Traditional Chinese medicine mixture for treating chronic atrophic gastritis and preparation method thereof

Abstract

The invention relates to a traditional Chinese medicine mixture for treating chronic atrophic gastritis and a preparation method thereof. The traditional Chinese medicine mixture is prepared from the following raw materials in parts by weight: 10-20 parts of codonopsis pilosula, 10-20 parts of radix polygonati officinalis, 7-17 parts of pinellia ternate, 10-20 parts of poria cocos, 15-25 parts of raw rhizoma atractylodis macrocephalae, 7-17 parts of rhizoma cyperi, 1-11 parts of pseudo-ginseng powder, 25-35 parts of spina gleditsiae, 10-20 parts of edible tulip, 25-35 parts of oldenlandia diffusa and 5-15 parts of raw liquorice. The traditional Chinese medicine composition follows the medication principle of monarch, minister, assistant and guide of traditional Chinese medicines, and the two raw materials of codonopsis pilosula and polygonatum odoratum in the formula are compatible to serve as monarch drugs. Pinellia ternate, poria cocos, raw atractylodes macrocephala koidz and cyperus rotundus are compatible and are used as ministerial drugs. Pseudo-ginseng powder, spina gleditsiae, oldenlandia diffusa and edible tulip are used as adjuvant drugs. And the raw liquorice is used as a conductant drug for harmonizing the medicines. According to the traditional Chinese medicine composition, the medicines are compatible, the medicines are movable in the static, tonify without stagnation, tonify mainly and dredge, dredge and tonify simultaneously, and on the basis of tonifying qi, the medicines are matched with the medicines for promoting blood circulation to remove blood stasis, regulating qi to remove stasis and clearing away heat and toxic materials to achieve the effects of tonifying qi, dispersing blood stasis and detoxifying, can tonify deficiency, dredge collaterals and tonify qi, and can be used for chronic atrophic gastritis (precancerous lesion) and the like.

Description

Technical Field

[0001] The invention relates to the field of traditional Chinese medicines, and in particular to a traditional Chinese medicine mixture for treating chronic atrophic gastritis and a preparation method thereof. Background Art

[0002] Atrophic gastritis, also known as chronic atrophic gastritis, is a chronic digestive system disease characterized by atrophy of gastric mucosal epithelium and glands, decreased number, thinning of gastric mucosa, thickening of mucosal basal layer, or accompanied by pyloric gland metaplasia and intestinal gland metaplasia, or atypical hyperplasia. Clinically, it often manifests as upper abdominal pain, fullness, belching, loss of appetite, or weight loss, anemia, etc., which are non-specific. It is a multi-pathogenic disease or precancerous lesion.

[0003] The etiology and pathogenesis of chronic atrophic gastritis are still unclear. It is generally believed that chronic inflammation of the gastric mucosa is caused by immune factors, bile reflux, biological factors, drug factors, acute gastritis, oral and nasopharyngeal infections, etc., which repeatedly damage the surface of the gastric mucosa and lead to atrophy of the gastric secretory glands, discoloration and thinning of the gastric mucosa, exposed blood vessels, reduced gastric acid secretion, weakened digestive function, and gastric motility disorders over a long period of time, thus forming chronic atrophic gastritis.

[0004] Modern medicine lacks effective treatment for chronic atrophic gastritis. Most of them are symptomatic treatments, which can only relieve some of the clinical symptoms. The long-term efficacy is not ideal, and there are disadvantages such as large side effects of drug treatment. For example, the use of proton pump inhibitors only has a certain effect on inhibiting gastric acid secretion. Long-term use will cause headaches, abdominal pain, and constipation, which is not conducive to treatment. Compared with Western medicine, Chinese medicine treatment is good at regulating overall functions and has unique advantages in clinical treatment. In the category of chronic atrophic gastritis, Chinese medicine "stomach distension", "deficiency distension", "distension", "stomach pain", "noisy" and other diseases are mostly treated from the aspects of qi stagnation and blood stasis, phlegm and dampness obstruction, spleen and stomach dampness and heat, blood stasis and heat toxicity, etc., with the treatment methods of regulating qi and activating blood circulation, drying dampness and resolving phlegm, clearing dampness and heat, and removing blood stasis and clearing heat, and the prescriptions and medications are quite effective. Chronic atrophic gastritis patients often feel upper abdominal pain, fullness, belching, loss of appetite, or weight loss, anemia, traditional Chinese medicine treatment of atrophic gastritis precancerous lesions, overall regulation, few side effects, low recurrence rate, high safety, easy to accept by patients, is one of the simple and effective methods for treating atrophic gastritis precancerous lesions, with good application prospects and clinical value. Therefore, the present invention provides a kind of Chinese medicine mixture that can tonify deficiency, dredge meridians, invigorate qi and remove blood stasis, and is suitable for treating chronic atrophic gastritis (precancerous lesions) and the like. Summary of the invention

[0005] The purpose of the present invention is to obtain a Chinese medicine mixture for treating chronic atrophic gastritis with significant efficacy, wide application and modern new dosage form and a preparation method thereof in view of the treatment limitations of chronic atrophic gastritis.

[0006] The technical scheme adopted by the present invention is a traditional Chinese medicine mixture for treating chronic atrophic gastritis, which is composed of the following raw materials in parts by weight: 10-20 parts of Codonopsis pilosula, 10-20 parts of Polygonatum odoratum, 7-17 parts of Pinellia ternata, 10-20 parts of Poria cocos, 15-25 parts of raw Atractylodes macrocephala, 7-17 parts of Cyperus rotundus, 1-11 parts of Panax notoginseng powder, 25-35 parts of Gleditsia sinensis spines, 10-20 parts of Psoralea corylifolia, 25-35 parts of Hedyotis diffusa and 5-15 parts of raw liquorice.

[0007] Furthermore, it is composed of the following raw materials in parts by weight: 15 parts of Codonopsis pilosula, 15 parts of Polygonatum odoratum, 12 parts of Pinellia ternata, 15 parts of Poria cocos, 20 parts of raw Atractylodes macrocephala, 12 parts of Cyperus rotundus, 6 parts of Panax notoginseng powder, 30 parts of Gleditsia sinensis, 15 parts of Psoralea corylifolia, 30 parts of Hedyotis diffusa, and 10 parts of raw licorice.

