Traditional Chinese medicine ironing hot compress bag preparation for treating urination disorder as well as preparation method and application of traditional Chinese medicine ironing hot compress bag preparation

Abstract

The invention discloses a traditional Chinese medicine ironing hot compress bag preparation for treating urination disorder as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. According to the invention, traditional Chinese medicines capable of promoting blood circulation, regulating qi, soothing liver and treating stranguria are combined with aromatic transdermal traditional Chinese medicines to prepare a'red tiger formula 'hot compress bag preparation, and the raw materials comprise pyrrosia lingua, sargentgloryvine stem, polygonum cuspidatum, ligusticum wallichii, liquidambar formosana hance, fennel and rhizoma zingiberis. The urination disorder of a patient is clinically treated through traditional Chinese medicine ironing, and the result shows that the traditional Chinese medicine ironing hot compress bag provided by the invention has few side effects and is clinically safe and effective; the traditional Chinese medicine composition is used for treating urination disorder caused by benign prostatic hyperplasia, and can reduce IPSS points, improve urination symptoms and relieve traditional Chinese medicine symptoms; the traditional Chinese medicine composition is combined with modern medicines to treat urination disorder caused by chronic abacterial prostatitis, and compared with pure use of the modern medicines, urination symptoms such as pain, frequent urination and urgent urination of patients can be more obviously relieved, and the life quality of the patients is improved.

Description

Technical Field

[0001] The invention relates to the field of traditional Chinese medicine, and in particular to a traditional Chinese medicine ironing hot package preparation for treating urination disorders, and a preparation method and application thereof. Background Art

[0002] Urinary retention refers to the obstruction of urine discharge and retention in the bladder. It is a clinical syndrome caused by many diseases, trauma, surgery or anesthesia. It is divided into acute urinary retention and chronic urinary retention according to the speed of occurrence. It is mainly manifested as dysuria, poor dripping, unbearable pain or blockage, which greatly affects the quality of life of patients. Urination is a positive feedback reflex physiological activity controlled by the higher nerve center. When the urge to urinate occurs, the higher nerve center can control the urination reflex center of the spinal cord to undergo alienation, promote the contraction of the detrusor muscle and the relaxation of the internal urethral sphincter, so as to urinate smoothly. If there is a problem in any of these links, urine discharge will be obstructed and urine retention will occur.

[0003] According to its etiology, it can be roughly divided into two categories: mechanical obstruction and dynamic obstruction. Mechanical obstruction includes: 1. Extraurethral mechanical compression: prostate diseases such as prostatic hyperplasia, acute prostatitis or prostatic abscess, prostate tumor, etc.; pelvic fracture compressing the urethra; rectal tumor, fecal mass in the rectum; retroverted uterus of pregnancy, colposusia with hymen occlusion, cervical cancer, uterine fibroids, etc.; phimosis, foreskin incarceration, and abnormal erection of the penis. 2. Mechanical obstruction in the urethra: urethral injury and urethral stenosis. Urethral stenosis causes acute urinary retention, which is often induced by local edema and pain after urethral dilatation; urethritis, urethral tumor; congenital hyperplasia of spermatophore, urethral valve, bladder neck contracture; urethral stones, urethral foreign bodies. 3. Intra-bladder lesions: bladder trigone, bladder neck tumor, bladder stones, foreign bodies in the bladder, large amounts of blood clots in the bladder, etc. block the bladder neck and urethra. Dynamic obstruction includes: 1. Neurogenic urinary retention: upper motor neuron lesions (spinal cord injury, tumors and multiple sclerosis, etc.); lower motor neuron lesions (various spinal cord compression such as tumors, epidural abscesses, hematomas, central disc herniation, etc.); lesions affecting the motor and sensory nerves of the bladder (common in diabetes, herpes simplex, extensive pelvic surgery, etc.); bladder overdistension after surgical anesthesia (sphincter spasms caused by perineal surgery, pain, inflammation, etc. can all cause urinary retention). 2. Drug-induced urinary retention: central nervous system inhibitors; anticholinergic drugs such as atropine; certain hypertension drugs, antiarrhythmic drugs, calcium channel blockers; antihistamines; certain antidepressants, etc. 3. Others: hypokalemia caused by various reasons such as aldosteronism, diarrhea, long-term use of diuretics; high fever, comatose patients; those who are not used to urinating in bed; hysteria, etc. Generally speaking, the most common urinary retention in clinical practice comes from postoperative conditions, neurogenic bladder, and benign prostatic hyperplasia in middle-aged and elderly men.

[0004] Urinary dysfunction / urinary retention belongs to the category of "stranguria and retention" in traditional Chinese medicine. "Yi Zong Must Read" points out that there is a difference between "stranguria" and "retention". "Stranguria" is characterized by short and poor urination, and the disease progresses slowly; "retention" is characterized by blocked urination, and the disease progresses urgently. The two belong to different degrees of "difficult urination", so they are often collectively referred to as stranguria and retention. "Nei Jing" was the first to elaborate on the cause, pathogenesis, and location of "stranguria and retention". For example, "Ling Shu·Four Seasons Qi" pointed out: "Lower abdominal swelling and pain, unable to urinate, the evil is in the triple burner"; "Su Wen·Biao Ben Bing Chuan Lun" pointed out: "Bladder disease, urinary retention". It can be seen that the location of stranguria and retention is mainly in the bladder and triple burner.

