Electronic atomized liquid and preparation method thereof

Abstract

The invention provides electronic atomized liquid and a preparation method thereof.The electronic atomized liquid comprises organic acid neotame salt, the organic acid neotame salt is dissolved in the electronic atomized liquid to release neotame, and the mass fraction of the neotame in the electronic atomized liquid is larger than 0% and smaller than or equal to 0.2% based on the total mass of the electronic atomized liquid; the electronic atomized liquid comprises at least one of fatty aldehyde acetal and a pH regulator, the mass fraction of the fatty aldehyde acetal is 0%-1% based on the total mass of the electronic atomized liquid, and the pH regulator is used for regulating the pH of the electronic atomized liquid to be 2.5-6.0. According to the embodiment of the invention, the neotame is released by using the organic acid neotame salt, the fatty aldehyde acetal is used for replacing the corresponding fatty aldehyde substance, the pH value of the electronic atomized liquid is adjusted to be acidic, and the three stabilizers are combined or combined in pairs for synergism, so that the stability of the neotame in the electronic atomized liquid is effectively improved.

Description

Technical Field

[0001] The embodiments of the present application relate to the technical field of electronic atomization liquid, and in particular, to an electronic atomization liquid and a preparation method thereof. Background Art

[0002] Sweeteners are a type of substance commonly used in electronic atomizing liquids, which can enhance the user's smoking experience and taste, and reduce the bitterness and irritation in electronic atomizing liquids. Neotame is a derivative of aspartame, a new type of dipeptide-type strong sweetener, with a chemical name of N-[N-(3,3-dimethylbutyl)-L-α-aspartate]-L-phenylalanine-1-methyl ester. It is a commonly used sweetener in electronic atomizing liquids, and its sweetness is 8,000 times that of sucrose, with the excellent characteristics of high sweetness and low energy.

[0003] However, after investigation, it was found that neotame will gradually decompose in the electronic atomization liquid system. After a period of time, the neotame content in the electronic atomization liquid dropped significantly, resulting in insufficient neotame release when the electronic atomization liquid was used, affecting the user's smoking experience. Summary of the invention

[0004] The present application aims to provide an electronic atomization liquid and a preparation method thereof, so as to solve the technical problem that the properties of the sweetener neotame are unstable when applied to the electronic atomization liquid.

[0005] In a first aspect, an embodiment of the present application provides an electronic atomization liquid, comprising:

[0006] An organic acid neotame salt, wherein the organic acid neotame salt is dissolved in the electronic atomization liquid to release neotame, so that the mass fraction of neotame in the electronic atomization liquid is greater than 0% and less than or equal to 0.2% based on the total mass of the electronic atomization liquid; and

[0007] At least one of a fatty aldehyde acetal and a pH regulator, wherein the mass fraction of the fatty aldehyde acetal is 0% to 1% based on the total mass of the electronic atomization liquid, and the pH regulator is used to adjust the pH of the electronic atomization liquid to 2.5 to 6.0.

[0008] Optionally, the organic acid neotame salt includes at least one of neotame benzoate, neotame tartrate and neotame citrate.

[0009] Optionally, the fatty aldehyde acetal includes at least one of hexanal propylene glycol acetal, isovaleraldehyde propylene glycol acetal, leaf aldehyde propylene glycol acetal, octanal propylene glycol acetal and citral diethyl acetal.

[0010] Optionally, the pH adjuster includes at least one of formic acid and triethylamine.

[0011] Optionally, the electronic atomization liquid includes the fatty aldehyde acetal, the organic acid neotame salt and the pH adjuster, wherein the mass fraction of the fatty aldehyde acetal is 1%, the neotame released by the organic acid neotame salt accounts for 0.2% of the mass fraction of the electronic atomization liquid, and the pH adjuster adjusts the pH value of the electronic atomization liquid to 4.5.

[0012] Optionally, the aliphatic aldehyde acetal is replaced by an aromatic aldehyde.

[0013] Optionally, the aromatic aldehyde includes at least one of benzaldehyde, phenylacetaldehyde, vanillin and ethyl vanillin.

[0014] In a second aspect, the present application also provides an electronic atomization liquid, comprising:

[0015] Neotame, wherein the mass fraction of the neotame in the electronic atomization liquid is greater than 0% and less than or equal to 0.2%;

[0016] Fatty aldehyde acetal, the mass fraction of the fatty aldehyde acetal in the electronic atomization liquid is greater than 0% and less than or equal to 1%; and

[0017] A pH regulator is used to adjust the pH of the electronic atomization liquid to 2.5 to 6.0.

[0018] In a third aspect, the present application also provides a method for preparing an electronic atomization liquid, comprising:

[0019] preparing a solvent, wherein the solvent comprises propylene glycol and glycerol;

[0020] Adding an organic acid neotame salt, wherein the mass fraction of neotame contained in the organic acid neotame salt is greater than 0% and less than or equal to 0.2% based on the total mass of the electronic atomization liquid;

[0021] At least one of a fatty aldehyde acetal and a pH adjuster is added, and based on the total mass of the electronic atomization liquid, the mass fraction of the fatty aldehyde acetal is 0% to 1%, and the pH adjuster is used to adjust the pH of the electronic atomization liquid to 2.5 to 6.0.

[0022] In a fourth aspect, the present application also provides a method for preparing an electronic atomization liquid, comprising:

[0023] preparing a solvent, wherein the solvent comprises propylene glycol and glycerol;

[0024] Adding neotame, wherein the mass fraction of the neotame in the electronic atomization liquid is greater than 0% and less than or equal to 0.2%;

[0025] Fatty aldehyde acetal and a pH adjuster are added, wherein the mass fraction of the fatty aldehyde acetal is greater than 0% and less than or equal to 1% based on the total mass of the electronic atomization liquid, and the pH adjuster is used to adjust the pH of the electronic atomization liquid to 2.5 to 6.0.

