Medicine for nursing biliary tract and preparation process thereof

Abstract

The medicine for nursing the biliary tract is prepared from the following raw materials in parts by mass: 5 to 10 parts of fructus mume, 3 to 7 parts of origanum vulgare, 4 to 8 parts of fructus citri sarcodactylis, 6 to 10 parts of radix curcumae and 4 to 9 parts of rhizoma cyperi. According to the traditional Chinese medicine composition, the smoked plums, the origanum vulgare, the fingered citron, the radix curcumae and the rhizoma cyperi are combined according to a specific mass part ratio, all the traditional Chinese medicine raw material components have a synergistic effect, the effects of effectively promoting biliary secretion and inhibiting gallstone formation are embodied, and the remarkable biliary tract nursing effect is achieved. The raw material components adopted by the medicine for nursing the biliary tract provided by the invention are non-toxic to a human body and do not generate obvious side effects, and the medicine is simple in preparation process, low in production cost and high in production efficiency.

Description

Technical Field

[0001] The invention belongs to the field of medicines, and in particular relates to a medicine for nursing the bile duct and a preparation process thereof. Background Art

[0002] The biliary system is a pipe structure that transports bile secreted by the liver to the duodenum, including the intrahepatic and extrahepatic bile ducts, the gallbladder and the sphincter of Oddi. The biliary system has the functions of secreting, storing, concentrating and transporting bile, and plays an important role in regulating the discharge of bile into the duodenum. About 3 / 4 of the bile is mainly secreted by liver cells, and the bile secreted by the bile duct accounts for only 1 / 4 of the total. Bile is an important digestive fluid, and its main components include bile acid, bile salts, cholesterol, lecithin, bile pigments, etc. Bile can combine with fat in food to form water-soluble fat particles, and stimulate the secretion of pancreatic juice and activate the digestive enzymes therein to facilitate the absorption of fat, cholesterol and fat-soluble vitamins; bile can stimulate intestinal peristalsis and neutralize gastric acid, and the bile salts in bile can also inhibit the growth and reproduction of pathogenic bacteria in the intestine. The secretion and discharge of bile are regulated by the nervous system and endocrine hormones. Most of the bile secreted by liver cells and bile ducts is stored in the gallbladder. When food reaches the duodenum, the gallbladder will contract and control the relaxation of the sphincter of Oddi to facilitate the discharge of bile. If the discharge of bile is blocked, it will affect the liver and cause changes in liver function. In severe cases, it may even lead to biliary cirrhosis. If combined with bile duct infection, it will cause acute obstructive suppurative cholangitis. These conditions require surgical operation to be cured.

[0003] The gallbladder is a cystic organ that is only connected to the common bile duct by the cystic duct. When the ingested food requires bile to help digestion, the gallbladder contracts and discharges bile, and when the stomach is empty, the excess bile will be stored and concentrated in the gallbladder. The concentration of bile components in the gallbladder is often very high. If the concentration is too high or the bile in the gallbladder cannot be emptied or replaced in time, gallstones may form, and the formed stones will in turn affect the function of the gallbladder. Therefore, the gallbladder function, gallstones, and changes in the bile components in the gallbladder are mutually causal, so the care of the bile duct is particularly important for human health. In recent years, many traditional Chinese medicines have been found to be an effective medicine for the care of the bile duct, but due to various reasons such as the large number of ingredients and unsatisfactory ratios, it is difficult to achieve a more obvious therapeutic effect. Summary of the invention

[0004] In view of the deficiencies in the above-mentioned prior art, the present invention provides a medicine for nursing the bile duct and a preparation process thereof, through a combination of black plum, oregano, bergamot, curcuma, and cyperus in a specific mass ratio, each Chinese medicine raw material component synergistically promotes bile secretion and inhibits the formation of gallstones, and has a significant effect of nursing the bile duct. The raw material components used in the medicine for nursing the bile duct provided by the present invention are all natural products, non-toxic and harmless to the human body, no side effects, low preparation cost, and simple preparation process.

[0005] The object of the present invention is to provide a medicine for nursing the bile duct, which comprises the following raw materials in parts by weight: 5 to 10 parts of black plum, 3 to 7 parts of oregano, 4 to 8 parts of bergamot, 6 to 10 parts of curcuma, and 4 to 9 parts of cyperus.

