Radio frequency plasma self-adapting resonance virtual electrode device

Abstract

The application belongs to the technical field of medical equipment, and particularly relates to a radio frequency plasma self-adaptive resonance virtual electrode device. The device comprises a radio frequency power supply, a Tesla coil, a copper cylinder, a virtual electrode and a lower plate. The radio frequency power supply is connected to the primary coil of the Tesla coil through a coaxial transmission line, and the Tesla coil is powered. The primary coil and the secondary coil of the Tesla coil are magnetically coupled and resonated. The copper cylinder extending from the secondary coil breaks the inert gas in the virtual electrode, thereby forming a plasma region. The application utilizes the Tesla coil to generate a strong electromagnetic field, breaks the inert gas in the virtual electrode to form a plasma region, and automatically changes the discharge area of the radio frequency plasma to compensate the capacitance value to LC resonance as the load changes. The virtual electrode can change the discharge region in real time and self-adaptively, and the effect of self-adaptive impedance matching is achieved without using a radio frequency impedance matcher.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical equipment, and in particular relates to a radio frequency plasma adaptive resonant virtual electrode device. Background Art

[0002] An impedance matcher is a device that precisely adjusts and optimizes the output and input impedance matching relationship between two connected circuits. Ideally, optimal transmission is achieved when the load impedance is equal to the characteristic impedance of the transmission line. This impedance state prevents energy reflection, ensuring a smooth transition of the signal wavefront and eliminating reflected waves. This allows all energy to be fully absorbed and utilized by the load, significantly improving energy transmission efficiency.

[0003] Cancer treatments mainly include chemotherapy, radiotherapy, and immunotherapy, but these traditional treatments often cause certain toxic side effects to patients. While killing cancer cells, they also damage normal body cells, which can also cause certain harm to patients. Cancer cells are mutated human cells. Cancer cells are more susceptible to heat than normal cells. At a temperature of 42 degrees, cancer cells will be killed after a period of time, but the tolerance limit of normal tissue cells is around 45 degrees. Raising the temperature to 42 to 44 degrees can destroy tumor cells without damaging normal tissue cells. Non-invasive tumor cell apoptosis technology mainly induces programmed cell death in tumor cells through external means without directly invading the patient's body. This method can evenly heat tumor cells and is less invasive and has a faster recovery than traditional surgery.

[0004] In "Research and Implementation of Automatic RF Impedance Matching Methods [D]. Zhengzhou University, 2017," Lu Hui designed an automatic RF impedance matcher using the Smith chart's changing patterns. This device utilizes a Rogowski coil, a capacitive voltage divider, an AD8302 amplitude-to-phase converter, an STM32F103ZE processor, and a stepper motor to achieve automatic impedance matching. However, the stepper motor is a bulky and slow execution module, which is inconsistent with the high efficiency required by modern industry. Furthermore, the matching process takes up to 3 seconds, which is quite long.

[0005] Chakarvarti SK et al. introduced local, regional, and whole-body hyperthermia methods in "Hyperthermia techniques for cancer treatment: A review [J]. Int. J. PharmTech Res, 2015, 8(6): 292-299." Various types of external applicators have been designed to directly control the thermal dose rather than using elevated temperatures for treatment. Experimental research results have shown that hyperthermia is an ideal supplemental treatment and strong sensitizer for radiotherapy and many cytotoxic drugs, and it has been proven to be one of the best cancer treatment options. However, the control of the thermal dose during hyperthermia therapy requires very precise control and is difficult to control.

[0006] Mi Yan et al. studied the effects of pulse width, electric field intensity, repetition frequency within a pulse train, and the number of pulses within a pulse train on cell apoptosis and cell necrosis rates in "Experimental study on the killing effect of high-frequency nanosecond pulse trains on skin cancer cells [J]. High Voltage Technology, 2018, 44(02): 584-590." They analyzed the influence of each parameter on cell apoptosis and cell necrosis rates. However, the cell apoptosis rate is still relatively low, and further research is needed to use a multi-parameter fitting method to obtain the relationship between each parameter and the cell apoptosis and cell necrosis rates.

[0007] In "Numerical Simulation and Quality Study of Radio Frequency Thawing of Frozen Hairtail [D]. Jiangnan University, 2023. DOI: 10.27169 / d.cnki.gwqgu.2023.001788," Jiang Hanting constructed an electromagnetic-thermal coupling model of the radio frequency thawing process for hairtail using finite element analysis. The accuracy of the numerical simulation results was verified experimentally. The paper further evaluated the effects of natural thawing, low-temperature thawing, and radio frequency thawing on the thawing efficiency and quality of frozen hairtail, and analyzed the mechanism by which radio frequency thawing affects the quality characteristics of hairtail. However, it did not consider whether the impedance characteristics of the entire system change when different individuals are added, thereby affecting the electromagnetic field changes in the two electrodes.