[0026] In the embodiment of the present application, organic acid neotame salt is used to release neotame, fatty aldehyde acetal is used to replace the corresponding fatty aldehyde substance, and the pH of the electronic atomization liquid is adjusted to acidic. The above three stabilizers are combined or combined in pairs to effectively improve the stability of neotame in the electronic atomization liquid. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for use in the description of the embodiments of the present application will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative labor.

[0028] Figure 1 A chromatographic detection diagram of neotame provided in one embodiment of the present application;

[0029] Figure 2 A schematic diagram of a method for preparing an electronic atomization liquid according to an embodiment of the present application;

[0030] Figure 3 A schematic flow chart of a method for preparing electronic atomization liquid provided in another embodiment of the present application. DETAILED DESCRIPTION

[0031] In order to make the purpose, technical solutions and advantages of the present application more clearly understood, the present application is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and are not intended to limit the present application. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in the field without making creative work are within the scope of protection of the present application.

[0032] It should be noted that, if there is no conflict, the various features in the embodiments of the present application can be combined with each other, all within the scope of protection of the present application. In addition, although the functional module division is performed in the device schematic diagram and the logical order is shown in the flow chart, in some cases, the steps shown or described can be performed in a sequence different from the module division in the device or the flow chart. Furthermore, the words "first", "second", "third", etc. used in this application do not limit the data and execution order, but only distinguish the same items or similar items with basically the same functions and effects.

[0033] First, the technical background of the electronic atomization liquid provided in the embodiments of the present application is introduced.

[0034] Neotame is widely used in pharmaceutical excipients, food additives and feed additives. With the increase in the demand for neotame, higher requirements are placed on the product quality of neotame. According to relevant literature records, the content of neotame does not change significantly under an instantaneous high temperature environment of 100°C, and neotame begins to decompose significantly after 1 hour. Specifically in electronic atomization liquid, although the heating time is short each time the electronic atomization liquid is used, due to the high frequency of use of the electronic atomization liquid, the overall heating time is longer, which causes the electronic atomization liquid to change in taste quality due to the decomposition of neotame after a certain period of use. Therefore, it is necessary to further improve the stability of neotame in the electronic atomization liquid.

[0035] The electronic atomization liquid provided in the embodiments of the present application is introduced below.

[0036] The electronic atomization liquid includes neotame and a stabilizer, wherein neotame is used as a sweetener to adjust the taste of the electronic atomization liquid. The chromatographic detection diagram of neotame is shown in FIG. Figure 1 As shown. The stabilizer is used to improve the stability of neotame in the electronic atomization liquid. Specifically, the stabilizer includes at least two of the following compounds: fatty aldehyde acetal, organic acid neotame salt and pH adjuster.

[0037] Fatty aldehyde acetals are used to replace aldehyde substances in electronic atomization liquid. Specifically, the fatty aldehyde acetal includes at least one of hexanal propylene glycol acetal, isovaleraldehyde propylene glycol acetal, leaf aldehyde propylene glycol acetal, octanal propylene glycol acetal and citral diethyl acetal. Aldehyde substances conventionally added to electronic atomization liquid include: hexanal, isovaleraldehyde, leaf aldehyde, octanal and citral. Aldehyde substances are mainly used to adjust the aroma in electronic atomization liquid. For example, electronic atomization liquid with fruit flavors such as blueberry and watermelon mainly comes from a small amount of aldehyde substances in the electronic atomization liquid. Therefore, when replacing aldehyde substances, it is also necessary to consider maintaining the aroma of the electronic atomization liquid to avoid a significant change in the flavor of the electronic atomization liquid after replacing the aldehyde substances, which may be unacceptable to users. Therefore, in order to achieve the goal of improving the stability of neotame after replacing aldehyde substances while maintaining the flavor of the electronic atomization liquid as much as possible, the corresponding aldehyde substances are usually replaced with fatty aldehyde acetals, and the mass fraction of the fatty aldehyde acetal after replacement should not exceed 1%, otherwise it is easy to cause the flavor of the electronic atomization liquid to change significantly. For electronic atomization liquids that use more aldehyde substances, some of the aldehyde substances can be replaced with corresponding fatty aldehyde acetals, and then the aldehyde substances and their fatty aldehyde acetals are used together to achieve the effect of providing flavor and improving the stability of neotame.

[0038] Specifically in this embodiment, hexanal in the original electronic atomization liquid can be replaced by hexanal propylene glycol acetal, isovaleraldehyde in the original electronic atomization liquid can be replaced by isovaleraldehyde propylene glycol acetal, leaf aldehyde in the original electronic atomization liquid can be replaced by leaf aldehyde propylene glycol acetal, octanal in the original electronic atomization liquid should be replaced by octanal propylene glycol acetal, and citral in the original electronic atomization liquid can be replaced by citral diethyl acetal.

[0039] Organic acid neotame salt is used to replace neotame in the electronic atomization liquid. Specifically, the organic acid neotame salt dissociates in the electronic atomization liquid, that is, part of the organic acid neotame salt decomposes neotame, and the rest still exists in the electronic atomization liquid as organic acid neotame salt, and the dissociation balance is maintained between the two parts. As a result, in a high temperature environment, the decomposition rate of the organic acid neotame salt of the same substance mass is slower than that of neotame, thereby improving the high temperature stability of neotame. In some embodiments, part of neotame and part of the organic acid neotame salt can be selected to be added to the electronic atomization liquid, that is, neotame and organic acid neotame salt are mixed to balance the improvement of neotame stability and reduce the cost of raw materials for the electronic atomization liquid.

[0040] The preparation method of organic acid neotame salt can refer to the following example: neotame and organic acid are weighed in a molar ratio of 1:1, neotame is first added to an ethanol solution and stirred for dispersion, the temperature is raised to 50°C to dissolve the neotame, then the organic acid is added, stirring is continued for 2 hours, then an appropriate amount of water is added to keep the solution system in a clear state, and white organic acid neotame salt is obtained by freeze drying and recovery. The above organic acid is selected from one of benzoic acid, tartaric acid and citric acid.

