A nucleic acid detection and analysis device with a mixing structure

Abstract

The present invention discloses a nucleic acid detection and analysis device with a mixing structure, which relates to the technical field of nucleic acid detection and analysis devices. The device includes a detection box. A placement table is fixedly installed at the inner bottom of the detection box. Driving rods are rotatably connected to the peripheries of the placement table. A pair of second gears are fixed on each driving rod. A chain belt is sleeved on the multiple second gears. A plurality of magnetic attraction seats are fixedly installed on the inner ring of the chain belt. A pair of slicing pieces are fixedly connected to one side of each magnetic attraction seat. A docking table is fixedly installed at the top of the placement table. Insertion rods are detachably connected to both sides of the top of the docking table. A top positioning piece is fixedly connected to the top of each insertion rod. In this nucleic acid detection and analysis device with a mixing structure, the reagent kit and the top positioning piece are detachable, so that during the process of detecting results, the sampling needle and the magnetic head seat can be disinfected simultaneously. The two operations are synchronous, which improves the number of samples detected by the device in a short time and also reduces the detection time of the samples.

Description

Technical Field

[0001] The present invention relates to the technical field of nucleic acid detection and analysis devices, and particularly to a nucleic acid detection and analysis device with a mixing structure. Background Art

[0002] After the existing nucleic acid is sampled, the whole device is mixed and then placed in a detection instrument for detection. First, during sampling, the existing device generally holds multiple DNA fragments to be analyzed on a planar substrate and identifies the base sequences of the multiple held DNA fragments in parallel. The invention patent with the authorization number of CN115521863B in China proposes a technical solution. This solution separates by using a pipette cylinder and a soft rubber sleeve, then drives the pipette cylinder to descend so that the piston rod sucks the sample into the pipette cylinder. Immediately afterwards, the driving device moves above the reagent kit. Finally, during the process of lowering the piston rod, the sample inside the pipette cylinder is squeezed into the reagent kit for reaction. Finally, it is detected by an optical detector and the information is transmitted to the host computer. Although it can detect nucleic acid detection and analysis, because only a single translation unit is used to implement the translational movement in one direction, for example, in the case of processing multiple batches of sampled samples, it is necessary to disinfect the inside of the pipette cylinder multiple times before use, the required movement amount increases, and due to connection structures such as the piston rod, the disinfection time inside the pipette cylinder is relatively long, the operations performed by the device are relatively cumbersome, and the detection efficiency is relatively low. For this reason, we propose a nucleic acid detection and analysis device with a mixing structure. Summary of the Invention

[0003] The purpose of the present invention is to provide a nucleic acid detection and analysis device with a mixing structure to solve the problems raised in the above background art.

[0004] To achieve the above purpose, the present invention provides the following technical solution: A nucleic acid detection and analysis device with a mixing structure, including a detection box. A placement table is fixedly installed at the inner bottom of the detection box. Driving rods are rotatably connected to the peripheries of the placement table. A pair of second gears are fixed on each driving rod. A chain belt is sleeved on the multiple second gears. A plurality of magnetic suction seats are fixedly installed on the inner circle of the chain belt. A pair of shaving pieces are fixedly connected to one side of each magnetic suction seat. A docking table is fixedly installed at the top of the placement table. Insertion rods are detachably connected to both sides of the top of the docking table. A top position piece is fixedly connected to the top of each insertion rod. A drainage machine is fixedly connected to the middle of one side of the outer part of the detection box. A spraying and pressing chamber is fixedly arranged on one side inside the detection box. The spraying and pressing chamber is fixedly connected to the drainage machine. One of the top position pieces is located inside the spraying and pressing chamber. A reagent kit is detachably connected to one side of the docking table. A first cylinder is suspended at the top inside the detection box. A detector is fixedly connected to the bottom of the first cylinder;

[0005] One side of the placement table is fixedly connected with a mixing structure for mixing the sampling tube. After the mixing structure contacts the shaving piece, the liquid to be tested is transferred to the inside of the test kit through the movement of the chain belt for testing.