[0005] The causes of urinary dysfunction / urinary retention are complex, and there are many ways to prevent and treat urinary retention. Modern medicine mainly includes: causal treatment and symptomatic treatment. If the cause is clear and the conditions are available to relieve the obstruction in time, the cause should be relieved immediately and urination should be resumed. Endoscopic treatment is the first choice for urinary retention caused by urethral stenosis, lower urinary tract stones, bladder tumors, and prostatic hyperplasia. Symptomatic treatment is the first choice for urine drainage (indwelling catheterization, suprapubic bladder puncture and aspiration, cystostomy). In addition, psychological counseling, control of fluid input, drug therapy, induced urination and other methods are often used when urine drainage is unsuccessful. Drug use Neostigmine is an acetylcholinesterase inhibitor that mainly acts on the M cholinergic receptors on the bladder detrusor muscle to increase the tension of the bladder detrusor muscle to resume urination. However, neostigmine cannot be used for a long time or in excessive amounts, otherwise it will cause adverse reactions of M receptor excitation, such as abdominal pain, nausea, coma, etc. In Western medicine, indwelling catheterization is currently an important method for treating postoperative dysuria, but catheter implantation is an invasive operation that can easily damage the urethral mucosa and may bring in external pathogens, causing urinary tract infection and bacteriuria. The incidence of bacteriuria is positively correlated with the duration of indwelling catheterization. On the 10th day of indwelling catheterization, the positive rate of bacteriuria can reach 100%. Traditional Chinese medicine has been widely promoted and applied in the treatment of urinary retention. It is not only effective, but also simple, safe, and has no toxic side effects, and has certain advantages. Oral Chinese medicine, hot compress of Chinese medicine, acupuncture therapy, acupoint massage, ear acupoint pressing, etc. are often used. The pathogenesis of stranguria is mainly due to bladder qi dysfunction. According to the principle of "treating the viscera with unblocking as the purpose", stranguria should be treated with unblocking as the main method. Zhang Zhongjing made great contributions to the treatment of stranguria in Treatise on Febrile Diseases and Synopsis of Golden Plaques, and recorded a large number of effective prescriptions, such as Wuling Powder, Zhuling Decoction, Zhenwu Decoction, and Trichosanthes and Qumai Pills. Acupuncture treatment of urinary retention was first proposed in Huangdi Neijing. For example, Lingshu Xieqi Zangfu Disease Form proposed that patients with bladder lesions, lower abdominal swelling and pain, and inability to urinate can be treated with the bladder meridian's He point Weizhong acupoint. Studies have shown that acupuncture can dredge meridians, relieve patients' pain, improve pelvic nerve function, contract the bladder detrusor muscle, relieve bladder neck and urethral sphincter spasms, and promote urination. The effect is better when combined with moxibustion. Therefore, it is urgent to provide an external prescription based on traditional Chinese medicine theory that can effectively treat urinary disorders. Summary of the invention

[0006] The purpose of the present invention is to provide a Chinese medicine ironing hot-iron bag preparation for treating urinary disorders and its preparation method and application, so as to solve the problems existing in the above-mentioned prior art. The present invention uses Chinese medicine that can promote blood circulation and regulate qi, soothe the liver and relieve stranguria combined with aromatic and transdermal Chinese medicine to prepare the "Honghu Fang" hot-iron bag preparation. Compared with the use of modern drugs alone, it can more significantly relieve the urination symptoms such as pain, frequent urination, and urgency of urination in patients with urinary disorders, and improve their quality of life.

[0007] To achieve the above object, the present invention provides the following solutions:

[0008] The invention provides a pharmaceutical composition for treating urination disorder, comprising the following components: pyrrosia, safflower, polygonum cuspidatum, chuanxiong, liquidambar formosana, fennel and dried ginger.

[0009] Preferably, the following components are included by weight:

[0010] 15 parts of Pyrola, 30 parts of Sargentodoxae, 15 parts of Polygonum cuspidatum, 15 parts of Rhizoma Chuanxiong, 15 parts of Fructus Liquidambar, 12 parts of Fennel and 12 parts of Drynariae Zingiberis.

[0011] Among them, Sargentodoxae has detoxifying and promoting blood circulation, Polygonum cuspidatum has diuretic and blood stasis-relieving effects and is the main medicine, while Ligusticum chuanxiong has the effects of regulating qi and promoting blood circulation, Pyrola has the effects of promoting diuresis and relieving stranguria, and dispelling wind and unblocking collaterals are the auxiliary medicines. In addition, fennel is used to dispel cold and relieve pain, and aromatic drugs can penetrate the skin and enter the collaterals, while dried ginger warms and promotes yang qi, restores yang, dredges the meridians, and helps guide the drugs into the acupuncture points. All the medicines work together to promote blood circulation and regulate qi, soothe the liver and relieve stranguria, and clear the urinary orifices.

[0012] Functions and indications of each raw material medicine in the Chinese medicine ironing hot pack preparation provided by the present invention:

[0013] The nature of the sedge vine is bitter and flat. It mainly enters the liver meridian and the large intestine meridian and has the effects of clearing away heat and detoxification, promoting blood circulation, dispelling wind and relieving pain. Cnidium monnieri was first recorded in the "Compendium of Materia Medica", which mentioned "attacking blood and removing blood clots". The "Chinese Materia Medica Records" said: it dispels wind and dredges the meridians, and is diuretic and insecticidal. It can treat intestinal carbuncle, rheumatic pain, leprosy, gonorrhea: abdominal pain caused by roundworms. It can treat acute and chronic appendicitis, rheumatic pain, dysentery, hematuria, irregular menstruation, malnutrition, worm pain, and injuries from falls. It can attack blood and treat blood clots. Its modern pharmacological research shows that its water extract can inhibit the swelling of the mouse ear caused by xylene, reduce the swelling degree and swelling rate, and has an anti-inflammatory effect; it prolongs the pain threshold latency of the acetic acid-induced pain model mice and reduces the number of twisting, inhibits the proliferation of mouse granulation tissue, and has an analgesic effect; the alcohol extract of Sargassum ulmoides has the same anti-inflammatory and analgesic effects as Yunnan Baiyao tincture, which provides a theoretical basis for the AESC folk use of wine soaking method for dispelling wind and relieving pain, dysmenorrhea, and swelling and pain caused by falls. The alcohol extract of Sargassum ulmoides can significantly reduce the swelling of the mouse ear caused by xylene; compared with the blank group and before administration, it can significantly increase the pain threshold of mice.

[0014] Polygonum cuspidatum is slightly cold in nature and enters the liver, gallbladder and lung meridians. It has the functions of removing dampness and jaundice, clearing away heat and detoxifying, dispersing blood stasis and relieving pain, relieving cough and reducing phlegm. It is used to treat damp-heat jaundice, stranguria, leucorrhea, rheumatic pain, carbuncle, burns, amenorrhea, masses, traumatic injuries, lung heat cough, etc. Modern pharmacological studies have shown that Polygonum cuspidatum has anti-inflammatory, antioxidant, antiviral, antibacterial, anticancer, liver protection, cardiovascular protection, and immunomodulatory effects, and can be used to treat diabetes, gout, cancer, respiratory and cardiovascular diseases. The acute gouty arthritis model was induced by injecting sodium urate crystals (MSU) into the ankle joints of mice. The use of Polygonum cuspidatum ethanol extract significantly reduced the swelling of the ankle joints of mice, the levels of inflammatory factors IL-1β, IL-6 and TNF-α in the synovial membrane, and reduced the protein and mRNA expression of the NLR family pyrin domain protein 3 (NLRP3) / apoptosis-associated speck-like protein (ASC) / cysteine ​​aspartate protein hydrolase-1 (Caspase-1) axis. Among them, stilbenes and anthraquinones may be the main anti-gouty arthritis components in Polygonum cuspidatum extract.