[0041] The pH regulator is used to adjust the pH of the electronic atomization liquid to improve the stability of neotame in the electronic atomization liquid. Specifically, the conventional pH value of the electronic atomization liquid ranges from 4 to 7, and it fluctuates within this range according to the components of different electronic atomization liquids. When the pH value exceeds this range, it may have an adverse effect on other components in the electronic atomization liquid. For example, when the pH is too high, it will reduce the release of nicotine in the electronic atomization liquid. Specifically in this embodiment, the pH regulator can be selected from at least one of formic acid and triethylamine, wherein formic acid is an acidic regulator and triethylamine is an alkaline regulator. It should be noted that the selection of a specific pH regulator can be selected according to different electronic atomization liquid composition systems, and is not limited to the formic acid and triethylamine described in this embodiment.

[0042] The embodiment of the present application uses a liquid chromatograph-diode array detector (HPLC-DAD) to determine the change in the content of neotame in the electronic atomization liquid, and the change in the content of neotame is used to evaluate the stability of neotame. Specifically in this embodiment, the detection chromatographic conditions include: the chromatographic column selects Agilent HC-C18, the specification is 4.6×250mm, 5μm; the column temperature is set to 30°C; the injection volume is set to 5μL each time; the mobile phase includes phase A and phase B, and phase A uses an ion pair reagent, specifically 2.00g sodium octane sulfonate is added to 500mL ultrapure water to dissolve, and then 1.0mL phosphoric acid is added and ultrapure water is added to make up to 1000mL and shaken to prepare, and phase B uses acetonitrile solution; the flow rate of the mobile phase is set to 1mL / min; the detection wavelength of the diode array detector is set to 218nm.

[0043] The following are descriptions of the embodiments and comparative examples of the electronic atomization liquid described in the present application.

[0044] Examples 1 to 6 and Comparative Example 1 are used to illustrate the effect of adjusting the pH value of the electronic atomization liquid on the stability of neotame.

[0045] Example 1

[0046] Specifically, a method for preparing an electronic atomization liquid comprises the following steps:

[0047] S21, providing a solvent, wherein the solvent includes propylene glycol and glycerol, and the mass ratio of propylene glycol to glycerol is 1:1;

[0048] S22, adding 0.2% by mass of neotame as a sweetener, 1.7% by mass of nicotine benzoate salt, and 2% by mass of a cooling agent, and supplementing to 100% with a propylene glycol and glycerin solvent in a mass ratio of 1:1;

[0049] S23. Then, the pH value of the electronic atomization liquid is adjusted to 2.5 by adding formic acid, a pH adjuster.

[0050] An electronic atomization liquid is obtained, and then the electronic atomization liquid is placed in a room temperature environment (25°C) for storage, and the content of neotame in the electronic atomization liquid is measured at the detection time point (for example, day 0, day 7, day 14, day 30, day 60, day 90, etc.), and the neotame retention rate in the subsequent time period is calculated based on the theoretical content of neotame (actual amount of neotame added). Specifically, the calculation of the neotame retention rate can be exemplarily referred to the following formula:

[0051]

[0052] Among them, X1 is the measured content of neotame in the electronic atomization liquid sample, in %; C is the concentration of the electronic atomization liquid sample measured on the machine, in mg / L; V is the fixed volume of the electronic atomization liquid sample during measurement, in mL; m is the sample weight during measurement of the electronic atomization liquid sample, in g; X2 is the theoretical content of neotame in the electronic atomization liquid sample, in %; m1 is the sample weight during preparation of the electronic atomization liquid sample, in g; M is the total mass of the electronic atomization liquid sample during preparation, in g.

[0053] Take out the electronic atomization liquid sample at the detection time point, weigh 0.2g each time using a 1 / 10,000 balance, add 9.8mL of formic acid-triethylamine mixed extract and shake for 20 minutes, then filter the solution with a 0.45μm water filter membrane to obtain the filtrate as the sample solution to be tested.

[0054] Before testing the sample solution to be tested, a neotame standard solution needs to be prepared. The standard solution is prepared with a formic acid-triethylamine mixed extract to prepare a neotame standard solution with a linear range of 1 to 100 mg / L, and a standard curve is established using the external standard method to quantitatively detect the neotame content in the sample solution to be tested. The specific detection method is as described above and will not be repeated here. It should be noted that the elution program in Example 1 is set to gradient elution. Specifically in this embodiment, it is set as follows according to Table 1:

[0055] Table 1 Mobile phase elution program

[0056]

[0057]

[0058] By continuously changing the concentration ratio of the mobile phase according to a certain procedure in the same analysis cycle, changing the proportion of each solvent composition in the mobile phase and changing the polarity of the mobile phase, each effluent component has a suitable capacity factor and all components in the sample can achieve the best separation effect in a short time.

[0059] Example 2

[0060] The difference between Example 2 and Example 1 is that the pH value of the electronic atomization liquid is adjusted to 4.5, and the other conditions are the same as those of Example 1.

[0061] Example 3

[0062] The difference between Example 3 and Example 1 is that the pH value of the electronic atomization liquid is adjusted to 5.5, and the other conditions are the same as those of Example 1.

[0063] Example 4

[0064] The difference between Example 4 and Example 1 is that the pH regulator of the electronic atomization liquid is triethylamine, the pH value is adjusted to 7.0, and the other conditions are the same as those in Example 1.

[0065] Example 5

[0066] The difference between Example 5 and Example 1 is that the pH regulator of the electronic atomization liquid is triethylamine, the pH value is adjusted to 8.5, and the other conditions are the same as those in Example 1.

[0067] Example 6

[0068] The difference between Example 6 and Example 1 is that the pH regulator of the electronic atomization liquid is triethylamine, the pH value is adjusted to 10.5, and the other conditions are the same as those in Example 1.

[0069] Comparative Example 1

[0070] The difference between Comparative Example 1 and Example 1 is that no pH adjuster is added to adjust the pH value of the electronic atomization liquid, and other conditions are the same as those of Example 1. It should be noted that the pH value of the electronic atomization liquid sample used in Comparative Example 1 is 6.1.