[0006] Preferably, the mixing structure includes a plurality of driving rods rotatably connected to the top inside the test box. A gasket is fixedly connected to the bottom of each driving rod, and a first gear is fixedly connected to the top of each driving rod. A motor is fixedly connected to the top of the test box. A belt is sleeved on the output shaft of the motor. One end of the belt is sleeved on a rotating rod. One end of the rotating rod is suspended inside the test box through the test box. A middle block is slidably connected to the bottom of the rotating rod. A mixing disc is slidably connected to the outside of the middle block. A first spring is fixedly connected to the inner bottom of the rotating rod. The first spring is fixedly connected to the middle block. A driving gear is fixedly installed on the top of the rotating rod. The driving gear meshes with each of the first gears.

[0007] Preferably, a placement area is formed by the middle part of the mixing disc sinking downward. The placement area is in an annular shape and is provided with a plurality of puncture holes at the bottom. The placement area is slidably connected to the sampling tube.

[0008] Preferably, a base is fixedly connected to one side of the top of the placement table. A second cylinder is fixedly connected to the middle of the base. A quantitative sampling device for extracting the liquid to be tested inside the sampling tube is installed on the top of the second cylinder.

[0009] Preferably, the quantitative sampling device includes a connecting cylinder fixed to the top of the second cylinder. A magnetic chuck is installed on the top of the connecting cylinder. A plurality of magnetic head seats are magnetically connected to the top of the magnetic chuck. A sampling needle is fixedly connected to the bottom of each magnetic head seat. Each sampling needle corresponds to the bottom of the puncture hole.

[0010] Preferably, the quantitative sampling device further includes an insertion piece arranged at the top of the outer ring of the connecting cylinder. A groove corresponding to the insertion piece is opened in the inner ring of the magnetic chuck. A second spring is fixedly connected to the inside of the connecting cylinder. A lifting plate is fixedly connected to the top of the second spring. The lifting plate extends towards the bottom of the magnetic chuck and contacts the bottom of the magnetic chuck.

[0011] Preferably, a discharge cavity is opened inside each magnetic head seat. A control ball is movably connected to the inside of the discharge cavity. When the shaving piece contacts the bottom of the magnetic head seat, the magnetic head seat and the magnetic suction seat are attracted together by magnetism. When the top piece contacts the control ball, the control ball moves inside the discharge cavity.

[0012] Preferably, each discharge cavity communicates with the sampling needle, and it has a shape with the side wall of the inner top extending downward to form a shape that is wider at the top and narrower at the bottom. The bottom of the discharge cavity fits with the control ball.

[0013] Preferably, the material control ball is made of metal and its surface is polished.

[0014] Preferably, one end of the docking platform is detachably connected with a collection bin, and the top of the collection bin communicates with the bottom of the spraying and pressing chamber.

[0015] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0016] When the magnetic attraction seat of the present invention is displaced above the top position piece, the chip crosses the side wall of the top position piece, the material control ball contacts the top position piece, so that the material control ball rolls above the top position piece. At the same time, the top position piece pushes the material control ball upward to open the discharge cavity inside the magnetic head seat, so that the liquid to be detected drips from the discharge cavity along the top position piece into the reagent kit; when the material control ball contacts the top position piece again, disinfectant liquid enters the sampling needle and the discharge cavity to disinfect them thoroughly. After disinfection, the disinfected water flows into the collection bin and can be poured out manually after it is full. The reagent kit and the top position piece are detachable, so that during the detection process of the device, the sampling needle and the magnetic head seat are disinfected simultaneously, and the two operations are synchronous, which improves the number of samples detected by the device in a short time and also reduces the detection time of the samples. Description of the Drawings

[0017] Figure 1 is a schematic diagram of the overall structure of the present invention;

[0018] Figure 2 is a schematic diagram of the overall structure of the present invention in an open state;

[0019] Figure 3 is the present invention Figure 2 is an enlarged schematic diagram of part A in the present invention;

[0020] Figure 4 is a schematic diagram of the mixing structure and the quantitative sampling device structure of the present invention;

[0021] Figure 5 is the present invention Figure 4 is an enlarged schematic diagram of part B in the present invention;

[0022] Figure 6 is a schematic diagram of the reagent kit structure of the present invention;

[0023] Figure 7 is the present invention Figure 6 is an enlarged schematic diagram of part C in the present invention;

[0024] Figure 8 is a schematic diagram of the drainage machine and the spraying and pressing chamber structure of the present invention;

[0025] Figure 9 is a schematic diagram of the magnetic head seat and the material control ball structure of the present invention.

