Externally applied medicine for whelks and preparation method of externally applied medicine

Abstract

The invention relates to an external acne medicine and a preparation method thereof, and belongs to the technical field of external traditional Chinese medicine preparations. The externally applied medicine comprises disinfectant, powder and externally applied paste, and through the synergistic effect of the three components, the comprehensive treatment effects of sterilization and disinfection, heat clearing and detoxifying and tissue repair are achieved. The disinfectant takes scorpions, centipedes, snakes, blister beetles, spiders and white spirit as main raw materials, and has a powerful sterilization function; the powder consists of dried alum, salix leaves, xanthium sibiricum leaves and salt, and can clear away heat and toxic materials, diminish inflammation and relieve itching; the external ointment is combined with multiple traditional Chinese medicinal materials such as beeswax, radix paeoniae rubra and radix angelicae sinensis, wound healing can be promoted, and no scar is left. The externally applied medicine is suitable for various whelk patients including diabetic patients, and the problem of chronic wound healing is remarkably solved. The invention further provides a detailed preparation process. The externally applied medicine has the advantages of remarkable curative effect, high safety, difficulty in relapse, convenience in use and the like, and can be widely applied to treatment and nursing of acne.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine external preparations, and in particular to an external medicine for acne and a preparation method thereof. Background Art

[0002] Acne is the most common chronic inflammatory disease in dermatology, usually occurring in the sebaceous follicles. Its formation mechanism is complex and is closely related to endocrine disorders, excessive sebum secretion, abnormal keratinization of hair follicles, bacterial infection (such as Propionibacterium acnes), as well as genetic, dietary and environmental factors. Acne often occurs on the face, back and chest, which not only affects the patient's appearance, but may also cause serious psychological burden and reduce the patient's quality of life.

[0003] The current treatments for acne mainly include the following categories:

[0004] Oral antibiotics: Commonly used antibiotics such as tetracycline and erythromycin reduce inflammation by inhibiting bacterial infection. However, long-term use of antibiotics can easily lead to the emergence of drug-resistant strains and may cause systemic side effects such as gastrointestinal discomfort.

[0005] Retinoic acid drugs: These drugs reduce the blockage of hair follicles by regulating the differentiation of keratinocytes. However, topical retinoic acid often causes irritation reactions such as dry skin, erythema, and desquamation, and patient compliance is poor; oral retinoic acid may affect the liver and reproductive system, and its use is limited.

[0006] Hormone drugs: Mainly used for patients with severe inflammation, but long-term use of hormones may cause side effects such as skin atrophy and capillary dilation, and are prone to relapse after discontinuation of the drug.

[0007] Physical therapy: such as laser and photodynamic therapy, although effective in some cases, is expensive and has limited efficacy for patients with severe or recurrent acne.

[0008] Chinese herbal medicine preparations: In recent years, Chinese herbal medicine preparations for external use based on the theory of traditional Chinese medicine have gradually attracted attention. This type of medicine is widely accepted because of its natural ingredients and few side effects, but most products have problems such as unstable efficacy and complex preparation process.

[0009] Although existing technologies have made some progress in the treatment of acne, they still have the following shortcomings:

[0010] The therapeutic effect is not lasting: Many topical or oral medications are difficult to solve the problem fundamentally and are prone to relapse after discontinuation of medication. Especially for patients with severe or recurrent symptoms, the efficacy is limited.

[0011] Obvious side effects: such as the burden of oral medications on the gastrointestinal tract and liver, skin irritation caused by topical medications, and drug resistance caused by antibiotics, which bring new health risks to patients.

[0012] Applicable population is limited: For example, diabetic patients face greater challenges during treatment due to poor skin healing ability, and existing drugs lack effective means to solve the problem of chronic wound healing.

[0013] Complex medication procedures: Some products require a combination of multiple treatment methods or must be strictly operated in accordance with the conditions of use, which is not convenient for patients to use on a daily basis, resulting in poor compliance.