[0008] Furthermore, it is composed of the following raw materials in parts by weight: 10 parts of Codonopsis pilosula, 10 parts of Polygonatum odoratum, 12 parts of Pinellia ternata, 15 parts of Poria cocos, 20 parts of raw Atractylodes macrocephala, 12 parts of Cyperus rotundus, 6 parts of Panax notoginseng powder, 30 parts of Gleditsia sinensis, 15 parts of Psoralea corylifolia, 30 parts of Hedyotis diffusa, and 10 parts of raw licorice.

[0009] Furthermore, it is composed of the following raw materials in parts by weight: 10 parts of Codonopsis pilosula, 10 parts of Polygonatum odoratum, 17 parts of Pinellia ternata, 20 parts of Poria cocos, 25 parts of raw Atractylodes macrocephala, 17 parts of Cyperus rotundus, 11 parts of Panax notoginseng powder, 35 parts of Gleditsia sinensis, 20 parts of Psoralea corylifolia, 35 parts of Hedyotis diffusa, and 15 parts of raw licorice.

[0010] Furthermore, it is composed of the following raw materials in parts by weight: 20 parts of Codonopsis pilosula, 20 parts of Polygonatum odoratum, 7 parts of Pinellia ternata, 10 parts of Poria cocos, 15 parts of raw Atractylodes macrocephala, 7 parts of Cyperus rotundus, 1 part of Panax notoginseng powder, 25 parts of Gleditsia sinensis, 10 parts of Psoralea corylifolia, 25 parts of Hedyotis diffusa, and 5 parts of raw licorice.

[0011] The present invention also provides a method for preparing a Chinese medicine mixture for treating chronic atrophic gastritis, comprising the following steps:

[0012] (1) Codonopsis pilosula, Polygonatum odoratum, Pinellia tuber, Poria cocos, raw Atractylodes macrocephala, Cyperus rotundus, notoginseng powder, Gleditsia sinensis, Psoralea corylifolia, Hedyotis diffusa and raw Licorice root are mixed according to the weight proportions, and weighed for later use;

[0013] (2) Take Codonopsis pilosula, Polygonatum odoratum, Pinellia ternata, Poria cocos, Atractylodes macrocephala, Cyperus rotundus, Gleditsia sinensis, Psoralea corylifolia, Hedyotis diffusa and Licorice root, add 8-12 times the amount of water, soak for 0.5-1.5 hours, and perform the first heating and decoction for 1.5 hours;

[0014] (3) adding Panax notoginseng powder to the mixture, filtering, and collecting the first extract and the medicinal residue;

[0015] (4) adding 6-10 times the amount of water to the medicinal residue, heating and boiling for a second time for 1 hour, filtering, and collecting a second extract;

[0016] (5) combining and mixing the first extract and the second extract, heating and concentrating the mixture to obtain a concentrated solution;

[0017] (6) The concentrated liquid is sterilized in a water bath to obtain the finished product.

[0018] Wherein, in step (3), the Panax notoginseng powder is added 5-10 minutes before the end of the first heating and boiling.

[0019] Wherein, in step (3), Panax notoginseng powder is added after the first heating and decocting is completed.

[0020] Among them, after step (5), the following operations may be performed: sampling the concentrated liquid, and after the sampled concentrated liquid is inspected and found to be qualified, the concentrated liquid is filled and sealed by an automatic filling machine.

[0021] Among them, the inspection passing standard is pH value of 4.0-6.0 and concentrated relative density of 1.01-1.05.

[0022] The pharmacological effects of the eleven medicinal materials in the formula of the present invention are as follows:

[0023] (1) Codonopsis pilosula, [Nature and flavor and meridians] Sweet, neutral, spleen and lung meridians. [Functions and indications] It has the effects of strengthening the spleen and lungs, promoting the production of body fluids and nourishing blood. It is often used to treat symptoms such as spleen and lung qi deficiency, gastrointestinal discomfort, qi and blood deficiency, qi and body fluid damage, internal heat and thirst. Modern studies have shown that the relevant compatibility, single herb, effective parts and components of Codonopsis pilosula can effectively protect and repair the gastric mucosa.

[0024] (2) Polygonatum odoratum, [nature and flavor and meridians] sweet, slightly cool in nature, enters the lung and large intestine meridians. [Functions and indications] It has the effects of moistening the lungs and resolving phlegm, clearing away heat and removing dampness, eliminating carbuncle and promoting urination. It can treat phlegm-heat cough, lung carbuncle and intestinal carbuncle, beriberi edema, stranguria, damp-heat diarrhea in women, etc.

[0025] (3) Pinellia, [Nature and flavor and meridians] Spicy, warm in nature, enters the spleen, stomach, and lung meridians. [Functions and indications] It has the effects of drying dampness and resolving phlegm, relieving adverse reactions and stopping vomiting, and dissolving lumps and knots. It is used for damp phlegm and cold phlegm, cough and asthma with excessive phlegm, phlegm and dizziness, wind phlegm and dizziness, phlegm and headache, vomiting and nausea, chest and abdominal distension, plum pit qi; external treatment of carbuncle and phlegm nodules. Modern research shows that Pinellia can inhibit gastric juice secretion and pepsin activity, reduce total acidity and free acidity of gastric juice, protect and promote repair of acute mucosal damage, and has a significant preventive and therapeutic effect on chronic acetic acid type, indomethacin type, and pyloric ligation type ulcers.

[0026] (4) Poria cocos, [nature and flavor and meridians] taste sweet and light, neutral in nature, and enters the heart, lung, spleen, and kidney meridians. [Functions and indications] It has the effects of astringing the intestines and stopping diarrhea, clearing away heat and dampness, and is mainly used to treat diarrhea caused by spleen deficiency. It is one of the commonly used Chinese medicines with the same medicinal and edible properties in traditional Chinese medicine. The Jingyue Complete Works says: "The root of diarrhea is all due to the spleen and stomach. The stomach is the sea of ​​water and grain, and the spleen is responsible for transportation and transformation. If the spleen is invigorated and the stomach is in harmony, the water and grain will be decomposed, and the qi and blood will be transformed to circulate in the body." It is believed that spleen and stomach dysfunction is the main factor in the occurrence of this disease, which is consistent with the indications of Poria cocos. Studies have shown that the pharmacological effects of Poria cocos mainly include immunomodulatory effects, anti-inflammatory effects, and anti-tumor effects.