[0026] In the figure: 1 - detection box; 2 - drainage machine; 3 - motor; 4 - belt; 5 - first cylinder; 501 - detector; 6 - placement table; 7 - docking table; 8 - first gear; 9 - chain belt; 10 - base; 11 - second gear; 12 - second cylinder; 1201 - connecting cylinder; 13 - transmission rod; 14 - gasket; 15 - rotating rod; 16 - mixing plate; 17 - first spring; 18 - middle block; 19 - magnetic chuck; 20 - second spring; 21 - lifting plate; 22 - magnetic head seat; 2201 - discharge chamber; 23 - sampling needle; 24 - material control ball; 25 - collection bin; 26 - spray pressure chamber; 27 - reagent kit; 28 - insertion rod; 29 - top position piece; 30 - magnetic attraction seat; 31 - shaving piece. Detailed implementation manner

[0027] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0028] Please refer to Figures 1-9, the present invention provides a technical solution: a nucleic acid detection and analysis device with a mixing structure, including a detection box 1. A placement table 6 is fixedly installed at the inner bottom of the detection box 1. Driving rods are rotatably connected to the periphery of the placement table 6. A pair of second gears 11 are fixed on each driving rod. A chain belt 9 is sleeved on multiple second gears 11. A plurality of magnetic suction seats 30 are fixedly installed on the inner ring of the chain belt 9. A pair of shaving pieces 31 are fixedly connected to one side of each magnetic suction seat 30. A docking platform 7 is fixedly installed on the top of the placement table 6. Insertion rods 28 are detachably connected to both sides of the top of the docking platform 7. A top position piece 29 is fixedly connected to the top of each insertion rod 28. The middle part of one side of the detection box 1 is fixedly connected with a drainage machine 2. A spraying and pressing chamber 26 is fixedly arranged on one side inside the detection box 1. The spraying and pressing chamber 26 is fixedly connected with the drainage machine 2. One of the top position pieces 29 is located inside the spraying and pressing chamber 26. A reagent kit 27 is detachably connected to one side of the docking platform 7. A first cylinder 5 is suspended at the inner top of the detection box 1. The bottom of the first cylinder 5 is fixedly connected with a detector 501; A mixing structure for mixing the sampling tube is fixedly connected to one side of the placement table 6. The mixing structure transfers the liquid to be detected into the reagent kit 27 for detection after contacting with the shaving pieces 31 and then moving through the chain belt 9; The mixing structure includes a plurality of transmission rods 13 rotatably connected to the inner top of the detection box 1. A gasket 14 is fixedly connected to the bottom of each transmission rod 13. A first gear 8 is fixedly connected to the top of each transmission rod 13. A motor 3 is fixedly connected to the top of the detection box 1. A belt 4 is sleeved on the output shaft of the motor 3. One end of the belt 4 is sleeved on a rotating rod 15. One end of the rotating rod 15 is suspended inside the detection box 1 through the detection box 1. The bottom of the rotating rod 15 is slidably connected with a middle block 18. A mixing disk 16 is slidably connected to the outside of the middle block 18. A first spring 17 is fixedly connected to the inner bottom of the rotating rod 15. The first spring 17 is fixedly connected with the middle block 18. A driving gear is fixedly installed on the top of the rotating rod 15. The driving gear meshes with each first gear 8; The middle part of the mixing disk 16 is recessed downward to form a placement area. The placement area is in an annular shape and is provided with a plurality of puncture holes at the bottom. The placement area is slidably connected with the sampling tube.