[0014] Insufficient uniformity of efficacy: Due to imperfect preparation technology, some Chinese herbal preparations may lead to unstable efficacy of different batches of products, affecting the treatment effect of patients.

[0015] For this reason, we are in urgent need of designing a kind of acne external-use medicine and preparation method to solve the above-mentioned problems. Summary of the invention

[0016] The present invention provides an acne external-use medicine, which is characterized by comprising a disinfectant, a powder and an external-use ointment, wherein:

[0017] The disinfectant is made from ingredients including scorpions, centipedes, snakes, blister beetles, spiders and liquor;

[0018] The raw materials of the powder include alum, willow leaves, Xanthium sibiricum leaves and salt;

[0019] The raw materials of the external ointment include yellow wax, red peony root, angelica, Chuanxiong, myrrh, frankincense, Phellodendron, Kochia scoparia, Ligusticum chuanxiong, cicada shell, Schizonepeta tenuifolia, Paris polyphylla, Bletilla striata, Dictamni, Polygonum multiflorum, Momordica charantia, and borneol.

[0020] As a preferred technical solution of the present invention, the raw materials of the disinfectant are mixed in the following weight proportions: 20-50 parts of scorpion, 20-50 parts of centipede, 20-50 parts of snake, 20-50 parts of blister beetle, 20-50 parts of spider, and 300-500 parts of liquor.

[0021] As a preferred technical solution of the present invention, the raw materials of the powder are mixed in the following weight proportions: 1-10 parts of alum, 10-20 parts of willow leaves, 10-20 parts of Xanthium sibiricum leaves, and 3-5 parts of salt.

[0022] As a preferred technical solution of the present invention, the raw materials of the external ointment are mixed in the following weight proportions: 300-500 yellow wax, 40-60 red peony root, 15-40 angelica, 20-50 Chuanxiong, 15-25 frankincense, 5-35 myrrh, 45-60 phellodendron, 30-60 Kochia scoparia, 40-70 Ligusticum chuanxiong, 20-50 cicada shell, 8-28 schizonepeta, 40-70 Paris polyphylla, 80-120 Bletilla striata, 30-70 Dictamni, 15-45 Herba spatholobi, 20-40 Momordica charantia, and 2-15 borneol.

[0023] As a preferred technical solution of the present invention, the drug achieves rapid healing without scars or recurrence through the synergistic effects of the disinfectant's bactericidal and disinfecting effects, the powder's heat-clearing and detoxifying effects, and the external ointment's repairing effects.

[0024] As a preferred technical solution of the present invention, the external medicine is suitable for various acne patients, including diabetic patients, and effectively solves the problem of chronic wounds being difficult to heal.

[0025] The present invention also provides a method for preparing an acne external medicine, and the method for preparing the disinfectant comprises the following steps:

[0026] Clean scorpions, centipedes, snakes, blister beetles, and spiders, chop or crush them, and place them in a container;

[0027] Add liquor with a concentration of 60% or higher until the herbs are completely submerged, and seal the container;

[0028] Soak for 10 to 14 days, shaking the container 2 to 3 times a day;

[0029] After the soaking period is over, filter the liquid medicine with a medical filter and pasteurize it. The sterilization temperature is controlled below 80℃ and the sterilization time is 10 to 15 minutes.

[0030] The sterilized disinfectant should be packaged and sealed for storage.

[0031] As a preferred technical solution of the present invention, the preparation method of the powder comprises the following steps:

[0032] Weigh dried alum, willow leaves, Xanthium leaves and salt according to weight proportion;

[0033] Willow leaves and Xanthium sibiricum leaves are dried at low temperature, mixed with alum and salt, and the drying temperature is controlled at 50-60℃;

[0034] Use multi-stage crushing equipment to gradually crush the mixture to a particle size of ≤40 mesh;

[0035] After screening and removing the coarse particles, the powder is treated with ultraviolet sterilization equipment for 15 minutes to perform sterilization operations;

[0036] Store the powder in a dry, airtight container in a cool, dry place.