[0008] Chinese patent document CN111840807A discloses a microwave radio frequency coordinated rotational irradiation tumor full-area hyperthermia device, which provides deep and shallow layered complementary thermal penetration to the human body, achieving full-area precise high-fever heat, and is used to cure tumors. However, the device requires cooling the fat areas at both ends during heating.

[0009] Chinese patent publication CN118415289A discloses a radio frequency thawing device and electrical equipment that achieves the effect of quickly thawing frozen objects within the device. However, the impedance matching of the tuned inductor module in the device cannot keep up with the impedance changes of the capacitive load, resulting in low radio frequency energy efficiency and failing to achieve the application purpose.

[0010] In summary, in the use of non-invasive tumor cell apoptosis technology and radio frequency thawing technology, the traditional radio frequency matching device has hysteresis, and the impedance matching cannot keep up with the impedance change of the load. Therefore, how to develop a device that can achieve real-time adaptive impedance matching is a problem that needs to be solved at present. SUMMARY

[0011] The purpose of the present application is to overcome the above-mentioned problems existing in the prior art, and to provide a radio frequency plasma adaptive resonance virtual electrode device.

[0012] In order to achieve the above technical purpose and achieve the above technical effect, the present application is realized by the following technical scheme:

[0013] The present application provides a radio frequency plasma adaptive resonance virtual electrode device, comprising a radio frequency power supply, a primary coil, a secondary coil, a copper cylinder, a virtual electrode and a lower plate; the primary coil and the secondary coil are combined to form a Tesla coil, the radio frequency power supply is connected to the primary coil of the Tesla coil through a coaxial transmission line, the primary coil and the secondary coil are wound on the same plastic tube in an up-down manner, the extension end of the secondary coil is connected with the copper cylinder, the virtual electrode is placed 2mm below the copper cylinder, and the lower plate is grounded and placed below the virtual electrode; the primary coil can be magnetically coupled with the secondary coil to resonate, and the copper cylinder connected with the secondary coil can break down the inert gas in the virtual electrode to form a plasma region; the plasma region changes adaptively to compensate the capacitance value to achieve resonance state.

[0014] Further, in the above-mentioned radio frequency plasma adaptive resonance virtual electrode device, the frequency of the radio frequency power supply is set to 13.56MHz.

[0015] Further, in the above-mentioned radio frequency plasma adaptive resonance virtual electrode device, the primary coil is wound by 5 turns of hollow copper wire, and the secondary coil is wound by 68 turns of enameled wire.

[0016] Further, in the above-mentioned radio frequency plasma adaptive resonance virtual electrode device, the diameter of the copper cylinder is 25mm, and the thickness is 3mm.

[0017] Further, in the above-mentioned radio frequency plasma adaptive resonance virtual electrode device, the virtual electrode is a quartz cup body with a diameter of 50mm and a height of 40mm, the quartz cup body is provided with a cylindrical cavity with a height of 26mm and an inner diameter of 26mm, and the inside of the cylindrical cavity is filled with inert gas.

[0018] Further, in the above-mentioned radio frequency plasma adaptive resonance virtual electrode device, the lower plate is a copper plate with a diameter of 150mm and a thickness of 0.5mm.

[0019] Further, the above-mentioned radio frequency plasma self-adaptive resonance virtual electrode device further comprises a water-cooled circulating radiator, the radio frequency power supply is arranged outside the device shell, the primary coil, the secondary coil, the copper cylinder connected with the secondary coil, the virtual electrode, the lower plate and the water-cooled circulating radiator are arranged inside the device shell, the water-cooled circulating radiator is used for temperature control of the internal environment of the device shell, and the radio frequency power supply and the device shell are placed in a normal temperature room.

[0020] Further, the method for using the above-mentioned radio frequency plasma self-adaptive resonance virtual electrode device comprises the following steps:

[0021] S1, connecting the radio frequency power supply to the primary coil through the coaxial transmission line, so as to supply power to the Tesla coil;

[0022] S2, the primary coil and the secondary coil of the Tesla coil produce magnetic coupling resonance, the copper cylinder connected with the secondary coil breaks down the inert gas in the virtual electrode, forms a plasma region and generates an electromagnetic field;

[0023] S3, the discharge area of the radio frequency plasma is automatically changed to compensate the capacitance value to LC resonance, so as to realize self-adaptive impedance matching.