[0029] First, manually sample outside the detection box 1. The collected samples are packaged and stored through a sampling tube that drives the rubber seal. When it is necessary to detect the nucleic acid in the sampling tube, manually take a batch of sampling tubes again and place them upside down manually above the mixing plate 16. During the process when the rubber seal contacts the top of the mixing plate 16, the first spring 17 is stretched and the middle block 18 descends. During the process of the first spring 17 doing work downward, the bottom of the sampling tube touches the gasket 14, so that each sampling tube can be stable between the gasket 14 and the mixing plate 16. Drive the piston rod of the second cylinder 12 to rise. When the second cylinder 12 rises, drive the connecting cylinder 1201 to rise, so that each sampling needle 23 is aligned with the puncture hole at the bottom of the mixing plate 16. During this process, the sampling needle 23 touches the rubber seal and gives a downward pressure to the magnetic chuck 19, so that the groove in the inner circle of the magnetic chuck 19 is separated from the insert piece of the connecting cylinder 1201, and the magnetic chuck 19 can also rotate. During the rising process of the second cylinder 12, the sampling needle 23 pierces the rubber seal of the sampling tube, and then the head of the sampling needle 23 enters the sampling tube. Then drive the motor 3 to rotate at a low speed. When the motor 3 rotates, the belt 4 rotates. During the rotation of the belt 4, the rotating rod 15 rotates. The rotation of the rotating rod 15 drives the driving gear to rotate. The driving gear is in mesh with each first gear 8. During its rotation, the first gear 8 can drive each transmission rod 13 to rotate, so that the gasket 14 drives the sampling tube to rotate. The rubber seal of the sampling tube slides and contacts the top of the mixing plate 16. Therefore, during the rotation of the motor 3, the liquid to be detected inside the sampling tube is centrifugally mixed, which improves the concentration of the liquid to be detected. During the mixing process of the sampling tube, the liquid to be detected inside the sampling tube floods into the sampling needle 23, and the liquid to be detected inside the sampling tube is drained into the discharge cavity 2201 inside the sampling needle 23 and the magnetic head seat 22 for storage.Among them, the material control ball 24 in the material discharge chamber 2201 is located at the bottom of the material discharge chamber 2201 due to the action of gravity, so that the bottom of the material discharge chamber 2201 is in a blocked state. Then, after each magnetic head seat 22 takes a sample, the second cylinder 12 can be driven to descend and reset again, so that the sampling needle 23 and the sampling tube are separated. The rubber seal of the sampling tube has elasticity to seal the bottom of the sampling tube to prevent the liquid to be detected inside the sampling tube from flowing out. Immediately afterwards, the second gear 11 is driven to rotate again (a second motor can be installed on the top of one of the second gears 11, not shown). When one of the second gears 11 rotates, the chain belt 9 can be driven to rotate. When the chain belt 9 rotates, the magnetic attraction seat 30 can contact the side wall of the magnetic head seat 22, and at the same time, the chip 31 is located in front of the magnetic attraction seat 30, and each magnetic head seat 22 on the magnetic suction cup 19 is shoveled onto each magnetic attraction seat 30. There is a gap in the middle of the two chips 31 during this process, which can be used to place the material control ball 24, so that no overflow phenomenon occurs inside the sampling needle 23 and the magnetic head seat 22 during the process of transferring the magnetic head seat 22 to the magnetic attraction seat 30. Since the internal volumes of the sampling needles 23 connected to each material discharge chamber 2201 and the magnetic head seat 22 are equal, quantitative sampling can be performed;

[0030] One side of the top of the placement table 6 is fixedly connected with a base 10. The middle of the base 10 is fixedly connected with a second cylinder 12. The top of the second cylinder 12 is provided with a quantitative sampling device for extracting the liquid to be detected inside the sampling tube; the quantitative sampling device includes a connecting cylinder 1201 fixed to the top of the second cylinder 12. The top of the connecting cylinder 1201 is provided with a magnetic suction cup 19. A plurality of magnetic head seats 22 are magnetically connected to the top of the magnetic suction cup 19. The bottom of each magnetic head seat 22 is fixedly connected with a sampling needle 23, and each sampling needle 23 corresponds to the bottom of the puncture hole; the quantitative sampling device further includes an insertion piece arranged at the top of the outer circle of the connecting cylinder 1201. A groove corresponding to the insertion piece is opened in the inner circle of the magnetic suction cup 19. A second spring 20 is fixedly connected inside the connecting cylinder 1201. The top of the second spring 20 is fixedly connected with a lifting plate 21. The lifting plate 21 extends towards the bottom of the magnetic suction cup 19 and contacts the bottom of the magnetic suction cup 19; a material discharge chamber 2201 is opened inside each magnetic head seat 22. A material control ball 24 is movably connected inside the material discharge chamber 2201. When the chip 31 contacts the bottom of the magnetic head seat 22, the magnetic head seat 22 and the magnetic attraction seat 30 are attracted together by magnetism. When the top position piece 29 contacts the material control ball 24, the material control ball 24 is movable inside the material discharge chamber 2201; the material control ball 24 is made of metal and its surface is polished; each material discharge chamber 2201 is communicated with the sampling needle 23, and it has a shape with the upper part wide and the lower part narrow formed by the inner top side wall extending downwards. The bottom of the material discharge chamber 2201 fits with the material control ball 24. One end of the docking platform 7 is detachably connected with a collection bin 25, and the top of the collection bin 25 is communicated with the bottom of the spray pressure chamber 26.