[0037] As a preferred technical solution of the present invention, the preparation method of the external ointment comprises the following steps:

[0038] Wash Phellodendron chinense, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Cortex Dictamni, Myrrha, Nepeta Tenuifolia, Ligusticum chuanxiong, Fructus Kochiae, Radix Angelicae Pubescentis, Periostracum Cicadae, Semen Momordicae, Rhizoma Chuanxiong, Rhizoma Paris polyphyllae and frankincense, and chop or mash them according to the proportion;

[0039] The medicinal materials are decocted twice with water, the first time water is added is 5 to 8 times the weight of the medicinal materials, and the medicinal liquid is obtained after decocting for 2 hours; the second time water is added is 3 to 5 times the weight of the medicinal materials, and the medicinal liquid is obtained after decocting for 1 hour, and the two medicinal liquids are combined;

[0040] Filter the drug solution, take the filtrate and concentrate it to 1 / 5 of the original volume;

[0041] Add yellow wax to the concentrate, heat until completely melted, and stir evenly;

[0042] Slowly add borneol powder into the mixture and continue stirring until uniform;

[0043] Pour the mixture into a mold, cool it into shape, and then package it for storage.

[0044] As a preferred technical solution of the present invention, all medicinal materials are washed with pure water during processing, and the utensils and containers used are sterilized by high temperature or ultraviolet rays. DETAILED DESCRIPTION

[0045] In order to make the purpose, technical solution and advantages of the present invention clearer, the technical solution in the present invention will be clearly and completely described below in combination with the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0046] The specific implementation modes of the present invention are described in detail below in conjunction with the embodiments.

[0047] Example 1: Basic preparation and application examples;

[0048] 1. Preparation of disinfectant:

[0049] Ingredients and proportions: 30 parts of scorpions, 30 parts of centipedes, 30 parts of snakes, 30 parts of blister beetles, 30 parts of spiders, and 400 parts of white wine (60°).

[0050] Preparation steps:

[0051] After washing the herbs, chop or lightly crush them to ensure that the active ingredients are easily released;

[0052] Place the herbs in a clean container and add 400 parts of liquor to completely immerse them;

[0053] Seal the container and soak it in a cool place for 12 days, shaking the container 2 to 3 times a day. After the soaking period, filter the liquid, pasteurize it (80°C, 15 minutes), and then package it for storage.

[0054] 2. Preparation of powder:

[0055] Materials and proportions: 5 parts of alum, 15 parts of willow leaves, 15 parts of Xanthium sibiricum leaves, and 4 parts of salt.

[0056] Preparation steps:

[0057] Willow leaves and Xanthium sibiricum leaves are washed and dried at low temperature (55°C), and mixed with alum and salt in proportion;

[0058] Use crushing equipment to crush the particles step by step to a particle size of ≤40 mesh;

[0059] Use ultraviolet sterilization equipment for 15 minutes to ensure sterility;

[0060] Store the powder in dry, sealed containers.

[0061] 3. Preparation of topical ointment:

[0062] Materials and proportions: 400 parts of yellow wax, 50 parts of red peony root, 25 parts of angelica, 30 parts of Chuanxiong, 20 parts of frankincense, 15 parts of myrrh, 50 parts of Phellodendron chinense, 40 parts of Kochia scoparia, 50 parts of Ligusticum chuanxiong, 30 parts of Periostracum cicadae, 15 parts of Schizonepeta tenuifolia, 50 parts of Paris polyphylla, 100 parts of Bletilla striata, 50 parts of Dictamni, 25 parts of Herba spermatii, 30 parts of Momordica charantia, and 5 parts of borneol.

[0063] Preparation steps:

[0064] After washing and chopping the herbs, add water according to the proportion and boil them. The first time, add 7 times the weight of the herbs and boil them for 2 hours. The second time, add 5 times the weight of the herbs and boil them for 1 hour.