[0027] (5) Raw Atractylodes macrocephala, [nature and flavor] sweet, bitter, warm in nature, enters the spleen and stomach meridians. [Functions and indications] Shennong's Herbal Classic

[16] says: "It tastes bitter and warm. It treats wind-cold-dampness arthralgia, stiff muscles, spasms, jaundice, sweating, heat removal, and digestion." Leigong Paoyao Yaoxingjie says: "It tastes bitter and sweet, warm in nature, non-toxic, and enters the spleen meridian. It removes dampness, promotes urination, and strengthens the spleen and stomach.

[0028] (6) Cyperus rotundus, [nature and flavor and meridians] It tastes pungent, slightly bitter, slightly sweet, and is neutral in nature. It enters the liver, spleen, and triple burner meridians. It contains a variety of chemical components. [Functions and indications] Its main effects are to soothe the liver and regulate qi, regulate menstruation and relieve pain. It has a high medicinal value and is widely used in traditional Chinese medicine in my country. It is an important Chinese medicine in clinical practice.

[0029] (7) Panax notoginseng, [Nature and flavor] Sweet, slightly bitter, warm in nature, and enters the liver meridian, stomach meridian, heart meridian, lung meridian, and large intestine meridian. [Functions and indications] It has the effects of removing blood stasis and stopping bleeding, promoting blood circulation and relieving pain, and at the same time has the effect of nourishing blood and has significant hematopoietic function. Modern research shows that Panax notoginseng has strong anti-tumor activity, enhances the learning and memory of mice, has a two-way regulation of hemostasis and blood circulation, and has anti-tumor effects.

[0030] (8) Gleditsia sinensis, [Nature and flavor and meridians] Spicy, warm in nature, enters the liver and stomach meridians. [Functions and indications] In clinical Chinese medicine, it is used to reduce swelling, detoxify, discharge pus, treat inflammation and skin diseases, etc. It has anti-tumor, antibacterial, antioxidant and immunomodulatory functions. .

[0031] (9) Tripterygium wilfordii, [Nature and flavor and meridians] Sweet, slightly spicy, cool in nature, enters the liver and spleen meridians. [Functions and indications] It has the effects of clearing away heat and detoxifying, eliminating carbuncle and dispersing nodules, and can treat scrofula, phlegm nodules, masses and lumps. Modern studies have shown that it has anti-tumor effects, and its anti-tumor effects are mainly concentrated in cytotoxicity, inducing tumor cell apoptosis, and inhibiting tumor cell invasion and metastasis.

[0032] (10) Hedyotis diffusa, [Nature and flavor] Cold in nature, bitter, sweet and light in taste, enters the heart, liver, spleen and large intestine meridians. [Functions and indications] Clears away heat and detoxifies, promotes dampness and relieves stranguria. Studies have reported that Hedyotis diffusa has multiple pharmacological activities such as anti-tumor, anti-inflammatory and antibacterial, antioxidant, and immunity-enhancing.

[0033] (11) Raw Licorice, Licorice, [Nature and Flavor and Meridians] Sweet, neutral in nature, enters the heart, lung, spleen, and stomach meridians. [Functions and Indications] It has a sweet taste, "can rise or fall, float or sink, go inside or outside, have harmony or soothing effects, have tonifying or purging effects", can tonify, harmonize, soothe, and detoxify, and has a wide range of uses. Raw licorice is slightly cool, has the effect of clearing heat and purging fire, and can be used in heat-clearing prescriptions to enhance the effect of clearing heat and purging fire, or to benefit qi without increasing heat. Licorice is very sweet and has a specialty in detoxification. It is known as the "holy medicine for detoxification". It can not only "detoxify a hundred drugs", but also detoxify sores, ulcers, and carbuncles. Licorice is sharp in nature when used raw, can circulate, and has a greater detoxification power, so raw licorice is often used for detoxification.

[0034] The Chinese medicine mixture for treating chronic atrophic gastritis provided by the present invention comprises codonopsis pilosula, which can nourish the spleen and stomach, strengthen the spleen without being dry, and nourish stomach yin without being wet; polygonatum odoratum controls the abdominal distension caused by evil qi, and plays a role of strengthening the body to improve the function of the stomach, and the two are the main medicines. Pinellia ternata dries dampness and resolves phlegm, descends adverse qi and stops vomiting, and eliminates lumps and resolves knots; Poria cocos has many functions of promoting water circulation, and it is indispensable to benefit the heart and spleen; Atractylodes macrocephala tastes bitter, sweet, and warm in nature, and enters the spleen and stomach meridians, strengthens the spleen and replenishes qi, dries dampness and promotes diuresis; Cyperus rotundus tastes pungent, slightly bitter, and slightly sweet, and is flat in nature, and enters the liver, spleen, and triple burner meridians, and plays a role of soothing the liver and regulating qi, regulating menstruation and relieving pain. Codonopsis pilosula, polygonatum odoratum, and Cyperus rotundus are used together to strengthen the body without hindering evil qi, expel evil qi without hurting the body, and strengthen the main medicine to enhance the function of strengthening the spleen and removing dampness, and the four are the ministerial medicines. Panax notoginseng powder tastes sweet, slightly bitter, warm, can dissipate blood stasis without hurting the body, stop bleeding without leaving blood stasis, and has the effects of promoting blood circulation and removing blood stasis, stopping bleeding and relieving pain; Gleditsiae chinensis and Hedyotis diffusa can clear away heat and toxic substances, promote blood circulation and qi, promote blood circulation and remove blood stasis, and Psoralea corylifolia can enter the liver, stomach, and lung meridians, clear away heat and toxic substances, eliminate carbuncle and disperse knots, and the four are adjuvants. Licorice is sweet and flat in nature, enters the twelve meridians, nourishes the spleen and moistens the lungs, replenishes qi and restores pulse, relieves urgency and stops pain, clears away heat and detoxifies, and harmonizes the properties of the medicine as a guiding drug. The compatibility of various drugs is static and dynamic, replenishes without stagnation, mainly replenishes, and uses communication, which is contained in replenishment, and the communication and replenishment are applied simultaneously. On the basis of replenishing qi, it is matched with products that promote blood circulation and remove blood stasis, regulate qi and disperse knots, and clear away heat and toxic substances, replenish deficiency and eliminate excess, treat the symptoms and the root cause at the same time, and play the effect of replenishing qi, removing blood stasis and detoxifying.