[0024] The beneficial effects of the present application are as follows:

[0025] The radio frequency plasma self-adaptive resonance virtual electrode device provided by the present application has reasonable design, the frequency of the radio frequency power supply is set to 13.56 MHz, the radio frequency wave is radiated to the Tesla coil through the connecting circuit, the primary coil and the secondary coil of the Tesla coil produce magnetic coupling resonance, the voltage is boosted through the Tesla coil, the copper cylinder connected with the secondary coil breaks down the inert gas in the virtual electrode to form a plasma region, when the capacitance of the capacitive load becomes smaller, the discharge area of the radio frequency plasma is automatically increased to increase the equivalent capacitance, and the capacitance value is compensated to LC resonance; otherwise, the same effect is achieved. The virtual electrode can change the discharge area in real time and adaptively, and the effect of self-adaptive impedance matching is achieved, and the radio frequency impedance matcher is not needed, so that the principle sample structure of the capacitive load application device with simple structure, low cost and high efficiency is realized.

[0026] Of course, any product implementing the present application does not necessarily need to achieve all the advantages above at the same time. BRIEF DESCRIPTION OF DRAWINGS

[0027] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings needed for the embodiment description will be briefly introduced as follows. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative labor.

[0028] Figure 1 Connection circuit diagram of the device of the present application;

[0029] Figure 2 Structure schematic diagram of the device of the present application;

[0030] Figure 3 Electric field distribution diagram for changing the distance between the upper and lower plates;

[0031] Figure 4 Electric field distribution diagram for changing the diameter of the upper plate;

[0032] Figure 5 Experimental diagram for changing the distance between the plates;

[0033] Figure 6 Experimental diagram for changing the medium between the two plates;

[0034] In the drawings, the reference numerals of the components are as follows:

[0035] 1 - RF power supply, 2 - primary coil, 3 - secondary coil, 4 - copper cylinder, 5 - virtual electrode, 6 - lower plate, 7 - water-cooled circulating radiator. DETAILED DESCRIPTION

[0036] The technical solutions in the embodiments of the present application will be described clearly and completely below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative labor fall within the scope of protection of the present application.

[0037] As shown in Figures 1-6 The present embodiment provides a radio frequency plasma self-adaptive resonance virtual electrode device, which comprises an RF power supply 1, a primary coil 2 of a Tesla coil, a secondary coil 3 of the Tesla coil, a copper cylinder 4 connected to the secondary coil, a virtual electrode 5, a lower plate 6, and a water-cooled circulating radiator 7. The RF power supply 1 is connected to the primary coil 2 of the Tesla coil through a coaxial transmission line, the primary coil 2 of the Tesla coil is magnetically coupled and resonates with the secondary coil 3 of the Tesla coil, and the copper cylinder 4 connected to the secondary coil breaks down the inert gas in the virtual electrode 5 to form a plasma region and generate an electromagnetic field.

[0038] The Tesla coil consists of a primary coil 2 and a secondary coil 3. The primary coil is wound with 5 turns of hollow copper wire, and the secondary coil is wound with 68 turns of enameled wire. A copper cylinder with a diameter of 25 mm and a thickness of 3 mm is connected to the secondary coil of the Tesla coil. The virtual electrode is a quartz cup with a diameter of 50 mm and a height of 40 mm. The inner recessed cup has a height of 26 mm and an inner diameter of 26 mm. By boosting the voltage of the Tesla coil, the copper cylinder breaks through the inert gas in the virtual electrode, forming a plasma region and generating an electromagnetic field. An object containing tumor cells is then placed in the electromagnetic field generated between the upper and lower electrodes and heated, achieving non-invasive tumor cell apoptosis.

[0039] In this embodiment, both the primary and secondary coils of the Tesla coil have self-inductance, and there is mutual inductance between the coils. When the frequency is set to 13.56 MHz, the hollow copper wire and the enameled wire can be equivalently regarded as the coil inductance, thereby forming a resonant circuit. The electric field generated by the device designed in this example at an operating frequency of 13.56 MHz is most effective for non-invasive tumor cell apoptosis and efficient radiofrequency thawing.

[0040] like Figure 2 As shown, for the two application directions of non-invasive tumor cell apoptosis and efficient radiofrequency thawing, the structure of the virtual electrode 5 needs to be changed based on the different target objects.

[0041] like Figure 3 and Figure 4 As shown in the figure, the electric field distribution between the upper and lower plates is simulated when different objects are placed and the capacitance changes.

[0042] like Figure 5 and Figure 6 As shown, Figure 5 In order to change the experimental phenomenon of the distance between the upper and lower plates, the distance between the upper and lower plates is gradually increased, and the plasma discharge area in the virtual electrode is also gradually increased. Figure 6 This is an experimental phenomenon of placing different media. When a copper plate is placed, the plasma discharge area in the cup becomes smaller; when an aqueous solution is placed, the discharge area becomes larger than when a copper plate is placed.