[0071] The experimental results of Examples 1 to 6 and Comparative Example 1 are shown in Table 2 below.

[0072] Table 2 Effect of different pH on the stability of neotame in electronic atomization liquid

[0073]

[0074]

[0075] As can be seen from the above table, with the change of time, the content of neotame in the electronic atomization liquid gradually decreases. Under acidic pH conditions (i.e., in the embodiments of pH = 2.5, 4.5, and 5.5), the retention rate of neotame after 90 days at room temperature is above 77%, of which the retention rate can reach 86% at pH = 2.5 and 4.5, indicating that its stability is relatively good. Under alkaline pH conditions (i.e., in the embodiments of pH = 8.5 and 10.5), the retention rate of neotame after 90 days is less than 10%, which also shows that neotame is easy to decompose under alkaline conditions. Referring to the case where the pH is not adjusted (i.e., Comparative Example 1), the retention rate of neotame after 90 days is slightly higher than the retention rate under neutral pH conditions for 90 days, and slightly lower than the retention rate of neotame under acidic conditions (Example 3), which also shows that the pH value of conventional electronic atomization liquid is usually acidic, and further confirms that acidic conditions help to improve the stability of neotame.

[0076] Examples 7 to 9 and Comparative Example 2 are used to illustrate the effect of replacing neotame in the electronic atomization liquid with an organic acid neotame salt on the stability of neotame.

[0077] Example 7

[0078] The difference between Example 7 and Comparative Example 1 is that when preparing the electronic atomization liquid, neotame benzoate is added to replace neotame (ie, no neotame is added), and the mass percentage of neotame in the neotame benzoate accounts for 0.2% of the total mass of the electronic atomization liquid.

[0079] It should be noted that in Examples 7 to 9 and Comparative Example 2, in order to quickly observe the changes in the neotame content, the prepared electronic atomization liquid was placed under accelerated conditions (i.e., a constant temperature and humidity chamber with a temperature of 40°C and a humidity of 70%) for observation, and the neotame content in the electronic atomization liquid was measured on the 0th day, the 7th day, the 14th day, the 30th day, the 60th day, and the 90th day, respectively. The theoretical addition value of neotame was used as the initial value, and the neotame retention rate in the subsequent time was calculated.

[0080] In Example 7, since a new component is introduced by replacing neotame, it may affect the atomization and the taste of the electronic atomization liquid. Therefore, in addition to detecting the change in the neotame content to evaluate the stability of neotame, it is also necessary to evaluate the effect of the introduction of organic acid neotame salt on the atomization and the taste of the electronic atomization liquid.

[0081] Specifically, in Example 7, a neotame atomization rate test is also included. For example, a mixture of propylene glycol and glycerol in a mass ratio of 1:1 is used as a solvent, and organic acid neotame salts (neotame benzoate, neotame tartrate, and neotame citrate in Examples 7, 8, and 9, respectively) are added to prepare a solution with a neotame content of 0.2% as an electronic atomization liquid. The prepared electronic atomization liquid is poured into the atomization device and connected to the smoking machine for suction. A Cambridge filter is set at the other end of the suction pipeline to capture the aerosol generated by the atomization device, which is used to determine the content of neotame in the electronic atomization liquid and the aerosol, thereby calculating the atomization rate. The calculation of the atomization rate can be exemplified by referring to the following formula

[0082]

[0083] Among them, X1 is the measured content of neotame in the electronic atomization liquid sample, in mg / g; C1 is the concentration of the electronic atomization liquid sample measured on the machine, in mg / L; V1 is the fixed volume when the electronic atomization liquid sample is measured, in mL; m1 is the sample weight when the electronic atomization liquid sample is measured, in g; X2 is the measured content of neotame in the aerosol sample, in mg / g; C2 is the concentration of the aerosol sample measured on the machine, in mg / L; V2 is the fixed volume when the aerosol sample is measured, in mL; TPM is the weight change value of the Cambridge filter before and after suction, in g.

[0084] It should be noted that the content of neotame in the electronic atomization liquid can be detected by referring to the following exemplary operation: 0.2 g of the electronic atomization liquid is weighed with a 1 / 10,000 balance, methanol solution is added to make the volume to 10 mL, and after oscillation extraction for 20 minutes, the solution is filtered through a 0.45 μm organic filter membrane into a 2 mL automatic injection bottle for liquid chromatography-diode array detection.

[0085] The content of neotame in the aerosol can be detected by referring to the following exemplary operation: smoke with a smoking machine, the puffing volume is set to 55 mL, the puffing time is set to 3S, the interval time is set to 27S, the number of puffs is set to 100 times, and the weight change value (TPM) of the Cambridge filter before and after the puffing is recorded. After the puffing is completed, the Cambridge filter is placed in a 50 mL centrifuge tube, 20 mL of methanol solution is added, and the oscillation extraction is performed for 20 minutes. The solution is filtered through a 0.45 μm organic filter membrane into a 2 mL automatic injection bottle for liquid chromatography-diode array detection. The specific liquid chromatography conditions are as described above and will not be repeated here.

[0086] Example 8

[0087] The difference between Example 8 and Example 7 is that the sweetener in the electronic atomization liquid is neotame tartrate, and the other conditions are the same as those in Example 7.

[0088] Example 9

[0089] The difference between Example 9 and Example 7 is that the sweetener in the electronic atomization liquid is neotame citrate, and the other conditions are the same as those in Example 7.

[0090] Comparative Example 2

[0091] The difference between Comparative Example 2 and Example 7 is that the sweetener in the electronic atomization liquid is 0.2% by mass of neotame (ie, organic acid neotame salt is not used to replace neotame), and the other conditions are the same as those in Example 7.