[0035] Compared with the prior art, the present invention has the following beneficial effects: the present invention provides a Chinese medicine mixture Chinese medicine lotion for treating chronic atrophic gastritis, with Codonopsis pilosula, Polygonatum odoratum, Pinellia tuber, Poria cocos, Raw Atractylodes macrocephala, Cyperus rotundus, Panax notoginseng powder, Gleditsia sinensis, Hedyotis diffusa, Tripterygium wilfordii and Raw Licorice as raw materials, following the principle of "monarch, minister, assistant and messenger" of Chinese medicine, Codonopsis pilosula in the prescription strengthens the spleen and lungs, promotes fluid and nourishes blood; Polygonatum odoratum moistens the lungs and resolves phlegm, clears away heat and infiltrates dampness, eliminates carbuncle and promotes urination, and the two raw materials are used as monarch drugs. Pinellia tuber dries dampness and resolves phlegm, reduces adverse effects and stops vomiting, eliminates lumps and disperses knots; Poria cocos astringes the intestines and stops diarrhea, clears away heat and dries dampness; Raw Atractylodes macrocephala strengthens the spleen and replenishes qi, dries dampness and promotes diuresis; Cyperus rotundus soothes the liver and regulates qi, regulates menstruation and relieves pain, and the four raw materials are used as minister drugs. Panax notoginseng powder has the effects of removing blood stasis and stopping bleeding, promoting blood circulation and relieving pain, and replenishing blood; Gleditsia sinensis has the effects of reducing swelling, detoxification, and pus discharge; Hedyotis diffusa has the effects of clearing heat and detoxicating, promoting dampness and relieving stranguria; Psoralea corylifolia has the effects of clearing heat and detoxicating, eliminating carbuncle and dispersing knots, and the four raw materials are used as adjuvants. Raw liquorice has the effects of clearing heat and detoxicating, relieving urgency and relieving pain, and harmonizing various medicines as a guiding medicine. The compatibility of various medicines is dynamic in stillness, replenishing without stagnation, mainly replenishing, using communication as the main function, implying communication in replenishing, and combining communication and replenishing. On the basis of replenishing qi, it is equipped with products of promoting blood circulation and removing blood stasis, regulating qi and dispersing knots, and clearing heat and detoxicating, replenishing deficiency and removing excess, treating the symptoms and the root cause at the same time, and playing the effects of invigorating qi, removing blood stasis and detoxifying. The present invention can replenish deficiency, dredge collaterals, and invigorate qi and remove blood stasis. It is used for chronic atrophic gastritis (precancerous lesions), etc. Symptoms: fullness in the stomach, or pain in a fixed place, stomachache refuses to be pressed, noisy, black stools, dark complexion, dark red tongue or with petechiae, ecchymoses, and stringy and astringent pulse. DETAILED DESCRIPTION

[0036] The technical scheme of the present invention is further described below in conjunction with specific embodiments. However, it should be understood by those skilled in the art that the following examples are only used to illustrate the present invention and should not be regarded as limiting the present invention. The specific conditions not specified in the examples are carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used, unless otherwise specified, are conventional products obtained through commercial channels.

[0037] (1) Implementation Case 1

[0038] 15 parts of Codonopsis pilosula, 15 parts of Polygonatum odoratum, 12 parts of Pinellia ternata, 15 parts of Poria, 20 parts of Raw Atractylodes macrocephala, 12 parts of Cyperus rotundus, 6 parts of Notoginseng powder, 30 parts of Gleditsia sinensis, 15 parts of Psoralea corylifolia, 30 parts of Oldenlandia diffusa, and 10 parts of Raw Licorice.

[0039] Specifically, Codonopsis pilosula 15g, Polygonatum odoratum 15g, Pinellia ternata 12g, Poria 15g, Raw Atractylodes macrocephala 20g, Cyperus rotundus 12g, Panax notoginseng powder 6g, Gleditsia sinensis 30g, Trillium gracile 15g, Hedyotis diffusa 30g, and Raw Licorice 10g.

[0040] Weigh the prescription Chinese medicine slices according to the preparation amount, and after checking, wrap them in non-woven bags to make medicine bags. Put the medicine bags except raw mint into the Chinese medicine extraction tank in turn and add 10 times the amount of water to soak for 1 hour. After the medicine bag is completely soaked, start the first heating and decoction for 1.5 hours. Add Panax notoginseng powder 5 minutes before or after the first heating and decoction is completed, filter, and collect the first extract. Continue to add 8 times the amount of water, heat and decoct for the second time for 1 hour, filter, collect the second extract, and combine the two extracts. Heat and concentrate the combined extract to 1000ml to obtain a concentrated solution. Sample the concentrated solution for semi-finished product inspection. The inspection standard is that the pH value of the medicine solution is 4.0 and the concentrated relative density is 1.01; after the inspection is qualified, the concentrated solution is filled and filled by an automatic filling machine (200ml / bottle); after the canning is completed, it is sterilized in a water bath at 100℃ for 30 minutes, and then labeled, checked and put into storage.

[0041] (2) Implementation Case 2

[0042] 10 parts of Codonopsis pilosula, 10 parts of Polygonatum odoratum, 12 parts of Pinellia ternata, 15 parts of Poria, 20 parts of Raw Atractylodes macrocephala, 12 parts of Cyperus rotundus, 6 parts of Notoginseng powder, 30 parts of Gleditsia sinensis, 15 parts of Psoralea corylifolia, 30 parts of Oldenlandia diffusa, and 10 parts of Raw Licorice.

[0043] Specifically, Codonopsis pilosula 10g, Polygonatum odoratum 10g, Pinellia ternata 12g, Poria 15g, Raw Atractylodes macrocephala 20g, Cyperus rotundus 12g, Panax notoginseng powder 6g, Gleditsia sinensis 30g, Trillium gracile 15g, Hedyotis diffusa 30g, and Raw Licorice 10g.