[0031] When one of the magnetic adsorption seats 30 is displaced above the top position piece 29, the chip 31 crosses the side wall of the top position piece 29, and the material control ball 24 contacts the top position piece 29, causing the material control ball 24 to roll above the top position piece 29. At the same time, the top position piece 29 pushes the material control ball 24 upward, opening the discharge cavity 2201 inside the magnetic head seat 22, so that the liquid to be detected drips from the inside of the discharge cavity 2201 along the top position piece 29 into the inside of the reagent kit 27. After the reaction between the developing area inside the reagent kit 27 and the liquid to be detected, the first cylinder 5 is then driven to descend. After the first cylinder 5 descends, the detector 501 is brought close to the upper part of the reagent kit 27 to analyze and detect the nucleic acid. After recording the current data, the top position piece 29 and the reagent kit 27 are taken out manually for replacement. After the chain belt 9 drives the sampling needle 23 and the magnetic head seat 22 to be located inside the spraying and pressing chamber 26, the top position piece 29 is also included inside the spraying and pressing chamber 26. The disinfectant can be repeatedly filled inside the drainage machine 2. Then, the pump on the drainage machine 2 is turned on to spray the disinfectant onto the outside and inside of the sampling needle 23 and the magnetic head seat 22. When the material control ball 24 contacts the top position piece 29 again, the disinfectant enters the sampling needle 23 and the discharge cavity 2201 to thoroughly disinfect them. The disinfected water flows into the collection bin 25 and can be poured out manually after it is full. The reagent kit 27 and the top position piece 29 are detachable and are disposable items. During the detection process of the device, the sampling needle 23 and the magnetic head seat 22 are disinfected simultaneously, and the two operations are synchronous, which improves the number of samples detected by the device in a short time and also reduces the detection time of the samples. After each sampling needle 23 and magnetic head seat 22 are disinfected, all the sampling tubes above the mixing disc 16 are taken and replaced manually, and the magnetic head seat 22 is placed back on the magnetic suction disc 19, making the operation of the device simple.

[0032] It should be noted that in this text, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or sequence between these entities or operations. Moreover, the term "comprising", "including" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device comprising a series of elements not only includes those elements but also includes other elements not explicitly listed, or further includes elements inherent to such process, method, article or device.