[0092] For Example 7, Example 8, Example 9 and Comparative Example 2, a sensory evaluation of the electronic atomization liquid is also included. Specifically, the corresponding electronic atomization liquid is poured into the atomizing device, and the sensory evaluation team members perform suction evaluation. The sensory evaluation team consists of 10 professional evaluators with more than 5 years of experience in the industry. They taste and score the electronic atomization liquid samples, and evaluate them from 6 dimensions: sweetness of taste, speed of feeling sweetness, time of feeling sweetness, whether there is obvious sweetness residue, whether there is peculiar smell, and whether the overall sweetness is coordinated. The scoring standard is 1 to 5 points, 5 points are the best, and the full score is 30 points. The total score removes the highest and lowest scores, and the average is taken as the sensory evaluation score. The experimental results of Examples 7 to 9 and Comparative Example 2 are shown in Table 3 below.

[0093] Table 3 Effects of different organic acid neotame salts on neotame stability, atomization rate and sensory evaluation in electronic atomization liquid

[0094]

[0095] As can be seen from Table 3, under accelerated conditions (i.e., temperature 40°C, humidity 70%), the retention rate of organic acid neotame salt within 90 days is above 49%; compared with the results of normal use of neotame in Comparative Example 2, the neotame retention rate within 90 days is only about 2%. This shows that the use of organic acid neotame salt instead of neotame can effectively improve the stability of neotame in electronic atomization liquid. Among the three groups of conditions in Examples 7, 8, and 9, the atomization rate of neotame benzoate salt is the highest, that is, the sweetness release is high. Compared with Comparative Example 2, there is no significant difference in the atomization rate results of neotame benzoate salt and neotame, while the atomization rates of the other groups of organic acid neotame salts have all shown significant attenuation. In terms of sensory evaluation, neotame benzoate salt has the highest sensory score. Compared with Comparative Example 2, the scores of neotame benzoate salt and neotame are basically the same, indicating that the use of neotame benzoate salt instead of neotame does not basically affect the flavor quality of the atomized liquid.

[0096] Examples 10 to 14 and Comparative Examples 3 to 12 are used to illustrate the effect of using acetals instead of aldehydes in the electronic atomization liquid as aroma substances on the stability of neotame.

[0097] Example 10

[0098] The difference between Example 10 and Comparative Example 1 is that the electronic atomization liquid also includes the aroma substance hexanal propylene glycol acetal; at the same time, the effects of different contents of hexanal propylene glycol acetal on the stability of neotame in the electronic atomization liquid are compared. The contents of hexanal propylene glycol acetal are 0.05%, 0.1%, 0.2%, 0.5%, and 1%, respectively; the other conditions are the same as those in Example 10.

[0099] Embodiment 11

[0100] The difference between Example 11 and Comparative Example 1 is that the electronic atomization liquid also includes the aroma substance isovaleraldehyde propylene glycol acetal; at the same time, the effect of different contents of isovaleraldehyde propylene glycol acetal on the stability of neotame in the electronic atomization liquid is compared. The contents of isovaleraldehyde propylene glycol acetal are 0.05%, 0.1%, 0.2%, 0.5%, and 1% respectively; the other conditions are the same as those in Example 10.

[0101] Example 12

[0102] The difference between Example 12 and Comparative Example 1 is that the electronic atomization liquid also includes the aroma substance isovaleraldehyde propylene glycol acetal; at the same time, the effects of different contents of leaf aldehyde propylene glycol acetal on the stability of neotame in the electronic atomization liquid are compared. The contents of leaf aldehyde propylene glycol acetal are 0.05%, 0.1%, 0.2%, 0.5%, and 1% respectively; the other conditions are the same as those in Example 10.

[0103] Embodiment 13

[0104] The difference between Example 13 and Comparative Example 1 is that the electronic atomization liquid also includes the aroma substance octanal propylene glycol acetal; at the same time, the effects of different contents of octanal propylene glycol acetal on the stability of neotame in the electronic atomization liquid are compared. The contents of octanal propylene glycol acetal are 0.05%, 0.1%, 0.2%, 0.5%, and 1% respectively; the other conditions are the same as those in Example 10.

[0105] Embodiment 14

[0106] The difference between Example 14 and Comparative Example 1 is that the electronic atomization liquid also includes the aroma substance citral diethyl acetal; at the same time, the effects of different contents of citral diethyl acetal on the stability of neotame in the electronic atomization liquid are compared. The contents of citral diethyl acetal are 0.05%, 0.1%, 0.2%, 0.5%, and 1% respectively; the other conditions are the same as those in Example 10.

[0107] Comparative Example 3

[0108] The difference between Comparative Example 3 and Example 10 is that the aroma substance in the electronic atomization liquid is hexanal; at the same time, the effects of different contents of hexanal on the stability of neotame in the electronic atomization liquid are compared. The contents of hexanal are 0.05%, 0.1%, 0.2%, 0.5%, and 1%, respectively; the other conditions are the same as those in Example 10.

[0109] Comparative Example 4

[0110] The difference between Comparative Example 4 and Example 11 is that the aroma substance in the electronic atomization liquid is isovaleraldehyde; at the same time, the effects of different contents of isovaleraldehyde on the stability of neotame in the electronic atomization liquid are compared. The contents of isovaleraldehyde are 0.05%, 0.1%, 0.2%, 0.5%, and 1%, respectively; the other conditions are the same as those in Example 10.

[0111] Comparative Example 5

[0112] The difference between Comparative Example 5 and Example 12 is that the aroma substance in the electronic atomization liquid is folialdehyde; at the same time, the effects of different folialdehyde contents on the stability of neotame in the electronic atomization liquid are compared. The folialdehyde contents are 0.05%, 0.1%, 0.2%, 0.5%, and 1%, respectively; the other conditions are the same as those in Example 10.

[0113] Comparative Example 6

[0114] The difference between Comparative Example 6 and Example 13 is that the aroma substance in the electronic atomization liquid is octanal; at the same time, the effects of different contents of octanal on the stability of neotame in the electronic atomization liquid are compared. The contents of octanal are 0.05%, 0.1%, 0.2%, 0.5%, and 1% respectively; the other conditions are the same as those in Example 10.