[0044] Weigh the prescription Chinese medicine slices according to the preparation amount, and after checking, wrap them in non-woven bags to make medicine bags. Put the medicine bags except raw mint into the Chinese medicine extraction tank in turn and add 8 times the amount of water to soak for 0.5 hours. After the medicine bag is completely soaked, start the first heating and decoction for 1.5 hours. Add Panax notoginseng powder 8 minutes before the first heating and decoction is completed or after the first heating and decoction is completed, filter, and collect the first extract. Continue to add 6 times the amount of water, heat and decoct for the second time for 1 hour, filter, collect the second extract, and combine the two extracts. Heat and concentrate the combined extract to 1000ml to obtain a concentrated solution. Sample the concentrated solution for semi-finished product inspection. The inspection standard is that the pH value of the medicine solution is 5.0 and the concentrated relative density is 1.03; after the inspection is qualified, the concentrated solution is filled and filled by an automatic filling machine (200ml / bottle); after the canning is completed, it is sterilized in a water bath at 100℃ for 30 minutes, and then labeled, checked and put into storage.

[0045] (3) Implementation Case 3

[0046] 10 parts of Codonopsis pilosula, 10 parts of Polygonatum odoratum, 17 parts of Pinellia ternata, 20 parts of Poria, 25 parts of Raw Atractylodes macrocephala, 17 parts of Cyperus rotundus, 11 parts of Notoginseng powder, 35 parts of Gleditsia sinensis, 20 parts of Psoralea corylifolia, 35 parts of Oldenlandia diffusa, and 15 parts of Raw Licorice.

[0047] Specifically, Codonopsis pilosula 10g, Polygonatum odoratum 10g, Pinellia ternata 17g, Poria 20g, Raw Atractylodes macrocephala 25g, Cyperus rotundus 17g, Panax notoginseng powder 11g, Gleditsia sinensis 35g, Trillium gracile 20g, Hedyotis diffusa 35g, and Raw Licorice 15g.

[0048] Weigh the prescription Chinese medicine slices according to the preparation amount, and after checking, wrap them in non-woven bags to make medicine bags. Put the medicine bags except raw mint into the Chinese medicine extraction tank in turn and add 12 times the amount of water to soak for 1.5 hours. After the medicine bag is completely soaked, start the first heating and decoction for 1.5 hours. Add Panax notoginseng powder 5 minutes before or after the first heating and decoction is completed, filter, and collect the first extract. Continue to add 10 times the amount of water, heat and decoct for the second time for 1 hour, filter, collect the second extract, and combine the two extracts. Heat and concentrate the combined extract to 1000ml to obtain a concentrated solution. Sample the concentrated solution for semi-finished product inspection. The inspection standard is that the pH value of the medicine solution is 6.0 and the concentrated relative density is 1.05; after the inspection is qualified, the concentrated solution is filled and filled by an automatic filling machine (200ml / bottle); after the canning is completed, it is sterilized in a water bath at 100℃ for 30 minutes, and then labeled, checked and put into storage.

[0049] (4) Implementation Case 4

[0050] 20 parts of Codonopsis pilosula, 20 parts of Polygonatum odoratum, 7 parts of Pinellia ternata, 10 parts of Poria, 15 parts of Raw Atractylodes macrocephala, 7 parts of Cyperus rotundus, 1 part of Notoginseng powder, 25 parts of Gleditsia sinensis, 10 parts of Psoralea corylifolia, 25 parts of Oldenlandia diffusa, and 5 parts of Raw Licorice.

[0051] Specifically, Codonopsis pilosula 20g, Polygonatum odoratum 20g, Pinellia ternata 7g, Poria 10g, Raw Atractylodes macrocephala 15g, Cyperus rotundus 7g, Panax notoginseng powder 1g, Gleditsia sinensis 25g, Trillium gracile 10g, Hedyotis diffusa 25g, and Raw licorice 5g.

[0052] Weigh the prescription Chinese medicine slices according to the preparation amount, and after checking, wrap them in non-woven bags to make medicine bags. Put the medicine bags except raw mint into the Chinese medicine extraction tank in turn and add 10 times the amount of water to soak for 1 hour. After the medicine bag is completely soaked, start the first heating and decoction for 1.5 hours. Add Panax notoginseng powder 5 minutes before or after the first heating and decoction is completed, filter, and collect the first extract. Continue to add 8 times the amount of water, heat and decoct for the second time for 1 hour, filter, collect the second extract, and combine the two extracts. Heat and concentrate the combined extract to 1000ml to obtain a concentrated solution. Sample the concentrated solution for semi-finished product inspection. The inspection standard is that the pH value of the medicine solution is 4.0 and the concentrated relative density is 1.01; after the inspection is qualified, the concentrated solution is filled and filled by an automatic filling machine (200ml / bottle); after the canning is completed, it is sterilized in a water bath at 100℃ for 30 minutes, and then labeled, checked and put into storage.

[0053] Clinical observation of the Chinese medicine mixture for treating chronic atrophic gastritis described in the present invention:

[0054] 1. General information: The cases observed in this study were from outpatients of Zhongwei Traditional Chinese Medicine Hospital. This study included 100 patients with chronic atrophic gastritis.

[0055] 2. Usage and dosage of the present invention: Oral administration, 40-70 ml each time, 3 times a day, or as directed by a doctor.

[0056] 3. Precautions for use of the present invention: 1. Avoid smoking, drinking, spicy, cold, and greasy food, and eat a light diet; 2. Do not take nourishing Chinese medicine while taking the medicine. If you are taking other medicines, you need to consult a doctor or pharmacist before using this product; 3. People with serious chronic diseases such as heart disease, liver disease, and kidney disease should take the product under the guidance of a doctor; 4. Children, pregnant women, breastfeeding women, and the elderly and infirm should take the product under the guidance of a doctor; 5. People who are allergic to this product are prohibited from using it, and those with allergic constitutions should use it with caution; 6. This product must be kept out of reach of children, and children must use it under adult supervision; 7. Take it strictly according to the usage and dosage; 8. This product is prohibited from use when its properties change.

[0057] 4. TCM diagnostic criteria

[0058] (1) Spleen and stomach weakness syndrome

[0059] Symptoms: dull pain in the stomach, preference for warmth and pressure, distension after eating, belching, occasional vomiting of clear water, poor appetite, loose stools, fatigue, sallow complexion, pale tongue with white coating, and weak pulse.