[0006] The inventors found during the experiment that the medicine prepared by combining a specific proportion of black plum, oregano, bergamot, curcuma, and cyperus rotundus can effectively promote bile secretion, inhibit the formation of gallstones, and has a significant effect on the care of the bile duct through the synergistic effect of the components.

[0007] In some embodiments of the present invention, the medicine comprises the following raw materials in parts by weight: 6-8 parts of ebony, 5-7 parts of oregano, 5-7 parts of bergamot, 7-9 parts of curcuma, and 5-7 parts of cyperus.

[0008] In some embodiments of the present invention, the medicine comprises the following raw materials in parts by weight: 6 parts of black plum, 5 parts of oregano, 7 parts of bergamot, 9 parts of curcuma, and 5 parts of cyperus.

[0009] In some embodiments of the present invention, the medicine also includes the following raw materials in parts by weight: 3-8 parts of Citrus aurantium, 5-11 parts of Rhubarb, 6-10 parts of Clematis, 2-7 parts of Licorice, 3-8 parts of Lysimachia scabra, 4-10 parts of Chicken Gizzard Stone, and 5-12 parts of Curcuma longa.

[0010] In some embodiments of the present invention, the drug further comprises the following raw materials in parts by weight: 8 to 15 parts of starch and 9 to 16 parts of talc.

[0011] In some embodiments of the present invention, the drug is an oral preparation.

[0012] In some embodiments of the present invention, the drug is in the form of pills, capsules, tablets, granules or powders.

[0013] Another object of the present invention is to provide a process for preparing the above-mentioned drug, comprising the following steps:

[0014] S1. Mix black plum, oregano, bergamot, curcuma, cyperus, immature bitter orange, rhubarb, clematis, licorice, Lysimachia chinensis, chicken gizzard lining, and turmeric, add water and boil to obtain a decoction;

[0015] S2. Filter the decoction to obtain a filtrate, and concentrate the filtrate to obtain a clear paste;

[0016] S3. Add ethanol to the clear paste, stir well, let stand, take the supernatant, and concentrate the supernatant to obtain a thick paste;

[0017] S4. The thick paste is crushed, starch and talcum powder are added, mixed, dried, and made into a drug in the form of pills, capsules, tablets, granules or powders.

[0018] In some embodiments of the present invention, in S1, the decocting temperature is 60-80° C. and the decocting time is 5-8 hours.

[0019] In some embodiments of the present invention, in S1, the decocting times are 3 times, each time for 2 hours.

[0020] In some embodiments of the present invention, in S1, the amount of water used is 6 to 8 times the total mass of black plum, oregano, bergamot, curcuma, cyperus rotundus, immature bitter orange, rhubarb, clematis, licorice, Lysimachia chinensis, chicken gizzard lining, and turmeric.

[0021] In some embodiments of the present invention, in S2, the relative density of the concentrated filtrate at 80°C is 1.10-1.20.

[0022] In some embodiments of the present invention, in S3, the mass ratio of the ethanol to the clear paste is 7:3.

[0023] In some embodiments of the present invention, in S3, the standing time is 24 hours.

[0024] In some embodiments of the present invention, in S3, the relative density of the concentrated supernatant at 80°C is 1.20-1.25.

[0025] In some embodiments of the present invention, in S4, the dosage form of the drug is a capsule.

[0026] Another object of the present invention is to provide the use of the medicine in nursing the bile duct.

[0027] In some embodiments of the present invention, the symptom of the bile duct is at least one of bile duct infection, excessive bile secretion or gallstones.

[0028] Compared with the prior art, the present invention has the following beneficial effects:

[0029] (1) The raw materials used in the medicine of the present invention are all Chinese medicinal ingredients that are non-toxic to the human body, have mild medicinal properties, and do not produce obvious side effects.

[0030] (2) Animal experiments have shown that the combination of black plum, oregano, bergamot, curcuma and cyperus rotundus in the medicine of the present invention can significantly promote bile secretion, effectively inhibit the formation of gallstones, and has a significant gallbladder protection effect.