[0015] Chuanxiong is warm in nature, pungent and slightly sweet in taste, and enters the liver, gallbladder, and pericardium meridians. The Chinese Materia Medica records that it has the effects of promoting qi and relieving depression, removing wind and dampness, and promoting blood circulation and relieving pain. As the main active ingredient of Chuanxiong, Chuanxiong volatile oil can play an antioxidant, anti-inflammatory, neuroprotective, and vascular homeostasis role by regulating multiple related pathways and multi-target effects inside and outside the cell in a variety of oxidative damage, nerve damage, and inflammation models. Chuanxiong volatile oil has a repair effect on SY5Y cells with oxidative damage within a certain range, and its mechanism of action may be related to scavenging ROS, reducing DNA oxidative damage, and inhibiting cell apoptosis. Studies have found that Chuanxiong volatile oil can promote drug transdermal absorption and relieve pain. Chuanxiong volatile oil can promote drug transdermal absorption by interfering with the lipid arrangement of the skin stratum corneum and increasing lipid fluidity. In clinical studies on acute knee synovitis, the combination of Chuanxiong volatile oil and frankincense volatile oil can relieve joint swelling, increase the range of motion of the knee joint, and greatly reduce the pain of patients during treatment.

[0016] Pyrrosia is sweet and bitter in taste, slightly cold in nature, and has the effects of clearing the lungs and relieving cough, promoting diuresis and relieving stranguria, cooling blood and stopping bleeding. The extract has antioxidant, antibacterial, anti-inflammatory, diuretic, wound healing, anti-kidney stone, and anti-diabetic effects, among which flavonoids and phenols are the main active ingredients. Studies have shown that flavonoid compounds in Pyrrosia have inhibitory effects on various pathogens such as Staphylococcus aureus, Micrococcus luteus, Escherichia coli, and Shigella freundii. The researchers made a homemade experimental Pyrrosia ointment, and found that it can shorten the wound healing time and increase the wound healing rate in the rat trauma model, and the scar area after treatment in the ointment group is significantly smaller than that in the natural recovery group and the positive control Jingwanhong treatment group. During the treatment of infected wounds, the results of HE pathological sections and the changes in cytokines such as TNF-α, IL-6, and FGF-2 in serum showed that the ointment can antagonize Staphylococcus aureus infection, reduce the infiltration of inflammatory cells such as neutrophils, promote the growth of granulation tissue and epidermal tissue, the formation of the dermis and the regeneration of hair follicles, and restore skin elasticity.

[0017] Rhizoma Lulutong is mild in nature and bitter in taste. It belongs to the liver and kidney meridians. It dispels wind and dredges the collaterals, promotes diuresis and removes dampness. It is mainly used to treat limb pain, cramps in the hands and feet, stomachache, edema, distension, amenorrhea, lactation, carbuncle, hemorrhoid fistula, scabies, and eczema. Rhizoma Lulutong has anti-inflammatory, swelling-reducing and analgesic effects. Its main ingredients are betulinic acid (also known as Rhizoma Lulutong acid) and gallic acid. It exerts its anti-inflammatory effect mainly by reducing capillary permeability, inhibiting the secretion of inflammatory mediators, and participating in the NF-KB signaling pathway.

[0018] Fennel is warm in nature and pungent in taste. It belongs to the liver meridian, kidney meridian, spleen meridian, and stomach meridian; it dispels cold and relieves pain, regulates qi and harmonizes the stomach. It is used for abdominal pain caused by cold hernia, testicular prolapse, dysmenorrhea, cold pain in the lower abdomen, abdominal distension and pain, poor appetite, vomiting and diarrhea, and testicular hydrocele. Salt fennel warms the kidney and dispels cold and relieves pain. It is used for abdominal pain caused by cold hernia, testicular prolapse, and abdominal pain caused by cold menstruation. Experiments were conducted on healthy SD uncles, and the results showed that fennel has a significant diuretic and sleep-inducing effect on uncles, and can also reduce ALD and NOS in uncles with cirrhosis. Fennel oil passes through the skin from the surface to the inside, runs along the meridians, reaches the internal organs, and acts on the bladder, which can relieve the spasm caused by the excitement of the bladder smooth muscle (detrusor muscle) and the internal urethral sphincter, and restore the balance between the excitement and inhibition of the urination center.

[0019] Dried ginger is hot and pungent in taste. It enters the spleen, kidney, stomach, heart and lung meridians; it warms the middle and expels cold, restores yang and dredges the meridians. It can treat cold pain in the heart and abdomen, vomiting and diarrhea, cold limbs and weak pulse, asthma and cough due to cold, wind-cold and dampness, vomiting, epistaxis and bleeding due to yang deficiency. The ether extract, water extract and alcohol extract of dried ginger all have obvious anti-inflammatory effects; the analgesic and anti-inflammatory components of dried ginger are mainly fat-soluble gingerol compounds and sesquiterpene components zingiberene, among which 6-gingerol can inhibit the expression of phosphodiesterase 4 (PDE4) in inflammatory cells and play an anti-inflammatory role; the spicy components such as volatile oil contained in dried ginger can accelerate local microcirculation, thereby protecting the wound surface and promoting healing; the function of dried ginger volatile oil to accelerate local blood circulation can accelerate the blood flow metabolism in the abdomen and bladder, and more easily promote the production of urination.

[0020] The present invention also provides an application of the pharmaceutical composition in preparing a medicine for treating urination disorders.

[0021] Preferably, the urination disorder is a urination disorder caused by a prostate disease.

[0022] Preferably, the prostate disease is benign prostatic hyperplasia or chronic nonbacterial prostatitis.

[0023] Preferably, the urination disorder is urination disorder caused by surgical treatment.

[0024] The present invention also provides a medicine for treating urination disorders, wherein the only effective ingredient of the medicine is the medicine composition.

[0025] Preferably, a pharmaceutically acceptable excipient is also included.

[0026] Preferably, the dosage form of the drug is a traditional Chinese medicine ironing hot pack preparation.

[0027] The present invention also provides a method for preparing a traditional Chinese medicine ironing hot package preparation for treating urination disorders, comprising:

[0028] Weigh the above-mentioned pharmaceutical composition according to weight, grind them into coarsest powder respectively, mix them evenly, and obtain mixed powder;

[0029] The Chinese medicine ironing hot bag preparation is obtained by bagging.

[0030] Preferably, the bagging is to pack the mixed powder into a non-woven bag according to a specification of 60 g / bag.