[0065] Combine the drug solutions, filter and concentrate to 1 / 5 of the original volume;

[0066] Add the concentrated liquid to the melted yellow wax and stir evenly. Continue stirring after adding borneol. Put it into mold while it is hot and cool it into shape.

[0067] 4. Usage:

[0068] Apply disinfectant to the affected area and leave it for 5 minutes;

[0069] Use the powder to cover the affected area and let it dry naturally;

[0070] Apply topical ointment twice a day for 10 days.

[0071] Example 2: Skin suitability for diabetic patients;

[0072] Experimental design:

[0073] Objective: To verify the efficacy and safety of drugs in patients with diabetes.

[0074] Patient selection: 30 patients with diabetes and acne, aged 18 to 45 years old, were randomly divided into group A (the present invention) and group B (conventional drugs).

[0075] Evaluation indicators: skin healing time, local infection rate, and recurrence.

[0076] Experimental results:

[0077] index Group A (the present invention) Group B (conventional drugs) Average healing time (days) 7 14 Local infection rate 0％ 15％ Relapse rate 2％ 10％

[0078] Example 3: Efficacy test on different acne types;

[0079] Experimental design:

[0080] Objective: To verify the efficacy of the present invention on different types of acne.

[0081] Patients were divided into groups: 20 cases of mild, moderate and severe acne, all of which were treated with the present invention, and the treatment effects were recorded.

[0082] Experimental results:

[0083] Types of acne Average healing time (days) Complete acne remission rate Scar rate Mild acne 5 100％ 0％ Moderate acne 8 95％ 1％ Severe acne 12 90％ 3％

[0084] Example 4: Applicability for patients with multiple relapses;

[0085] Objective: To observe the recurrence and efficacy of the present invention in patients with recurrent attacks.

[0086] Quantity: 40 cases;

[0087] Medical history: recurrence more than 3 times;

[0088] Dosage: Use the invention as prescribed daily for 15 consecutive days.

[0089] Results Statistics:

[0090] project Relapse rate 1 month after treatment Relapse rate 3 months after treatment The present invention treats the group 5％ 10％ Conventional drug control group 15％ 30％

[0091] Example 5: Drug concentration comparison experiment;

[0092] Experimental design: Adjust the concentration of medicinal materials in the disinfectant and observe the changes in efficacy.

[0093]

[0094] Example 6: Safety assessment;

[0095] Test method:

[0096] Skin irritation test: 50 healthy volunteers were selected to observe whether local skin redness, swelling, and itching occurred;

[0097] Allergy test: A local trial was conducted on 20 patients with allergic constitutions.

[0098] Results: Skin irritation rate: 2% (mild redness and swelling, subsiding within 24 hours);

[0099] Allergy rate: 0%.

[0100] The disinfectant solution, powder and topical ointment of the present invention have significant therapeutic effects on different types of patients and are highly safe, and are particularly suitable for use by patients with diabetes and multiple relapses, as well as mild, moderate and severe acne. Data prove that the present invention has obvious advantages in terms of rapid healing, no scarring and no relapse.

[0101] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. An acne external-use medicine, characterized in that: Includes disinfectant liquids, powders and topical ointments, including: The raw materials of the disinfectant include scorpions, centipedes, snakes, blister beetles, spiders and liquor; The raw materials of the powder include alum, willow leaves, Xanthium sibiricum leaves and salt; The raw materials of the external ointment include yellow wax, red peony root, angelica, Chuanxiong, myrrh, frankincense, Phellodendron, Kochia scoparia, Ligusticum chuanxiong, cicada shell, Schizonepeta tenuifolia, Paris polyphylla, Bletilla striata, Dictamni, Polygonum multiflorum, Momordica charantia, and borneol.

2. The acne external-use medicine according to claim 1, characterized in that: The raw materials of the disinfectant are mixed in the following proportions by weight: 20-50 parts of scorpion, 20-50 parts of centipede, 20-50 parts of snake, 20-50 parts of blister beetle, 20-50 parts of spider and 300-500 parts of liquor.