[0031] (3) The preparation process of the drug of the present invention is simple, with low production cost and high production efficiency. DETAILED DESCRIPTION

[0032] In order to enable those skilled in the art to better understand the technical solutions of the present invention, the technical solutions of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of the present invention.

[0033] Example 1

[0034] This embodiment provides a drug for nursing the bile duct, and the specific preparation steps are as follows:

[0035] S1. The 5 parts by mass of ebony, 3 parts by mass of oregano, 8 parts by mass of bergamot, 10 parts by mass of turmeric, 4 parts by mass of cyperus, 6 parts by mass of immature bitter orange, 11 parts by mass of rhubarb, 6 parts by mass of clematis, 7 parts by mass of licorice, 3 parts by mass of Lysimachia, 10 parts by mass of chicken gizzard, 12 parts by mass of turmeric were mixed, 510 parts by mass of water were added and boiled at 60-80 ° C for 5-8 hours, boiled 3 times for 2 hours each time to obtain a decoction;

[0036] S2. Filter the decoction to obtain a filtrate, and concentrate the filtrate until the relative density of the filtrate at 80° C. is 1.10 to 1.20 to obtain a clear paste;

[0037] S3. Add ethanol to the clear paste to make the alcohol content of the clear paste to 70wt%, stir for 0.5 hours, let stand for 24 hours, take the supernatant, and concentrate it to a relative density of 1.20 to 1.25 at 80 ℃ to obtain a thick paste;

[0038] S4. The thick paste is crushed, 8 parts by mass of starch and 16 parts by mass of talc are added, mixed, dried, and prepared into a drug in the form of a capsule.

[0039] Example 2

[0040] This embodiment provides a drug for nursing the bile duct, and the specific preparation steps are as follows:

[0041] S1. Mix 10 parts by mass of ebony, 7 parts by mass of oregano, 4 parts by mass of bergamot, 6 parts by mass of turmeric, 9 parts by mass of cyperus, 3 parts by mass of immature bitter orange, 15 parts by mass of rhubarb, 10 parts by mass of clematis, 2 parts by mass of licorice, 5 parts by mass of desmodium, 4 parts by mass of chicken gizzard, and 10 parts by mass of turmeric, add 736 parts by mass of water and cook at 60-80 ° C for 5-8 hours, cook 3 times for 2 hours each time to obtain a decoction;

[0042] S2. Filter the decoction to obtain a filtrate, and concentrate the filtrate until the relative density of the filtrate at 80° C. is 1.10 to 1.20 to obtain a clear paste;

[0043] S3. Add ethanol to the clear paste to make the alcohol content of the clear paste to 70wt%, stir for 0.5 hours, let stand for 24 hours, take the supernatant, and concentrate it to a relative density of 1.20 to 1.25 at 80 ℃ to obtain a thick paste;

[0044] S4. The thick paste is crushed, 15 parts by mass of starch and 9 parts by mass of talc are added, mixed, dried, and prepared into a drug in the form of a capsule.

[0045] Example 3

[0046] This embodiment provides a drug for nursing the bile duct, and the specific preparation steps are as follows:

[0047] S1. Mix 6 parts by mass of ebony, 5 parts by mass of oregano, 7 parts by mass of bergamot, 9 parts by mass of turmeric, 5 parts by mass of cyperus, 8 parts by mass of immature bitter orange, 10 parts by mass of rhubarb, 8 parts by mass of clematis, 6 parts by mass of licorice, 8 parts by mass of Lysimachia chinensis, 8 parts by mass of chicken gizzard, and 5 parts by mass of turmeric, add 600 parts by mass of water, boil at 60 to 80 ° C for 5 to 8 hours, boil 3 times for 2 hours each time to obtain a decoction;

[0048] S2. Filter the decoction to obtain a filtrate, and concentrate the filtrate until the relative density of the filtrate at 80° C. is 1.10 to 1.20 to obtain a clear paste;

[0049] S3. Add ethanol to the clear paste to make the alcohol content of the clear paste to 70wt%, stir for 0.5 hours, let stand for 24 hours, take the supernatant, and concentrate it to a relative density of 1.20 to 1.25 at 80 ℃ to obtain a thick paste;

[0050] S4. The thick paste is crushed, 12 parts by mass of starch and 12 parts by mass of talc are added, mixed, dried, and prepared into a drug in the form of a capsule.