[0031] The present invention discloses the following technical effects:

[0032] The present invention uses Chinese medicines that can activate blood circulation and regulate qi, soothe the liver and relieve stranguria, and combine with aromatic transdermal Chinese medicine to prepare the "Honghu Fang" hot-an-bao preparation, and the raw materials are composed of pyrrosia, sedum ulmoides, knotweed, chuanxiong, fennel, fennel and dried ginger. Clinically, patients with urinary disorders are treated by Chinese medicine ironing. The results show that the Chinese medicine ironing hot-an-bao provided by the present invention has few side effects and is clinically safe and effective; it is used to treat urinary disorders caused by benign prostatic hyperplasia, can reduce IPSS scores, improve urination symptoms, and relieve Chinese medicine symptoms; combined with modern drugs to treat urinary disorders caused by chronic non-bacterial prostatitis, it can more significantly relieve patients' pain, frequent urination, urgency and other urination symptoms compared to the use of modern drugs alone, and improve their quality of life. DETAILED DESCRIPTION

[0033] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as limiting the present invention, but should be understood as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0034] It should be understood that the terms described in the present invention are only for describing a particular embodiment and are not intended to limit the present invention. In addition, for the numerical range in the present invention, it should be understood that each intermediate value between the upper and lower limits of the scope is also specifically disclosed. The intermediate value in any stated value or stated range, and each smaller range between any other stated value or intermediate value in the described range is also included in the present invention. The upper and lower limits of these smaller ranges can be independently included or excluded in the scope.

[0035] Unless otherwise indicated, all technical and scientific terms used herein have the same meanings as those generally understood by those skilled in the art. Although the present invention describes only preferred methods and materials, any methods and materials similar or equivalent to those described herein may also be used in the implementation or testing of the present invention. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials associated with the documents. In the event of a conflict with any incorporated document, the content of this specification shall prevail.

[0036] It will be apparent to those skilled in the art that various modifications and variations may be made to the specific embodiments of the present invention description without departing from the scope or spirit of the present invention. Other embodiments derived from the present invention description will be apparent to those skilled in the art. The present invention description and examples are exemplary only.

[0037] The words “include,” “including,” “have,” “contain,” etc. used in this document are open-ended terms, meaning including but not limited to.

[0038] The causes of urination disorders / urinary retention are complex, and there are many methods of prevention and treatment. Modern medicine mainly includes: causal treatment and symptomatic treatment. If the cause is clear and the conditions are available to relieve the obstruction in time, the cause should be relieved immediately and urination should be resumed. Urinary drainage is the first choice for urinary retention caused by urethral stenosis, lower urinary tract stones, bladder tumors, and prostatic hyperplasia. Symptomatic treatment is the first choice for urine drainage (indwelling catheterization, suprapubic bladder puncture and aspiration, cystostomy). In addition, psychological counseling, control of fluid input, drug therapy, induced urination and other methods are often used when urine drainage is unsuccessful. Drug use Neostigmine is an acetylcholinesterase inhibitor that mainly acts on the M cholinergic receptors on the bladder detrusor muscle to increase the tension of the bladder detrusor muscle to resume urination. However, neostigmine cannot be used for a long time or in excessive amounts, otherwise it will cause adverse reactions of M receptor excitation, such as abdominal pain, nausea, coma, etc. In Western medicine, indwelling catheterization is currently an important method for treating postoperative dysuria, but catheter implantation is an invasive operation that can easily damage the urethral mucosa and may bring in external pathogens, causing urinary tract infection and bacteriuria. The incidence of bacteriuria is positively correlated with the duration of indwelling catheterization. On the 10th day of indwelling catheterization, the positive rate of bacteriuria can reach 100%. Traditional Chinese medicine has been widely promoted and applied in the treatment of urinary dysfunction / urinary retention. It is not only effective, but also simple, safe, and has no toxic side effects, and has certain advantages. Oral Chinese medicine, hot compress of Chinese medicine, acupuncture therapy, acupoint massage, ear acupoint pressing, etc. are often used. The pathogenesis of stranguria is mainly due to bladder qi dysfunction. According to the principle of "treating the viscera with unblocking as the purpose", stranguria should be treated with unblocking as the main method. Zhang Zhongjing made great contributions to the treatment of stranguria in Treatise on Febrile Diseases and Synopsis of Golden Plaques, and recorded a large number of effective prescriptions, such as Wuling Powder, Zhuling Decoction, Zhenwu Decoction, and Trichosanthes and Qumai Pills. Acupuncture treatment of urinary retention was first proposed in Huangdi Neijing. For example, Lingshu: Evil Qi and Organ Disease Forms proposed that patients with bladder lesions, lower abdominal swelling and pain, and inability to urinate can be treated with Weizhong acupoint, a He point on the bladder meridian. Studies have shown that acupuncture can dredge meridians, relieve pain in patients, improve pelvic nerve function, contract the bladder detrusor, relieve spasms of the bladder neck and urethral sphincter, and promote urination. The effect is better when combined with moxibustion. Chinese medicine hot pack is a very distinctive external treatment method in traditional Chinese medicine, also known as Chinese medicine hot ironing method. Its origin can be traced back to the pre-Qin period, and it has a long history. The "ironing" method recorded in the "Inner Canon" refers to the hot compress method. The efficacy of Chinese medicine hot pack depends on the heat and the Chinese medicine in the pack. It is often divided into two ways: dry and wet hot compress. For dry hot compress, the Chinese medicine is placed in a bag, heated in a microwave oven, and then wrapped with a towel for external application, such as moxa salt pack; for wet hot compress, the Chinese medicine is steamed and then wrapped with a single sheet for external application, such as Chinese medicine stamping. The hot pack selected by the present invention is dry hot compress, which combines the advantages of Chinese medicine hot compress and acupoint stimulation. After the Chinese medicine hot pack is heated, the hot compress opens the skin texture, and the hot steam is absorbed through the skin, and is conducted through the acupoints and meridians to reach the lesion directly, relieving the spasm of the bladder sphincter, and making the qi and blood flow, thereby achieving the purpose of normal urination.

