With the increase of the dose, the femur weight of the animal shows a trend of gradual recovery, and there is a certain synergistic effect and dose-effect relationship. The effects of different experimental examples on the femur weight of growing rats are shown in Table 4.

[0123] Table 4

[0124]

[0125] In summary, zinc deficiency or insufficient zinc intake can cause slow growth in body weight and femur length, decreased femur weight, affect bone development, and lead to growth retardation in growing rats. The zinc + lactoferrin + bovine colostrum + yeast β-glucan nutritional composition has significant effects on body weight gain, femur length and femur weight increase through a specific proportion and range, and the effect is better than that of the zinc alone fortified group, the lactoferrin alone fortified group, and the lactoferrin + bovine colostrum + yeast β-glucan group. There is a certain synergistic enhancement and dose-effect relationship between the components, which promotes the body weight and femur development of growing rats, promotes bone growth and development, improves or prevents growth retardation, and thus contributes to children's bone health and height development.

[0126] The above description of the embodiments is to facilitate the understanding and use of the invention by those skilled in the art. It is obvious that those skilled in the art can easily make various modifications to these embodiments and apply the general principles described herein to other embodiments without creative work. Therefore, the present invention is not limited to the above embodiments, and improvements and modifications made by those skilled in the art based on the disclosure of the present invention without departing from the scope of the present invention should be within the scope of protection of the present invention.

Claims

1. A pediatric formula food, wherein: The pediatric formula food comprises zinc, lactoferrin and yeast β-glucan, and the raw material of the pediatric formula food comprises bovine colostrum, and the mass ratio of zinc, lactoferrin, yeast β-glucan to bovine colostrum in the raw material of the pediatric formula food is 1.5-12:16-800:14-75:95-480 based on the dry matter mass of the zinc, lactoferrin, yeast β-glucan and bovine colostrum in the raw material of the pediatric formula food; Wherein, based on the dry weight of the pediatric formula food, the total protein content is 8g-30g / 100g, the fat content is 10g-35g / 100g, and the carbohydrate content is 35g-70g / 100g.

2. The pediatric formula food according to claim 1, wherein: The pediatric formula food is infant formula food or children's formula milk powder, preferably children's formula milk powder.

3. The pediatric formula food according to claim 1, wherein: The mass ratio of the zinc, lactoferrin, yeast β-glucan to the bovine colostrum in the raw materials of the pediatric formula food is 1.6-11.9:20-800:14.7-70:98.1-476; Preferably, the mass ratio of the zinc, lactoferrin, yeast β-glucan to the bovine colostrum in the raw materials of the pediatric formula food is 1.6-11.9:30-800:15-70:100-476.

4. The pediatric formula food according to claim 2, wherein: Based on the dry matter amount of the infant formula food, the total protein content is 8g-22g / 100g, the proportion of whey protein to total protein is 40%-75%, the fat content is 15g-33g / 100g, and the carbohydrate content is 50g-70g / 100g; preferably, based on the amount of dry matter of the infant formula food, the total protein content is 10g-18g / 100g, the proportion of whey protein to total protein is 40%-70%, the fat content is 18g-30g / 100g, and the carbohydrate content is 52g-60g / 100g; Calculated based on the dry matter amount of the children's formula milk powder, the total protein content is 16.5g-30g / 100g, the fat content is 10-35g / 100g, and the carbohydrate content is 35-70g / 100g; preferably, calculated based on the dry matter amount of the children's formula milk powder, the total protein content is 17g-25g / 100g, the fat content is 10-25g / 100g, and the carbohydrate content is 45-60g / 100g.

5. The pediatric formula food according to claim 1, wherein: The raw materials for providing zinc in the pediatric formula food include one or a combination of two or more of zinc sulfate, zinc gluconate, zinc glycinate, zinc oxide, zinc lactate, zinc citrate, zinc chloride, zinc acetate, zinc carbonate and zinc citrate trihydrate.

6. A method for preparing a pediatric formula food according to any one of claims 1 to 5, comprising the following steps: The raw milk is inspected, roughly filtered, stored after cooling, pasteurized at 90-100°C for 10-60s, placed in a mixing tank, and the raw materials are fully mixed in proportion to obtain a mixed material; the mixed material is homogenized after filtering and removing impurities, the homogenization temperature is 50-60°C, and the pressure is 120-200bar to obtain a homogenous material; the homogenized material is concentrated, and the dry matter weight content of the concentrate is 40-60%; the concentrated material is sterilized at 90-100°C for 10-60s to obtain a sterilized material; the sterilized material is dried by a spray drying tower, the air inlet temperature is 150-200°C, the exhaust temperature is 80-120°C, the negative pressure is -10 to -2mmWG, the high pressure pump pressure is 140-250bar, and then introduced into a fluidized bed for secondary drying to obtain a pediatric formula food.

7. Use of the pediatric formula food according to any one of claims 1 to 5 in the preparation of a product capable of promoting children's growth.

8. The use according to claim 7, wherein: The methods for promoting children's growth include: Prevent and / or alleviate weight loss caused by zinc deficiency or insufficient zinc intake; Increase femur length; and / or Add weight to the femur.

9. The use according to claim 7 or 8, wherein: Calculated on the basis of the yeast beta-glucan in the pediatric formula food, the application amount of the yeast beta-glucan is 10-50 mg / day.

10. The use according to claim 9, wherein: Calculated on the basis of the yeast β-glucan in the pediatric formula food, the application amount of the yeast β-glucan is 11.5-49 mg / day, preferably 12.5-49 mg / day.

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