[0060] Analysis: The spleen and stomach are the foundation of the acquired constitution. If the spleen and stomach are weak, they cannot transport and transform water, so there will be dull pain in the stomach, bloating after eating, and poor appetite. The spleen and stomach are weak and cold, so they will feel relieved by warmth, so they like warmth and pressure. If the stomach qi goes up, there will be belching and vomiting of clear water. If the spleen is weak and cannot transport and transform water and moisture, and cannot distinguish between clear and turbid, there will be loose stools. The production of qi and blood is insufficient, so there will be fatigue, sallow complexion. Pale tongue with white coating and weak pulse are also signs of weak spleen and stomach.

[0061] (2) Stomach Yin Deficiency Syndrome

[0062] Symptoms: dull burning pain in the stomach, feeling hungry but not wanting to eat, dry mouth and throat, dry and hard stools, red tongue with little fluid, and a thready and rapid pulse.

[0063] Analysis: Deficiency of stomach yin causes the stomach to lose nourishment, so there is a dull burning pain in the epigastrium; insufficient stomach yin causes internal disturbance of virtual fire, resulting in a feeling of hunger, but there is no real evil in the stomach, so there is no appetite; yin fluid cannot flow upward, resulting in dry mouth and throat; the intestines lose moisture, so the stool is dry and hard; a red tongue with little fluid and a thin and rapid pulse are signs of yin deficiency and internal heat.

[0064] (3) Liver-stomach disharmony syndrome

[0065] Symptoms: fullness or pain in the epigastric region, pain in the ribs, frequent belching, which may occur or worsen due to emotional factors, thin white tongue coating, and wiry pulse.

[0066] Analysis: Emotional discomfort, liver qi stagnation, and stomach dysfunction result in fullness or pain in the epigastric region, and flank pain. Frequent belching due to upward flow of stomach qi. Liver depression and qi stagnation are related to emotions, and thus the disease often recurs or worsens due to emotional factors. Stringy pulse indicates liver disease, and thin white tongue coating indicates that the disease is in the early stages, and the evil qi has not yet turned into heat.

[0067] (4) Spleen and stomach damp-heat syndrome

[0068] Symptoms: burning and distending pain in the stomach, noisy feeling, abdominal distension, dry and bitter mouth, thirst without desire to drink, heaviness and fatigue, yellow urine, red tongue, yellow and greasy coating, and slippery and rapid pulse.

[0069] Analysis: Damp-heat accumulates in the spleen and stomach, and Qi flow is sluggish, so there is burning, distending pain in the stomach, and fullness in the abdomen; damp-heat disturbs the inside, and the stomach fails to harmonize and descend, resulting in noisy feeling; damp-heat rises, resulting in dry and bitter mouth; dampness blocks the inside, resulting in thirst but no desire to drink; dampness is heavy and turbid, resulting in heaviness in the body and fatigue in the limbs; damp-heat flows downward, resulting in yellow urine; red tongue, yellow and greasy tongue coating, and slippery and rapid pulse are signs of internal accumulation of damp-heat.

[0070] 5. Western medicine diagnostic criteria

[0071] (1) Gastroscopy

[0072] Changes in mucosal color: The color of the gastric mucosa becomes lighter, appearing light red, grayish yellow, or grayish white in severe cases; it may be diffuse or distributed in localized patchy forms.

[0073] Blood vessel visibility: Submucosal blood vessels are visible. This is because in atrophic gastritis, the gastric mucosa becomes thinner, allowing the submucosal blood vessels to be seen. After the orange-red color of the normal gastric mucosa disappears, blue branch-like blood vessels can be seen under the mucosa.

[0074] The folds become thinner or flatter: The gastric mucosal folds shrink, become smaller or even disappear.

[0075] (2) Pathological examination

[0076] Intrinsic gland atrophy: The number of gastric intrinsic glands (pyloric glands or oxyntic glands) decreases, which can be divided into mild (the number of glands decreases by no more than 1 / 3 of the original glands), moderate (the number of glands decreases by between 1 / 3 and 2 / 3 of the original glands) and severe (the number of glands decreases by more than 2 / 3 of the original glands).

[0077] Intestinal metaplasia: The transformation of gastric mucosal epithelium into small intestinal or large intestinal mucosal epithelial tissue containing goblet cells is a relatively common pathological change. Intestinal metaplasia is divided into complete and incomplete types. Incomplete intestinal metaplasia is more closely related to the occurrence of gastric cancer.

[0078] Pseudopyloric metaplasia: Pyloric metaplasia occurs in the glands of the gastric body or fundus mucosa, and its appearance is often accompanied by atrophy of the gastric mucosa.

[0079] Infiltration of inflammatory cells: Chronic inflammatory cells such as lymphocytes and plasma cells infiltrate the lamina propria of the gastric mucosa.

[0080] 6. Clinical symptoms

[0081] (1) Digestive system symptoms

[0082] Epigastric pain: The pain can be of various natures, such as dull pain, distending pain, stabbing pain or burning pain. The onset and frequency of pain are uncertain, and may be aggravated after eating, on an empty stomach or during mood swings. For example, some patients may experience significantly more epigastric pain after eating spicy or greasy food.

[0083] Gastric distension: Patients feel fullness and discomfort in the epigastric region. After eating a small amount of food, they feel full. In severe cases, they even feel that the epigastric region is bloated and unbearable. This is because the emptying function of the stomach is impaired, and food stays in the stomach for too long, producing gas due to fermentation.

[0084] Belching: Frequent belching, long and slow belching, is caused by the upward flow of gas in the stomach and its discharge from the body through the esophagus. It is usually more obvious after eating or when you are nervous.

[0085] Loss of appetite: The patient has no interest in food and eats less because the lesions in the stomach affect the stomach's function of receiving and digesting food, resulting in slower gastrointestinal motility and reduced secretion of digestive juices.

[0086] Nausea and vomiting: Some patients may experience nausea, which may be accompanied by vomiting in severe cases. Vomitus is usually undigested food or gastric juice in the stomach. When the gastric mucosa is irritated or the stomach emptying disorder is serious, vomiting is likely to occur.

[0087] Constipation or diarrhea: Some patients have dry stools and difficulty in defecation, which is caused by weakened gastrointestinal motility and excessive water absorption. Other patients have diarrhea, unformed stools, and increased frequency, which may be related to gastrointestinal dysfunction and poor digestion and absorption.