[0039] External treatment in traditional Chinese medicine has a long history and has its unique advantages. As early as in the Neijing, the emphasis on external treatment was reflected, and the view of "internal treatment for internal diseases and external treatment for external diseases" was proposed. As a heat therapy, the Chinese medicine hot package uses its warm nature to volatilize the medicinal properties and act on the affected area, or directly reach the diseased area through relevant meridians and acupoints. After the affected area and acupoints are heated, the capillaries expand and the blood circulation accelerates, which promotes the efficient penetration of Chinese medicine, improves the absorption and utilization rate of drugs, and the skin penetration can avoid gastrointestinal irritation and "first-pass effect of the liver" caused by oral drugs, thereby playing the role of relaxing muscles and activating collaterals, promoting qi and blood circulation, and calming wind and unblocking collaterals, achieving the effect of external treatment of internal diseases. In recent years, hot package and clinical treatment programs combined with other therapies have been widely used in various aspects, such as postoperative recovery, dredging collaterals and relieving pain, promoting qi and removing dampness, and many other applications covering internal and external medicine, women and children. Compared with traditional oral Chinese medicine, especially for patients who are weak or unable to take Chinese medicine orally, it has the advantages of being simple, cheap, effective, low-toxic and efficient. The Chinese medicine hot yanbao has a wide range of therapeutic effects. If combined with other therapies such as acupuncture, acupoint massage, and oral Chinese medicine, it can solve the patient's curative effect better. A large number of clinical studies have shown that hot yanbao has a definite effect on the treatment of postoperative urinary retention. Su Yanqin used Evodia rutaecarpa and crude salt as raw materials and heated them to make hot yanbao. The acupoints Shenque, Qihai and Zhongji were repeatedly ironed to promote urination in patients with urinary retention after hemorrhoid surgery. After the treatment, it was found that the total effective rate was as high as 97.5%, and it had a certain effect on relieving pain, and the incidence of adverse reactions was low. The present invention uses Chinese medicine hot yanbao to treat various urination disorders, which is relatively simple to operate, is only for external use, and has basically no side effects. It is a method for the treatment of traditional Chinese medicine external treatment characteristics.

[0040] The coarsest powder described in the present invention is consistent with the definition of coarsest powder in the Chinese Pharmacopoeia, Part II, General Rules, which refers to powder that can pass through a No. 1 sieve but is mixed with no more than 20% of powder that can pass through a No. 3 sieve.

[0041] Among them, the inner diameter of the mesh of No. 1 sieve is 2000μm±70μm, and the inner diameter of the mesh of No. 3 sieve is 355μm±13μm.

[0042] Example 1

[0043] According to weight, weigh 15 parts of Pyrola, 30 parts of Sargentodoxae, 15 parts of Polygonum cuspidatum, 15 parts of Ligusticum chuanxiong, 15 parts of Fructus Smilacis Glabrae, 12 parts of Fennel and 12 parts of Dried Ginger, grind them into the coarsest powder respectively, mix them well, put them into non-woven bags at 60 g per bag, and prepare the Chinese medicine ironing hot pack preparation for later use.

[0044] Comparative Example 1

[0045] The only difference from Example 1 is that the weight parts of the various drugs are: 15 parts of Pyrrosia, 15 parts of Sargentodoxae, 15 parts of Polygonum cuspidatum, 15 parts of Ligusticum chuanxiong, 15 parts of Fructus Lycopodiellae, 15 parts of Fructus Lycopodiellae, 15 parts of Fennel and 15 parts of Dry Ginger.

[0046] Example 2

[0047] The Chinese medicine ironing hot package preparation provided by the present invention was administered to patients with urination disorders caused by benign prostatic hyperplasia, and the changes in symptom scores and urination indicators were evaluated.

[0048] 1. Case selection

[0049] 1.1 Diagnostic criteria

[0050] Western medicine diagnostic standards: formulated with reference to the standards recommended by the International Scientific Committee of the International Advisory Committee on Benign Prostatic Hyperplasia and the "Guidelines for the Diagnosis and Treatment of Urological Diseases in China (2014 Edition)".

[0051] ①Symptoms: dysuria, waiting to urinate, weak and thin urine, time-consuming and laborious, interrupted urine flow, frequent urination, frequent urination at night, and even urinary retention or incontinence; ②Rectal digital examination: enlargement of both lobes of the prostate, shallow or disappearance of the central groove, smooth surface, no nodules, tough texture, no tenderness, moderate anal sphincter tension, no blood staining during digital examination; ③B-ultrasound examination: transrectal prostate ultrasound measurement, volume>20mL (calculation formula is 0.52×anteroposterior diameter×lateral diameter×upper and lower diameter); ④Uroflowmetry: maximum urine flow rate Qmax<15mL / s, urine volume>150mL; ⑤Residual urine volume: B-ultrasound examination, determine whether there is residual urine in the bladder, and the residual urine volume in the bladder>50mL. Those who meet ①, ②, ③, ④ or ⑤ can be diagnosed with benign prostatic hyperplasia.

[0052] TCM syndrome standard: The cases selected for this study were formulated with reference to the "TCM Diagnosis and Syndrome Differentiation Standard for Benign Prostatic Hyperplasia" in the "Guidelines for Clinical Research of New Chinese Medicines". (1) Main symptoms: urination is difficult and the frequency of nocturia increases; (2) Secondary symptoms: ① Weakness of waist and knees, chills and cold limbs, fatigue; ② Thin urine stream, intermittent or no urine stream; ③ Fullness, distension or pain in the lower abdomen; ④ Pale tongue, weak and thin pulse. Anyone with any of the above main and secondary symptoms can be diagnosed with benign prostatic hyperplasia (urinary retention and kidney yang deficiency syndrome).

[0053] 1.2 Inclusion criteria

[0054] ① Male aged 50-80 years; ② Disease course of more than three months, and no formal treatment for prostate hyperplasia; ③ Meet the Western medicine diagnostic criteria and TCM syndrome criteria for BPH; ④ International Prognostic Scoring System (IPSS) score ≥ 8 points; ⑤ Maximum urine flow rate (Qmax) <15mL / s; ⑥ Prostate volume >20mL; ⑦ Able to adhere to treatment as required and agree to relevant follow-up; ⑧ Symptoms such as frequent urination, urgency, and difficulty urinating caused by prostate hyperplasia are significantly more severe in winter than in other seasons.

[0055] 1.3 Exclusion criteria

[0056] ① Age <50 or >80 years old; ② Allergic to the study drugs or allergic constitution; ③ Combined with serious primary diseases such as cardiovascular, cerebrovascular, liver, kidney and hematopoietic system, refractory diabetes and glycosuria; ④ Mental illness; ⑤ Dysuria caused by neurogenic bladder, bladder neoplasms, bladder neck fibrosis, hypertrophy of the ureteral ridges, hypertrophy of the seminal fossa, and urethral stenosis; ⑥ Oliguria or anuria caused by urethral stones, prostate cancer, acute and chronic renal failure; ⑦ Pelvic surgery or loss; ⑧ Taking drugs that may affect bladder outlet function; ⑨ Serum prostate-specific antigen (PSA) >10ng / mL; ⑩ Failure to receive treatment and cooperate with follow-up as required.

[0057] 1.4 Basic Information

[0058] Fifty patients with benign prostatic hyperplasia treated in the urology outpatient clinic and inpatient ward of Longhua Hospital from 2021 to 2023 were selected.