[0051] Comparative Example 1

[0052] This comparative example provides a drug for nursing the bile duct, and the specific preparation steps are as follows:

[0053] S1. The ebony 32 mass parts, 8 mass parts of Citrus aurantium, 10 mass parts of rhubarb, 8 mass parts of Clematis, 6 mass parts of licorice, 8 mass parts of Lysimachia chinensis, 8 mass parts of chicken gizzard, 5 mass parts of turmeric were mixed, 600 mass parts of water were added, decocted at 60 to 80 ° C for 5 to 8 hours, decocted 3 times, each time for 2 hours, to obtain a decoction;

[0054] S2. Filter the decoction to obtain a filtrate, and concentrate the filtrate until the relative density of the filtrate at 80° C. is 1.10 to 1.20 to obtain a clear paste;

[0055] S3. Add ethanol to the clear paste to make the alcohol content of the clear paste to 70wt%, stir for 0.5 hours, let stand for 24 hours, take the supernatant, and concentrate it to a relative density of 1.20 to 1.25 at 80 ℃ to obtain a thick paste;

[0056] S4. The thick paste is crushed, 12 parts by mass of starch and 12 parts by mass of talc are added, mixed, dried, and prepared into a drug in the form of a capsule.

[0057] Comparative Example 2

[0058] This comparative example provides a drug for nursing the bile duct, and the specific preparation steps are as follows:

[0059] S1. The oregano 32 mass parts, Citrus aurantium 8 mass parts, rhubarb 10 mass parts, Clematis 8 mass parts, licorice 6 mass parts, Lysimachia 8 mass parts, chicken gizzard 8 mass parts, turmeric 5 mass parts mixed, add 600 mass parts of water, 60 ~ 80 ℃ decocted for 5 to 8 hours, decocted 3 times, each time for 2 hours, to obtain a decoction;

[0060] S2. Filter the decoction to obtain a filtrate, and concentrate the filtrate until the relative density of the filtrate at 80° C. is 1.10 to 1.20 to obtain a clear paste;

[0061] S3. Add ethanol to the clear paste to make the alcohol content of the clear paste to 70wt%, stir for 0.5 hours, let stand for 24 hours, take the supernatant, and concentrate it to a relative density of 1.20 to 1.25 at 80 ℃ to obtain a thick paste;

[0062] S4. The thick paste is crushed, 12 parts by mass of starch and 12 parts by mass of talc are added, mixed, dried, and prepared into a drug in the form of a capsule.

[0063] Comparative Example 3

[0064] This comparative example provides a drug for nursing the bile duct, and the specific preparation steps are as follows:

[0065] S1. The bergamot 32 parts by mass, 8 parts by mass of Citrus aurantium, 10 parts by mass of rhubarb, 8 parts by mass of Clematis, 6 parts by mass of licorice, 8 parts by mass of Lysimachia chinensis, 8 parts by mass of chicken gizzard, 5 parts by mass of turmeric were mixed, 600 parts by mass of water were added, and the mixture was boiled at 60 to 80 ° C for 5 to 8 hours, and boiled 3 times for 2 hours each time to obtain a decoction;

[0066] S2. Filter the decoction to obtain a filtrate, and concentrate the filtrate until the relative density of the filtrate at 80° C. is 1.10 to 1.20 to obtain a clear paste;

[0067] S3. Add ethanol to the clear paste to make the alcohol content of the clear paste to 70wt%, stir for 0.5 hours, let stand for 24 hours, take the supernatant, and concentrate it to a relative density of 1.20 to 1.25 at 80 ℃ to obtain a thick paste;

[0068] S4. The thick paste is crushed, 12 parts by mass of starch and 12 parts by mass of talc are added, mixed, dried, and prepared into a drug in the form of a capsule.