[0088] (2) Systemic symptoms

[0089] Weight loss: Due to long-term loss of appetite and insufficient nutritional intake, patients may experience gradual weight loss and body weight loss.

[0090] Fatigue: Patients often feel weak and lack of energy. This is due to nutritional deficiencies, insufficient energy supply to the body, and chronic diseases that consume the body's energy.

[0091] Anemia symptoms (some patients): When chronic atrophic gastritis leads to a decrease in the secretion of intrinsic factor and affects the absorption of vitamin B12, megaloblastic anemia may occur. Patients will show symptoms such as pale complexion, dizziness, palpitations, and shortness of breath.

[0092] Table 1 Clinical use of Chinese herbal medicine mixtures in the treatment of chronic atrophic gastritis

[0093] years 2019 2020 2021 2022 2023 Dosage / bottle 1732 2845 14120 15180 17980

[0094] Table 2 Observation of the efficacy of Chinese medicine mixture for the treatment of chronic atrophic gastritis in 100 cases

[0095] Evaluation effect Evaluation Criteria Number of cases get well Clinical symptoms and signs disappear 78 Significant effect Clinical symptoms improved significantly, with symptom scores reduced by more than 2 / 3 18 efficient Clinical symptoms were alleviated, and the symptom score was reduced by more than 1 / 3 4 invalid There was no improvement or worsening of clinical symptoms, and the symptom score was reduced by less than 1 / 3. 0

[0096] According to the results analysis in Table 2, the clinical symptoms of the patients were significantly improved after taking the medicine. In the treatment group, 78 cases (78%) were cured, 18 cases (18%) were significantly effective, 4 cases (4%) were effective, and 0 cases (0%) were ineffective. The effective rate was 100%, indicating that the Chinese herbal mixture for treating chronic atrophic gastritis has a significant therapeutic effect on chronic atrophic gastritis.

[0097] The beneficial effects of the drug of the present invention for treating chronic atrophic gastritis are further described by the specific experimental examples in Table 3 below:

[0098] Experimental drugs:

[0099] In the prescription of the present invention, Codonopsis pilosula and Polygonatum odoratum are the main drugs. The inventor has found through experiments that heavy use of Codonopsis pilosula and Polygonatum odoratum is helpful to tonify the spleen and nourish the stomach. When the dosage of the two is reduced and the dosage of other Chinese medicines remains unchanged, the effect is significantly reduced; when the dosage of the two is reduced and the dosage of other Chinese medicines (minister drugs, adjuvant drugs, and guiding drugs) in the prescription is increased, the therapeutic effect is still significantly reduced compared with when Codonopsis pilosula and Polygonatum odoratum are the main drugs.

[0100] The composition of each formula in Table 3 is as follows:

[0101] Group 1: Take Codonopsis pilosula 15g, Polygonatum odoratum 15g, Pinellia ternata 12g, Poria 15g, Raw Atractylodes macrocephala 20g, Cyperus rotundus 12g, Panax notoginseng powder 6g, Gleditsia sinensis 30g, Tripterygium wilfordii 15g, Hedyotis diffusa 30g, Raw Licorice root 10g

[0102] Group 2: Take Codonopsis pilosula 10g, Polygonatum odoratum 10g, Pinellia ternata 12g, Poria 15g, Raw Atractylodes macrocephala 20g, Cyperus rotundus 12g, Panax notoginseng powder 6g, Gleditsia sinensis 30g, Tripterygium wilfordii 15g, Hedyotis diffusa 30g, Raw Licorice root 10g

[0103] Group 3: Take Codonopsis pilosula 10g, Polygonatum odoratum 10g, Pinellia ternata 17g, Poria 20g, Raw Atractylodes macrocephala 25g, Cyperus rotundus 17g, Panax notoginseng powder 11g, Gleditsia sinensis 35g, Tripterygium wilfordii 20g, Hedyotis diffusa 35g, Raw Licorice root 15g

[0104] Table 3: Experimental example of drug dosage screening (%)

[0105] Grouping get well Significant effect Improvement invalid Total effective 1 group 16(80％) 3(15％) 1(5％) 0(0％) 19(95％) 2 groups 11(55％) 4(20％) 5(25％) 0(0％) 15(75％) 3 groups 8(40％) 5(25％) 6(30％) 1(5％) 13(65％)

[0106] It can be found in Table 3 that the drugs in groups 1-3 of the implementation cases were respectively used for experiments. The experiments show that the best therapeutic effect can be achieved by using Codonopsis pilosula and Polygonatum odoratum as the main drugs in the prescription of the present invention. When the dosage of the two drugs is reduced as in Group 2 or the dosage of the two drugs is reduced as in Group 3 while the dosage of other drugs is increased, the total effective rate of treatment is significantly reduced.

[0107] Typical treatment cases:

[0108] Case 1, Wang, female, 54 years old, the main reason for "gastric distension and discomfort for 2 months" was to see a doctor. The current symptoms: gastric distension and discomfort, paroxysmal, acid reflux and heartburn, belching and hiccups, dry mouth and bitter taste, fatigue and tiredness, accompanied by lower abdominal distension, poor appetite, poor eyesight, and normal urination and defecation. Look, smell, ask, and cut: clear mind, poor spirit, normal expression, moderate body shape, sallow complexion, normal demeanor, clear speech, normal voice and breath, dark red tongue, white greasy fur, and fine and astringent pulse. The present invention is used to treat chronic atrophic gastritis. After three days, the above symptoms are significantly relieved, the spirit is good, the complexion is flushed, and after continuing to use the medicine for 2 weeks, the patient's gastric distension and discomfort disappear, and the appetite and sleep are good.

[0109] Case 2, He Moumou, male, 74 years old, was diagnosed with "distension and discomfort in the epigastric region accompanied by nausea and retching for 3 months". Current symptoms: distension and discomfort in the epigastric region, occasional dull pain, nausea and retching, belching and hiccups, dry mouth and bitter taste, fatigue and lethargy, poor appetite, poor eyesight, and normal urination and defecation. Look, smell, ask, and cut: clear mind, poor spirit, normal expression, moderate body shape, sallow complexion, normal demeanor, clear speech, normal voice and breath, dark red tongue, white fur, and fine and astringent pulse. The present invention is used to treat chronic atrophic gastritis. After five days, the above symptoms are significantly relieved, the spirit is good, the complexion is flushed, and after continuing to use the medicine for 3 weeks, the patient's distension and discomfort in the epigastric region disappears, and the appetite and sleep are good.