[0059] 2. Treatment Methods

[0060] (1) Check the doctor's orders, assess the patient, and explain the situation. Instruct the patient to avoid drafts and adjust the room temperature.

[0061] (2) Heating the Chinese medicine ironing hot pack prepared in Example 1: Sprinkle 2 mL of sterile water on the surface of the hot pack before operation. After the surface of the hot pack is slightly damp, place it in a microwave oven and heat it on low heat for about 2 minutes. The temperature of the hot pack is preferably 50° C.-60° C.

[0062] (3) Prepare all the necessary supplies (treatment tray, spray bottle, Chinese medicine bag, treatment towel or non-woven fabric, towel (self-provided), water thermometer, fixing buckle, and if necessary, blanket, gauze, screen, etc.) and bring them to the bedside.

[0063] (4) Lie flat on your back, expose the treatment area, and recheck the local skin condition. If necessary, use a screen to cover the patient.

[0064] (5) Apply the heated Chinese medicine hot pack to the designated acupuncture points (urinary obstruction acupuncture points: Guanyuan, Zhongji, Shuidao) according to the doctor's instructions and fasten with buckles. Keep warm, observe the patient's skin reaction, and ask the patient about their feelings. The temperature should be appropriate for the patient tolerable. If the temperature of the medicine bag is too low, replace the medicine bag or heat it in time. Each treatment time is about 20-30 minutes. After the fixed ironing treatment, you can also take the hot pack and move it along the abdominal route of the Governor Vessel, Kidney Meridian, and Stomach Meridian from top to bottom to the bladder perineum and iron it repeatedly for 20-30 times. This can be done once a day. If the patient feels the urge to urinate during the process, he can be asked to carry the hot pack with the buckle fixed to the bladder and sit to urinate.

[0065] (6) During the hot compress application, pay attention to the color of the local skin and promptly ask the patient about his or her perception of the temperature.

[0066] (7) After the operation, clean the local skin, help the patient to dress, and arrange a comfortable position. Instruct the patient to avoid wind and keep warm, and drink plenty of warm water.

[0067] Once a day for one month as a course of treatment.

[0068] 3. Observation items and methods

[0069] 3.1 Observation indicators

[0070] Efficacy indicators: International Prostate Symptom Score (IPSS), quality of life (QOL), and traditional Chinese medicine syndrome score;

[0071] Safety indicators: General physical examination items: blood pressure, heart rate; laboratory tests: blood and urine routine tests; electrocardiogram, liver function (ALT), and kidney function (BUN, Scr) tests.

[0072] 3.2 Criteria for evaluating efficacy

[0073] Referring to the relevant diagnostic principles and severity standards of benign prostatic hyperplasia in the "Guidelines for Clinical Research of New Traditional Chinese Medicines" of the State Food and Drug Administration, the indicators were graded into clinical control, markedly effective, effective, and ineffective.

[0074] Clinical control: The main symptoms disappear and the syndrome scores are reduced by 90% or more.

[0075] Markedly effective: The main symptoms disappeared and the syndrome score decreased by 60-89%.

[0076] Effective: Major symptoms improved and syndrome scores decreased by 30-59%.

[0077] Ineffective: The main symptoms and various indicators did not change significantly or worsened, and the syndrome score decreased by less than 30%.

[0078] 3.3 Statistical methods

[0079] After the clinical data were collected, all the data were established in a database. The professional statistical software package SPSS25.0 was used for statistical analysis. The measurement data were expressed as mean and standard deviation ( ) description, independent sample t test was used for comparison of differences for data that met normal distribution, rank sum test (Mann-Whitney U test) was used for measurement data with non-normal distribution; rank sum test and chi-square test were used for count data. Hypothesis tests uniformly used two-sided tests, and test statistics and their corresponding P values ​​were given, with P < 0.05 considered statistically significant.

[0080] 4. Results

[0081] 4.1 Case completion status

[0082] 50 patients were observed one month after treatment, 2 patients dropped out (lost to follow-up), and 48 patients completed follow-up after one month of treatment for efficacy evaluation. Main observation index detection: 48 patients had a marked efficacy rate of 4.17%, an effective rate of 27.08%, an ineffective rate of 68.75%, and a total effective rate of 31.25%. The specific results are shown in Table 1.

[0083] Table 1 Clinical efficacy determination results

[0084]

[0085] One month after treatment, the International Prostate Symptom Score (IPSS), the impact of urination symptoms on quality of life (QOL), and the TCM syndrome score were significantly improved compared with those before treatment (P<0.05), as shown in Table 2.

[0086] Table 2 Summary of symptom scores

[0087]

[0088] Note: ▲ Indicates P<0.05 compared with before treatment.

[0089] 4.2 Incidence of adverse events

[0090] During the treatment period, one patient in the treatment group experienced adverse reactions, such as itching, redness, and skin allergies at the application site; the adverse reaction rate was 2.08% (1 / 48). Comparison of the blood pressure, heart rate, blood routine, renal function, liver function, and electrocardiogram test results before and after treatment showed no significant changes in the other patients.

[0091] Conclusion of the experiment: The Chinese medicine ironing hot pack provided by the present invention can reduce IPSS score, improve urination symptoms, relieve TCM symptoms, have few side effects, and is clinically safe and effective in treating benign prostatic hyperplasia. The Chinese medicine ironing hot pack preparation provided by the present invention combined with modern drugs to treat urination disorders caused by chronic non-bacterial prostatitis can more significantly relieve patients' pain, frequent urination, urgency and other urination symptoms compared to the use of modern drugs alone, improve their quality of life, and is safe and effective.

[0092] Example 3

[0093] 1. Case selection

[0094] 1.1 Diagnostic criteria

[0095] The diagnostic criteria for chronic nonbacterial prostatitis refer to the relevant standards of the National Institutes of Health (NIH) of the United States: ① Abnormal urination: frequent urination, urgency, incomplete urination, and even white dripping; ② Pelvic soreness and pain; ③ Prostate anal examination: the surface of the prostate is uneven and asymmetrical, irregular nodules can be touched, and tenderness; ④ Laboratory examination shows normal urine routine, negative bacterial culture of prostatic fluid, and white blood cells in prostate routine are within the normal range (WBC≤5 / HP).

[0096] The diagnosis of damp-heat and blood stasis syndrome in traditional Chinese medicine refers to the standards in the "Expert Consensus on the Diagnosis and Treatment of Chronic Prostatitis Combined with Traditional Chinese and Western Medicine" and the "Guidelines for the Diagnosis and Treatment of Chronic Prostatitis / Chronic Pelvic Pain Syndrome": residual urination after urination, burning and astringent urination, or discomfort in the perineum, accompanied by pain or tingling in the perineum, scrotum, testicles, etc., fullness in the lower abdomen, a sense of obstruction when the urine flow is thin, and even thin and weak urine dripping out. The tongue is dark red with visible petechiae, the veins under the tongue are visible, and the pulse is thin and rapid or astringent.