[0115] Comparative Example 7

[0116] The difference between Comparative Example 7 and Example 14 is that the aroma substance in the electronic atomization liquid is citral; at the same time, the effects of different contents of citral on the stability of neotame in the electronic atomization liquid are compared. The contents of citral are 0.05%, 0.1%, 0.2%, 0.5%, and 1% respectively; the other conditions are the same as those in Example 10.

[0117] Comparative Example 8

[0118] The difference between Comparative Example 8 and Example 10 is that the aroma substance in the electronic atomization liquid is benzaldehyde; at the same time, the effects of different contents of benzaldehyde on the stability of neotame in the electronic atomization liquid are compared. The contents of benzaldehyde are 0.05%, 0.1%, 0.2%, 0.5%, and 1% respectively; the other conditions are the same as those in Example 10.

[0119] Comparative Example 9

[0120] The difference between Comparative Example 9 and Example 10 is that the aroma substance in the electronic atomization liquid is phenylacetaldehyde; at the same time, the effects of different contents of phenylacetaldehyde on the stability of neotame in the electronic atomization liquid are compared. The contents of phenylacetaldehyde are 0.05%, 0.1%, 0.2%, 0.5%, and 1% respectively; the other conditions are the same as those in Example 10.

[0121] Comparative Example 10

[0122] The difference between Comparative Example 10 and Example 10 is that the aroma substance in the electronic atomization liquid is vanillin; at the same time, the effects of different contents of vanillin on the stability of neotame in the electronic atomization liquid are compared. The contents of vanillin are 0.05%, 0.1%, 0.2%, 0.5%, and 1% respectively; the other conditions are the same as those in Example 10.

[0123] Comparative Example 11

[0124] The difference between Comparative Example 11 and Example 10 is that the aroma substance in the electronic atomization liquid is ethyl vanillin; at the same time, the effects of different contents of ethyl vanillin on the stability of neotame in the electronic atomization liquid are compared. The contents of ethyl vanillin are 0.05%, 0.1%, 0.2%, 0.5%, and 1% respectively; the other conditions are the same as those in Example 10.

[0125] It should be noted that in Examples 10 to 14 and Comparative Examples 3 to 11, the prepared electronic atomization liquid was placed at room temperature (usually 25°C) for observation, and the content of neotame in the electronic atomization liquid was measured on the 0th day, the 7th day, the 14th day, the 21st day, and the 28th day, respectively, and the theoretical addition value of neotame was used as the initial value to calculate the neotame retention rate in the subsequent time. The experimental results of Examples 10 to 14 and Comparative Examples 3 to 12 are shown in Table 4 below.

[0126] Table 4 Effects of different aldehydes on the stability of neotame in electronic atomization liquid

[0127]

[0128]

[0129]

[0130]

[0131] As shown in Table 4, if no aldehydes are added to the electronic atomization liquid, the retention rate of neotame is still 92.37% after 28 days, that is, the natural decomposition rate of neotame is slow in an environment without aldehydes. Compared with the control group with different concentrations of fatty aldehydes (hexanal, isovaleraldehyde, leaf aldehyde, octanal, citral), the retention rate of neotame after 28 days is lower than this value, which can be explained that fatty aldehydes accelerate the decomposition of neotame; and with the increase of the amount of fatty aldehydes added, neotame drops rapidly from 0 to 21 days, and the retention rate of neotame decreases significantly, which further illustrates that the presence of fatty aldehydes has a greater negative impact on the stability of neotame.

[0132] In contrast, in Examples 10 to 14, the use of the same concentration of fatty aldehyde acetals (hexanal propylene glycol acetal, isovaleraldehyde propylene glycol acetal, leaf aldehyde propylene glycol acetal, octanal propylene glycol acetal, citral diethyl acetal) instead of the corresponding fatty aldehydes can significantly improve the neotame retention rate, especially when a high concentration of fatty aldehyde acetals is added (the added mass is 1%). After 28 days, the neotame retention rate of the corresponding experimental group is basically above 90%, while the neotame retention rate in the electronic atomization liquid with the addition of fatty aldehydes is basically around 30% to 60%.

[0133] Among them, only the neotame retention rate of leaf aldehyde propanediol acetal and citral diethyl acetal decreased with the increase of acetal addition mass. When the added mass was 0.5% and 1%, the neotame retention rate at 28 days was less than 90%, but it was still better than the neotame retention rate of the corresponding fatty aldehyde at the same mass. This shows that the use of fatty aldehyde acetals instead of fatty aldehydes can effectively improve the stability of neotame in electronic atomization liquid, and also shows that different types of fatty aldehyde acetals have different effects on improving the stability of neotame. Among them, hexanal propanediol acetal, isovaleraldehyde propanediol acetal, and octanal propanediol acetal have better effects on improving the stability of neotame, while leaf aldehyde propanediol acetal and citral diethyl acetal have poor effects on improving the stability of neotame.

[0134] In Comparative Examples 8 to 12, aromatic aldehydes (benzaldehyde, phenylacetaldehyde, vanillin, ethyl vanillin) were added to the electronic atomization liquid. 4 It can be seen that the addition of aromatic aldehydes has no significant effect on the decrease in neotame retention rate, and the content of aromatic aldehydes has no significant effect on the decrease in neotame retention rate. At 28 days, the neotame retention rate is close to that of the sample without any aldehydes added, and the retention rate is above 90%. This shows that aromatic aldehydes have almost no negative impact on the stability of neotame and can protect the stability of neotame to a certain extent.

[0135] Examples 15 to 18 and Comparative Examples 12 to 17 are used to illustrate the synergistic effect of pH adjusters, fatty aldehyde acetals and organic acid neotame salts on the stability of neotame after combination.

[0136] Embodiment 15

[0137] The difference between Example 15 and Comparative Example 1 is that the electronic atomization liquid contains 0.2% of neotame benzoate and 1% of hexanal propylene glycol acetal, and the pH is adjusted to 4.5.

[0138] Example 16

[0139] The difference between Example 16 and Example 15 is that the electronic atomization liquid contains 0.2% neotame benzoate and 1% hexanal propylene glycol acetal, and no pH adjustment is performed.