[0033] Although the embodiments of the present invention have been shown and described, those of ordinary skill in the art can understand that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A nucleic acid detection and analysis device with a mixing structure, comprising a detection box (1), characterized in that: A placement table (6) is fixedly installed at the inner bottom of the detection box (1). Drive rods are rotatably connected to the four sides of the placement table (6). A pair of second gears (11) are fixed on each drive rod. A chain belt (9) is sleeved on the multiple second gears (11). A plurality of magnetic suction seats (30) are fixedly installed on the inner ring of the chain belt (9). A pair of slicing pieces (31) are fixedly connected to one side of each magnetic suction seat (30). A docking table (7) is fixedly installed on the top of the placement table (6). Insertion rods (28) are detachably connected to both sides of the top of the docking table (7). A top positioning piece (29) is fixedly connected to the top of each insertion rod (28). A drainage machine (2) is fixedly connected to the middle of one side of the detection box (1). A spraying and pressing chamber (26) is fixedly arranged on one side inside the detection box (1). The spraying and pressing chamber (26) is fixedly connected to the drainage machine (2). One of the top positioning pieces (29) is located inside the spraying and pressing chamber (26). A reagent kit (27) is detachably connected to one side of the docking table (7). A first air cylinder (5) is suspended at the inner top of the detection box (1). An inspection instrument (501) is fixedly connected to the bottom of the first air cylinder (5); A mixing structure for mixing the sampling tube is fixedly connected to one side of the placement table (6). After the mixing structure contacts the slicing piece (31), the liquid to be detected is transferred into the reagent kit (27) for detection by moving through the chain belt (9); A base (10) is fixedly connected to one side of the top of the placement table (6). A second air cylinder (12) is fixedly connected to the middle of the base (10). A quantitative sampling device for extracting the liquid to be detected inside the sampling tube is installed on the top of the second air cylinder (12); The quantitative sampling device includes a connecting cylinder (1201) fixed to the top of the second air cylinder (12). A magnetic suction disc (19) is installed on the top of the connecting cylinder (1201). A plurality of magnetic head seats (22) are magnetically connected to the top of the magnetic suction disc (19). A sampling needle (23) is fixedly connected to the top of each magnetic head seat (22); A discharge cavity (2201) is formed inside each magnetic head seat (22). A control material ball (24) is movably connected inside the discharge cavity (2201). When the slicing piece (31) contacts the bottom of the magnetic head seat (22), the magnetic head seat (22) and the magnetic suction seat (30) are attracted together by magnetism. When the top positioning piece (29) contacts the control material ball (24), the control material ball (24) moves inside the discharge cavity (2201); Each discharge cavity (2201) communicates with the sampling needle (23), and it has a shape with the side wall of the inner top extending downward to form a wider upper part and a narrower lower part. The bottom of the discharge cavity (2201) fits with the control material ball (24).

2. The nucleic acid detection and analysis device with a mixing structure according to claim 1, wherein: The mixing structure includes a plurality of driving rods (13) rotatably connected to the inner top of the detection box (1). A gasket (14) is fixedly connected to the bottom of each driving rod (13). A first gear (8) is fixedly connected to the top of each driving rod (13). A motor (3) is fixedly connected to the top of the detection box (1). A belt (4) is sleeved on the output shaft of the motor (3). One end of the belt (4) is sleeved on a rotating rod (15). One end of the rotating rod (15) extends into the detection box (1) through the detection box (1). A middle block (18) is slidably connected to the bottom of the rotating rod (15). A mixing disk (16) is slidably connected to the outside of the middle block (18). The sampling tube includes a rubber seal. When the sampling tube is buckled, the rubber seal contacts the top of the mixing disk (16), the first spring (17) is stretched, the middle block (18) descends, and the bottom of the sampling tube contacts the gasket (14), so that the sampling tube is stable between the gasket (14) and the mixing disk (16). A first spring (17) is fixedly connected to the inner bottom of the rotating rod (15). The first spring (17) is fixedly connected to the middle block (18). A driving gear is fixedly installed at the top of the rotating rod (15). The driving gear meshes with each first gear (8).

3. The nucleic acid detection and analysis device with a mixing structure according to claim 2, characterized in that: A placement area is formed by the middle part of the mixing disk (16) being recessed downward. The placement area is in an annular shape and is provided with a plurality of puncture holes at the bottom. The placement area is slidably connected to the sampling tube.

4. The nucleic acid detection and analysis device with a mixing structure according to claim 3, characterized in that: The bottom of each sampling needle (23) corresponds to the bottom of the puncture hole.

5. The nucleic acid detection and analysis device with a mixing structure according to claim 4, wherein: The quantitative sampling device further includes inserts provided at the top of the outer circle of the connecting cylinder (1201). A groove corresponding to the inserts is formed in the inner circle of the magnetic suction cup (19). A second spring (20) is fixedly connected to the inside of the connecting cylinder (1201). The top of the second spring (20) is fixedly connected to a lifting plate (21). The lifting plate (21) extends towards the bottom of the magnetic suction cup (19) and contacts the bottom of the magnetic suction cup (19).

6. The nucleic acid detection and analysis device with a mixing structure according to claim 5, characterized in that: The material control ball (24) is made of metal and its surface is polished.

7. The nucleic acid detection and analysis device with a mixing structure according to claim 1, wherein: One end of the docking platform (7) is detachably connected to a collection bin (25). The top of the collection bin (25) communicates with the bottom of the spraying and pressing chamber (26).

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