[0097] 1.2 Inclusion criteria

[0098] ①Meet the above-mentioned Western medicine diagnostic criteria and TCM syndrome diagnostic criteria; ②Male, aged 20-50 years old; ③This study was reviewed and approved by the hospital ethics committee, and the patient signed the informed consent.

[0099] 1.3 Exclusion criteria

[0100] ① Patients with prostate tumors and prostate hyperplasia; ② Patients with liver and kidney dysfunction and severe cardiovascular and cerebrovascular diseases; ③ Patients with poor compliance; ④ Patients with allergic constitution or mental illness.

[0101] 1.4 General Information

[0102] The 90 cases in this embodiment were all from the Urology Department of Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from January 2023 to September 2024, and were clearly diagnosed with chronic non-bacterial prostatitis with damp-heat and blood stasis. According to the random number table method, they were divided into a treatment group and a control group, with 45 cases in each group. There was no significant statistical difference in the average age and average course of disease between the treatment group and the control group (P>0.05).

[0103] 2. Treatment Methods

[0104] 2.1 Control group

[0105] The patient was given Zisuo (Tamsulosin Hydrochloride Sustained Release Capsules) 0.2 mg (Zhejiang Hailisheng Pharmaceutical Co., Ltd.; batch number: National Medicine Standard H20020623) orally, once a day, 1 capsule each time. The course of treatment was 1 month.

[0106] 2.2 Treatment groups

[0107] The Chinese medicine ironing hot pack preparation prepared in Example 1 was added to the control group, and the detailed steps were the same as "5. Treatment Method" in Example 2, once a day, and each treatment lasted about 20-30 minutes. The course of treatment was 1 month.

[0108] 3. Observation items and methods

[0109] 3.1 Clinical efficacy

[0110] After the treatment, the clinical efficacy was determined by referring to the relevant standards in the "Expert Consensus on the Diagnosis and Treatment of Chronic Prostatitis with Integrated Traditional Chinese and Western Medicine" and the "Guidelines for the Diagnosis and Treatment of Chronic Prostatitis with Integrated Traditional Chinese and Western Medicine (Trial Version)". TCM symptom scoring standards and efficacy evaluation standards: According to Zheng Xiaoyu's "Trial Guidelines for Clinical Research of New Chinese Medicines" and the 2020 "Guidelines for the Diagnosis and Treatment of Chronic Prostatitis with Integrated Traditional Chinese and Western Medicine", a TCM symptom score quantitative scoring table was developed, and the TCM symptoms of the two groups of patients were scored before and after treatment.

[0111] The main symptoms (frequent and urgent urination, burning sensation in the urethra, residual urine after urination, pain or discomfort in the lower abdomen, pain or discomfort in the perineum, pain or discomfort in the lumbar region) and the secondary symptoms (wet scrotum, white discharge after urination, testicular pain) were divided into 4 levels according to the frequency of occurrence. The main symptoms were scored as 0, 2, 4, and 6 points, and the secondary symptoms were scored as 0, 1, 2, and 3 points. The specific description of the tongue and pulse was not included in the scoring.

[0112] TCM symptom efficacy evaluation criteria:

[0113] 1) Cured: TCM symptoms have basically disappeared or completely disappeared, and the TCM symptom score has decreased by ≥95% compared with before treatment

[0114] 2) Significant effect: TCM symptoms were significantly relieved, and the TCM symptom score decreased by ≥60% and <95% compared with before treatment;

[0115] 3) Effective: TCM symptoms were relieved, and the TCM symptom score decreased by ≥30% and <60% compared with before treatment;

[0116] 4) Ineffective: TCM symptoms are not relieved or aggravated, and the TCM symptom score is reduced by less than 30% compared with before treatment;

[0117] Efficacy calculation formula:

[0118] Efficacy = [(total score of TCM symptoms before treatment - total score of TCM symptoms after treatment) / total score of TCM symptoms before treatment] × 100%.

[0119] 3.2 Chronic Prostatitis Symptom Index (NIH-CPSI score)

[0120] Before and after treatment, the subjects' pain, urination, and quality of life were scored and evaluated with reference to the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI), and the total score was calculated.

[0121] 3.3 Routine related indicators of prostatic fluid

[0122] The prostatic fluid of the subjects before and after treatment was collected for routine prostate examination and bacterial culture, and the changes in white blood cell (WBC) and phosphatidylcholine body (SPL) indicators were recorded.

[0123] 3.4 Statistical methods

[0124] The experimental data were statistically analyzed using SPSS 25.0 software. If the data were normally distributed and had equal variance, the t test was used; if the data were not normally distributed, the t' test was used. The rank sum test was used for the rank data. P < 0.05 was considered statistically significant.

[0125] 4. Test results

[0126] 4.1 Case completion status

[0127] 90 patients were observed one month after treatment, 3 patients dropped out (lost to follow-up) in the treatment group and 3 patients in the control group, and 84 patients completed follow-up after efficacy evaluation one month after treatment.

[0128] 4.2 Comparison of clinical efficacy

[0129] The total clinical efficacy of the treatment group and the control group were 54.76% and 28.57% respectively; the clinical efficacy of the treatment group was significantly better than that of the control group (P < 0.05). See Table 3.

[0130] Table 3 Comparison of clinical efficacy between the two groups (cases)

[0131]

[0132] Note: * indicates comparison with the control group, P<0.05.

[0133] 4.3 Changes in NIP-CPSI scores

[0134] Before and after treatment, the intra-group comparison showed that the pain, urination, symptom quality of life scores and CPSI total score were significantly different between the two groups (P < 0.05); the inter-group comparison showed that the pain, urination, quality of life scores and CPSI total score were significantly different (P < 0.05). See Table 4.

[0135] Table 4 Comparison of changes in NIH-CPSI scores between the treatment group and the control group ( )

[0136]

[0137] Note: Compared with the same group before treatment, * indicates P < 0.05; compared with the control group after treatment, # indicates P < 0.05.

[0138] 4.4 Changes in routine indicators of prostatic fluid

[0139] The intra-group comparison before and after treatment showed that the differences in WBC and SPL levels between the two groups were statistically significant (P < 0.05); the inter-group comparison after treatment showed that the improvement in WBC and SPL levels in the treatment group was significantly better than that in the control group (P < 0.05). See Table 3.