[0140] Embodiment 17

[0141] The difference between Example 17 and Example 15 is that the electronic atomization liquid includes 0.2% neotame benzoate, the pH is adjusted to 4.5, and the other conditions are the same as those of Example 15.

[0142] Embodiment 18

[0143] The difference between Example 18 and Example 15 is that the electronic atomization liquid includes 0.2% neotame and 1% hexanal propylene glycol acetal, the pH is adjusted to 4.5, and the other conditions are the same as those in Example 15.

[0144] Comparative Example 12

[0145] The difference between Comparative Example 12 and Example 15 is that the electronic atomization liquid includes 0.2% neotame tartrate and 1% hexanal, the pH is adjusted to 7, and the other conditions are the same as those in Example 15.

[0146] Comparative Example 13

[0147] The difference between Comparative Example 13 and Example 15 is that the electronic atomization liquid includes 0.2% neotame tartrate and 1% hexanal, no pH adjustment is performed, and the other conditions are the same as those in Example 15.

[0148] Comparative Example 14

[0149] The difference between Comparative Example 14 and Example 15 is that the electronic atomization liquid includes 0.2% neotame tartrate, the pH is adjusted to 7, and the other conditions are the same as those of Example 15.

[0150] Comparative Example 15

[0151] The difference between Comparative Example 15 and Example 15 is that the electronic atomization liquid includes 0.2% neotame and 1% hexanal, the pH is adjusted to 7, and the other conditions are the same as those of Example 15.

[0152] Comparative Example 16

[0153] The difference between Comparative Example 16 and Example 15 is that the electronic atomization liquid includes 0.2% neotame and 1% hexanal propylene glycol acetal, the pH is adjusted to 7, and the other conditions are the same as those in Example 15.

[0154] Comparative Example 17

[0155] The difference between Comparative Example 17 and Example 15 is that the electronic atomization liquid includes 0.2% neotame and the pH is not adjusted to 7, and the other conditions are the same as those in Example 15.

[0156] It should be noted that in Examples 15 to 18 and Comparative Examples 12 to 17, in order to quickly observe the changes in the neotame content, the above solution was placed under accelerated conditions (i.e., a constant temperature and humidity chamber with a temperature of 40°C and a humidity of 70%), and the content of neotame in the electronic atomization liquid was determined on the 0th day, the 1st day, the 3rd day, the 5th day, the 6th day, the 7th day, and the 10th day, respectively. The theoretical addition value of neotame was used as the initial value to calculate the neotame retention rate in the subsequent time. Specifically in this embodiment, according to the data comparison, the neotame retention rate on the 7th day under accelerated conditions is approximately equal to the neotame retention rate on the 30th day under room temperature. The experimental results of Examples 15 to 18 and Comparative Examples 12 to 17 are shown in Table 5 below.

[0157] Table 5 Effects of different combinations of conditions on the stability of neotame

[0158]

[0159]

[0160] As can be seen from Table 5 above, taking neotame (no aroma substances added, no pH adjustment) as the control, the neotame retention rate on the 10th day under accelerated conditions (temperature 40°C, humidity 70%) is 87.70%; if the pH is adjusted to 4.5, or neotame benzoate is used instead of neotame, or 1% fatty aldehyde acetal is added, when these three conditions are combined at the same time or in pairs, the neotame retention rate on the 10th day is greater than 87.70%. This shows that when the three conditions are combined or combined in pairs, they all help to improve the stability of neotame in the electronic atomization liquid, rather than producing a negative synergistic reaction.

[0161] When pH regulator is added to adjust pH to 7.0, or tartaric acid neotame salt is used to replace neotame, or 1% fatty aldehyde is added, when these three conditions are combined at the same time or in pairs, the neotame retention rate on the 10th day is less than 87.70%, and according to the neotame retention rate results, the pH is adjusted to 7.0 compared with the experimental group without pH adjustment. The neotame retention rate decreases the most, followed by the addition of fatty aldehydes, and finally the replacement of neotame with organic acid neotame salt. This also shows that the pH adjustment to 7.0 has the greatest effect on the stability of neotame, followed by the effect of fatty aldehydes on the stability of neotame, and finally the use of organic acid neotame salt to replace neotame has the least effect on the stability of neotame.

[0162] The following describes the preparation method of the electronic atomization liquid in the embodiment of the present application. Figure 2 , Figure 2 A schematic flow chart of a method for preparing an electronic atomization liquid provided in an embodiment of the present application includes:

[0163] S21. Provide a solvent, wherein the solvent includes propylene glycol and glycerin.

[0164] S22. Adding organic acid neotame salt, wherein the organic acid neotame salt is dissolved in the electronic atomization liquid to release neotame, so that the mass fraction of neotame in the electronic atomization liquid is greater than 0% and less than or equal to 0.2% based on the total mass of the electronic atomization liquid.

[0165] S23. Add at least one of fatty aldehyde acetal and pH adjuster. Based on the total mass of the electronic atomization liquid, the mass fraction of the fatty aldehyde acetal is 0% to 1%, and the pH adjuster is used to adjust the pH of the electronic atomization liquid to 2.5 to 6.

[0166] See also Figure 3 , Figure 3A schematic flow chart of a method for preparing an electronic atomization liquid provided in another embodiment of the present application includes:

[0167] S31. Provide a solvent, wherein the solvent includes propylene glycol and glycerin.

[0168] S32, adding neotame, wherein the mass fraction of neotame in the electronic atomization liquid is greater than 0% and less than or equal to 0.2%.

[0169] S33. Add fatty aldehyde acetal and pH adjuster. Based on the total mass of the electronic atomization liquid, the mass fraction of the fatty aldehyde acetal is greater than 0% and less than or equal to 1%. The pH adjuster is used to adjust the pH of the electronic atomization liquid to 2.5 to 6.