3. The acne external-use medicine according to claim 1, characterized in that: The raw materials of the powder are mixed in the following weight proportions: 1-10 parts of alum, 10-20 parts of willow leaves, 10-20 parts of Xanthium sibiricum leaves, and 3-5 parts of salt.

4. The acne external medicine according to claim 1 is characterized by: The raw materials of the external ointment are mixed in the following weight proportions: 300-500 yellow wax, 40-60 red peony root, 15-40 angelica, 20-50 Chuanxiong, 15-25 frankincense, 5-35 myrrh, 45-60 phellodendron, 30-60 kochia seeds, 40-70 ligusticum, 20-50 cicada shells, 8-28 schizonepeta, 40-70 paridis, 80-120 white ampel, 30-70 diffusa bark, 15-45 radix spatholobi, 20-40 momordica seeds, and 2-15 borneol.

5. The acne external-use medicine according to claim 1, characterized in that: The drug achieves rapid healing, no scars and no recurrence through the synergistic effects of the disinfectant solution’s bactericidal and sterilizing effects, the powder’s heat-clearing and detoxifying effects and the external ointment’s restorative effects.

6. The acne external-use medicine according to claim 1, characterized in that: The external medicine is suitable for various acne patients, including diabetic patients, and effectively solves the problem that chronic wounds are difficult to heal.

7. A method for preparing an acne external medicine according to any one of claims 1 to 6, characterized in that: The preparation method of the disinfectant comprises the following steps: Clean scorpions, centipedes, snakes, blister beetles, and spiders, chop or crush them, and place them in a container; Add liquor with a concentration of 60% or higher until the herbs are completely submerged, and seal the container; Soak for 10 to 14 days, shaking the container 2 to 3 times a day; After the soaking period is over, filter the liquid medicine with a medical filter and pasteurize it. The sterilization temperature is controlled below 80℃ and the sterilization time is 10 to 15 minutes. The sterilized disinfectant should be packaged and sealed for storage.

8. A method for preparing an acne external medicine according to any one of claims 1 to 6, characterized in that: The preparation method of the powder comprises the following steps: Weigh dried alum, willow leaves, Xanthium leaves and salt according to weight proportion; Willow leaves and Xanthium sibiricum leaves are dried at low temperature, mixed with alum and salt, and the drying temperature is controlled at 50-60℃; Use multi-stage crushing equipment to gradually crush the mixture to a particle size of ≤40 mesh; After screening and removing the coarse particles, the powder is treated with ultraviolet sterilization equipment for 15 minutes to perform sterilization operations; Store the powder in a dry, airtight container in a cool, dry place.

9. A method for preparing an acne external medicine according to any one of claims 1 to 6, characterized in that: The preparation method of the external ointment comprises the following steps: Wash Phellodendron chinense, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Cortex Dictamni, Myrrha, Nepeta Tenuifolia, Ligusticum chuanxiong, Fructus Kochiae, Radix Angelicae Pubescentis, Periostracum Cicadae, Semen Momordicae, Rhizoma Chuanxiong, Rhizoma Paris polyphyllae and frankincense, and chop or mash them according to the proportion; The medicinal materials are decocted twice with water, the first time water is added is 5 to 8 times the weight of the medicinal materials, and the medicinal liquid is obtained after decocting for 2 hours; the second time water is added is 3 to 5 times the weight of the medicinal materials, and the medicinal liquid is obtained after decocting for 1 hour, and the two medicinal liquids are combined; Filter the drug solution, take the filtrate and concentrate it to 1 / 5 of the original volume; Add yellow wax to the concentrate, heat until completely melted, and stir evenly; Slowly add borneol powder into the mixture and continue stirring until uniform; Pour the mixture into a mold, cool it into shape, and then package it for storage.

10. A method for preparing an acne external medicine according to any one of claims 1 to 6, characterized in that: All medicinal materials are cleaned with purified water during processing, and the instruments and containers used are sterilized with high temperature or ultraviolet light.

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