[0140] Table 5 Comparison of changes in routine indicators of prostatic fluid between the treatment group and the control group ( )

[0141]

[0142] Note: Compared with the same group before treatment, * indicates P < 0.05; compared with the control group after treatment, # indicates P < 0.05

[0143] Incidence of Adverse Events During the treatment period, 3 cases in the treatment group and 3 cases in the control group developed orthostatic hypotension, and the side effects were relieved after medication guidance. One case in the treatment group experienced itching, redness, and skin allergy at the application site; the adverse reaction rate was 2.38% (1 / 42).

[0144] The test results in this example show that the Chinese medicine ironing hot package preparation provided by the present invention combined with modern drugs for the treatment of urination disorders caused by chronic non-bacterial prostatitis can more significantly relieve patients' urination symptoms such as pain, frequent urination, and urgency, improve their quality of life, and is safe and effective compared to the use of modern drugs alone.

[0145] Example 4

[0146] The efficacy of the Chinese medicine ironing hot pack preparation prepared in Example 1 and the Chinese medicine ironing hot pack preparation prepared in Comparative Example 1 were compared, and the experiment was as follows:

[0147] 1. Materials and methods

[0148] 1.1 General Information

[0149] A total of 90 middle-aged and elderly male patients who underwent surgical treatment for mixed hemorrhoids from 2019 to 2020 were randomly divided into 2 groups, with 45 cases in each group. There were 45 cases in the control group, aged 45 to 60 years old, with an average age of (51.9±6.4) years old; there were 45 male patients in the experimental group; aged 45 to 64 years old, with an average age of (53.1±6.2) years old; they agreed to surgical treatment, and the age and other data were entered into the software, and there was no significant difference (P>0.05).

[0150] 1.2 Treatment methods

[0151] The control group adopted the initial version of the whole equal parts of Chinese medicine ironing hot pack preparation in comparative example 1, and the experimental group adopted the Chinese medicine ironing hot pack preparation in example 1. The relevant operation of the hot pack was the same as "2. Treatment method" in example 2; the operation was consistent to prevent urinary retention, and the blood in the stool should be closely observed after the operation. Once symptoms such as palpitations, pale complexion, and thin pulse were found, the doctor should be informed in time. At the same time, the patient was assisted to take the side-lying position after the operation to prevent the wound from being compressed and aggravating the pain. At the same time, the head of the bed was appropriately raised to reduce abdominal muscle tension, increase bladder pressure, and promote autonomous urination.

[0152] In addition, warm compresses were applied and patients were advised to keep the anus clean. Their diet should mainly consist of easily digestible foods. They were advised to quit smoking and drinking and avoid eating irritating foods.

[0153] 1.3 Observation indicators: The first urination time, postoperative urine retention index and satisfaction were compared between the two groups. The satisfaction evaluation was judged by the satisfaction survey scale developed by our hospital. The full score of the scale is 100 points. Very satisfied: score > 70 points, satisfied: score 40-70 points, dissatisfied: score < 40 points. The sum of the very satisfied rate and the satisfied rate is used to express the satisfaction result after the survey.

[0154] 1.4 Statistical methods: SPSS 19.0 statistical software was used, and the measurement data were expressed as mean with standard deviation ( ) were used for comparison between groups; count data were expressed as percentage (%) and were compared with t test. P < 0.05 indicated statistically significant differences.

[0155] 2. Results

[0156] 2.1 Comparison of the first urination time between the two groups: The first urination time of the experimental group was (173.3±78.4) min, which was shorter than that of the control group (202.7±85.9) min, with a significant difference (P<0.05).

[0157] 2.2 Comparison of the incidence of urinary retention: The incidence of urinary retention in the control group was 15.56% (7 / 45), which was higher than 8.89% (4 / 45) in the experimental group, with no significant difference (P>0.05)

[0158] 2.3 Comparison of satisfaction survey results: The satisfaction rate of the experimental group was 68.9%, which was higher than that of the control group (46.7%), with a significant difference (P<0.05), as shown in Table 6.

[0159] Table 6 Satisfaction data survey results

[0160] Group Number of cases Very satisfied satisfy Dissatisfied Satisfaction (%) Experimental group (Example 1) 45 17 14 14 68.9* Control group (Comparative example 1) 45 16 5 24 46.7 <![CDATA[X 2 ]]> 6.925 P 0.031

[0161] Conclusion: Compared with the initial drug ratio of equal parts, the drug ratio of the present invention can shorten the postoperative urination time and has higher patient satisfaction. Obviously, the ratio is more optimized.

[0162] The embodiments described above are only descriptions of the preferred modes of the present invention, and are not intended to limit the scope of the present invention. Without departing from the design spirit of the present invention, various modifications and improvements made to the technical solutions of the present invention by ordinary technicians in this field should all fall within the protection scope determined by the claims of the present invention.

Claims

1. A pharmaceutical composition for treating urination disorders, characterized in that: Includes the following ingredients: Pyrrosia, Sarcandra chinensis, Polygonum cuspidatum, Ligusticum chuanxiong, Clematis chinensis, Cuminum foenum and dried ginger.

2. The pharmaceutical composition according to claim 1, characterized in that By weight, it includes the following components: 15 parts of Pyrola, 30 parts of Sargentodoxae, 15 parts of Polygonum cuspidatum, 15 parts of Rhizoma Chuanxiong, 15 parts of Fructus Liquidambar, 12 parts of Fennel and 12 parts of Drynariae Zingiberis.

3. Use of the pharmaceutical composition according to claim 1 or 2 in the preparation of a drug for treating urination disorders.

4. The use according to claim 3, characterized in that The urination disorder is urination disorder caused by prostate disease or surgical treatment.

5. The use according to claim 4, characterized in that The prostate disease is benign prostatic hyperplasia or chronic nonbacterial prostatitis.

6. A drug for treating urination disorders, characterized in that: The only active ingredient of the drug is the pharmaceutical composition according to claim 1 or 2.

7. The drug according to claim 6, characterized in that Pharmaceutically acceptable excipients are also included.

8. The drug according to claim 6 or 7, characterized in that The dosage form of the medicine is a traditional Chinese medicine ironing hot pack preparation.

9. A method for preparing a traditional Chinese medicine ironing hot pack preparation for treating urination disorders, characterized in that: include: Weigh the pharmaceutical composition according to claim 1 or 2 according to weight, grind them into coarsest powder respectively, mix them evenly, and obtain mixed powder; The Chinese medicine ironing hot bag preparation is obtained by bagging.

10. The preparation method according to claim 9, characterized in that: The bagging is to pack the mixed powder into a non-woven bag according to a specification of 60g / bag.

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