[0069] Comparative Example 4

[0070] This comparative example provides a drug for nursing the bile duct, and the specific preparation steps are as follows:

[0071] S1. The 32 parts by mass of turmeric, 8 parts by mass of Citrus aurantium, 10 parts by mass of rhubarb, 8 parts by mass of clematis, 6 parts by mass of licorice, 8 parts by mass of Lysimachia chinensis, 8 parts by mass of chicken gizzard, 5 parts by mass of turmeric were mixed, 600 parts by mass of water were added, and the mixture was boiled at 60 to 80 ° C for 5 to 8 hours, and boiled 3 times for 2 hours each time to obtain a decoction;

[0072] S2. Filter the decoction to obtain a filtrate, and concentrate the filtrate until the relative density of the filtrate at 80° C. is 1.10 to 1.20 to obtain a clear paste;

[0073] S3. Add ethanol to the clear paste to make the alcohol content of the clear paste to 70wt%, stir for 0.5 hours, let stand for 24 hours, take the supernatant, and concentrate it to a relative density of 1.20 to 1.25 at 80 ℃ to obtain a thick paste;

[0074] S4. The thick paste is crushed, 12 parts by mass of starch and 12 parts by mass of talc are added, mixed, dried, and prepared into a drug in the form of a capsule.

[0075] Comparative Example 5

[0076] This comparative example provides a drug for nursing the bile duct, and the specific preparation steps are as follows:

[0077] S1. The 32 parts by mass of Cyperus rotundus, 8 parts by mass of Citrus aurantium, 10 parts by mass of rhubarb, 8 parts by mass of Clematis, 6 parts by mass of licorice, 8 parts by mass of Lysimachia chinensis, 8 parts by mass of chicken gizzard, 5 parts by mass of turmeric were mixed, 600 parts by mass of water were added, and the mixture was boiled at 60 to 80 ° C for 5 to 8 hours, and boiled 3 times for 2 hours each time to obtain a decoction;

[0078] S2. Filter the decoction to obtain a filtrate, and concentrate the filtrate until the relative density of the filtrate at 80° C. is 1.10 to 1.20 to obtain a clear paste;

[0079] S3. Add ethanol to the clear paste to make the alcohol content of the clear paste to 70wt%, stir for 0.5 hours, let stand for 24 hours, take the supernatant, and concentrate it to a relative density of 1.20 to 1.25 at 80 ℃ to obtain a thick paste;

[0080] S4. The thick paste is crushed, 12 parts by mass of starch and 12 parts by mass of talc are added, mixed, dried, and prepared into a drug in the form of a capsule.

[0081] Performance Testing:

[0082] 1. Effects on bile flow, total cholesterol and total bilirubin content in rats:

[0083] The present invention selects rats weighing 300-350g as experimental animals, and the rats are first adapted to the environment for one week before the experiment. The rats are randomly divided into 9 groups, each with 10 rats, and each group is given the drugs described in Examples 1-3 and Comparative Examples 1-5, respectively, numbered as groups a-h, and the dosage of groups a-h is 150mg drug / 100g body weight / time, respectively, and the blank control group is given distilled water of equal mass; the rats are fasted for 12h before the experiment, but not water, and each rat is intraperitoneally injected with 40mg / kg of sodium pentobarbital for anesthesia during the experiment, fixed on the operating table in the supine position, cut about 2cm along the midline of the abdomen, open the abdominal cavity, perform bile duct intubation, insert a polyethylene tube into the bile duct, and after the bile enters the tube, ligature and fix it, collect bile with a 1.5mL V-tube, and after stabilization for 10min, record once every 30min, collect the amount of bile for 1h, and take the average value as the bile secretion before administration. Then, the drug was administered intraduodenally, and the bile secretion at different times after administration was collected, 3 times for a total of 1.5 hours, and each group was compared with itself before and after. The increase rate of bile secretion in each time period (%) was calculated; according to the method of the total bilirubin kit, the last bile and the bile before administration were respectively measured with a spectrophotometer at the end of the experiment. The ratio change of total bilirubin in bile before and after administration (bilirubin content after administration / bilirubin content before administration) was calculated. The specific results are shown in Tables 1 and 2.

[0084] Table 1. Effects of the present invention on bile secretion in rats.

[0085]

[0086] As shown in the results of Table 1, groups a to c can significantly increase the bile flow of rats, while groups d to h have a relatively insignificant increase in the bile flow of rats, indicating that the five components of the drug of the present invention, namely, black plum, oregano, bergamot, curcuma, and cyperus, work together to enhance the effect and effectively promote the secretion of bile, while the drug made of a single component has a relatively insignificant effect in promoting bile secretion.