[0110] Case 3, Wang Mo, male, 86 years old, was diagnosed with "distension and discomfort in the epigastric region accompanied by hiccups for 1 month". Current symptoms: distension and discomfort in the epigastric region, occasional dull pain, belching and hiccups, dry mouth, fatigue and lassitude, accompanied by palpitations, chest tightness and shortness of breath, poor appetite, poor eyesight, and normal urination and defecation. Look, smell, ask, and palpate: clear mind, poor spirit, normal expression, moderate body shape, sallow complexion, normal demeanor, clear speech, normal voice and breath, tooth marks on the tongue, dark red tongue, white fur, and deep and astringent pulse. The present invention is used to treat chronic atrophic gastritis. After six days, the above symptoms are significantly relieved, the spirit is good, the complexion is flushed, and after continuing to use the medicine for 3 weeks, the patient's distension and discomfort in the epigastric region disappears, and the appetite and sleep are good.

[0111] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A Chinese medicine composition for treating chronic atrophic gastritis, characterized in that: The invention is composed of the following raw materials in parts by weight: 10-20 parts of Codonopsis pilosula, 10-20 parts of Polygonatum odoratum, 7-17 parts of Pinellia ternata, 10-20 parts of Poria cocos, 15-25 parts of raw Atractylodes macrocephala, 7-17 parts of Cyperus rotundus, 1-11 parts of Panax notoginseng powder, 25-35 parts of Gleditsia sinensis spines, 10-20 parts of Psoralea corylifolia, 25-35 parts of Hedyotis diffusa and 5-15 parts of raw liquorice.

2. A Chinese medicine composition for treating chronic atrophic gastritis according to claim 1, characterized in that: The invention is composed of the following raw materials in parts by weight: 15 parts of Codonopsis pilosula, 15 parts of Polygonatum odoratum, 12 parts of Pinellia ternata, 15 parts of Poria cocos, 20 parts of raw Atractylodes macrocephala, 12 parts of Cyperus rotundus, 6 parts of Panax notoginseng powder, 30 parts of Gleditsia sinensis spines, 15 parts of Psoralea corylifolia, 30 parts of Hedyotis diffusa and 10 parts of raw liquorice.

3. A Chinese medicine composition for treating chronic atrophic gastritis according to claim 1, characterized in that: The invention is composed of the following raw materials in parts by weight: 10 parts of Codonopsis pilosula, 10 parts of Polygonatum odoratum, 12 parts of Pinellia ternata, 15 parts of Poria cocos, 20 parts of raw Atractylodes macrocephala, 12 parts of Cyperus rotundus, 6 parts of Panax notoginseng powder, 30 parts of Gleditsia sinensis spines, 15 parts of Psoralea corylifolia, 30 parts of Hedyotis diffusa and 10 parts of raw liquorice.

4. A Chinese medicine composition for treating chronic atrophic gastritis according to claim 1, characterized in that: The invention is composed of the following raw materials in parts by weight: 10 parts of Codonopsis pilosula, 10 parts of Polygonatum odoratum, 17 parts of Pinellia ternata, 20 parts of Poria cocos, 25 parts of raw Atractylodes macrocephala, 17 parts of Cyperus rotundus, 11 parts of Panax notoginseng powder, 35 parts of Gleditsia sinensis spines, 20 parts of Psoralea corylifolia, 35 parts of Hedyotis diffusa and 15 parts of raw liquorice.

5. A Chinese medicine composition for treating chronic atrophic gastritis according to claim 1, characterized in that: The invention is composed of the following raw materials in parts by weight: 20 parts of Codonopsis pilosula, 20 parts of Polygonatum odoratum, 7 parts of Pinellia ternata, 10 parts of Poria cocos, 15 parts of raw Atractylodes macrocephala, 7 parts of Cyperus rotundus, 1 part of Panax notoginseng powder, 25 parts of Gleditsia sinensis spines, 10 parts of Psoralea corylifolia, 25 parts of Hedyotis diffusa and 5 parts of raw liquorice.

6. A method for preparing a Chinese medicine composition for treating chronic atrophic gastritis according to any one of claims 1 to 5, characterized in that: The following steps are involved: (1) Codonopsis pilosula, Polygonatum odoratum, Pinellia tuber, Poria cocos, raw Atractylodes macrocephala, Cyperus rotundus, notoginseng powder, Gleditsia sinensis, Psoralea corylifolia, Hedyotis diffusa and raw Licorice root are mixed according to the weight proportions, and weighed for later use; (2) Take Codonopsis pilosula, Polygonatum odoratum, Pinellia ternata, Poria cocos, Atractylodes macrocephala, Cyperus rotundus, Gleditsia sinensis, Psoralea corylifolia, Hedyotis diffusa and Licorice root, add 8-12 times the amount of water, soak for 0.5-1.5 hours, and perform the first heating and decoction for 1.5 hours; (3) adding Panax notoginseng powder to the mixture, filtering, and collecting the first extract and the medicinal residue; (4) adding 6-10 times the amount of water to the medicinal residue, heating and boiling for a second time for 1 hour, filtering, and collecting a second extract; (5) combining and mixing the first extract and the second extract, heating and concentrating the mixture to obtain a concentrated solution; (6) The concentrated liquid is sterilized in a water bath to obtain the finished product.

7. The method for preparing a Chinese medicine mixture for treating chronic atrophic gastritis according to claim 6, wherein in step (3), the Panax notoginseng powder is added 5-10 minutes before the end of the first heating and decoction.

8. The method for preparing a Chinese medicine mixture for treating chronic atrophic gastritis according to claim 6, wherein in step (3), the notoginseng powder is added after the first heating and decocting is completed.

9. The method for preparing a Chinese medicine mixture for treating chronic atrophic gastritis according to claim 6, wherein after step (5), the following operation can be performed: sampling the concentrated solution, and after the sampled concentrated solution is inspected and found to be qualified, the concentrated solution is filled by an automatic filling machine and sealed and packaged.

10. The method for preparing a Chinese medicine mixture for treating chronic atrophic gastritis according to claim 9, wherein the qualified inspection standard is a pH value of 4.0-6.0 and a concentrated relative density of 1.01-1.05.