[0170] In summary, the electronic atomization liquid provided in the embodiment of the present application, by adjusting the pH of the smoke liquid atomization liquid, proves that when placed at room temperature for 90 days, the retention rate of neotame in an acidic pH environment is above 77%, and the retention rate in an alkaline pH environment is less than 10%, and the retention rate of the sample without adjusting the pH is 74.39%, indicating that adjusting the pH of the smoke liquid atomization liquid to acidity can improve the stability of the sweetener neotame. At the same time, by using organic acid neotame salt instead of neotame, the organic acid neotame salt is preferably benzoic acid neotame salt, and when placed under accelerated conditions for 90 days, the retention rate of the organic acid neotame salt is above 49%, while the retention rate of the normal addition of neotame is only about 2%. Among them, the atomization rate results and sensory evaluation scores of benzoic acid neotame and neotame are basically consistent, indicating that the organic acid neotame salt can replace neotame to improve the stability of the sweetener neotame without affecting the flavor quality of the atomized liquid. The present application also replaces the aldehyde substances in the electronic atomization liquid with acetals, preferably using fatty aldehyde acetals instead of fatty aldehydes. The retention rate after being placed at room temperature for 28 days is higher than the retention rate of neotame with added fatty aldehydes, and the retention rate is basically above 90%. This shows that replacing fatty aldehydes with fatty aldehyde acetals can effectively alleviate the decrease in neotame content and can effectively improve the stability of the sweetener neotame.

[0171] Finally, by adjusting the pH of the electronic atomization liquid to acidic, replacing neotame with organic acid neotame salt, and using acetals to replace aldehyde substances in the electronic atomization liquid, or combining them in pairs, the retention rate at 10 days under accelerated conditions was higher than the neotame retention rate when no acetals and aldehydes were added, the pH was not adjusted, and only neotame was added, indicating that the synergistic effect of the three combinations can further improve the stability of the sweetener neotame.

[0172] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present disclosure, rather than to limit them. Under the concept of the present disclosure, the technical features in the above embodiments or different embodiments may also be combined, the steps may be implemented in any order, and there are many other changes in different aspects of the present disclosure as described above, which are not provided in detail for the sake of simplicity. Although the present disclosure has been described in detail with reference to the aforementioned embodiments, a person of ordinary skill in the art should understand that the technical solutions described in the aforementioned embodiments may still be modified, or some of the technical features may be replaced by equivalents. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the scope of the technical solutions of the embodiments of the present disclosure.

Claims

1. An electronic atomization liquid, characterized in that: include: An organic acid neotame salt, wherein the organic acid neotame salt is dissolved in the electronic atomization liquid to release neotame, so that the mass fraction of neotame in the electronic atomization liquid is greater than 0% and less than or equal to 0.2% based on the total mass of the electronic atomization liquid; and At least one of a fatty aldehyde acetal and a pH regulator, wherein the mass fraction of the fatty aldehyde acetal is 0% to 1% based on the total mass of the electronic atomization liquid, and the pH regulator is used to adjust the pH of the electronic atomization liquid to 2.5 to 6.

0.

2. The electronic atomization liquid according to claim 1, characterized in that: The organic acid neotame salt includes at least one of neotame benzoate, neotame tartrate and neotame citrate.

3. The electronic atomization liquid according to claim 1, characterized in that: The fatty aldehyde acetal includes at least one of hexanal propylene glycol acetal, isovaleraldehyde propylene glycol acetal, leaf aldehyde propylene glycol acetal, octanal propylene glycol acetal and citral diethyl acetal.

4. The electronic atomization liquid according to claim 1, characterized in that: The pH adjuster includes at least one of formic acid and triethylamine.

5. The electronic atomization liquid according to any one of claims 1 to 4, characterized in that: The electronic atomization liquid includes the fatty aldehyde acetal, the organic acid neotame salt and the pH adjuster, wherein the mass fraction of the fatty aldehyde acetal is 1%, the neotame released by the organic acid neotame salt accounts for 0.2% of the mass fraction of the electronic atomization liquid, and the pH adjuster adjusts the pH value of the electronic atomization liquid to 4.

5.

6. The electronic atomization liquid according to claim 1, characterized in that: The aliphatic aldehyde acetal is replaced by an aromatic aldehyde.

7. The electronic atomization liquid according to claim 6, characterized in that: The aromatic aldehyde includes at least one of benzaldehyde, phenylacetaldehyde, vanillin and ethyl vanillin.

8. An electronic atomization liquid, characterized in that: include: Neotame, wherein the mass fraction of the neotame in the electronic atomization liquid is greater than 0% and less than or equal to 0.2%; Fatty aldehyde acetal, the mass fraction of the fatty aldehyde acetal in the electronic atomization liquid is greater than 0% and less than or equal to 1%; and A pH regulator is used to adjust the pH of the electronic atomization liquid to 2.5 to 6.

0.

9. The method for preparing the electronic atomization liquid according to any one of claims 1 to 7, characterized in that: include: preparing a solvent, wherein the solvent comprises propylene glycol and glycerol; Adding an organic acid neotame salt, wherein the organic acid neotame salt is dissolved in the solvent to release neotame, so that the mass fraction of neotame in the electronic atomization liquid is greater than 0% and less than or equal to 0.2% based on the total mass of the electronic atomization liquid; At least one of a fatty aldehyde acetal and a pH adjuster is added, and based on the total mass of the electronic atomization liquid, the mass fraction of the fatty aldehyde acetal is 0% to 1%, and the pH adjuster is used to adjust the pH of the electronic atomization liquid to 2.5 to 6.

0.

10. The method for preparing the electronic atomization liquid according to claim 8, characterized in that: include: preparing a solvent, wherein the solvent comprises propylene glycol and glycerol; Adding neotame, wherein the mass fraction of the neotame in the electronic atomization liquid is greater than 0% and less than or equal to 0.2%; Fatty aldehyde acetal and a pH adjuster are added, wherein the mass fraction of the fatty aldehyde acetal is greater than 0% and less than or equal to 1% based on the total mass of the electronic atomization liquid, and the pH adjuster is used to adjust the pH of the electronic atomization liquid to 2.5 to 6.0.

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