[0087] Table 2. Effect of the present invention on the total bilirubin content in rat bile.

[0088]

[0089]

[0090] As shown in Table 2, compared with the blank control group, groups a to c of the present invention have significant choleretic effects, and are more effective in promoting the excretion of bilirubin in rat bile, and have significant bile duct care effects; while groups d to h are relatively less effective in the excretion of bilirubin in rat bile;

[0091] 2. Effect on inhibiting gallstone formation

[0092] Mice weighing 20 to 22 g were used as experimental animals. Before the experiment, the mice were allowed to adapt to the environment for one week. The mice were randomly divided into 9 groups, 10 in each group. The drugs described in Examples 1 to 3 and Comparative Examples 1 to 5 were numbered as groups a to h, respectively. The blank control group was fed with normal feed + lithogenic feed, and the mice in the other groups were fed with lithogenic feed and normal feed. Each mouse was fed 6 g of feed per day. The main ingredients of the lithogenic feed are: 1% cholesterol and 0.5% bile acid are added to the normal feed. The test drugs a to h were evenly mixed into the lithogenic feed, and made into soft food to feed the mice. After 30 days of the experiment, blood was taken and the gallbladder was removed under anesthesia to determine the serum total cholesterol content and observe whether there was gallstone formation in the gallbladder.

[0093] Table 3. Effect of the present invention on inhibiting gallstone formation in mice.

[0094]

[0095]

[0096] As can be seen from Table 3, groups a to c significantly reduced the formation of gallstones in mice caused by the lithogenic feed, while groups d to h had no obvious inhibitory effect on gallstone formation. This shows that the combination of black plum, oregano, bergamot, curcuma, and cyperus rotundus in the medicine of the present invention can significantly inhibit the formation of gallstones.

[0097] The above embodiments are only used to illustrate the technical solutions of the present invention rather than to limit the same. Although the present invention has been described in detail with reference to the above embodiments, ordinary technicians in the relevant field should understand that after reading the specification of this application, the technicians can still modify or replace the specific implementation methods of the present invention with equivalents, but these modifications or changes do not deviate from the scope of protection of the pending claims of the present application.

Claims

1. A drug for nursing the bile duct, characterized in that: The medicine comprises the following raw materials in parts by weight: 5-10 parts of black plum, 3-7 parts of oregano, 4-8 parts of bergamot, 6-10 parts of curcuma, and 4-9 parts of cyperus.

2. The drug according to claim 1, characterized in that The medicine also includes the following raw materials in parts by weight: 3-8 parts of immature bitter orange, 5-11 parts of rhubarb, 6-10 parts of clematis, 2-7 parts of liquorice, 3-8 parts of desmodium, 4-10 parts of chicken gizzard lining, and 5-12 parts of turmeric.

3. The drug according to claim 2, characterized in that The medicine further comprises the following raw materials in parts by weight: 8 to 15 parts of starch and 9 to 16 parts of talc.

4. The drug according to any one of claims 1 to 3, characterized in that The medicine is an oral preparation.

5. The drug according to claim 4, characterized in that The dosage form of the medicine is pill, capsule, tablet, granule or powder.

6. The process for preparing the drug according to claim 3, characterized in that: The preparation process comprises the following steps: S1. Mix black plum, oregano, bergamot, curcuma, cyperus, immature bitter orange, rhubarb, clematis, licorice, Lysimachia chinensis, chicken gizzard lining, and turmeric, add water and boil to obtain a decoction; S2. Filter the decoction to obtain a filtrate, and concentrate the filtrate to obtain a clear paste; S3. Add ethanol to the clear paste, stir well, let stand, take the supernatant, and concentrate the supernatant to obtain a thick paste; S4. The thick paste is crushed, starch and talcum powder are added, mixed, dried, and made into a drug in the form of pills, capsules, tablets, granules or powders.

7. Use of the drug as described in any one of claims 1 to 3 in nursing the bile duct.

8. The use according to claim 7, characterized in that The symptom of the bile duct is at least one of bile duct infection, excessive bile secretion or gallstones.

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