[0043] This embodiment also provides a method for using the radio frequency plasma adaptive resonant virtual electrode device, which includes the following steps:

[0044] An RF power source 1 is connected to the primary coil 2 of a Tesla coil via a coaxial transmission line. This creates magnetic coupling resonance with the secondary coil 3. A copper cylinder 4 connected to the secondary coil breaks down the inert gas in a virtual electrode 5, forming a plasma region and generating an electromagnetic field. An organism containing cancer cells is placed on the lower electrode plate 6, and a water-cooled circulating radiator 7 is activated.

[0045] The copper material used in the primary coil 3 of the Tesla coil has excellent conductivity, the copper coil is flexible and easy to bend, safe, stable and reliable, and has higher transmission efficiency. The plasma discharge area in the virtual electrode 5 automatically changes, compensating the capacitance value to LC resonance. The virtual electrode can change the discharge area in real time and adaptively, achieving the beneficial effects of adaptive impedance matching, and achieving the advantages of simple structure, low cost and high efficiency. The water-cooled circulating radiator 7 can keep the coil temperature at a low level, greatly alleviating the problem of long-term work caused by coil heating.

[0046] The preferred embodiments of the application disclosed above are only used to help explain the application. The preferred embodiments do not describe all the details and limit the application to the specific embodiments. Obviously, many modifications and changes can be made according to the content of the specification. The specification selects and describes these embodiments in order to better explain the principles and practical applications of the application, so that those skilled in the art can well understand and use the application. The application is limited by the claims and their full scope and equivalents.

Claims

1. Radio frequency plasma adaptive resonant virtual electrode device, characterized in that: The invention comprises a radio frequency power supply (1), a primary coil (2), a secondary coil (3), a copper cylinder (4), a virtual electrode (5) and a lower plate (6); the primary coil (2) and the secondary coil (3) are combined to form a Tesla coil, the radio frequency power supply (1) is connected to the primary coil (2) of the Tesla coil via a coaxial transmission line, the primary coil (2) and the secondary coil (3) are respectively wound on the same plastic tube, the extended end of the secondary coil (3) is connected to the copper cylinder (4), the virtual electrode (5) is placed 2 mm below the copper cylinder (4), and the lower plate (6) is grounded and placed below the virtual electrode (5); the primary coil (2) can generate magnetic coupling resonance with the secondary coil (3), and the copper cylinder (4) connected to the secondary coil (3) can break through the inert gas in the virtual electrode (5), thereby forming a plasma region; the plasma region adaptively changes the compensation capacitance value as different media are placed to achieve a resonant state; The virtual electrode (5) is a quartz cup with a diameter of 50 mm and a height of 40 mm. A cylindrical cavity with a height of 26 mm and an inner diameter of 26 mm is provided inside the quartz cup. The interior of the cylindrical cavity is filled with an inert gas.

2. The RF plasma adaptive resonant virtual electrode device according to claim 1, characterized in that: The frequency of the radio frequency power supply (1) is set to 13.56 MHz.

3. The RF plasma adaptive resonant virtual electrode device according to claim 1, characterized in that: The primary coil (2) is wound with 5 turns of hollow copper wire, and the secondary coil (3) is wound with 68 turns of enameled wire.

4. The RF plasma adaptive resonant virtual electrode device according to claim 1, characterized in that: The copper cylinder (4) has a diameter of 25 mm and a thickness of 3 mm.

5. The RF plasma adaptive resonant virtual electrode device according to claim 1, characterized in that: The lower electrode plate (6) is a copper plate with a diameter of 150 mm and a thickness of 0.5 mm.

6. The radio frequency plasma adaptive resonant virtual electrode device according to claim 1, characterized in that: The device further comprises a water-cooled circulating radiator (7), wherein the radio frequency power supply (1) is arranged outside the device housing, and the primary coil (2), the secondary coil (3), the copper cylinder (4) connected to the secondary coil, the dummy electrode (5), the lower plate (6) and the water-cooled circulating radiator (7) are arranged inside the device housing, and the water-cooled circulating radiator (7) is used to control the temperature of the internal environment of the device housing; the radio frequency power supply (1) and the device housing are placed in a room temperature chamber.

7. The radio frequency plasma adaptive resonant virtual electrode device according to any one of claims 1 to 6, characterized in that: The method of use includes the following steps: S1. Connecting a radio frequency power source (1) to the primary coil (2) via a coaxial transmission line to power the Tesla coil; S2, the primary coil (2) and the secondary coil (3) of the Tesla coil generate magnetic coupling resonance; the copper cylinder (4) connected to the secondary coil breaks through the inert gas in the virtual electrode (5), forming a plasma region and generating an electromagnetic field; S3. Utilize the automatic change of the discharge area of ​​RF plasma to compensate its capacitance value to LC resonance, thereby achieving adaptive impedance matching.

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